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https://www.readbyqxmd.com/read/27929376/pharmaceutical-regulation-in-15-european-countries-review
#1
Dimitra Panteli, Francis Arickx, Irina Cleemput, Guillaume Dedet, Helen Eckhardt, Emer Fogarty, Sophie Gerkens, Cornelia Henschke, Jennifer Hislop, Claudio Jommi, Daphne Kaitelidou, Pawel Kawalec, Ilmo Keskimaki, Madelon Kroneman, Julio Lopez Bastida, Pedro Pita Barros, Joakim Ramsberg, Peter Schneider, Susan Spillane, Sabine Vogler, Lauri Vuorenkoski, Helle Wallach Kildemoes, Olivier Wouters, Reinhard Busse
In the context of pharmaceutical care, policy-makers repeatedly face the challenge of balancing patient access to effective medicines with affordability and rising costs. With the aim of guiding the health policy discourse towards questions that are important to actual and potential patients, this study investigates a broad range of regulatory measures, spanning marketing authorization to generic substitution and resulting price levels in a sample of 16 European health systems (Austria, Belgium, Denmark, England, Finland, France, Germany, Greece, Ireland, Italy, the Netherlands, Poland, Portugal, Scotland, Spain and Sweden)...
October 2016: Health Systems in Transition
https://www.readbyqxmd.com/read/27919409/physiotherapy-managers-perceptions-of-their-leadership-effectiveness-a-multi-frame-analysis
#2
Emer McGowan, Cathal Walsh, Emma Stokes
OBJECTIVES: The purpose of this study was to investigate the leadership frames of physiotherapy managers in Ireland. To be effective leaders in today's challenging healthcare environment physiotherapy managers must employ a comprehensive, adaptable and balanced leadership style. DESIGN: This was a purposive, cross-sectional study. PARTICIPANTS: Physiotherapy managers were surveyed using the Bolman and Deal Leadership Orientations Instrument...
July 18, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27909357/perceptions-of-leadership-comparing-canadian-and-irish-physiotherapists-views
#3
Emer McGowan, Gillian Martin, Emma Stokes
Purpose: To contribute to the growing body of research on leadership in physiotherapy by comparing leadership-related perceptions of physiotherapists in Ireland and in Canada. Methods: This article compares the results of a survey of Canadian physiotherapists with those of the same survey administered to Irish physiotherapists. The results of both studies have previously been reported and are used here to allow a cultural comparison of the perceptions of physiotherapists. The present study used two-portion Z-tests to compare the percentage of physiotherapists in Ireland who self-declared as a leader with the percentage of physiotherapists in Canada who did so...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27908391/prevalence-profile-and-prognosis-of-severe-obesity-in-contemporary-hospitalized-heart-failure-trial-populations
#4
Emer Joyce, Anuradha Lala, Susanna R Stevens, Lauren B Cooper, Omar F AbouEzzeddine, John D Groarke, Justin L Grodin, Eugene Braunwald, Kevin J Anstrom, Margaret M Redfield, Lynne W Stevenson
OBJECTIVES: This study evaluated the prevalence, profile, and prognosis of severe obesity in a large contemporary acute heart failure (AHF) population. BACKGROUND: Better prognosis has been reported for obese heart failure (HF) patients than nonobese HF patients, but in other cardiovascular populations, this effect has not been demonstrated for severely obese patients. METHODS: A cohort of 795 participants with body mass index (BMI) measured at time of admission and complete follow-up were identified from enrollment in 3 contemporary AHF trials (DOSE [Diuretic Strategies Optimization Evaluation], CARRESS-HF [Cardiorenal Rescue Study in Acute Decompensated Heart Failure], and ROSE [Renal Optimization Strategies Evaluation in Acute Heart Failure])...
