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https://www.readbyqxmd.com/read/28819801/botulinum-toxin-treatment-in-multiple-sclerosis-a-review
#1
REVIEW
Yasaman Safarpour, Tahereh Mousavi, Bahman Jabbari
Purpose of review The purpose of this review is to provide updated information on the role of botulinum neurotoxin (BoNT) therapy in multiple sclerosis (MS). This review aims to answer which symptoms of multiple sclerosis may be amenable to BoNT therapy. Recent findings We searched the literature on the efficacy of BoNTs for treatment of MS symptoms up to April 1st 2017 via the Yale University Library's search engine including but not limited to Pub Med and Ovis SP. The level of efficacy was defined according to the assessment's criteria set forth by the Subcommittee on Guideline Development of the American Academy of Neurology...
August 17, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28819483/-malignant-teratoma-about-a-case-and-a-review-of-the-literature
#2
Abdi Ahmed Bonahy, Houssam Sabbah, Ahmed Haiba Med Vadell, Nacer Eddine Med Baba
Dermoid cysts account for 10-20% of ovarian germ cell tumors. Malignant transformation within ovarian dermoid cyst has been reported in 1-2 per cent of the cases. The treatment remains controversial. In women of childbearing age and in the first stages of the disease unilateral annexectomy without adjuvant therapy is recommended. In menopausal women extensive surgery is sometimes performed, no matter what stage of the disease the person is experiencing. We report the case of a menopausal patient with malignant transformation within ovarian dermoid cyst who underwent surgery...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28818433/dose-ranging-design-and-analysis-methods-to-identify-the-minimum-effective-dose-med
#3
Yijie Zhou, Su Chen, Danielle Sullivan, Yihan Li, Ying Zhang, Wangang Xie, Hongtao Zhang, Yuanyuan Tang, Li Wang, Alan Hartford, Bo Yang
In dose ranging clinical trials, it is critical to investigate the dose-response profile and to identify a minimum effective dose (MED) to guide the dose selection for phase 3 confirmatory trials. Traditional dose ranging trials focus on pairwise comparisons between placebo and each investigational dose, while in recent years MCP-Mod (Multiple Comparison Procedures & Modeling) arose and gained popularity in the design and analysis of dose ranging trials. Comprehensive comparison between MCP-Mod and other methods have been made on continuous variables assuming a normal distribution...
August 14, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28818151/you-re-the-flight-surgeon
#4
(no author information available yet)
Hatcher DR. You're the flight surgeon: migraine aura without headaches. Aerosp Med Hum Perform. 2017; 88(9):887-891.
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818150/you-re-the-flight-surgeon
#5
(no author information available yet)
Casstevens EA. You're the flight surgeon: an unexpected twist. Aerosp Med Hum Perform. 2017; 88(9):884-887.
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818149/cerebellar-infarction-presenting-with-acute-vestibular-syndrome-in-two-u-s-air-force-pilots
#6
Roger R Hesselbrock
BACKGROUND: Cerebellar infarction is an uncommon but serious cause of isolated acute vestibular symptoms, particularly in young, healthy individuals, and can easily be overlooked. We present two cases of cerebellar infarction in U.S. Air Force pilots, one of which occurred during flight. CASE REPORTS: A 41-yr-old man developed acute vertigo, disequilibrium, nausea, and headache, with progressive slow symptomatic improvement, and presented to medical attention 4 d after symptom onset...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818148/cross-sectional-survey-of-physicians-on-providing-volunteer-care-for-in-flight-medical-events
#7
Eric Chatfield, William F Bond, Bradley McCay, Claude Thibeault, Paulo M Alves, Marc Squillante, Joshua Timpe, Courtney J Cook, Raymond E Bertino
BACKGROUND: Airline carriers have equipment, procedures, and protocols in place to handle in-flight medical events (IFMEs). Community physicians may be asked for aid during IFMEs. Cross-Sectional Survey of Physicians on Providing Volunteer Care for In-Flight Medical Events surveyed self-assessed awareness and knowledge, perceived barriers, and suggestions for improving responses to IFMEs. METHODS: We composed a survey regarding clinicians' self-assessed understanding of in-flight resources, procedures, flight environmental issues, and Good Samaritan protections...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818147/attention-deficit-hyperactivity-disorder-and-fatal-accidents-in-aviation-medicine
#8
Tanja Laukkala, Robert Bor, Bruce Budowle, Antti Sajantila, Pooshan Navathe, Markku Sainio, Alpo Vuorio
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with symptoms of inattention and/or hyperactivity-impulsivity that interfere with functioning and/or development. ADHD occurs in about 2.5% of adults. ADHD can be an excluding medical condition among pilots due to the risk of attentional degradation and therefore impact on flight safety. Diagnosis of ADHD is complex, which complicates aeromedical assessment. This study highlights fatal accident cases among pilots with ADHD and discusses protocols to detect its presence to help to assess its importance to flight safety...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818146/metabolic-syndrome-and-cardio-cerebrovascular-risk-disparities-between-pilots-and-aircraft-mechanics
