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JOURNAL ARTICLE
Bernhard Neumann, Klemens Angstwurm, Christian Dohmen, Philipp Mergenthaler, Siegfried Kohler, Silvia Schönenberger, De-Hyung Lee, Stefan T Gerner, Hagen B Huttner, Andrea Thieme, Andreas Steinbrecher, Juliane Dunkel, Christian Roth, Hauke Schneider, Heinz Reichmann, Hannah Fuhrer, Ingo Kleiter, Christiane Schneider-Gold, Anke Alberty, Jan Zinke, Michael Schroeter, Ralf Linker, Andreas Meisel, Julian Bösel, Henning R Stetefeld
Myasthenic crisis (MC) requiring mechanical ventilation is a serious complication of myasthenia gravis (MG). Here we analyze the frequency and risk factors of weaning- and extubation failure as well as its impact on the clinical course in a large cohort. We performed a retrospective chart review on patients treated for MC in 12 German neurological departments between 2006 and 2015. Weaning failure (WF) was defined as negative spontaneous breathing trial, primary tracheostomy, or extubation failure (EF) (reintubation or death)...
November 3, 2023: Journal of Neurology
#2
REVIEW
Emanuel Raschi, Simone Rossi, Andrea De Giglio, Michele Fusaroli, Flavio Burgazzi, Rita Rinaldi, Luciano Potena
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment and care of patients with cancer owing to unique features, including the occurrence of the so-called immune-related adverse events (irAEs). A multidisciplinary team, possibly including a cardio-oncology specialist, is warranted to achieve a favorable patient outcome. Cardiovascular toxicity, especially myocarditis, emerged as a life-threatening irAE in the real-word setting, and the European Society of Cardiology has recently published the first guideline on cardio-oncology to increase awareness and promote a standardized approach to tackle this complex multimodal issue, including diagnostic challenges, assessment, treatment, and surveillance of patients with cancer receiving ICIs...
June 21, 2023: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
#3
JOURNAL ARTICLE
Debora Brascia, Marco Lucchi, Vittorio Aprile, Melania Guida, Roberta Ricciardi, Federico Rea, Giovanni Maria Comacchio, Marco Schiavon, Maria Carlotta Marino, Stefano Margaritora, Elisa Meacci, Gregorio Spagni, Amelia Evoli, Giulia Lorenzoni, Giulia De Iaco, Angela De Palma, Giuseppe Marulli
OBJECTIVES: Total thymectomy in addition to medical treatment is an accepted standard therapy for myasthenia gravis. Patients with severe generalized myasthenia gravis present life-threatening events, poor prognosis and higher risk of postoperative myasthenic crisis. Aim of our study is to investigate neurological and surgical results in patients with MGFA class IV and V MG following thymectomy. METHODS: Data on 76 myasthenia gravis patients with preoperative MGFA class IV and V who underwent thymectomy were retrospectively collected...
May 10, 2023: European Journal of Cardio-thoracic Surgery
#4
REVIEW
Danilo Coco, Silvana Leanza
Thymectomy is a well-established therapeutic option in the multidisciplinary treatment of nonthymomatous myasthenia gravis (MG) and in thymoma treatment. Although many surgical procedures for thymectomy have been identified, the transsternal method is still regarded as the gold standard. Minimally invasive procedures, on the other hand, have achieved popularity in the last decades and are now extensively used in this field of surgery. Among them, robotic thymectomy has been the most cutting-edge surgical procedure...
March 2023: Polish Journal of Cardio-Thoracic Surgery
#5
JOURNAL ARTICLE
Baiakmenlang Synmon, Sanjib Rawat, Reuben Kynta, Masaraf Hussain, Shri R Sharma, Bifica S Lyngdoh, Baphira Wankhar, Yasmeen Hynniewta
BACKGROUND: Myasthenia gravis (MG) is a neuromuscular junction disorder usually associated with a thymic lesion. AIMS AND OBJECTIVE: To study the clinical, serological, and thymic pathology in patient of MG from this corner of the country. MATERIAL AND METHOD: A retrospective study involving all myasthenia patients presenting to neurology and cardio-thoracic department from the year 2013 to 2020. The clinical findings, Osserman grade of severity, antibodies profile, computed scanning thorax findings and histopathology of the thymic lesion were noted and collected as data...
November 2022: Journal of Family Medicine and Primary Care
#6
EDITORIAL
Pier Luigi Filosso, Matteo Roffinella, Enrico Ruffini
No abstract text is available yet for this article.
