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https://www.readbyqxmd.com/read/27071420/a-new-risk-factor-for-traumatic-spinal-cord-injury
#1
Liis Sabre, Jaanus Harro, Diva Eensoo, Mariliis Vaht, Vaike Kabel, Malle Pakkanen, Toomas Asser, Janika Kõrv
Several behavioral factors such as violence, impulsivity, and alcohol-related problems are associated with traumatic spinal cord injury (TSCI). Such factors have been associated with inherently low neuronal serotonergic capacity that in turn is reflected in low activity of monoamine oxidase (MAO) as measured in platelets. The aim of the study was to characterize platelet MAO activity and impulsivity in persons with TSCI. Data were collected from 93 patients with TSCI and compared with 93 age- and gender-matched control subjects...
May 16, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/25022028/the-properties-of-b-form-monoamine-oxidase-in-mitochondria-from-monkey-platelet
#2
Toshio Obata, Masahiro Aomine
The present study was examined the effect of the properties of monkey platelet monoamine oxidase (MAO) based on inhibitor sensitivity. Monkey platelet showed a high MAO activity with beta-phenylethylamine (beta-PEA) as substrate and a very low A-form MAO activity with 5 hydroxytryptamine (5-HT) as substrate. Moreover, monkey platelet MAO was sensitive to the drugs deprenyl as B-form MAO inhibitor and less sensitive to clorgyline and harmaline as A form MAO inhibitor with beta-PEA as the B-form MAO substrate...
0: Research Communications in Molecular Pathology and Pharmacology
https://www.readbyqxmd.com/read/24950453/methamphetamine-and-hiv-1-induced-neurotoxicity-role-of-trace-amine-associated-receptor-1-camp-signaling-in-astrocytes
#3
Irma E Cisneros, Anuja Ghorpade
Methamphetamine (METH) is abused by about 5% of the United States population with approximately 10-15% of human immunodeficiency virus-1 (HIV-1) patients reporting its use. METH abuse accelerates the onset and severity of HIV-associated neurocognitive disorders (HAND) and astrocyte-induced neurotoxicity. METH activates G-protein coupled receptors such as trace amine associated receptor 1 (TAAR1) increasing intracellular cyclic adenosine monophosphate (cAMP) levels in presynaptic cells of monoaminergic systems...
October 2014: Neuropharmacology
https://www.readbyqxmd.com/read/24555226/-some-aspects-of-the-psychostimulant-effect-of-a-phenyl-derivative-of-glutamic-acid-rgpu-135-glutarone-in-experimental-animals
#4
I N Tiurenkov, V V Bagmetova, Iu V Chernysheva, M A Iarkova
Hydrochloride of beta-phenylglutamic acid (RGPU-135, glutarone, neuroglutamine) administered in dosis 13 mg/kg and 26 mg/kg doses increases exercise performance of outbred mice in repeated forced dynamic load test, reduces the intensity of fatigue, and accelerates adaptation to loading. In contrast, beta-phenylethylamine (20 mg/kg) under the same conditions decreases the exercise performance and adaptation capacity and accelerates the development of fatigue. The RGPU-135 compound, similar to typical psychostimulants, in a dose of 26 mg/kg increases the spontaneous motion activity of inbred C57BL/6 mice with the active phenotype of stress response, but not in the BALB/c line mice with the passive phenotype...
2013: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/24501816/-acute-poisoning-with-weight-loss-dietary-supplement-falsely-suggesting-the-use-of-amphetamine
#5
Magdalena Łukasik-Głebocka, Karina Sommerfeld, Artur Tezyk, Barbara Zielińska-Psuja
OBJECTIVE: We report a case of abuse of weight-loss dietary supplement in 27-year-old man, with characteristic for amphetamine sympathomimetic symptoms and positive analysis of this drug in the urine by immunoassay method (FPIA; Axsym, Abbott). However positive result was not confirmed by liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). CASE REPORT: The patient ate nine tablets of the Thermal Pro with declared composition of caffeine (250 mg), bitter orange (200 mg), beta-phenylethylamine (100 mg), willow bark (75 mg), Cayenne pepper (40 mg), 1,3-dimethyloamyloamine (DMAA, 35 mg), gooseberry extract (20 mg), bergamot orange (20 mg), black pepper (5 mg), after two-month period of regular consumption at dose of 2-3 capsules per day...
