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https://www.readbyqxmd.com/read/29678137/supporting-teams-to-optimize-function-and-independence-in-veterans-a-multi-study-program-and-mixed-methods-protocol
#1
Virginia Wang, Kelli Allen, Courtney H Van Houtven, Cynthia Coffman, Nina Sperber, Elizabeth P Mahanna, Cathleen Colón-Emeric, Helen Hoenig, George L Jackson, Teresa M Damush, Erika Price, Susan N Hastings
BACKGROUND: Successful implementation of new clinical programs depends on effectively establishing, reorganizing, or enhancing team structures and processes to coordinate the work of individuals who are interdependent in their tasks, manage relationships, and share responsibility for outcomes. However, a one-size-fits-all approach is rarely effective. In partnership with VA national clinical leaders and local clinical champions, the Optimizing Function and Independence VA Quality Enhancement Research Initiative program (Function QUERI) will evaluate efforts to implement team-based clinical programs for Veterans at risk for functional decline and disability...
April 20, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29676053/increasing-success-in-outpatient-laparoscopic-cholecystectomy-by-an-optimal-clinical-pathway
#2
Tristan Greilsamer, François Orion, Fabrice Denimal, Benoît De Kerviler, Marc-Henri Jean, Jérôme Dimet, Michel Comy, Emeric Abet
BACKGROUND: The objective of this study was to evaluate the impact of more convincing and reassuring remarks from the surgeon in the preoperative consult associated with a dedicated outpatient facility to increase our rate of success in outpatient laparoscopic cholecystectomy. METHODS: A one-centre prospective clinical study was conducted between February 2013 and May 2015. During the first time period (February 2013-March 2014), patients were hospitalized in conventional care unit and given the possibility to choose an outpatient procedure...
April 19, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29659991/consequences-of-asexuality-in-natural-populations-insights-from-stick-insects
#3
Jens Bast, Darren J Parker, Zoé Dumas, Kirsten M Jalvingh, Patrick Tran Van, Kamil S Jaron, Emeric Figuet, Alexander Brandt, Nicolas Galtier, Tanja Schwander
Recombination is a fundamental process with significant impacts on genome evolution. Predicted consequences of the loss of recombination include a reduced effectiveness of selection, changes in the amount of neutral polymorphisms segregating in populations, and an arrest of GC-biased gene conversion. Although these consequences are empirically well documented for non-recombining genome portions, it remains largely unknown if they extend to the whole genome scale in asexual organisms. We identify the consequences of asexuality using de novo transcriptomes of five independently derived, obligately asexual lineages of stick insects and their sexual sister-species...
April 5, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29644001/bag3-promotes-tumour-cell-proliferation-by-regulating-egfr-signal-transduction-pathways-in-triple-negative-breast-cancer
#4
Sarah Shields, Emer Conroy, Tony O'Grady, Alo McGoldrick, Kate Connor, Mark P Ward, Zivile Useckaite, Eugene Dempsey, Rebecca Reilly, Yue Fan, Anthony Chubb, David Gomez Matallanas, Elaine W Kay, Darran O'Connor, Amanda McCann, William M Gallagher, Judith A Coppinger
Triple-negative breast cancer (TNBC), is a heterogeneous disease characterised by absence of expression of the estrogen receptor (ER), progesterone receptor (PR) and lack of amplification of human epidermal growth factor receptor 2 (HER2). TNBC patients can exhibit poor prognosis and high recurrence stages despite early response to chemotherapy treatment. In this study, we identified a pro-survival signalling protein BCL2- associated athanogene 3 (BAG3) to be highly expressed in a subset of TNBC cell lines and tumour tissues...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29625551/foreskin-derived-mesenchymal-stromal-cells-with-aldehyde-dehydrogenase-activity-isolation-and-gene-profiling
#5
Mehdi Najar, Emerence Crompot, Leo A van Grunsven, Laurent Dollé, Laurence Lagneaux
BACKGROUND: Mesenchymal stromal cells (MSCs) become an attractive research topic because of their crucial roles in tissue repair and regenerative medicine. Foreskin is considered as a valuable tissue source containing immunotherapeutic MSCs (FSK-MSCs). RESULTS: In this work, we used aldehyde dehydrogenase activity (ALDH) assay (ALDEFLUOR™) to isolate and therefore characterize subsets of FSK-MSCs. According to their ALDH activity, we were able to distinguish and sort by fluorescence activated cell sorting (FACS) two subsets of FSK-MSCs (referred as ALDH+ and ALDH- )...
