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https://www.readbyqxmd.com/read/29915428/a-precision-oncology-approach-to-the-pharmacological-targeting-of-mechanistic-dependencies-in-neuroendocrine-tumors
#1
Mariano J Alvarez, Prem S Subramaniam, Laura H Tang, Adina Grunn, Mahalaxmi Aburi, Gabrielle Rieckhof, Elena V Komissarova, Elizabeth A Hagan, Lisa Bodei, Paul A Clemons, Filemon S Dela Cruz, Deepti Dhall, Daniel Diolaiti, Douglas A Fraker, Afshin Ghavami, Daniel Kaemmerer, Charles Karan, Mark Kidd, Kyoung M Kim, Hee C Kim, Lakshmi P Kunju, Ülo Langel, Zhong Li, Jeeyun Lee, Hai Li, Virginia LiVolsi, Roswitha Pfragner, Allison R Rainey, Ronald B Realubit, Helen Remotti, Jakob Regberg, Robert Roses, Anil Rustgi, Antonia R Sepulveda, Stefano Serra, Chanjuan Shi, Xiaopu Yuan, Massimo Barberis, Roberto Bergamaschi, Arul M Chinnaiyan, Tony Detre, Shereen Ezzat, Andrea Frilling, Merten Hommann, Dirk Jaeger, Michelle K Kim, Beatrice S Knudsen, Andrew L Kung, Emer Leahy, David C Metz, Jeffrey W Milsom, Young S Park, Diane Reidy-Lagunes, Stuart Schreiber, Kay Washington, Bertram Wiedenmann, Irvin Modlin, Andrea Califano
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their ability to invert the concerted activity of master regulator proteins that mechanistically regulate tumor cell state, as assessed from systematic drug perturbation assays. We validated the approach on a cohort of 212 gastroenteropancreatic neuroendocrine tumors (GEP-NETs), a rare malignancy originating in the pancreas and gastrointestinal tract...
June 18, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29907406/first-spot-urine-sodium-after-initial-diuretic-identifies-patients-at-high-risk-for-adverse-outcome-after-heart-failure-hospitalization
#2
Adriana Luk, John D Groarke, Akshay S Desai, Syed Saad Mahmood, Deepa M Gopal, Emer Joyce, Sachin P Shah, Joann Lindenfeld, Lynne Stevenson, Neal K Lakdawala
BACKGROUND: Relief of congestion is the primary goal of initial therapy for acute decompensated heart failure (ADHF). Early measurement of urine sodium concentration (UNa) may be useful to identify patients with diminished response to diuretics. The aim of this study was to determine if the first spot UNa after diuretic initiation could select patients likely to require more intensive therapy during hospitalization. METHODS: At the time of admission, 103 patients with ADHF were identified prospectively, and UNa was measured after the first dose of intravenous diuretic...
May 19, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29898047/paradoxical-aortic-stenosis-simplifying-the-diagnostic-process
#3
Vitor Emer Egypto Rosa, João Ricardo Cordeiro Fernandes, Antonio Sergio de Santis Andrade Lopes, Roney Orismar Sampaio, Flávio Tarasoutchi
No abstract text is available yet for this article.
May 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29893487/prospective-assessment-of-combined-handgrip-strength-and-mini-cog-identifies-hospitalized-heart-failure-patients-at-increased-post-hospitalization-risk
#4
Emer Joyce, Erik H Howell, Alpana Senapati, Randall C Starling, Eiran Z Gorodeski
AIMS: The utility of combined assessment of both frailty and cognitive impairment in hospitalized heart failure (HF) patients for incremental post-discharge risk stratification, using handgrip strength and Mini-Cog as feasible representative parameters, was investigated. METHODS AND RESULTS: A prospective, single-centre cohort study of older adults (age ≥65) hospitalized for HF being discharged to home was performed. Pre-discharge, grip strength was assessed using a dynamometer (Jamar hydrolic hand dynamometer, Lafayette Instruments, Lafayette, IN, USA) and was defined as weak if the maximal value was below the gender-derived and body mass index-derived cut-offs according to Fried criteria...
