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https://www.readbyqxmd.com/read/28212530/transcriptome-analysis-reveals-non-identical-microrna-profiles-between-arterial-and-venous-plasma
#1
Wenjing Xu, Yuan Zhou, Guoheng Xu, Bin Geng, Qinghua Cui
Circulating microRNAs presented in venous plasma have been demonstrated as powerful biomarkers for the complex diseases like cancer. Nevertheless, those presented in arterial plasma remained largely unexplored. Here, using microarray technique, we compared microRNA expression profiles of the matched arterial and venous plasma samples from the same male rats. Though the microRNA profiles were largely similar, we identified 24 differentially expressed microRNAs, including 10 arterial highly expressed microRNAs and 14 venous highly expressed microRNAs...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28193507/identification-of-organ-tissue-types-and-skin-from-forensic-samples-by-microrna-expression-analysis
#2
Eva Sauer, Antje Extra, Philipp Cachée, Cornelius Courts
The identification of organ tissues in traces recovered from scenes and objects with regard to violent crimes involving serious injuries can be of considerable relevance in forensic investigations. Molecular genetic approaches are provably superior to histological and immunological assays in characterizing organ tissues, and micro-RNAs (miRNAs), due to their cell type specific expression patterns and stability against degradation, emerged as a promising molecular species for forensic analyses, with a range of tried and tested indicative markers...
February 5, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28188930/microrna-135a-regulates-sodium-calcium-exchanger-gene-expression-and-cardiac-electrical-activity
#3
Eric Duong, Jiening Xiao, Xiao Yan Qi, Stanley Nattel
BACKGROUND: Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of Torsades de Pointes (TdP) arrhythmias. MicroRNAs (miRNAs) are key regulators of gene-expression that contribute to cardiac remodeling. OBJECTIVE: To assess miRNA changes after complete atrioventricular block (CAVB) and identify novel candidates potentially involved in arrhythmogenic cardiac remodeling. METHODS: CAVB was induced in mice via His bundle ablation...
February 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28188250/mir30-galnt1-2-axis-mediated-glycosylation-contributes-to-the-increased-secretion-of-inactive-human-prohormone-for-brain-natriuretic-peptide-probnp-from-failing-hearts
#4
Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Aoi Fujishima, Shogo Oka, Takayoshi Tsutamoto, Hideyuki Kinoshita, Kazuhiro Nakao, Kosai Cho, Hideaki Inazumi, Hiroyuki Okamoto, Motohiro Nishida, Takao Kato, Hiroyuki Fukushima, Jun K Yamashita, Wino J Wijnen, Esther E Creemers, Kenji Kangawa, Naoto Minamino, Kazuwa Nakao, Takeshi Kimura
BACKGROUND: Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. The precise mechanisms governing the increase in proBNP remain unclear, however. METHODS AND RESULTS: We used our recently developed, highly sensitive human proBNP assay system to investigate the mechanisms underlying the increase in plasma proBNP levels...
February 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28185170/mechanisms-of-cardiomyocyte-proliferation-and-differentiation-in-development-and-regeneration
#5
REVIEW
Jessie Wettig Yester, Bernhard Kühn
PURPOSE OF REVIEW: Congenital heart disease is the most common birth defect and acquired heart disease is the leading cause of death in adults. Understanding the mechanisms that drive cardiomyocyte proliferation and differentiation has the potential to advance the understanding and potentially the treatment of different cardiac pathologies, ranging from myopathies and heart failure to myocardial infarction. This review focuses on studies aimed at elucidating signal transduction pathways and molecular mechanisms that promote proliferation, differentiation, and regeneration of differentiated heart muscle cells, cardiomyocytes...
