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Metabolic syndrome children

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https://www.readbyqxmd.com/read/27921049/metabolic-syndrome-in-children-and-adolescents
#1
REVIEW
Christine Graf, Nina Ferrari
BACKGROUND: Juvenile obesity is associated with multiple cardiometabolic comorbidities, which may culminate in the metabolic syndrome (MetS). METHODS: Based on a narrative review, the current knowledge of prevalence and the underlying metabolic principles regarding juvenile obesity and MetS are summarized to compile up-to-date information. In addition, the role of lifestyle as well as positive and negative influencing factors are focused on. RESULTS: The prevalence of MetS occurs between 1 and up to 23% in the total pediatric population and in up to 60% amongst the obese and overweight...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27906623/orotate-orotic-acid-an-essential-and-versatile-molecule
#2
M Löffler, E A Carrey, E Zameitat
Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. OA is also a normal part of the diet, being found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes. Early research into nutrition identified orotate as "vitamin B13," and its use as a complex with organic cations or metal ions was promulgated in body-building, and in assisting therapies of metabolic syndromes...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27898589/growth-in-patients-with-type-1-diabetes
#3
Deborah M Mitchell
PURPOSE OF REVIEW: As the incidence of type 1 diabetes (T1DM) continues to rise, complications including impairment of childhood growth remain a major concern. This review provides an overview of alterations in growth patterns before and after the onset of T1DM. RECENT FINDINGS: Recent advances in this field include several prospective investigations of height and weight trajectories in children leading up to the development of islet autoimmunity and T1DM as well as evaluations of larger cohorts of T1DM patients to better assess predictors of altered growth...
November 24, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27891759/sociodemographic-correlates-and-family-aggregation-of-leukocyte-telomere-length-in-adults-and-children-from-mesoamerica
#4
Kerry S Flannagan, Erica C Jansen, Laura S Rozek, Katie M Rentschler, Ana Victoria Roman, Manuel Ramirez-Zea, Eduardo Villamor
OBJECTIVE: Telomere length is a biomarker of cumulative stress and inflammation related to chronic disease risk. We examined the associations of leukocyte telomere length (LTL) with sociodemographic and anthropometric variables and estimated LTL family aggregation in Central America, a region with a high burden of chronic disease where LTL has not been studied. METHODS: We conducted a cross-sectional study of 174 school age children and their parents in the capital cities of Belize, Honduras, Nicaragua, Costa Rica, Panama, and the city of Tuxtla-Gutierrez in Mexico...
November 28, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27889187/maternal-polycystic-ovary-syndrome-and-risk-for-attention-deficit-hyperactivity-disorder-in-the-offspring
#5
Kyriaki Kosidou, Christina Dalman, Linnea Widman, Stefan Arver, Brian K Lee, Cecilia Magnusson, Renee M Gardner
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood neurodevelopmental disorder, and boys are two to three times more likely to develop ADHD. Maternal polycystic ovary syndrome (PCOS), a common metabolic disorder associated with excess circulating androgens, has been associated with increased risk for autism spectrum disorder in the offspring. In this study, we aimed to investigate whether maternal PCOS increases the risk for ADHD in the offspring...
October 6, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27888639/association-between-body-mass-index-and-salivary-uric-acid-among-mexican-origin-infants-youth-and-adults-gender-and-developmental-differences
#6
Airín D Martínez, Lillian Ruelas, Douglas A Granger
Uric acid (UA) is the end product of the metabolic breakdown of purine nucleotides. Recent studies have measured UA in saliva in relation to obesity and chronic disease risk. Given the increasing prevalence of metabolic syndrome among Latino youth, we examined gender and age differences in salivary uric acid (sUA) and weight in a sample of Mexican-origin children (n = 65, 2 months to 18 years, 49% female) and adults (n = 46, 19-58 years, 72% female). We measured weight, height, waist, and hip circumference and collected saliva samples (later assayed for sUA)...