April 6, 2018: BMC Cell Biology
https://www.readbyqxmd.com/read/29624063/diastereoselective-synthesis-of-a-dyn-3-arene-with-distinct-binding-behaviors-toward-linear-biogenic-polyamines
#6
Marion Donnier-Maréchal, Jean Septavaux, Emeric Jeamet, Alexandre Héloin, Florent Perret, Elise Dumont, Jean-Christophe Rossi, Fabio Ziarelli, Julien Leclaire, Laurent Vial
The extension of the family of dyn[ n]arenes toward a three-membered macrocycle is reported. Through a templated approach, a single diastereoisomer of a dyn[3]arene that bears six carboxyl groups could be isolated by precipitation in 59-63% yield and excellent purity (≥95%). A combination of experimental and computational experiments in water at physiological pH revealed that the macrocycle could bind parent biogenic polyamines with a unique diversity of surface-binding modes. Whereas no binding event could be accurately measured with 1,3-diaminopropane, spermidine formed a classical stoichiometric complex with the dyn[3]arene in the millimolar concentration range...
April 6, 2018: Organic Letters
https://www.readbyqxmd.com/read/29618937/the-impact-of-alpha-1-antitrypsin-augmentation-therapy-on-neutrophil-driven-respiratory-disease-in-deficient-individuals
#7
REVIEW
Danielle M Dunlea, Laura T Fee, Thomas McEnery, Noel G McElvaney, Emer P Reeves
Alpha-1 antitrypsin (AAT) is the most abundant serine protease inhibitor circulating in the blood. AAT deficiency (AATD) is an autosomal codominant condition affecting an estimated 3.4 million individuals worldwide. The clinical disease associated with AATD can present in a number of ways including COPD, liver disease, panniculitis and antineutrophil cytoplasmic antibody vasculitis. AATD is the only proven genetic risk factor for the development of COPD, and deficient individuals who smoke are disposed to more aggressive disease...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29608130/evaluation-of-a-2-to-1-peer-placement-supervision-model-by-physiotherapy-students-and-their-educators
#8
Lucy M Alpine, Francieli Tanji Caldas, Emer M Barrett
OBJECTIVES: The objective of the study was to investigate student and practice educator evaluations of practice placements using a structured 2 to 1 supervision and implementation model. DESIGN: Cross-sectional pilot study set in clinical sites providing placements for physiotherapy students in Ireland. PARTICIPANTS: Students and practice educators completing a 2.1 peer placement between 2013 and 2015 participated. OUTCOME MEASURE: A self-reported questionnaire which measured indicators linked to quality assured placements was used...
April 2, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29603387/genotype-phenotype-correlations-dystonia-and-disease-progression-in-spinocerebellar-ataxia-type-14
#9
Viorica Chelban, Sarah Wiethoff, Bjørn K Fabian-Jessing, Nourelhoda A Haridy, Alaa Khan, Stephanie Efthymiou, Esther B E Becker, Emer O'Connor, Joshua Hersheson, Katrina Newland, Allan Thomas Hojland, Pernille A Gregersen, Suzanne G Lindquist, Michael B Petersen, Jørgen E Nielsen, Michael Nielsen, Nicholas W Wood, Paola Giunti, Henry Houlden
BACKGROUND: Spinocerebellar ataxia type 14 is a rare form of autosomal dominant cerebellar ataxia caused by mutations in protein kinase Cγ gene. Clinically, it presents with a slowly progressive, mainly pure cerebellar ataxia. METHODS: Using next generation sequencing, we screened 194 families with autosomal dominant cerebellar ataxia and normal polyglutamine repeats. In-depth phenotyping was performed using validated clinical rating scales neuroimaging and electrophysiological investigations...