December 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/27899144/hypoxia-induced-responses-by-endothelial-colony-forming-cells-are-modulated-by-placental-growth-factor
#5
Michelle B Hookham, Imran H A Ali, Christina L O'Neill, Emer Hackett, Melanie H Lambe, Tina Schmidt, Reinhold J Medina, Sara Chamney, Bharathi Rao, Eibhlin McLoone, David Sweet, Alan W Stitt, Derek P Brazil
BACKGROUND: Endothelial colony-forming cells (ECFCs), also termed late outgrowth endothelial cells, are a well-defined circulating endothelial progenitor cell type with an established role in vascular repair. ECFCs have clear potential for cell therapy to treat ischaemic disease, although the precise mechanism(s) underlying their response to hypoxia remains ill-defined. METHODS: In this study, we isolated ECFCs from umbilical cord blood and cultured them on collagen...
November 29, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27896505/focused-versus-bilateral-parathyroid-exploration-for-primary-hyperparathyroidism-a-systematic-review-and-meta-analysis
#6
Marcel Jinih, Emer O'Connell, Donal P O'Leary, Aaron Liew, Henry P Redmond
BACKGROUND: Focused exploration (FE) and bilateral parathyroid exploration (BE) are the standard surgical options for patients with primary hyperparathyroidism. However, the relative risk of recurrence, persistence, overall failure, reoperation, and any complications associated with either surgical approach is unclear. This study compared the outcomes and complication rates after FE and BE for patients with primary hyperparathyroidism. METHODS: PubMed and Embase were searched for studies comparing these outcomes between FE and BE...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27893011/cardiovascular-medications-and-fractures-dodging-complexity
#7
Cathleen S Colón-Emeric, Richard Lee
No abstract text is available yet for this article.
November 21, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27878525/genetics-of-frontotemporal-dementia
#8
REVIEW
Diana A Olszewska, Roisin Lonergan, Emer M Fallon, Tim Lynch
Frontotemporal dementia (FTD) is the second most common cause of dementia following Alzheimer's disease (AD). Between 20 and 50% of cases are familial. Mutations in MAPT, GRN and C9orf72 are found in 60% of familial FTD cases. C9orf72 mutations are the most common and account for 25%. Rarer mutations (<5%) occur in other genes such as VPC, CHMP2B, TARDP, FUS, ITM2B, TBK1 and TBP. The diagnosis is often challenging due to symptom overlap with AD and other conditions. We review the genetics, clinical presentations, neuroimaging, neuropathology, animal studies and therapeutic trials in FTD...
December 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27872974/interest-of-using-ropivacaine-for-outpatient-laparoscopic-cholecystectomy-prospective-randomized-trial
#9
Emeric Abet, François Orion, Fabrice Denimal, Anne-Géraldine Brau-Weber, Benoît de Kerviler, Marc-Henri Jean, Guillaume Boulanger, Jérôme Dimet, Michel Comy
BACKGROUND: The objective of this study was to evaluate the interest of using ropivacaine for outpatient laparoscopic cholecystectomy. The use of local anesthesia by instillation and infiltration could reduce pain and increase the number of outpatient cholecystectomies. METHODS: A one-center randomized prospective clinical trial compared the use of ropivacaine during outpatient laparoscopic cholecystectomy to the control group of outpatients for laparoscopic cholecystectomy between April 2014 and May 2015...
November 21, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27872229/clinical-reasoning-a-64-year-old-man-with-visual-distortions
#10
Emer R McGrath, Ayush Batra, Alice D Lam, Joseph F Rizzo, Andrew J Cole
No abstract text is available yet for this article.
