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https://www.readbyqxmd.com/read/29764435/use-of-hospital-palliative-care-according-to-the-place-of-death-and-disease-one-year-before-death-in-2013-a-french-national-observational-study
#1
Claire Poulalhon, Laureen Rotelli-Bihet, Sébastien Moine, Anne Fagot-Campagna, Régis Aubry, Philippe Tuppin
BACKGROUND: Only limited data are available concerning the diseases managed before death and hospital palliative care (HPC) use according to place of death in France. We therefore conducted an observational study based on administrative health data in a large population to identify the diseases treated one year before death in 2013, the place of stay with or without hospital palliative care, and the place of death. METHODS: French health insurance general scheme beneficiaries were identified in the National Health data Information System (Snds) with a selection of information...
May 16, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29715435/serum-fbln1-and-stk31-as-biomarkers-of-colorectal-cancer-and-their-ability-to-noninvasively-differentiate-colorectal-cancer-from-benign-polyps
#2
Mona Mohamed Watany, Nehal Mohamed Elmashad, Rehab Badawi, Nehad Hawash
PURPOSE: The aim of this work is to evaluate Fibulin-1 (FBLN1) and serine threonine kinase-31 (STK31) as colorectal cancer (CRC) tumour markers and their ability to differentiate it from colorectal benign lesions. MATERIAL AND METHODS: In this case-control study, FBLN1 and STK31 serum levels were measured in 120 participants; 49 CRC patients (group I), 26 patients with benign colorectal polyps (group II) and 45 healthy controls (group III). RESULTS: The means of serum FBLN1 were 1...
April 28, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29600229/epidemiology-of-liver-cancer-in-nile-delta-over-a-decade-a-single-center-study
#3
Sherief Abd-Elsalam, Nadia Elwan, Hanan Soliman, Dina Ziada, Walaa Elkhalawany, Marwa Salama, Nehad Hawash, Mona Arafa, Rehab Badawi, Walaa M Shehata, Haidy S Khalil, Nehal Elmashad
Background: In Egypt, there has been a remarkable increase in the proportion of hepatocellular carcinoma (HCC) among chronic liver diseases patients. This rising proportion may be explained by the increasing risk factors as hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection, improvement of the diagnostic tools of HCC as well as the extended survival among patients with cirrhosis to allow time for some of them to develop HCC. The aim of this study was to study the epidemiology of HCC in Nile delta over the last decade...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29582637/swallowing-exercises-will-they-really-help-head-and-neck-cancer-patients
#4
Karim Mashhour, Rehab Abdelkader, Labiba Abdelkader, Shaimaa El Hadary, Wedad Hashem
Purpose: The work was a comparative study, the aim of which is to evaluate the impact of swallowing exercises on swallowing problems among head and neck cancer patients (HNCPs) after CRT. Methods: The sample of 60 HNCPs was equally divided into control and study groups. The investigators met all patients 3 times (before, during and after CRT); swallowing ability was assessed using the Sydney Swallowing Questionnaire (SSQ). The University of Texas, MD Anderson Cancer Center Swallowing Exercise Protocol was explained and demonstrated by the investigators to the study group...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29567429/design-synthesis-and-biological-evaluation-of-novel-1-3-4-trisubstituted-pyrazole-derivatives-as-potential-chemotherapeutic-agents-for-hepatocellular-carcinoma
#5
Marwa F Harras, Rehab Sabour
A series of novel 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their cytotoxic activity against three different cancer cell lines namely HCT116, UO-31 and HepG2. Compounds 3b, 3d, 7b and 9 showed excellent anticancer activity against all the tested cancer cell lines and had better cytotoxic activities than the reference drug, Sorafenib. Therefore, these compounds were chosen to be further evaluated in a panel of HCC cell lines. Among them, 3b and 7b were the most active compounds against HCC cells used here...
