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https://www.readbyqxmd.com/read/28435479/a-novel-program-for-absn-students-to-generate-interest-in-geriatrics-and-geriatric-nursing-research
#1
Jennifer Mewshaw, Donald E Bailey, Amber L Anderson, Ruth A Anderson, Andrew L Burd, Cathleen Colón-Emeric, Kirsten N Corazzini
The current shortage of nurse researchers in geriatrics adversely affects the capacity of nurses to conduct research to advance the evidence-based care of older adults. In an effort to generate interest in geriatrics and geriatric nursing research, the Duke University School of Nursing designed a summer internship for four students enrolled in the accelerated baccalaureate nursing (ABSN) program. This paper describes the experience of these ABSN students and the staff and faculty who worked with them. The program design, staff and faculty experiences, benefits and challenges, as well as recommendations for future programs are discussed...
2017: Journal of Nursing Education and Practice
https://www.readbyqxmd.com/read/28409899/genetic-variation-of-the-alpha-1-antitrypsin-gene-is-associated-with-increased-autoantibody-production-in-rheumatoid-arthritis
#2
Cormac McCarthy, Carl Orr, Laura Fee, Danielle M Dunlea, David J L Hunt, Eimear Dunne, Tomás P Carroll, Paul O'Connell, Geraldine McCarthy, Dermot Kenny, Ursula Fearon, Douglas J Veale, Emer P Reeves, Noel G McElvaney
OBJECTIVE: To examine the prevalence of alpha-1 antitrypsin (AAT) deficiency (AATD) in rheumatoid arthritis (RA), and to determine if AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANA) and anti-citrullinated peptide auto-antibodies (ACPA). METHODS: RF, ANA and ACPA were measured by standard immunoturbidimetry, immunofluorescence and ELISA, respectively. Characterisation of AAT phenotypes was performed by isoelectric focussing and immunofixation...
April 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28408243/erlotinib-and-bevacizumab-in-patients-with-advanced-non-small-cell-lung-cancer-and-activating-egfr-mutations-belief-an-international-multicentre-single-arm-phase-2-trial
#3
Rafael Rosell, Urania Dafni, Enriqueta Felip, Alessandra Curioni-Fontecedro, Oliver Gautschi, Solange Peters, Bartomeu Massutí, Ramon Palmero, Santiago Ponce Aix, Enric Carcereny, Martin Früh, Miklos Pless, Sanjay Popat, Athanasios Kotsakis, Sinead Cuffe, Paolo Bidoli, Adolfo Favaretto, Patrizia Froesch, Noemí Reguart, Javier Puente, Linda Coate, Fabrice Barlesi, Daniel Rauch, Michael Thomas, Carlos Camps, Jose Gómez-Codina, Margarita Majem, Rut Porta, Riyaz Shah, Emer Hanrahan, Roswitha Kammler, Barbara Ruepp, Manuela Rabaglio, Marie Kassapian, Niki Karachaliou, Rachel Tam, David S Shames, Miguel A Molina-Vila, Rolf A Stahel
BACKGROUND: The tyrosine kinase inhibitor erlotinib improves the outcomes of patients with advanced non-small-cell lung carcinoma (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations. The coexistence of the T790M resistance mutation with another EGFR mutation in treatment-naive patients has been associated with a shorter progression-free survival to EGFR inhibition than in the absence of the T790M mutation. To test this hypothesis clinically, we developed a proof-of-concept study, in which patients with EGFR-mutant NSCLC were treated with the combination of erlotinib and bevacizumab, stratified by the presence of the pretreatment T790M mutation...
April 10, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28408179/5-year-expression-and-neutrophil-defect-repair-after-gene-therapy-in-alpha-1-antitrypsin-deficiency
#4
Christian Mueller, Gwladys Gernoux, Alisha M Gruntman, Florie Borel, Emer P Reeves, Roberto Calcedo, Farshid N Rouhani, Anthony Yachnis, Margaret Humphries, Martha Campbell-Thompson, Louis Messina, Jeffrey D Chulay, Bruce Trapnell, James M Wilson, Noel G McElvaney, Terence R Flotte
Alpha-1 antitrypsin deficiency is a monogenic disorder resulting in emphysema due principally to the unopposed effects of neutrophil elastase. We previously reported achieving plasma wild-type alpha-1 antitrypsin concentrations at 2.5%-3.8% of the purported therapeutic level at 1 year after a single intramuscular administration of recombinant adeno-associated virus serotype 1 alpha-1 antitrypsin vector in alpha-1 antitrypsin deficient patients. We analyzed blood and muscle for alpha-1 antitrypsin expression and immune cell response...
