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https://www.readbyqxmd.com/read/29447277/correction-generation-of-g-protein-coupled-receptor-antibodies-differentially-sensitive-to-conformational-states
#1
Andrea S Heimann, Achla Gupta, Ivone Gomes, Rayees Rahman, Avner Schlessinger, Emer S Ferro, Ellen M Unterwald, Lakshmi A Devi
[This corrects the article DOI: 10.1371/journal.pone.0187306.].
2018: PloS One
https://www.readbyqxmd.com/read/29440941/sleep-disturbances-in-women-with-polycystic-ovary-syndrome-prevalence-pathophysiology-impact-and-management-strategies
#2
REVIEW
Renae C Fernandez, Vivienne M Moore, Emer M Van Ryswyk, Tamara J Varcoe, Raymond J Rodgers, Wendy A March, Lisa J Moran, Jodie C Avery, R Doug McEvoy, Michael J Davies
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting the reproductive, metabolic and psychological health of women. Clinic-based studies indicate that sleep disturbances and disorders including obstructive sleep apnea and excessive daytime sleepiness occur more frequently among women with PCOS compared to comparison groups without the syndrome. Evidence from the few available population-based studies is supportive. Women with PCOS tend to be overweight/obese, but this only partly accounts for their sleep problems as associations are generally upheld after adjustment for body mass index; sleep problems also occur in women with PCOS of normal weight...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29439086/using-photography-to-enhance-gp-trainees-reflective-practice-and-professional-development
#3
Rutherford, Emer Forde, Jacqueline Priego-Hernandez, Aurelia Butcher, Clare Wedderburn
The capacity and the commitment to reflect are integral to the practice of medicine and are core components of most general practitioners (GP) training programmes. Teaching through the humanities is a growing area within medical education, but one which is often considered a voluntary 'add-on' for the interested doctor. This article describes an evaluation of a highly innovative pedagogical project which used photography as a means to enhance GP trainees' reflective capacity, self-awareness and professional development...
February 8, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29436686/downregulation-of-the-long-non-coding-rna-xloc_010588-inhibits-the-invasion-and-migration-of-colorectal-cancer
#4
Yue Li, Lin Zhao, Yining Zhang, Lin Guan, Huijing Zhang, Huan Zhou, Tong Gao, Peng Miao, Mingjun Sun
Long non-coding RNAs (lncRNAs) have emer-ged as major players in many biological and pathological processes; however, investigation into the function of lncRNAs in the development and progression of cancer is in its infancy. Therefore, clarification of the mechanism by which cancer‑related lncRNAs function is of critical importance in research on tumorigenesis. It has been demonstrated that the lncRNA XLOC_010588 is expressed at a low level in cervical cancer, and that this has significant impact on the proliferation of cervical cancer cells...
February 12, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29432137/air-travel-for-subjects-receiving-long-term-oxygen-therapy
#5
Christina D Campbell, Matthew W Smyth, Lindsay Brown, Emer Kelly
BACKGROUND: Ambulatory oxygen (O2) is the recommended treatment for hypoxemia at rest or induced by exercise. Commercial aircraft often fly at altitudes of 30,000 feet; their cabins are pressurized to altitudes of 6,000-8,000 feet, with an equivalent FIO2 of 0.15.O2 supplementation, for those receiving baseline ambulatory O2, is paramount. METHODS: We gathered information on subjects' experience traveling with supplementary oxygen and reasons individuals receiving O2 do not travel...