March 16, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29546614/the-growth-inhibitory-effect-of-gambogic-acid-on-pancreatic-cancer-cells
#6
Mаhmoud Youns, Abeer ElKhoely, Rehab Kamel
Pancreatic cancer, the fourth most common cause of cancer-related deaths, is one of the most aggressive and devastating human malignancies with increasing incidence worldwide. To date, surgical resection is the only potentially curative therapy available for pancreatic cancer patients. Early diagnosis of pancreatic tumors is difficult, and hence, nearly 80% of patients cannot receive surgical resection. Natural products have always been a vital source for novel compounds for cancer treatment. The naturally occurring prenylated xanthone, gambogic acid, has been previously shown to exert potent anticancer, anti-inflammatory, apoptotic, antiangiogenic, and antioxidant activities...
March 15, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29522280/diagnostic-and-prognostic-value-of-serum-mir-15a-and-mir-16-1-expression-among-egyptian-patients-with-prostate-cancer
#7
Haidy E Zidan, Rehab S Abdul-Maksoud, Walid S H Elsayed, Esam A M Desoky
Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of benign prostatic hyperplasia (BPH), 30 patients with chronic prostatitis and 70 controls. Circulating miR-15a and miR-16-1 expression was detected by real-time polymerase chain reaction. Prostate specific antigen levels were measured by enzyme-linked immunosorbent assay...
May 2018: IUBMB Life
https://www.readbyqxmd.com/read/29481024/prognostic-significance-of-serum-vitamin-d-levels-in-egyptian-females-with-breast-cancer
#8
Abeer Ismail, Rehab El-Awady, Ghada Mohamed, Marwa Hussein, Shimaa Shwaki Ramadan
Objective: To determine the frequency and prognostic significance of vitamin D deficiency in Egyptian women with breast cancer (BC). Methods: This prospective study included 50 women with primary invasive, non-metastatic BC. The serum level of 25-hydroxy vitamin D [25(OH)D was measured by ELISA at diagnosis, before any cancer treatment. Vitamin D deficiency was defined as 25(OH) D<20 ng/mL. Patients were followed up for a median of 30 months (range: 18-48). Results: The median level of 25(OH)D was 29.0 ng/mL (range: 10...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29429370/facile-development-characterization-and-optimization-of-new-metformin-loaded-nanocarrier-system-for-efficient-colon-cancer-adjunct-therapy
#9
Kholoud Arafa, Rehab N Shamma, Omaima N El-Gazayerly, Ibrahim M El-Sherbiny
PURPOSE: Metformin hydrochloride (MF) repurposing as adjuvant anticancer therapy for colorectal cancer (CRC) proved effective. Several studies attempted to develop MF-loaded nanoparticles (NPs), however the entrapment efficiency (EE%) was poor. Thus, the present study aimed at the facile development of a new series of chitosan (CS)-based semi-interpenetrating network (semi-IPN) NPs incorporating Pluronic® nanomicelles as nanocarriers for enhanced entrapment and sustained release of MF for efficient treatment of CRC...
July 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29424355/cytotoxicity-of-propolis-nanopreparations-in-cancer-cell-monolayers-multimode-of-action-including-apoptotsis-and-nitric-oxide-production
#10
Mahmoud S Sherif, Taha A Rehab, Zayed A Hamdia, Vladmir P Torchilin
Natural products are invaluable resource of anticancer drug discovery. They generally viewed as safe but weak, within the framework of nanotechnology, they can serve as template for potent anticancer drugs. We first evaluated the cytotoxic activity of different propolis extracts (water, 70% ethanol, absolute ethanol and hexane) in many cancer cell lines, then the solid nanoparticles from the organic solvent extracts were prepared and their cytotoxicity was evaluated as well. Finally, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes were prepared from the most cytotoxic organic solvent extract and their cytotoxicity was also evaluated...
January 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29327644/evaluation-of-supervised-multimodal-prehabilitation-programme-in-cancer-patients-undergoing-colorectal-resection-a-randomized-control-trial
#11
Guillaume Bousquet-Dion, Rashami Awasthi, Sarah-Ève Loiselle, Enrico M Minnella, Ramanakumar V Agnihotram, Andreas Bergdahl, Francesco Carli, Celena Scheede-Bergdahl
BACKGROUND: Prehabilitation has been previously shown to be more effective in enhancing postoperative functional capacity than rehabilitation alone. The purpose of this study was to determine whether a weekly supervised exercise session could provide further benefit to our current prehabilition program, when comparing to standard post-surgical rehabilitation. METHODS: A parallel-arm single-blind randomized control trial was conducted in patients scheduled for non-metastatic colorectal cancer resection...