March 30, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29577234/physical-resilience-not-simply-the-opposite-of-frailty
#10
EDITORIAL
Heather E Whitson, Harvey J Cohen, Kenneth E Schmader, Miriam C Morey, George Kuchel, Cathleen S Colon-Emeric
No abstract text is available yet for this article.
March 25, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29563140/advances-in-neonatal-mri-of-the-brain-from-research-to-practice
#11
Christopher J Kelly, Emer J Hughes, Mary A Rutherford, Serena J Counsell
No abstract text is available yet for this article.
March 21, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29546298/cow-milk-consumption-increases-iodine-status-in-women-of-childbearing-age-in-a-randomized-controlled-trial
#12
S Maria O'Kane, L Kirsty Pourshahidi, Maria S Mulhern, J J Strain, Emer M Mackle, Duygu Koca, Lutz Schomburg, Sarah Hill, Jennifer O'Reilly, Diana Kmiotek, Christian Deitrich, Sarah C Bath, Alison J Yeates
Background: Recent evidence has highlighted the prevalence of mild-to-moderate iodine deficiency in women of childbearing age and pregnant women, with important public health ramifications due to the role of iodine, which is required for thyroid hormone production, in neurodevelopment. Cow milk contributes the greatest amount to iodine intakes in several countries. Objective: The objective of this study was to investigate the effect of increased cow milk consumption on iodine status, thyroid hormone concentrations, and selenium status...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29544346/how-are-people-with-dementia-involved-in-care-planning-and-decision-making-an-irish-social-work-perspective
#13
Sarah Donnelly, Emer Begley, Marita O'Brien
In recent years, there have been national and international policy advances around capacity and decision-making and an apparent burgeoning rights-based approach to the issue, all of which have the potential to impact on the experience for people with dementia in Ireland. There is little evidence however on whether these policies and principles are being translated into practice and whether traditional paternalistic approaches to decision-making are being challenged. To gain insight into current practice, research was undertaken with social workers working with older people in Ireland; reporting on the involvement of people living with dementia in care-planning processes...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29539422/extracellular-neutrophil-proteases-are-efficient-regulators-of-il-1-il-33-and-il-36-cytokine-activity-but-poor-effectors-of-microbial-killing
#14
Danielle M Clancy, Graeme P Sullivan, Hannah B T Moran, Conor M Henry, Emer P Reeves, Noel G McElvaney, Ed C Lavelle, Seamus J Martin
Neutrophil granule proteases are thought to function as anti-microbial effectors, cooperatively hydrolyzing microorganisms within phagosomes, or upon deployment into the extracellular space. However, evidence also suggests that neutrophil proteases play an important role in the coordination and escalation of inflammatory reactions, but how this is achieved has been obscure. IL-1 family cytokines are important initiators of inflammation and are typically released via necrosis but require proteolytic processing for activation...
March 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29524103/the-benefits-of-a-neurogenetics-clinic-in-an-adult-academic-teaching-hospital
#15
Diana A Olszewska, Terri McVeigh, Emer M Fallon, Gregory M Pastores, Tim Lynch
Genetics is the backbone of Neurology, where a number of disorders have a genetic aetiology and are complex, requiring a dedicated Neurogenetics clinic. Genetics in the Republic of Ireland is under-resourced, with the lowest number of consultants per million of population in Europe. In November 2014, we established the monthly adult Neurogenetics clinic in Ireland, staffed by 2 consultants and 2 registrars from each speciality. We see patients with complex rare neurological conditions that may potentially have an underlying genetic basis, in the presence or absence of a family history...
