keyword
https://read.qxmd.com/read/37817020/green-synthesis-of-nano-based-drug-delivery-systems-developed-for-hepatocellular-carcinoma-treatment-a-review
#21
REVIEW
Doaa S R Khafaga, Ahmed M El-Khawaga, Rehab Abd Elfattah Mohammed, Heba K Abdelhakim
This review presents an overview of one of the effective strategies for improving the anticancer impact of many drugs including sorafenib using a drug delivery system by employing nanoparticles that is produced through a biological system. The biological process has a lot of benefits, including being inexpensive and safe for the environment. Sorafenib is one of a multi-kinase inhibitor that inhibits molecularly targeted kinases. Because of its poor pharmacokinetic characteristics, such as fast elimination and limited water solubility, the bioavailability of Sorafenib is extremely low...
October 10, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37779590/protective-effects-of-cardamom-aqueous-extract-against-tamoxifen-induced-pancreatic-injury-in-female-rats
#22
JOURNAL ARTICLE
Hala Attia, Afraa Alzoubi, Nour Al-Anazi, Aliah Alshanwani, Naglaa El-Orabi, Alaa Alanteet, Raeesa Mohamad, Rehab Ali
UNLABELLED: Tamoxifen (TAM) is a commonly used drug for breast cancer treatment. Although effective, TAM has deleterious effects on many organs. The toxic effects of TAM on the pancreas and the underlying mechanisms however, have not fully investigated. In the present study, we investigated the effects of TAM on the pancreatic tissue in female rats. We also examined whether cardamom aqueous extract (CAE) protects against TAM-induced pancreatic injury. TAM-intoxicated rats were injected with 45 mg/kg of TAM for 10 days, whereas rats in the CAE-treated group were administered 10 mL/kg of CAE for 20 days, starting 10 days prior to TAM administration...
October 2023: Toxicological Research
https://read.qxmd.com/read/37776415/association-of-hotair-gene-rs920778-c%C3%A2-%C3%A2-t-and-rs4759314-a%C3%A2-%C3%A2-g-polymorphism-with-breast-cancer-in-egyptian-women
#23
JOURNAL ARTICLE
Nahla Anber, Mohammad M Tarabay, Rehab Elmougy, Marwa Ahmed Abdel-Dayem, Ehab Yones Elbendary
BACKGROUND: Hox transcript antisense RNA (HOTAIR) is considered an oncogene associated with the initiation and progression of many malignancies. Previous studies have examined the connection between HOTAIR SNPs rs4759314 and rs920778 for breast cancer (BC), getting variable results in multiple ethnicities. Therefore, this study was designed to evaluate the connection between these two SNPs and disease vulnerability, clinic-laboratory, and hormonal parameters, featuring status associations with the BC risk in an Egyptian woman sample...
September 30, 2023: Molecular Biology Reports
https://read.qxmd.com/read/37760826/a-new-cu-fe-layer-double-hydroxide-nanocomposite-exerts-anticancer-effects-against-pc-3-cells-by-inducing-cell-cycle-arrest-and-apoptosis
#24
JOURNAL ARTICLE
Mohamed Y Zaky, Rehab Mahmoud, Ahmed A Farghali, Hany Abd El-Raheem, Ahmed Hassaballa, Mohamed Mohany, Dalal Hussien M Alkhalifah, Wael N Hozzein, Abdelrahman Mohamed
Prostate cancer treatment poses significant challenges due to its varying aggressiveness, potential for metastasis, and the complexity of treatment options. Balancing the effectiveness of therapies, minimizing side effects, and personalizing treatment strategies are ongoing challenges in managing this disease. Significant advances in the use of nanotechnology for the treatment of prostate cancer with high specificity, sensitivity, and efficacy have recently been made. This study aimed to synthesize and characterize a novel Cu/Fe layer double hydroxide (LDH) nanocomposite for use as an anticancer agent to treat prostate cancer...
August 25, 2023: Biomedicines
https://read.qxmd.com/read/37749675/intermittent-fasting-protects-against-age-induced-rat-benign-prostatic-hyperplasia-via-preservation-of-prostatic-histomorphology-modification-of-oxidative-stress-and-beclin-1-p62-pathway
#25
JOURNAL ARTICLE
Nashwa Fathy Gamal El-Tahawy, Rehab Ahmed Rifaai
Intermittent fasting (IF) has several beneficial effects on most age-related degenerative changes in the body. Here we aimed to investigate the impact of IF on the biochemical and morphological abnormalities associated with normal aging in rat prostate. Thirty male albino rats were used and divided into three equal groups: adult group, rats aged 3 months; aged group, rats aged 15 months; and IF-aged group, rats aged 15 months maintained on intermittent fasting. After 3 months, prostates were excised and processed for biochemical, histological, and immunohistochemical study...
