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https://www.readbyqxmd.com/read/28722144/mechanisms-involved-in-hypersensitivity-reactions-to-polysulfone-hemodialysis-membranes
#1
Aranzazu Rodríguez-Sanz, Rafael Sánchez-Villanueva, Javier Domínguez-Ortega, Ana-María Fiandor, María-Paz Ruiz, Filomena Trocoli, Rafael Díaz-Tejeiro, Carlos Cadenillas, Elena González, Virginia Martínez, Margarita López-Trascasa, Santiago Quirce, Rafael Selgas, Teresa Bellón
Several cases of patients with anaphylactic or systemic hypersensitivity reactions to polysulfone (PS) hemodialysis (HD) membranes and tolerance to cellulose triacetate (CTA) membranes have recently been reported. To investigate the mechanisms involved in PS hypersensitivity, basophil, T cell, and complement activation were analyzed in acute-phase samples from two patients with systemic reactions to PS-based membranes. Basophil and T cell activation, as well as higher serum tryptase levels were detected in acute-phase samples compared with basal levels...
July 19, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28722113/specialised-stomatal-humidity-responses-underpin-ecological-diversity-in-c3-bromeliads
#2
Jamie Males, Howard Griffiths
The Neotropical Bromeliaceae display an extraordinary level of ecological variety, with species differing widely in habit, photosynthetic pathway, and growth form. Divergences in stomatal structure and function, hitherto understudied in treatments of bromeliad evolutionary physiology, could have been critical to the generation of variety in ecophysiological strategies among the bromeliads. Since humidity is a key factor in bromeliad niches, we focussed on stomatal responses to vapour pressure deficit (VPD)...
July 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28720541/biological-sources-of-variation-of-serum-adiponectin-among-healthy-individuals-in-comparison-with-related-nutritional-and-inflammatory-markers
#3
Yoshihisa Shimizu, Kiyoshi Ichihara, Katsuyuki Nakajima
BACKGROUND: Serum adiponectin (AN) is a nutritional and inflammatory marker of various diseases. Its biological sources of variation (SVs) have been widely evaluated in, but its relationships with other related markers remain to be studied comprehensibly by use of multivariate analyses including factor analysis. METHODS: Serum specimens from 752 well-defined healthy subjects (295 males; 457 females) obtained from Japan, Hong Kong, Taiwan, and Vietnam were tested for total AN (tAN) and high-molecular-weight AN (hmAN) together with 71 major analytes...
July 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28720181/computerized-tests-of-team-performance-and-crew-coordination-suitable-for-military-aviation-settings
#4
Ben D Lawson, Thomas W Britt, Amanda M Kelley, Jeremy R Athy, Shauna M Legan
INTRODUCTION: The coordination of team effort on shared tasks is an area of inquiry. A number of tests of team performance in challenging environments have been developed without comparison or standardization. This article provides a systematic review of the most accessible and usable low-to-medium fidelity computerized tests of team performance and determines which are most applicable to military- and aviation-relevant research, such as studies of group command, control, communication, and crew coordination...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28719271/trachomatous-scar-ranking-a-novel-outcome-for-trachoma-studies
#5
Angela Baldwin, Alexander M Ryner, Zerihun Tadesse, Ayalew Shiferaw, Kelly Callahan, Dionna M Fry, Zhaoxia Zhou, Thomas M Lietman, Jeremy D Keenan
AbstractWe evaluated a new trachoma scarring ranking system with potential use in clinical research. The upper right tarsal conjunctivas of 427 individuals from Ethiopian villages with hyperendemic trachoma were photographed. An expert grader first assigned a scar grade to each photograph using the 1981 World Health Organization (WHO) grading system. Then, all photographs were ranked from least (rank = 1) to most scarring (rank = 427). Photographic grading found 79 (18.5%) conjunctivae without scarring (C0), 191 (44...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717312/effect-of-high-and-low-roughage-total-mixed-ration-diets-on-rumen-metabolites-and-enzymatic-profiles-in-crossbred-cattle-and-buffaloes
#6
