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https://www.readbyqxmd.com/read/28547702/emerging-treatments-in-eating-disorders
#1
REVIEW
Michael Lutter
Eating disorders (EDs), including anorexia nervosa, bulimia nervosa, and binge-eating disorder, constitute a class of common and deadly psychiatric disorders. While numerous studies in humans highlight the important role of neurobiological alterations in the development of ED-related behaviors, the precise neural substrate that mediates this risk is unknown. Historically, pharmacological interventions have played a limited role in the treatment of eating disorders, typically providing symptomatic relief of comorbid psychiatric issues, like depression and anxiety, in support of the standard nutritional and psychological treatments...
May 25, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28545572/intensive-case-management-for-addiction-to-promote-engagement-with-care-of-people-with-severe-mental-and-substance-use-disorders-an-observational-study
#2
Stéphane Morandi, Benedetta Silva, Philippe Golay, Charles Bonsack
BACKGROUND: Co-occurring severe mental and substance use disorders are associated with physical, psychological and social complications such as homelessness and unemployment. People with severe mental and substance use disorders are difficult to engage with care. The lack of treatment worsens their health and social conditions and increases treatment costs, as emergency department visits arise. Case management has proved to be effective in promoting engagement with care of people with severe mental and substance use disorders...
May 25, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28538629/outcomes-following-traumatic-injury-in-patients-with-preexisting-psychiatric-illness
#3
Erika Falsgraf, Kenji Inaba, Amory de Roulet, Megan Johnson, Elizabeth Benjamin, Lydia Lam, Kazuhide Matsushima, Aaron Strumwasser, Demetrios Demetriades
BACKGROUND: Patients with psychiatric illness have been shown to experience higher rates of traumatic injury. Injury patterns, treatment decisions, and outcomes have not been well characterized in patients with psychiatric illness after injury, in particular those who undergo acute surgical intervention. The purpose of this analysis was to determine mortality, complications, and surgical intervention rates in patients with psychiatric illness following traumatic injury. METHODS: This is a retrospective study of trauma patients ≥18 years old admitted to LAC+USC Medical Center between January 2008 and March 2015...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28535284/cumulative-effects-of-neighborhood-social-adversity-and-personal-crime-victimization-on-adolescent-psychotic-experiences
#4
Joanne Newbury, Louise Arseneault, Avshalom Caspi, Terrie E Moffitt, Candice L Odgers, Helen L Fisher
BACKGROUND: Little is known about the impact of urbanicity, adverse neighborhood conditions and violent crime victimization on the emergence of adolescent psychotic experiences. METHODS: Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally-representative cohort of 2232 British twins who were interviewed about adolescent psychotic experiences at age 18. Urbanicity, neighborhood characteristics, and personal victimization by violent crime were measured during childhood and adolescence via geocoded census data, surveys of over 5000 immediate neighbors of the E-Risk participants, and interviews with participants themselves...
May 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28531821/examining-the-physical-health-and-lifestyle-of-young-people-at-ultra-high-risk-for-psychosis-a-qualitative-study-involving-service-users-parents-and-clinicians
#5
Rebekah Carney, Jack Cotter, Tim Bradshaw, Alison R Yung
Emerging evidence suggests young people at ultra-high risk for psychosis (UHR) are also at-risk for poor physical health, and display high rates of modifiable cardiometabolic risk factors. However, before we can develop effective interventions there is a need to understand factors affecting lifestyle choices in the UHR group. We conducted semi-structured qualitative interviews with 20 UHR individuals (50% male; mean age 21.7), 5 parents (4 mothers, 1 father), and 6 clinicians from early intervention services in the Northwest of England to identify barriers and facilitators to living a healthy lifestyle, including achieving regular exercise, eating well and refraining from excessive substance use...
May 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28530343/-sexuality-in-psychiatric-hospitalization-reality-versus-policy
#6
Anat Shalev, Gabriel Weil, Ludmila Rubinstein
Psychiatric hospitalization might be a necessity for certain groups of patients with mental illness, involving acute symptoms and substantial disability which do not allow independent living in the community. In such situations, it is crucial to enable inpatients to enjoy the best possible quality of life, including the right for sexual autonomy as a basic human right. Satisfying sexual life is part of meaningful life and plays an important role in personal and social recovery. On the other hand, sexual relations in psychiatric wards raise many dilemmas, including the need to protect inpatients from sexual abuse and victimization, particularly when mental illness involves judgment deficits and decreased ability to express autonomous will...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28528986/how-family-members-of-mentally-ill-offenders-experience-the-internment-measure-and-forensic-psychiatric-treatment-in-belgium-a-qualitative-study
#7
Sara Rowaert, Stijn Vandevelde, Gilbert Lemmens, Kurt Audenaert
Mentally ill offenders in Belgium can be subjected to mandated care under an "internment measure" if they are viewed as a danger to society. This study investigated how family members of mentally ill offenders experience this internment measure and view the (forensic) psychiatric treatment of their relative. Semi-structured interviews were conducted with 24 relatives and analysed using Nvivo 11. Six different themes emerged: (1) the criminal offence and the internment measure as an additional stigma, (2) ambivalent feelings towards the judicial system, (3) prison is not the right place to be, (4) mental health support as an answer to problems, (5) fight a losing battle, and (6) while there is life there is hope...
