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https://www.readbyqxmd.com/read/28516092/frozen-elephant-trunk-and-antegrade-visceral-debranching-in-the-surgical-treatment-of-type-b-aortic-dissection-an-alternative-method
#1
Altug Tuncer, Mustafa Akbulut, Taylan Adademir, Serpil Tas, Adnan Ak, Özgür Arslan, Benay Erden, Mesut Şişmanoğlu
Intervention is inevitable in complicated Type B aortic dissections. Classical surgical procedures and endovascular interventions are far from ideal treatments due to their high risk of periprocedural complications and mortality. There is often a need for alternative method in cases of difficult anatomy. We present the combined use of frozen elephant trunk and antegrade visceral debranching methods in the treatment of a 54-year-old male patient with complicated Type B aortic dissection.
October 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28504715/human-dbr1-modulates-the-recycling-of-snrnps-to-affect-alternative-rna-splicing-and-contributes-to-the-suppression-of-cancer-development
#2
B Han, H K Park, T Ching, J Panneerselvam, H Wang, Y Shen, J Zhang, L Li, R Che, L Garmire, P Fei
The contribution of RNA processing to tumorigenesis is understudied. Here, we report that the human RNA debranching enzyme (hDBR1), when inappropriately regulated, induces oncogenesis by causing RNA processing defects, for example, splicing defects. We found that wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression, and insufficient hDBR1 leads to a higher rate of exon skipping. Transcriptomic sequencing confirmed the effect of hDBR1 on RNA splicing, and metabolite profiling supported the observation that neoplasm is triggered by a decrease in hDBR1 expression both in vitro and in vivo...
May 15, 2017: Oncogene
https://www.readbyqxmd.com/read/28504306/crystal-structure-of-the-entamoeba-histolytica-rna-lariat-debranching-enzyme-ehdbr1-reveals-a-catalytic-zn-2-mn-2-heterobinucleation
#3
Elizabeth Ransey, Eduardo Paredes, Sourav K Dey, Subha R Das, Annie Heroux, Mark R Macbeth
The RNA lariat debranching enzyme Dbr1 is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni(2+) , Mn(2+) , Mg(2+) , Fe(2+) and Zn(2+) . While in initial structures of the Entamoeba histolytica Dbr1 only one of the two catalytic metal-binding sites were observed to be occupied (with a Mn(2+) ion), recent structures determined a Zn(2+) /Fe(2+) heterobinucleation...
May 15, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28504155/structural-and-physicochemical-properties-of-granular-starches-after-treatment-with-debranching-enzyme
#4
Ping Li, Xiaowei He, Sushil Dhital, Bin Zhang, Qiang Huang
The present study modified maize and potato granular starches by partial debranching treatment below the gelatinization temperature, and investigated their structural and physicochemical properties. Pullulanase was much effective (more than three times) on hydrolyzing potato starch compared to maize starch as measured from total carbohydrate values in the supernatant. The pullulanase hydrolysis decreased the amount of double helices as observed from DSC measurement. These effects were dependent upon the time of enzyme hydrolysis (24h>8h>1h) as well as type of starch (potato>maize)...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28495534/hybrid-treatment-of-the-aberrant-right-subclavian-artery-arteria-lusoria-feasibility-study-on-180-angio-cts
#5
Nicla Settembre, Charbel Saba, Zakariyae Bouziane, Fanette Jeannon, Damien Mandry, Serguei Malikov
OBJECTIVES: The aberrant right subclavian artery or arteria lusoria (AL) is the most frequent anatomical variation of the supra-aortic trunks (SAT). Treatment is only warranted in presence of an aneurysm because of the risk of rupture or in symptomatic cases with signs of compression of the esophagus or the trachea, with embolisms causing right upper limb ischemia of vertebrobasilar cerebrovascular accidents (CVA). The conventional surgical treatment of AL is the closure of the origin of AL and the revascularization of the artery right subclavian through a left thoracotomy...
May 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28479429/postoperative-dysphagia-in-debranching-tevar-with-retroesophageal-carotid-carotid-bypass
#6
Fumiya Yoneyama, Fujio Sato, Chiho Tokunaga, Hiroaki Sakamoto, Yoshiharu Enomoto, Yutaka Watanabe, Yuji Hiramatsu
A carotid-carotid bypass is commonly used in debranching thoracic endovascular aortic repair. When the bypass graft is placed in the retroesophageal position, the esophagus may be compressed by the graft from behind. Therefore, dysphagia may occur postoperatively as a serious complication. To avoid this issue, we recommend placing the bypass graft below the cricoid cartilage.
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28457958/effect-of-diurnal-photosynthetic-activity-on-the-fine-structure-of-amylopectin-from-normal-and-waxy-barley-starch
#7
Avi Goldstein, George Annor, Andreas Blennow, Eric Bertoft
The impact of diurnal photosynthetic activity on the fine structure of the amylopectin fraction of starch synthesized by normal barley (NBS) and waxy barley (WBS), the latter completely devoid of amylose biosynthesis, was determined following the cultivation under normal diurnal or constant light growing conditions. The amylopectin fine structures were analysed by characterizing its unit chain length profiles after enzymatic debranching as well as its φ,β-limit dextrins and its clusters and building blocks after their partial and complete hydrolysis with α-amylase from Bacillus amyloliquefaciens, respectively...