November 26, 2016: Developmental Psychobiology
https://www.readbyqxmd.com/read/27882292/muscular-strength-and-endurance-and-cardio-metabolic-health-in-disadvantaged-hispanic-children-from-the-u-s
#7
Ryan D Burns, Timothy A Brusseau
The predictive relationship between muscular strength and endurance and cardio-metabolic health, independent from aerobic fitness, is not clear in disadvantaged Hispanic children. The purpose of this study was to examine the predictive relationship between muscular strength and endurance and clustered cardio-metabolic risk, controlling for aerobic fitness, in Hispanic children from low-income schools. Participants were 320 Hispanic children (Mean age = 10.1 ± 1.1 years; 164 girls, 156 boys) recruited during the 2014-2015 and 2015-2016 academic years from five low-income schools from the state of Utah in the U...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27878212/obesity-paradox-obesity-orthodox-and-the-metabolic-syndrome-an-approach-to-unity
#8
Jesse Roth, Navneet Sahota, Priya Patel, Syed Faizan Mehdi, Mohammad Masum Wiese, Hafiz B Mahboob, Michelle Bravo, Daniel J Eden, Muhammad A Bashir, Amrat Kumar, Farah Alsaati, Irwin J Kurland, Wunnie Brima, Ann Danoff, Alessandra L Szulc, Valentin A Pavlov, Kevin J Tracey, Huan Yang
Obesity and the accompanying metabolic syndrome are strongly associated with heightened morbidity and mortality in older adults. In our review of more than 20 epidemiologic studies of major infectious diseases, including leaders such as tuberculosis, community-acquired pneumonia, and sepsis, obesity was associated with better outcomes. A cause-and-effect relationship between over-nutrition and survival with infection is suggested by results of two preliminary studies of infections in mice, where high fat feeding for 8-10 weeks provided much better outcomes...
November 16, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27875502/sniffing-out-paediatric-gastrointestinal-diseases-the-potential-of-volatile-organic-compounds-as-biomarkers-for-disease
#9
Martin Buijck, Daniel J C Berkhout, Evelien F J de Groot, Marc A Benninga, Marc P C van der Schee, Corneille Marie Frank Kneepkens, Nanne K H de Boer, Tim G J de Meij
The diagnostic work-up and follow-up of paediatric functional gastrointestinal disorders and organic conditions usually includes invasive tests, carrying a high burden on patients. There is a place, therefore, for novel, noninvasive disease-specific biomarkers. Volatile organic compounds (VOCs), originating from (patho)physiological metabolic processes in the human body, are excreted as waste products through all conceivable bodily excrements. The spectrum of VOCs harbours a magnificent source of information, with the potential to serve as noninvasive diagnostic biomarkers and to monitor disease activity...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27875418/nonclassic-features-of-pseudohypoparathyroidism-type-1a
#10
Ashley H Shoemaker, Harald Jüppner
PURPOSE OF REVIEW: To provide readers with a review of contemporary literature describing the evolving understanding of the pseudohypoparathyroidism type 1A (PHP1A) phenotype. RECENT FINDINGS: The classic features of PHP1A include multihormone resistance and the Albright Hereditary Osteodystrophy phenotype (round facies, short stature, subcutaneous ossifications, brachydactyly, and early-onset obesity. Obesity may be because of a decrease in resting energy expenditure because most patients do not report significant hyperphagia...
November 21, 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27871765/-evaluation-of-cardiac-function-in-a-group-of-small-for-gestational-age-school-age-children-treated-with-growth-hormone
#11
Esther Aurensanz Clemente, Ariadna Ayerza Casas, Pilar Samper Villagrasa, Pablo Ruiz Frontera, Gloria Bueno Lozano
INTRODUCTION AND OBJECTIVES: Small for gestational age (SGA) patients have an increased risk of developing a cardiovascular pathology, as well as a metabolic syndrome. Our objective is to evaluate the cardiac morphology and function of SGA children treated with growth hormone (GH), identifying changes that could potentially have long-term consequences. METHODS: We selected 23 SGA school-age patients and 23 healthy children. We measured their weight, height, blood pressure and heart rate...
November 18, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27857783/hyponatremia-in-children-with-tuberculous-meningitis-a-hospital-based-cohort-study
#12
Prithi Inamdar, Sanjeevani Masavkar, Preeti Shanbag
BACKGROUND: Hyponatremia has long been recognized as a potentially serious metabolic consequence of tuberculous meningitis (TBM) occurring in 35-65% of children with the disease. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has for long been believed to be responsible for the majority of cases of hyponatremia in TBM. Cerebral salt wasting syndrome (CSWS) is being increasingly reported as a cause of hyponatremia in some of these children. AIM: This study was done to determine the frequency and causes of hyponatremia in children with TBM...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27834078/epidemiology-of-childhood-obesity-in-korea
#13
REVIEW
Kyoung Hwa Ha, Dae Jung Kim
Over the past several decades, the prevalence of obesity has increased dramatically worldwide and is increasing not only in developed countries, but also in developing countries. This increase may lead to an increase in the incidence of chronic diseases throughout the lifespan. In Korean children and adolescents, the prevalence of obesity increased from 6.8% in 1998 to 10.0% in 2013. Obesity is a state that more commonly influences children and adolescents of lower socioeconomic status (SES) than those with a higher SES...
