keyword
https://read.qxmd.com/read/38481546/eriodictyol-attenuates-doxorubicin-induced-nephropathy-by-activating-the-ampk-nrf2-signalling-pathway
#1
JOURNAL ARTICLE
Rehab Mustafa Badi, Eman Farok Khaleel, Huda Hammed Satti, Rehan Monir
Doxorubicin (DOX), an anthracycline chemotherapy, plays a prominent role in the treatment of various cancers. Unfortunately, its nephrotoxic effects limit its dosing and expose cancer survivors to increased morbidity and mortality. This study examined the nephroprotective effects of eriodictyol, a natural polyphenolic flavanone, in DOX-treated rats and the molecular pathways involved. Forty adult rats were divided into five groups (8/group): Control; eriodictyol (20 mg/kg/day); DOX (2.5 mg/kg, twice/week); DOX + Eriodictyol; and DOX + Eriodictyol + Compound C (CC), an AMPK inhibitor (0...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38415013/editorial-the-oral-gut-axis-from-ectopic-colonization-to-within-host-evolution-of-oral-bacteria
#2
EDITORIAL
Mohamed M H Abdelbary, Rehab Z Abdallah, Hee Sam Na
No abstract text is available yet for this article.
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38342375/synergistic-therapeutic-strategies-and-engineered-nanoparticles-for-anti-vascular-endothelial-growth-factor-therapy-in-cancer
#3
REVIEW
Asmaa F Khafaga, Mohamed M S Gaballa, Reham Karam, Salma A Shoulah, Rehab N Shamma, Norhan E Khalifa, Nehal E Farrag, Ahmed E Noreldin
Angiogenesis is one of the defining characteristics of cancer. Vascular endothelial growth factor (VEGF) is crucial for the development of angiogenesis. A growing interest in cancer therapy is being caused by the widespread use of antiangiogenic drugs in treating several types of human cancer. However, this therapeutic approach can worsen resistance, invasion, and overall survival. As we proceed, refining combination strategies and addressing the constraint of targeted treatments are paramount. Therefore, major challenges in using novel combinations of antiangiogenic agents with cytotoxic treatments are currently focused on illustrating the potential of synergistic therapeutic strategies, alongside advancements in nanomedicine and gene therapy, present opportunities for more precise interference with angiogenesis pathways and tumor environments...
February 9, 2024: Life Sciences
https://read.qxmd.com/read/38289431/an-overview-of-recent-advancements-in-small-molecules-suppression-of-oncogenic-signaling-of-k-ras-an-updated-review
#4
REVIEW
Ahmed Sabt, Haytham O Tawfik, Eman F Khaleel, Rehab Mustafa Badi, Hoda Atef Abdelsattar Ibrahim, Eslam B Elkaeed, Wagdy M Eldehna
RAS (rat sarcoma) oncoproteins are crucial for the growth of some human cancers, including lung, colorectal, and pancreatic adenocarcinomas. The RAS family contains three known human isoforms H(Harvey)-RAS, N(Neuroblastoma)-RAS, and K(Kirsten)-RAS. Mutations in RAS proteins cause up to ~ 30% of cancer cases. For almost 30 years, mutant proteins druggable pockets remained undiscovered, they are nearly identical to their essential, wild-type counterparts and cause cancer. Recent research has increased our knowledge of RAS's structure, processing, and signaling pathways and revealed novel insights into how it works in cancer cells...
January 30, 2024: Molecular Diversity
https://read.qxmd.com/read/38283416/the-level-of-awareness-among-healthcare-practitioners-regarding-the-relationship-between-breast-density-and-breast-cancer
#5
JOURNAL ARTICLE
Renad F Althobaiti, Rehab Brnawe, Orjwan Sendi, Faikah Halawani, Alaa Marzogi
Background Breast cancer is the most prevalent cancer in women, accounting for around 23% of all cancer-related deaths across 140 nations. The awareness about breast density (BD) has a significant impact on early diagnosis of breast cancer. Aim and objective This study aims to assess the awareness of healthcare providers about BD in King Abdullah Medical City. Methods This is an analytical cross-sectional questionnaire-based study among the healthcare practitioners of KAMC in Makkah, Saudi Arabia. Questions measured knowledge about BD and a pass mark indicated participant awareness...
December 2023: Curēus
https://read.qxmd.com/read/38259413/histopathological-findings-in-adult-patients-with-dyspepsia-and-their-association-with-helicobacter-pylori-infection
#6
JOURNAL ARTICLE
Yossef H Ahmed, Rehab A Mohammed, Ibrahim K Alghamdi, Majdah F Alqahtani, Shaden N Alhelali, Intessar Sultan, Mayar I Badawy, Mahmoud M Barakat, Hanaa E Abozeid, Hanan L Mohammed
BACKGROUND: Helicobacter pylori infection is prevalent among Saudi adults and has been linked to gastric cancer and other tumor-like conditions. We aimed to explore the pathological characteristics of endoscopic gastric biopsies among symptomatic adult Saudi patients and their relation to H. pylori infection. RESULTS: Among 151 gastric biopsies, gastritis was detected in 97 (64.2%) cases, chronic active gastritis in 26 patients (17.2%), duodenitis in 20 (13.2%) patients, and total metaplasia in 14 (9...
