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Metabolic syndrome children

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https://www.readbyqxmd.com/read/28935462/insulin-resistance-serum-uric-acid-and-metabolic-syndrome-are-linked-to-cardiovascular-dysfunction-in-pediatric-obesity
#1
Giulia Genoni, Veronica Menegon, Gioel Gabrio Secco, Michela Sonzini, Massimiliano Martelli, Matteo Castagno, Roberta Ricotti, Alice Monzani, Michele Aronici, Elena Grossini, Carlo Di Mario, Gianni Bona, Simonetta Bellone, Flavia Prodam
INTRODUCTION: Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations. AIM: Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS)...
September 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28935142/association-between-neck-and-wrist-circumferences-and-cardiometabolic-risk-in-children-and-adolescents-the-caspian-v-study
#2
Roya Kelishadi, Motahar Heidari-Beni, Mostafa Qorbani, Nazgol Motamed-Gorji, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Tahereh Aminaee, Ramin Heshmat
OBJECTIVE: The predictive potentials of neck and wrist circumferences for cardiometabolic risks in children and adolescents remain to be determined. The aim of this study was to evaluate the association of neck and wrist circumferences with some cardiometabolic risk factors in children and adolescents. METHODS: This multicenter study was conducted during the 2014 to 2015 school year with 4200 children and adolescents ages 7 to 18 y. The children were selected by multistage cluster sampling from 30 provinces of Iran...
November 2017: Nutrition
https://www.readbyqxmd.com/read/28925408/liver-volume-and-hepatic-adiposity-in-childhood-relations-to-body-growth-and-visceral-fat
#3
R Malpique, J Bassols, A López-Bermejo, M Diaz, F Villarroya, J Pavia, A Congo, F de Zegher, L Ibáñez
BACKGROUND AND OBJECTIVE: The sequence of prenatal growth restraint and postnatal catch-up growth may lead to hepato-visceral adiposity, insulin resistance and low-grade inflammation before the onset of puberty. In prepubertal children born appropriate for gestational age (AGA) or small for gestational age (SGA), we assessed potential relationships between the aforementioned sequence and liver volume. SUBJECTS/METHODS: The study population consisted of 86 children (41 AGA and 45 SGA with catch-up growth; age (mean±s...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28916403/a-case-of-severe-acquired-hypertriglyceridemia-in-a-7-year-old-girl
#4
Jessica S Lilley, MacRae F Linton, Jennifer C Kelley, T Brent Graham, Sergio Fazio, Hagai Tavori
We report a case of severe type I hyperlipoproteinemia caused by autoimmunity against lipoprotein lipase (LPL) in the context of presymptomatic Sjögren's syndrome. A 7-year-old mixed race (Caucasian/African American) girl was admitted to the intensive care unit at Vanderbilt Children's Hospital with acute pancreatitis and shock. She was previously healthy aside from asthma and history of Hashimoto's thyroiditis. Admission triglycerides (TGs) were 2191 mg/dL but returned to normal during the hospital stay and in the absence of food intake...
August 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#5
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28914984/hypercalcemic-disorders-in-children
#6
REVIEW
Victoria J Stokes, Morten F Nielsen, Fadil M Hannan, Rajesh V Thakker
Hypercalcemia is defined as a serum calcium concentration that is greater than 2 standard deviations above the normal mean, which in children may vary with age and sex, reflecting changes in the normal physiology at each developmental stage. Hypercalcemic disorders in children may present with hypotonia, poor feeding, vomiting, constipation, abdominal pain, lethargy, polyuria, dehydration, failure to thrive and seizures. In severe cases renal failure, pancreatitis and reduced consciousness may also occur and older children and adolescents may present with psychiatric symptoms...
September 15, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28912339/reproductive-and-metabolic-features-during-puberty-in-sons-of-women-with-polycystic-ovary-syndrome
#7
Nicolas Crisosto, Barbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren, Teresa Sir-Petermann
CONTEXT: Intrauterine life may be implicated in the origin of polycystic cvary syndrome (PCOS) modifying the endocrine and metabolic function of children born to PCOS mothers independently of the genetic inheritance and gender. The aim of the present study was to evaluate the reproductive and metabolic function in sons of women with PCOS during puberty. METHODS: Sixty nine PCOSs and 84 control sons (Cs) 7 to 18 years old matched by Tanner stage score were studied...
September 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28904307/irisin-is-a-biomarker-for-metabolic-syndrome-in-prepubertal-children
#8
Young Suk Shim, Min Jae Kang, Seung Yang, Il Tae Hwang
The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared to those with normal weight (p = 0...
