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https://www.readbyqxmd.com/read/29341228/bronchoalveolar-lavage-fluid-neutrophilia-is-associated-with-the-severity-of-pulmonary-lesions-during-equine-asthma-exacerbations
#1
M Bullone, P Joubert, A Gagné, J-Pierre Lavoie, P Hélie
BACKGROUND: The severe form of equine asthma is associated with pathological changes of the peripheral airways and pulmonary parenchyma that are only partly described. Also, the relationship between these structural alterations and the percentage of neutrophils found within the airway lumen, assessed by bronchoalveolar lavage fluid (BALF) cytology, remains ill-defined. OBJECTIVE: To examine the histological lesions associated with equine asthma during disease exacerbation and remission, and their relationship with lung function and BALF neutrophilia...
January 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29338159/ovariectomy-modifies-th2-and-th17-balance-in-balb-c-allergic-mice
#2
Marcos Paulo Almeida Souza, Fernanda Macedo da Silva Lima, Igor Pereira Muniz, Ítalo Sousa Pereira, Larissa Rodrigues de Oliveira Sousa, Maria Poliana Leite Galantini, Denisar Palmito Dos Santos, Tiana Baqueiro Figueiredo, Robson Amaro Augusto da Silva
Asthma is a chronic inflammation of the airways affecting over 300 million people worldwide. As in the autoimmune diseases, it is well described that women are the most affected by asthma. The higher number of women presenting this pathology suggests the involvement of female sex hormones in the construction of the allergic immune response. Female Balb / c mice were used for the experiments. Thirty-eight animals were separated into four groups: OVX-Ova; Sham-Ova; OVX-Sal; Sham-Sal. Then animals underwent acute allergic induction protocol by Ovalbulmin (OVA)...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29336054/the-eaaci-ga%C3%A2-len-edf-wao-guideline-for-the-definition-classification-diagnosis-and-management-of-urticaria-the-2017-revision-and-update
#3
T Zuberbier, W Aberer, R Asero, A H Abdul Latiff, D Baker, B Ballmer-Weber, J A Bernstein, C Bindslev-Jensen, Z Brzoza, R Buense Bedrikow, G W Canonica, M K Church, T Craig, I V Danilycheva, C Dressler, L F Ensina, A Giménez-Arnau, K Godse, M Gonçalo, C Grattan, J Hebert, M Hide, A Kaplan, A Kapp, C H Katelaris, E Kocatürk, K Kulthanan, D Larenas-Linnemann, T A Leslie, M Magerl, P Mathelier-Fusade, R Y Meshkova, M Metz, A Nast, E Nettis, H Oude-Elberink, S Rosumeck, S S Saini, M Sánchez-Borges, P Schmid-Grendelmeier, P Staubach, G Sussman, E Toubi, G A Vena, C Vestergaard, B Wedi, R N Werner, Z Zhao, M Maurer
This evidence and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on December 1st, 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies...
January 15, 2018: Allergy
https://www.readbyqxmd.com/read/29334723/methacholine-bronchial-provocation-test-in-patients-with-asthma-serial-measurements-and-clinical-significance
#4
Hyun-Jung Seo, Pureun-Haneul Lee, Byeong-Gon Kim, Sun-Hye Lee, Jong-Sook Park, Junehyuck Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park, An-Soo Jang
Background/Aims: The methacholine bronchial provocation test (MBPT) is used to detect and quantify airway hyper-responsiveness (AHR). Since improvements in the severity of asthma are associated with improvements in AHR, clinical studies of asthma therapies routinely use the change of airway responsiveness as an objective outcome. The aim of this study was to assess the relationship between serial MBPT and clinical profiles in patients with asthma. Methods: A total of 323 asthma patients were included in this study...