February 6, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29431103/interaction-of-body-mass-index-on-the-association-between-n-terminal-pro-b-type-natriuretic-peptide-and-morbidity-and-mortality-in-patients-with-acute-heart-failure-findings-from-ascend-hf-acute-study-of-clinical-effectiveness-of-nesiritide-in-decompensated
#6
Ankeet S Bhatt, Lauren B Cooper, Andrew P Ambrosy, Robert M Clare, Adrian Coles, Emer Joyce, Arun Krishnamoorthy, Javed Butler, G Michael Felker, Justin A Ezekowitz, Paul W Armstrong, Adrian F Hernandez, Christopher M O'Connor, Robert J Mentz
BACKGROUND: Higher body mass index (BMI) is associated with lower circulating levels of N-terminal-pro-b-type natriuretic peptide (NT-proBNP). The Interaction between BMI and NT-proBNP with respect to clinical outcomes is not well characterized in patients with acute heart failure. METHODS AND RESULTS: A total of 686 patients from the biomarker substudy of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated HF ) clinical trial with documented NT-proBNP levels at baseline were included in the present analysis...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29429619/first-pass-processing-of-value-cues-in-the-ventral-visual-pathway
#7
Dennis Sasikumar, Erik Emeric, Veit Stuphorn, Charles E Connor
Real-world value often depends on subtle, continuously variable visual cues specific to particular object categories, like the tailoring of a suit, the condition of an automobile, or the construction of a house. Here, we used microelectrode recording in behaving monkeys to test two possible mechanisms for category-specific value-cue processing: (1) previous findings suggest that prefrontal cortex (PFC) identifies object categories, and based on category identity, PFC could use top-down attentional modulation to enhance visual processing of category-specific value cues, providing signals to PFC for calculating value, and (2) a faster mechanism would be first-pass visual processing of category-specific value cues, immediately providing the necessary visual information to PFC...
February 5, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29423825/non-operative-treatment-of-appendicitis-public-perception-and-decision-making
#8
Emer P O'Connell, Annmarie White, Paul Cromwell, Emma Carroll, Waqar Khan, Ronan Waldron, Iqbal Z Khan, Kevin Barry
BACKGROUND: Appendectomy has for many years been the accepted treatment of appendicitis. In recent years, non-operative management of appendicitis (NOTA) has been reported as an effective treatment option. AIMS: We aimed to assess the perspectives of public hospital attendees regarding the diagnosis and treatment options for appendicitis. METHODS: We conducted a cross-sectional survey of outpatients over a 10-week period (December 2016-March 2017)...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29409960/the-developing-human-connectome-project-a-minimal-processing-pipeline-for-neonatal-cortical-surface-reconstruction
#9
Antonios Makropoulos, Emma C Robinson, Andreas Schuh, Robert Wright, Sean Fitzgibbon, Jelena Bozek, Serena J Counsell, Johannes Steinweg, Katy Vecchiato, Jonathan Passerat-Palmbach, Gregor Lenz, Filippo Mortari, Tencho Tenev, Eugene P Duff, Matteo Bastiani, Lucilio Cordero-Grande, Emer Hughes, Nora Tusor, Jacques-Donald Tournier, Jana Hutter, Anthony N Price, Rui Pedro A G Teixeira, Maria Murgasova, Suresh Victor, Christopher Kelly, Mary A Rutherford, Stephen M Smith, A David Edwards, Joseph V Hajnal, Mark Jenkinson, Daniel Rueckert
The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following established best practices adopted by the WU-MINN Human Connectome Project (HCP), and pioneered by FreeSurfer, the project utilises cortical surface-based processing pipelines. In this paper, we propose a fully automated processing pipeline for the structural Magnetic Resonance Imaging (MRI) of the developing neonatal brain...
January 30, 2018: NeuroImage
https://www.readbyqxmd.com/read/29408946/poor-adherence-to-risk-stratification-guidelines-results-in-overuse-of-venous-thromboembolism-prophylaxis-in-hospitalized-older-adults
#10
Juliessa M Pavon, Richard J Sloane, Carl F Pieper, Cathleen S Colón-Emeric, Harvey J Cohen, David Gallagher, Miriam C Morey, Midori McCarty, Thomas L Ortel, Susan N Hastings
No abstract text is available yet for this article.
