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https://www.readbyqxmd.com/read/29458190/cannabinoids-prevent-depressive-like-symptoms-and-alterations-in-bdnf-expression-in-a-rat-model-of-ptsd
#1
Or Burstein, Noa Shoshan, Ravid Doron, Irit Akirav
Posttraumatic stress disorder (PTSD) is a debilitating condition highly comorbid with depression. The endocannabinoid (eCB) system and brain-derived neurotrophic factor (BDNF) are suggestively involved in both disorders. We examined whether cannabinoids can prevent the long-term depressive-like symptoms induced by exposure to the shock and situational reminders (SRs) model of PTSD. The CB1/2 receptor agonist WIN55,212-2 (0.5 mg/kg; i.p.), the fatty acid hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg, i.p.) or vehicle were administered 2 h after severe shock...
February 16, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29458163/dna-adduct-profiling-of-in-vitro-colonic-meat-digests-to-map-red-vs-white-meat-genotoxicity
#2
Lieselot Y Hemeryck, Caroline Rombouts, Ellen De Paepe, Lynn Vanhaecke
The consumption of red meat has been linked to an increased colorectal cancer (CRC) risk. One of the major hypotheses states that heme iron (present in red meat) stimulates the formation of genotoxic N-nitroso compounds (NOCs) and lipid peroxidation products (LPOs). By means of DNA adductomics, chemically induced DNA adduct formation can be mapped in relation to e.g. dietary exposures. In this study, this state-of-the-art methodology was used to investigate alkylation and (lipid per)oxidation induced DNA adduct formation in in vitro red vs...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29457795/random-access-in-large-scale-dna-data-storage
#3
Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez, Sergey Yekhanin, Konstantin Makarychev, Miklos Z Racz, Govinda Kamath, Parikshit Gopalan, Bichlien Nguyen, Christopher N Takahashi, Sharon Newman, Hsing-Yeh Parker, Cyrus Rashtchian, Kendall Stewart, Gagan Gupta, Robert Carlson, John Mulligan, Douglas Carmean, Georg Seelig, Luis Ceze, Karin Strauss
Synthetic DNA is durable and can encode digital data with high density, making it an attractive medium for data storage. However, recovering stored data on a large-scale currently requires all the DNA in a pool to be sequenced, even if only a subset of the information needs to be extracted. Here, we encode and store 35 distinct files (over 200 MB of data), in more than 13 million DNA oligonucleotides, and show that we can recover each file individually and with no errors, using a random access approach. We design and validate a large library of primers that enable individual recovery of all files stored within the DNA...
February 19, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29457675/oocyte-activating-capacity-of-fresh-and-frozen-thawed-spermatids-in-the-common-marmoset-callithrix-jacchus
#4
Narumi Ogonuki, Hiroki Inoue, Shogo Matoba, Yoko Kakino Kurotaki, Hidetoshi Kassai, Yukiko Abe, Erika Sasaki, Atsu Aiba, Atsuo Ogura
The common marmoset (Callithrix jacchus) represents a promising nonhuman primate model for the study of human diseases because of its small size, ease of handling, and availability of gene-modified animals. Here, we aimed to devise reproductive technology for marmoset spermatid injection using immature males for a possible rapid generational turnover. Spermatids at each step could be identified easily by their morphology under differential interference microscopy: thus, early round spermatids had a round nucleus with a few nucleolus-like structures and abundant cytoplasm, as in other mammals...
February 19, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29457635/hand-preference-on-unimanual-and-bimanual-tasks-in-barbary-macaques-macaca-sylvanus
#5
Barbara Regaiolli, Caterina Spiezio, William D Hopkins
The presence of group-level handedness in non-human primates remains controversial, as different studies have produced inconsistent results. Bimanual coordinated tasks have been found to elicit more pronounced hand preferences than simple unimanual tasks. The aim of this study was to examine manual lateralization in a group of 15 Barbary macaques during unimanual and bimanual tasks. In the unimanual task, data on simple food reaching in a foraging context were collected. During the bimanual task, macaques had to use one hand to hold a tube-shaped apparatus while reaching with the other hand to retrieve the food inside it...