January 17, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29331473/a-randomized-trial-of-itraconazole-versus-prednisolone-in-acute-stage-abpa-complicating-asthma
#5
Ritesh Agarwal, Sahajal Dhooria, Inderpaul Singh Sehgal, Ashutosh N Aggarwal, Mandeep Garg, Biman Saikia, Digambar Behera, Arunaloke Chakrabarti
BACKGROUND AND AIMS: Whether itraconazole monotherapy is effective in the acute-stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. Herein, we compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA. METHODS: We randomized treatment-naïve subjects with ABPA complicating asthma (January 2012 to December 2013) to receive either oral itraconazole or prednisolone for four months. The study was not blinded. The primary outcomes were proportion of subjects showing composite response after six weeks, percentage decline in IgE after treatment, and numbers of subjects experiencing exacerbation...
January 10, 2018: Chest
https://www.readbyqxmd.com/read/29331046/prevalence-severity-and-risk-factors-for-acute-exacerbations-of-nasal-and-sinus-symptoms-by-chronic-rhinosinusitis-status
#6
Jordan R Kuiper, Annemarie G Hirsch, Karen Bandeen-Roche, Agnes S Sundaresan, Bruce K Tan, Robert P Schleimer, Robert C Kern, Walter F Stewart, Brian S Schwartz
BACKGROUND: Nasal and sinus symptoms (NSS) are common to many health conditions, including chronic rhinosinusitis (CRS). Few studies have investigated the occurrence and severity of, and risk factors for, acute exacerbations of NSS (AENSS) by CRS status (current, past, or never met European Position Paper on Rhinosinusitis [EPOS] criteria for CRS). METHODS: Four seasonal questionnaires were mailed to a stratified random sample of Geisinger primary care patients...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29325306/-a-retrospective-study-of-the-inducing-factors-and-clinical-characteristics-of-patients-hospitalized-for-asthma-exacerbation-in-china-in-2013-2014
#7
B Xing, J T Lin, H P Tang, L Yang, Y D Yuan, Y H Gu, P Chen, X J Liu, J Zhang, H G Liu, C Z Wang, W Zhou, D J Sun, Y Q Chen, Z C Chen, M Huang, Q C Lin, C P Hu, X H Yang, J M Huo, X W Ye, X Zhou, P Jiang, W Zhang, Y J Huang, L M Dai, R Y Liu, S X Cai, J Y Xu, J Y Zhou
Objective: To study the inducing factors and clinical characteristics of patients hospitalized for asthma exacerbation in China. Methods: Patients hospitalized for asthma exacerbation at 29 hospitals in China were retrospectively recruited during 2013-2014. Results: Clinical data of 3 240 asthmatic patients were collected and analyzed including 1 369(42.3%) males and 1 871(57.7%) females. The patients hospitalized for asthma exacerbation counted for 2.95% (6 375/215 955) of all patients hospitalized during the same period...
January 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29325303/-standardize-the-management-of-asthma-exacerbation-and-improve-the-treatment-level-of-acute-attack
#8
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29323621/vaccines-for-the-paramyxoviruses-and-pneumoviruses-successes-candidates-and-hurdles
#9
Charles J Russell, Eric A F Simões, Julia L Hurwitz
Human parainfluenza viruses (family Paramyxoviridae), human metapneumovirus, and respiratory syncytial virus (family Pneumoviridae) infect most infants and children within the first few years of life and are the etiologic agents for many serious acute respiratory illnesses. These virus infections are also associated with long-term diseases that impact quality of life, including asthma. Despite over a half-century of vaccine research, development, and clinical trials, no vaccine has been licensed to date for the paramyxoviruses or pneumoviruses for the youngest infants...
