keyword
MENU ▼
Read by QxMD icon Read
search

Emer

keyword
https://www.readbyqxmd.com/read/29197960/sarcopenia-during-neoadjuvant-therapy-for-oesophageal-cancer-characterising-the-impact-on-muscle-strength-and-physical-performance
#1
Emer M Guinan, S L Doyle, A E Bennett, L O'Neill, J Gannon, J A Elliott, J O'Sullivan, J V Reynolds, J Hussey
PURPOSE: Preoperative chemo(radio)therapy for oesophageal cancer (OC) may have an attritional impact on body composition and functional status, impacting postoperative outcome. Physical decline with skeletal muscle loss has not been previously characterised in OC and may be amenable to physical rehabilitation. This study characterises skeletal muscle mass and physical performance from diagnosis to post-neoadjuvant therapy in patients undergoing preoperative chemo(radio)therapy for OC...
December 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29193244/an-efficient-sequence-for-fetal-brain-imaging-at-3t-with-enhanced-t1-contrast-and-motion-robustness
#2
Giulio Ferrazzi, Anthony N Price, Rui Pedro A G Teixeira, Lucilio Cordero-Grande, Jana Hutter, Ana Gomes, Francesco Padormo, Emer Hughes, Torben Schneider, Mary Rutherford, Maria Kuklisova Murgasova, Joseph V Hajnal
PURPOSE: Ultrafast single-shot T2 -weighted images are common practice in fetal MR exams. However, there is limited experience with fetal T1 -weighted acquisitions. This study aims at establishing a robust framework that allows fetal T1 -weighted scans to be routinely acquired in utero at 3T. METHODS: A 2D gradient echo sequence with an adiabatic inversion was optimized to be robust to fetal motion and maternal breathing optimizing grey/white matter contrast at the same time...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29190710/the-association-between-depressive-symptoms-and-insulin-resistance-inflammation-and-adiposity-in-men-and-women
#3
M'Balu Webb, Melanie Davies, Nuzhat Ashra, Danielle Bodicoat, Emer Brady, David Webb, Calum Moulton, Khalida Ismail, Kamlesh Khunti
INTRODUCTION: Depression has been shown to be associated with elevated leptin levels, low-grade inflammation and insulin resistance. These derangements are often measured in mixed gender cohorts despite the different body compositions and hormonal environments of men and women and gender-specific prevalence and responses to depression. METHODS: A cross-sectional analysis was carried out on a cohort of 639 participants from the ADDITION-Leicester dataset to assess differences in markers of diabetes risk, cardiovascular risk and inflammation in depressed and non-depressed individuals...
2017: PloS One
https://www.readbyqxmd.com/read/29174560/resident-vignettes-for-assessing-care-quality-in-nursing-homes
#4
Cathleen S Colón-Emeric, Kirsten N Corazzini, Eleanor S McConnell, Wei Pan, Mark P Toles, Rasheeda Hall, Melissa Batchelor-Murphy, Tracey L Yap, Amber L Anderson, Andrew Burd, Sathya Amarasekara, Ruth A Anderson
OBJECTIVES: Validated process measures that correlate with patient outcomes are needed for research and quality improvement. DESIGN: Cross-sectional analysis within a cluster-randomized fall prevention study. SETTING: Nursing homes in North Carolina (n = 16). PARTICIPANTS: Nursing home staff (n = 541) and residents with 1 or more falls in 6 months (n = 597). MEASUREMENTS: Fall-prevention process measures in 4 categories derived from Assessing Care of Vulnerable Elders quality indicators were measured in 2 ways: (1) chart abstraction; and (2) staff responses to clinical vignettes of hypothetical residents at risk for falls...
November 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29162664/christmas-connections
#5
Emer McLoughlin, Helen Williams
No abstract text is available yet for this article.