June 12, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29890325/construction-of-a-neonatal-cortical-surface-atlas-using-multimodal-surface-matching-in-the-developing-human-connectome-project
#5
Jelena Bozek, Antonios Makropoulos, Andreas Schuh, Sean Fitzgibbon, Robert Wright, Matthew F Glasser, Timothy S Coalson, Jonathan O'Muircheartaigh, Jana Hutter, Anthony N Price, Lucilio Cordero-Grande, Rui Pedro A G Teixeira, Emer Hughes, Nora Tusor, Kelly Pegoretti Baruteau, Mary A Rutherford, A David Edwards, Joseph V Hajnal, Stephen M Smith, Daniel Rueckert, Mark Jenkinson, Emma C Robinson
We propose a method for constructing a spatio-temporal cortical surface atlas of neonatal brains aged between 36 and 44 weeks of post-menstrual age (PMA) at the time of scan. The data were acquired as part of the Developing Human Connectome Project (dHCP), and the constructed surface atlases are publicly available. The method is based on a spherical registration approach: Multimodal Surface Matching (MSM), using cortical folding for driving the alignment. Templates have been generated for the anatomical cortical surface and for the cortical feature maps: sulcal depth, curvature, thickness, T1w/T2w myelin maps and cortical regions...
June 9, 2018: NeuroImage
https://www.readbyqxmd.com/read/29874883/using-co-design-to-develop-a-collective-leadership-intervention-for-healthcare-teams-to-improve-safety-culture
#6
Marie E Ward, Aoife De Brún, Deirdre Beirne, Clare Conway, Una Cunningham, Alan English, John Fitzsimons, Eileen Furlong, Yvonne Kane, Alan Kelly, Sinéad McDonnell, Sinead McGinley, Brenda Monaghan, Ann Myler, Emer Nolan, Róisín O'Donovan, Marie O'Shea, Arwa Shuhaiber, Eilish McAuliffe
While co-design methods are becoming more popular in healthcare; there is a gap within the peer-reviewed literature on how to do co-design in practice. This paper addresses this gap by delineating the approach taken in the co-design of a collective leadership intervention to improve healthcare team performance and patient safety culture. Over the course of six workshops healthcare staff, patient representatives and advocates, and health systems researchers collaboratively co-designed the intervention. The inputs to the process, exercises and activities that took place during the workshops and the outputs of the workshops are described...
June 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29864608/comparison-of-epicardial-adipose-tissue-radiodensity-threshold-between-contrast-and-non-contrast-enhanced-computed-tomography-scans-a-cohort-study-of-derivation-and-validation
#7
Lingyu Xu, Yuancheng Xu, Richard Coulden, Emer Sonnex, Stanislau Hrybouski, Ian Paterson, Craig Butler
BACKGROUND AND AIMS: Epicardial adipose tissue (EAT) volume derived from contrast enhanced (CE) computed tomography (CT) scans is not well validated. We aim to establish a reliable threshold to accurately quantify EAT volume from CE datasets. METHODS: We analyzed EAT volume on paired non-contrast (NC) and CE datasets from 25 patients to derive appropriate Hounsfield (HU) cutpoints to equalize two EAT volume estimates. The gold standard threshold (-190HU, -30HU) was used to assess EAT volume on NC datasets...
May 11, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29862989/composite-laser-pulses-spectroscopy-for-high-accuracy-optical-clocks-a-review-of-recent-progress-and-perspectives
#8
Thomas Zanon-Willette, Remi Lefevre, Rémi Metzdorff, Nicolas Sillitoe, Sylvain Almonacil, Marco Minissale, Emeric de Clercq, Alexey V Taichevachev, Vareriy I Yudin, Ennio Arimondo
Probing an atomic resonance without disturbing it is an ubiquitous issue in physics. This problem is critical in
 high-accuracy spectroscopy or for the next generation of atomic optical clocks. Ultra-high
 resolution frequency metrology requires sophisticated interrogation schemes and robust protocols handling pulse length errors and residual frequency detuning offsets .
 This review reports recent progress and perspective in such schemes, using sequences of composite laser-pulses
 tailored in pulse duration, frequency and phase, inspired by NMR techniques and quantum information processing...