2013: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/24450221/-comparative-enzymological-study-of-catalytic-properties-of-sturgeon-fish-liver-monoamine-oxidases
#6
O V Iagodina, I N Basova
We performed comparative study of substrate and inhibitor specificity of liver monoamine oxidases (MAO) of the giant sturgeon Huso huso, starred sturgeon Asipenser stellatus, Persian sturgeon Asipenser persicus, and Russian sturgeon Asipenser gueldenstaedtii. Results of the substrate-inhibitor analysis with use of inhibitors chlorgilin and deprenil, as well as of five specific substrates indicate homogeneity of these enzymes. All studied MAO have several orders higher sensitivity to chlorgilin than that to deprenil, the essential interspecies differences being observed...
May 2013: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://www.readbyqxmd.com/read/23789395/-the-reactivity-of-liver-monoamine-oxidase-in-the-ringed-seal-phoca-hispida-ladogensis
#7
(no author information available yet)
The goal of the work consisted in study of substrate and inhibitor specificity of liver monoamine oxidase (MAO) of the freshwater Ladoga subspecies of the ringed seal Phoca hispida ladogensis. The studied enzyme has been established to have large substrate specificity by deaminating, apart from eight classic substrates of MAO of terrestrial mammals, also histamine, the diamine oxidase substrate. It is found out that the deamination rates of benzylamine, beta-phenylethylamine, and N-methylhistamine almost one order higher than rates of deamination of serotonin and noradrenaline...
March 2013: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://www.readbyqxmd.com/read/23662480/-liver-monoamine-oxidase-activity-of-the-lamprey-lampetra-fluviatilis-the-substrate-inhibitory-specificity
#8
(no author information available yet)
Based on data of substrate-inhibitory analysis with use of specific inhibitors--deprenyl, chlorgi-lin--and specific substrates--serotonin, noradrenalin, benzylamine, beta-phenylethylamine, and N-methylhistamine--a suggestion is put forward about the possible existence of one molecular form of monoamine oxidase (MAO) in liver of mature individuals of the European lamprey Lampetra fluviatilis. There are determined kinetic parameters of monoamine oxidase deamination of eight substrates, which indicates the large spectrum of substrate specificity of the lamprey liver MAO...
January 2013: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://www.readbyqxmd.com/read/23013021/-substrate-inhibitory-analysis-of-monoamine-oxidase-from-hepatopancreas-of-the-octopus-bathypolypus-arcticus
#9
I N Basova, O V Iagodina
Study of the substrate-inhibitory specificity of mitochondrial monoamine oxidase (MAO) of hepatopancreas of the octopus Bathypolypus arcticus revealed distinctive peculiarities of catalytic properties of this enzyme. The studied enzyme, on one hand, like the classic MAO of homoiothermal animals, is able to deaminate tyramine, serotonin, benzylamine, tryptamine, beta-phenylethylamine, while, on the other hand, deaminates histamine and does not deaminate putrescine--classic substrates of diamine oxidase (DAO)...
July 2012: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://www.readbyqxmd.com/read/22919677/lactic-acid-bacteria-contribution-to-gut-microbiota-complexity-lights-and-shadows
#10
REVIEW
Enrica Pessione
Lactic Acid Bacteria (LAB) are ancient organisms that cannot biosynthesize functional cytochromes, and cannot get ATP from respiration. Besides sugar fermentation, they evolved electrogenic decarboxylations and ATP-forming deiminations. The right balance between sugar fermentation and decarboxylation/deimination ensures buffered environments thus enabling LAB to survive in human gastric trait and colonize gut. A complex molecular cross-talk between LAB and host exists. LAB moonlight proteins are made in response to gut stimuli and promote bacterial adhesion to mucosa and stimulate immune cells...
