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https://www.readbyqxmd.com/read/29776917/treatment-refractory-mania-with-psychosis-in-a-post-transplant-patient-on-tacrolimus-a-case-report
#1
Muaid Ithman, Kunal Malhotra, Meelie Bordoloi, Garima Singh
Bipolar affective disorder type I imparts significant morbidity and disease burden in the Population. It is characterized by occurrence of one or more manic episodes which may be preceded or followed by a depressive or hypomanic phase. About half of these manic episodes are characterized by the presence of psychotic features [1]. The condition is further complicated when patient has multiple comorbid conditions. We report here a case of a 66 year old Caucasian female, previously diagnosed with Bipolar disorder who developed treatment refractory mania with psychotic feature after being on Tacrolimus (an immunosuppressive agent) after kidney transplantation...
May 18, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29766209/is-cannabis-a-risk-factor-for-suicide-attempts-in-men-and-women-with-psychotic-illness
#2
A Waterreus, P Di Prinzio, J C Badcock, M Martin-Iverson, A Jablensky, V A Morgan
OBJECTIVE: To investigate whether recent cannabis use by men and women with psychotic disorders was associated with increased risk of suicide attempt, and to determine associated factors, stratified by sex. METHODS: Data from 1065 men and 725 women interviewed in the Australian national survey of psychosis were analysed to model separately, for each sex, the impact of daily, casual or no past-year cannabis use and other risk factors including age, on a past-year suicide attempt...
May 16, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29755581/gender-differences-and-risk-factors-for-smoking-among-patients-with-various-psychiatric-disorders-in-saudi-arabia-a-cross-sectional-study
#3
Fahad D Alosaimi, Mohammed Abalhassan, Bandar Alhaddad, Ebtihaj O Fallata, Abdulhadi Alhabbad, Rabab Alshenqiti, Mohammed Z Alassiry
Background: The higher prevalence of smoking among psychiatric patients is well established. However, gender-specific associations have rarely been the focus of studies among patients with various psychiatric disorders. The aim of this study was to estimate the gender-specific prevalence of current smoking by psychiatric patients and its association with various psychiatric disorders and the use of psychotropic medications. Methods: A cross-sectional observational study was performed between July 2012 and June 2014...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29754115/delusional-misidentifications-in-a-procrustean-bed
#4
EDITORIAL
G N Christodoulou, M Margariti, N Christodoulou
The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally fused functions of perception and recognition. The classical sub-types are: the syndromes of Capgras, Fregoli,Intermetamorphosis (mentioned in 3) and Subjective doubles. These syndromes occur in a clear sensorium and shouldbe differentiated from the banal transient misidentifications occurring in confusional states and in mania and from thenon-delusional misidentifications (e...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29742940/the-role-of-oxidative-stress-in-anxiety-disorder-cause-or-consequence
#5
Alessandra das Graças Fedoce, Frederico Ferreira, Robert G Bota, Vicent Bonet-Costa, Patrick Y Sun, Kelvin J A Davies
Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates that oxidative stress may be a major component of anxiety pathology, whether oxidative stress is the cause or consequence remains elusive. Studies conducted over the past few years suggest that anxiety disorders may be characterized by lowered antioxidant defenses and increased oxidative damage to proteins, lipids and nucleic acids...
May 9, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29741616/a-systematic-review-of-genome-wide-research-on-psychotic-experiences-and-negative-symptom-traits-new-revelations-and-implications-for-psychiatry
#6
Angelica Ronald, Oliver Pain
We present a systematic review of genome-wide research on psychotic experience and negative symptom traits (PENS) in the community. We integrate these new findings, most of which have emerged over the last four years, with more established behaviour genetic and epidemiological research. The review includes the first genome-wide association studies of PENS, including a recent meta-analysis, and the first SNP heritability estimates. Sample sizes of < 10,000 participants mean that no genome-wide significant variants have yet been replicated...