S K Sinha, V B Chaturvedi, Putan Singh, L C Chaudhary, Mayukh Ghosh, Swati Shivani
AIM: A comparative study was conducted on crossbred cattle and buffaloes to investigate the effect of feeding high and low roughage total mixed ration (TMR) diets on rumen metabolites and enzymatic profiles. MATERIALS AND METHODS: Three rumen-fistulated crossbred cattle and buffalo were randomly assigned as per 3×3 switch over design for 21-days. Three TMR diets consisting of concentrate mixture, wheat straw and green maize fodder in the ratios of (T1) 60:20:20, (T2) 40:30:30, and (T3) 20:40:40, respectively, were fed to the animals ad libitum...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28717060/clinical-data-analysis-of-genotypes-and-phenotypes-of-deafness-gene-mutations-in-newborns-a-retrospective-study
#7
Yating Du, Lihui Huang, Xueyao Wang, Qingjia Cui, Xiaohua Cheng, Liping Zhao, Tingting Ni
We retrospectively analyzed newborns with deafness gene mutations and summarized the relationship between genotype and phenotype to provide a basis for genetic counseling. We studied 582 subjects positive for deafness gene mutations that were treated in the otology outpatient department of Beijing Tongren Hospital, Capital Medical University, between April 2012 and April 2016. The subjects were divided into 3 categories: a diagnosed group (group A), which was further subdivided into subgroups A1 (homozygous and compound heterozygous GJB2 mutations) and A2 (homozygous and compound heterozygous SLC26A4 mutations); a drug-induced deafness group (group B, mitochondrial (Mt) gene mutations); and a mutation carrier group (group C), which was further subdivided into the subgroups C1 (GJB2 heterozygous mutations), C2 (SLC26A4 heterozygous mutations), C3 (GJB3 heterozygous mutations), and C4 (double gene mutations)...
July 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28717026/acquisition-and-metabolism-of-carbon-in-the-ochrophyta-other-than-diatoms
#8
REVIEW
John A Raven, Mario Giordano
The acquisition and assimilation of inorganic C have been investigated in several of the 15 clades of the Ochrophyta other than diatoms, with biochemical, physiological and genomic data indicating significant mechanistic variation. Form ID Rubiscos in the Ochrophyta are characterized by a broad range of kinetics values. In spite of relatively high K0.5CO2 and low CO2 : O2 selectivity, diffusive entry of CO2 occurs in the Chrysophyceae and Synurophyceae. Eustigmatophyceae and Phaeophyceae, on the contrary, have CO2 concentrating mechanisms, usually involving the direct or indirect use of [Formula: see text] This variability is possibly due to the ecological contexts of the organism...
September 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28716013/long-term-renal-survival-of-%C3%AE-3-heavy-chain-deposition-disease-a-case-report
#9
Takayuki Katsuno, Shige Mizuno, Masatsuna Mabuchi, Naotake Tsuboi, Atsushi Komatsuda, Shoichi Maruyama
BACKGROUND: Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the non-amyloid deposition of monoclonal immunoglobulin fragments in the basement membranes. Heavy chain deposition disease (HCDD) is a type of MIDD. HCDD is an extremely rare disease, and only three cases have been reported in Japan up to the present. The prognosis of HCDD is very poor, and optimal treatment has not been established. Only a few cases of HCDD with favorable long-term renal prognosis have been reported to date...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28715298/assessment-of-in%C3%A2-vivo-3d-kinematics-of-cervical-spine-manipulation-influence-of-practitioner-experience-and-occurrence-of-cavitation-noise
#10
Bernard Van Geyt, Pierre-Michel Dugailly, Paul Klein, Yves Lepers, Benoît Beyer, Véronique Feipel
BACKGROUND: Investigations on 3D kinematics during spinal manipulation are widely reported for assessing motion data, task reliability and clinical effects. However the link between cavitation occurrence and specific kinematics remains questionable. OBJECTIVES: This paper investigates the 3D head-trunk kinematics during high velocity low amplitude (HVLA) manipulation for different practitioners with respect to the occurrence of cavitation. METHODS: Head-trunk 3D motions were sampled during HVLA manipulation in twenty asymptomatic volunteers manipulated by four practitioners with different seniority (years of experience)...
