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https://www.readbyqxmd.com/read/29045944/prevalence-estimates-of-rare-congenital-anomalies-by-integrating-two-population-based-registries-in-tuscany-italy
#1
Alessio Coi, Michele Santoro, Anna Pierini, Sonia Marrucci, Federica Pieroni, Fabrizio Bianchi
BACKGROUND/AIMS: Population-based registries play a key role in the epidemiological surveillance of congenital anomalies (CAs). This study is aimed at improving the epidemiological surveillance and providing prevalence estimates of rare CAs using the Registry of Rare Diseases as an added data source to the Registry of Congenital Anomalies. METHODS: Cases of diagnosed rare CAs (2006-2013) were extracted from the Tuscany Registry of Rare Diseases and the Tuscany Registry of Congenital Anomalies in order to set up an integrated dataset...
September 19, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29045765/oral-anti-diabetic-agents-for-women-with-established-diabetes-impaired-glucose-tolerance-or-previous-gestational-diabetes-planning-pregnancy-or-pregnant-women-with-pre-existing-diabetes
#2
REVIEW
Joanna Tieu, Suzette Coat, William Hague, Philippa Middleton, Emily Shepherd
BACKGROUND: While most guidance recommends the use of insulin in women whose pregnancies are affected by pre-existing diabetes, oral anti-diabetic agents may be more acceptable to women. The effects of these oral anti-diabetic agents on maternal and infant health outcomes need to be established in pregnant women with pre-existing diabetes or impaired glucose tolerance, as well as in women with previous gestational diabetes mellitus preconceptionally or during a subsequent pregnancy. OBJECTIVES: To investigate the effects of oral anti-diabetic agents in women with established diabetes, impaired glucose tolerance or previous gestational diabetes who are planning a pregnancy, or pregnant women with pre-existing diabetes, on maternal and infant health...
October 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29045744/developmental-differences-between-schizophrenia-and-bipolar-disorder
#3
Mara Parellada, Sandra Gomez-Vallejo, Monica Burdeus, Celso Arango
Ample evidence supports a neurodevelopmental origin in some cases of schizophrenia (SZ). More inconsistent information is available for bipolar disorder (BD). We herein review studies with a focus on premorbid (adjustment and functionality) and early developmental milestones that include both SZ and BD patients. A search was performed in the PubMed electronic database, retrieving 619 abstracts; 30 were ultimately included in this systematic review. Eight prospective cohorts, 15 retrospective studies, and 7 studies based on national registries...
October 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29045555/reproductive-potential-and-performance-of-fertility-preservation-strategies-in-brca-mutated-breast-cancer-patients
#4
M Lambertini, O Goldrat, A R Ferreira, J Dechene, H A Azim, J Desir, A Delbaere, M-D t'Kint de Roodenbeke, E de Azambuja, M Ignatiadis, I Demeestere
BackgroundPreclinical evidence suggests a possible negative impact of deleterious BRCA mutations on female fertility. However, limited and rather conflicting clinical data are available. This study assessed the reproductive potential and performance of fertility preservation strategies in BRCA-mutated breast cancer patients.Patients and MethodsThis was a retrospective analysis of two prospective studies investigating oocyte cryopreservation and ovarian tissue cryopreservation in newly diagnosed early breast cancer patients...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045548/bold-activity-during-correct-answer-feedback-in-cued-recall-predicts-subsequent-retrieval-performance-an-fmri-investigation-using-a-partial-trial-design
#5
Adrian W Gilmore, Steven M Nelson, Farah Naaz, Ruth A Shaffer, Kathleen B McDermott
Receiving correct answer feedback following a retrieval attempt has proven to be a highly effective means of learning new information, yet the mechanisms behind its efficacy remain poorly understood. Here, fMRI was used to examine how BOLD activity measured during a period of feedback could predict subsequent memory (SM) performance on a final test. Twenty-five human subjects studied pairs of associated words, and were then asked to covertly recall target words in response to provided cues. Correct answer feedback was provided immediately after covert retrieval attempts...
