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https://www.readbyqxmd.com/read/28439851/exploring-the-pathophysiology-of-takotsubo-cardiomyopathy
#1
REVIEW
Wengen Chen, Vasken Dilsizian
PURPOSE OF REVIEW: The purpose of this review is to explore the pathophysiology of Takotsubo cardiomyopathy by appraising the interplay between myocardial perfusion, function, metabolism, and, particularly, sympathetic innervation. RECENT FINDINGS: A number of hypotheses have been proposed to explain the pathogenesis of Takotsubo cardiomyopathy, which include (1) catecholamine cardiac toxicity, (2) myocardial sympathetic innervation disruption, (3) coronary vasospasm, (4) myocardial microvascular dysfunction, and (5) aborted myocardial infarction...
June 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28431602/a-comprehensive-analysis-of-the-relationship-between-aca-velocities-and-aca-infarction-following-aneurysmal-subarachnoid-hemorrhage
#2
Michael Moussouttas, Jocelyn Cheng, Joseph Antonakakis, Ameesh Patel, Maria Iuanow
PURPOSE: To evaluate the relationship between anterior cerebral artery (ACA) velocities (and ancillary parameters) and ACA infarction following aneurysmal subarachnoid hemorrhage (aSAH), and to examine the factors that influence velocities. METHODS: Retrospective investigation of 500 consecutive aSAH patients. ACA mean velocities (Vm) were evaluated by daily transcranial ultrasound during the early (days 1-4) and late (days 5-20) periods posthemorrhage. Presence and timing of acute ACA infarctions were identified by serial retrospective review of cerebral computerized tomography (CT) scans...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28427768/syndrome-of-transient-headache-and-neurological-deficits-with-cerebrospinal-fluid-lymphocytosis-handl-in-a-patient-with-confusional-symptoms-diffuse-eeg-abnormalities-and-bilateral-vasospasm-in-transcranial-doppler-ultrasound-a-case-report-and-literature-review
#3
M Hidalgo de la Cruz, R Domínguez Rubio, E Luque Buzo, F Díaz Otero, P Vázquez Alén, J Orcajo Rincón, J Prieto Montalvo, A Contreras Chicote, F Grandas Pérez
INTRODUCTION: HaNDL syndrome (transient headache and neurological deficits with cerebrospinal fluid lymphocytosis) is characterised by one or more episodes of headache and transient neurological deficits associated with cerebrospinal fluid lymphocytosis. To date, few cases of HaNDL manifesting with confusional symptoms have been described. Likewise, very few patients with HaNDL and confusional symptoms have been evaluated with transcranial Doppler ultrasound (TCD). TCD data from patients with focal involvement reveal changes consistent with vasomotor alterations...
April 17, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28424440/gemcitabine-induced-coronary-vasospasm-a-case-report
#4
Mahmut Tuna Katırcıbaşı, Aynur Eken
Gemcitabine is a chemotherapy drug. It is a nucleoside analogue that is usually well tolerated by patients, with myelosuppression (especially thrombocytopenia) as dose-limiting side effect. Other mild to moderate side effects include alopecia, vomiting, nausea, rash, and fever. Coronary ischemia is the most common cardiotoxic effect of gemcitabine, which is due to its antimetabolites. While underlying cause of coronary ischemia following use of gemcitabine is uncertain, endothelial dysfunction and coronary thrombosis are potential explanations...