November 22, 2016: Neurology
https://www.readbyqxmd.com/read/27871573/the-preoperative-use-of-field-tests-of-exercise-tolerance-to-predict-postoperative-outcome-in-intra-abdominal-surgery-a-systematic-review
#11
REVIEW
Jonathan Moran, Fiona Wilson, Emer Guinan, Paul McCormick, Juliette Hussey, Jeanne Moriarty
STUDY OBJECTIVE: To assess the ability of field tests of exercise tolerance, such as the 6-minute walk test (6MWT) and incremental shuttle walk test (ISWT), to predict postoperative outcome following intra-abdominal surgery. DESIGN: A systematic review. SETTING: A hospital-affiliated university. MEASUREMENTS: The following databases were searched: AMED, CINAHL, EMBASE, PEDro, PubMed/MEDLINE, and The Cochrane Library...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27843104/left-atrial-dysfunction-in-the-pathogenesis-of-cryptogenic-stroke-novel-insights-from-speckle-tracking-echocardiography
#12
Darryl P Leong, Emer Joyce, Philippe Debonnaire, Spyridon Katsanos, Eduard R Holman, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
BACKGROUND: Myocardial strain analysis by speckle-tracking echocardiography, which can detect subtle abnormalities in left atrial (LA) function, may offer unique insights into LA pathophysiology in patients with cryptogenic stroke (CS). The aim of this study was to investigate whether LA reservoir strain by speckle-tracking echocardiography, as a measure of LA compliance, is impaired in patients with CS and no history of atrial fibrillation. METHODS: A retrospective case-control study of 742 patients (mean age, 59 ± 13 years; 54% men; 371 with CS and 371 control subjects) was conducted...
November 11, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27826929/practical-bioinformatics-analysis-of-mirna-data-using-online-tools
#13
James A L Brown, Emer Bourke
The purpose of this chapter is to provide a starting point for the analysis of miRNA array data, using freely available online suites of tools. This chapter does not describe how to perform analysis of primary array data, rather how to use the top differentially regulated miRNA (returned from comparing one miRNA group to another) as the starting point for further practical analysis.Here we describe the methods and tools required to identify targets worthy of additional investigation, using the identified miRNA as a starting point...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27824959/risk-factors-and-stratification-for-recurrence-of-patients-with-differentiated-thyroid-cancer-elevated-thyroglobulin-and-negative-i-131-whole-body-scan-by-restaging-18-f-fdg-pet-ct
#14
Kursat Okuyucu, Semra Ince, Engin Alagoz, Ozdes Emer, Huseyin San, Elif Balkan, Aslı Ayan, Coskun Meric, Cem Haymana, Cengizhan Acıkel, Bengul Gunalp, Alper Ozgur Karacalioglu, Nuri Arslan
OBJECTIVE: In nearly 20%-30% of patients with differentiated thyroid carcinoma (DTC) relapse and 7% of them die during the next 10 years after initial diagnosis. In 10%-30% of patients with DTC after ablation therapy during the follow-up show a negative iodine-131 ((131)I) whole-body screening test ((131)I WBS) and increased serum thyroglobulin (Tg) level. Loss of ability of DTC metastatic lesions to trap (131)I is associated with pure survival and often aggressive disease. Several studies have shown that in DTC cases non trapping (131)I, fluorine-18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) can detect recurrence or metastases with high sensitivity (80%-90%)...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27807666/effects-of-a-multimodal-rehabilitation-programme-on-inflammation-and-oxidative-stress-in-oesophageal-cancer-survivors-the-restore-feasibility-study
#15
Emer M Guinan, Suzanne L Doyle, Linda O'Neill, Margaret R Dunne, Emma K Foley, Jacintha O'Sullivan, John V Reynolds, Juliette Hussey
PURPOSE: Physical, nutritional and quality-of-life compromises are known sequelae of oesophageal cancer (OC) treatment. Inflammation and oxidative stress may be relevant to adverse consequences. Multimodal rehabilitation involving exercise and diet prescription may attenuate some of the negative consequences and optimise survivorship, and this was assessed in this feasibility study in OC patients at least 1 year post-oesophagectomy. METHODS: The 12-week programme included supervised and home-based exercise, dietetic counselling to ensure energy balance and multidisciplinary education...
November 3, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27796857/turning-failure-into-success-trials-of-the-heart-failure-clinical-research-network
#16
REVIEW
Emer Joyce, Michael M Givertz
The Heart Failure Clinical Research Network (HFN) was established in 2008 on behalf of the NIH National Heart, Lung and Blood Institute, with the primary goal of improving outcomes in heart failure (HF) by designing and conducting high-quality concurrent clinical trials testing interventions across the spectrum of HF. Completed HFN trials have answered several important and relevant clinical questions concerning the safety and efficacy of different decongestive and adjunctive vasodilator therapies in hospitalized acute HF, phosphodiesterase-5 inhibition and nitrate therapies in HF with preserved ejection fraction, and the role of xanthine oxidase inhibition in hyperuricemic HF...