October 22, 2021: European Journal of Cardio-thoracic Surgery
#7
Francesco Guerrera, Pierre Emmanuel Falcoz, Bernhard Moser, Dirk van Raemdonck, Andrea Bille, Alper Toker, Lorenzo Spaggiari, Luca Ampollini, Claudia Filippini, Pascal Alexandre Thomas, Bram Verdonck, Paolo Mendogni, Clemens Aigner, Luca Voltolini, Nuria Novoa, Miriam Patella, Sara Mantovani, Ivan Gomes Bravio, Charalambos Zisis, Angela Guirao, Francesco Londero, Miguel Congregado, Gaetano Rocco, Bert Du Pont, Nicola Martucci, Matthias Esch, Alessandro Brunelli, Frank C Detterbeck, Federico Venuta, Walter Weder, Enrico Ruffini, Walter Klepetko, Anne Olland, Bert DuPont, Daisuke Nonaka, Berker Ozkan, Giorgio Lo Iacono, Cesare Braggio, Pier Luigi Filosso, Geoffrey Brioude, Paul van Schil, Mario Nosotti, Daniel Valdivia, Stefano Bongiolatti, Ilhan Inci, Rontogianni Dimitra, David Sànchez, William Grossi, Sergio Moreno-Merino, Martin Teschner
No abstract text is available yet for this article.
October 22, 2021: European Journal of Cardio-thoracic Surgery
#8
JOURNAL ARTICLE
Qing Zhou, Xiaoyu Huang, Caiqiang Xue, Junlin Zhou
OBJECTIVES: Our goal was to investigate the correlation of clinical and computed tomography (CT) features of thymic epithelial tumours (TET) with the World Health Organization classification and the Masaoka-Koga staging system. METHODS: Clinical and CT imaging data from 159 patients surgically and pathologically diagnosed with TET (82 men, 77 women; mean [± standard deviation] age, 52.08 ± 11.76 years) were retrospectively collected and reviewed. CT features were evaluated by radiologists...
July 30, 2021: European Journal of Cardio-thoracic Surgery
#9
EDITORIAL
Alper Toker, Jahnavi Kakuturu
No abstract text is available yet for this article.
October 22, 2021: European Journal of Cardio-thoracic Surgery
#10
JOURNAL ARTICLE
Gaetano Romano, Carmelina Cristina Zirafa, Ilaria Ceccarelli, Melania Guida, Federico Davini, Michelangelo Maestri, Riccardo Morganti, Roberta Ricciardi, Teresa Hung Key, Franca Melfi
OBJECTIVES: The goal of this study was to analyse the outcomes in 53 patients with thymoma, 34 of whom had myasthenia gravis (MG), who were treated with robotic surgery. The oncological outcomes of the whole series of patients were analysed. Furthermore, because consistent data are not yet available in the literature, the main focus was the analysis of the neurological results of the patients affected by MG and thymoma. METHODS: The clinical outcomes of 53 patients with a diagnosis of thymoma who underwent robotic thymectomy between January 2014 and December 2019 in our institution were collected and evaluated; 34 of these patients had a concomitant diagnosis of MG...
October 22, 2021: European Journal of Cardio-thoracic Surgery
#11
REVIEW
T V Romanova
This review analyzes publications that present data on sleep disorders in patients with myasthenia gravis (MG). The analysis is based on domestic and foreign publications that are freely available over the past 30 years. Sleep disorders, the most significant of which are sleep-related respiratory disorders, are one of the factors that cause quality of life decreasing and mortality in patients with neuromuscular diseases. The issues of prevalence of breathing disorders during sleep, relationship of these disorders with clinical and immunological characteristics of disease, demographic indicators are studied...
2021: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#12
LETTER
Hanlu Zhang, Long-Qi Chen, Yun Wang
No abstract text is available yet for this article.
October 22, 2021: European Journal of Cardio-thoracic Surgery
#13
JOURNAL ARTICLE
Francesco Guerrera, Pierre Emmanuel Falcoz, Bernhard Moser, Dirk van Raemdonck, Andrea Bille', Alper Toker, Lorenzo Spaggiari, Luca Ampollini, Claudia Filippini, Pascal Alexandre Thomas, Bram Verdonck, Paolo Mendogni, Clemens Aigner, Luca Voltolini, Nuria Novoa, Miriam Patella, Sara Mantovani, Ivan Gomes Bravio, Charalambos Zisis, Angela Guirao, Francesco Londero, Miguel Congregado, Gaetano Rocco, Bert Du Pont, Nicola Martucci, Matthias Esch, Alessandro Brunelli, Frank C Detterbeck, Federico Venuta, Walter Weder, Enrico Ruffini, Walter Klepetko, Anne Olland, Bert Du Pont, Daisuke Nonaka, Berker Ozkan, Giorgio Lo Iacono, Cesare Braggio, Pier Luigi Filosso, Geoffrey Brioude, Paul van Schil, Mario Nosotti, Daniel Valdivia, Stefano Bongiolatti, Ilhan Inci, Rontogianni Dimitra, David Sànchez, William Grossi, Sergio Moreno-Merino, Martin Teschner
OBJECTIVES: Resection of thymic tumours including the removal of both the tumour and the thymus gland (thymothymectomy; TT) is the procedure of choice and is recommended in most relevant articles in the literature. Nevertheless, in recent years, some authors have suggested that resection of the tumour (simple thymomectomy; ST) may suffice from an oncological standpoint in patients with early-stage thymoma who do not have myasthenia gravis (MG) (non-MG). The goal of our study was to compare the short- and long-term outcomes of ST versus TT in non-MG early-stage thymomas using the European Society of Thoracic Surgeons thymic database...