May 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29739135/unipolar-mania-a-particular-aspect-of-bipolar-disorder-in-tunisia
#7
Badii Amamou, Wafa Chebbi, Myriam Allegue, Ahmed Mhalla, Ferid Zaafrane, Lotfi Gaha
Objective: Unipolar mania is a clinical reality in our daily practice. Many authors suggested that bipolar patients can have only manic episodes without depressions. These findings lead us to explore more this particularity. Methods: We conduct a retrospective, descriptive and comparative study including 173 patients, followed for bipolar disorder type I, according to the Diagnostic and Statistical Manual of Mental Disorders fifth edition criteria, during the period between January 2008 and December 2015...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29736129/analysis-of-misdiagnosis-of-bipolar-disorder-in-an-outpatient-setting
#8
Hui Shen, Li Zhang, Chuchen Xu, Jinling Zhu, Meijuan Chen, Yiru Fang
Background: Bipolar disorder is a mental illness with a high misdiagnosis rate and commonly misdiagnosed as other mental disorders including depression, schizophrenia, anxiety disorders, obsessive-compulsive disorders, and personality disorders, resulting in the mistreatment of clinical symptoms and increasing of recurrent episodes. Aims: To understand the reasons for misdiagnosis of bipolar disorder in an outpatient setting in order to help clinicians more clearly identify the disease and avoid diagnostic errors...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29736062/dropout-rates-and-factors-associated-with-dropout-from-treatment-among-elderly-patients-attending-the-outpatient-services-of-a-tertiary-care-hospital
#9
Sandeep Grover, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
Aim: This study aimed to evaluate the "dropout" rates from treatment and associated factors among elderly patients attending a tertiary care psychiatry outpatient facility. Materials and Methods: Data of 1422 patients aged ≥60 years, attending the walk-in clinic were evaluated. Results: Out of 1422 patients, 406 (28.55%) belonged to the "dropout" group. In the "dropout" group, the age of patients was significantly higher than the followed-up group, and a higher proportion of patients were >70 years old...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29731635/antidopaminergic-medication-in-healthy-subjects-provokes-subjective-and-objective-mental-impairments-tightly-correlated-with-perturbation-of-biogenic-monoamine-metabolism-and-prolactin-secretion
#10
Tanja Veselinović, Ingo Vernaleken, Paul Cumming, Uwe Henning, Lina Winkler, Peter Kaleta, Michael Paulzen, Christian Luckhaus, Gerhard Gründer
Objectives: Off-label prescription of antipsychotics to patients without psychotic symptoms has become a routine matter for many psychiatrists and also some general practitioners. Nonetheless, little is known about the possibly detrimental effects of antidopaminergic medications on general psychopathology, subjective mental state, or a possible association with physiological parameters in nonpsychotic individuals. Methods: In this randomized, single-blinded study, groups of healthy volunteers (n=18) received low doses of reserpine, aripiprazole, haloperidol, or placebo on 7 successive days...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29731633/impact-of-time-of-initiation-of-once-monthly-paliperidone-palmitate-in-hospitalized-asian-patients-with-acute-exacerbation-of-schizophrenia-a-post-hoc-analysis-from-the-prevail-study
#11
Huafang Li, Yan Li, Yu Feng, Jianmin Zhuo, Ibrahim Turkoz, Maju Mathews, Wilson Tan
Purpose: To evaluate the differences in efficacy and safety outcomes in acute exacerbating schizophrenia patients between 2 subgroups (≤1 week and >1 week), differing in time interval from hospitalization to time of initiation of once-monthly paliperidone palmitate. Patients and methods: PREVAIL was a multicenter, single-arm, open-label, prospective Phase IV study in hospitalized Asian patients (either sex, aged 18-65 years) diagnosed with schizophrenia ( Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition)...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29729448/quality-of-life-and-neuropsychiatric-disorders-in-patients-with-graves-orbitopathy-current-concepts
#12
REVIEW
Alice Bruscolini, Marta Sacchetti, Maurizio La Cava, Marcella Nebbioso, Angela Iannitelli, Adele Quartini, Alessandro Lambiase, Massimo Ralli, Armando de Virgilio, Antonio Greco
Graves' disease (GD) is an autoimmune chronic thyroiditis frequently associated with development of Graves' orbitopathy (GO) characterized by proptosis, strabismus, impairment of visual function, ocular surface inflammation and dry eye. As consequence, patients with GO experience impairment of quality of life and social function and could develop a neurobehavioral syndrome, ranging from anxious to depressive or psychotic disorders. To date, the pathogenic mechanism underlying neuropsychiatric disorders in patients with GD has not been clearly understood...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29727763/zinc-in-schizophrenia-a-meta-analysis
#13
Peter Joe, Matthew Petrilli, Dolores Malaspina, Judith Weissman
OBJECTIVE: The role of zinc homeostasis in various psychopathologies is an emerging area of interest. Zinc is strongly implicated in depressive disorders but is inadequately studied in schizophrenia, despite growing evidence of abnormal zinc transporters associated with schizophrenia. A meta-analysis of serum zinc concentrations in persons with schizophrenia was conducted to address this gap. METHOD: PubMed and Embase were searched for all articles published through February 2018 that reported serum zinc concentrations in individuals with schizophrenia and in comparison subjects...
April 27, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29721726/association-between-serum-lipid-levels-osteoprotegerin-and-depressive-symptomatology-in-psychotic-disorders
#14
Sherif M Gohar, Ingrid Dieset, Nils Eiel Steen, Ragni H Mørch, Trude S Iversen, Vidar M Steen, Ole A Andreassen, Ingrid Melle
Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study...
