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https://www.readbyqxmd.com/read/28639024/nematicidal-potential-of-hydrolates-from-the-semi-industrial-vapor-pressure-extraction-of-spanish-aromatic-plants
#1
Maria Fe Andrés, Azucena González-Coloma, Ruben Muñoz, Felipe De la Peña, Luis Fernando Julio, Jesus Burillo
The nematicidal activity of hydrolate by-products from the semi industrial vapor-pressure essential oil extraction of selected aromatic plant species (commercial: Lavandula × intermedia Emeric ex Loisel. var. super, Thymus vulgaris L., T. zygis Loefl ex L. and experimentally pre-domesticated: L. luisieri (Rozeira) Rivas-Martínez) was investigated against the root-knot nematode Meloidogyne javanica by in vitro and in vivo bioassays. Liquid-liquid extraction of hydrolates yielded the corresponding aqueous and organic fractions which were biological and chemically studied...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28626962/three-dimensional-motion-corrected-sensitivity-encoding-reconstruction-for-multi-shot-multi-slice-mri-application-to-neonatal-brain-imaging
#2
Lucilio Cordero-Grande, Emer J Hughes, Jana Hutter, Anthony N Price, Joseph V Hajnal
PURPOSE: To introduce a methodology for the reconstruction of multi-shot, multi-slice magnetic resonance imaging able to cope with both within-plane and through-plane rigid motion and to describe its application in structural brain imaging. THEORY AND METHODS: The method alternates between motion estimation and reconstruction using a common objective function for both. Estimates of three-dimensional motion states for each shot and slice are gradually refined by improving on the fit of current reconstructions to the partial k-space information from multiple coils...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28608467/discourses-of-joint-commissioning
#3
Ailsa Cameron, Emer Brangan, John Gabbay, Jonathan H Klein, Catherine Pope, Lesley Wye
Increasing attention has focused on the role of joint commissioning in health and social care policy and practice in England. This paper provides an empirical examination of the three discourses of joint commissioning developed from an interpretative analysis of documents by Dickinson et al. (2013; BMC Health Services Research, 13) and applied to data from our study exploring the role of knowledge in commissioning in England. Based on interviews with 92 participants undertaken between 2011 and 2013, our analysis confirms that the three discourses of prevention or empowerment or efficiency are used by professionals from across health and social care organisations to frame their experiences of joint commissioning...
June 12, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28596280/extracellular-vesicles-of-bone-marrow-stromal-cells-rescue-chronic-lymphocytic-leukemia-b-cells-from-apoptosis-enhance-their-migration-and-induce-gene-expression-modifications
#4
Emerence Crompot, Michael Van Damme, Karlien Pieters, Marjorie Vermeersch, David Perez-Morga, Philippe Mineur, Marie Maerevoet, Nathalie Meuleman, Dominique Bron, Laurence Lagneaux, Basile Stamatopoulos
Interactions between chronic lymphocytic leukemia B-cells and the bone marrow microenvironment play a major function in the physiopathology of chronic lymphocytic leukemia. Extracellular vesicles, which are composed of exosomes and microparticles, play an important role in cell communication. However, little is known about their role in chronic lymphocytic leukemia/microenvironment interactions. In the present study, extracellular vesicles purified by ultracentrifugation from bone marrow mesenchymal stromal cell cultures were added to chronic lymphocytic leukemia B-cells...