January 11, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29320737/genomic-circuitry-underlying-immunological-response-to-pediatric-acute-respiratory-infection
#10
Sarah E Henrickson, Sasikanth Manne, Douglas V Dolfi, Kathleen D Mansfield, Kaela Parkhouse, Rakesh D Mistry, Elizabeth R Alpern, Scott E Hensley, Kathleen E Sullivan, Susan E Coffin, E John Wherry
Acute respiratory tract viral infections (ARTIs) cause significant morbidity and mortality. CD8 T cells are fundamental to host responses, but transcriptional alterations underlying anti-viral mechanisms and links to clinical characteristics remain unclear. CD8 T cell transcriptional circuitry in acutely ill pediatric patients with influenza-like illness was distinct for different viral pathogens. Although changes included expected upregulation of interferon-stimulated genes (ISGs), transcriptional downregulation was prominent upon exposure to innate immune signals in early IFV infection...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29319028/comparison-of-oral-montelukast-with-oral-ozagrel-in-acute-asthma-a-randomized-double-blind-placebo-controlled-study
#11
Rahul Magazine, Vyshak Uddur Surendra, Bharti Chogtu
BACKGROUND: The need for more effective management of acute asthma has led to research on drugs which are otherwise approved for use in chronic asthma. OBJECTIVE: To study and compare the effects of oral montelukast with oral ozagrel in acute asthma. MATERIALS AND METHODS: One hundred and twenty patients with acute asthma were recruited for the study. Out of 120 study patients, forty each were randomized into placebo, montelukast, and ozagrel groups...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29318574/prophylactic-benefits-of-systemically-delivered-simvastatin-treatment-in-a-house-dust-mite-challenged-murine-model-of-allergic-asthma
#12
Aruni Jha, Min H Ryu, O O Ojo, Hilary J Bews, Jules C Carlson, Jacquie Schwartz, Sujata Basu, Charles S Wong, Andrew J Halayko
BACKGROUND AND PURPOSE: Systemically delivered statins can blunt airway inflammation in ovalbumin-challenged mice; however, in asthma clinical trials the beneficial effects of introducing oral statins are not compelling. We aim to reconcile this discrepancy using a clinically relevant murine model of allergic asthma, and by including a prophylactic study arm. EXPERIMENTAL APPROACH: Adult mice were: 1) challenged with house dust mite (HDM) alone or with subcutaneous (s...
January 10, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29316647/role-of-polyamines-in-asthma-pathophysiology
#13
REVIEW
Vaibhav Jain
Asthma is a complex disease of airways, where the interactions of immune and structural cells result in disease outcomes with airway remodeling and airway hyper-responsiveness. Polyamines, which are small-sized, natural super-cations, interact with negatively charged intracellular macromolecules, and altered levels of polyamines and their interactions have been associated with different pathological conditions including asthma. Elevated levels of polyamines have been reported in the circulation of asthmatic patients as well as in the lungs of a murine model of asthma...
January 6, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29315632/food-allergen-sensitized-ccr9-lymphocytes-enhance-airways-allergic-inflammation-in-mice
#14
Laure Castan, Marie-Aude Cheminant, Luc Colas, Sophie Brouard, Antoine Magnan, Grégory Bouchaud
BACKGROUND: The mechanisms of the atopic march, characterized by a natural progression from food and cutaneous allergies to rhinitis and asthma, are still unknown. However, as several organs can be involved, chemokines and their receptors might be implicated in this process and may be instrumental factors. OBJECTIVES: We hypothesized that the T-cell gut-homing receptor CCR9 could be implicated in the evolution of allergic diseases. METHODS: We characterized the immune response and the role of CCR9 in a murine model combining food allergy to wheat gliadin and a model of acute airways inflammation in response to house dust mite...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29314737/airway-inflammation-in-sickle-cell-disease-a-translational-perspective
#15
REVIEW
Aliva De, Deepa Manwani, Deepa Rastogi
Asthma and sickle cell disease (SCD) are common chronic conditions in children of African ancestry that are characterized by cough, wheeze, and obstructive patterns on pulmonary function. Pulmonary function testing in children with SCD has estimated a prevalence of obstructive lung disease ranging from 13% to 57%, and airway hyper-responsiveness of up to 77%, independent of a diagnosis of asthma. Asthma co-existing with SCD is associated with increased risk of acute chest syndrome (ACS), respiratory symptoms, pain episodes, and death...