December 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27793473/analysis-of-the-prion-protein-gene-in-multiple-system-atrophy
#17
Viorica Chelban, Andreea Manole, Lasse Pihlstrøm, Lucia Schottlaender, Stephanie Efthymiou, Emer OConnor, Wassilios G Meissner, Janice L Holton, Henry Houlden
Neurodegenerative diseases are a very diverse group of disorders but they share some common mechanisms such as abnormally misfolded proteins with prion-like propagation and aggregation. Creutzfeldt-Jakob disease (CJD) is the most prevalent prion disease in humans. In the sporadic form of CJD the only known risk factor is the codon 129 polymorphism. Recent reports suggested that α-synuclein in multiple system atrophy (MSA) has similar pathogenic mechanisms as the prion protein. Here we present 1 Italian family with MSA and prion disease...
October 3, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27776111/complex-transcriptional-modulation-with-orthogonal-and-inducible-dcas9-regulators
#18
Yuchen Gao, Xin Xiong, Spencer Wong, Emeric J Charles, Wendell A Lim, Lei S Qi
The ability to dynamically manipulate the transcriptome is important for studying how gene networks direct cellular functions and how network perturbations cause disease. Nuclease-dead CRISPR-dCas9 transcriptional regulators, while offering an approach for controlling individual gene expression, remain incapable of dynamically coordinating complex transcriptional events. Here, we describe a flexible dCas9-based platform for chemical-inducible complex gene regulation. From a screen of chemical- and light-inducible dimerization systems, we identified two potent chemical inducers that mediate efficient gene activation and repression in mammalian cells...
October 24, 2016: Nature Methods
https://www.readbyqxmd.com/read/27747157/brain-transcriptomes-of-honey-bees-apis-mellifera-experimentally-infected-by-two-pathogens-black-queen-cell-virus-and-nosema-ceranae
#19
Vincent Doublet, Robert J Paxton, Cynthia M McDonnell, Emeric Dubois, Sabine Nidelet, Robin F A Moritz, Cédric Alaux, Yves Le Conte
Regulation of gene expression in the brain plays an important role in behavioral plasticity and decision making in response to external stimuli. However, both can be severely affected by environmental factors, such as parasites and pathogens. In honey bees, the emergence and re-emergence of pathogens and potential for pathogen co-infection and interaction have been suggested as major components that significantly impaired social behavior and survival. To understand how the honey bee is affected and responds to interacting pathogens, we co-infected workers with two prevalent pathogens of different nature, the positive single strand RNA virus Black queen cell virus (BQCV), and the Microsporidia Nosema ceranae, and explored gene expression changes in brains upon single infections and co-infections...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27739445/preclinical-validation-of-the-small-molecule-drug-quininib-as-a-novel-therapeutic-for-colorectal-cancer
#20
Adrian G Murphy, Rory Casey, Aoife Maguire, Miriam Tosetto, Clare T Butler, Emer Conroy, Alison L Reynolds, Kieran Sheahan, Diarmuid O'Donoghue, William M Gallagher, David Fennelly, Breandán N Kennedy, Jacintha O'Sullivan
Colorectal cancer (CRC) is a leading cause of cancer deaths. Molecularly targeted therapies (e.g. bevacizumab) have improved survival rates but drug resistance ultimately develops and newer therapies are required. We identified quininib as a small molecule drug with anti-angiogenic activity using in vitro, ex vivo and in vivo screening models. Quininib (2-[(E)-2-(Quinolin-2-yl) vinyl] phenol), is a small molecule drug (molecular weight 283.75 g/mol), which significantly inhibited blood vessel development in zebrafish embryos (p < 0...
October 14, 2016: Scientific Reports
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