Pawel Szulc, Alyssa B Dufour, Marian T Hannan, Douglas P Kiel, Roland Chapurlat, Elisabeth Sornay-Rendu, Blandine Merle, Steven K Boyd, Danielle E Whittier, David A Hanley, David Goltzman, Andy Kin On Wong, Eric Lespessailles, Sundeep Khosla, Serge Ferrari, Emmanuel Biver, Mary L Bouxsein, Elizabeth J Samelson
Fracture risk increases with lower areal BMD (aBMD); however, aBMD-related estimate of risk may decrease with age. This may depend on technical limitations of 2-dimensional (2D) DXA which are reduced with 3D high-resolution peripheral quantitative computed tomography (HR-pQCT). Our aim was to examine whether the predictive utility of HR-pQCT measures with fracture varies with age. We analyzed associations of HR-pQCT measures at the distal radius and distal tibia with two outcomes: incident fractures and major osteoporotic fractures...
March 3, 2024: Journal of Bone and Mineral Research