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https://www.readbyqxmd.com/read/28616351/hybrid-aortic-repair-with-antegrade-supra-aortic-and-renovisceral-debranching-from-ascending-aorta
#1
José Antonio Del Castro-Madrazo, Margarita Rivas-Domínguez, Carlota Fernández-Prendes, Amer Zanabili Al-Sibbai, José Manuel Llaneza-Coto, Manuel Alonso-Pérez
Aortic dissection is a life threatening condition. Hybrid repair has been described for the treatment of complex aortic pathology such as thoracoabdominal aortic aneurysms (TAAA) and type A and B dissections, although open and total endovascular repair are also possible. Open surgery is still associated with substantial perioperative morbi-mortality rates, thus less invasive techniques such as endovascular repair and hybrid procedures can achieve good results in centers with experience. We present the case of a patient with a chronic type B dissection and TAAA degeneration that was treated in a single stage hybrid procedure with antegrade supra-aortic and renovisceral debranching from the ascending aorta and TEVAR...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28616343/debranching-aortic-surgery
#2
REVIEW
Manuel Alonso Pérez, José Manuel Llaneza Coto, José Antonio Del Castro Madrazo, Carlota Fernández Prendes, Mario González Gay, Amer Zanabili Al-Sibbai
Conventional open surgery still remains as the gold standard of care for aortic arch and thoracoabdominal pathology. In centers of excellence, open repair of the arch has been performed with 5% immediate mortality and a low rate of complications; however overall mortality rates are around 15%, being up to 40% of all patients rejected for treatment due to their age or comorbidities. For thoracoabdominal aortic pathology, data reported from centers of excellence show immediate mortality rates from 5% to 19%, spinal cord ischemia from 2...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28610926/effects-of-single-and-co-immobilization-on-the-product-specificity-of-type-i-pullulanase-from-anoxybacillus-sp-sk3-4
#3
Ummirul Mukminin Kahar, Kok-Gan Chan, Mohd Helmi Sani, Nur Izzati Mohd Noh, Kian Mau Goh
Type I pullulanase from Anoxybacillus sp. SK3-4 (PulASK) is an unusual debranching enzyme that specifically hydrolyzes starch α-1,6 linkages at long branches producing oligosaccharides (≥G8), but is nonreactive against short branches; thus, incapable of producing reducing sugars (G1-G7). We report on the effects of both single and co-immobilization of PulASK on product specificity. PulASK was purified and immobilized through covalent attachment to three epoxides (ReliZyme EP403/M, Immobead IB-150P, and Immobead IB-150A) and an amino-epoxide (ReliZyme HFA403/M) activated supports...
June 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28595218/-disruption-of-matsui-kitamura-stent-graft-six-years-after-treatment-for-rupture-of-thoracic-aortic-aneurysm
#4
Takahiro Ishigaki, Hitoshi Matsuda, Ryuta Kawasaki, Soichiro Henmi, Hidekazu Nakai, So Izumi, Masamichi Matsumori, Hirohisa Murakami, Tasuku Honda, Masato Yoshida, Nobuhiko Mukohara
Matsui-Kitamura stent-graft (MKSG) is a home-made device for thoracic endovascular aortic repair (TEVAR) developed in Japan. A 76-year-old man who had been treated by TEVAR (zone 3) with a MKSG for ruptured thoracic aortic aneurysm was diagnosed as having type Ia endoleak caused by suture disruption and aneurysmal sac expansion 6 years later. He underwent TEVAR (zone 1) with debranching and type Ia endoleak disappeared. MKSG had been the effective device especially for acute aortic emergencies in the descending thoracic aorta until the stent-grafts became commercially available, but careful observation and appropriate re-intervention is mandatory for the continued life-saving contribution...
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28594811/-successful-two-stage-surgical-treatment-of-a-thoracoabdominal-aortic-aneurysm-a-case-report
#5
V V Shlomin, D A Zverev, E D Zvereva, P D Puzdriak, P B Bondarenko, M L Gordeev
Presented herein is a clinical case report regarding hybrid or two-stage surgical treatment of a Crawford type II thoracoabdominal aortic aneurysm in an 87-year-old woman. For the first stage operation we performed open resection of the abdominal aortic aneurysm with aortofemoral bifurcation prosthetic repair and debranching of visceral and renal arteries. Several months thereafter, the second stage operation was performed, consisting in transcatheter exclusion of the thoracoabdominal aortic aneurysm with the help of two stent grafts...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28584628/involvement-of-glycogen-debranching-enzyme-in-bladder-cancer
#6
Benjamin Weinhaus, Sunny Guin
Bladder cancer is the most common malignancy of the urinary system, however the molecular pathways underlying this disease are incompletely understood. To understand new regulators of bladder cancer progression, the authors carried out a functional genomic screen which identified glycogen debranching enzyme (AGL) as a novel regulator of bladder cancer growth. Glycogen debranching enzyme is involved in glycogen breakdown and germline loss of function mutation of this gene leads to glycogen storage disease type III...