April 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28715112/effects-of-free-air-carbon-dioxide-enrichment-face-on-nitrogen-assimilation-and-growth-of-winter-wheat-under-nitrate-and-ammonium-fertilization
#11
Markus Dier, Rieke Meinen, Martin Erbs, Lena Kollhorst, Christin-Kirsty Baillie, David Kaufholdt, Martin Kücke, Hans-Joachim Weigel, Christian Zörb, Robert Hänsch, Remy Manderscheid
A two year Free Air CO2 Enrichment (FACE) experiment was conducted with winter wheat. It was investigated whether elevated atmospheric CO2 concentrations (e[CO2 ]) inhibit nitrate assimilation and whether better growth and nitrogen acquisition under e[CO2 ] can be achieved with an ammonium based fertilization as it was observed in hydroponic culture with wheat. Under e[CO2 ] a decrease of nitrate assimilation has been discussed as the cause for observed declines in protein concentration in C3 cereals. Wheat was grown under ambient [CO2 ] and e[CO2 ] (600 ppm) with three levels (deficiency, optimal and excessive) of nitrate based fertilization (calcium ammonium nitrate; CAN) or with optimal ammonium based fertilization...
July 17, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28714545/focal-hemodynamic-responses-in-the-stimulated-hemisphere-during-high-definition-transcranial-direct-current-stimulation
#12
Makii Muthalib, Pierre Besson, John Rothwell, Stéphane Perrey
OBJECTIVE: High-definition transcranial direct current stimulation (HD-tDCS) using a 4 × 1 electrode montage has been previously shown using modeling and physiological studies to constrain the electric field within the spatial extent of the electrodes. The aim of this proof-of-concept study was to determine if functional near-infrared spectroscopy (fNIRS) neuroimaging can be used to determine a hemodynamic correlate of this 4 × 1 HD-tDCS electric field on the brain. MATERIALS AND METHODS: In a three session cross-over study design, 13 healthy males received one sham (2 mA, 30 sec) and two real (HD-tDCS-1 and HD-tDCS-2, 2 mA, 10 min) anodal HD-tDCS targeting the left M1 via a 4 × 1 electrode montage (anode on C3 and 4 return electrodes 3...
July 17, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28712854/c5-nephritic-factors-drive-the-biological-phenotype-of-c3-glomerulopathies
#13
Maria-Chiara Marinozzi, Sophie Chauvet, Moglie Le Quintrec, Morgane Mignotet, Florent Petitprez, Christophe Legendre, Mathilde Cailliez, Georges Deschenes, Michel Fischbach, Alexandre Karras, Francois Nobili, Christine Pietrement, Marie-Agnes Dragon-Durey, Fadi Fakhouri, Lubka T Roumenina, Veronique Fremeaux-Bacchi
C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis, are associated with genetic and acquired dysregulation of the C3 convertase alternative pathway of complement. The potential role of the activation of the C5 convertase has not been studied extensively. Here we analyzed IgG samples from patients with C3 Glomerulopathies to identify circulating autoantibodies that stabilize the C3 alternative pathway (C3 Nephritic Factors) as well as C5 convertases (C5 Nephritic Factors), thus preventing decay of these enzyme complexes...
July 13, 2017: Kidney International
https://www.readbyqxmd.com/read/28712554/improved-coverage-of-naphthenic-acid-fraction-compounds-by-comprehensive-two-dimensional-gas-chromatography-coupled-with-high-resolution-mass-spectrometry
#14
David T Bowman, Karl J Jobst, Xavier Ortiz, Eric J Reiner, Lesley A Warren, Brian E McCarry, Greg F Slater
This study reports the first application of comprehensive two-dimensional gas chromatography coupled to a high-resolution quadrupole time-of-flight mass spectrometer (GC×GC/HRQTOF-MS) for the characterization of naphthenic acid fraction compounds (NAFCs) from the Alberta Oil Sands. High resolution mass spectrometry (HRMS) significantly increased the coverage of NAFCs in the mixture and allowed the differentiation of NAFCs from several chemical classes. It was demonstrated that GC×GC, in combination with the high mass accuracy and precision of the HRQTOF-MS, could distinguish chemical species with the C3 vs SH4 mass split at a much lower resolving power than required with direct infusion experiments...