2012: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/22593565/detection-and-quantification-of-new-designer-drugs-in-human-blood-part-2-designer-cathinones
#11
Dominic Ammann, Jenna M McLaren, Dimitri Gerostamoulos, Jochen Beyer
In recent years, derivatives of cathinone, a naturally occurring beta-keto phenylethylamine, have entered the illicit drug market. These compounds have been marketed over the internet or in so-called head shops as "legal highs" and have gained popularity among drug users. Numerous fatalities due to the abuse of these drugs in recent years have increased the need for their detection in human blood samples. For detection and determination of 25 designer cathinones and their related ephedrines in blood samples, a liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed using only 100 µL of blood...
July 2012: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/22507691/octopamine-unlike-other-trace-amines-inhibits-responses-of-astroglia-enriched-cultures-to-lipopolysaccharide-via-a-%C3%AE-adrenoreceptor-mediated-mechanism
#12
Giovanni D'Andrea, Antonello D'Arrigo, Fabrizio Facchinetti, Elda Del Giudice, Davide Colavito, Daniele Bernardini, Alberta Leon
Trace amines (TAs), i.e. β-phenylethylamine, tyramine and octopamine, are generally regarded as sympathomimetic compounds with structural and functional analogy with catecholamines. Previous reports have shown particularly high levels of circulating TAs in migraine and cluster headache patients. However, no clues are yet available as to the pathophysiological significance of these alterations. The effect of different TAs on the release of nitric oxide was investigated in rat astroglial cells stimulated with lipopolysaccharide (LPS)...
May 23, 2012: Neuroscience Letters
https://www.readbyqxmd.com/read/22073124/differential-modulation-of-beta-adrenergic-receptor-signaling-by-trace-amine-associated-receptor-1-agonists
#13
Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann
Trace amine-associated receptors (TAAR) are rhodopsin-like G-protein-coupled receptors (GPCR). TAAR are involved in modulation of neuronal, cardiac and vascular functions and they are potentially linked with neurological disorders like schizophrenia and Parkinson's disease. Subtype TAAR1, the best characterized TAAR so far, is promiscuous for a wide set of ligands and is activated by trace amines tyramine (TYR), phenylethylamine (PEA), octopamine (OA), but also by thyronamines, dopamine, and psycho-active drugs...
2011: PloS One
https://www.readbyqxmd.com/read/22032088/the-properties-of-b-form-monoamine-oxidase-in-mitochondria-from-monkey-platelet
#14
Toshio Obata, Masahiro Aomine
The present study was examined the effect of the properties of monkey platelet monoamine oxidase (MAO) based on inhibitor sensitivity. Monkey platelet showed a high MAO activity with beta-phenylethylamine (beta-PEA) as substrate and a very low A-form MAO activity with 5 hydroxytryptamine (5-HT) as substrate. Moreover, monkey platelet MAO was sensitive to the drugs deprenyl as B-form MAO inhibitor and less sensitive to clorgyline and harmaline as A form MAO inhibitor with beta-PEA as the B-form MAO substrate...
2009: Research Communications in Molecular Pathology and Pharmacology
https://www.readbyqxmd.com/read/21061647/-comparative-substrate-inhibitor-analysis-of-liver-monoamine-oxidases-of-minks
#15
COMPARATIVE STUDY
O V Iagodina
Comparative substrate-inhibitor analysis of catalytic properties of liver monoamine oxidases (MAO) was performed in the mature males of the American mink Mustela vison and the European mink Mustela lutreola. The action on the MAO activity was studied of alkaloids of the benzo[c]phenanthridine group: sanguinarine and chelidonine, diisoquinoline alkaloid berberine, medication agents Ukrain and Sanguirythrin as well as derivatives of 2-propylamine: deprenyl and clorgylin. The latter turned out to be irreversible inhibitor of the MAO A form, whereas deprehyl--irreversible inhibitor of the MAO B form in both studied mink species...