October 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29045499/obstetric-and-psychological-characteristics-of-women-choosing-epidural-analgesia-during-labour-a-cohort-study
#6
Vasilis Sitras, Jūratė Šaltytė Benth, Malin Eberhard-Gran
OBJECTIVES: To investigate the obstetric and psychological characteristics of women who opt to use epidural analgesia (EDA) during labour and the impact of participating in labour preparation courses on women's decisions to use EDA. DESIGN: Longitudinal cohort study. SETTING: Akershus University Hospital, Norway. POPULATION: 2596 women with singleton pregnancies and intended vaginal delivery. METHODS: Data were collected using two self-completed questionnaires at pregnancy weeks 17 and 32...
2017: PloS One
https://www.readbyqxmd.com/read/29045143/reconstruction-of-obliterated-characters-in-polycarbonate-through-spectral-imaging
#7
Cédric Parisien, Gitanjali Kolhatkar, Frank Crispino, André Lajeunesse, Andreas Ruediger
In forensic sciences, there is an increasing demand for non-destructive and reliable methods to retrieve obliterated information in polymers. This study demonstrates a case study for the potential of Raman spectroscopy to reconstruct abraded serial numbers. Residual strain and local variations in the structural arrangement are non-destructively imaged through peak shifts and variations of the full width at half-maximum of specific Raman lines, respectively. We qualitatively validate our approach by successfully recovering an obliterated letter stamped with a pressure of ~170 MPa in a polycarbonate sample, with a subsequent quantitative statistical analysis...
October 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29044940/low-intrapatient-variability-of-histomorphological-findings-in-periprosthetic-tissues-from-revised-metal-ceramic-on-polyethylene-joint-arthroplasties
#8
Jana Vaculova, Jiri Gallo, Pavel Hurnik, Oldrich Motyka, Stuart B Goodman, Jana Dvorackova
The type of tissue response to implant by-products can be determined by examination of periprosthetic tissues. However, little is known about the most suitable location for tissue sampling. The main goal of this study was to evaluate the extent of variability in tissue response in relation to location of tissue sampling, implant fixation, age and sex in total joint arthroplasties with metal-on-polyethylene or ceramic-on-polyethylene bearing pairs. We processed 236 histology slides from 21 patients and focused on the association between the location of tissue samples and histological features...
October 16, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29044905/efficacy-and-safety-of-postoperative-pain-relief-by-parecoxib-injection-after-laparoscopic-surgeries-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Jun-Ming Huang, Zheng-Tao Lv, Ya-Nan Zhang, Wen-Xiu Jiang, Han-Ning Li, Ming-Bo Nie
OBJECTIVE: This study aims to evaluate the efficacy and safety of parecoxib injection in pain relief after laparoscopic surgeries. METHODS: Comprehensive literature search based on four online databases (Pubmed, EMBASE, CENTRAL, ISI Web of Science) was applied to retrieve all related randomized controlled trials (RCTs). Two independent reviewers screened each article for eligibility according to the predetermined inclusion criteria. The Cochrane's Tool was applied to evaluate the methodological quality of included studies...
