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https://www.readbyqxmd.com/read/28818266/microrna-93-elevation-after-myocardial-infarction-is-cardiac-protective
#1
Kai Li, Tao Lin, Lingdan Chen, Neng Wang
Coronary Artery Disease (CAD) is one of the most serious diseases that endangers human health worldwide, myocardial infarction (MI) is an acute form of CAD. Recent developments in MI therapies have resulted in significant reductions in mortality. However, subsequent chronic congestive heart failure and ventricle remodeling plagues an increasing number of MI patients. MicroRNAs (miR) have been reported to be involved in the process of cardiac remodeling, a recent study shows that miR-93 is elevated in the blood of CAD patients...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28814571/microrna-15b-deteriorates-hypoxia-reoxygenation-induced-cardiomyocyte-apoptosis-by-downregulating-bcl-2-and-mapk3
#2
Yaling Liu, Liqun Yang, Jiemin Yin, Diansan Su, Zhiying Pan, Peiying Li, Xiaodong Wang
To investigate the role of miRNA-15b in cardiomyocyte apoptosis after ischemia reperfusion injury in acute myocardial infarction (AMI), we conducted the AMI rat model by using left anterior descending ligation and performed hypoxia/reoxygenation experiments in H9c2 cells. MiRNA-15b was measured by quantitative reverse transcription PCR (qRT-PCR). Cardiomyocyte apoptosis was determined by terminal deoxynucleotide transferase dUTP nick end labeling staining. Synthesized miRNA-15b mimic and inhibitor were transfected into H9c2 cells by Lipofectamine regent...
August 16, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28811555/identification-of-novel-micrornas-in-the-sheep-heart-and-their-regulation-in-heart-failure
#3
Lee Lee Wong, Miriam T Rademaker, Eng Leng Saw, Kar Sheng Lew, Leigh J Ellmers, Christopher J Charles, Arthur Mark Richards, Peipei Wang
Study of microRNA (miRNAs) using sheep models is limited due to lack of miRNA information. We therefore investigated oar-miRNAs and their regulation in an ovine model of heart failure (HF). Left ventricular (LV) tissue was collected from normal (Cont), HF (LV pacing @ ~220bpm for 13-days) and HF-recovery sheep (HF-R, 26-days after pacing cessation). MiRNA expression was profiled using next-generation sequencing (NGS) and miRNA array, and validated by stem-loop qPCR. Detected sequences were mapped against the ovine genome (Oar v4...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811127/attenuation-of-sunitinib-induced-cardiotoxicity-through-the-a3-adenosine-receptor-activation
#4
Hardip Sandhu, Samantha Cooper, Afthab Hussain, Christopher Mee, Helen Maddock
Sunitinib is an anti-cancer tyrosine kinase inhibitor associated with severe cardiotoxic adverse effects. Using rat Langendorff heart model and human acute myeloid leukemia 60 (HL60) cell line we detected the involvement of protein kinase C (PKC) α during Sunitinib-induced cardiotoxicity and the effect of Sunitinib on cancer progression. The cardioprotective and anti-cancer properties of the A3 adenosine receptor agonist 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (IB-MECA) were investigated...
August 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28810055/impact-of-mir-26b-on-cardiomyocyte-differentiation-in-p19-cells-through-regulating-canonical-non-canonical-wnt-signalling
#5
Duo Wang, Chang Liu, Yumei Wang, Wenjing Wang, Kang Wang, Xiujuan Wu, Zhigang Li, Cuimei Zhao, Li Li, Luying Peng
BACKGROUND AND OBJECTIVES: The control of cardiomyocyte differentiation is tightly linked to microRNAs (miRNAs), which have been emerging as important players in heart development. However, the regulation mechanisms mediated by miRNAs in early heart development remains speculative. Here, we evaluated the impact of miR-26b during the progression of cardiomyocyte differentiation from the P19 cell line. MATERIALS AND METHODS: The overexpression of miR-26b in P19 cells was performed by transduction with lentivirus vector...
