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https://www.readbyqxmd.com/read/29151252/dominant-c3-glomerulopathy-new-roles-for-an-old-actor-in-renal-pathology
#1
REVIEW
Nicola Pirozzi, Antonella Stoppacciaro, Paolo Menè
Recently, a number of reports have described dominant C3 deposits in renal biopsies of patients with infection-related glomerulonephritis (GN). While acute post-infectious GN and membranoproliferative GN are commonly characterized by immune deposits containing C3 and/or C4, the absence of immunoglobulin (Ig) and/or immune complexes at light or electron microscopy is a rather unusual observation. Dominant C3 deposition is believed to result from the alternative pathway of complement activation via the C3bBb "tickover" convertase...
November 18, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29150244/proteomic-analysis-of-follicular-fluid-from-tropically-adapted-goats
#2
Alexandre R Paula Junior, Mauricio F van Tilburg, Marina D P Lobo, Ana C O Monteiro-Moreira, Renato A Moreira, Carlos H S Melo, Joanna M G Souza-Fabjan, Airton A Araújo, Luciana M Melo, Dárcio I A Teixeira, Arlindo A Moura, Vicente J F Freitas
The present study was conducted to characterize the major proteome of ovarian follicular fluid from locally-adapted, "Canindé" goats in the northeast of Brazil. Eight estrous cycling goats received a hormonal treatment consisting of medroxyprogesterone acetate, D-cloprostenol and FSH. Fluid was collected by laparoscopy from small (<3mm), medium (3-4mm) and large (>4mm) follicles and then, proteins were analyzed by 2-D SDS-PAGE and tandem mass spectrometry. Thirty-six proteins were identified in the goat follicular fluid, including albumin, immunoglobulins, ceruloplasmin, complement factor B, alpha-1B-glycoprotein precursor, serotransferrin, complement C3 and serpins, among others...
November 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29148887/wild-birds-as-a-potential-source-of-known-and-novel-multilocus-sequence-types-of-antibiotic-resistant-enterococcus-faecalis
#3
Dagmara Stępień-Pyśniak, Tomasz Hauschild, Anna Nowaczek, Agnieszka Marek, Marta Dec
We assessed the antibiotic resistance and genetic diversity of 27 Enterococcus faecalis isolates from 25 wild bird species in Poland. Resistance to lincomycin (100%) was most common followed by tetracycline (48%), erythromycin (44%), and ciprofloxacin (22%). High-level resistance to streptomycin and kanamycin was observed in 19 and 15% of isolates, respectively. One isolate (4%) exhibited low-level resistance to penicillin and vancomycin, and all isolates were susceptible to gentamicin and chloramphenicol. Antibiotic resistance was linked to the tet(M), tet(L), erm(A), erm(B), msr(A/B), ant(6)-Ia, and aph(3')-IIIa genes...
November 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29148251/the-enzymatic-detoxification-of-the-mycotoxin-deoxynivalenol-identification-of-depa-from-the-don-epimerization-pathway
#4
Jason Carere, Yousef I Hassan, Dion Lepp, Ting Zhou
The biological detoxification of mycotoxins, including deoxynivalenol (DON), represents a very promising approach to address the challenging problem of cereal grain contamination. The recent discovery of Devosia mutans 17-2-E-8 (Devosia spp. 17-2-E-8), a bacterial isolate capable of transforming DON to the non-toxic stereoisomer 3-epi-deoxynivalenol, along with earlier reports of bacterial species capable of oxidizing DON to 3-keto-DON, has generated interest in the possible mechanism and enzyme(s) involved...
November 17, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29146705/complement-c3-is-a-novel-modulator-of-the-anti-fviii-immune-response
#5
Julie Rayes, Mathieu Ing, Sandrine Delignat, Ivan Peyron, Laurent Gilardin, Carl-Wilhelm Vogel, David C Fritzinger, Véronique Frémeaux-Bacchi, Srinivas V Kaveri, Lubka T Roumenina, Sébastien Lacroix-Desmazes
Development of neutralizing antibodies against therapeutic factor VIII (FVIII) is the most serious complication of the treatment of hemophilia A. Increasing evidence shows the multifactorial origin of the anti-FVIII immune response, combining both genetic and environmental factors. While a role for the complement system on innate as well as adaptive immunity has been documented, the implication of complement activation on the onset of the anti-FVIII immune response is unknown. Here, using in vitro assays for FVIII endocytosis by human monocyte-derived dendritic cells and presentation to T cells, as well as animal models of in vivo complement depletion, we show a novel role for complement C3 in enhancing the immune response against therapeutic FVIII...