October 17, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29044734/association-of-androgen-receptor-gene-cag-and-ggn-repeat-polymorphism-with-cryptorchidism-a-meta-analysis
#10
Qi Wang, Xing Ge, Heng-Xue Wang, Qiao-Mei Shi, Zhen Ding, Li-Chun Xu
Researches on association between variations in the androgen receptor (AR) gene repeat polymorphisms and cryptorchidism (CO) had conflicting results. The aim of this meta-analysis was to analyse the potential effects of AR CAG and/or GGN repeat polymorphism on CO. Studies were independently appraised by two investigators on PubMed, Web of Science, EBSCO databases and Foreign Medical Retrieval System. Case-control studies with measurement of CAG and/or GGN repeat length were included. Weighted mean difference (WMD) and 95% confidence intervals (CIs) for the CAG or GGN repeat polymorphism and CO were calculated...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29044591/duodenal-localization-is-a-negative-predictor-of-survival-after-small-bowel-adenocarcinoma-resection-a-population-based-propensity-score-matched-analysis
#11
Alexander Wilhelm, Christian Galata, Ulrich Beutner, Bruno M Schmied, Rene Warschkow, Thomas Steffen, Walter Brunner, Stefan Post, Lukas Marti
BACKGROUND AND OBJECTIVES: This study assessed the influence of tumor localization of small bowel adenocarcinoma on survival after surgical resection. METHODS: Patients with resected small bowel adenocarcinoma, ACJJ stage I-III, were identified from the Surveillance, Epidemiology, and End Results database from 2004 to 2013. The impact of tumor localization on overall and cancer-specific survival was assessed using Cox proportional hazard regression models with and without risk-adjustment and propensity score methods...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29044113/large-second-harmonic-generation-enhancement-in-si3n4-waveguides-by-all-optically-induced-quasi-phase-matching
#12
Adrien Billat, Davide Grassani, Martin H P Pfeiffer, Svyatoslav Kharitonov, Tobias J Kippenberg, Camille-Sophie Brès
Efficient second harmonic generation in integrated platforms is usually achieved by resonant structures, intermodal phase-matching or quasi-phase matching by periodically poling ferroelectric waveguides. However, in all these structures, it is impossible to reconfigure the phase-matching condition in an all-optical way. Here, we demonstrate that a Watt-level laser causes a periodic modification of the second-order susceptibility in a silicon nitride waveguide, allowing for quasi-phase-matching between the pump and second harmonic modes for arbitrary wavelengths inside the erbium band...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29044010/-simple-mechanical-reperfusion-in-acute-myocardial-infarction-determinants-prognostic-implications-and-relation-with-thrombus-histology
#13
Jorge L Szarfer, Alejandro García-Escudero, Federico Blanco, Federico Albornoz, Analía Alonso, Andrea Zappi, Rodrigo Blanco, Gerardo Gigena, Juan Gagliardi
Simple mechanical reperfusion (SMR) is defined as reperfusion achieved after wire insertion at the occluded infarct-related artery in primary angioplasty. The determinants and prognostic implications of SMR and its relationship with the histopathology of the rescued thrombus were evaluated in 601 patients with acute myocardial infarction showing ST elevation and pre-procedural total occlusion of the infarct-related artery (TIMI flow 0). Two groups were considered according to the presence of SMR, defined as the visualization of contrast material after crossing the occlusion with the guide wire...
2017: Medicina
https://www.readbyqxmd.com/read/29043867/risk-factors-for-surgery-in-patients-with-retention-of-endoscopic-capsule
#14
Zemin Han, Weiguang Qiao, Xiuyun Ai, Aimin Li, Zhenyu Chen, Jie Zhang, Tianmo Wan, Xicheng Feng, Side Liu, Fachao Zhi
OBJECTIVES: Surgery is still the main means for removing retained endoscopic capsules. This study intended to evaluate risk factors for surgery in patients with capsule retention. MATERIALS AND METHODS: The data of 5348 consecutive capsule endoscopy examinations were retrospectively analyzed. Cox regression analysis was used to evaluate risk factors. RESULTS: Seventy-seven patients (1.4%) had capsule retention. Spontaneous passage occurred in 16 patients, of which 14 were asymptomatic...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043850/age-adjusted-d-dimer-cut-off-in-the-diagnostic-strategy-for-deep-vein-thrombosis-a-systematic-review
#15
Mads Nybo, Anne-Mette Hvas
BACKGROUND: Studies have indicated that use of an age-adjusted D-dimer cut-off value for patients above 50 years increases utility of the diagnostic strategy for pulmonary embolism. Evidence for the same approach regarding diagnosis of deep vein thrombosis (DVT) is, however, unclear. MATERIALS AND METHODS: A systematic literature review was conducted following the PRISMA Statement guideline to gather the existing knowledge on the use of an age-adjusted D-dimer cut-off in the diagnostic strategy for DVT...