April 10, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28396063/-morel-lavall%C3%A3-e-syndrome-and-post-traumatic-nodular-fat-necrosis-two-post-traumatic-complications-mimicking-cellulitis
#5
C Moulin, I Barthélémy, C Emering, M D'Incan
BACKGROUND: Dermal and subcutaneous inflammation following direct trauma is initially evocative of soft-tissue infection. However, two differential diagnoses must be considered: Morel-Lavallée syndrome and post-traumatic nodular fat necrosis. PATIENTS AND METHODS: Case 1: a 51-year-old woman fell off her motorbike and had dermabrasions on her right and left tibial ridges that rapidly developed into dermo-hypodermitis of the entire limb. There was no improvement after 3 weeks of antibiotics...
April 7, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28391289/sleep-to-lower-elevated-blood-pressure-a-randomized-controlled-trial-slept
#6
Emer R McGrath, Colin A Espie, Alice Power, Andrew W Murphy, John Newell, Caroline Kelly, Niamh Duffy, Patricia Gunning, Irene Gibson, Sophie Bostock, Martin J O'Donnell
BACKGROUND: Impaired sleep quality is common and associated with an increased risk of cardiovascular disease (CVD), thought to be mediated through adverse effects on established vascular risk factors, particularly hypertension. We determined if a web-delivered sleep intervention (sleep-hygiene education, stimulus control, and cognitive behavioral therapy) reduces blood pressure compared to vascular risk factor education (standard care) alone. METHODS: Phase II randomized, blinded, controlled trial of 134 participants without CVD with mild sleep impairment and blood pressure 130-160/<110 mm Hg...
March 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28383851/-toxic-epidermal-necrolysis-lyell-syndrome-a-lifethreatening-emergency-of-introgenic-origin
#7
REVIEW
G E Piérard, S Jennes, C Piérard-Franchimont
Cutaneous drug eruptions are frequently encoun¬tered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often suggestive of the dermatosis nature, and varies according to the type of drug reaction. Some drug eruptions follow a benign course, but others including the toxic epidermal necrolysis are severe and life-threatening. It corresponds to a dermatological emer¬gency to be managed in a specialized burn unit.
October 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28383311/musculoskeletal-pain-profile-of-obese-individuals-attending-a-multidisciplinary-weight-management-service
#8
Grace A MacLellan, Colin Dunlevy, Emer O'Malley, Catherine Blake, Cathy Breen, Karen Gaynor, Natalie Wallace, Ruth Yoder, Domhnall Casey, John Mehegan, Donal O'Shea, Brona M Fullen
Obesity is associated with numerous chronic diseases, including musculoskeletal (MSK) pain, which impacts on quality of life (QoL). There is, however, limited research providing a comprehensive MSK pain profile of an obese cohort. This retrospective study utilized a patient database at a national weight management service (WMS). Following ethical approval, anonymized patient data were statistically analyzed to develop a pain profile, investigate relationships between pain, sleep, and function, and explore variables associated with having low back pain (LBP) and knee pain...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28370710/probing-skin-physiology-through-the-volatile-footprint-discriminating-volatile-emissions-before-and-after-acute-barrier-disruption
#9
Emer Duffy, Matthew R Jacobs, Brian Kirby, Aoife Morrin
Volatile organic compounds emitted by human skin were sampled before and after acute barrier disruption of the volar forearm to investigate the significance of this approach to skin physiology research. A small wearable housing integrating a solid phase micro-extraction fibre permitting rapid enclosed headspace sampling of human skin volatiles is presented, enabling non-invasive sample collection in 15 minutes, in a comfortable wearable format. Gas chromatography-mass spectrometry was utilised to separate and identify the volatile metabolites...