September 12, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28900314/evaluation-of-metabolic-syndrome-and-related-factors-in-children-affected-by-acute-lymphoblastic-leukemia
#9
Soheila Zareifar, Sezaneh Haghpanah, Eslam Shorafa, Nader Shakibazad, Zohreh Karamizadeh
INTRODUCTION: Obesity is among the medical problems in survivors of childhood acute lymphoblastic leukemia (ALL). These patients are at risk of metabolic syndrome (MS). The present study aimed to follow the patients with ALL regarding the incidence of MS. PATIENTS AND METHODS: This study was conducted on all patients who referred to the oncology clinic from July 2012 to July 2013. The exclusion criteria of the study were ALL relapse, secondary malignancy, hypothyroidism, Down syndrome, and below 2 years of age...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28899517/metabolic-biomarkers-in-community-obese-children-effect-of%C3%A2-obstructive-sleep-apnea-and-its-treatment
#10
María Luz Alonso-Álvarez, Joaquin Terán-Santos, Mónica Gonzalez Martinez, José Aurelio Cordero-Guevara, María José Jurado-Luque, Jaime Corral-Peñafiel, Joaquin Duran-Cantolla, Estrella Ordax Carbajo, Fernando MasaJimenez, Leila Kheirandish-Gozal, David Gozal
OBJECTIVE: Obesity and obstructive sleep apnea in children have been associated with metabolic morbidities. The present study aimed to evaluate the presence of metabolic alterations among obese children recruited from the community, with and without obstructive sleep apnea syndrome (OSAS), and the impact of treatment of OSAS on metabolic profiles. METHODS: A cross-sectional, prospective, multicenter study of Spanish children aged 3-14 years with a body mass index (BMI) ≥95th percentile for age and sex were randomly selected in the first phase...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28898874/associations-between-liver-enzyme-levels-and-parameters-of-the-metabolic-syndrome-in-obese-children
#11
Christiane S Hampe, Michele L Shaffer, Christian L Roth
BACKGROUND: Obesity is strongly associated with insulin resistance, hypertension, dyslipidemia, and therefore risk for metabolic syndrome (MetS), which is an increasing problem in youth. The potential role of elevated liver enzyme levels in this context needs to be further investigated. METHODS: This paper provides a post hoc analysis of a cross-sectional study of 77 obese nondiabetic children (51% female; median age 11.7 years; BMI >97th percentile) enrolled at the University of Bonn, Bonn, Germany...
September 12, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28893745/a-new-risk-locus-in-chchd5-for-hypertension-and-obesity-in-a-chinese-child-population-a-cohort-study
#12
Lijun Wu, Liwang Gao, Xiaoyuan Zhao, Meixian Zhang, Jianxin Wu, Jie Mi
OBJECTIVE: Coiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), a mitochondrial protein, is involved in the oxidative folding process in the mitochondrial intermembrane space. A previous study identified a hypertension-related single nucleotide polymorphism (SNP), rs3748024, in CHCHD5 in adults, but there are no reports regarding the association between CHCHD5 and obesity, which is a known risk factor for hypertension. The aim of the present study is to investigate the associations of the SNP rs3748024 with hypertension and obesity...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28886253/female-offspring-born-to-obese-and-insulin-resistant-dams-are-not-at-increased-risk-for-obesity-and-metabolic-dysfunction-during-early-development
#13
Hanin Aburasayn, Rami Al Batran, Keshav Gopal, Malak Almutairi, Amina Eshreif, Farah Eaton, John Ussher
The percentage of women who are obese at the time of conception/pregnancy is increasing, with animal and human studies demonstrating that offspring born to obese dams/mothers are at increased risk for obesity and the metabolic syndrome. Our goal was to confirm in an experimental model of metabolic syndrome in the dam, whether the offspring would be at increased risk of obesity. Conversely, we observed that male offspring born to dams with metabolic syndrome had no alterations in their body weight profiles, whereas female offspring born to dams with metabolic syndrome were heavier at weaning, but exhibited no perturbations in energy metabolism...
September 8, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28885093/heart-rate-recovery-time-in-metabolically-healthy-and-metabolically-unhealthy-obese-children
#14
Ljiljana Bjelakovic, Vladimir Vukovic, Marko Jovic, Sanja Bankovic, Tomislav Kostic, Dragan Radovanovic, Sasa Pantelic, Mladen Zivkovic, Sanja Stojanovic, Bojko Bjelakovic
BACKGROUND: Autonomic dysfunction is an emerging non-traditional cardiovascular risk factor that correlates with obesity, components of metabolic syndrome, as well as cardiorespiratory fitness. As a simple and validated index of autonomic balance, heart rate recovery (HRR) has been reported as a useful biomarker for predicting cardiovascular morbidity and mortality. OBJECTIVES: The aim of this study was to compare HRR in metabolically healthy vs. metabolically unhealthy obese children...