December 2023: Curēus
https://read.qxmd.com/read/38246945/favipiravir-an-antiviral-drug-in-combination-with-tamoxifen-exerts-synergistic-effect-in-tamoxifen-resistant-breast-cancer-cells-via-htert-inhibition
#7
JOURNAL ARTICLE
Sally A Fahim, Yehia A ElZohairy, Rehab I Moustafa
Tamoxifen (TAM) is one of the most successful treatments for breast cancer; however, TAM resistance continues to be a significant barrier. TAM resistance has been reported to be associated with increased expression of human telomerase reverse transcriptase (hTERT). This enzyme shares structural similarity with RNA-dependent RNA polymerase (RdRp) enzyme of RNA viruses, suggesting that RdRp inhibitors may also inhibit hTERT. Favipiravir (FAV) is an antiviral drug that inhibits RdRp of RNA viruses. Thus, we propose that FAV may also elicit an antitumor effect by suppressing hTERT...
January 22, 2024: Scientific Reports
https://read.qxmd.com/read/38183682/development-of-new-thieno-2-3-d-pyrimidines-as-dual-egfr-and-stat3-inhibitors-endowed-with-anticancer-and-pro-apoptotic-activities
#8
JOURNAL ARTICLE
Heba A Elsebaie, Tarek F El-Moselhy, Eman A El-Bastawissy, Kamel M Elberembally, Rehab Mustafa Badi, Eslam B Elkaeed, Moataz A Shaldam, Wagdy M Eldehna, Haytham O Tawfik
In part due to the resilience of cellular feedback pathways that develop therapeutic resistance to targeting the EGFR alone, using EGFR inhibitors alone was demonstrated to be unsuccessful in clinical trials. The over-activation of the signal transducer/activator of transcription 3 (STAT3) during the administration of an EGFR inhibitor is expected to play a substantial part in the failure and resistance of EGFR inhibitor treatment. Therein, we proposed a hypothesis that induced STAT3-mediated resistance to EGFR inhibition therapy could be addressed by a dual inhibition of EGFR and STAT3 method...
January 4, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38174165/robotic-sigmoidectomy-with-natural-orifice-specimen-extraction-a-single-center-experience
#9
JOURNAL ARTICLE
Naved Salim, Camryn Daidone, Leslie Smith, Ahsan Raza
Background Natural orifice specimen extraction (NOSE) involves the removal of specimens through a naturally occurring orifice, such as the anus, rather than trans-abdominal extraction. NOSE procedures have been shown to significantly reduce postoperative complications and improve healing.  Objective The purpose of this case series is to report the outcomes of 27 patients undergoing sigmoidectomies through natural orifice specimen extraction. Materials and methods We carefully recorded demographic data on age and BMI, as well as operative data on surgical indication, and length of stay...
December 2023: Curēus
https://read.qxmd.com/read/38132365/reduced-psychosocial-well-being-among-the-children-of-women-with-early-onset-breast-cancer
#10
JOURNAL ARTICLE
Antje Schliemann, Alica Teroerde, Bjoern Beurer, Friederike Hammersen, Dorothea Fischer, Alexander Katalinic, Louisa Labohm, Angelika M Strobel, Annika Waldmann
BACKGROUND: Approximately 27% of female breast cancer patients are diagnosed before the age of 55, a group often comprising mothers with young children. Maternal psychosocial well-being significantly impacts these children's psychosocial well-being. This study assesses the well-being of children with mothers who have early-onset breast cancer. METHODS: We examined the eldest child (up to 15 years old) of women with nonmetastatic breast cancer (<55 years old, mean age: 40) enrolled in the mother-child rehab program 'get well together'...
November 21, 2023: Current Oncology
https://read.qxmd.com/read/38118341/analgesic-consumption-in-a-large-sample-of-people-in-musculoskeletal-rehabilitation-a-descriptive-study
#11
JOURNAL ARTICLE
Michel Konzelmann, Philippe Vuistiner, Cyrille Burrus, François Luthi, Bertrand Léger
BACKGROUND: Consumption of opioids is increasing worldwide in people with chronic non-cancer pain, although their effectiveness is debated. OBJECTIVES: The aim of the current study was to evaluate analgesic consumption and its association with different variables (demographic variables, pain, anxiety/depression, catastrophism, and kinesiophobia), in the field of musculoskeletal rehabilitation, where no data are available. METHODS: This was a retrospective study over a period of 8 years on people hospitalised for rehabilitation after injury...