March 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28416786/basilar-artery-vasospasm-after-pretuncal-non-aneurysmal-subarachnoid-hemorrhage-responding-to-milrinone
#5
Abdulrahman Y Alturki, Abdullah S Alamri, Mohamed M Badawy, Benjamin W Lo
Pretruncal (perimesencephalic) non-aneurysmal subarachnoid hemorrhage (PNSAH) is uniformly associated with an excellent outcome. Although cerebral vasospasm remains a common complication of SAH and constitutes an important predictor of outcome, in the setting of PNSAH, it is extremely rare. Preturnal non-aneurysmal subarac refers to a subset of SAH patients with a characteristic pattern of localized blood on CT of the head, normal cerebral angiography, and benign course when compared to the aneurysmal SAH population...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28415958/glycyrrhizic-acid-exerts-anti-inflammatory-effect-to-improve-cerebral-vasospasm-secondary-to-subarachnoid-hemorrhage-in-a-rat-model
#6
Yi Li, Fengbin Sun, Zhaohui Jing, Xuhui Wang, Xuming Hua, Liang Wan
This study aimed to investigate the therapeutic effect of glycyrrhizic acid (GA) on the cerebral vasospasm (CVS) in a rat subarachnoid hemorrhage (SAH) model and to explore the potential mechanism. A total of 44 healthy male rats were randomly assigned into 3 groups: control group (n = 12), SAH group (n = 16) and GA group (n = 16). No treatment was conducted in control group; in SAH group and GA group, experimental CVS was induced using a double-hemorrhage model and then rats were intraperitoneally injected with normal saline and GA at 10 mg/kg, respectively, once daily...
April 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28414682/a-left-main-coronary-artery-thrombus-presenting-as-a-non-st-elevation-mi
#7
U Ezema, D Daberkow, T Delord, L Guidry, N R Sells
INTRODUCTION: Left main coronary artery (LMCA); thrombus with an acute myocardial infarction identified with coronary angiography is a clinically rare condition with an extremely high mortality rate. We present a case of LMCA thrombus that presented as a non-ST elevation myocardial infarction (NSTEMI);. CASE: A 45-year-old woman with a history of tobacco use and hyperlipidemia presented with a complaint of 10/10 "hard pain" across her chest radiating to her left shoulder and breast which woke her from sleep...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413527/first-report-of-important-causal-relationship-between-the-adamkiewicz-artery-vasospasm-and-dorsal-root-ganglion-cell-degeneration-in-spinal-subarachnoid-hemorrhage-an-experimental-study-using-a-rabbit-model
#8
Osman N Turkmenoglu, Ayhan Kanat, Coskun Yolas, Mehmet Dumlu Aydin, Naci Ezirmik, Cemal Gundogdu
BACKGROUND: The blood supply of the lower spinal cord is heavily dependent on the artery of Adamkiewicz. The goal of this study was to elucidate the effects of lumbar subarachnoid hemorrhage (SAH) on the lumbar 4 dorsal root ganglion (L4DRG) cells secondary to Adamkiewicz artery (AKA) vasospasm. MATERIALS AND METHODS: This study was conducted on 20 rabbits, which were randomly divided into three groups: Spinal SAH (n = 8), serum saline (SS) (SS; n = 6) and control (n = 6) groups...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413524/perioperative-complications-in-endovascular-neurosurgery-anesthesiologist-s-perspective
#9
Megha U Sharma, Pragati Ganjoo, Daljit Singh, Monica S Tandon, Jyotsna Agarwal, Durga P Sharma, Anita Jagetia
BACKGROUND: Endovascular neurosurgery is known to be associated with potentially serious perioperative complications that can impact the course and outcome of anesthesia. We present here our institutional experience in the anesthetic management of various endovascular neurosurgical procedures and their related complications over a 10-year period. METHODS: Data was obtained in 240 patients pertaining to their preoperative status, details of anesthesia and surgery, perioperative course and surgery-related complications...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28409033/aborted-sudden-cardiac-death-in-a-female-patient-presenting-with-takotsubo-like-cardiomyopathy-due-to-epicardial-coronary-vasospasm
#10
Sorin Giusca, Tom Eisele, Peter Nunninger, Benedikt Münz, Grigorios Korosoglou
Takotsubo cardiomyopathy is characterized by apical ballooning of the left ventricle (LV) in the absence of relevant coronary artery stenosis, which typically occurs in elderly women after emotional stress. Catecholamine cardiotoxicity, metabolic disturbance, and coronary microvascular impairment have previously been proposed as underlying pathophysiologic mechanisms of takotsubo cardiomyopathy, whereas myocardial stunning resulting from epicardial coronary artery vasospasm is not generally accepted as a cause of takotsubo cardiomyopathy...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28401260/stent-assisted-coiling-of-wide-neck-bifurcation-aneurysms-with-a-branch-incorporated-in-the-aneurysm-base-long-term-follow-up-in-49-patients-with-53-aneurysms
#11
Boris Lubicz, Ricardo Morais, Pierre-Julien Bruyère, Noémie Ligot, Benjamin Mine
PURPOSE: Wide-neck bifurcation intracranial aneurysms (WNBA) with a branch incorporated in the aneurysm base remain difficult to treat by embolization. We aim to report our long-term follow-up of stent-assisted coiling (SAC) in this subgroup of patients. METHODS: This study was approved by our local ethical committee. A retrospective review of our prospectively maintained database identified all patients treated in our institution by SAC for a WNBA with a branch incorporated in the aneurysm base...