April 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28433770/preparation-of-low-digestible-and-viscoelastic-tigernut-cyperus-esculentus-starch-by-bacillus-acidopullulyticus-pullulanase
#8
Xiaolei Li, Jingchao Fu, Yujuan Wang, Fumin Ma, Dan Li
Tigernut starch is an underutilized food resource. In this study, pullulanase (PUL) hydrolysis was used to change its physiochemical properties for different food applications. The content of low digestible fractions, resistant starch and slow digestible starch, in PUL modified tigernut starch significantly increased from 2.03% to 25.08% (P<0.05) using 100U/g starch of PUL in the debranching reaction. The paste or dispersion of PUL modified tigernut starch had a significantly decreased viscoelasticity (P<0...
April 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28431720/hybrid-endovascular-repair%C3%A2-of%C3%A2-a-right-sided-thoracoabdominal-aortic%C3%A2-aneurysm
#9
Mamoru Hamuro, Tomoyuki Yamada, Kenji Yamamoto, Sakae Enomoto, Masahide Kawatou
A right-sided thoracoabdominal aortic aneurysm involving a right-sided aortic arch is extremely rare. Surgical treatment for a right-sided thoracoabdominal aortic aneurysm is challenging due to the anatomical complexity. We report a case of a right-sided thoracoabdominal aortic aneurysm with a right-sided aortic arch successfully treated by hybrid visceral debranching and endovascular repair.
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28429930/enzymatically-debranched-xylans-in-graft-copolymerization
#10
Kuisma Littunen, Galina Mai-Gisondi, Jukka Seppälä, Emma R Master
Wheat arabinoxylan was treated with two α-arabinofuranosidases exhibiting different mode of action to create three different polymeric substrates. These three substrate preparations were characterized by xylopyranose backbone sugars that are (1) singly substituted by arabinose at C2 or C3, (2) doubly substituted by arabinose at C2 and C3, and (3) largely unsubstituted. All xylan preparations were grafted with glycidyl methacrylate using cerium ammonium nitrate and then evaluated in terms of graft yield and adsorption to cellulose surfaces...
April 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28428528/-challenge-of-treating-thoracoabdominal-aortic-aneurysms-with-hybrid-thoracic-endovascular-aortic-repair
#11
Takashi Shuto, Shinji Miyamoto
The treatment of thoracoabdominal aortic aneurysms in great vessels is still challenging, as the early results of the operation are not very promising compared with other aortic operations, and the incidence of spinal cord ischemia is relatively high. In Japan, which is becoming a super-aging society, the method of performing minimally invasive operations remains a major issue. At our facility, we have been performing abdominal debranching thoracic endovascular aortic repair (TEVAR) to resolve these issues...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28428524/-hybrid-thoracic-endovascular-aortic-repair-with-total-debranching-of-supra-aortic-trunks
#12
Yoshimasa Seike, Hiroshi Tanaka, Hitoshi Matsuda
The method of hybrid arch thoracic endovascular aortic repair (TEVAR) to treat aneurysm with zone 0 landing has changed according to its invasiveness and complications. The real chimney technique allows supra-aortic bypass from ascending aorta without side clamp is the current choice of treatment. The comprehensive strategy to prevent stroke during hybrid arch TEVAR consisting of magnetization-prepared rapid acquisition with gradient-echo for evaluation of the atheromatous change and balloon protection of the left subclavian artery has contributed for the marked reduction of stroke...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28428523/-efficacy-of-total-debranching-thoracic-endovascular-aortic-repair-for-the-re-operation-of-aortic-arch-aneurysm
#13
Kyohei Ueno, Megumu Kanno, Hirofumi Midorikawa, Gaku Takinami, Rie Kageyama
Thoracic endovascular aortic repair (TEVAR) combined with all-neck-branch reconstruction (total debranching TEVAR)[td TEVAR] is applied to aortic arch aneurysms as a minimally invasive procedure to improve treatment results. We report the initial and long-term results of td TEVAR for the reoperation of aortic arch aneurysm. By September 2016, td TEVAR for reoperation had been applied in 5 cases. The reasons for the reoperation were dilation of the arch aneurysm after ascending aorta replacement in 4 cases and localized dissection of the proximal landing zone after zone 2 TEVAR in 1 case...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28428522/-surgeon-modified-fenestrated-thoracic-endovascular-aortic-repair-for-the-treatment-of-aortic-aneurysm
#14
Kenichi Hashizume, Hideyuki Shimizu
Thoracic endovascular aortic repair( TEVAR) for thoracic aortic aneurysm has been established as a 1st-line therapy, especially in high-risk cases, with device improvements and the appearance of various procedures, but there are still cases of anatomical adaptation. On the other hand, several countermeasures have been developed, but there are no commercially available devices for fenestrated or branched stent grafts in Japan. Moreover, complications such as cerebral infarction, organ ischemia and bypass occlusion and infection are pointed out in popular debranch TEVAR...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28428519/-current-status-of-thoracic-endovascular-aortic-repair-in-our-institution
#15
Daisuke Fukui, Kenji Okada
Within 8-year period between 2009 and 2016, we treated 215 patient with a strategy of primary thoracic endovascular aortic repair( TEVAR). In-hospital mortality was 4.4%( 8 cases). Thirty-two emergency cases was included and we treated 23 cases of zone 0 debranching TEVAR with chimney techinique in this period. In recent 2-year period between 2015 and 2016, we treated 44 cases of TEVAR without type I a endoleaks with 0% mortality(most of the them was zone 2~3 TEVAR in this period) on the one hand, and the number of open surgery for thoracic aorta was 80 on the other...
