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https://www.readbyqxmd.com/read/29169085/combined-toxicity-of-triclosan-2-4-dichlorophenol-and-2-4-6-trichlorophenol-to-zebrafish-danio-rerio
#1
Yuhuan Zhang, Mi Liu, Jinfeng Liu, Xuedong Wang, Caihong Wang, Weiming Ai, Shaobo Chen, Huili Wang
Triclosan (TCS), 2,4,6-trichlorophenol (2,4,6-TCP) and 2,4-dichlorophenol (2,4-DCP) are the most prevalent chlorinated phenolic pollutants in aquatic environments. Our results showed LC50 and EC50 values of 0.51, 1.11, 2.45mg/L, and 0.36, 0.74, 1.53mg/L for TCS, 2,4,6-TCP and 2,4-DCP, respectively, to 120hpf zebrafish. The highest TCSD (the mixture of TCS, 2,4,6-TCP and 2,4-DCP) toxicity was observed at a TCS:2,4,6-TCP:2,4-DCP concentration ratio of 1:2:4. LC50 and EC50 values of TCSD mixtures for 120-hpf zebrafish were 2...
November 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29168982/n-terminomics-reveals-control-of-arabidopsis-seed-storage-proteins-and-proteases-by-the-arg-n-end-rule-pathway
#2
Hongtao Zhang, Lucy Gannon, Kirsty L Hassall, Michael J Deery, Daniel J Gibbs, Michael J Holdsworth, Renier A L van der Hoorn, Kathryn S Lilley, Frederica L Theodoulou
The N-end rule pathway of targeted protein degradation is an important regulator of diverse processes in plants but detailed knowledge regarding its influence on the proteome is lacking. To investigate the impact of the Arg/N-end rule pathway on the proteome of etiolated seedlings, we used terminal amine isotopic labelling of substrates with tandem mass tags (TMT-TAILS) for relative quantification of N-terminal peptides in prt6, an Arabidopsis thaliana N-end rule mutant lacking the E3 ligase PROTEOLYSIS6 (PRT6)...
November 23, 2017: New Phytologist
https://www.readbyqxmd.com/read/29168868/structural-elucidation-and-immunostimulatory-activity-of-a-new-polysaccharide-from-cordyceps-militaris
#3
Sixue Bi, Yongshuai Jing, Qinqin Zhou, Xianjing Hu, Jianhua Zhu, Zhongyi Guo, Liyan Song, Rongmin Yu
A new polysaccharide (CMPB90-1) was isolated from cultured Cordyceps militaris by alkaline extraction. The chemical structure of CMPB90-1 was determined by analysis of physicochemical and spectral data. The backbone of CMPB90-1 is composed of (1→6)-linked α-d-glucopyranosyl and (1→3)-linked α-d-glucopyranosyl residues, with branching at O-6, which consists of (1→4)-linked β-d-mannopyranosyl and (1→6)-linked α-d-glucopyranosyl residues, respectively. β-d-Galactopyranosyl residues is the terminal unit...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168661/spatio-temporal-dynamics-of-cerebral-capillary-segments-with-stalling-red-blood-cells
#4
Şefik Evren Erdener, Jianbo Tang, Amir Sajjadi, Kıvılcım Kılıç, Sreekanth Kura, Chris B Schaffer, David A Boas
Optical coherence tomography (OCT) allows label-free imaging of red blood cell (RBC) flux within capillaries with high spatio-temporal resolution. In this study, we utilized time-series OCT-angiography to demonstrate interruptions in capillary RBC flux in mouse brain in vivo. We noticed ∼7.5% of ∼200 capillaries had at least one stall in awake mice with chronic windows during a 9-min recording. At any instant, ∼0.45% of capillaries were stalled. Average stall duration was ∼15 s but could last over 1 min...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29168532/complete-tetraglycosylation-of-a-calix-4-arene-by-a-chemo-enzymatic-approach
#5
Silvia Bernardi, Dong Yi, Ning He, Alessandro Casnati, Wolf-Dieter Fessner, Francesco Sansone
Polyglycosylated calixarenes are efficient and selective multivalent ligands for lectins. However, the chemical decoration of these macrocyclic scaffolds with saccharides of increasing complexity is hampered by the highly complex chemistry of carbohydrates. An alternative to the conventional approach is the enzymatic diversification of simple glycocluster-presented glycans. In this work, we present a highly efficient chemo-enzymatic approach to tetra-N-acetyl-lactosaminylcalix[4]arene via glycan extension catalyzed by a human β-1,4-galactosyltransferase...