April 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28400792/toll-like-receptor-4-as-a-possible-therapeutic-target-for-delayed-brain-injuries-after-aneurysmal-subarachnoid-hemorrhage
#12
REVIEW
Takeshi Okada, Hidenori Suzuki
Neuroinflammation is a well-recognized consequence of subarachnoid hemorrhage (SAH), and Toll-like receptor (TLR) 4 may be an important therapeutic target for post-SAH neuroinflammation. Of the TLR family members, TLR4 is expressed in various cell types in the central nervous system, and is unique in that it can signal through both the myeloid differentiation primary-response protein 88-dependent and the toll receptor associated activator of interferon-dependent cascades to coordinate the maximal inflammatory response...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28397570/is-intra-arterial-nimodipine-really-beneficial-in-vasospasm-following-aneurysmal-subarachnoid-hemorrhage
#13
Ashwani Kumar, Manoj Phalak
No abstract text is available yet for this article.
April 11, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28386837/effect-of-delayed-onset-prostacyclin-on-markers-of-endothelial-function-and-damage-after-subarachnoid-hemorrhage
#14
Mikkel Gybel-Brask, Rune Rasmussen, Jakob Stensballe, Pär I Johansson, Sisse R Ostrowski
BACKGROUND: Subarachnoid hemorrhage (SAH) is a neurological emergency. Delayed ischemic neurological deficit is one of the main causes of poor outcome after SAH and is probably caused, at least in part, by cerebral vasospasm. The pathophysiology of this is multifaceted, but endothelial damage and activation as well as glycocalyx damage have been implicated. Prostacyclin has been shown to protect damaged and activated endothelium and to facilitate glycocalyx repair. We investigated biomarkers of endothelial activation and damage in patients with SAH randomized to 5 days prostacyclin infusion or placebo...
April 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28383092/effects-of-arginine-vasopressin-and-v1-receptor-antagonist-on-cerebral-vasospasm-secondary-to-subarachnoid-hemorrhage-an-experimental-study
#15
Derviş Mansuri Yilmaz, Ersin Haciyakupoğlu, Serkan Diril, Leman Sencar, Erol Akgül, Sait Polat, Sebahattin Haciyakupoğlu, Ersin Nazlican
AIM: The aim of this study is to examine morphological, radiological and biochemical effects of arginine vasopressin(AV) and AV V1 receptor antagonist cerebral vasospasm(CVS) in rabbit subarachnoid hemorrhage(SAH). MATERIAL AND METHODS: Forty male New Zealand white rabbits were randomly divided to four groups comprising 10 rabbits each. The groups were 1) control, 2) subarachnoid hemorrhage(SAH), 3) SAH+AV application, 4) SAH+V1 antagonist of AV V1 receptor Diameters of the basilar artery of all the groups were measured on angiograms...