June 8, 2017: Haematologica
https://www.readbyqxmd.com/read/28588282/comparison-and-immunobiological-characterization-of-retinoic-acid-inducible-gene-i-like-receptor-expression-in-mesenchymal-stromal-cells
#5
Gordana Raicevic, Mehdi Najar, Hélène Busser, Emerence Crompot, Dominique Bron, Michel Toungouz, Laurence Lagneaux
Due to their immunomodulatory and regenerative properties, Mesenchymal stromal cells (MSC) have generated major interests in several clinical settings including transplantation and inflammatory diseases. MSC functions can be influenced by their tissue origin. Their microenvironment strongly affects their biology notably through TLR sensing. In this study, we show that MSC isolated from four different sources express another type of cytosolic pathogen recognition receptors known as retinoic acid inducible gene-I (RIG-I)-like receptors (RLR)...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28567160/the-introduction-of-a-multidisciplinary-hip-fracture-pathway-to-optimise-patient-care-and-reduce-mortality-a-prospective-audit-of-161-patients
#6
Michael Shenouda, Zacharia Silk, Sarkhell Radha, Emer Bouanem, Warwick Radford
INTRODUCTION: Hip fractures are a major cause of morbidity and mortality in the elderly. A new patient pathway was introduced in our institution to facilitate rapid preoperative assessment, acute physician involvement and early surgery for patients with hip fractures. We sought to assess its impact on patient care and outcomes. MATERIALS AND METHODS: Prospective audit of 161 patients admitted with a proximal femoral fracture in the six months before (92 patients) and after (69 patients) implementation of the pathway...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28559461/the-hgf-c-met-pathway-is-a-driver-and-biomarker-of-vegfr-inhibitor-resistance-and-vascular-remodeling-in-non-small-cell-lung-cancer
#7
Tina Cascone, Li Xu, Heather Y Lin, Wenbin Liu, Hai T Tran, Yuan Liu, Kathryn J Howells, Vincent Haddad, Emer O Hanrahan, Monique Nilsson, Maria Angelica Cortez, Uma Giri, Humam Kadara, Babita Saigal, Yun-Yong Park, Weiyi Peng, Ju-Seog Lee, Anderson J Ryan, Juliane M Juergensmeier, Roy S Herbst, Jing Wang, Robert R Langley, Ignacio I Wistuba, J Jack Lee, John Heymach
Resistance to vascular endothelial growth factor receptor (VEGFR) inhibitors is a major obstacle in the treatment of non-small cell lung cancer (NSCLC). We investigated the cellular mechanisms mediating resistance of NSCLCs to VEGFR tyrosine kinase inhibitors.<br /><br />Experimental Design: We generated murine models of human NSCLC and performed targeted inhibition studies with the VEGFR TKIs cediranib and vandetanib. We used species-specific hybridization of microarrays to compare cancer (human) and stromal (mouse) cell transcriptomes of TKI-sensitive and -resistant tumors...
May 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28557055/time-efficient-and-flexible-design-of-optimized-multishell-hardi-diffusion
#8
Jana Hutter, J Donald Tournier, Anthony N Price, Lucilio Cordero-Grande, Emer J Hughes, Shaihan Malik, Johannes Steinweg, Matteo Bastiani, Stamatios N Sotiropoulos, Saad Jbabdi, Jesper Andersson, A David Edwards, Joseph V Hajnal
PURPOSE: Advanced diffusion magnetic resonance imaging benefits from collecting as much data as is feasible but is highly sensitive to subject motion and the risk of data loss increases with longer acquisition times. Our purpose was to create a maximally time-efficient and flexible diffusion acquisition capability with built-in robustness to partially acquired or interrupted scans. Our framework has been developed for the developing Human Connectome Project, but different application domains are equally possible...