August 15, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28804599/circulating-exosome-microrna-associated-with-heart-failure-secondary-to-myxomatous-mitral-valve-disease-in-a-naturally-occurring-canine-model
#6
Vicky K Yang, Kerry A Loughran, Dawn M Meola, Christine M Juhr, Kristen E Thane, Airiel M Davis, Andrew M Hoffman
Myxomatous mitral valve disease (MMVD) is functionally and histologically identical to mitral valve prolapse (MVP) in humans. Currently, there are no medical treatments that can delay the progression of this valvular disease or associated cardiac remodelling. Therefore, there is a need to understand the molecular pathology associated with MMVD and MVP better, and thus identify potential therapeutic targets. Circulating exosomes contain small RNA, including miRNA, which reflect cell physiology and pathology...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28796841/single-cell-qpcr-reveals-that-additional-hand2-and-microrna-1-facilitate-the-early-reprogramming-progress-of-seven-factor-induced-human-myocytes
#7
Emre Bektik, Adrienne Dennis, Prateek Prasanna, Anant Madabhushi, Ji-Dong Fu
The direct reprogramming of cardiac fibroblasts into induced cardiomyocyte (CM)-like cells (iCMs) holds great promise in restoring heart function. We previously found that human fibroblasts could be reprogrammed toward CM-like cells by 7 reprogramming factors; however, iCM reprogramming in human fibroblasts is both more difficult and more time-intensive than that in mouse cells. In this study, we investigated if additional reprogramming factors could quantitatively and/or qualitatively improve 7-factor-mediated human iCM reprogramming by single-cell quantitative PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28792711/differential-expression-of-micrornas-in-calcific-aortic-stenosis
#8
Hai-Xia Xu, Yan Wang, Dong-Dong Zheng, Teng Wang, Min Pan, Jia-Hai Shi, Jian-Hua Zhu, Xiao-Fei Li
BACKGROUND: Calcific aortic stenosis (CAS) is the most common heart valve disorder. To explore the underlying mechanisms, we investigated whether key microRNAs in calcified aortic valves are differentially expressed compared to those in the non-calcified valves. METHODS: Calcified aortic valves from patients with aortic stenosis and non-calcified aortic valves (control) from patients with aortic insufficiency (n = 8 per group) were obtained during cardiac valve replacement surgery...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28789823/serum-exosomal-protein-profiling-for-the-non-invasive-detection-of-cardiac-allograft-rejection
#9
Peter J Kennel, Amit Saha, Dawn A Maldonado, Raymond Givens, Danielle L Brunjes, Estibaliz Castillero, Xiaokan Zhang, Ruiping Ji, Alexandre Yahi, Isaac George, Donna M Mancini, Antonius Koller, Barry Fine, Emmanuel Zorn, Paolo C Colombo, Nicholas Tatonetti, Emily I Chen, P Christian Schulze
BACKGROUND: Exosomes are cell-derived circulating vesicles that play an important role in cell-cell communication. Exosomes are actively assembled and carry messenger RNAs, microRNAs and proteins. The "gold standard" for cardiac allograft surveillance is endomyocardial biopsy (EMB), an invasive technique with a distinct complication profile. The development of novel, non-invasive methods for the early diagnosis of allograft rejection is warranted. We hypothesized that the exosomal proteome is altered in acute rejection, allowing for a distinction between non-rejection and rejection episodes...
July 19, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28777253/mir-30e-attenuates-isoproterenol-induced-cardiac-fibrosis-through-suppressing-snai1-tgf%C3%AE-signaling
#10
Zhang Wenqi, Chang Hong, Zhang Hexun, Zhang Lei
BACKGROUND: MicroRNAs (miRNAs) are a class of small RNA molecules that inhibit protein expression through either degradation of mRNA or interference with protein translation. Our previous work suggested an involvement of miR-30e in myocardial fibrosis; however, the exact role of miR-30e in the pathogenesis of cardiac fibrosis and the underlying mechanisms are not known. METHODS: Male Sprague Dawley rats were treated with isoproterenol to induce cardiac remodeling and fibrosis and treated with either miR-30e agomir (AG) or antagomir and respective controls...
August 4, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28775014/brain-heart-interaction-cardiac-complications-after-stroke
#11
REVIEW
Zhili Chen, Poornima Venkat, Don Seyfried, Michael Chopp, Tao Yan, Jieli Chen
Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, that is, the effects of cardiac injury on the brain and the effects of brain injury on the heart. This review article focuses on cardiac dysfunction in the setting of stroke such as ischemic stroke, brain hemorrhage, and subarachnoid hemorrhage. The majority of post-stroke deaths are attributed to neurological damage, and cardiovascular complications are the second leading cause of post-stroke mortality...
August 4, 2017: Circulation Research
https://www.readbyqxmd.com/read/28772218/suppression-of-microrna-142-5p-attenuates-hypoxia-induced-apoptosis-through-targeting-sirt7
#12
Liying Zhan, Shaoqing Lei, Wenlan Li, Yuan Zhang, Huaxin Wang, Yan Shi, Yulong Tian
Increasing study has suggested that microRNAs (miRNAs) are pivotal regulators in regulating hypoxia-induced injury. miR-142-5p has been suggested as a critical regulator for cellular survival. However, the role of miR-142-5p in regulating hypoxia-induced injury remains unknown. In this study, we aimed to investigate the mechanistic roles of miR-142-5p in regulating cell survival during hypoxia treatment using H9C2 cardiomyoblasts and primary cardiomyocytes. We showed that miR-142-5p expression level was significantly repressed by hypoxia treatment...