February 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28183786/extracellular-rnas-are-associated-with-insulin-resistance-and-metabolic-phenotypes
#6
Ravi Shah, Venkatesh Murthy, Michael Pacold, Kirsty Danielson, Kahraman Tanriverdi, Martin G Larson, Kristina Hanspers, Alexander Pico, Eric Mick, Jared Reis, Sarah de Ferranti, Elizaveta Freinkman, Daniel Levy, Udo Hoffmann, Stavroula Osganian, Saumya Das, Jane E Freedman
OBJECTIVE: Insulin resistance (IR) is a hallmark of obesity and metabolic disease. Circulating extracellular RNAs (ex-RNAs), stable RNA molecules in plasma, may play a role in IR, though most studies on ex-RNAs in IR are small. We sought to characterize the relationship between ex-RNAs and metabolic phenotypes in a large community-based human cohort. RESEARCH DESIGN AND METHODS: We measured circulating plasma ex-RNAs in 2,317 participants without diabetes in the Framingham Heart Study (FHS) Offspring Cohort at cycle 8 and defined associations between ex-RNAs and IR (measured by circulating insulin level)...
February 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28178938/messenger-rna-and-microrna-transcriptomic-signatures-of-cardiometabolic-risk-factors
#7
David D McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J Munson, Martin G Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E Freedman, Daniel Levy
BACKGROUND: Cardiometabolic (CM) risk factors are heritable and cluster in individuals. We hypothesized that CM risk factors are associated with multiple shared and unique mRNA and microRNA (miRNA) signatures. We examined associations of mRNA and miRNA levels with 6 CM traits: body mass index, HDL-cholesterol and triglycerides, fasting glucose, and systolic and diastolic blood pressures through cross-sectional analysis of 2812 Framingham Heart Study who had whole blood collection for RNA isolation for mRNA and miRNA expression studies and who consented to genetic research...
February 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28177059/microrna-122-regulates-caspase-8-and-promotes-the-apoptosis-of-mouse-cardiomyocytes
#8
Z W Zhang, H Li, S S Chen, Y Li, Z Y Cui, J Ma
Cardiomyocyte apoptosis plays key roles in the pathogenesis of heart diseases such as myocardial infarction. MicroRNAs are important regulators of gene expression, which are also involved in the regulation of cardiomyocyte apoptosis. However, cardiomyocyte apoptosis regulated by microRNA (miR)-122 is largely unexplored. The aim of this study focused on the role of miR-122 in cardiomyocyte apoptosis. Cardiomyocytes were isolated from neonatal mice and primarily cultured. MiR-122 mimic and inhibitor were transfected to cardiomyocytes and verified by qRT-PCR...
February 6, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28169059/the-diagnostic-sensitivity-of-circulating-cardio-enriched-micrornas-is-increased-after-normalization-of-high-density-lipoprotein-levels
#9
Thrishila Parshu Ram, Ingrid Fomison-Nurse, Sophie Gandhi, Sean Coffey, Pankaj Saxena, Ivor Galvin, Richard Bunton, Michael J A Williams, Regis R Lamberts, Rajesh Katare
BACKGROUND: Emerging evidence suggests that microRNAs (miRs) could be a potential biomarker to identify early molecular alterations in the heart. HDL are the major carriers for miRs into the circulation. This study tested whether changes in the level of HDL could affect the diagnostic sensitivity of miRs. METHODS AND RESULTS: Peripheral blood samples were collected from 20 diabetic and 22 age and gender matched non-diabetic patients undergoing coronary artery bypass graft (CABG) surgery for ischemic heart disease (IHD)...
January 26, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28164128/roles-of-mir-17-92-cluster-in-cardiovascular-development-and-common-diseases
#10
REVIEW
Huanyu Gu, Zhuyuan Liu, Lei Zhou
MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to dozens of miRNAs can form into a miRNA cluster, and the miR-17-92 cluster is one of them. Although firstly described as an oncogenic miRNA cluster, the miR-17-92 cluster has also been found to play critical role in normal cardiac development and cardiovascular disease...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28160209/increased-expression-of-microrna-378a-5p-in-acute-ethanol-exposure-of-rat-cardiomyocytes
#11
Zhongkai Wang, Jingwen Song, Liang Zhang, Songqun Huang, Lizhi Bao, Feng Chen, Xianxian Zhao
Alcohol abuse is a risk factor for a distinct form of congestive heart failure, known as alcoholic cardiomyopathy (ACM). Here, we investigate how microRNAs may participate in the induction of cardiomyocyte apoptosis associated with ethanol exposure in vitro. Increasing the concentrations of ethanol to primary rat cardiomyocytes resulted in elevated apoptosis assessed by annexin V and propidium iodide staining, and reduced expression of an enzyme for alcohol detoxification aldehyde dehydrogenase 2 (ALDH2). These ethanol effects were accompanied by a substantial elevation of miR-378a-5p...