February 19, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29457536/heritabilities-and-genetic-trends-for-elbow-score-as-recorded-by-the-new-zealand-veterinary-association-elbow-dysplasia-scheme-1992-2013-in-four-breeds-of-dog
#6
M Soo, N Lopez-Villalobos, A J Worth
AIM: To estimate the heritability of the New Zealand Veterinary Association (NZVA) elbow phenotype, obtain estimated breeding values (EBV) for the worst-elbow score and estimate the genetic trends for this trait in four populous breeds of dogs, using the records from the NZVA Canine Elbow Dysplasia Scheme database (1992-2013). METHODS: Overall, 4,070 elbow records from a pedigree of 11,311 dogs were available for animals scored between 1992 and 2013. The worst elbow score between the left and right elbows was identified for each dog and used for EBV analysis...
February 18, 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29457489/shingrix-the-new-adjuvanted-recombinant-herpes-zoster-vaccine
#7
Stephanie F James, Elias B Chahine, Allana J Sucher, Cassandra Hanna
OBJECTIVES: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles. DATA SOURCES: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. STUDY SELECTION/DATA EXTRACTION: The literature search was limited to human studies published in English...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457220/event-related-potentials-of-emotional-and-neutral-memories-the-role-of-encoding-position-and-delayed-testing
#8
Janine Wirkner, Carlos Ventura-Bort, Paul Schulz, Alfons O Hamm, Mathias Weymar
Previous research found that memory is not only better for emotional information but also for neutral information that has been encoded in the context of an emotional event. In the present ERP study, we investigated two factors that may influence memory for neutral and emotional items: temporal proximity between emotional and neutral items during encoding, and retention interval (immediate vs. delayed). Forty-nine female participants incidentally encoded 36 unpleasant and 108 neutral pictures (36 neutral pictures preceded an unpleasant picture, 36 followed an unpleasant picture, and 36 neutral pictures were preceded and followed by neutral pictures) and participated in a recognition memory task either immediately (N = 24) or 1 week (N = 25) after encoding...
February 19, 2018: Psychophysiology
https://www.readbyqxmd.com/read/29457048/farnesoid-x-receptor-expression-in-microscopic-colitis-a-potential-role-in-disease-etiopathogenesis
#9
Joana Torres, Carolina Palmela, Pedro Gomes de Sena, Maria Pia Costa Santos, Catarina Gouveia, Maria Helena Oliveira, Ana Raquel Henriques, Cecília Rodrigues, Marília Cravo, Paula Borralho
Introduction: Microscopic colitis (MC) is a chronic inflammatory bowel disease with unclear etiology. Bile acid (BA) malabsorption has been described in MC patients. Farnesoid X receptor (FXR) is the main BA receptor; FXR-mediated mechanisms prevent the noxious effects of BA accumulation, preserving the integrity of the intestinal epithelial barrier and preventing intestinal inflammation. Aim: Our aim was to describe the expression of FXR in patients with MC. Methods: Archival formalin-fixed paraffin-embedded samples from the terminal ileum, right and left colon were obtained from patients with MC and matched controls...
January 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29456889/a-bibliometric-analysis-in-gene-research-of-myocardial-infarction-from-2001-to-2015
#10
Huaqiang Zhou, Wulin Tan, Zeting Qiu, Yiyan Song, Shaowei Gao
Objectives: We aimed to evaluate the global scientific output of gene research of myocardial infarction and explore their hotspots and frontiers from 2001 to 2015, using bibliometric methods. Methods: Articles about the gene research of myocardial infarction between 2001 and 2015 were retrieved from the Web of Science Core Collection (WoSCC). We used the bibliometric method and Citespace V to analyze publication years, journals, countries, institutions, research areas, authors, research hotspots, and trends...