June 9, 2023: Microscopy and Microanalysis
https://read.qxmd.com/read/37748386/exploring-novel-anticancer-pyrazole-benzenesulfonamides-featuring-tail-approach-strategy-as-carbonic-anhydrase-inhibitors
#26
JOURNAL ARTICLE
Rehab F Ahmed, Walaa R Mahmoud, Nagwa M Abdelgawad, Marwa A Fouad, Mona F Said
This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide compounds were synthesized with variable groups like sulphamoyl group as in compounds 4a-e, its bioisosteric carboxylic acid as in compounds 5a-e and 8e, ethyl carboxylate ester as in compounds 6a-e and 9a-e, which were designed as potential prodrugs, isothiazole ring as in compound 7, hydrazide derivative 10e, hydroxamic acid derivatives 11a-e and semicarbazide derivatives 12a-c,e...
September 19, 2023: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/37658354/herbal-melanin-modulates-pge2-and-il-6-gastroprotective-markers-through-cox-2-and-tlr4-signaling-in-the-gastric-cancer-cell-line-ags
#27
JOURNAL ARTICLE
Adila El-Obeid, Yahya Maashi, Rehab AlRoshody, Ghada Alatar, Modhi Aljudayi, Hamad Al-Eidi, Nouf AlGaith, Altaf Husain Khan, Adil Hassib, Sabine Matou-Nasri
We reported a gastric anti-ulcerogenic effect of the Nigella sativa (L.)-derived herbal melanin (HM) using rat models. However, the molecular mechanisms underlying this HM gastroprotective effect remain unknown. Cyclooxygenase-2 (COX-2)-catalyzed prostaglandin E2 (PGE2) and toll-like receptor 4 (TLR4)-mediated interleukin-6 (IL-6) production and secretion play major roles in gastric mucosal protection. In the current study, the human gastric carcinoma epithelial cell line AGS was used as a model to investigate the effect of HM on TLR4, COX-2, glycoprotein mucin 4 protein and gene expression using immuno-cyto-fluorescence staining, Western blot technology, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
September 1, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37625210/novel-4-2-arylidenehydrazineyl-thienopyrimidine-derivatives-as-anticancer-egfr-inhibitors-design-synthesis-biological-evaluation-kinome-selectivity-and-in-silico-insights
#28
JOURNAL ARTICLE
Heba A Elsebaie, Eman A El-Bastawissy, Kamel M Elberembally, Eman F Khaleel, Rehab Mustafa Badi, Moataz A Shaldam, Wagdy M Eldehna, Haytham O Tawfik, Tarek F El-Moselhy
The current study discovered fifteen new thieno[2,3-d]pyrimidine derivatives with potential anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that compounds 5f-i and 7a significantly inhibited the proliferation of MDA-MB-468 cells at mean GI% and GI50 levels. Compared to staurosporine, these compounds (5f-i and 7a) demonstrated better safety towards typical WI-38 cells. Compounds 5g and 7a demonstrated the highest inhibition (two-digit nanomolar) when compared to erlotinib when their potency was tested on EGFR kinase...
August 22, 2023: Bioorganic Chemistry
https://read.qxmd.com/read/37485329/effectiveness-of-a-personalized-digital-exercise-and-nutrition-based-rehab-program-for-patients-with-gastric-cancer-after-surgery-study-protocol-for-a-randomized-controlled-trial
#29
JOURNAL ARTICLE
Inah Kim, Ji Young Lim, Jong Kwang Kim, Jun Ho Lee, Tae Sung Sohn, Sungsoo Park, Seok Ho Kang, Ji Youl Lee, Ji Hye Hwang
BACKGROUND: Patients with gastric cancer often encounter impaired quality of life and reduced tolerability to adjuvant treatments after surgery. Weight preservation is crucial for the overall prognosis of these patients, and exercise and supplemental nutrition play the main role. This study is the first randomized clinical trial to apply personalized, treatment stage-adjusted digital intervention with wearable devices in gastric cancer rehabilitation intervention for 12 months, commencing immediately after surgery...