March 9, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28382509/predicting-outcome-in-subarachnoid-hemorrhage-sah-utilizing-the-full-outline-of-unresponsiveness-four-score
#16
F A Zeiler, B W Y Lo, E Akoth, J Silvaggio, A M Kaufmann, J Teitelbaum, M West
BACKGROUND: Existing scoring systems for aneurysmal subarachnoid hemorrhage (SAH) patients fail to accurately predict patient outcome. Our goal was to prospectively study the Full Outline of UnResponsiveness (FOUR) score as applied to newly admitted aneurysmal SAH patients. METHODS: All adult patients presenting to Health Sciences Center in Winnipeg from January 2013 to July 2015 (2.5 year period) with aneurysmal SAH were prospectively enrolled in this study. All patients were followed up to 6 months...
April 5, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28379540/hyperglycemia-aggravates-cerebral-vasospasm-after-subarachnoid-hemorrhage-in-a-rat-model
#17
Yu-Hua Huang, Chia-Li Chung, Hung-Pei Tsai, Shu-Chuan Wu, Chih-Zen Chang, Chee-Yin Chai, Tao-Chen Lee, Aij-Lie Kwan
BACKGROUND: Hyperglycemia is common and showed to be risky for poor prognosis in patients with subarachnoid hemorrhage (SAH). However, the causality and mechanism underlying this observation are not well established. OBJECTIVE: To investigate the relationship between hyperglycemia and cerebral vasospasm with its pathogenesis in a rat model of SAH. METHODS: One-shot SAH model was employed in male Sprague-Dawley rats. Hyperglycemia was triggered by intraperitoneal streptozotocin administration (50 mg/kg) 7 days before SAH induction...
March 30, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28377285/reducing-length-of-stay-in-aneurysmal-subarachnoid-hemorrhage-a-three-year-institutional-experience
#18
Ali Alaraj, Ahmed E Hussein, Darian R Esfahani, Sepideh Amin-Hanjani, Victor A Aletich, Fady T Charbel
Hospital length of stay is a common metric of excellence in health care. With limited data evaluating hospital length of stay (LOS) and cost in subarachnoid hemorrhage (SAH), in this study we explore multiple prognostic factors and present our institutional experience in shortening LOS. 345 SAH patients were reviewed over a three year period. Patient demographics, hemorrhage grade, hospital course, hospital costs, and LOS were reviewed. Angiogram-negative SAH, Hunt and Hess (HH) Grade 5, and early mortalities were excluded...
April 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28373616/oculomotor-nerve-palsy-in-a-patient-with-a-ruptured-middle-cerebral-artery-aneurysm
#19
Suguru Yokosako, Yuichiro Kikkawa, Ririko Takeda, Toshiki Ikeda, Hiroki Kurita
We describe a case of acute oculomotor nerve palsy caused by a ruptured middle cerebral artery (MCA) aneurysm. A 59-year-old female presenting with headache and nausea was admitted to our hospital. Her consciousness was alert, and had no other neurological deficit without left oculomotor nerve palsy. A computed tomography (CT) showed SAH extending from left sylvian cistern to basal cistern. CT angiography revealed a left MCA aneurysm which protruded toward internal carotid artery. The patient was successfully treated with surgical clipping...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28365434/ultra-early-angiographic-vasospasm-following-aneurysmal-subarachnoid-hemorrhage-a-systematic-review-and-meta-analysis
#20
REVIEW
Kevin Phan, Justin M Moore, Christoph J Griessenauer, Joshua Xu, Ian Teng, Adam A Dmytriw, Albert H Chiu, Christopher S Ogilvy, Ajith Thomas
OBJECTIVE: Following aneurysmal subarachnoid hemorrhage (aSAH), prognosis is heavily affected by the presence of delayed cerebral ischemia (DCI). There is growing recognition of ultra-early angiographic vasospasm (UEAV) occurring within 48 hours of aSAH, however its relationship with DCI and ultimately prognosis remains unclear. METHODS: Various databases limited to the English language through September 2016 were systematically searched. Eligible studies were those comparing UEAV with control non-UEAV outcomes and follow-up...
March 29, 2017: World Neurosurgery
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