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Metabolic syndrome children

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https://www.readbyqxmd.com/read/29326970/revisiting-sweat-chloride-test-results-based-on-recent-guidelines-for-diagnosis-of-cystic-fibrosis
#1
Jayson V Pagaduan, Mahesheema Ali, Michael Dowlin, Liye Suo, Tabitha Ward, Fadel Ruiz, Sridevi Devaraj
Objectives: Recent sweat chloride guidelines published by the Cystic Fibrosis Foundation changed the intermediate sweat chloride concentration range from 40-59 mmol/L to 30-59 mmol/L for age > 6 months. We wanted to know how this new guideline would impact detection of cystic fibrosis among patients who previously had sweat tests done at Texas Children's Hospital. Methods: We revisited sweat chloride test results (n = 3012) in the last 5 years at Texas Children's Hospital based on the new guidelines on diagnosis of cystic fibrosis from the Cystic Fibrosis Foundation...
March 2018: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/29322175/association-of-psoriasis-with-comorbidity-development-in-children-with-psoriasis
#2
Megha M Tollefson, Holly K Van Houten, Dennis Asante, Xiaoxi Yao, Hilal Maradit Kremers
Importance: Children with psoriasis are at increased risk for comorbidities. Many children with psoriasis are also overweight or obese; it is unknown whether the increased risk of comorbidities in these children is independent of obesity. Objective: To determine the risk of elevated lipid levels (hyperlipidemia/hypertriglyceridemia), hypertension, metabolic syndrome, polycystic ovarian syndrome, diabetes, nonalcoholic liver disease, and elevated liver enzyme levels in children with and without psoriasis, after accounting for obesity...
January 10, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29320957/cardiovascular-and-metabolic-health-of-74-children-from-women-previously-diagnosed-with-polycystic-ovary-syndrome-in-comparison-with-a-population-based-reference-cohort
#3
Marlieke A de Wilde, Jacobien B Eising, Marlise N Gunning, Maria P H Koster, Annemieke M V Evelein, Geertje W Dalmeijer, Cuno S P M Uiterwaal, Marinus J C Eijkemans, Cornelis K van der Ent, Folkert J Meijboom, Bart C J M Fauser
Women with polycystic ovary syndrome (PCOS) have compromised cardiovascular health profiles and an increased risk of pregnancy complications. In order to evaluate potential consequences, we aim to compare the cardiovascular and metabolic health of the children from women with PCOS with a population-based reference cohort. We included children from women with PCOS between the age of 2.5 to 4 years (n = 42) and 6 to 8 years (n = 32). The reference groups consisted of 168 (3-4 years old) and 130 children (7-8 years old)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29319392/the-association-between-serum-vaspin-and-omentin-1-levels-in-obese-children-with-metabolic-syndrome
#4
Muammer Buyukinan, Muge Atar, Ummugulsum Can, Ozgur Pirgon, Asuman Guzelant, Isa Deniz
BACKGROUND AND AIM: Excess visceral fat accumulation results in altered release of adipokines. The aim of this study was to examine the relationship between new adipokines (omentin-1 and vaspin), insulin resistance, and serum inflammatory markers in obese subjects with metabolic syndrome (MS). PATIENTS AND METHODS: The study included a total of 121 obese children (79 females and 42 males, aged 12-17 years old). The obese subjects were divided into two groups based on the presence or absence of MS criteria (MS group and non-MS group)...
January 10, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29317557/prevalence-of-nonalcoholic-fatty-liver-disease-in-normal-weight-and-overweight-preadolescent-children-in-haryana-india
#5
Manoja Kumar Das, Vidyut Bhatia, Anupam Sibal, Abha Gupta, Sarath Gopalan, Raman Sardana, Reeti Sahni, Ankur Roy, Narendra K Arora
OBJECTIVE: To document the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic parameters among normal-weight and overweight schoolchildren. STUDY DESIGN: Cross-sectional study. SETTING: Thirteen private schools in urban Faridabad, Haryana. PARTICIPANTS: 961 school children aged 5-10 years. METHODS: Ultrasound testing was done, and 215 with fatty liver on ultrasound underwent further clinical, biochemical and virological testing...