March 9, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29494493/the-effect-of-processing-and-seasonality-on-the-iodine-and-selenium-concentration-of-cow-s-milk-produced-in-northern-ireland-ni-implications-for-population-dietary-intake
#16
S Maria O'Kane, L Kirsty Pourshahidi, Maria S Mulhern, Ruth R Weir, Sarah Hill, Jennifer O'Reilly, Diana Kmiotek, Christian Deitrich, Emer M Mackle, Edel Fitzgerald, Carole Lowis, Mike Johnston, J J Strain, Alison J Yeates
Cow's milk is the most important dietary source of iodine in the UK and Ireland, and also contributes to dietary selenium intakes. The aim of this study was to investigate the effect of season, milk fat class (whole; semi-skimmed; skimmed) and pasteurisation on iodine and selenium concentrations in Northern Ireland (NI) milk, and to estimate the contribution of this milk to consumer iodine and selenium intakes. Milk samples (unpasteurised, whole, semi-skimmed and skimmed) were collected weekly from two large NI creameries between May 2013 and April 2014 and were analysed by inductively coupled plasma-mass spectrometry (ICP-MS)...
March 1, 2018: Nutrients
https://www.readbyqxmd.com/read/29479247/update-for-canadian-nrp-providers-a-case-based-review
#17
Emer Finan, Douglas M Campbell, Khalid Aziz, Patrick J McNamara
The International Liaison Committee on Resuscitation (ILCOR) Neonatal Task Force reviews available resuscitation science every 5 years and develops guidelines which are integrated into educational programs such as the Neonatal Resuscitation Program (NRP). The most recent ILCOR Neonatal Task Force consensus guidelines were published in October 2015. The Canadian Paediatric Society's NRP Steering Committee has reviewed ILCOR guidelines alongside the 7th edition (2016) NRP materials. Using a case-based approach, this practice point highlights the main changes relating to the delivery of NRP, within the Canadian context...
September 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29476506/substrate-capture-assay-using-inactive-oligopeptidases-to-identify-novel-peptides
#18
Vanessa Rioli, Emer S Ferro
Researchers are always searching for novel biologically active molecules including peptides. With the improvement of equipment for electrospray mass spectrometry, it is now possible to identify hundreds of novel peptides in a single run. However, after identifying the peptide sequences it is expensive to synthesize all the peptides to perform biological activity assays. Here, we describe a substrate capture assay that uses inactive oligopeptidases to identify putative biologically active peptides in complexes peptide mixtures...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29474996/considerations-for-exercise-prescription-in-patients-with-bone-metastases-a-comprehensive-narrative-review
#19
REVIEW
Gráinne Sheill, Emer M Guinan, Nicola Peat, Juliette Hussey
Metastatic disease is a frequent complication of advanced cancer, with bone representing one of the most common sites of metastatic occurrence. Patients with bone metastases receive long-term systemic treatments that have a significant attritional impact on muscle strength, fatigue, and physical functioning. Physical rehabilitation involving exercise and physical activity prescription has a considerable role in counteracting these changes; however, exercise is often perceived as a contraindication in the presence of bone metastases due to concerns about aggravating skeletal related events...
February 21, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29471012/pediatric-fatty-liver-disease-pefld-all-is-not-nafld-pathophysiological-insights-and-approach-to-management
#20
REVIEW
Robert Hegarty, Maesha Deheragoda, Emer Fitzpatrick, Anil Dhawan
The recognition of a pattern of steatotic liver injury where histology mimicked alcoholic liver disease but alcohol consumption was denied, led to the identification of non-alcoholic fatty liver disease (NAFLD). Non-alcoholic fatty liver disease has since become the most common chronic liver disease in adults owing to the global epidemic of obesity. However, in pediatrics, the term NAFLD seems incongruous: alcohol consumption is largely not a factor and inherited metabolic disorders (IMD) can mimic or co-exist with a diagnosis of NAFLD...
February 19, 2018: Journal of Hepatology
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