May 30, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28551664/antibiotic-use-does-not-appear-to-influence-response-to-nivolumab
#9
Coureche Kaderbhai, Corentin Richard, Jean David Fumet, Anne Aarnink, Pascal Foucher, Bruno Coudert, Laure Favier, Aurélie Lagrange, Emeric Limagne, Romain Boidot, Francois Ghiringhelli
BACKGROUND: Microbiota is known to influence response to anticancer immunotherapy. We examined whether antibiotic usage could impact nivolumab efficacy in patients treated for non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Seventy-four patients with NSCLC were included in this retrospective study. They received nivolumab between 2015 and 2016 (3 mg/kg i.v. q2w). The association between RECIST response and antibiotic usage was determined using Chi-square and Cox proportional hazard model...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28548849/derisking-the-cu-mediated-18-f-fluorination-of-heterocyclic-positron-emission-tomography-radioligands
#10
Nicholas J Taylor, Enrico Emer, Sean Preshlock, Michael Schedler, Matthew Tredwell, Stefan Verhoog, Joel Mercier, Christophe Genicot, Véronique Gouverneur
Molecules labeled with fluorine-18 ((18)F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of (18)F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated (18)F-fluorination of aryl boron reagents with (18)F-fluoride as a model reaction...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28531240/public-knowledge-and-understanding-of-dementia-evidence-from-a-national-survey-in-ireland
#11
Ronan W Glynn, Emer Shelley, Brian A Lawlor
Background: there is growing consensus around the importance of population level approaches which seek to improve public knowledge and awareness of dementia. Aim: to assess knowledge of the relationship between dementia and ageing, and of the risk and protective factors associated with it, among the general public in Ireland. Design: cross-sectional survey. Participants selected using quota sampling based on Census data. Methods: the final sample of 1,217 respondents provided estimates of dementia knowledge in the Irish population...
May 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28524463/allograft-steatosis-in-the-midst-of-the-epidemic-of-obesity-are-children-in-the-honeymoon-period
#12
EDITORIAL
Emer Fitzpatrick, Maesha Deheragoda, Anil Dhawan
No abstract text is available yet for this article.
July 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28522655/choice-of-hemodialysis-access-in-older-adults-a-cost-effectiveness-analysis
#13
Rasheeda K Hall, Evan R Myers, Sylvia E Rosas, Ann M O'Hare, Cathleen S Colón-Emeric
BACKGROUND AND OBJECTIVES: Although arteriovenous fistulas have been found to be the most cost-effective form of hemodialysis access, the relative benefits of placing an arteriovenous fistula versus an arteriovenous graft seem to be least certain for older adults and when placed preemptively. However, older adults' life expectancy is heterogeneous, and most patients do not undergo permanent access creation until after dialysis initiation. We evaluated cost-effectiveness of arteriovenous fistula placement after dialysis initiation in older adults as a function of age and life expectancy...
June 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28515419/new-insights-into-ocean-sunfish-mola-mola-abundance-and-seasonal-distribution-in-the-northeast-atlantic
#14
Patricia Breen, Ana Cañadas, Oliver Ó Cadhla, Mick Mackey, Meike Scheidat, Steve C V Geelhoed, Emer Rogan, Mark Jessopp
The ocean sunfish, Mola mola, is the largest teleost fish in the world. Despite being found in all oceans of the world, little is known about its abundance and factors driving its distribution. In this study we provide the first abundance estimates for sunfish in offshore waters in the northeast Atlantic and the first record of extensive sunfish presence in these waters year-round. Abundance estimates and predictive distributions for sunfish in approximately 300,000 km² of the northeast Atlantic were derived from large scale offshore aerial surveys in 2015-2016 using distance sampling techniques...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489673/systematic-review-nutrition-and-physical-activity-in-the-management-of-paediatric-non-alcoholic-fatty-liver-disease
#15
Philippa S Gibson, Sarah Lang, Anil Dhawan, Emer Fitzpatrick, Michelle L Blumfield, Helen Truby, Kathryn H Hart, J Bernadette Moore
OBJECTIVES: To evaluate efficacy of nutrition and physical activity interventions in the clinical management of paediatric non-alcoholic fatty liver disease (NAFLD). The prevalence of paediatric NAFLD continues to rise alongside childhood obesity. Weight loss through lifestyle modification is currently first-line treatment, although supplementation of specific dietary components may be beneficial. METHODS: Medline, CINAHL, EMBASE, Scopus and Cochrane Libraries were systematically searched to identify randomised controlled trials (RCTs) assessing nutritional and physical activity interventions...