December 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29305232/comparison-of-different-maximal-oxygen-uptake-equations-to-discriminate-the-cardiometabolic-risk-in-children-and-adolescents
#6
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Jorge Mota, Antonio Garcia-Hermoso
OBJECTIVE: To determine the ability of 8 different maximal oxygen uptake (VO2max) equations to discriminate between low and high cardiometabolic risk, and to determine cardiorespiratory fitness (CRF) cutoffs associated with a more favorable cardiometabolic risk profile in Colombian children and adolescents. STUDY DESIGN: In a cross-sectional study, CRF was estimated using the 20-m shuttle run test in 2870 schoolchildren (54.5% girls) from Bogota, Colombia. We computed a metabolic syndrome score (MetScore) as the sum of the age- and sex-standardized scores of waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood pressure...
January 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29298340/the-association-between-a-body-shape-index-and-cardiovascular-risk-in-overweight-and-obese-children-and-adolescents
#7
Chiara Mameli, Nir Y Krakauer, Jesse C Krakauer, Alessandra Bosetti, Chiara Matilde Ferrari, Norma Moiana, Laura Schneider, Barbara Borsani, Teresa Genoni, Gianvincenzo Zuccotti
A Body Shape Index (ABSI) and normalized hip circumference (Hip Index, HI) have been recently shown to be strong risk factors for mortality and for cardiovascular disease in adults. We conducted an observational cross-sectional study to evaluate the relationship between ABSI, HI and cardiometabolic risk factors and obesity-related comorbidities in overweight and obese children and adolescents aged 2-18 years. We performed multivariate linear and logistic regression analyses with BMI, ABSI, and HI age and sex normalized z scores as predictors to examine the association with cardiometabolic risk markers (systolic and diastolic blood pressure, fasting glucose and insulin, total cholesterol and its components, transaminases, fat mass % detected by bioelectrical impedance analysis) and obesity-related conditions (including hepatic steatosis and metabolic syndrome)...
2018: PloS One
https://www.readbyqxmd.com/read/29290474/triglycerides-high-density-lipoprotein-cholesterol-ratio-as-a-cardiometabolic-risk-marker-in-children-and-adolescents-from-m%C3%A3-rida-city-venezuela
#8
Miguel Aguirre, Yajaira Briceño, Roald Gómez-Pérez, Yajaira Zerpa, Nolis Camacho, Mariela Paoli
OBJECTIVE: To determine the behavior of the triglycerides/HDL-cholesterol ratio (TG/HDL) as a cardiometabolic risk marker in children and adolescents from Mérida, Venezuela. METHODS: A total of 1292 children and adolescents aged 7-18 years who attended educational institutions in the Libertador Municipality were enrolled into this study. Anthropometric measurements and blood pressure values were recorded. Fasting blood glucose, insulin and lipid levels were measured...
December 28, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29290033/effects-of-obesity-and-metabolic-syndrome-on-cardiovascular-outcomes-in-pediatric-kidney-transplant-recipients-a-longitudinal-study
#9
Kristen Sgambat, Sarah Clauss, K Y Lei, Juizhou Song, Shaik O Rahaman, Margaret Lasota, Asha Moudgil
BACKGROUND: Obesity and metabolic syndrome (MS) are common after kidney transplantation, but their contribution to adverse cardiovascular (CV) outcomes in children are not well known. A prospective, controlled, longitudinal cohort study was conducted to investigate the effects of obesity and MS on left ventricular hypertrophy (LVH) and myocardial strain in pediatric kidney transplant recipients. METHODS: Transplant recipients (n = 42) had anthropometrics [body mass index (BMI), waist circumference, waist-to-height ratio], biochemical parameters (fasting glucose, lipid panel, HbA1c%), and echocardiogram with speckle tracking analysis for strain measured at 1, 18, and 30 months post-transplant...
December 30, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29287595/dealing-with-chronic-non-bacterial-osteomyelitis-a-practical-approach
#10
REVIEW
Andrea Taddio, Giovanna Ferrara, Antonella Insalaco, Manuela Pardeo, Massimo Gregori, Martina Finetti, Serena Pastore, Alberto Tommasini, Alessandro Ventura, Marco Gattorno
BACKGROUND: Chronic Non-Bacterial Osteomyelitis (CNO) is an inflammatory disorder that primarily affects children. Although underestimated, its incidence is rare. For these reasons, no diagnostic and no therapeutic guidelines exist. The manuscript wants to give some suggestions on how to deal with these patients in the every-day clinical practice. MAIN BODY: CNO is characterized by insidious onset of bone pain with local swelling. Systemic symptoms such as fever, skin involvement and arthritis may be sometimes present...