November 16, 2017: Haematologica
https://www.readbyqxmd.com/read/29146446/hericium-caput-medusae-bull-fr-pers-polysaccharide-enhance-innate-immune-response-immune-related-genes-expression-and-disease-resistance-against-aeromonas-hydrophila-in-grass-carp-ctenopharyngodon-idella
#6
Changlong Gou, Jiazhen Wang, Yuqiong Wang, Wenlong Dong, Xiaofeng Shan, Yujie Lou, Yunhang Gao
The objective was to add 0, 400, 800 or 1200 mg/kg of Hericium caput-medusae polysaccharide (HCMP) to the basal diet of grass carp (Ctenopharyngodon idella) and determine effects on humoral innate immunity, expression of immune-related genes and disease resistance. Adding HCMP enhanced (P < 0.05) bactericidal activity at 1, 2 and 3 weeks and also lysozyme activity, complement C3, and SOD activity at 2 and 3 weeks. Supplementing 800 or 1200 mg/kg of HCMP for 2 or 3 weeks increased (P < 0.05) serum concentrations of total protein, albumin and globulin...
November 13, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29145838/mri-characteristics-for-phantom-scratching-in-canine-syringomyelia
#7
Zoe R Nalborczyk, Angus K McFadyen, Jelena Jovanovik, Anna Tauro, Colin J Driver, Noel Fitzpatrick, Susan P Knower, Clare Rusbridge
BACKGROUND: A classic sign of canine syringomyelia (SM) is scratching towards one shoulder. Using magnetic resonance imaging (MRI) we investigate the spinal cord lesion relating to this phenomenon which has characteristics similar to fictive scratch secondary to spinal cord transection. Medical records were searched for Cavalier King Charles spaniels with a clinical and MRI diagnosis of symptomatic SM associated with Chiari-like malformation (CM). The cohort was divided into SM with phantom scratching (19 dogs) and SM but no phantom scratching (18 dogs)...
November 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29145758/higher-level-of-chicken-consumption-associated-with-less-severe-venous-disease
#8
Kanokwan Kulprachakarn, Prakaydao Abkom, Orapin Pongtam, Sakaewan Ounjaijean, Paweena Thongkham, Suwinai Saengyo, Kittipan Rerkasem
The aim of this study was to investigate the impact of various food intake in patients with varicose veins. A cross-sectional study was conducted between December 2012 through November 2014. Patients at the outpatient department 101 at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand, who were older than > 18 years were invited to participate in this study. The severity of varicose veins was divided into 2 groups according to CEAP (clinical, etiological, anatomical, and pathophysiological) classification: mild type of venous disease (C0-C2) and severe type of venous disease (C3-C6)...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29145567/influence-of-airflow-rate-and-stimulus-concentration-on-olfactory-event-related-potentials-oerp-in-humans
#9
Pengfei Han, Valentin A Schriever, Per Peters, Heidi Olze, Florian C Uecker, Thomas Hummel
Although the association between odor concentration and olfactory event-related potential (OERP) has been studied, less is known about the influence of airflow on OERP. The aim of this study was to investigate the influence of airflow rate and stimulus concentration on OERP in humans. EEG data were collected from young healthy volunteers (n=17) in separate sessions where 2-phenylethanol (PEA) was delivered in the following conditions: 8L/min 50%v/v, 8L/min 30%v/v, 4L/min 100%v/v and 4L/min 60%v/v. Odor concentrations are referred to the %v/v achieved with air dilution and was not measured in the nose...
November 14, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29145512/impact-of-the-surgical-strategy-on-the-incidence-of-c5-nerve-root-palsy-in-decompressive-cervical-surgery
#10
Theresa Krätzig, Malte Mohme, Klaus C Mende, Sven O Eicker, Frank W Floeth
OBJECTIVE: Our aim was to identify the impact of different surgical strategies on the incidence of C5 palsy. BACKGROUND: Degenerative cervical spinal stenosis is a steadily increasing morbidity in the ageing population. Postoperative C5 nerve root palsy is a common complication with severe impact on the patients´ quality of life. METHODS: We identified 1708 consecutive patients who underwent cervical decompression surgery due to degenerative changes...
2017: PloS One
https://www.readbyqxmd.com/read/29145097/lc-esi-ms-ms-determination-of-defactinib-a-novel-fak-inhibitor-in-mice-plasma-and-its-application-to-a-pharmacokinetic-study-in-mice
#11
Gurulingappa Hallur, Natarajan Tamizharasan, Suresh P Sulochana, Neeraj Kumar Saini, Mohd Zainuddin, Ramesh Mullangi
A sensitive, specific, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of defactinib in mice plasma using (13)C3,(15)N-tofacitinib as an internal standard (I.S.). Sample preparation was accomplished through a liquid-liquid extraction process. Baseline chromatographic resolution of defactinib and the I.S. was achieved on an Atlantis dC18 column using an isocratic mobile phase comprising 0.2% formic acid in water and acetonitrile (25:75, v/v) delivered at a flow rate of 0...