December 19, 2023: Annals of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38004337/an-ethnobotanical-phytochemical-analysis-antimicrobial-and-biological-studies-of-pulicaria-crispa-as-a-graze-promising-shrub
#12
JOURNAL ARTICLE
Mashail N AlZain, Fawziah M Albarakaty, Rehab M A El-Desoukey
Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub Pulicaria crispa (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of Pulicaria crispa aqueous and solvent extracts against a range of standard and animal pathogens...
November 11, 2023: Life
https://read.qxmd.com/read/37997960/biogenic-selenium-nanoparticles-anticancer-antimicrobial-insecticidal-properties-and-their-impact-on-soybean-glycine-max-l-seed-germination-and-seedling-growth
#13
JOURNAL ARTICLE
Asmaa Abdelsalam, Heba El-Sayed, Heba M Hamama, Mostafa Y Morad, Abeer S Aloufi, Rehab M Abd El-Hameed
Selenium nanoparticles (SeNPs) have demonstrated significant potential in a variety of disciplines, making them an extremely desirable subject of research. This study investigated the anticancer and antibacterial properties of my-co-fabricated selenium SeNPs, as well as their effects on soybean ( Glycine max L.) seeds, seedling growth, cotton leafworm ( Spodoptera littoralis ) combat, and plant pathogenic fungi inhibition. SeNPs showed anticancer activity with an IC50 value of 1.95 µg/mL against MCF-7 breast adenocarcinoma cells...
October 24, 2023: Biology
https://read.qxmd.com/read/37982568/pycr1-banf1-and-stard8-expression-in-gastric-carcinoma-a-clinicopathologic-prognostic-and-immunohistochemical-study
#14
JOURNAL ARTICLE
Ola A Harb, Mariem A Elfeky, Mohamed Ali Alabiad, Rehab Hemeda, Ahmed S Allam, Amr T El Hawary, Mohammed Elbaz, Ahmed L Sharaf, Loay M Gertallah, Ahmed Mesbah Abdelaziz, Amany Mohamed Shalaby, Mohammed Alorini, Amar Ibrahim Omer Yahia, Mohamed Negm
BACKGROUND: It will be important to understand the molecular pathways of gastric cancer (GC) occurrence and progression, thus detecting predictive and prognostic biomarkers of GC. Pyrroline-5-carboxylate reductase 1 (PYCR1) was upregulated in many cancers, suggesting its possible roles in carcinogenesis and tumor metastases. Barrier-of-autointegration factor 1 (BANF1) is a protein family that plays essential roles in maintaining the integrity of an intact cellular genome. Rho-GTPs are molecular switches that control many signal transduction pathways in normal cells, including 3 subgroups from 1 to 3 (DLC1-3)...
November 20, 2023: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://read.qxmd.com/read/37893864/assessment-of-psychosocial-correlates-and-associated-factors-of-colorectal-cancer-screening-among-southwestern-saudi-population-a-cross-sectional-study
#15
JOURNAL ARTICLE
Anfal Mohammed Alenezi, Mahadi Mane Hussien Alshariyah, Maryam Nazal Alanazi, Doaa Mazen Abdel-Salam, Ahmad Homoud Al-Hazmi, Ashokkumar Thirunavukkarasu, Ahmed M Alhuwaydi, Rahaf Hamdan Alsabilah, Rehab A Mohamed
Psychosocial correlates are one of the crucial determinants for the uptake of colorectal cancer (CRC) screening by the pre-eligible population. The present study aimed to identify the psychosocial correlates of colorectal cancer screening and determine their associated factors among the Saudi population in the Najran region, Saudi Arabia. Using a validated questionnaire, we assessed five constructs of psychosocial correlates of CRC screening among 790 participants aged 45 years and above. The five constructs were salience and coherence, cancer worries, perceived susceptibility, response efficacy, and social influence...
October 21, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37884117/novel-insights-into-the-augmented-effect-of-curcumin-and-liraglutide-in-ameliorating-cisplatin-induced-nephrotoxicity-in-rats-effects-on-oxidative-stress-inflammation-apoptosis-and-pyroptosis-via-gsk-3%C3%AE
#16
JOURNAL ARTICLE
Rehab M El-Gohary, Asmaa A Ghalwash, Marwa Mahmoud Awad, Rehab Ahmed Ahmed El-Shaer, Sarah Ibrahim, Asmaa Fawzy Eltantawy, Alshaimma Elmansy, Asmaa H Okasha
Cisplatin dose-dependent nephrotoxicity is a major issue limiting its proper use in cancer treatment. Inflammation, redox imbalance, and dysregulated cell death are the most plausible underlying pathomechanics. Curcumin and the glucagon-like peptide-1 receptor agonist, liraglutide, have been investigated in various experimental models for their antioxidant, anti-inflammatory, and cell death modulatory effects. Hence, this work was designed to investigate curcumin and liraglutide nephroprotective effects and how they behave together against cisplatin-induced acute kidney injury (AKI) in an experimental Wistar rat model...