February 3, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28159509/human-pericardial-fluid-contains-exosomes-enriched-with-cardiovascular-expressed-micrornas-and-promotes-therapeutic-angiogenesis
#12
Cristina Beltrami, Marie Besnier, Saran Shantikumar, Andrew I U Shearn, Cha Rajakaruna, Abas Laftah, Fausto Sessa, Gaia Spinetti, Enrico Petretto, Gianni D Angelini, Costanza Emanueli
The pericardial fluid (PF) is contained in the pericardial sac surrounding the heart. MicroRNA (miRNA) exchange via exosomes (endogenous nanoparticles) contributes to cell-to-cell communication. We investigated the hypotheses that the PF is enriched with miRNAs secreted by the heart and that it mediates vascular responses through exosome exchange of miRNAs. The study was developed using leftover material from aortic valve surgery. We found that in comparison with peripheral plasma, the PF contains exosomes enriched with miRNAs co-expressed in patients' myocardium and vasculature...
February 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28149370/changes-of-standard-physiological-perceptual-markers-and-circulating-micrornas-in-response-to-tennis-match-play-a-case-report-of-two-elite-players
#13
Matthias Wilhelm Hoppe, Christian Baumgart, Thomas Hilberg, Jürgen Freiwald, Udo Frank Wehmeier
This study aimed to describe the acute changes of both standard physiological-perceptual markers and circulating microRNAs in response to tennis match-play in a detailed case report. Two elite male baseliners with comparable tennis experience were tested for anthropometric and fitness related variables and played 2 h of match-play on a red-clay court. The changes of standard physiological-perceptual markers including the heart rate, lactate concertation, creatine kinase activity, urea concentration and rating of perceived exertion as well as circulating microRNA-133a, -486 and -126 expression rates were examined at 10 different time-points (i...
June 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28138556/myocardial-micrornas-associated-with-reverse-remodeling-in-human-heart-failure
#14
Carmen C Sucharov, David P Kao, J David Port, Anis Karimpour-Fard, Robert A Quaife, Wayne Minobe, Karin Nunley, Brian D Lowes, Edward M Gilbert, Michael R Bristow
BACKGROUND: In dilated cardiomyopathies (DCMs) changes in expression of protein-coding genes are associated with reverse remodeling, and these changes can be regulated by microRNAs (miRs). We tested the general hypothesis that dynamic changes in myocardial miR expression are predictive of β-blocker-associated reverse remodeling. METHODS: Forty-three idiopathic DCM patients (mean left ventricular ejection fraction 0.24 ± 0.09) were treated with β-blockers. Serial ventriculography and endomyocardial biopsies were performed at baseline, and after 3 and 12 months of treatment...
January 26, 2017: JCI Insight
https://www.readbyqxmd.com/read/28130111/microrna-365-accelerates-cardiac-hypertrophy-by-inhibiting-autophagy-via-the-modulation-of-skp2-expression
#15
Haibo Wu, Yuncan Wang, Xuechao Wang, Ruyi Li, Deyun Yin
Evidence is emerging of a tight link between cardiomyocyte autophagy and cardiac hypertrophy (CH). Sustained exposure to stress leads CH to progress to heart failure. Several miRNAs have been described in heart failure, and miRNA-based therapeutic approaches are being pursued. Although microRNA-365 (miR-365) has been testified as a positive modulator of CH, the specific mechanism remains unclear. In the present study, we observed that miR-365 expression was up-regulated in hypertrophic cardiomyocytes both in vivo and in vitro, and was accompanied by dysregulation of autophagy...