September 2010: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://www.readbyqxmd.com/read/21018251/metabolic-studies-on-derivatives-of-beta-phenylethylamine
#16
F H SNYDER, H GOETZE, F W OBERST
No abstract text is available yet for this article.
February 1946: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/20801345/a-4-hydroxy-n-e-2-hydroxyphenyl-methylidene-benzohydrazide-based-sorbent-material-for-the-extraction-hplc-determination-of-biogenic-amines-in-food-samples
#17
Abdassalam Abdelhafiz Tameem, Bahruddin Saad, Ahmad Makahleh, Abdussalam Salhin, Muhammad Idiris Saleh
A sorbent material based on a newly synthesized hydrazone ligand, 4-hydroxy-N'-[(E)-(2-hydroxyphenyl)methylidene]benzohydrazide was prepared by immobilizing the ligand into a silica sol-gel matrix. The capability of the sorbent material for the extraction of seven biogenic amines (BAs), i.e., tryptamine (TRY), beta-phenylethylamine (PEA), putrescine (PUT), cadaverine (CAD), histamine (HIS), tyramine (TYR), and spermidine (SPD) was studied. Under the adopted conditions, the sorbent showed good selectivity towards PUT, CAD, HIS and SPD (% extraction (%E)>96) while %E for TYR, TRY and PEA were 82...
September 15, 2010: Talanta
https://www.readbyqxmd.com/read/20590640/trace-amines-depress-d-2-autoreceptor-mediated-responses-on-midbrain-dopaminergic-cells
#18
Ada Ledonne, Mauro Federici, Michela Giustizieri, Mauro Pessia, Paola Imbrici, Mark J Millan, Giorgio Bernardi, Nicola B Mercuri
BACKGROUND AND PURPOSE: Although trace amines (TAs) are historically considered 'false neurotransmitters' on the basis of their ability to induce catecholamine release, there is evidence that they directly affect neuronal activity via TA receptors, ligand-gated receptor channels and/or sigma receptors. Here, we have investigated the effects of two TAs, tyramine (TYR) and beta-phenylethylamine (beta-PEA), on electrophysiological responses of substantia nigra pars compacta (SNpc) dopaminergic cells to the D(2) receptor agonist, quinpirole...
July 2010: British Journal of Pharmacology
https://www.readbyqxmd.com/read/20586417/novel-elisas-for-screening-of-the-biogenic-amines-gaba-glycine-beta-phenylethylamine-agmatine-and-taurine-using-one-derivatization-procedure-of-whole-urine-samples
#19
Han Huisman, Paul Wynveen, Mikaela Nichkova, Gottfried Kellermann
The inhibitory neurotransmitters GABA, glycine and agmatine and neuromodulators beta-phenylethylamine (beta-PEA) and taurine are important biogenic amines of the sympathetic and parasympathetic nervous systems in the body. Abnormalities in the metabolism of these biomarkers have been implicated in a vast number of neurological diseases. Novel competitive immunoassays, using one unique whole urine derivatization procedure applicable for all five biomarkers, have been developed. The determination of these biomarkers was highly reproducible: the coefficient of variance of inter- and intra-assay variation is between 3...
August 1, 2010: Analytical Chemistry
https://www.readbyqxmd.com/read/20583578/-comparative-study-of-substrate-and-inhibitory-specificity-of-monoamine-oxidase-in-the-optic-ganglia-of-squids
#20
COMPARATIVE STUDY
O V Iagodina
Comparative study of substrate specificity of monoamine oxidase (MAO) of optic ganglia of the Pacific squid Todarodes pacificus and the Commander squid Berryteuthis magister has been carried out. The enzyme of the Pacific squid, unlike that of the Commander squid, has been established to be able to deaminate not only tyramine, tryptamine, serotonin, benzylamine, and beta-phenylethylamine, but also histamine--substrate of diamine oxidase (DAO). In relation to all studied substrates, the MAO activity of optic ganglia of T...
May 2010: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
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