May 18, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28526631/mating-strategies-and-sexual-functioning-in-personality-disorders-a%C3%A2-comprehensive-review-of-literature
#8
REVIEW
Alberto Collazzoni, Giacomo Ciocca, Erika Limoncin, Carmela Marucci, Daniele Mollaioli, Stefania Di Sante, Giorgio Di Lorenzo, Cinzia Niolu, Alberto Siracusano, Mario Maggi, Giovanni Castellini, Alessandro Rossi, Emmanuele A Jannini
INTRODUCTION: Personality disorders impair several aspects of intrapsychic and interpersonal life. In particular, mating strategies and sexual functioning could manifest in different and/or dysfunctional ways in people with personality disorders. AIM: To describe, through a comprehensive review of the literature, the mating strategies and sexual functioning in patients with personality disorders. METHODS: We listed and discussed the principal studies on the relation between mating strategies and sexual functioning in personality disorders...
May 16, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28524378/psychometric-characteristics-of-the-mental-health-crisis-assessment-scale-in-youth-with-autism-spectrum-disorder
#9
Luther G Kalb, Louis P Hagopian, Alden L Gross, Roma A Vasa
BACKGROUND: Youth with autism spectrum disorder (ASD) exhibit high rates of psychopathology. These symptoms can pose a risk of injury to self or others when the child is in crisis. Despite this danger, there are no instruments available to identify those with ASD who are at risk or actively in crisis. This study examined the psychometric properties of the Mental Health Crisis Assessment Scale (MCAS), a 28 item parent report measure. METHODS: The MCAS was administered to the parents of 606 children and young adults (aged 3-25 years, M age = 13 years, SD = 5 years) enrolled in the Interactive Autism Network, an online registry of families raising a child with ASD...
May 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28523978/closed-loop-neuromodulation-systems-next-generation-treatments-for-psychiatric-illness
#10
Meng-Chen Lo, Alik S Widge
Despite deep brain stimulation's positive early results in psychiatric disorders, well-designed clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit is closed-loop therapy: stimulation that is automatically adjusted by a device or algorithm in response to changes in the patient's electrical brain activity. These interventions may provide more precise and patient-specific treatments. This article first introduces the available closed-loop neuromodulation platforms, which have shown clinical efficacy in epilepsy and strong early results in movement disorders...
April 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/28522792/transgenic-autoinhibition-of-p21-activated-kinase-exacerbates-synaptic-impairments-and-fronto-dependent-behavioral-deficits-in-an-animal-model-of-alzheimer-s-disease
#11
Cyril Bories, Dany Arsenault, Myriam Lemire, Cyntia Tremblay, Yves De Koninck, Frédéric Calon
Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expression, particularly with symptoms related to frontal cortex dysfunction. To investigate the role of PAK combined with Aβ and tau pathologies (3xTg-AD mice) in the frontal cortex, we generated a transgenic model of AD with a deficit in PAK activity (3xTg-AD-dnPAK mice)...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28521251/the-protective-effect-of-character-maturity-in-child-aggressive-antisocial-behavior
#12
Nóra Kerekes, Örjan Falk, Sven Brändström, Henrik Anckarsäter, Maria Råstam, Björn Hofvander
BACKGROUND: Childhood aggressive antisocial behavior (CD) is one of the strongest predictors of mental health problems and criminal behavior in adulthood. The aims of this study were to describe personality profiles in children with CD, and to determine the strength of association between defined neurodevelopmental symptoms, dimensions of character maturity and CD. METHODS: A sample of 1886 children with a close to equal distribution of age (9 or 12) and gender, enriched for neurodevelopmental and psychiatric problems were selected from the nationwide Child and Adolescent Twin Study in Sweden...
April 29, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28520662/anxiety-disorders-in-adults-with-childhood-traumatic-brain-injury-evidence-of-difficulties-more-than-10-years-postinjury
#13
Michelle Albicini, Audrey McKinlay
OBJECTIVE: To explore long-term psychiatric outcomes in individuals with a history of childhood traumatic brain injury (TBI) or orthopedic injury (OI). SETTING: Hospital emergency department, medical admission records and outpatient settings. PARTICIPANTS: There were 95 males (M = 22.78 years, SD = 3.44 years) and 74 females (M = 22.27 years, SD = 3.09 years), 65 with mild TBI (M = 23.25 years, SD = 3.58 years), 61 with moderate-severe TBI (M = 22...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520584/eating-disorders-and-bone-metabolism-in-women
#14
Lauren Robinson, Nadia Micali, Madhusmita Misra
PURPOSE OF REVIEW: Eating Disorders are psychiatric disorders associated with a high risk for low bone mineral density (BMD) and fractures. Low BMD is a consequence of undernutrition, changes in body composition, and hormonal alterations. This review summarizes recent findings regarding novel strategies for assessing bone outcomes in patients with eating disorders, factors contributing to altered bone metabolism, and possible therapeutic strategies. RECENT FINDINGS: Emerging research in this field suggests that not only anorexia nervosa, but also bulimia nervosa results in lower BMD compared to controls...