July 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28711563/application-of-neurite-orientation-dispersion-and-density-imaging-or-diffusion-tensor-imaging-to-quantify-the-severity-of-cervical-spondylotic-myelopathy-and-assess-postoperative-neurological-recovery
#15
Genki Okita, Tetsuro Ohba, Tomohiro Takamura, Shigeto Ebata, Ryo Ueda, Hiroshi Onishi, Hirotaka Haro, Masaaki Hori
BACKGROUND CONTEXT: Surgical outcome and the severity of cervical spondylotic myelopathy (CSM) are unpredictable and cannot be estimated by conventional anatomical MRI. The utility of diffusion tensor imaging (DTI) to quantify the severity of CSM and assess postoperative neurological recovery has been investigated. However, whether conventional DTI should be applied in a clinical setting remains controversial. Neurite orientation dispersion and density imaging (NODDI) is a recently introduced model-based diffusion-weighted MRI technique that quantifies specific microstructural features related directly to neuronal morphology...
July 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28710534/double-plating-of-intra-articular-multifragmentary-c3-type-distal-femoral-fractures-through-the-anterior-approach
#16
Mohamed A Imam, Ahmed Torieh, Ahmed Matthana
INTRODUCTION: In this prospective case series, we report a mean of 12-month follow-up of the utilization of a dual plating of distal femoral fractures. Our technique included a lateral distal femoral locked plate with a low-contact-locked medial plate and bone graft through an extended medial parapatellar anterior approach for the fixation of C3-type distal femoral fractures. PATIENTS AND METHODS: Sixteen patients (11 males and 5 females) presented with supracondylar femoral fracture type C3, according to Müller long-bone classification system and its revision OA/OTA classification...
July 14, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28710441/igg3-antigen-complexes-are-deposited-on-follicular-dendritic-cells-in-the-presence-of-c1q-and-c3
#17
Lu Zhang, Zhoujie Ding, Birgitta Heyman
IgG3, passively administered together with small proteins, induces enhanced primary humoral responses against these proteins. We previously found that, within 2 h of immunization, marginal zone (MZ) B cells capture IgG3-antigen complexes and transport them into splenic follicles and that this requires the presence of complement receptors 1 and 2. We have here investigated the localization of IgG3 anti-2, 4, 6-trinitrophenyl (TNP)/biotin-ovalbumin-TNP immune complexes in the follicles and the involvement of classical versus total complement activation in this process...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710284/the-neuronal-protein-neurexin-directly-interacts-with-the-scribble-pix-complex-to-stimulate-f-actin-assembly-for-synaptic-vesicle-clustering
#18
Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie
Synaptic vesicles (SVs) form distinct pools at synaptic terminals, and this well-regulated separation is necessary for normal neuro-transmission. However, how SV cluster in particular synaptic compartments to maintain normal neurotransmitter release remains a mystery. The presynaptic protein Neurexin (NRX) plays a significant role in synaptic architecture and function, and some evidences suggest that NRX is associated with neurological disorders, including autism spectrum disorders. However, the role of NRX in SV clustering is unclear...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28708938/interactions-between-quinolones-and-bacillus-anthracis-gyrase-and-the-basis-of-drug-resistance
#19
Rachel E Ashley, Robert Hunter Lindsey, Sylvia A McPherson, Charles L Turnbough, Robert J Kerns, Neil Osheroff
Gyrase appears to be the primary cellular target for quinolone antibacterials in multiple pathogenic bacteria, including Bacillus anthracis, the causative agent of anthrax. Given the significance of this type II topoisomerase as a drug target, it is critical to understand how quinolones interact with gyrase and how specific mutations lead to resistance. However, these important issues have yet to be addressed for a canonical gyrase. Therefore, we utilized a mechanistic approach to characterize quinolone interactions with wild-type B...
July 14, 2017: Biochemistry
https://www.readbyqxmd.com/read/28707819/catalytic-regio-and-enantioselective-4-2-annulation-reactions-of-non-activated-allenes-by-a-chiral-cationic-indium-complex
#20
Le Wang, Jian Lv, Long Zhang, Sanzhong Luo
Regio- and enantioselective [4+2] annulation between ,γ-unsaturated -keto esters and non-activated allenes has been achieved by a chiral cationic indium(III)/phosphate catalyst. The reaction affords the corresponding C3-selective dihydropyrans in good yields and with high enantioselectivities (up to 99% ee).
July 14, 2017: Angewandte Chemie
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