October 24, 2023: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/37866559/advent-in-proteins-nucleic-acids-and-biological-cell-membranes-functionalized-nanocarriers-to-accomplish-active-or-homologous-tumor-targeting-for-smart-amalgamated-chemotherapy-photo-therapy-a-review
#17
REVIEW
Mona M Agwa, Heba Elmotasem, Rehab I Moustafa, Abdallah S Abdelsattar, Mohamed S Mohy-Eldin, Moustafa M G Fouda
Conventional cancer mono-therapeutic approaches including radiotherapy, surgery, and chemotherapy don't always achieve satisfactory outcomes and are frequently associated with significant limitations. Although chemotherapy is a vital intervention, its effectiveness is frequently inadequate and is associated with metastasis, multidrug resistance, off-target effect, and normal cells toxicity. Phototherapies are employed in cancer therapy, encompassing photo-dynamic and photo-thermal therapies which under favorable NIR laser light irradiation initiate the included photosensitizers and photo-thermal agents to generate ROS or thermal heat respectively for cancer cells destruction...
October 20, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37859719/design-synthesis-and-anti-hepatocellular-carcinoma-of-thiopyrimidine-chalcone-hybrids-as-dual-stat3-stat5-inhibitors
#18
JOURNAL ARTICLE
Najla Altwaijry, Rehab Sabour, Mona H Ibrahim, Omkulthom Al Kamaly, Omeima Abdullah, Marwa F Harras
Among the promising therapeutic targets for treating cancer are the continuously active STAT proteins, which are important in the progression of many malignancies. Here, we detail the STAT3/5 inhibitory action and thiopyrimidine/chalcone hybrid design, production, and anti-hepatocellular carcinoma activity. The prepared hybrids were assessed for their cytotoxic effect on HepG2 and Huh7 liver cancer cells. The most active compounds 5e and 5h (IC50 range from 0.55 to 2.58 μM) were further evaluated against normal THLE cells to examine their safety profiles...
October 18, 2023: RSC medicinal chemistry
https://read.qxmd.com/read/37828544/identification-of-3-5-cyano-6-oxo-pyridin-2-yl-benzenesulfonamides-as-novel-anticancer-agents-endowed-with-egfr-inhibitory-activity
#19
JOURNAL ARTICLE
Moataz A Shaldam, Ahmed F Khalil, Hadia Almahli, Maiy Y Jaballah, Andrea Angeli, Eman F Khaleel, Rehab Mustafa Badi, Eslam B Elkaeed, Claudiu T Supuran, Wagdy M Eldehna, Haytham O Tawfik
New 5-cyano-6-oxo-pyridine-based sulfonamides (6a-m and 8a-d) were designed and synthesized to potentially inhibit both the epidermal growth factor receptor (EGFR) and carbonic anhydrase (CA), with anticancer properties. First, the in vitro anticancer activity of each target substance was tested using Henrietta Lacks cancer cell line and M.D. anderson metastasis breast cancer cell line cells. Then, the possible CA inhibition against the human CA isoforms I, II, and IX was investigated, together with the EGFR inhibitory activity, with the most powerful derivatives...
October 12, 2023: Archiv der Pharmazie
https://read.qxmd.com/read/37820770/efficacy-of-the-rehabilitation-planning-consult-for-survivors-of-head-and-neck-cancer-a-phase-ii-randomized-controlled-trial
#20
JOURNAL ARTICLE
Jolie Ringash, Colleen Dunphy, Lisa Avery, Rehab Chahin, Eugene Chang, Aileen M Davis, Jennifer Jones, Rosemary Martino, Lesley Moody, Meredith Giuliani Mbbs, Sara McEwen
BACKGROUND: Survivors of head and neck cancer may have significant lasting impairments and poor access to rehabilitation. To address this, our group developed and evaluated a rehabilitation planning consult (RPC). The RPC is conducted through an initial consultation and a single follow-up session with a rehabilitation professional. During the initial consultation rehabilitation needs are determined and the survivor sets individualized goals and plans. They then implement their plans independently andand are facilitated to evaluate and modify plans as necessary during the follow-up session METHODS: : We employed a waitlist control design to compare proportion of participants attaining a minimally importantly different change in quality of life (QOL) on the SF-36 Physical Health Summary Score (PCS) from baseline to 3 months after study enrollment, between patients randomized to receive (n=77) or wait 14+/-3 weeks to receive (n=76) the RPC...
October 9, 2023: International Journal of Radiation Oncology, Biology, Physics
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