June 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28554014/investigation-of-debranching-pattern-of-a-thermostable-isoamylase-and-its-application-for-the-production-of-resistant-starch
#7
Youran Li, Jingjing Xu, Liang Zhang, Zhongyang Ding, Zhenghua Gu, Guiyang Shi
Debranching enzymes contribute to the enzymatic production of resistant starch (RS) by reducing substrate molecular weight and increasing amylose yield. In the present study, the action pattern of a thermostable isoamylase-type debranching enzyme on different types of starch was investigated. The molecular weight distribution, glycosidic bond composition and contents of oligosaccharides released were monitored by various liquid chromatography techniques and nuclear magnetic resonance spectroscopy (NMR). These analyses showed that the isoamylase could specifically and efficiently attack α-1,6-glucosidic linkages at branch points, leaving the amylose favored by other amylolytic enzymes...
May 22, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28516092/frozen-elephant-trunk-and-antegrade-visceral-debranching-in-the-surgical-treatment-of-type-b-aortic-dissection-an-alternative-method
#8
Altug Tuncer, Mustafa Akbulut, Taylan Adademir, Serpil Tas, Adnan Ak, Özgür Arslan, Benay Erden, Mesut Şişmanoğlu
Intervention is inevitable in complicated Type B aortic dissections. Classical surgical procedures and endovascular interventions are far from ideal treatments due to their high risk of periprocedural complications and mortality. There is often a need for alternative method in cases of difficult anatomy. We present the combined use of frozen elephant trunk and antegrade visceral debranching methods in the treatment of a 54-year-old male patient with complicated Type B aortic dissection.
October 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28504715/human-dbr1-modulates-the-recycling-of-snrnps-to-affect-alternative-rna-splicing-and-contributes-to-the-suppression-of-cancer-development
#9
B Han, H K Park, T Ching, J Panneerselvam, H Wang, Y Shen, J Zhang, L Li, R Che, L Garmire, P Fei
The contribution of RNA processing to tumorigenesis is understudied. Here, we report that the human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces oncogenesis by causing RNA processing defects, for example, splicing defects. We found that wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression, and insufficient hDBR1 leads to a higher rate of exon skipping. Transcriptomic sequencing confirmed the effect of hDBR1 on RNA splicing, and metabolite profiling supported the observation that neoplasm is triggered by a decrease in hDBR1 expression both in vitro and in vivo...
May 15, 2017: Oncogene
https://www.readbyqxmd.com/read/28504306/crystal-structure-of-the-entamoeba-histolytica-rna-lariat-debranching-enzyme-ehdbr1-reveals-a-catalytic-zn-2-mn-2-heterobinucleation
#10
Elizabeth Ransey, Eduardo Paredes, Sourav K Dey, Subha R Das, Annie Heroux, Mark R Macbeth
The RNA lariat debranching enzyme Dbr1 is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni(2+) , Mn(2+) , Mg(2+) , Fe(2+) and Zn(2+) . While in initial structures of the Entamoeba histolytica Dbr1 only one of the two catalytic metal-binding sites were observed to be occupied (with a Mn(2+) ion), recent structures determined a Zn(2+) /Fe(2+) heterobinucleation...
May 15, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28504155/structural-and-physicochemical-properties-of-granular-starches-after-treatment-with-debranching-enzyme
#11
Ping Li, Xiaowei He, Sushil Dhital, Bin Zhang, Qiang Huang
The present study modified maize and potato granular starches by partial debranching treatment below the gelatinization temperature, and investigated their structural and physicochemical properties. Pullulanase was much effective (more than three times) on hydrolyzing potato starch compared to maize starch as measured from total carbohydrate values in the supernatant. The pullulanase hydrolysis decreased the amount of double helices as observed from DSC measurement. These effects were dependent upon the time of enzyme hydrolysis (24h>8h>1h) as well as type of starch (potato>maize)...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28495534/hybrid-treatment-of-the-aberrant-right-subclavian-artery-arteria-lusoria-feasibility-study-on-180-angio-cts
#12
Nicla Settembre, Charbel Saba, Zakariyae Bouziane, Fanette Jeannon, Damien Mandry, Serguei Malikov
OBJECTIVES: The aberrant right subclavian artery or arteria lusoria (AL) is the most frequent anatomical variation of the supra-aortic trunks (SAT). Treatment is only warranted in presence of an aneurysm because of the risk of rupture or in symptomatic cases with signs of compression of the esophagus or the trachea, with embolisms causing right upper limb ischemia of vertebrobasilar cerebrovascular accidents (CVA). The conventional surgical treatment of AL is the closure of the origin of AL and the revascularization of the artery right subclavian through a left thoracotomy...
May 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28479429/postoperative-dysphagia-in-debranching-tevar-with-retroesophageal-carotid-carotid-bypass
#13
Fumiya Yoneyama, Fujio Sato, Chiho Tokunaga, Hiroaki Sakamoto, Yoshiharu Enomoto, Yutaka Watanabe, Yuji Hiramatsu
A carotid-carotid bypass is commonly used in debranching thoracic endovascular aortic repair. When the bypass graft is placed in the retroesophageal position, the esophagus may be compressed by the graft from behind. Therefore, dysphagia may occur postoperatively as a serious complication. To avoid this issue, we recommend placing the bypass graft below the cricoid cartilage.