2023: Digital Health
https://read.qxmd.com/read/37385311/potential-of-curcumin-and-niacin-loaded-targeted-chitosan-coated-liposomes-to-activate-autophagy-in-hepatocellular-carcinoma-cells-an-in-vitro-evaluation-in-hepg2-cell-line
#30
JOURNAL ARTICLE
Nemany A N Hanafy, Rehab Fouad Sheashaa, Eman A Moussa, Magdy E Mahfouz
The objective of this study is to activate autophagy in hepatocellular carcinoma for the enhancement of its cellular degradation. Liposomes incorporated chitosan in the core used to improve the stability of lecithin and increase the niacin loading efficiency. Additionally, curcumin as a hydrophobic molecule entrapped into liposomal layers and used as a face layer to minimize the release of niacin in physiological pH 7.2. Folic acid-conjugated chitosan was used to facilitate the delivery of liposomes into a specific location of cancer cells...
June 27, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37290189/lactoferrin-antimicrobial-impacts-genomic-guardian-therapeutic-uses-and-clinical-significance-for-humans-and-animals
#31
REVIEW
Mohamed E Abd El-Hack, Sameh A Abdelnour, Mahmoud Kamal, Asmaa F Khafaga, Afnan M Shakoori, Rehab M Bagadood, Hind M Naffadi, Areej Y Alyahyawi, Hanan Khojah, Saleh Alghamdi, Mariusz Jaremko, Sylwester Świątkiewicz
Lactoferrin (LF) is a protein found in several bodily fluids, such as milk. This protein has a diverse range of functions and is evolutionarily conserved. Lactoferrin is a multifunction protein with distinct biological abilities affecting mammals' immune structures. Reports indicated that the daily uptake of LF from dairy products is unsatisfactory in detecting further health-promoting abilities. Research has shown that it protects against infection, mitigates cellular senescence, and improves nutritional quality...
June 6, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/37266340/bladder-preservation-by-neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiation-for-muscle-invasive-bladder-cancer
#32
JOURNAL ARTICLE
Dalia Hamouda Elsayed, Ola M Elfarargy, Mohamed Salah Elderey, Doaa Mandour, Nora Atef, Rehab Hemeda, Mostafa Kamel, Ahmed Azony, Heba F Taha
INTRODUCTION: In Egypt, bladder cancer (BC) represents about 8.7% of cancers in both sexes. In Egyptian men, it accounts for over 30% of all cancers, which makes it the second most frequent cancer. The standard curative treatment for patients with muscle-invasive bladder cancer (MIBC) has been radical cystectomy (RC) with urinary diversion and pelvic lymphadenectomy. Concomitant chemoradiation therapy (CCRT) in MIBC appears to produce results that are comparable to those of RC. MATERIAL AND METHODS: Between January 2018 and March 2021, 34 BC- diagnosed patients, who refused RC, were enrolled...
2023: Contemporary Oncology Współczesna Onkologia
https://read.qxmd.com/read/37264662/potential-of-nanotechnology-to-replace-cancer-stem-cells
#33
JOURNAL ARTICLE
Muhammad Ammar Amanat, Anum Farrukh, Muhammad Umer Bin Muhammad Ishaq, Binyameen Bin Shafqat, Saqib Hussain Haidri, Rehab Amin, Rafia Sameen, Tahira Kamal, Muhammad Naeem Riaz, Waleed Quresh, Rabia Ikram, Ghulam Muhammad Ali, Sania Begum, Sajid Ali Khan Bangash, Imdad Kaleem, Shahid Bashir, Sahir Hameed Khattak
Stem cells, which were initially identified in the 1900s, are distinct cells with the potential to replenish themselves as well as differentiate into specialised cells with certain forms and functions. Cancer stem cells play a significant role in the growth and recurrence of the tumours and, similar to normal stem cells, are capable of proliferating and differentiating. Traditional cancer treatments are ineffective against cancer stem cells, which leads to tumour regrowth. Cancer stem cells are thought to emerge as a result of epithelial-to-mesenchymal transition pathways...
June 1, 2023: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/37174970/optimal-skin-cancer-detection-model-using-transfer-learning-and-dynamic-opposite-hunger-games-search
#34
JOURNAL ARTICLE
Abdelghani Dahou, Ahmad O Aseeri, Alhassan Mabrouk, Rehab Ali Ibrahim, Mohammed Azmi Al-Betar, Mohamed Abd Elaziz
Recently, pre-trained deep learning (DL) models have been employed to tackle and enhance the performance on many tasks such as skin cancer detection instead of training models from scratch. However, the existing systems are unable to attain substantial levels of accuracy. Therefore, we propose, in this paper, a robust skin cancer detection framework for to improve the accuracy by extracting and learning relevant image representations using a MobileNetV3 architecture. Thereafter, the extracted features are used as input to a modified Hunger Games Search (HGS) based on Particle Swarm Optimization (PSO) and Dynamic-Opposite Learning (DOLHGS)...