May 16, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28517950/gender-differences-in-service-utilization-among-operations-enduring-freedom-iraqi-freedom-and-new-dawn-veterans-affairs-patients-with-severe-mental-illness-and-substance-use-disorders
#15
Janelle M Painter, Emily Brignone, Amanda K Gilmore, Keren Lehavot, Jamison Fargo, Ying Suo, Tracy Simpson, Marjorie E Carter, Rebecca K Blais, Adi V Gundlapalli
Severe mental illness (SMI) and substance use disorders (SUD) are among the more chronic and costly mental health conditions treated in the Department of Veterans Affairs (VA). Service use patterns of returning veterans with SMI and SUD have received little attention. We examined gender differences in the utilization of VA services among a national sample of Operations Enduring Freedom, Iraqi Freedom, and New Dawn (OEF/OIF/OND) VA patients with SMI, SUD, and their comorbidity (SMI/SUD) in their first year of established VA care (N = 24,166)...
May 18, 2017: Psychological Services
https://www.readbyqxmd.com/read/28517911/is-there-a-potential-of-misuse-for-magnolia-officinalis-compounds-metabolites
#16
Fabrizio Schifano, Valentina Guarino, Duccio G Papanti, Jacopo Baccarin, Laura Orsolini, John M Corkery
OBJECTIVE: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. METHODS: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. RESULTS: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28511773/psychiatric-patient-length-of-stay-in-the-emergency-department-following-closure-of-a-public-psychiatric-hospital
#17
Ryan K Misek, Ashley D Magda, Samantha Margaritis, Robert Long, Erik Frost
BACKGROUND: Psychiatric patient boarding in the emergency department (ED) is a ubiquitous problem associated with increased morbidity and mortality. OBJECTIVE: We evaluate the effect of closing a public psychiatric facility in a major metropolitan area on the ED length of stay (LOS) of psychiatric patients. METHODS: This was a retrospective chart review at two metropolitan EDs of all patients assessed to require inpatient psychiatric hospitalization...
May 13, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28502879/genetic-deletion-of-p-glycoprotein-alters-stress-responsivity-and-increases-depression-like-behavior-social-withdrawal-and-microglial-activation-in-the-hippocampus-of-female-mice
#18
Natalia I Brzozowska, Kristie L Smith, Cilla Zhou, Peter M Waters, Ligia Menezes Cavalcante, Sarah V Abelev, Michael Kuligowski, David J Clarke, Stephanie M Todd, Jonathon C Arnold
P-glycoprotein (P-gp) is an ABC transporter expressed at the blood brain barrier and regulates the brain uptake of various xenobiotics and endogenous mediators including glucocorticoid hormones which are critically important to the stress response. Moreover, P-gp is expressed on microglia, the brain's immune cells, which are activated by stressors and have an emerging role in psychiatric disorders. We therefore hypothesised that germline P-gp deletion in mice might alter the behavioral and microglial response to stressors...
May 10, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28502246/time-in-assertive-community-treatment-a-statewide-quality-improvement-initiative-to-reduce-length-of-participation
#19
Steven Huz, Helle Thorning, Candace N White, Lin Fang, Bikki Tran Smith, Marleen Radigan, Lisa B Dixon
The investigators describe a New York State initiative to increase flow through assertive community treatment (ACT) while encouraging transition to less intensive services. This initiative began as ACT approached full capacity and as evidence emerged that participants can sustain recovery post-ACT. Comparison of performance indicators over time showed that time in ACT decreased, turnover rate increased, and the percentage of ACT participants who met treatment objectives rose. Also, post-ACT rates of ambulatory behavioral health follow-up increased while rates of psychiatric inpatient hospitalization decreased...
May 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28497380/from-gene-to-behavior-l-type-calcium-channel-mechanisms-underlying-neuropsychiatric-symptoms
#20
REVIEW
Zeeba D Kabir, Arlene Martínez-Rivera, Anjali M Rajadhyaksha
The L-type calcium channels (LTCCs) Cav1.2 and Cav1.3, encoded by the CACNA1C and CACNA1D genes, respectively, are important regulators of calcium influx into cells and are critical for normal brain development and plasticity. In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder...
May 11, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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