December 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29151608/the-eso-diffuse-interstellar-bands-large-exploration-survey-edibles-i-project-description-survey-sample-and-quality-assessment
#6
Nick L J Cox, Jan Cami, Amin Farhang, Jonathan Smoker, Ana Monreal-Ibero, Rosine Lallement, Peter J Sarre, Charlotte C M Marshall, Keith T Smith, Christopher J Evans, Pierre Royer, Harold Linnartz, Martin A Cordiner, Christine Joblin, Jacco Th van Loon, Bernard H Foing, Neil H Bhatt, Emeric Bron, Meriem Elyajouri, Alex de Koter, Pascale Ehrenfreund, Atefeh Javadi, Lex Kaper, Habib G Khosroshadi, Mike Laverick, Franck Le Petit, Giacomo Mulas, Evelyne Roueff, Farid Salama, Marco Spaans
The carriers of the diffuse interstellar bands (DIBs) are largely unidentified molecules ubiquitously present in the interstellar medium (ISM). After decades of study, two strong and possibly three weak near-infrared DIBs have recently been attributed to the [Formula: see text] fullerene based on observational and laboratory measurements. There is great promise for the identification of the over 400 other known DIBs, as this result could provide chemical hints towards other possible carriers. In an effort to systematically study the properties of the DIB carriers, we have initiated a new large-scale observational survey: the ESO Diffuse Interstellar Bands Large Exploration Survey (EDIBLES)...
October 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29149103/human-hepatocyte-transplantation-for-liver-disease-current-status-and-future-perspectives
#7
REVIEW
Valeria Iansante, Ragai R Mitry, Céline Filippi, Emer Fitzpatrick, Anil Dhawan
Liver transplantation is the accepted treatment for patients with acute liver failure and liver-based metabolic disorders. However, donor organ shortage and lifelong need for immunosuppression are the main limitations to liver transplantation. In addition, loss of the native liver as target organ for future gene therapy for metabolic disorders limits the futuristic treatment options, resulting in the need for alternative therapeutic strategies. A potential alternative to liver transplantation is allogeneic hepatocyte transplantation...
November 14, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29144158/glycosylation-repurposes-alpha-1-antitrypsin-for-resolution-of-community-acquired-pneumonia
#8
Cormac McCarthy, Danielle M Dunlea, Radka Saldova, Michael Henry, Paula Meleady, Oliver J McElvaney, Brian Marsh, Pauline M Rudd, Emer P Reeves, Noel G McElvaney
No abstract text is available yet for this article.
November 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29141145/homochiral-versus-heterochiral-trifluoromethylated-pseudoproline-containing-dipeptides-a-powerful-tool-to-switch-the-prolyl-amide-bond-conformation
#9
Grégory Chaume, Julien Simon, Nathalie Lensen, Julien Pytkowicz, Thierry Brigaud, Emeric Miclet
The design of constrained peptides is of prime importance in the development of bioactive compounds and for applications in supramolecular chemistry. Due to its nature, the peptide bond undergoes a spontaneous cis-trans isomerism and the cis isomers are much more difficult to stabilize than the trans forms. By using oxazolidine-based pseudoprolines (ΨPro) substituted by a trifluoromethyl group, we show that the cis peptide bond can be readily switched from 0% to 100% in Xaa-ΨPro dipeptides. Our results prove that changing the configuration of the Cα in Xaa or in ΨPro is sufficient to invert the cis:trans populations while changing the nature of the Xaa side chain finely tuned the conformers ratio...
November 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29136649/discordance-between-actual-and-scheduled-check-in-times-at-a-heart-failure-clinic
#10
Eiran Z Gorodeski, Emer Joyce, Benjamin T Gandesbery, Eugene H Blackstone, David O Taylor, W H Wilson Tang, Randall C Starling, Rory Hachamovitch
INTRODUCTION: A 2015 Institute Of Medicine statement "Transforming Health Care Scheduling and Access: Getting to Now", has increased concerns regarding patient wait times. Although waiting times have been widely studied, little attention has been paid to the role of patient arrival times as a component of this phenomenon. To this end, we investigated patterns of patient arrival at scheduled ambulatory heart failure (HF) clinic appointments and studied its predictors. We hypothesized that patients are more likely to arrive later than scheduled, with progressively later arrivals later in the day...