February 6, 2018: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29407518/hospital-readmissions-among-total-hip-replacement-patients-in-2009-and-2014
#11
Michael P Cary, Victoria Goode, Nancy Crego, Deirdre Thornlow, Cathleen Colón-Emeric, Helen M Hoenig, Kayla Baba, Scarlet Fellingham, Elizabeth I Merwin
OBJECTIVE: To document changes in 30-day hospital readmission rates and causes for returning to the hospital for care among THR patients in US hospitals in 2009 and 2014. DESIGN: Cross-sectional, retrospective descriptive. We used data from the Nationwide Readmissions Database (NRD) which is drawn from the Healthcare Cost and Utilization Project (HCUP) net - sponsored by the Agency for Healthcare Research and Quality (AHRQ). SETTING: The AHRQ database, known as NRD, is based on a 20% sample of all hospital discharges in the nation...
January 30, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29401354/severe-sympathomimetic-toxidrome-in-a-french-soldier-how-caffeine-overdose-can-lead-to-severe-consequences
#12
Philippe Laitselart, Emeric Saguin, Julie Plantamura, Bertrand Lahutte, Hervé Delacour, Clément Dubost
We report the case of a French soldier, 29-yr-old, hospitalized in intensive care unit at Begin Military Hospital for the management of a sympathomimetic syndrome associated with severe metabolic disorders. Diagnosis of voluntary caffeine overdose was made. The evolution was favorable after metabolic disorders correction, without the need for dialysis. Caffeine is a molecule free of serious adverse effects when consumed at low doses. However, when consumed at high doses, it can become toxic and lead to death...
January 1, 2018: Military Medicine
https://www.readbyqxmd.com/read/29398629/post-op-a-strategy-to-improve-clinical-documentation-in-the-early-postoperative-period
#13
Paul M Cromwell, Michael Flood, Emer O Connell, Waqar Khan, Ronan Waldron, Iqbal Khan, Kevin Barry
OBJECTIVE: To construct and pilot an educational tool to improve the quality of postoperative documentation at Mayo University Hospital. DESIGN: Retrospective data were collected from 100 consecutive patients treated surgically during October to November 2016. The first written ward based note following surgery was analyzed against RCS quality standards outlined in "Good Surgical Practice." An educational tool was then constructed to improve postoperative documentation...
February 1, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29393050/sphenoid-bone-fibrous-dysplasia-detected-incidentally-on-bone-scintigraphy-by-the-contribution-of-spect-ct-hybrid-imaging
#14
Hüseyin Şan, Kürşat Okuyucu, Ali Ozan Öner, Özdeş Emer, Alper Özgür Karaçalıoğlu
Fibrous dysplasia (FD) is a benign fibroosseous bone disorder. It has poliostotic and monostotic patterns. Monostotic FD is frequently asymptomatic and is usually discovered incidentally by radiologic imaging performed for other reasons. Bone scintigraphy is valuable for identifying disease extent. Craniofacial FD (CFD) is a form of the disease where lesions are limited to contiguous bones of the craniofacial skeleton. We presented a case with monostotic CFD who was detected incidentally on bone scintigraphy single-photon emission computed tomography/computerized tomography while being investigated for inflammatory arthropaties...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29386023/public-health-opportunities-and-challenges-in-the-provision-of-partner-notification-services-the-new-england-experience
#15
Sarah Magaziner, Madeline C Montgomery, Thomas Bertrand, Daniel Daltry, Heidi Jenkins, Brenda Kendall, Lauren Molotnikov, Lindsay Pierce, Emer Smith, Lynn Sosa, Jacob J van den Berg, Theodore Marak, Don Operario, Philip A Chan
BACKGROUND: Partner notification services (PNS) are recommended by the Centers for Disease Control and Prevention as a public health intervention for addressing the spread of HIV and other sexually transmitted diseases (STDs). Barriers and facilitators to the partner notification process from a public health perspective have not been well described. METHODS: In 2015, a coalition of New England public health STD directors and investigators formed to address the increasing STD prevalence across the region (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont) and to promote communication between state STD programs...