2018: PeerJ
https://www.readbyqxmd.com/read/29456834/a-retrospective-report-2003-2013-of-the-complications-associated-with-the-use-of-a-one-man-head-and-tail-rope-recovery-system-in-horses-following-general-anaesthesia
#11
Maria Chie Niimura Del Barrio, Florent David, J M Lynne Hughes, David Clifford, Hans Wilderjans, Rachel Bennett
Background: The mortality rate of horses undergoing general anaesthesia is high when compared to humans or small animal patients. One of the most critical periods during equine anaesthesia is recovery, as the horse attempts to regain a standing position. This study was performed in a private equine practice in Belgium that uses a purpose-designed one-man (head and tail) rope recovery system to assist the horse during the standing process.The main purpose of the retrospective study was to report and analyse complications and the mortality rate in horses during recovery from anaesthesia using the described recovery system...
2018: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29456829/processing-of-acceleration-and-dive-data-on-board-satellite-relay-tags-to-investigate-diving-and-foraging-behaviour-in-free-ranging-marine-predators
#12
Sam L Cox, Florian Orgeret, Mathieu Gesta, Charles Rodde, Isaac Heizer, Henri Weimerskirch, Christophe Guinet
Biologging technologies are changing the way in which the marine environment is observed and monitored. However, because device retrieval is typically required to access the high-resolution data they collect, their use is generally restricted to those animals that predictably return to land. Data abstraction and transmission techniques aim to address this, although currently these are limited in scope and do not incorporate, for example, acceleration measurements which can quantify animal behaviours and movement patterns over fine-scales...
January 2018: Methods in Ecology and Evolution
https://www.readbyqxmd.com/read/29456582/assessing-the-accuracy-of-ultrasound-estimation-of-gestational-age-during-routine-antenatal-care-in-in-vitro-fertilization-ivf-pregnancies
#13
Bridget Knight, Aaron Brereton, Roy J Powell, Helen Liversedge
Introduction: In the UK an accurate gestational age is confirmed by ultrasound measured foetal crown rump length (CRL) at 11 + 2-14 + 1 weeks of gestation. The currently recommended Robinson and Fleming crown rump length reference chart was develop in 1975. Advances in ultrasound technology and standardized crown rump length measurement training could mean this is now out of date. Our study aimed to assess its accuracy in current routine antenatal care. Methods: Retrospective data from 178 IVF pregnancies seen for routine antenatal care at a UK Regional Maternity Unit between 1 January 2006 and 1 January 2016 was retrieved...
February 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29456579/splenic-cyst-as-a-rare-cause-of-fetal-abdominal-cystic-mass-a-multicenter-series-of-nine-cases-and-review-of-the-literature
#14
Waldo Sepulveda, Jose H Ochoa, Daniel Cafici, Amy E Wong, Federico Badano, Elena Andreeva, Elena Y Andreeva
Introduction: Congenital splenic cysts are a rare cause of abdominal cystic masses in the fetus. We describe nine cases of this condition, the largest reported experience to date. A review of the literature for similar cases was also performed. Methods: Cases of congenital splenic cyst were collected from three prenatal diagnostic centers and from a dedicated website of prenatal diagnosis. Information regarding clinical and sonographic findings was obtained by reviewing ultrasound reports and medical records...