#9
Myeong-Bo Kim, Hyun-Jin Kim, Soo-Hyeon Kim, Suk-Ho Lee, Se-Ho Lee, Won-Ju Park
INTRODUCTION: In the Republic of Korea Air Force, the health of pilots is strictly supervised, but there is comparatively not enough interest in aircraft mechanics' health. Among mechanics, who are heavily involved in military aircraft maintenance, the occurrence of sudden cardio-cerebrovascular diseases (CCVDs) is a possible risk factor during the maintenance process, which should be performed perfectly. METHODS: We performed health examinations on 2123 male aircraft pilots and 1271 aircraft mechanics over 30 yr of age and determined the prevalence of metabolic syndrome (MetS), an important risk factor for CCVDs...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818145/protective-effects-of-emotional-intelligence-and-proactive-coping-on-civil-pilots-mental-health
#10
Yaning Guo, Ming Ji, Xuqun You, Jie Huang
INTRODUCTION: Pilots' mental health is an issue of crucial importance that may endanger flight safety. As such, it is of profound significance to address the question of what characteristics are protective of mental health among pilots. The present study aimed to explore the indirect effects of emotional intelligence (EI) on depression and anxiety via proactive coping, and examine the moderating role of previous flight experience (PFE) in the conditional indirect effect of EI on depression through proactive coping...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818144/refining-selection-for-elite-troops-by-predicting-military-training-outcome
#11
Susan Vrijkotte, Romain Meeusen, Bart Roelands, Sabine Kubesch, Olivier Mairesse, Guy de Schutter, Nathalie Pattyn
INTRODUCTION: Paratrooper training courses are very demanding, leading to a high number of drop-outs, despite existing selection criteria. This study investigated physiological, neuropsychological, and subjective data of completers and drop-outs during paratrooper training to identify potential predictive indices. METHODS: Tested were 24 paratrooper soldiers before (t0), after 8 wk (t1), and at the end of a 12-wk training camp (t2). There were 11 soldiers who completed the course and 13 dropped out...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818143/locomotion-strategy-and-magnitude-of-ground-reaction-forces-during-treadmill-training-on-iss
#12
Elena Fomina, Alexandra Savinkina
INTRODUCTION: Creation of the cosmonaut in-flight physical training process is currently based on the leading role of support afferents in the development of hypogravity changes in the motor system. We assume that the strength of support afferents is related to the magnitude of the ground reaction forces (GRF). For this purpose it was necessary to compare the GRF magnitude on the Russian BD-2 treadmill for different locomotion types (walking and running), modes (active and passive), and subjects...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818142/psychophysiological-assessment-in-pilots-performing-challenging-simulated-and-real-flight-maneuvers
#13
Bernd Johannes, Stefanie Rothe, André Gens, Soeren Westphal, Katja Birkenfeld, Edwin Mulder, Jörn Rittweger, Carla Ledderhos
BACKGROUND: The objective assessment of psychophysiological arousal during challenging flight maneuvers is of great interest to aerospace medicine, but remains a challenging task. In the study presented here, a vector-methodological approach was used which integrates different psychophysiological variables, yielding an integral arousal index called the Psychophysiological Arousal Value (PAV). METHODS: The arousal levels of 15 male pilots were assessed during predetermined, well-defined flight maneuvers performed under simulated and real flight conditions...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818141/autonomic-cardiovascular-responses-to-orthostatic-stress-after-a-short-artificial-gravity-exposure
#14
Qingguang Zhang, Joyce M Evans, Michael B Stenger, Fritz B Moore, Charles F Knapp
BACKGROUND: Intermittent artificial gravity (AG) training over days and weeks has been shown to improve the human orthostatic tolerance limit (OTL) and improve cardiovascular regulation in response to orthostatic stress. Effects of a single AG exposure are currently unknown. METHODS: We tested cardiovascular responses to orthostatic stress in 16 hypovolemic subjects (9 men and 7 women), once following a single, short (∼90 min) bout of AG and once following a similar period of head-down bed rest (HDBR)...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818140/dynamic-cerebral-autoregulation-during-the-combination-of-mild-hypercapnia-and-cephalad-fluid-shift
#15
Takuya Kurazumi, Yojiro Ogawa, Ryo Yanagida, Hiroshi Morisaki, Ken-Ichi Iwasaki