June 4, 2018: Reports on Progress in Physics
https://www.readbyqxmd.com/read/29862972/antipsychotic-induced-rhabdomyolysis
#9
Caroline Ratnam, Emeric Saguin, Symphonie Keou, Julie Plantamura, Coralie Mennessier, Bertrand Lahutte, Hervé Delacour
We report the case of a 40-year-old patient followed for post-traumatic stress disorder. A re-evaluation of its pharmacological treatment with the introduction of mirtazapine (30 mg/day) was associated with a rhabdomyolysis (CK> 20,000 IU/L at day 3). The diagnosis of mirtazapine induced rhabdomyolysis was made. After withdrawal of this drug combined with a symptomatic treatment (hydratation), the patient recovered well and was discharged without any nephrological sequelae. This article is intended to underline the diagnostic approach to elevated CK activity and the potential role of the "medical biologist" as a consultant for the relevant use of biological examinations...
June 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29852283/automated-processing-pipeline-for-neonatal-diffusion-mri-in-the-developing-human-connectome-project
#10
REVIEW
Matteo Bastiani, Jesper Andersson, Lucilio Cordero-Grande, Maria Murgasova, Jana Hutter, Anthony N Price, Antonios Makropoulos, Sean P Fitzgibbon, Emer Hughes, Daniel Rueckert, Suresh Victor, Mary Rutherford, A David Edwards, Steve Smith, Jacques-Donald Tournier, Joseph V Hajnal, Saad Jbabdi, Stamatios N Sotiropoulos
The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic and environmental influences on brain development, and the relation between connectivity and neurocognitive function. A large set of multi-modal MRI data from fetuses and newborn infants is currently being acquired, along with genetic, clinical and developmental information...
May 28, 2018: NeuroImage
https://www.readbyqxmd.com/read/29806711/the-role-of-ano1-in-mediating-cholinergic-neurotransmission-in-the-murine-gastric-fundus
#11
Tamara L McErlain, Emer P Ni Bhraonain, Rowena T Seaton Kelly
No abstract text is available yet for this article.
May 28, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29802969/different-patterns-of-cortical-maturation-before-and-after-38-weeks-gestational-age-demonstrated-by-diffusion-mri-in-vivo
#12
REVIEW
Dafnis Batalle, Jonathan O'Muircheartaigh, Antonios Makropoulos, Christopher J Kelly, Ralica Dimitrova, Emer J Hughes, Joseph V Hajnal, Hui Zhang, Daniel C Alexander, A David Edwards, Serena J Counsell
Human cortical development during the third trimester is characterised by macro- and microstructural changes which are reflected in alterations in diffusion MRI (dMRI) measures, with significant decreases in cortical mean diffusivity (MD) and fractional anisotropy (FA). This has been interpreted as reflecting increased cellular density and dendritic arborisation. However, the fall in FA stops abruptly at 38 weeks post-menstrual age (PMA), and then tends to plateau, while MD continues to fall, suggesting a more complex picture and raising the hypothesis that after this age development is dominated by continuing increase in neural and organelle density rather than alterations in the geometry of dendritic trees...
May 23, 2018: NeuroImage
https://www.readbyqxmd.com/read/29802135/a-rare-complication-of-ventriculoperitoneal-shunt-in-a-neonate
#13
Sandy Kirolos, Emer Campbell, Anne Marie Heuchan, Mairi Steven, Ruth Allen
No abstract text is available yet for this article.
May 25, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29796931/physical-decline-and-its-implications-in-the-management-of-oesophageal-and-gastric-cancer-a-systematic-review
#14
REVIEW
Linda O'Neill, Jonathan Moran, Emer M Guinan, John V Reynolds, Juliette Hussey
PURPOSE: The management of oesophageal and gastric cancer can cause significant physical decline, impacting on completion rates and outcomes. This systematic review aimed to (i) determine the impact of chemotherapy, chemoradiotherapy and surgery on physical function; (ii) identify associations between physical function and post-operative outcomes; and (iii) examine the effects of rehabilitation on physical function. METHODS: We included randomised controlled trials (RCT), non-RCTs of interventions and cohort studies that measured physical function by objective means in patients with oesophageal or gastric cancer...
May 23, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29788088/report-nia-workshop-on-measures-of-physiologic-resiliencies-in-human-aging
#15
Evan C Hadley, George A Kuchel, Anne B Newman, Heather G Allore, Jenna M Bartley, Cindy S Bergeman, Michael L Blinov, Cathleen S Colon-Emeric, Firdaus S Dabhar, Laura L Dugan, Chhanda Dutta, Basil A Eldadah, Luigi Ferrucci, James L Kirkland, Stephen B Kritchevsky, Lewis A Lipsitz, Neelesh K Nadkarni, May J Reed, Kenneth E Schmader, Felipe Sierra, Stephanie A Studenski, Ravi Varadhan, Jeremy D Walston, Heather E Whitson, Raymond Yung
No abstract text is available yet for this article.