February 2018: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29456567/influence-of-blood-glucose-level-on-the-prognosis-of-patients-with-diabetes-mellitus-complicated-with-ischemic-stroke
#15
REVIEW
Xiao-Liu Dong, Fei Guan, Shi-Jun Xu, Li-Xia Zhu, Pan-Pan Zhang, Ai-Bin Cheng, Tie-Jun Liu
We carried out this meta-analysis for the aim of exploring the influence of diabetes mellitus (DM) on the prognosis of patients with ischemic stroke. Relevant studies were identified using computerized databases supplemented with manual search strategies. The included studies were strictly followed the inclusion and exclusion criteria. Case-control studies which related to the influence of DM on the prognosis of patients with ischemic stroke were selected. Statistical analyses were implemented with the STATA version 12...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29456358/surgically-treated-primary-spinal-cord-neoplasms-in-southeastern-nigeria
#16
Mark Chukwunweike Chikani, Okwuoma Okwunodulu, Mathew Mesi, Wilfred C Mezue, Samuel C Ohaegbulam, Chika C Ndubuisi
Background: Primary spinal cord tumors are not as frequently encountered as their cranial counterparts. They could present in such an indolent manner that requires a reasonable index of suspicion for their diagnosis to be considered. Objective: The objective of this study is to analyze the incidence and pattern of primary spinal cord and appendage neoplasms in patients surgically treated in our institution over a decade of practice. Materials and Methods: A retrospective review of clinical, radiological, and histopathology profiles of patients surgically treated for primary spinal cord tumor from 2006 to 2016 was carried out...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456134/parietal-control-network-activation-during-memory-tasks-may-be-associated-with-the-co-occurrence-of-externally-and-internally-directed-cognition-a-cross-function-meta-analysis
#17
Hongkeun Kim
Functional neuroimaging studies on episodic memory retrieval consistently indicated the activation of the precuneus (PCU), mid-cingulate cortex (MCC), and lateral intraparietal sulcus (latIPS) regions. Although studies typically interpreted these activations in terms of memory retrieval processes, resting-state functional connectivity data indicate that these regions are part of the frontoparietal control network, suggesting a more general, cross-functional role. In this regard, this study proposes a novel hypothesis which suggests that the parietal control network plays a strong role in accommodating the co-occurrence of externally directed cognition (EDC) and internally directed cognition (IDC), which are typically antagonistic to each other...
March 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29455782/predictors-of-major-adverse-cardiac-events-following-elective-stenting-of-large-coronary-arteries
#18
Hassan Aghajani, Abdolhakim Alkamel, Akbar Shafiee, Arash Jalali, Younes Nozari, Hamidreza Pourhosseini, Seyed Ebrahim Kassaian, Mojtaba Salarifar, Alimohammad Hajizeinali, Alireza Amirzadegan, Mohammad Alidoosti, Farzad Masoudkabir, Ebrahim Nematipour
OBJECTIVE: Diameter of the affected coronary artery is an important predictor of restenosis and need for revascularization. In the present study, we investigated the frequency and potential risk factors for major adverse cardiac events following elective percutaneous coronary intervention (PCI) and stenting of large coronary arteries. METHODS: We reviewed the data of elective candidates of PCI on a large coronary artery who presented to our center. Demographic, clinical, angiographic and follow-up data of the eligible patients were retrieved from our databank...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455699/existing-approaches-to-chemical-biological-radiological-and-nuclear-cbrn-education-and-training-for-health-professionals-findings-from-an-integrative-literature-review
#19
Mayumi Kako, Karen Hammad, Satoko Mitani, Paul Arbon
OBJECTIVES: This review was conducted to explore the literature to determine the availability, content, and evaluation of existing chemical, biological, radiological, and nuclear (CBRN) education programs for health professionals. METHODS: An integrative review of the international literature describing disaster education for CBRN (2004-2016) was conducted. The following relevant databases were searched: Proquest, Pubmed, Science Direct, Scopus, Journals @ OVID, Google Scholar, Medline, and Ichuschi ver...
February 19, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29455649/molecular-subtyping-of-nasopharyngeal-carcinoma-npc-and-a-microrna-based-prognostic-model-for-distant-metastasis
#20
Lan Zhao, Alvin H W Fong, Na Liu, William C S Cho
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed by the construction of a microRNA (miRNA)-based prognostic model for prediction of distant metastasis. METHODS: We retrieved two NPC datasets: GSE32960 and GSE70970 as training and validation cohorts, respectively. Consensus clustering was employed for cluster discovery, and support vector machine was used to build a classifier...
February 19, 2018: Journal of Biomedical Science
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