January 12, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29326488/resveratrol-prevents-liver-fibrosis-via-two-possible-pathways-modulation-of-alpha-fetoprotein-transcriptional-levels-and-normalization-of-protein-kinase-c-responses
#12
Alyaa Farouk Hessin, Rehab Rehab Hegazy, Azza Ahmed Hassan, Nemat Zakaria Yassin, Sanaa Abdel-Baky Kenawy
OBJECTIVE: Liver fibrosis is a global health problem that causes approximately 1.4 million deaths per year. It is associated with inflammation, oxidative stress, necrosis and ends with cirrhosis, liver cancer, or liver failure. Therefore, the present study was constructed to investigate the protective effect of resveratrol (RVT) on liver fibrosis, focusing on the possible involvement of alpha 1-fetoprotein and protein kinase C signaling. MATERIALS AND METHODS: Rats received thioacetamide (TAA) (200 mg/kg, intraperitoneal) twice weekly, for 4 successive weeks to induce liver fibrosis...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29321821/the-influence-of-glyoxalase-1-gene-polymorphism-on-its-expression-at-different-stages-of-breast-cancer-in-egyptian-women
#13
Rehab S Abdul-Maksoud, Walid Sh Elsayed, Rasha S Elsayed
Aim: To assess the association of GLO1 C332C gene polymorphism with breast cancer risk at different stages of the disease and to investigate the effect of this gene polymorphism on its mRNA expression and enzyme activity. Methods: GLO1 C332C gene polymorphism was analyzed by PCR-RFLP in 100 healthy controls and 200 patients with breast cancer (100 patients with stage I & II and 100 patients with stage III & IV). GLO1 mRNA expression was measured by real time PCR...
November 2017: Genes & Cancer
https://www.readbyqxmd.com/read/29310836/circulating-long-non-coding-rna-malat1-expression-as-molecular-biomarker-in-egyptian-patients-with-breast-cancer
#14
Haidy E Zidan, Rehab A Karam, Omnia S El-Seifi, Tamer M Abd Elrahman
The abnormal contribution of long non-coding RNA (lncRNAs) expression to human tumorigenesis is still a matter of debate. Breast cancer is the most common cancer in females; it represents a terrible problem in our country. The aim of this research was to assess the role of MALAT1, as one of lncRNAs, as a potential biomarker in breast cancer. This study comprised 80 patients with breast cancer and 80 controls. MALAT1 expression was measured by RT-quantitative polymerase chain reaction (qPCR). CA15-3 was estimated using chemiluminescence immunoassay (CLIA)...
January 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29199218/uses-of-cyclohexan-1-4-dione-for-the-synthesis-of-2-amino-4-5-dihydrobenzo-b-thiophen-6-7h-one-derivatives-with-anti-proliferative-and-pim-1-kinase-activities
#15
Rafat Milad Mohareb, Nermeen Saeed Abbas, Rehab Ali Ibrahim
The reaction of cyclohexan-1,4-dione with elemental sulfur and any of the 2-cyano-N-arylacetamide derivatives 2a-c gave the 2-amino-4,5-dihydrobenzo[b]thiophen-6(7H)-one derivatives 3a-c to be used in some heterocyclization reactions. The multicomponent reactions of any of compounds 3a-c with aromatic aldehydes 6a-c and either of malononitrile or ethylcyanoacetate gave the 5,9-dihydro-4H-thieno[2,3-f]chromene derivatives 9a-r, respectively. The anti-proliferative evaluation of the newly synthesized compounds against the six cancer cell lines A549, HT-29, MKN-45, U87MG, SMMC-7721 and H460 showed that the nine compounds 3c, 5c, 9e, 9h, 9i, 9j, 9l, 9q, 11e and 13e with highest cytotoxcity...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29197371/partnering-around-cancer-clinical-trials-pacct-study-protocol-for-a-randomized-trial-of-a-patient-and-physician-communication-intervention-to-increase-minority-accrual-to-prostate-cancer-clinical-trials
#16
Susan Eggly, Lauren M Hamel, Elisabeth Heath, Mark A Manning, Terrance L Albrecht, Ellen Barton, Mark Wojda, Tanina Foster, Michael Carducci, Dina Lansey, Ting Wang, Rehab Abdallah, Narineh Abrahamian, Seongho Kim, Nicole Senft, Louis A Penner
BACKGROUND: Cancer clinical trials are essential for testing new treatments and represent state-of-the-art cancer treatment, but only a small percentage of patients ever enroll in a trial. Under-enrollment is an even greater problem among minorities, particularly African Americans, representing a racial/ethnic disparity in cancer care. One understudied cause is patient-physician communication, which is often of poor quality during clinical interactions between African-American patients and non-African-American physicians...