May 2, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29713175/electroconvulsive-therapy-in-77-year-old-patient-with-pacemaker-a-case-report
#15
Tomasz Mędrala, Anna Pycińska, Bartłomiej Pyciński, Wojciech Merk, Krzysztof Kucia
The treatment of a 77-year-old patient suffering from severe psychotic depression with a cardiac pacemaker is described. Because of treatment-resistant depression, electroconvulsive therapy (ECT) was introduced. In the course of ECT, there was a great improvement in his mental state without any cardiac complications. This case may be evidence for the safety and effectiveness of ECT in the elderly, even with cardiac comorbidities. Some recommendations for ECT in patients with pacemakers are discussed.
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29705022/comorbid-thyroid-disease-in-patients-with-major-depressive-disorder-results-from-the-european-group-for-the-study-of-resistant-depression-gsrd
#16
Gernot Fugger, Markus Dold, Lucie Bartova, Alexander Kautzky, Daniel Souery, Julien Mendlewicz, Alessandro Serretti, Joseph Zohar, Stuart Montgomery, Richard Frey, Siegfried Kasper
This multicenter study of the European Group for the Study of Resistant Depression (GSRD) aimed to explore the association between major depressive disorder (MDD) and comorbid thyroid disease. A total number of 1410 patients` characteristics in terms of demographic and clinical information were compared between MDD subjects with and without concurrent thyroid disease using descriptive statistics, analyses of covariance (ANCOVA) and binary logistic regression analyses. We determined a point prevalence rate for comorbid hypothyroidism of 13...
April 25, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29704411/are-suicide-risk-factors-gender-specific
#17
Joanna Maria Pawlak, Izabela Miechowicz, Monika Dmitrzak-Węglarz, Aleksandra Szczepankiewicz, Dorota Zaremba, Paweł Kapelski, Aleksandra Rajewska-Rager, Piotr Czerski, Maria Skibińska, Joanna Hauser
OBJECTIVES: Suicide is an important clinical problem in psychiatric patients. The highest risk of suicide attempts is noted in affective disorders. In this study we tested 20 factors described in the literature (sociodemographic and clinical factors as well as family burden) in association with suicidal behavior and we analyzed whether the significance of those factors differs between males and females. METHODS: In the study we included patients with major depressive disorder (MDD; n = 249) and bipolar affective disorder (BP; n = 582)...
February 28, 2018: Psychiatria Polska
https://www.readbyqxmd.com/read/29702303/the-moderating-role-of-cognitive-biases-on-the-relationship-between-negative-affective-states-and-psychotic-like-experiences-in-non-clinical-adults
#18
Katarzyna Prochwicz, Joanna Kłosowska
Negative emotions and cognitive biases are important factors underlying psychotic symptoms and psychotic-like experiences (PLEs); however, it is not clear whether these factors interact when they influence psychotic phenomena. The aim of our study was to investigate whether psychosis-related cognitive biases moderate the relationship between negative affective states, i.e. anxiety and depression, and psychotic-like experiences. The study sample contains 251 participants who have never been diagnosed with psychiatric disorders...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29699012/-mental-health-problems-among-female-staff-in-a-provincial-maternal-and-child-health-hospital-an-investigation-of-647-individuals
#19
W J He, J H Xia, X Lv, L M Li
Objective: To investigate the current status of depression and anxiety among female staff in a maternal and child health hospital, and to provide a basis for developing related prevention and intervention measures and promoting the mental health of female staff. Methods: The female staff from a provincial maternal and child health hospital completed a psycho-health questionnaire survey on Internet from June to October, 2016. The questionnaires used in the survey consisted of Patient Health Questionnaire (PHQ-9) , Generalized Anxiety Disorder Scale (GAD-7) , and Symptom Checklist-90 (SCL-90) ...
February 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29692285/metacognitive-reflection-and-insight-therapy-merit-for-patients-with-schizophrenia
#20
S de Jong, R J M van Donkersgoed, M E Timmerman, M Aan Het Rot, L Wunderink, J Arends, M van Der Gaag, A Aleman, P H Lysaker, G H M Pijnenborg
BACKGROUND: Impaired metacognition is associated with difficulties in the daily functioning of people with psychosis. Metacognition can be divided into four domains: Self-Reflection, Understanding the Other's Mind, Decentration, and Mastery. This study investigated whether Metacognitive Reflection and Insight Therapy (MERIT) can be used to improve metacognition. METHODS: This study is a randomized controlled trial. Patients in the active condition (n = 35) received forty MERIT sessions, the control group (n = 35) received treatment as usual...
April 25, 2018: Psychological Medicine
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