2017: PloS One
https://www.readbyqxmd.com/read/29127877/breast-arterial-calcification-on-screening-mammography-can-predict-significant-coronary-artery-disease-in-women
#11
Brendan S Kelly, Emer ScanlON, Helen Heneghan, Ciaran E Redmond, Gerard M Healy, Enda Mc Dermott, Eric J Heffernan, Ruth Prichard, Sorcha Mc Nally
INTRODUCTION: Breast Arterial Calcification (BAC) on digital mammography has been associated with an increased risk of Coronary Artery Disease (CAD). We aimed to investigate the association of BAC with findings on Coronary Computed Tomography Angiography (CCTA) within a cohort of women from the national breast screening program. METHODS: Symptomatic women (chest pain) aged between 50 and 65 who underwent a CCTA and who also had a screening mammography between 2014 and 2015 were recorded...
November 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29122831/fifteen-minute-consultation-liver-disease-in-children
#12
Jake P Mann, Kathy Gallagher, Emer Fitzpatrick, Anil Dhawan
Liver disease in children can present in many ways from the frequently encountered prolonged neonatal jaundice to the comparatively rare acute liver failure. In this article, we will discuss 'red flags' of liver disease, the initial investigations required and when to refer to a specialist liver centre. Across all presentations, the degree of elevation of alanine aminotransferase or aspartate aminotransferase provides only little diagnostic information. Measurement of clotting is vital, and coagulopathy should be followed by a trial of intravenous vitamin K before being repeated...
November 9, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29118365/impaired-development-of-the-cerebral-cortex-in-infants-with-congenital-heart-disease-is-correlated-to-reduced-cerebral-oxygen-delivery
#13
Christopher J Kelly, Antonios Makropoulos, Lucilio Cordero-Grande, Jana Hutter, Anthony Price, Emer Hughes, Maria Murgasova, Rui Pedro A G Teixeira, Johannes K Steinweg, Sagar Kulkarni, Loay Rahman, Hui Zhang, Daniel C Alexander, Kuberan Pushparajah, Daniel Rueckert, Joseph V Hajnal, John Simpson, A David Edwards, Mary A Rutherford, Serena J Counsell
Neurodevelopmental impairment is the most common comorbidity associated with complex congenital heart disease (CHD), while the underlying biological mechanism remains unclear. We hypothesised that impaired cerebral oxygen delivery in infants with CHD is a cause of impaired cortical development, and predicted that cardiac lesions most associated with reduced cerebral oxygen delivery would demonstrate the greatest impairment of cortical development. We compared 30 newborns with complex CHD prior to surgery and 30 age-matched healthy controls using brain MRI...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117954/blood-pressure-from-mid-to-late-life-and-risk-of-incident-dementia
#14
Emer R McGrath, Alexa S Beiser, Charles DeCarli, Kendra L Plourde, Ramachandran S Vasan, Steven M Greenberg, Sudha Seshadri
OBJECTIVE: To determine the association between blood pressure during midlife (40-64 years) to late life (≥65 years) and risk of incident dementia. METHODS: This study included 1,440 (758 women, mean age 69 ± 6 years) Framingham Offspring participants who were free of dementia and attended 5 consecutive examinations at 4-year intervals starting at midlife (1983-1987, mean age 55 years) until late life (1998-2001, mean 69 years) and subsequently were followed up for incident dementia (mean 8 years)...
November 8, 2017: Neurology
https://www.readbyqxmd.com/read/29100940/multimodal-surface-matching-with-higher-order-smoothness-constraints
#15
Emma C Robinson, Kara Garcia, Matthew F Glasser, Zhengdao Chen, Timothy S Coalson, Antonios Makropoulos, Jelena Bozek, Robert Wright, Andreas Schuh, Matthew Webster, Jana Hutter, Anthony Price, Lucilio Cordero Grande, Emer Hughes, Nora Tusor, Philip V Bayly, David C Van Essen, Stephen M Smith, A David Edwards, Joseph Hajnal, Mark Jenkinson, Ben Glocker, Daniel Rueckert
In brain imaging, accurate alignment of cortical surfaces is fundamental to the statistical sensitivity and spatial localisation of group studies; and cortical surface-based alignment has generally been accepted to be superior to volume-based approaches at aligning cortical areas. However, human subjects have considerable variation in cortical folding, and in the location of functional areas relative to these folds. This makes alignment of cortical areas a challenging problem. The Multimodal Surface Matching (MSM) tool is a flexible, spherical registration approach that enables accurate registration of surfaces based on a variety of different features...