April 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28424038/a-novel-method-for-the-treatment-of-bilateral-hypogastric-aneurysms-using-hybrid-polytetrafluoroethylene-graft
#16
Sam Tyagi, D Pineda, H Zheng, M Dougherty, K Calligaro, D Troutman
Open aortic aneurysm repair in the setting of bilateral hypogastric aneurysms is technically challenging. We present a novel technique for open surgical repair for bilateral hypogastric aneurysms using the Gore hybrid vascular graft (GVHG; W. L. Gore and Associates Inc, Flagstaff, Arizona). The GVHG is an expanded polytetrafluoroethylene graft with a nitinol stent at 1 end designed for hemodialysis access. The GVHG has been also been used for aortic debranching and treatment of occlusive disease. We describe the first report using GVHG to repair hypogastric aneurysms...
May 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28411221/an-extracellular-cell-attached-pullulanase-confers-branched-%C3%AE-glucan-utilization-in-human-gut-lactobacillus-acidophilus
#17
Marie S Møller, Yong Jun Goh, Kasper Bøwig Rasmussen, Wojciech Cypryk, Hasan Ufuk Celebioglu, Todd R Klaenhammer, Birte Svensson, Maher Abou Hachem
Of the few predicted extracellular glycan-active enzymes, glycoside hydrolase family 13 subfamily 14 (GH13_14) pullulanases are the most common in human gut lactobacilli. These enzymes share a unique modular organization, not observed in other bacteria, featuring a catalytic module, two starch binding modules, a domain of unknown function, and a C-terminal surface layer association protein (SLAP) domain. Here we explore the specificity of a representative of this group of pullulanases, LaPul13_14 and its role in branched α-glucans metabolism in the well characterized Lactobacillus acidophilus NCFM that is widely used as a probiotic...
April 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28408933/endovascular-stent-grafting-for-aortic-arch-aneurysm-in-aortoiliac-occlusive-disease-following-aortic-arch-debranching-and-aortobifemoral-reconstruction
#18
Didem Melis Oztas, Cagla Canbay, Yilmaz Onal, Metin Onur Beyaz, Omer Ali Sayin, Mehmet Barburoglu, Mehmet Buget, Mesut Yornuk, Aziz Ari, Murat Ugurlucan, Bulent Acunas, Ufuk Alpagut, Enver Dayioglu
Treatment of thoracic aortic aneurysms constitutes high mortality and morbidity rates despite improvements in surgery, anesthesia, and technology. Endovascular stent grafting may be an alternative therapy with lower risks when compared with conventional techniques. However, sometimes the branches of the aortic arch may require transport to the proximal segments prior to successful thoracic aortic endovascular stent grafting. Atherosclerosis is accounted among the etiology of both aneurysms and occlusive diseases that can coexist in the same patient...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28398537/intima-migration-from-the-iliac-artery-to-a-debranched-graft-after-thoracic-endovascular-aortic-repair
#19
Kazuki Kihara, Miwa Tashiro, Hideaki Nishimori, Kazumasa Orihashi
An 84-year-old woman underwent single-debranched thoracic endovascular aortic repair for aortic aneurysm. A few hours later, malperfusion of the left upper extremity occurred. Surgical exploration revealed a tubular-shaped intima packed in the debranched graft. As computed tomography showed localized dissection in the right external iliac artery probably due to access route injury, the intima roll was thought to have migrated from the iliac artery. This extremely rare case is described in detail with a discussion of the potential mechanism...
April 6, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28391477/microbial-xylanases-and-their-industrial-application-in-pulp-and-paper-biobleaching-a-review
#20
Abhishek Walia, Shiwani Guleria, Preeti Mehta, Anjali Chauhan, Jyoti Parkash
Xylanases are hydrolytic enzymes which cleave the β-1, 4 backbone of the complex plant cell wall polysaccharide xylan. Xylan is the major hemicellulosic constituent found in soft and hard food. It is the next most abundant renewable polysaccharide after cellulose. Xylanases and associated debranching enzymes produced by a variety of microorganisms including bacteria, actinomycetes, yeast and fungi bring hydrolysis of hemicelluloses. Despite thorough knowledge of microbial xylanolytic systems, further studies are required to achieve a complete understanding of the mechanism of xylan degradation by xylanases produced by microorganisms and their promising use in pulp biobleaching...
May 2017: 3 Biotech
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