December 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29193367/cytotoxic-activity-of-carotenoid-rich-fractions-from-haematococcus-pluvialis-and-dunaliella-salina-microalgae-and-the-identification-of-the-phytoconstituents-using-lc-dad-esi-ms
#17
Farouk K El-Baz, Rehab A Hussein, Khaled Mahmoud, Sayeda M Abdo
Microalgae represent a rich source that satisfies the growing need for novel ingredients of nutriceuticals, pharmaceuticals, and food supplements. Haematococcus pluvialis and Dunaliella salina microalgae are isolated from the Egyptian hydro-flora and are reported for their potent antioxidant activities. The cytotoxic activity of different fractions of both microalgae was investigated on 4 cell lines HePG2, MCF7, HCT116, and A549. The carotenoid rich fraction of H. pluvialis showed potent cytotoxic activity against colon cancer cell line and moderate activity against both liver and breast cancer cell lines...
February 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28944220/determinants-for-further-wishes-for-cosmetic-and-reconstructive-interventions-in-1652-patients-with-surgical-treated-carcinomas-of-the-oral-cavity
#18
Henrik Holtmann, Simon Spalthoff, Nils-Claudius Gellrich, Jörg Handschel, Julian Lommen, Norbert R Kübler, Gertrud Krüskemper, Majeed Rana, Karoline Sander
BACKGROUND: The impairment of the appearance is a major problem for patients with carcinomas of the oral cavity. These patients want to recover their preoperative facial appearance. Some do not realize that this is not always possible and hence develop a desire for further cosmetic and reconstructive surgery (CRS) which often causes psychological problems. METHOD: The desire of patients for CRS (N = 410; 26%) has been acquired in this DÖSAK rehab study including multiple reasons such as medical, functional, aesthetic and psychosocial aspects...
December 2017: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28835218/a-parallel-group-randomized-clinical-trial-of-individually-tailored-multidisciplinary-palliative-rehabilitation-for-patients-with-newly-diagnosed-advanced-cancer-the-pal-rehab-study-protocol
#19
Lise Nottelmann, Mogens Groenvold, Tove Bahn Vejlgaard, Morten Aagaard Petersen, Lars Henrik Jensen
BACKGROUND: The effect of early palliative care and rehabilitation on the quality of life of patients with advanced cancer has been only sparsely described and needs further investigation. In the present trial we combine elements of early, specialized palliative care with cancer rehabilitation in a 12-week individually tailored, palliative rehabilitation program initiated shortly after a diagnosis of advanced cancer. METHODS: This single center, randomized, controlled trial will include 300 patients with newly diagnosed advanced cancer recruited from the Department of Oncology, Vejle Hospital...
August 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28751055/deaths-due-to-screenable-cancers-among-people-living-with-hiv-infection-florida-2000-2014
#20
Mary Jo Trepka, Rehab Auf, Kristopher P Fennie, Diana M Sheehan, Lorene M Maddox, Theophile Niyonsenga
INTRODUCTION: Because of antiretroviral therapy, people living with HIV infection are surviving longer and are at higher risk for chronic diseases. This study's objective was to assess the magnitude of deaths due to cancers for which there are screening recommendations for people living with HIV in Florida. METHODS: Florida Department of Health Enhanced HIV/AIDS Reporting System data were matched with Department of Health Vital Records and the National Death Index to identify deaths and their causes through 2014...
November 2017: American Journal of Preventive Medicine
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