November 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29168518/nb-and-ta-benzotriazole-or-benzoxazole-phenoxide-complexes-as-catalysts-for-the-ring-opening-polymerization-of-glycidol-to-synthesize-hyperbranched-polyglycerols
#6
Sreenath Pappuru, Debashis Chakraborty, Venkatachalam Ramkumar
A series of novel mononuclear (1a-7a and 1b-6b) as well as tetranuclear (8a and 9a) niobium (Nb) and tantalum (Ta) complexes of benzotriazole or benzoxazole phenoxide pro-ligands bearing different substituents at the ortho and para positions of the phenol rings were synthesized and characterized. The reaction of NbCl5 or TaCl5 with one equivalent of benzotriazole or benzoxazole phenoxide pro-ligands (L1H-L6H) in dry toluene or chloroform produced the corresponding chloride (1a-6a and 1b-6b) and ethoxy (7a) mononuclear Nb and Ta complexes in high yields...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29168517/crossed-beam-polyatomic-reaction-dynamics-recent-advances-and-new-insights
#7
REVIEW
Huilin Pan, Kopin Liu, Adriana Caracciolo, Piergiorgio Casavecchia
Over the past ten years or so, great advances in our understanding of the dynamics of elementary (bimolecular) polyatomic reactions in the gas-phase have occurred. This has been made possible by critical improvements (a) in crossed molecular beam (CMB) instruments with rotating mass spectrometric detection and time-of-flight analysis, especially following the implementation of soft ionization (by tunable low energy electrons or vacuum-ultraviolet synchrotron radiation) for product detection with increased sensitivity and universal detection power, and (b) in REMPI-slice velocity map ion imaging (VMI) detection techniques in pulsed CMB experiments for obtaining product pair-correlated information through high-resolution measurements directly in the center of mass system...
November 23, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29168502/a-gut-bacterial-pathway-metabolizes-aromatic-amino-acids-into-nine-circulating-metabolites
#8
Dylan Dodd, Matthew H Spitzer, William Van Treuren, Bryan D Merrill, Andrew J Hryckowian, Steven K Higginbottom, Anthony Le, Tina M Cowan, Garry P Nolan, Michael A Fischbach, Justin L Sonnenburg
The human gut microbiota produces dozens of metabolites that accumulate in the bloodstream, where they can have systemic effects on the host. Although these small molecules commonly reach concentrations similar to those achieved by pharmaceutical agents, remarkably little is known about the microbial metabolic pathways that produce them. Here we use a combination of genetics and metabolic profiling to characterize a pathway from the gut symbiont Clostridium sporogenes that generates aromatic amino acid metabolites...
November 22, 2017: Nature
https://www.readbyqxmd.com/read/29168462/potential-benefit-of-optimizing-atrioventricular-interventricular-delays-in-patients-with-cardiac-resynchronization-therapy
#9
Bozena Urbanek, Krzysztof Kaczmarek, Artur Klimczak, Jan Ruta, Michal Chudzik, Katarzyna Piestrzeniewicz, Pawel Ptaszynski, Jerzy Krzysztof Wranicz
BACKGROUND & OBJECTIVES: The clinical benefit of optimization (OPT) of atrioventricular delay (AVD) and interventricular delay (VVD) in cardiac resynchronization therapy (CRT) remains debatable. This study was aimed to determine the influence of AVD and VVD OPT on selected parameters in patients early after CRT implantation and at mid-term follow up (FU). METHODS: Fifty two patients (61±10 yr, 23 males) with left bundle branch block, left ventricular ejection fraction (LVEF) ≤35 per cent and heart failure were selected for CRT implantation...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168109/a-case-of-glomangiopericytoma-at-the-nasal-septum
#10
Takashi Anzai, Tsuyoshi Saito, Sho Tsuyama, Miri Toh, Katsuhisa Ikeda, Shin Ito
Glomangiopericytoma (GPC) is a rare sinonasal perivascular tumor that accounts for < 0.5-1% of all sinonasal tumors. GPC is categorized as a low-grade neoplasm with borderline malignancy and a tendency of local recurrence. GPC is a rare mesenchymal neoplasm characterized by the perivascular proliferation of tumor cells, and it requires being distinguished from solitary fibrous tumors. Here, we report a case of GPC in a 68-year-old male patient who presented at the emergency room of our hospital with a complaint of sudden epistaxis...
