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https://www.readbyqxmd.com/read/28920571/recurrent-seasonal-outbreak-of-an-emerging-serotype-of-shiga-toxin-producing-escherichia-coli-stec-o55-h7-stx2a-in-the-south-west-of-england-july-2014-to-september-2015
#1
Noëleen McFarland, Nick Bundle, Claire Jenkins, Gauri Godbole, Amy Mikhail, Tim Dallman, Catherine O'Connor, Noel McCarthy, Emer O'Connell, Juli Treacy, Girija Dabke, James Mapstone, Yvette Landy, Janet Moore, Rachel Partridge, Frieda Jorgensen, Caroline Willis, Piers Mook, Chas Rawlings, Richard Acornley, Charlotte Featherstone, Sharleen Gayle, Joanne Edge, Eleanor McNamara, Jeremy Hawker, Sooria Balasegaram
The first documented British outbreak of Shiga toxin-producing Escherichia coli (STEC) O55:H7 began in the county of Dorset, England, in July 2014. Since then, there have been a total of 31 cases of which 13 presented with haemolytic uraemic syndrome (HUS). The outbreak strain had Shiga toxin (Stx) subtype 2a associated with an elevated risk of HUS. This strain had not previously been isolated from humans or animals in England. The only epidemiological link was living in or having close links to two areas in Dorset...
September 7, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28920098/the-il-1ri-co-receptor-tilrr-frem1%C3%A2-isoform-2-controls-aberrant-inflammatory-responses-and-development-of-vascular-disease
#2
Sarah A Smith, Andriy O Samokhin, Mabruka Alfadi, Emer C Murphy, David Rhodes, W Mike L Holcombe, Endre Kiss-Toth, Robert F Storey, Siu-Pok Yee, Sheila E Francis, Eva E Qwarnstrom
Expression of the interleukin-1 receptor type I (IL-1RI) co-receptor Toll-like and interleukin-1 receptor regulator (TILRR) is significantly increased in blood monocytes following myocardial infarction and in the atherosclerotic plaque, whereas levels in healthy tissue are low. TILRR association with IL-1RI at these sites causes aberrant activation of inflammatory genes, which underlie progression of cardiovascular disease. The authors show that genetic deletion of TILRR or antibody blocking of TILRR function reduces development of atherosclerotic plaques...
August 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28919886/dna-adenine-methyltransferase-dam-overexpression-impairs-photorhabdus-luminescens-motility-and-virulence
#3
Amaury Payelleville, Anne Lanois, Marie Gislard, Emeric Dubois, David Roche, Stéphane Cruveiller, Alain Givaudan, Julien Brillard
Dam, the most described bacterial DNA-methyltransferase, is widespread in gamma-proteobacteria. Dam DNA methylation can play a role in various genes expression and is involved in pathogenicity of several bacterial species. The purpose of this study was to determine the role played by the dam ortholog identified in the entomopathogenic bacterium Photorhabdus luminescens. Complementation assays of an Escherichia coli dam mutant showed the restoration of the DNA methylation state of the parental strain. Overexpression of dam in P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28917977/the-role-of-the-endocannabinoid-system-in-the-antihyperalgesic-effect-of-cedrus-atlantica-essential-oil-inhalation-in-a-mouse-model-of-postoperative-pain
#4
Aline Armiliato Emer, Nathalia Nahas Donatello, Ana Paula Batisti, Luiz Augusto de Oliveira Belmonte, Adair R S Santos, Daniel F Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Cedar is part of the phylum of conifers, and it´s essential oil has been used for therapeutic purposes since ancient times. In our previous study, we have demonstrated that the inhalation of the Cedrus atlantica essential oil (CaEO) induces an antihyperalgesic effect in a model of postoperative pain. But the mechanism that underlies this effect is not yet fully known. AIM OF THE STUDY: This study investigates the involvement of the endocannabinoid system in the antihyperalgesic effect produced by the inhalation of CaEO in a post operative pain model...