May 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28473509/why-do-patients-seek-primary-medical-care-in-emergency-departments-an-ethnographic-exploration-of-access-to-general-practice
#16
Fiona MacKichan, Emer Brangan, Lesley Wye, Kath Checkland, Daniel Lasserson, Alyson Huntley, Richard Morris, Peter Tammes, Chris Salisbury, Sarah Purdy
OBJECTIVES: To describe how processes of primary care access influence decisions to seek help at the emergency department (ED). DESIGN: Ethnographic case study combining non-participant observation, informal and formal interviewing. SETTING: Six general practitioner (GP) practices located in three commissioning organisations in England. PARTICIPANTS AND METHODS: Reception areas at each practice were observed over the course of a working week (73 hours in total)...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28461582/media-and-book-reviews-clinical-neurology-and-neuroanatomy-a-localization-based-approach
#17
Emer R McGrath
No abstract text is available yet for this article.
May 2, 2017: Neurology
https://www.readbyqxmd.com/read/28457976/a-tract-specific-approach-to-assessing-white-matter-in-preterm-infants
#18
Diliana Pecheva, Paul Yushkevich, Dafnis Batalle, Emer Hughes, Paul Aljabar, Julia Wurie, Joseph V Hajnal, A David Edwards, Daniel C Alexander, Serena J Counsell, Hui Zhang
Diffusion-weighted imaging (DWI) is becoming an increasingly important tool for studying brain development. DWI analyses relying on manually-drawn regions of interest and tractography using manually-placed waypoints are considered to provide the most accurate characterisation of the underlying brain structure. However, these methods are labour-intensive and become impractical for studies with large cohorts and numerous white matter (WM) tracts. Tract-specific analysis (TSA) is an alternative WM analysis method applicable to large-scale studies that offers potential benefits...
April 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28455421/therapeutic-rationale-to-target-highly-expressed-cdk7-conferring-poor-outcomes-in-triple-negative-breast-cancer
#19
Bo Li, Triona Ní Chonghaile, Yue Fan, Stephen Madden, Rut Klinger, Aisling E O'Connor, Louise Walsh, Gillian O'Hurley, Girish Mallya Udupi, Jesuchristopher Joseph, Finbarr Tarrant, Emer Conroy, Alexander Gaber, Suet-Feung Chin, Helen A Bardwell, Elena Provenzano, John Crown, Thierry Dubois, Sabine C Linn, Karin Jirstrom, Carlos Caldas, Darran O'Connor, William M Gallagher
Triple-negative breast cancer (TNBC) patients commonly exhibit poor prognosis and high relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies for this disease. Here, we report evidence highlighting the cell cycle-related kinase CDK7 as a driver and candidate therapeutic target in TNBC. Using publicly available transcriptomic data from a collated set of TNBC patients (n = 383) and the METABRIC TNBC dataset (n = 217), we found CDK7 mRNA levels to be correlated with patient prognosis...
April 28, 2017: Cancer Research
https://www.readbyqxmd.com/read/28450993/cd4-cells-recovery-in-hiv-positive-patients-with-severe-immunosuppression-at-haart-initiation-at-centre-medico-social-cor-unum-kigali
#20
Nyiramana Marie Merci, Uwimana Emerence, Nzitakera Augustin, Michael Habtu, Ingabire Julie, Tuyishime Angelique, Beneyo Jessica, Akimana Cynthia, Augustin Twizerimana Penda
INTRODUCTION: Up to 30% of HIV infected patients who are receiving HAART do not exhibit a marked increase in the CD4+ T cell count. There is still a concern that immune recovery may not be complete once CD4+ T cells have decreased below 200 cells/μl. The objective is to assess CD4+ cell recovery in HIV+ patients with CD4 count below 200 cells/μl) at HAART initiation. METHODS: This was a retrospective cohort study among 110 HIV+ patients with initial CD4 count < 200 cells/μl...
2017: Pan African Medical Journal
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