November 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29168108/the-malaris-muscle-its-morphological-significance-for-sustaining-the-intraorbital-structures
#11
Natnicha Kampan, Masahiro Tsutsumi, Itsuko Okuda, Hisayo Nasu, Mi-Sun Hur, Kumiko Yamaguchi, Keiichi Akita
The orbicularis oculi muscle, an important mimetic muscle, was investigated to ascertain its anatomical relation to facial aging-especially its orbital part (Oo). Previous studies of the distinct muscle bundles frequently found inferior to the Oo have provided various definitions, including that of the malaris muscle. This study aimed to examine these muscle bundles and clarify their function in facial aging. Twelve heads of Japanese cadavers (average age: 82.5 years old) were dissected to observe the muscles, focusing in particular on those in the periorbital region...
November 22, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/29167981/transcriptional-induction-of-two-phosphate-transporter-1-genes-and-enhanced-root-branching-in-grape-plants-inoculated-with-funneliformis-mosseae
#12
Laure Valat, Laurence Deglène-Benbrahim, Melha Kendel, Réjane Hussenet, Christine Le Jeune, Paul Schellenbaum, Pascale Maillot
We investigated the effects of the arbuscular mycorrhizal fungus (AMF) Funneliformis mosseae on the growth and root architecture of plantlets of the grape rootstock 41B MGt under hydroponic conditions, and analyzed the concomitant expression of putative mycorrhizal-specific phosphate transporter 1 (PHT1) genes. In vitro propagated plantlets were acclimatized to ex vitro culture before AMF inoculation and grown under low phosphate (Pi) nutrition conditions during 6 weeks. Grape roots could be efficiently colonized by F...
November 22, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/29167899/comparative-effectiveness-of-resection-vs-surveillance-for-pancreatic-branch-duct-intraductal-papillary-mucinous-neoplasms-with-worrisome-features
#13
Yinin Hu, Lily E Johnston, Vanessa M Shami, Todd W Bauer, Reid B Adams, George J Stukenborg, Victor M Zaydfudim
Importance: The 2012 international consensus guidelines defined a subcategory of pancreatic branch duct intraductal papillary mucinous neoplasms with "worrisome features," which may be followed with close surveillance. However, given the poor prognosis of invasive malignancy, the role of early, upfront resection requires further investigation. Objective: To compare the utility of upfront resection vs long-term surveillance. We hypothesized that surveillance of these cystic neoplasms would offer greater long-term utility...
November 22, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29167876/branch-duct-intraductal-papillary-mucinous-neoplasms-how-worried-should-we-be-about-worrisome-features
#14
Salila S Hashmi, David A Kooby
No abstract text is available yet for this article.