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28457958/effect-of-diurnal-photosynthetic-activity-on-the-fine-structure-of-amylopectin-from-normal-and-waxy-barley-starch
#14
Avi Goldstein, George Annor, Andreas Blennow, Eric Bertoft
The impact of diurnal photosynthetic activity on the fine structure of the amylopectin fraction of starch synthesized by normal barley (NBS) and waxy barley (WBS), the latter completely devoid of amylose biosynthesis, was determined following the cultivation under normal diurnal or constant light growing conditions. The amylopectin fine structures were analysed by characterizing its unit chain length profiles after enzymatic debranching as well as its φ,β-limit dextrins and its clusters and building blocks after their partial and complete hydrolysis with α-amylase from Bacillus amyloliquefaciens, respectively...
April 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28433770/preparation-of-low-digestible-and-viscoelastic-tigernut-cyperus-esculentus-starch-by-bacillus-acidopullulyticus-pullulanase
#15
Xiaolei Li, Jingchao Fu, Yujuan Wang, Fumin Ma, Dan Li
Tigernut starch is an underutilized food resource. In this study, pullulanase (PUL) hydrolysis was used to change its physiochemical properties for different food applications. The content of low digestible fractions, resistant starch and slow digestible starch, in PUL modified tigernut starch significantly increased from 2.03% to 25.08% (P<0.05) using 100U/g starch of PUL in the debranching reaction. The paste or dispersion of PUL modified tigernut starch had a significantly decreased viscoelasticity (P<0...
April 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28431720/hybrid-endovascular-repair%C3%A2-of%C3%A2-a-right-sided-thoracoabdominal-aortic%C3%A2-aneurysm
#16
Mamoru Hamuro, Tomoyuki Yamada, Kenji Yamamoto, Sakae Enomoto, Masahide Kawatou
A right-sided thoracoabdominal aortic aneurysm involving a right-sided aortic arch is extremely rare. Surgical treatment for a right-sided thoracoabdominal aortic aneurysm is challenging due to the anatomical complexity. We report a case of a right-sided thoracoabdominal aortic aneurysm with a right-sided aortic arch successfully treated by hybrid visceral debranching and endovascular repair.
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28429930/enzymatically-debranched-xylans-in-graft-copolymerization
#17
Kuisma Littunen, Galina Mai-Gisondi, Jukka Seppälä, Emma R Master
Wheat arabinoxylan was treated with two α-arabinofuranosidases exhibiting different mode of action to create three different polymeric substrates. These three substrate preparations were characterized by xylopyranose backbone sugars that are (1) singly substituted by arabinose at C2 or C3, (2) doubly substituted by arabinose at C2 and C3, and (3) largely unsubstituted. All xylan preparations were grafted with glycidyl methacrylate using cerium ammonium nitrate and then evaluated in terms of graft yield and adsorption to cellulose surfaces...
April 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28428528/-challenge-of-treating-thoracoabdominal-aortic-aneurysms-with-hybrid-thoracic-endovascular-aortic-repair
#18
Takashi Shuto, Shinji Miyamoto
The treatment of thoracoabdominal aortic aneurysms in great vessels is still challenging, as the early results of the operation are not very promising compared with other aortic operations, and the incidence of spinal cord ischemia is relatively high. In Japan, which is becoming a super-aging society, the method of performing minimally invasive operations remains a major issue. At our facility, we have been performing abdominal debranching thoracic endovascular aortic repair (TEVAR) to resolve these issues...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28428524/-hybrid-thoracic-endovascular-aortic-repair-with-total-debranching-of-supra-aortic-trunks
#19
Yoshimasa Seike, Hiroshi Tanaka, Hitoshi Matsuda
The method of hybrid arch thoracic endovascular aortic repair (TEVAR) to treat aneurysm with zone 0 landing has changed according to its invasiveness and complications. The real chimney technique allows supra-aortic bypass from ascending aorta without side clamp is the current choice of treatment. The comprehensive strategy to prevent stroke during hybrid arch TEVAR consisting of magnetization-prepared rapid acquisition with gradient-echo for evaluation of the atheromatous change and balloon protection of the left subclavian artery has contributed for the marked reduction of stroke...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28428523/-efficacy-of-total-debranching-thoracic-endovascular-aortic-repair-for-the-re-operation-of-aortic-arch-aneurysm
#20
Kyohei Ueno, Megumu Kanno, Hirofumi Midorikawa, Gaku Takinami, Rie Kageyama
Thoracic endovascular aortic repair (TEVAR) combined with all-neck-branch reconstruction (total debranching TEVAR)[td TEVAR] is applied to aortic arch aneurysms as a minimally invasive procedure to improve treatment results. We report the initial and long-term results of td TEVAR for the reoperation of aortic arch aneurysm. By September 2016, td TEVAR for reoperation had been applied in 5 cases. The reasons for the reoperation were dilation of the arch aneurysm after ascending aorta replacement in 4 cases and localized dissection of the proximal landing zone after zone 2 TEVAR in 1 case...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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