October 31, 2017: NeuroImage
https://www.readbyqxmd.com/read/29099931/clinical-fractures-among-older-men-with-diabetes-are-mediated-by-diabetic-complications
#16
Richard H Lee, Richard Sloane, Carl Pieper, Kenneth W Lyles, Robert A Adler, Courtney Van Houtven, Joanne LaFleur, Cathleen Colón-Emeric
Introduction: Type 2 diabetes mellitus among older women has been associated with increased bone mineral density, but paradoxically increased fracture risk. Findings among older men have varied, and potential mechanisms have not been fully elucidated. Methods: Retrospective study of male Veterans 65-99 years of age who received primary care in the Veterans Health Administration (VHA) from 2000 to 2010, using administrative data from all 146 VHA medical centers linked to Centers for Medicare and Medicaid Services (CMS) Medicare fee-for-service data...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29093454/a-novel-peptide-that-improves-metabolic-parameters-without-adverse-central-nervous-system-effects
#17
Patrícia Reckziegel, William T Festuccia, Luiz R G Britto, Karen L Lopes Jang, Carolina M Romão, Joel C Heimann, Manoela V Fogaça, Naielly S Rodrigues, Nicole R Silva, Francisco S Guimarães, Rosangela A S Eichler, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Andrea S Heimann, Emer S Ferro
Intracellular peptides generated by limited proteolysis are likely to function inside and outside cells and could represent new possibilities for drug development. Here, we used several conformational-sensitive antibodies targeting G-protein coupled receptors to screen for novel pharmacological active peptides. We find that one of these peptides, DITADDEPLT activates cannabinoid type 1 receptors. Single amino acid modifications identified a novel peptide, DIIADDEPLT (Pep19), with slightly better inverse agonist activity at cannabinoid type 1 receptors...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29091950/generation-of-g-protein-coupled-receptor-antibodies-differentially-sensitive-to-conformational-states
#18
Andrea S Heimann, Achla Gupta, Ivone Gomes, Rahman Rayees, Avner Schlessinger, Emer S Ferro, Ellen M Unterwald, Lakshmi A Devi
The N-terminal region of G protein-coupled receptors can be efficiently targeted for the generation of receptor-selective antibodies. These antibodies are useful for the biochemical characterization of the receptors. In this study, we developed a set of criteria to select the optimal epitope and applied them to generate antibodies to the N-terminal region of 34 different G protein-coupled receptors. The antibody characterization revealed that a subset of antibodies exhibited increased recognition of the receptor following agonist treatment and this increase could be blocked by treatment with the receptor antagonist...
2017: PloS One
https://www.readbyqxmd.com/read/29056307/spinout-dislocation-in-mobile-bearing-total-knee-arthroplasty-a-report-of-26-cases
#19
Owen J Diamond, Emer Doran, David E Beverland
BACKGROUND: Excellent medium-term to long-term results for function and survivorship have been shown with mobile-bearing (MB) total knee arthroplasty (TKA). One of the key arguments against its use is the risk of "spinout" or dislocation of the MB. The aim of this study is to discuss the etiology, prevention, incidence, management, and outcome of spinout. METHODS: Between October 1993 and February 2016, 8373 consecutive primary MB TKAs were performed irrespective of preoperative deformity...
September 19, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29041514/nonlinear-polarization-instability-in-cubic-quintic-plasmonic-nanocomposites
#20
Albert S Reyna, Emeric Bergmann, Pierre-François Brevet, Cid B de Araújo
We report a study of the nonlinear birefringence induced in a metal-dielectric nanocomposite due to the contributions of third- and fifth-order optical nonlinearities. A theoretical model describing the evolution of the light polarization state of a confined laser beam propagating through the nonlinear medium is developed with basis on a pair of coupled dissipative cubic-quintic nonlinear differential equations related to the two orthogonal polarizations of the optical field. As a proof-of-principle experiment we demonstrate the control of the light beam polarization in a silver-nanocolloid by changing the silver nanoparticles volume fraction, f, and the light intensity...
September 4, 2017: Optics Express
keyword
keyword
2960
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"