November 22, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29167680/gene-editing-and-crop-improvement-using-crispr-cas9-system
#15
REVIEW
Leena Arora, Alka Narula
Advancements in Genome editing technologies have revolutionized the fields of functional genomics and crop improvement. CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat)-Cas9 is a multipurpose technology for genetic engineering that relies on the complementarity of the guideRNA (gRNA) to a specific sequence and the Cas9 endonuclease activity. It has broadened the agricultural research area, bringing in new opportunities to develop novel plant varieties with deletion of detrimental traits or addition of significant characters...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29167624/unique-ventricular-tachycardia-originating-from-the-right-bundle-branch
#16
Hongliang Yang, Daoyuan Si, Yaliang Tong, Zhe An, Ping Yang, Yuquan He
Ventricular tachycardia (VT), a common arrhythmia, frequently originates from in the right ventricular outflow tract, left ventricular outflow tract, aortic sinus, and left ventricular papillary muscle but infrequently from the His-Purkinje system, whereas the VT stemming from the right bundle branch has rarely been reported. Here we reported a case with of VT originating from the right bundle branch which was subsequently successfully treated with radiofrequency ablation and demonstrated the electrocardiac features of VT using an electrophysiological examination...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167617/statin-attenuated-myocardial-inflammation-induced-by-pm2-5-in-rats
#17
Hongmei Yao, Jiyuan Lv
Background: Here, the study aims to explore the effect of PM2.5 exposure on atherosclerosis in rats. Materials and Methods: 32 Wistar rats were selected in our study. An atherosclerosis model was established. All rats were evenly divided into four groups, including normal control group (NC), model control group (MC), model PM2.5 group (PM2.5) and model Atorvastatin group (Atorvastatin). The rats in NC and model control group were treated with saline 1 ml/kg body weight by tail intravenous injection, while the rats in PM2...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167274/distinct-cellular-mechanisms-underlie-smooth-muscle-turnover-in-vascular-development-and-repair
#18
Urmas Roostalu, Bashar Aldeiri, Alessandra Albertini, Neil E Humphreys, Maj Simonsen-Jackson, Jason K Wong, Giulio Cossu
Rationale: Vascular smooth muscle turnover has important implications for blood vessel repair and for the development of cardiovascular diseases, yet lack of specific transgenic animal models has prevented it's in vivo analysis. Objective: To characterize the dynamics and mechanisms of vascular smooth muscle turnover from the earliest stages of embryonic development to arterial repair in the adult. Methods and Results: We show that CD146 is transiently expressed in vascular smooth muscle development. By using CRISPR-Cas9 genome editing and in vitro smooth muscle differentiation assay we demonstrate that CD146 regulates the balance between proliferation and differentiation...
November 22, 2017: Circulation Research
https://www.readbyqxmd.com/read/29167270/ubia-prenyltransferase-domain-containing-protein-1-modulates-hmg-coa-reductase-degradation-to-coordinate-synthesis-of-sterol-and-nonsterol-isoprenoids
#19
Marc M Schumacher, Dong-Jae Jun, Brittany M Johnson, Russell A DeBose-Boyd
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2. We previously reported that sterols stimulate binding of UBIAD1 to endoplasmic reticulum (ER)-localized HMG CoA reductase. UBIAD1 binding inhibits sterol-accelerated, ER-associated degradation (ERAD) of reductase, one of several mechanisms for feedback control of this rate-limiting enzyme in the branched pathway that produces cholesterol and nonsterol isoprenoids such as GGpp. Accumulation of GGpp in ER membranes triggers release of UBIAD1 from reductase, permitting its maximal ERAD and ER-to-Golgi transport of UBIAD1...
November 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29167198/comparative-transcriptome-analysis-reveals-conserved-branching-morphogenesis-related-genes-involved-in-chamber-formation-of-catfish-swimbladder
#20
Yujia Yang, Qiang Fu, Yang Liu, Xiaozhu Wang, Rex Dunham, Shikai Liu, Lisui Bao, Qifan Zeng, Tao Zhou, Ning Li, Zhenkui Qin, Chen Jiang, Dongya Gao, Zhanjiang Liu
The swimbladder is an internal gas-filled organ in teleosts. Its major function is to regulate buoyancy. Swimbladder exhibits great variations in size, shape, number of compartments or chambers among teleosts. However, the genomic control of swimbladder variations is unknown. Channel catfish (Ictalurus punctatus), blue catfish (Ictalurus furcatus), and their F1 hybrids of female channel catfish x male blue catfish (C×B hybrid catfish) provide a good model to investigate the swimbladder morphology, because channel catfish possess a single-chambered swimbladder whereas blue catfish possess a bi-chambered swimbladder; and C×B hybrid catfish possess a bi-chambered swimbladder but with significantly reduced posterior chamber...
November 22, 2017: Physiological Genomics
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