November 3, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27832551/anaesthetic-implications-of-the-changing-management-of-patients-with-mucopolysaccharidosis
#14
H A Hack, Rwm Walker, P Gardiner
The mucopolysaccharidoses are a group of inherited metabolic disorders that are renowned for presenting clinical problems, particularly related to cardiac, airway, and skeletal abnormalities, in children during anaesthesia. The changing clinical management of the mucopolysaccharidoses can be described in three phases. An initial phase of accumulation and dissemination of knowledge about the management of this rare disease with a growing recognition that untreated Hurler syndrome and more severe forms of other phenotypes such as Hunter syndrome and Maroteaux-Lamy syndrome were associated with severe complications under anaesthesia...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27832021/adiponectin-leptin-and-inflammatory-markers-in-hiv-associated-metabolic-syndrome-in-children-and-adolescents
#15
María Espiau, Diego Yeste, Antoni Noguera-Julian, Pere Soler-Palacín, Clàudi Fortunyc, Roser Ferrer, Immaculada Comas, Andrea Martín-Nalda, Ángela Deyà-Martínez, Concepció Figueras, Antonio Carrascosa
BACKGROUND: Metabolic syndrome (MetS) is more common in HIV-infected adults and children than in the general population. Adipocytokines and inflammatory markers may contribute to the pathophysiology of this condition and could be useful indices for monitoring MetS. The objective of this study was to provide information on the prevalence of MetS and investigate the role of adipocytokines and other biomarkers in this syndrome in HIV-infected pediatric patients. METHODS: A cross-sectional study was conducted between October 2013 and March 2014 in the outpatient clinics of two tertiary pediatric referral hospitals...
November 8, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27824688/gross-motor-skills-and-cardiometabolic-risk-in-children-a-mediation-analysis
#16
Ryan D Burns, Timothy A Brusseau, You Fu, James C Hannon
PURPOSE: The purpose of this study was to examine the linear relationship between gross motor skills and cardiometabolic risk, with aerobic fitness as a mediator variable, in low-income children from the U.S. METHODS: Participants were a convenience sample of 224 children (Mean age = 9.1 ± 1.1 years; 129 girls, 95 boys) recruited from five low-income elementary schools from the Mountain West Region of the U.S. Gross motor skills were assessed using the Test for Gross Motor Development 3rd Edition...
November 7, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27822476/pathogenesis-of-nonalcoholic-steatohepatitis-interactions-between-liver-parenchymal-and-nonparenchymal-cells
#17
REVIEW
Nancy Magee, An Zou, Yuxia Zhang
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in both adults and children. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and cirrhosis. NASH is a manifestation of the metabolic syndrome and hepatic disorders with the presence of steatosis, hepatocyte injury (ballooning), inflammation, and, in some patients, progressive fibrosis leading to cirrhosis...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27814422/development-of-bullous-pemphigoid-in-a-patient-with-psoriasis-and-metabolic-syndrome
#18
Anna Lesniewska, Agnieszka Kalińska-Bienias, Cezary Kowalewski, Robert Schwartz, Katarzyna Wozniak
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease that most commonly affects adults older than 60 years, whereas psoriasis vulgaris (PV) is a chronic immune-mediated disease that affects both children and adults. Bullous pemphigoid and PV may coexist with each other as well as with various other internal disorders, which may lead to early death. We report the case of a 35-year-old man with a 15-year history of PV and obesity who developed tense blisters with annular arrangement and normal-appearing perilesional skin localized mainly on the trunk, arms, and legs resembling linear IgA bullous dermatosis...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27801385/a-review-of-metabolic-syndrome-research-in-malaysia
#19
K G Lim, W K Cheah
Seventy-three articles related to metabolic syndrome were found in a search through databases dedicated to indexing all literature with original data involving the Malaysian population between years 2000 and 2015. Metabolic syndrome affects 25 to 40% of adult population of Malaysia with the risk increasing with age. Obese children are also at risk. Indian ethnicity has the highest rates, followed by Malay and chinese. It was found that socioeconomics determinants such as living in urban areas, unemployment, lower income, lower education level and shift workers had higher prevalence of metabolic syndrome...
June 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27798047/common-diseases-as-determinants-of-menopausal-age
#20
Jingmei Li, Mikael Eriksson, Kamila Czene, Per Hall, Kenny A Rodriguez-Wallberg
STUDY QUESTION: Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER: Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY: It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively...
October 18, 2016: Human Reproduction
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