January 4, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29314338/reduced-cdhr3-expression-in-children-wheezing-with-rhinovirus
#16
Katarina Stenberg Hammar, Katarzyna Niespodziana, Marianne van Hage, Juha Kere, Rudolf Valenta, Gunilla Hedlin, Cilla Söderhäll
BACKGROUND: Rhinovirus induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin related family member 3 (CDHR3) was identified as the RV-C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced RV-C binding and increased replication in vitro. The aim of this study was to examine rs6967330 genotypes and mRNA expression of CDHR3 in relation to presence of rhinovirus and clinical symptoms in children with acute wheezing and compare to a group of age-matched healthy children...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29313715/fluid-balance-is-associated-with-clinical-outcomes-and-extravascular-lung-water-in-children-with-acute-asthma-exacerbation
#17
David B Kantor, Eliotte L Hirshberg, Molly C McDonald, Jonathan Griffin, Tess Buccigrosso, Nicole Stenquist, Craig D Smallwood, Kyle A Nelson, David Zurakowski, Wanda Phipatanakul, Joel N Hirschhorn
RATIONALE: The effects of fluid administration during acute asthma exacerbation are likely unique in this patient population: highly negative inspiratory intrapleural pressure resulting from increased airway resistance may interact with excess fluid administration to favor the accumulation of extravascular lung water, leading to worse clinical outcomes. OBJECTIVES: Investigate how fluid balance influences clinical outcomes in children hospitalized for asthma exacerbation...
January 9, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29309861/protective-effects-of-diketopiperazines-from-moslae-herba-against-influenza-a-virus-induced-pulmonary-inflammation-via-inhibition-of-viral-replication-and-platelets-aggregation
#18
Huan-Huan Zhang, Wen-Ying Yu, Lan Li, Fang Wu, Qin Chen, Yang Yang, Chen-Huan Yu
ETHNOPHARMACROLOGICAL RELEVANCE: Moslae Herba (MH) is broadly used as an antiviral, antipyretic and anticoagulant drug which effectively treats respiratory diseases including cough, asthma, throat, cold and flu. AIM OF THIS STUDY: The excessive inflammation of the lungs is the hallmark of severe influenza A virus (IAV) infection, while platelet aggregation and its subsequent microvascular thrombosis can exacerbate IAV-induced lung injury. Thus, inhibition of platelet aggregation can be a potential target for IAV treatment...
January 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29308548/management-of-recurrent-preschool-doctor-diagnosed-wheeze
#19
REVIEW
Ka-Ka Siu, Shuk-Yu Leung, Sum-Yi Kong, Daniel Kwok-Keung Ng
Preschool wheeze occurs in half of the children before they reach 6 y of age and recurrence is also common. Recurrent preschool wheeze is classified as either typical or atypical. For typical recurrent preschool wheeze, the diagnoses are either asthma or bronchiolitis/bronchitis. Responsiveness to a properly administered bronchodilator confirms asthma, atopic or otherwise. All atypical preschool wheeze should be referred to pediatric respirologist for assessment. Lung function test by impulse oscillometry (IOS) before and after bronchodilator is helpful to confirm airway hyperresponsiveness, an essential feature of asthma...
January 8, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29305409/adjunctive-pharmacotherapies-in-children-with-asthma-exacerbations-requiring-continuous-albuterol-therapy-findings-from-the-ohio-pediatric-asthma-repository
#20
Steven L Shein, Obada Farhan, Nathan Morris, Nabihah Mahmood, Sherman J Alter, Jocelyn M Biagini Myers, Samantha M Gunkelman, Carolyn M Kercsmar, Gurjit K Khurana Hershey, Lisa J Martin, Karen S McCoy, Jennifer R Ruddy, Kristie R Ross
OBJECTIVES: To identify associations between use of ipratropium and/or intravenous magnesium and outcomes of children hospitalized with acute asthma exacerbations and treated with continuous albuterol. METHODS: Secondary analysis of data from children prospectively enrolled in the multicenter Ohio Pediatric Asthma Repository restricted to only children who were treated with continuous albuterol in their initial inpatient location. Children were treated with adjunctive therapies per the clinical team...
January 5, 2018: Hospital Pediatrics
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