March 31, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28358921/vector-free-intracellular-delivery-by-reversible-permeabilization
#10
Shirley O'Dea, Valeria Annibaldi, Louise Gallagher, Joanne Mulholland, Emer L Molloy, Conor J Breen, Jennifer L Gilbert, Darren S Martin, Michael Maguire, Fitz-Roy Curry
Despite advances in intracellular delivery technologies, efficient methods are still required that are vector-free, can address a wide range of cargo types and can be applied to cells that are difficult to transfect whilst maintaining cell viability. We have developed a novel vector-free method that uses reversible permeabilization to achieve rapid intracellular delivery of cargos with varying composition, properties and size. A permeabilizing delivery solution was developed that contains a low level of ethanol as the permeabilizing agent...
2017: PloS One
https://www.readbyqxmd.com/read/28337182/new-insights-into-the-anti-pathogenic-potential-of-lactococcus-garvieae-against-staphylococcus-aureus-based-on-rna-sequencing-profiling
#11
Pierre Delpech, Etienne Rifa, Graham Ball, Sabine Nidelet, Emeric Dubois, Geneviève Gagne, Marie-Christine Montel, Céline Delbès, Stéphanie Bornes
The bio-preservation potential of Lactococcus garvieae lies in its capacity to inhibit the growth of staphylococci, especially Staphylococcus aureus, in dairy products and in vitro. In vitro, inhibition is modulated by the level of aeration, owing to hydrogen peroxide (H2O2) production by L. garvieae under aeration. The S. aureus response to this inhibition has already been studied. However, the molecular mechanisms of L. garvieae underlying the antagonism against S. aureus have never been explored. This study provides evidence of the presence of another extracellular inhibition effector in vitro...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28334910/evaluating-pharmacist-input-into-the-pharmaceutical-care-of-patients-in-dispensing-medical-practices-in-remote-and-rural-areas-of-scotland
#12
Derek Stewart, Breda Anthony, Clare Morrison, Yvonne MacRae, Lucy Dixon, Emer Friel, Evelyn Yoong, Scott Cunningham, Katie MacLure
Background.: The Highlands and the Western Isles are the two most remote and rural areas of Scotland, with many medical practices in areas where pharmacies would not be viable. Recent regulations state that that dispensing medical practices in these areas must receive pharmacist support for patients who would benefit. Objective.: This study aimed to evaluate pilot services, which centred on the provision of patient centred pharmaceutical care. Methods...
March 8, 2017: Family Practice
https://www.readbyqxmd.com/read/28317110/atlantic-frugivory-a-plant-frugivore-interaction-dataset-for-the-atlantic-forest
#13
Carolina Bello, Mauro Galetti, Denise Montan, Marco A Pizo, Tatiane C Mariguela, Laurence Culot, Felipe Bufalo, Fabio Labecca, Felipe Pedrosa, Rafaela Constantini, Carine Emer, Wesley R Silva, Fernanda R da Silva, Otso Ovaskainen, Pedro Jordano
The dataset provided here includes 8320 frugivory interactions (records of pairwise interactions between plant and frugivore species) reported for the Atlantic Forest. The dataset includes interactions between 331 vertebrate species (232 birds, 90 mammals, five fishes, one amphibian and three reptiles) and 788 plant species. We also present information on traits directly related to the frugivory process (endozoochory), such as the size of fruits and seeds and the body mass and gape size of frugivores. Data were extracted from 166 published and unpublished sources spanning from 1961 to 2016...