December 29, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29280741/insulin-resistance-prediabetes-metabolic-syndrome-what-should-every-pediatrician-know
#11
Ahmad Ighbariya, Ram Weiss
The Metabolic syndrome describes a clustering of typical cardiovascular risk factors. The syndrome is also known as "Insulin Resistance syndrome" as a substantial part of the pathophysiology is driven by resistance to the metabolic effects of insulin. The major cause of insulin resistance in childhood is a typical lipid partitioning pattern characterized by increased deposition of lipids within insulin responsive tissues, such as the liver and skeletal muscle and within the viscera. This lipid deposition pattern is also associated with infiltration of intra-abdominal tissues with cells of the immune system, inducing systemic, low-grade inflammation typically observed in insulin resistant obese children and adolescents...
December 27, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29278628/perinatal-complications-in-two-cohort-groups-of-preterm-newborns-in-intensive-care-unit-for-children-s-diseases-of-university-clinical-hospital-mostar
#12
Vedran Bjelanović, Marjana Jerković Raguž, Matea Galić, Ana Čuljak, Ivana Bjelanović, Vajdana Tomić
AIM: To determine the frequency and type of complications in two cohort groups of preterm newborns. SUBJECTS AND METHODS: The research involved 100 preterm newborns divided into two groups according to their gestational age: newborns from 24 to 33+6/7 weeks GA and newborns from 34 to 36+6/7 weeks GA. Parameters which were observed with mother were: age, number of births, course and complications in pregnancy. Parameters with infant: gestational age, weight, newborn small for gestational age (IUGR), asphyxia, respiratory distress syndrome, sepsis, hyperbilirubinemia, apnea, anemia, intracranial hemorrhage and metabolic disorder (hypoglycaemia, hypocalcaemia)...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29276231/preconception-optimization-of-glucose-and-insulin-metabolism-in-women-wanting-to-conceive-high-rate-of-spontaneous-conception-prior-to-planned-assisted-reproduction
#13
Sara Fill Malfertheiner, Dagmar Gutknecht, Monika Bals-Pratsch
Background: A hyperglycemic metabolic status with insulin resistance can have a negative effect on fertility and pregnancy outcomes. The aim of this retrospective study was to investigate disorders of glucose and insulin metabolism in women wanting to conceive who conceived spontaneously prior to planned assisted reproduction (ART). Associated risk factors of patients in terms of live births and miscarriages were also analyzed. Method: Out of total study population of 589 pregnancies, the pregnancies of 129 women wishing to have children who conceived spontaneously prior to planned ART were analyzed in more detail...
December 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29274110/metabolic-correlates-of-cognitive-function-in-children-with-unilateral-sturge-weber-syndrome-evidence-for-regional-functional-reorganization-and-crowding
#14
Jeong-A Kim, Jeong-Won Jeong, Michael E Behen, Vinod K Pilli, Aimee Luat, Harry T Chugani, Csaba Juhász
To evaluate metabolic changes in the ipsi- and contralateral hemisphere in children showing a cognitive profile consistent with early reorganization of cognitive function, we evaluated the regional glucose uptake, interhemispheric metabolic connectivity, and cognitive function in children with unilateral SWS. Interictal 2-deoxy-2[18 F]fluoro-D-glucose (FDG)-PET scans of 27 children with unilateral SWS and mild epilepsy and 27 age-matched control (non-SWS children with epilepsy and normal FDG-PET) were compared using statistical parametric mapping (SPM)...
