Kevin M Mendez, Sofina Begum, Anshul Tiwari, Rinku Sharma, Qingwen Chen, Rachel S Kelly, Nicole Prince, Mengna Huang, Priyadarshini Kachroo, Su H Chu, Yulu Chen, Kathleen Lee-Sarwar, David I Broadhurst, Stacey N Reinke, Robert Gerszten, Clary Clish, Lydiana Avila, Juan C Celedón, Craig E Wheelock, Scott T Weiss, Michael McGeachie, Jessica A Lasky-Su
BACKGROUND: Lung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of the relationship between metabolomics and LFTs or their genomic determinants. METHODS: We utilized ordinal logistic regression to identify plasma metabolite principal components associated with four previously-published LFTs in children from the Childhood Asthma Management Program (CAMP) (n = 660)...
March 7, 2024: EBioMedicine