Tianlu Chen, Fengfeng Pan, Qi Huang, Guoxiang Xie, Xiaowen Chao, Lirong Wu, Jie Wang, Liang Cui, Tao Sun, Mengci Li, Ying Wang, Yihui Guan, Xiaojiao Zheng, Zhenxing Ren, Yuhuai Guo, Lu Wang, Kejun Zhou, Aihua Zhao, Qihao Guo, Fang Xie, Wei Jia
The metabolic implications in Alzheimer's disease (AD) remain poorly understood. Here, we conducted a metabolomics study on a moderately aging Chinese Han cohort (n = 1397; mean age 66 years). Conjugated bile acids, branch-chain amino acids (BCAAs), and glutamate-related features exhibited strong correlations with cognitive impairment, clinical stage, and brain amyloid-β deposition (n = 421). These features demonstrated synergistic performances across clinical stages and subpopulations and enhanced the differentiation of AD stages beyond demographics and Apolipoprotein E ε4 allele (APOE-ε4)...
May 7, 2024: Nature Communications