January 31, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29358673/lysophosphatidylcholine-acyltransferase-2-mediated-lipid-droplet-production-supports-colorectal-cancer-chemoresistance
#16
Alexia Karen Cotte, Virginie Aires, Maxime Fredon, Emeric Limagne, Valentin Derangère, Marion Thibaudin, Etienne Humblin, Alessandra Scagliarini, Jean-Paul Pais de Barros, Patrick Hillon, François Ghiringhelli, Dominique Delmas
Lipid droplet (LD) accumulation is a now well-recognised hallmark of cancer. However, the significance of LD accumulation in colorectal cancer (CRC) biology is incompletely understood under chemotherapeutic conditions. Since drug resistance is a major obstacle to treatment success, we sought to determine the contribution of LD accumulation to chemotherapy resistance in CRC. Here we show that LD content of CRC cells positively correlates with the expression of lysophosphatidylcholine acyltransferase 2 (LPCAT2), an LD-localised enzyme supporting phosphatidylcholine synthesis...
January 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29356341/cryopreserved-neonatal-hepatocytes-may-be-a-source-for-transplantation-evaluation-of-functionality-towards-clinical-use
#17
Charlotte A Lee, Anil Dhawan, Valeria Iansante, Sharon Lehec, Shirin Elizabeth Khorsandi, Celine Filippi, Simon Walker, Raquel Fernandez-Dacosta, Nigel Heaton, Sanjay Bansal, Ragai R Mitry, Emer Fitzpatrick
Neonatal livers are a potential source of good quality hepatocytes for clinical transplantation. We compared viability and function of neonatal and adult hepatocytes, and report their clinical use both intra-portally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1 antitrypsin and factor VII. Metabolic function was investigated by measuring resorufin conjugation, ammonia metabolism, UGT enzyme activity and cytochrome P450 function following induction...
January 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29356139/rates-of-chemical-reactions-embedded-in-a-metabolic-network-by-dissolution-dynamic-nuclear-polarization-nmr
#18
Aude Sadet, Emmanuelle Weber, Aditya Jhajharia, Dennis Kurzbach, Geoffrey Bodenhausen, Emeric Miclet, Daniel Abergel
The isomerisation of 6-phosphogluconolactones and their hydrolyses into 6-phosphogluconic acid form a non enzymatic side cycle of the pentose-phosphate pathway (PPP) in cells. We show that dissolution dynamic nuclear polarization can be used for determining its kinetic rates in real time. It is found that the hydrolysis of both lactones is significantly slower than the isomeration process, thereby shedding new light onto this subtle and puzzling chemical process.
January 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29356101/eryptosis-and-hemorheological-responses-to-maximal-exercise-in-athletes-comparison-between-running-and-cycling
#19
Elie Nader, Nicolas Guillot, Louis Lavorel, Ivan Hancco, Romain Fort, Emeric Stauffer, Céline Renoux, Philippe Joly, Michèle Germain, Philippe Connes
We compared the effects of cycling and running exercise on hemorheological and hematological properties, as well as eryptosis markers. Seven endurance-trained subjects randomly performed a progressive and maximal exercise test on a cycle ergometer and a treadmill. Blood was sampled at rest and at the end of the exercise to analyze hematological and blood rheological parameters including hematocrit (Hct), red blood cell (RBC) deformability, aggregation and blood viscosity. Hemoglobin saturation (SpO2), blood lactate and glucose levels were also monitored...
January 21, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29353234/psychiatric-symptoms-in-preclinical-behavioural-variant-frontotemporal-dementia-in-mapt-mutation-carriers
#20
Gayathri Cheran, Hannah Silverman, Masood Manoochehri, Jill Goldman, Seonjoo Lee, Liwen Wu, Sarah Cines, Emer Fallon, Brendan Desmond Kelly, Diana Angelika Olszewska, Judith Heidebrink, Sarah Shair, Stephen Campbell, Henry Paulson, Timothy Lynch, Stephanie Cosentino, Edward D Huey
OBJECTIVE: To characterise psychiatric symptoms in preclinical and early behavioural-variant frontotemporal dementia (bvFTD), a neurodegenerative disorder whose symptoms overlap with and are often mistaken for psychiatric illness. METHODS: The present study reports findings from a systematic, global, prospective evaluation of psychiatric symptoms in 12 preclinical carriers of pathogenic MAPT mutations, not yet meeting bvFTD diagnostic criteria, and 46 familial non-carrier controls...
January 20, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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