September 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28892041/guide-bound-structures-of-an-rna-targeting-a-cleaving-crispr-cas13a-enzyme
#5
Gavin J Knott, Alexandra East-Seletsky, Joshua C Cofsky, James M Holton, Emeric Charles, Mitchell R O'Connell, Jennifer A Doudna
CRISPR adaptive immune systems protect bacteria from infections by deploying CRISPR RNA (crRNA)-guided enzymes to recognize and cut foreign nucleic acids. Type VI-A CRISPR-Cas systems include the Cas13a enzyme, an RNA-activated RNase capable of crRNA processing and single-stranded RNA degradation upon target-transcript binding. Here we present the 2.0-Å resolution crystal structure of a crRNA-bound Lachnospiraceae bacterium Cas13a (LbaCas13a), representing a recently discovered Cas13a enzyme subtype. This structure and accompanying biochemical experiments define the Cas13a catalytic residues that are directly responsible for crRNA maturation...
September 11, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28881426/autoantibody-production-in-rheumatoid-arthritis-associated-with-alpha-1-antitrypsin-deficiency-is-complex-and-likely-driven-by-inflammation-and-neutrophil-dysfunction
#6
Cormac McCarthy, Carl Orr, Ursula Fearon, Douglas J Veale, Emer P Reeves, Noel G McElvaney
We thank Drs Hutchinson and Eggleton for their interest in our report and for raising some interesting points. While we believe there is some merit in the issues they raise, we do not believe these invalidate the data we have presented or the conclusions we made in our initial report. This article is protected by copyright. All rights reserved.
September 7, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28878916/what-is-the-cause-of-this-synchronous-palpable-abdominal-mass-in-a-woman-recently-diagnosed-with-lung-cancer-as-demonstrated-in-figure%C3%A2-1
#7
Gerard Feeney, Emer O'Connell, Mike Flood, Cyril Rooney, Fadel Bennani, Kevin Barry
Colonic metastases from lung cancer are rare [1, 2]. Presentation of an abdominal mass in the setting of a new lung cancer diagnosis should prompt complete evaluation including endoscopic and CT imaging. This case also highlights the need for immunohistochemical analysis of unusual tumor deposits facilitating appropriate treatment.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28877576/unusual-location-of-hydatid-cysts-report-of-two-cases-in-the-heart-and-hip-joint-of-romanian-patients
#8
Simona Gurzu, Marius Alexandru Beleaua, Emeric Egyed-Zsigmond, Ioan Jung
Hydatid cyst is usually located in the liver and lungs, rare cases showing localization in other organs or tissues. In the unusual location, echinococcosis is an excluding diagnosis that is established only after microscopic evaluation. Our first case occurred in a 67-year-old female previously diagnosed with pulmonary tuberculosis and hospitalized with persistent pain in the hip joint. The clinical diagnosis was tuberculosis of the joint, but the presence of the specific acellular membrane indicated a hydatid cyst of the synovial membrane, without bone involvement...
August 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28852365/iowa-orthopedic-journal-editors-emeriti
#9
(no author information available yet)
No abstract text is available yet for this article.
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28841142/validation-of-a-high-sampling-rate-inertial-measurement-unit-for-acceleration-during-running
#10
Thomas Provot, Xavier Chiementin, Emeric Oudin, Fabrice Bolaers, Sébastien Murer
The musculo-skeletal response of athletes to various activities during training exercises has become a critical issue in order to optimize their performance and minimize injuries. However, dynamic and kinematic measures of an athlete's activity are generally limited by constraints in data collection and technology. Thus, the choice of reliable and accurate sensors is crucial for gathering data in indoor and outdoor conditions. The aim of this study is to validate the use of the accelerometer of a high sampling rate ( 1344 Hz ) Inertial Measurement Unit (IMU) in the frame of running activities...