April 28, 2023: Diagnostics
https://read.qxmd.com/read/37148827/low-baseline-vitamin-d-levels-increase-the-risk-of-bone-metastases-among-females-with-breast-cancer-hospital-based-cohort-study
#35
JOURNAL ARTICLE
Rehab F Mohamed, Dina B S Barakat, Samir Eid, Dalia T Kamal, Maha S Elnaggar
BACKGROUND: Serum vitamin D (Vit-D) has been linked to the development of breast cancer (BC); however, their effect on pathological features and outcomes is undetermined. The purpose of this study was to examine the prognostic significance of baseline Vit-D levels and their effect on clinical outcomes. METHODS: We evaluated baseline serum Vit-D levels and baseline clinic-pathological features of female patients with non-metastatic BC between October 2018 and December 2019...
May 4, 2023: Cancer Epidemiology
https://read.qxmd.com/read/37043965/role-of-long-non-coding-rnas-in-pancreatic-cancer-pathogenesis-and-treatment-resistance-a-review
#36
REVIEW
Tohada M Al-Noshokaty, Abdallah Mansour, Rehab Abdelhamid, Nourhan Abdellatif, Ayat Alaaeldien, Tasnim Reda, Nourhan M Abdelmaksoud, Ahmed S Doghish, Ahmed I Abulsoud, Shereen Saeid Elshaer
Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The lack of reliable means of early cancer detection contributes to this disease's dismal prognosis. Long non-coding RNAs (LncRNAs) are protein-free RNAs produced by genome transcription; they play critical roles in gene expression regulation, epigenetic modification, cell proliferation, differentiation, and reproduction. Recent research has shown that lncRNAs play important regulatory roles in PC behaviors, in addition to their recently found functions...
April 6, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/36999878/prehab-to-rehab-living-with-and-beyond-cancer
#37
EDITORIAL
Clare Shaw, Rachael Barlow, Sorrel Burden
No abstract text is available yet for this article.
April 2023: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/36995465/therapeutic-impact-of-purified-trichoderma-viride-l-asparaginase%C3%A2-in-murine-model-of-liver-cancer-and-in-vitro-hep-g2-cell-line
#38
JOURNAL ARTICLE
Dina H El-Ghonemy, Sanaa A Ali, Rehab M Abdel-Megeed, Ali M Elshafei
BACKGROUND: Hepatocellular carcinoma (HCC) is among the common cancers, but difficult to diagnose and treat. L-asparaginase has been introduced in the treatment protocol of pediatric acute lymphoblastic leukemia (ALL) since the 1960s with a good outcome and increased survival rates to nearly 90%. Moreover, it has been found to have therapeutic potential in solid tumors. Production of glutaminase-free-L-asparaginase is of interest to avoid glutaminase-related toxicity and hypersensitivity...
March 30, 2023: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/36984547/chemical-composition-antibacterial-activity-and-in-vitro-anticancer-evaluation-of-ochradenus-baccatus-methanolic-extract
#39
JOURNAL ARTICLE
Weam M A Khojali, Weiam Hussein, Mohammed Khaled Bin Break, Ahmed Alafnan, Bader Huwaimel, Nasrin E Khalifa, Wafa F S Badulla, Raghad Abdulkarem Alshammari, Lama Khalid Alshammari, Rehab Aladham Raji Alshammari, Sara Mohsen Albarak, Enas Hmdan Alrkad, Tooba Mahboob, Hisham Alshammari
Background and Objectives: Ochradenus baccatus belongs to the family Resedaceae. It is widely spread in Saudi Arabia and other countries in Southwest Asia. O. baccatus is extensively used in traditional medicine as an anti-inflammatory and antibacterial agent, in addition to being a vital source of food for certain desert animal species. The aim of the present study was to investigate the chemical composition and antibacterial/anticancer activities of O. baccatus methanolic extracts collected from Hail, Saudi Arabia...
March 10, 2023: Medicina
https://read.qxmd.com/read/36980656/young-adult-german-breast-cancer-patients-participating-in-a-three-week-inpatient-mother-child-rehab-program-have-high-needs-for-supportive-care
#40
JOURNAL ARTICLE
Friederike Hammersen, Dorothea Fischer, Telja Pursche, Angelika M Strobel, Alexander Katalinic, Louisa Labohm, Annika Waldmann
A known cut-off problem hampers the interpretation of quality of life (QOL) scores. The purpose of this study was to apply a novel approach for the EORTC QLQ-C30 instrument to identify the proportion of breast cancer (BC) patients in need of supportive care. Changes in QOL during the COVID-19 pandemic were evaluated, as well as changes over time (after treatment termination and up to 4 years later). Data were obtained from a cohort study on young adult BC patients with minor children participating in a mother-child rehab program...
March 15, 2023: Cancers
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