September 8, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28881557/-early-adiposity-rebound-prevalence-and-the-effect-on-metabolic-risk-in-children
#15
H Cao, S Q Yan, F B Tao
The timing of the adiposity rebound (AR) gradually shifted to earlier ages throughout the world; early AR has a great effect on children's health, especially is possible associated with the development of metabolic disease for life, while the special mechanism isn't very clear. Metabolic diseases(MD) are common in adults, and the establishment of MD is the result of pathological chronic processes that can start in early life stages. If the metabolic risk factors and its predictive factors can be found in early childhood, it can bring forward the prevention and control of adult diseases...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28870583/a-new-infectious-encephalopathy-syndrome-clinically-mild-encephalopathy-associated-with-excitotoxicity-meex
#16
Nozomi Hirai, Daisuke Yoshimaru, Yoko Moriyama, Kumi Yasukawa, Jun-Ichi Takanashi
Acute infectious encephalopathy is often observed in children in East Asia including Japan. More than 40% of the patients remain unclassified into specific syndromes. To investigate the underlying pathomechanisms in those with unclassified encephalopathy, we evaluated brain metabolism by MR spectroscopy. Among seven patients with acute encephalopathy admitted to our hospital from June 2016 to May 2017, three were classified into acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). The other four showed consciousness disturbance lasting more than three days with no parenchymal lesion visible on MRI, which led to a diagnosis of unclassified encephalopathy...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28862940/childhood-age-and-associations-between-childhood-metabolic-syndrome-and-adult-risk-for-metabolic-syndrome-type-2-diabetes-mellitus-and-carotid-intima-media-thickness-the-international-childhood-cardiovascular-cohort-consortium
#17
Juha Koskinen, Costan G Magnussen, Alan Sinaiko, Jessica Woo, Elaine Urbina, David R Jacobs, Julia Steinberger, Ronald Prineas, Matthew A Sabin, Trudy Burns, Gerald Berenson, Lydia Bazzano, Alison Venn, Jorma S A Viikari, Nina Hutri-Kähönen, Olli Raitakari, Terence Dwyer, Markus Juonala
BACKGROUND: There is paucity of knowledge concerning the specific age in youth when the associations of metabolic syndrome (MetS) begin to be operative. Thus, we investigated the relation of age to the associations of childhood MetS with adult MetS, type 2 diabetes mellitus and high carotid intima-media thickness. METHODS AND RESULTS: Five thousand eight-hundred three participants were analyzed in 4 cohort studies (Cardiovascular Risk in Young Finns, Bogalusa Heart Study, Princeton Lipid Research Study, Insulin Study)...
August 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28862935/what-is-the-relationship-between-dairy-intake-and-blood-pressure-in-black-and-white-children-and-adolescents-enrolled-in-a-weight-management-program
#18
Diane M DellaValle, Janet Carter, Molly Jones, Melissa Howard Henshaw
BACKGROUND: The DASH (Dietary Approaches to Stop Hypertension) clinical trials and other studies have demonstrated a relationship between diet and cardiovascular outcomes in adults, yet little is known of this relationship in children. Childhood obesity has reached epidemic proportions in the United States, with similar increases in hypertension among this population. The purpose of our study was to examine the association between dairy intake and blood pressure (BP) in a cohort of children and adolescents (aged 4-17 years) enrolled in a weight management program...
August 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28860773/can-melatonin-prevent-or-improve-metabolic-side-effects-during-antipsychotic-treatments
#19
Maria-Cristina Porfirio, Juliana Paula Gomes de Almeida, Maddalena Stornelli, Silvia Giovinazzo, Diane Purper-Ouakil, Gabriele Masi
In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28842671/prevalence-of-hyperuricemia-and-its-related-risk-factors-among-preschool-children-from-china
#20
Nan Li, Shuang Zhang, Weiqin Li, Leishen Wang, Huikun Liu, Wei Li, Tao Zhang, Gongshu Liu, Yuexin Du, Junhong Leng
To estimate the prevalence of hyperuricemia and its major risk factors among Chinese preschool children. A cross-sectional survey was carried out in six central urban districts of Tianjin from March to June 2015. A cluster sampling was employed to obtain a random sample of preschool children. A total of 4073 children aged from 3 to 6 years participated in this survey. Logistic regression was used to obtain odds ratios and 95% confidence intervals. The overall mean serum uric acid concentrations was 243.0 ± 53...
August 25, 2017: Scientific Reports
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