March 19, 2017: Ecology
https://www.readbyqxmd.com/read/28253264/a-multistrain-approach-to-studying-the-mechanisms-underlying-compatibility-in-the-interaction-between-biomphalaria-glabrata-and-schistosoma-mansoni
#14
Richard Galinier, Emmanuel Roger, Yves Moné, David Duval, Anaïs Portet, Silvain Pinaud, Cristian Chaparro, Christoph Grunau, Clémence Genthon, Emeric Dubois, Anne Rognon, Nathalie Arancibia, Bernard Dejean, André Théron, Benjamin Gourbal, Guillaume Mitta
In recent decades, numerous studies have sought to better understand the mechanisms underlying the compatibility between Biomphalaria glabrata and Schistosoma mansoni. The developments of comparative transcriptomics, comparative genomics, interactomics and more targeted approaches have enabled researchers to identify a series of candidate genes. However, no molecular comparative work has yet been performed on multiple populations displaying different levels of compatibility. Here, we seek to fill this gap in the literature...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28252016/an-antimicrobial-peptide-resistant-minor-subpopulation-of-photorhabdus-luminescens-is-responsible-for-virulence
#15
Annabelle Mouammine, Sylvie Pages, Anne Lanois, Sophie Gaudriault, Gregory Jubelin, Maurine Bonabaud, Stéphane Cruveiller, Emeric Dubois, David Roche, Ludovic Legrand, Julien Brillard, Alain Givaudan
Some of the bacterial cells in isogenic populations behave differently from others. We describe here how a new type of phenotypic heterogeneity relating to resistance to cationic antimicrobial peptides (CAMPs) is determinant for the pathogenic infection process of the entomopathogenic bacterium Photorhabdus luminescens. We demonstrate that the resistant subpopulation, which accounts for only 0.5% of the wild-type population, causes septicemia in insects. Bacterial heterogeneity is driven by the PhoPQ two-component regulatory system and expression of pbgPE, an operon encoding proteins involved in lipopolysaccharide (LPS) modifications...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28247111/prospective-review-of-30-day-morbidity-and-mortality-in-a-paediatric-neurosurgical-unit
#16
REVIEW
Emer Campbell, Thomas Beez, Lorraine Todd
PURPOSE: The purpose of this study is to record the 30-day and inpatient morbidity and mortality in paediatric patients in a tertiary neuroscience centre over a 2-year period. The intentions were to establish the frequency of significant adverse events, review the current published rates of morbidity in paediatric neurosurgical patients and propose three clinical indicators for future comparison. METHODS: All deaths and adverse events were prospectively recorded from 1 January 2014 to 31 December 2015...
March 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28238475/mesorhizobium-delmotii-and-mesorhizobium-prunaredense-are-two-new-species-containing-rhizobial-strains-within-the-symbiovar-anthyllidis
#17
Roba Mohamad, Anne Willems, Antoine Le Quéré, Géraldine Maynaud, Marjorie Pervent, Maurine Bonabaud, Emeric Dubois, Jean-Claude Cleyet-Marel, Brigitte Brunel
Eight mesorhizobial symbiotic strains isolated from Anthyllis vulneraria root-nodules were studied and compared taxonomically with defined Mesorhizobium species. All strains presented identical 16S rDNA sequences but can be differentiated by multilocus sequence analysis of housekeeping genes (recA, atpD, glnII and dnaK). Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry analyses separate these strains in two groups and a separate strain. Levels of DNA-DNA relatedness were less than 55% between representative strains and their closest Mesorhizobium reference relatives...
February 12, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28236296/different-types-of-dietary-advice-for-women-with-gestational-diabetes-mellitus
#18
REVIEW
Shanshan Han, Philippa Middleton, Emily Shepherd, Emer Van Ryswyk, Caroline A Crowther
BACKGROUND: Dietary advice is the main strategy for managing gestational diabetes mellitus (GDM). It remains unclear what type of advice is best. OBJECTIVES: To assess the effects of different types of dietary advice for women with GDM for improving health outcomes for women and babies. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (8 March 2016), PSANZ's Trials Registry (22 March 2016) and reference lists of retrieved studies...
February 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28193762/teaching-neuroimages-ocular-findings-in-a-patient-with-wilson-disease-and-venous-sinus-thrombosis
#19
Ivana Vodopivec, Emer McGrath, Henrikas Vaitkevicius
No abstract text is available yet for this article.
February 14, 2017: Neurology
https://www.readbyqxmd.com/read/28186618/study-of-individualization-and-bias-in-nursing-home-fall-prevention-practices
#20
Cathleen S Colón-Emeric, Kirsten Corazzini, Eleanor McConnell, Wei Pan, Mark Toles, Rasheeda Hall, Melissa Batchelor-Murphy, Tracey L Yap, Amber L Anderson, Andrew Burd, Ruth A Anderson
OBJECTIVES: Little is known about how nursing home staff use resident characteristics to individualize care delivery or whether care is affected by implicit bias. DESIGN: Randomized factorial clinical vignette survey. SETTING: Sixteen nursing homes in North Carolina. PARTICIPANTS: Nursing, rehabilitation, and social services staff (n = 433). MEASUREMENTS: Vignettes describing hypothetical residents were generated from a matrix of clinical and demographic characteristics...
April 2017: Journal of the American Geriatrics Society
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