December 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29273941/associations-between-metabolic-syndrome-components-and-markers-of-inflammation-in-welsh-school-children
#15
Non Eleri Thomas, David A Rowe, Elaine M Murtagh, Jeffrey W Stephens, Rhys Williams
We investigated the multivariate dimensionality and strength of the relationship between metabolic syndrome (MetS) and inflammation in children. Caucasian school children (N = 229; 12-14 years) from Wales were tested on several health indicators including measures of body composition, inflammation, fasting glucose regulation, blood pressure, and lipids. The multivariate association between MetS and inflammation was investigated via canonical correlation analysis. Data were corrected for non-normality by log transformation, and sex-specific z-scores computed for variables where there was a significant sex difference...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29249003/mitochondrial-disease-in-children-the%C3%A2-nephrologist-s-perspective
#16
Paula Pérez-Albert, Carmen de Lucas Collantes, Miguel Ángel Fernández-García, Teresa de Rojas, Cristina Aparicio López, Luis Gutiérrez-Solana
Mitochondrial diseases (MD) are a heterogeneous group of clinical syndromes characterized by the involvement of different organ systems. They constitute the most prevalent hereditary metabolic disease group. OBJECTIVE: To review the importance of the kidney in MD from the nephrologist's perspective within the setting of a pediatric tertiary reference center. STUDY DESIGN: Retrospective study of children (<18 years) with MD followed between 2000 and 2016 at a tertiary Spanish center...
December 17, 2017: JIMD Reports
https://www.readbyqxmd.com/read/29247988/interleukin-18-biological-properties-and-role-in-disease-pathogenesis
#17
REVIEW
Gilles Kaplanski
Initially described as an interferon (IFN)γ-inducing factor, interleukin (IL)-18 is indeed involved in Th1 and NK cell activation, but also in Th2, IL-17-producing γδ T cells and macrophage activation. IL-18, a member of the IL-1 family, is similar to IL-1β for being processed by caspase 1 to an 18 kDa-biologically active mature form. IL-18 binds to its specific receptor (IL-18Rα, also known as IL-1R7) forming a low affinity ligand chain. This is followed by recruitment of the IL-18Rβ chain. IL-18 then uses the same signaling pathway as IL-1 to activate NF-kB and induce inflammatory mediators such as adhesion molecules, chemokines and Fas ligand...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29247169/cardiometabolic-risk-factors-in-childhood-adolescent-and-young-adult-survivors-of-acute-lymphoblastic-leukemia-a-petale-cohort
#18
Emile Levy, Mariia Samoilenko, Sophia Morel, Jade England, Devendra Amre, Laurence Bertout, Simon Drouin, Caroline Laverdière, Maja Krajinovic, Daniel Sinnett, Geneviève Lefebvre, Valérie Marcil
Our objectives were to assess the prevalence of cardiometabolic complications in children, adolescents, and young adult survivors of childhood acute lymphoblastic leukemia (cALL), to identify their predictors and the risk compared to the Canadian population. We performed a cardiometabolic assessment of cALL survivors from the PETALE cohort (n = 247, median age at visit of 21.7 years). In our group, overweight and obesity affected over 70% of women. Pre-hypertension and hypertension were mostly common in men, both adults (20%) and children (19%)...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29247150/adiposity-in-juvenile-psoriatic-arthritis
#19
Aaida Samad, Matthew L Stoll, Idit Lavi, Joyce J Hsu, Vibeke Strand, Thomas N Robinson, Elizabeth D Mellins, Devy Zisman
OBJECTIVE: Adult patients with psoriatic arthritis are at increased risk for obesity and metabolic syndrome, but data regarding adiposity in children with juvenile psoriatic arthritis (JPsA) are limited. Our study assessed adiposity in children with JPsA in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. METHODS: Patients with JPsA in the CARRA registry were divided into nonoverweight and overweight groups using recommendations from the US Centers for Disease Control, and differences in demographic and clinical characteristics between groups at baseline and after 1-year followup were assessed using chi-square test, Fisher's exact test, T test, or Mann-Whitney U test, as appropriate...
December 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29240010/well-preserved-renal-function-in-children-with-untreated-chronic-liver-disease
#20
Ulla B Berg, Antal Németh
OBJECTIVES: Based on studies with hepatorenal syndrome, it is widely regarded that renal function is impacted in chronic liver disease. Therefore we investigated renal function in our children with chronic liver disease. METHODS: In a retrospective study of 277 children with chronic liver disease, renal function was investigated as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), measured as clearance of inulin and para-amino hippuric acid or clearance of iohexol...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
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