October 18, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29043848/lexical-access-in-a-bilingual-speaker-with-dementia-changes-over-time
#16
Marianne Lind, Hanne Gram Simonsen, Ingeborg Sophie Bjønness Ribu, Bente Ailin Svendsen, Jan Svennevig, Kees de Bot
In this article, we explore the naming skills of a bilingual English-Norwegian speaker diagnosed with Primary Progressive Aphasia, in each of his languages across three different speech contexts: confrontation naming, semi-spontaneous narrative (picture description), and conversation, and at two points in time: 12 and 30 months post diagnosis, respectively. The results are discussed in light of two main theories of lexical retrieval in healthy, elderly speakers: the Transmission Deficit Hypothesis and the Inhibitory Deficit Theory...
October 18, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/29043538/venous-thromboembolism-prophylaxis-in-medically-ill-patients-a-mixed-treatment-comparison-meta-analysis
#17
REVIEW
Majed S Al Yami, Matthew A Silva, Jennifer L Donovan, Abir O Kanaan
The American College of Chest Physicians guidelines recommend unfractionated heparin (UFH), low molecular weight heparins (LMWHs) or fondaparinux for prevention of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), in medically-ill patients. Direct oral anticoagulants (DOACs) have been evaluated relative to enoxaparin for VTE prophylaxis though head-to-head comparisons of these agents are lacking. Therefore, we conducted a mixed treatment comparisons meta-analysis to evaluate the safety and efficacy of established treatments and DOACs for VTE prophylaxis in medically-ill patients...
October 17, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29043523/analysis-of-potential-factors-affecting-allografts-contamination-at-retrieval
#18
A Paolin, C Romualdi, L Romagnoli, D Trojan
The microbiological contamination of retrieved tissues has become a very important topic and it is a critical aspect in the safety of allografts, especially from multi-tissue donors whose tissues are frequently contaminated as a consequence of retrieval. We analysed a total of 10,107 tissues, 8178 musculoskeletal and 1929 cardiovascular tissues, retrieved from 978 multi-tissue donors. Of these, 159 heart-beating donors (HBD) were also organ donors, while the remaining 819 non-heart-beating donors (NHBD) were tissue donors only...
October 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29043292/phyllodes-tumors-with-and-without-fibroadenoma-like-areas-display-distinct-genomic-features-and-may-evolve-through-distinct-pathways
#19
Fresia Pareja, Felipe C Geyer, Rahul Kumar, Pier Selenica, Salvatore Piscuoglio, Charlotte K Y Ng, Kathleen A Burke, Marcia Edelweiss, Melissa P Murray, Edi Brogi, Britta Weigelt, Jorge S Reis-Filho
Breast fibroepithelial lesions (fibroadenomas and phyllodes tumors) are underpinned by recurrent MED12 exon 2 mutations, which are more common in fibroadenomas and benign phyllodes tumors. TERT promoter hotspot mutations have been documented in phyllodes tumors, and found to be more frequent in borderline and malignant lesions. Several lines of evidence suggest that a subset of phyllodes tumors might arise from fibroadenomas. Here we sought to investigate the genetic differences between phyllodes tumors with fibroadenoma-like areas vs...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29043231/voriconazole-plus-caspofungin-for-treatment-of-invasive-fungal-infection-in-children-with-acute-leukemia
#20
Kyu Ho Lee, Young Tae Lim, Jeong Ok Hah, Yu Kyung Kim, Chae Hoon Lee, Jae Min Lee
BACKGROUND: Invasive fungal infections (IFIs) are a life-threatening problem in immunocompromised patients. Despite timely diagnosis and appropriate antifungal therapy, clinical outcomes of IFIs remain unsatisfactory, necessitating treatment with a combination of antifungal agents. Therefore, childhood leukemic patients treated with voriconazole plus caspofungin were evaluated for the safety and efficacy of the combination antifungal therapy to treat IFIs. METHODS: In this retrospective study, medical records were retrieved for patients admitted to the Pediatric Department of Yeungnam University Hospital, Daegu, South Korea, between April 2009 and May 2013...
September 2017: Blood Research
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