July 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28772031/local-microrna-133a-downregulation-is-associated-with-hypertrophy-in-the-dyssynchronous-heart
#13
Lars B van Middendorp, Marion Kuiper, Chantal Munts, Philippe Wouters, Jos G Maessen, Frans A van Nieuwenhoven, Frits W Prinzen
AIMS: Left bundle branch block (LBBB) creates considerable regional differences in mechanical load within the left ventricle (LV). We investigated expression of selected microRNAs (miRs) in relation to regional hypertrophy and fibrosis in LBBB hearts and their reversibility upon cardiac resynchronization therapy (CRT). METHODS AND RESULTS: Eighteen dogs were followed for 4 months after induction of LBBB, 10 of which received CRT after 2 months. Five additional dogs served as control...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28770953/microrna-200c-exacerbates-the-ischemia-reperfusion-injury-of-heart-through-targeting-the-glutaminase-gls-mediated-glutamine-metabolism
#14
F Liu, Y Li, G Liu
OBJECTIVE: Cardiac ischemia and reperfusion, the common pathophysiological processes during cardiovascular surgery, are followed by oxidative stresses during the restoration of blood flow to the tissue, known as ischemia/reperfusion (IR) injury. microRNAs (miRNAs) are a group of endogenous, short and noncoding RNAs that post-transcriptionally repress their target mRNA expressions. Currently, the roles of microRNAs in the IR are still under investigated. This study will investigate the roles and mechanisms of miRNAs in the ischemia/reperfusion injury of the heart...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770869/micrornas-in-muscle-wasting-and-cachexia-induced-by-heart-failure
#15
Yihua Bei, Junjie Xiao
No abstract text is available yet for this article.
September 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28770867/role-of-micrornas-in-wasting-in-heart-failure
#16
Stephan von Haehling, Nicole Ebner, Marcelo R Dos Santos, Jochen Springer, Stefan D Anker
No abstract text is available yet for this article.
September 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28765595/integration-of-mirna-and-mrna-expression-profiles-reveals-microrna-regulated-networks-during-muscle-wasting-in-cardiac-cachexia
#17
Leonardo N Moraes, Geysson J Fernandez, Ivan J Vechetti-Júnior, Paula P Freire, Rodrigo W A Souza, Rolando A R Villacis, Silvia R Rogatto, Patricia P Reis, Maeli Dal-Pai-Silva, Robson F Carvalho
Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Several of these deregulated genes are known or putative targets of the altered miRNAs, including miR-29a-3p, miR-29b-3p, miR-210-5p, miR-214, and miR-489...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762019/epicardial-adipose-tissue-as-a-metabolic-transducer-role-in-heart-failure-and-coronary-artery-disease
#18
REVIEW
Vaibhav B Patel, Saumya Shah, Subodh Verma, Gavin Y Oudit
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose tissue is identified as a complex endocrine organ, which by exerting a wide array of regulatory functions at the cellular, tissue and systemic levels can have profound effects on the cardiovascular system. Different terms including "epicardial," "pericardial," and "paracardial" have been used to describe adipose tissue deposits surrounding the heart...
July 31, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28760335/microrna-21-regulates-peroxisome-proliferator-activated-receptor-alpha-a-molecular-mechanism-of-cardiac-pathology-in-cardiorenal-syndrome-type-4
#19
Sandra Chuppa, Mingyu Liang, Pengyuan Liu, Yong Liu, Marc C Casati, Allen W Cowley, Leah Patullo, Alison J Kriegel
Cardiovascular events are the leading cause of death in patients with chronic kidney disease (CKD), although the pathological mechanisms are poorly understood. Here we longitudinally characterized left ventricle pathology in a 5/6 nephrectomy rat model of CKD and identify novel molecular mediators. Next-generation sequencing of left ventricle mRNA and microRNA (miRNA) was performed at physiologically distinct points in disease progression, identifying alterations in genes in numerous immune, lipid metabolism, and inflammatory pathways, as well as several miRNAs...
July 28, 2017: Kidney International
https://www.readbyqxmd.com/read/28754848/microrna-199a-acts-as-a-potential-suppressor-of-cardiomyocyte-autophagy-through-targeting-hspa5
#20
Liang Chen, Fei-Yu Wang, Zhen-Yu Zeng, Ling Cui, Jian Shen, Xiao-Wei Song, Pan Li, Xian-Xian Zhao, Yong-Wen Qin
Autophagy is an adaptive response to cardiomyocytes survival under stress conditions. MicroRNAs (miRNAs, miR) have been described to act as potent modulators of autophagy. To investigate whether and how miR-199a modulated autophagy in vitro, primary cardiomyocytes were treated under starvation to induce autophagy. Results showed that down-regulation of miR-199a was sufficient to activate cardiomyocytes autophagy. MiR-199a suppressed cardiomyocytes autophagy through direct inhibiting heat shock protein family A member 5 (Hspa5)...
July 10, 2017: Oncotarget
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