January 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28127557/mir-222-in-cardiovascular-diseases-physiology-and-pathology
#16
REVIEW
Shengguang Ding, Haitao Huang, Yiming Xu, Hao Zhu, Chongjun Zhong
MicroRNAs (miRNAs and miRs) are endogenous 19-22 nucleotide, small noncoding RNAs with highly conservative and tissue specific expression. They can negatively modulate target gene expressions through decreasing transcription or posttranscriptional inducing mRNA decay. Increasing evidence suggests that deregulated miRNAs play an important role in the genesis of cardiovascular diseases. Additionally, circulating miRNAs can be biomarkers for cardiovascular diseases. MiR-222 has been reported to play important roles in a variety of physiological and pathological processes in the heart...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28125729/association-of-serum-mir-142-3p-and-mir-101-3p-levels-with-acute-cellular-rejection-after-heart-transplantation
#17
Ihdina Sukma Dewi, Zsuzsanna Hollander, Karen K Lam, Janet-Wilson McManus, Scott J Tebbutt, Raymond T Ng, Paul A Keown, Robert W McMaster, Bruce M McManus, Olof Gidlöf, Jenny Öhman
BACKGROUND: Identifying non-invasive and reliable blood-derived biomarkers for early detection of acute cellular rejection in heart transplant recipients is of great importance in clinical practice. MicroRNAs are small molecules found to be stable in serum and their expression patterns reflect both physiological and underlying pathological conditions in human. METHODS: We compared a group of heart transplant recipients with histologically-verified acute cellular rejection (ACR, n = 26) with a control group of heart transplant recipients without allograft rejection (NR, n = 37) by assessing the levels of a select set of microRNAs in serum specimens...
2017: PloS One
https://www.readbyqxmd.com/read/28123459/role-of-micrornas-in-cardiac-development-and-disease
#18
Jing Tian, Xinjiang An, Ling Niu
Heart disease-related deaths are the highest in most societies and congenital heart diseases account for approximately 40% of prenatal deaths and over 20% of mortality in the first few months after birth. Congenital heart disease affects approximately 1% of all newborns and is the causative factor for more deaths within the first year of life as compared to all other genetic defects. Advances in treatment approaches increased life expectancy and led to an expansion of adult population with clinical manifestation of congenital heart defects in up to 90% of the children born with congenital heart diseases...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123343/let-7a-is-an-antihypertrophic-regulator-in-the-heart-via-targeting-calmodulin
#19
Xin Zhou, Fei Sun, Shenjian Luo, Wei Zhao, Ti Yang, Guiye Zhang, Ming Gao, Renzhong Lu, You Shu, Wei Mu, Yanan Zhuang, Fengzhi Ding, Chaoqian Xu, Yanjie Lu
Background: MicroRNAs (miRNAs) have been emerged as important regulator in a multiple of cardiovascular disease, including arrhythmia, cardiac hypertrophy and fibrosis, and myocardial infarction. The aim of this study was to investigate whether miRNA let-7a has antihypertrophic effects in angiotensin II (AngII)-induced cardiac hypertrophy. Methods: Neonatal rat ventricular myocytes (NRVMs) were exposed to AngII for 36 h as a cellular model of hypertrophy; subcutaneous injection of AngII for 2 weeks was used to establish a mouse model of cardiac hypertrophy in vivo study...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28123342/microrna-135a-regulates-apoptosis-induced-by-hydrogen-peroxide-in-rat-cardiomyoblast-cells
#20
Ning Liu, Yong-Feng Shi, Hong-Ying Diao, Yang-Xue Li, Yan Cui, Xian-Jing Song, Xin Tian, Tian-Yi Li, Bin Liu
Oxidative stress and apoptosis are the most important pathologic features of ischemic heart disease. Recent research has indicated that microRNAs (miRs) play an essential role in apoptosis. However, whether miRs might regulate B cell lymphoma-2 (Bcl-2) protein in apoptosis during ischemic heart disease is still unclear. The aim of this study, therefore, was to confirm the regulation of microRNA-135a (miR-135a) in oxidative stress injuries induced by hydrogen peroxide (H2O2) in rat cardiomyoblast cells H9c2...
2017: International Journal of Biological Sciences
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