August 25, 2017: Sensors
https://www.readbyqxmd.com/read/28835336/neutrophil-membrane-cholesterol-content-is-a-key-factor-in-cystic-fibrosis-lung-disease
#11
Michelle M White, Patrick Geraghty, Elaine Hayes, Stephen Cox, William Leitch, Bader Alfawaz, Gillian M Lavelle, Oliver J McElvaney, Ryan Flannery, Joanne Keenan, Paula Meleady, Michael Henry, Martin Clynes, Cedric Gunaratnam, Noel G McElvaney, Emer P Reeves
BACKGROUND: Identification of mechanisms promoting neutrophil trafficking to the lungs of patients with cystic fibrosis (CF) is a challenge for next generation therapeutics. Cholesterol, a structural component of neutrophil plasma membranes influences cell adhesion, a key step in transmigration. The effect of chronic inflammation on neutrophil membrane cholesterol content in patients with CF (PWCF) remains unclear. To address this we examined neutrophils of PWCF to evaluate the cause and consequence of altered membrane cholesterol and identified the effects of lung transplantation and ion channel potentiator therapy on the cellular mechanisms responsible for perturbed membrane cholesterol and increased cell adhesion...
August 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28815552/connect-home-transitional-care-of-skilled-nursing-facility-patients-and-their-caregivers
#12
Mark Toles, Cathleen Colón-Emeric, Mary D Naylor, Josephine Asafu-Adjei, Laura C Hanson
BACKGROUND: Older adults that transfer from skilled nursing facilities (SNF) to home have significant risk for poor outcomes. Transitional care of SNF patients (i.e., time-limited services to ensure coordination and continuity of care) is poorly understood. OBJECTIVE: To determine the feasibility and relevance of the Connect-Home transitional care intervention, and to compare preparedness for discharge between comparison and intervention dyads. DESIGN: A non-randomized, historically controlled design-enrolling dyads of SNF patients and their family caregivers...
August 16, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28796735/is-the-failure-of-laparoscopic-peritoneal-lavage-predictable-in-hinchey-iii-diverticulitis-management
#13
Tristan Greilsamer, Emeric Abet, Guillaume Meurette, Michel Comy, Antoine Hamy, Paul-Antoine Lehur, Aurélien Venara, Emilie Duchalais
BACKGROUND: Laparoscopic peritoneal lavage is an alternative to sigmoid resection in Hinchey III diverticulitis (generalized purulent peritonitis). The main limitation of laparoscopic peritoneal lavage is the higher rate of reoperation for persistent sepsis in comparison with sigmoid resection. OBJECTIVE: The purpose of the current study was to identify risk factors for laparoscopic peritoneal lavage failure in patients who have Hinchey III diverticulitis. DESIGN: This was a retrospective multicenter study...
September 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28796017/sarcopenia-prevalence-and-impact-on-operative-and-oncologic-outcomes-in-the-multimodal-management-of-locally-advanced-esophageal-cancer
#14
Jessie A Elliott, Suzanne L Doyle, Conor F Murphy, Sinead King, Emer M Guinan, Peter Beddy, Narayanasamy Ravi, John V Reynolds
OBJECTIVE: The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes. SUMMARY OF BACKGROUND DATA: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied. METHODS: Two hundred fifty-two consecutive patients were studied...
August 8, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28791546/quantitative-analysis-of-photoreceptor-layer-reflectivity-on-en-face-optical-coherence-tomography-as-an-estimator-of-cone-density
#15
Maher Saleh, Mathieu Flores, Anne Sophie Gauthier, Emeric Elphege, Bernard Delbosc
BACKGROUND: To investigate whether outer retinal reflectivity on en-face Optical coherence tomography (OCT) can be considered as an estimator of cone density measured in the same area. METHODS: Forty-one points of comparisons were studied in 9 eyes (n = 6 patients) presenting maculopathies with various degrees of impairment of the photoreceptor layer. The inner segment ellipsoid zone (EZ), interdigitation zone (IZ), and retinal pigment epithelium (RPE) reflectivity were measured on coronal reconstruction of the photoreceptor layer using homemade dedicated software (Matlab, MathWorks Inc...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28789652/exploring-the-relationship-between-general-practice-characteristics-and-attendance-at-walk-in-centres-minor-injuries-units-and-emergency-departments-in-england-2009-10-2012-2013-a-longitudinal-study
#16
Peter Tammes, Richard W Morris, Emer Brangan, Kath Checkland, Helen England, Alyson Huntley, Daniel Lasserson, Fiona MacKichan, Chris Salisbury, Lesley Wye, Sarah Purdy
BACKGROUND: The UK National Health Service Emergency Departments (ED) have recently faced increasing attendance rates. This study investigated associations of general practice and practice population characteristics with emergency care service attendance rates. METHODS: A longitudinal design with practice-level measures of access and continuity of care, patient population demographics and use of emergency care for the financial years 2009/10 to 2012/13. The main outcome measures were self-referred discharged ED attendance rate, and combined self-referred discharged ED, self-referred Walk-in Centre (WiC) and self-referred Minor Injuries Unit (MIU) attendance rate per 1000 patients...