May 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29765153/cox-2-mediates-pro-tumorigenic-effects-of-pkc%C3%AE%C2%B5-in-prostate-cancer
#16
Rachana Garg, Jorge M Blando, Carlos J Perez, Priti Lal, Michael D Feldman, Emer M Smyth, Emanuela Ricciotti, Tilo Grosser, Fernando Benavides, Marcelo G Kazanietz
The pro-oncogenic kinase PKCε is overexpressed in human prostate cancer and cooperates with loss of the tumor suppressor Pten for the development of prostatic adenocarcinoma. However, the effectors driving PKCε-mediated phenotypes remain poorly defined. Here, using cellular and mouse models, we showed that PKCε overexpression acts synergistically with Pten loss to promote NF-κB activation and induce cyclooxygenase-2 (COX-2) expression, phenotypic traits which are also observed in human prostate tumors. Targeted disruption of PKCε from prostate cancer cells impaired COX-2 induction and PGE2 production...
May 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29764892/intense-exercise-for-survival-among-men-with-metastatic-castrate-resistant-prostate-cancer-interval-gap4-a-multicentre-randomised-controlled-phase-iii-study-protocol
#17
Robert U Newton, Stacey A Kenfield, Nicolas H Hart, June M Chan, Kerry S Courneya, James Catto, Stephen P Finn, Rosemary Greenwood, Daniel C Hughes, Lorelei Mucci, Stephen R Plymate, Stephan F E Praet, Emer M Guinan, Erin L Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A Galvão, Charles J Ryan, Fred Saad
INTRODUCTION: Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC). METHODS AND ANALYSIS: Participants (n=866) must have histologically documented metastatic prostate cancer with evidence of progressive disease on androgen deprivation therapy (defined as mCRPC)...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29757235/clinically-applicable-inhibitors-impacting-genome-stability
#18
REVIEW
Anu Prakash, Juan F Garcia-Moreno, James A L Brown, Emer Bourke
Advances in technology have facilitated the molecular profiling (genomic and transcriptomic) of tumours, and has led to improved stratification of patients and the individualisation of treatment regimes. To fully realize the potential of truly personalised treatment options, we need targeted therapies that precisely disrupt the compensatory pathways identified by profiling which allow tumours to survive or gain resistance to treatments. Here, we discuss recent advances in novel therapies that impact the genome (chromosomes and chromatin), pathways targeted and the stage of the pathways targeted...
May 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29751135/brief-report-on-the-detection-of-the-egfr-t790m-mutation-in-exhaled-breath-condensate-from-lung-cancer-patients
#19
Robert J Smyth, Sinead M Toomey, Alexander Sartori, Emer O Hanrahan, Sinead D Cuffe, Oscar S Breathnach, Ross K Morgan, Bryan T Hennessy
The EGFR-T790M somatic mutation is the most common mechanism of resistance to Tyrosine Kinase Inhibitors (TKI) in non-small cell lung cancer. Patients with advanced disease are not always amenable to repeat biopsy for further molecular analysis. Developing non-invasive methods to detect T790M in cell-free DNA (cfDNA), in the absence of tissue is being actively investigated. Unfortunately the low sensitivity of plasma for T790M detection has limited its clinical use. Exhaled breath condensate (EBC) is an easily collected sample, known to harbour cfDNA, including lung cancer mutations...
May 8, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29733737/leadership-capabilities-of-physiotherapy-leaders-in-ireland-part-1-physiotherapy-managers
#20
Emer McGowan, Naomi Elliott, Emma Stokes
BACKGROUND: Investigation of the leadership capabilities of physiotherapists is needed to allow understanding of current leadership practice and to enable appropriate training programs to be developed. PURPOSE: To explore physiotherapy managers´ perceptions of their leadership capabilities. METHODS: Semi-structured interviews were conducted with a purposive sample of 18 physiotherapy managers from a range of public services and private practices in Ireland...
May 7, 2018: Physiotherapy Theory and Practice
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