October 22, 2021: European Journal of Cardio-thoracic Surgery
#14
Arvind Kumar, Belal Bin Asaf, Mohan Venkatesh Pulle, Harsh Vardhan Puri, Nitin Sethi, Sukhram Bishnoi
No abstract text is available yet for this article.
July 30, 2021: European Journal of Cardio-thoracic Surgery
#15
JOURNAL ARTICLE
Candice L Wilshire, Sandra L Blitz, Carson C Fuller, Jens C Rückert, Feng Li, Robert J Cerfolio, Asem F Ghanim, Mark W Onaitis, Inderpal S Sarkaria, Dennis A Wigle, Vijay Joshi, Scott Reznik, Adam J Bograd, Eric Vallières, Brian E Louie
OBJECTIVES: Complete thymectomy is a key component of the optimal treatment for myasthenia gravis. Unilateral, minimally invasive approaches are increasingly utilized with debate about the optimal laterality approach. A right-sided approach has a wider field of view, while a left-sided approach accesses potentially more thymic tissue. We aimed to assess the impact of laterality on perioperative and medium-term outcomes, and to identify predictors of a 'good outcome' using standard definitions...
October 22, 2021: European Journal of Cardio-thoracic Surgery
#16
JOURNAL ARTICLE
Jennifer Cautela, Sarah Zeriouh, Melanie Gaubert, Laurent Bonello, Marc Laine, Michael Peyrol, Franck Paganelli, Nathalie Lalevee, Fabrice Barlesi, Franck Thuny
BACKGROUND: Myocarditis is a rare but life-threatening adverse event of cancer treatments with immune checkpoint inhibitors (ICIs). Recent guidelines recommend the use of high doses of corticosteroids as a first-line treatment, followed by intensified immunosuppressive therapy (IIST) in the case of unfavorable evolution. However, this strategy is empirical, and no studies have specifically addressed this issue. Therefore, we aimed to investigate and compare the clinical course, management and outcome of ICI-induced myocarditis patients requiring or not requiring IIST...
December 2020: Journal for Immunotherapy of Cancer
#17
JOURNAL ARTICLE
Arvind Kumar, Belal Bin Asaf, Mohan Venkatesh Pulle, Harsh Vardhan Puri, Nitin Sethi, Sukhram Bishnoi
OBJECTIVES: The goal of this study was to compare the early and intermediate surgical outcomes, including the survival of those with and without myasthenic thymoma, following robotic thymectomy. METHODS: This is a retrospective analysis of prospectively maintained data of 111 patients who underwent robotic thymectomy for thymoma over 7 years in a thoracic surgery centre in India. We performed a comparative analysis of demographics, intraoperative variables and postoperative outcomes including survival of those with and without myasthenic thymoma...
April 29, 2021: European Journal of Cardio-thoracic Surgery
#18
MULTICENTER STUDY
Tomoyuki Hishida, Hisao Asamura, Kazuo Yoshida, Masahiro Tsuboi, Kohei Yokoi, Shinichi Toyooka, Akihide Matsumura, Tetsuzo Tagawa, Meinoshin Okumura
OBJECTIVES: The purpose of this study was to clarify the prevalence, clinical features and survival of patients with thymoma and non-myasthenia gravis autoimmune disease (NMAD) using a nationwide cohort. METHODS: The Japanese Association for Research on the Thymus nationwide database, which includes data from 32 institutions, was examined to clarify the prevalence and characteristics of NMAD associated with thymomas and elucidate the prognostic impact of NMAD for thymoma patients...
April 13, 2021: European Journal of Cardio-thoracic Surgery
#19
JOURNAL ARTICLE
Josef Finsterer, Claudia Stöllberger, Chen-Yu Ho
BACKGROUND: Takotsubo syndrome (TTS) is a non-ischaemic cardiomyopathy with sudden but transient systolic dysfunction. TTS mimics myocardial infarction clinically, chemically, and electrocardiographically but echocardiography typically shows apical ballooning and coronary angiography is normal. TTS has not been reported in a patient with myasthenia gravis (MG) and polymyositis due to a malignant thymoma. CASE REPORT: Two weeks prior to admission, a 76-year-old female developed dysarthria, chronic coughing and disabling myalgias of the entire musculature...
December 2018: International Journal of Neuroscience
#20
JOURNAL ARTICLE
Francesco Paolo Caronia, Alfonso Fiorelli, Ettore Arrigo, Sebastiano Trovato, Mario Santini, Attilio Ignazio Lo Monte
BACKGROUND: Video-assisted thoracoscopy is become a widely accepted approach for the resection of anterior mediastinal masses, including thymoma. The current trend is to reduce the number of ports and minimize the length of incisions to further decrease postoperative pain, chest wall paresthesia, and length of hospitalization. Herein, we reported an extended resection of thymoma in a patient with myasthenia gravis through an uniportal bilateral thoracoscopic approach. CASE PRESENTATION: A 74 years old woman with myasthenia gravis was referred to our attention for management of a 3...
November 22, 2016: Journal of Cardiothoracic Surgery
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