August 8, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28760511/interarm-blood-pressure-difference-in-a-post-stroke%C3%A2-population
#17
Eva Gaynor, Linda Brewer, Lisa Mellon, Patricia Hall, Frances Horgan, Emer Shelley, Eamonn Dolan, Anne Hickey, Kathleen Bennett, David J Williams
An increased interarm systolic blood pressure (SBP) difference of ≥10 mm Hg is associated with increased cardiovascular risk and a difference of ≥15 mm Hg with increased cerebrovascular risk. The stroke population presents a high-risk group for future cardiovascular and cerebrovascular events and therefore estimation of interarm SBP difference as a predictive tool may assist with further secondary stroke prevention. The aim of the study was to determine the prevalence of interarm SBP and diastolic blood pressure difference in a post-stroke population...
July 4, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28745921/recovery-based-training-in-mental-health-effects-on-staff-knowledge-and-attitudes-to-recovery
#18
Francis Patrick Walsh, Pauline Meskell, Emer Burke, Maura Dowling
This longitudinal study describes the effects of recovery-based training on staff knowledge and attitudes to recovery. Mental health staff (n = 101) completed the study questionnaire (the Recovery Knowledge Inventory (RKI-20) and Recovery Attitudes' Questionnaire (RAQ-16)) before training and after six months. On the RKI, significant changes between pre- and post-training scores (p < 0.01) were found. On the RAQ, the scores showed significant changes in Factors 1 (p < 0.001) and 2 (p < 0.009). The results indicate a significant difference in confidence using a recovery model of care following training suggesting that recovery-based training positively affects staff knowledge and attitudes to recovery overall...
July 26, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28737568/systematic-review-nutrition-and-physical-activity-in-the-management-of-paediatric-nonalcoholic-fatty-liver-disease
#19
Philippa S Gibson, Sarah Lang, Anil Dhawan, Emer Fitzpatrick, Michelle L Blumfield, Helen Truby, Kathryn H Hart, J Bernadette Moore
OBJECTIVES: The aim of the study was to evaluate efficacy of nutrition and physical activity interventions in the clinical management of paediatric nonalcoholic fatty liver disease. The prevalence of paediatric nonalcoholic fatty liver disease continues to rise alongside childhood obesity. Weight loss through lifestyle modification is currently first-line treatment, although supplementation of specific dietary components may be beneficial. METHODS: Medline, CINAHL, EMBASE, Scopus, and Cochrane Libraries were systematically searched to identify randomized controlled trials assessing nutritional and physical activity interventions...
August 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28735981/autoimmune-liver-disease-in-children-with-sickle-cell-disease
#20
Suttiruk Jitraruch, Emer Fitzpatrick, Maesha Deheragoda, Annamaria Deganello, Giorgina Mieli-Vergani, Susan Height, David Rees, Nedim Hadzic, Marianne Samyn
OBJECTIVE: To assess the incidence, clinical features, and outcome of autoimmune liver disease (AILD) in patients with sickle cell disease (SCD). STUDY DESIGN: Single center retrospective review of patients with SCD with AILD referred between 1999 and 2015. RESULTS: Thirteen of 77 (17%) patients with SCD with hepatic dysfunction were diagnosed with AILD (median age 11, range, 3.4-16 years) with a female preponderance (77%). Acute hepatitis and insidious onset were the commonest presentations...
July 20, 2017: Journal of Pediatrics
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