BACKGROUND: Mild hypercapnia combined with a cephalad fluid shift [e.g., that occurring during spaceflight or laparoscopic surgery with head-down tilt (HDT)] might affect cerebral autoregulation. However, no reports have described the effects of the combination on dynamic cerebral autoregulation. Therefore, we tested the hypothesis that the combination of mild hypercapnia and a cephalad fluid shift would attenuate dynamic cerebral autoregulation. METHODS: There were 15 healthy male volunteers who were exposed to 4 10-min protocols in which they received air in the supine position (Placebo/Supine), 3% carbon dioxide (CO2) in the supine position (CO2/Supine), air with -10° HDT (Placebo/HDT) and 3% CO2 with -10° HDT (CO2/HDT)...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28818139/bed-rest-and-intermittent-centrifugation-effects-on-human-balance-and-neuromotor-reflexes
#16
William H Paloski, Millard F Reschke, Alan H Feiveson
INTRODUCTION: The effects of repeated centrifugation in association with head-down tilt (HDT) bed rest (BR) on the mediation of basic reflexes associated with the major postural muscles was investigated as a potential countermeasure for maintaining balance control and neuromotor reflex function. METHODS: There were 15 male volunteers who were exposed to 21 d of 6° HDT-BR. Eight were treated with daily 1-h artificial gravity (AG) exposures aboard a short radius centrifuge that provided 1-g footward loading at heart level...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28816526/echocardiographic-assessment-of-right-ventricle-dimensions-and-function-after-exposure-to-extreme-altitude-is-an-expedition-to-8000%C3%A2-m-hazardous-for-right-ventricular-function
#17
Marta Kurdziel, Jarosław Wasilewski, Karolina Gierszewska, Anna Kazik, Gracjan Pytel, Jacek Wacławski, Adam Krajewski, Anna Kurek, Lech Poloński, Mariusz Gąsior
Kurdziel, Marta, Jarosław Wasilewski, Karolina Gierszewska, Anna Kazik, Gracjan Pytel, Jacek Wacławski, Adam Krajewski, Anna Kurek, Lech Poloński, and Mariusz Gąsior. Echocardiographic assessment of right ventricle dimensions and function after exposure to extreme altitude: Is an expedition to 8000 m hazardous for right ventricular function? High Alt Med Biol 00:000-000, 2017.-Although the right ventricle (RV) is under great hypoxic stress at altitude, still little is known what happens to the RV after descent...
August 17, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28815643/early-intervention-with-non-ablative-fractional-laser-to-improve-cutaneous-scarring-a-randomized-controlled-trial-on-the-impact-of-intervention-time-and-fluence-levels
#18
Katrine E Karmisholt, Emily Wenande, Daniel Thaysen-Petersen, Peter A Philipsen, Uwe Paasch, Merete Haedersdal
BACKGROUND AND OBJECTIVES: Laser treatment in the early phases of wound healing may reduce scar formation. However, little is known on when in the early wound healing phases laser exposure most optimally should be provided and at which fluence levels. This study investigates the clinical effect of non-ablative-fractional-laser (NAFL) performed at three early time points at a range of fluence levels versus untreated control scars. MATERIALS AND METHODS: A randomized, controlled, intra-individual trial with erbium-glass 1,540 nm NAFL versus no laser treatment on sixteen subjects receiving 10 standardized full-thickness punch-biopsy wounds...
August 16, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28815459/a-roadmap-for-reducing-cardiac-device-infections-a-review-of-epidemiology-pathogenesis-and-actionable-risk-factors-to-guide-the-development-of-an-infection-prevention-program-for-the-electrophysiology-laboratory
#19
REVIEW
Westyn Branch-Elliman
PURPOSE OF REVIEW: Cardiovascular implantable electronic device (CIED) infections are highly morbid, common, and costly, and rates are increasing (Sohail et al. Arch Intern Med 171(20):1821-8 2011; Voigt et al. J Am Coll Cardiol 48(3):590-1 2006). Factors that contribute to the development of CIED infections include patient factors (comorbid conditions, self-care, microbiome), procedural details (repeat procedure, contamination during procedure, appropriate pre-procedural prep, and antimicrobial use), environmental and organizational factors (patient safety culture, facility barriers, such as lack of space to store essential supplies, quality of environmental cleaning), and microbial factors (type of organism, virulence of organism)...
August 16, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28814394/dynamics-of-intrapericardial-and-extrapericardial-fat-tissues-during-long-term-dietary-induced-moderate-weight-loss
#20
Gal Tsaban, Arik Wolak, Hila Avni-Hassid, Yftach Gepner, Ilan Shelef, Yaakov Henkin, Dan Schwarzfuchs, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Lilac Tene, Hila Zelicha, Anat Yaskolka-Meir, Oded Komy, Avital Bilitzky, Yoash Chassidim, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Dror Dicker, Assaf Rudich, Meir J Stampfer, Iris Shai
Background: In view of evidence linking pericardial fat accumulation with increased cardiovascular disease risk, strategies to reduce its burden are needed. Data comparing the effects of specific long-term dietary interventions on pericardial fat tissue mobilization are sparse.Objective: We sought to evaluate intrapericardial-fat (IPF) and extrapericardial-fat (EPF) changes during weight-loss interventions by different dietary regimens.Design: During 18 mo of a randomized controlled trial, we compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equal low-fat (LF) diet among randomly assigned participants with moderate abdominal obesity...
August 16, 2017: American Journal of Clinical Nutrition
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