November 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29144725/inhibition-of-acinetobacter-derived-cephalosporinase-adc-exploring-the-carboxylate-recognition-site-using-novel-%C3%AE-lactamase-inhibitors
#12
Emilia Caselli, Chiara Romagnoli, Rachel A Powers, Magdalena A Taracila, Alexandra A Bouza, Hollister C Swanson, Kali A Smolen, Francesco Fini, Bradley J Wallar, Robert A Bonomo, Fabio Prati
Boronic acids are attracting a lot of attention as -lactamase inhibitors, and in particular compound S02030 (Ki = 44 nM) proved to be a good lead compound against ADC-7 (Acinetobacter Derived Cephalosporinase), one of the most significant resistance determinants in A. baumannii. The atomic structure of the ADC-7/S02030 complex highlighted the importance of critical structural determinants for recognition of the boronic acids. Herein, to elucidate the role in recognition of the R2-carboxylate, which mimics the C3/C4 found in -lactams, we designed, synthesized, and characterized six derivatives of S02030 (3a)...
November 16, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29143846/organocatalytic-umpolung-annulative-dimerization-of-ynones-for-the-synthesis-of-5-alkylidene-2-cyclopentenones
#13
Dhevalapally B Ramachary, T Prabhakar Reddy, A Suresh Kumar
A novel phosphine-catalyzed umpolung [3 + 2]-annulative dimerization of ynones was developed to furnish functionally rich 5-alkylidene-2-cyclopentenones. In this protocol, ynone acts as both C2 and C3 synthons, which undergo [3 + 2]-annulative dimerization.
November 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29143318/calcineurin-inhibitor-induced-complement-system-activation-via-erk1-2-signalling-is-inhibited-by-socs-3-in-human-renal-tubule-cells
#14
Beatrix Loeschenberger, Lea Niess, Reinhard Würzner, Hubert Schwelberger, Iris E Eder, Martin Puhr, Julia Guenther, Jakob Troppmair, Michael Rudnicki, Hannes Neuwirt
One factor that significantly contributes to renal allograft loss is chronic calcineurin inhibitor (CNI) nephrotoxicity (CIN). Among other factors, the complement (C-) system has been proposed to be involved CIN development. Hence, we investigated the impact of CNIs on intracellular signalling and the effects on the C-system in human renal tubule cells. In a qPCR array, CNI treatment upregulated C-factors and downregulated SOCS-3 and the complement inhibitors CD46 and CD55. Additionally, ERK1/-2 was required for these regulations...
November 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29143032/reaction-monitoring-reveals-poisoning-mechanism-of-pd2-dba-3-and-guides-catalyst-selection
#15
Chiara Colletto, Jordi Burés, Igor Larrosa
We have discovered that the dba ligand in the commonly used Pd2(dba)3·CHCl3 cross-coupling pre-catalyst is susceptible to bis-arylation when used in the presence of aryl iodides. The in situ formed dbaAr2 ligands result in Pd-species with altered catalytic activity. In the case of study, the room temperature C3 arylation of benzo[b]thiophenes with aryl iodides, we have observed a marked catalyst deactivation when dba is arylated with electron-deficient aryl iodides, accounting for the poor yields obtained in the C3 arylation reactions with these aryl iodides...
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29142619/the-formation-of-extragraft-bone-bridging-after-anterior-cervical-discectomy-and-fusion-a-finite-element-analysis
#16
Shin Won Kwon, Chi Heon Kim, Chun Kee Chung, Tae Hyun Park, Su Heon Woo, Sung-Jae Lee, Seung Heon Yang
Objective: In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29141199/disruption-of-mitochondrial-function-as-mechanism-for-anti-cancer-activity-of-a-novel-mitochondriotropic-menadione-derivative
#17
José Teixeira, Ricardo Amorim, Katia Santos, Pedro Soares, Sandipan Datta, Gino A Cortopassi, Teresa L Serafim, Vilma A Sardão, Jorge Garrido, Fernanda Borges, Paulo J Oliveira
Menadione, also known as vitamin K3, is a 2-methyl-1,4 naphthoquinone with a potent cytotoxic activity mainly resulting from its quinone redox-cycling with production of reactive oxygen species (ROS). Although increased ROS generation is considered a relevant mechanism in cancer cell death, it may not be sufficiently effective to kill cancer cells due to phenotypic adaptations. Therefore, combining ROS-generating agents with other molecules targeting important cancer cell phenotypes can be an effective therapeutic strategy...
November 12, 2017: Toxicology
https://www.readbyqxmd.com/read/29140446/up-regulation-of-mpk4-increases-the-feeding-efficiency-of-the-green-peach-aphid-under-elevated-co2-in-nicotiana-attenuata
#18
Huijuan Guo, Xinhong Peng, Liyuan Gu, Jianqiang Wu, Feng Ge, Yucheng Sun
Previous research has shown that elevated CO2 reduces plant resistance against insects and enhances the water use efficiency of C3 plants, which improves the feeding efficiency of aphids. Although plant mitogen-activated protein kinases (MAPKs) are known to regulate water relations and phytohormone-mediated resistance, little is known about the effect of elevated CO2 on MAPKs and the cascading effects on aphids. By using stably transformed Nicotiana attenuata plants silenced in MPK4, wound-induced protein kinase (WIPK), or salicylic acid-induced protein kinase (SIPK), we determined the functions of MAPKs in plant-aphid interactions and their responses to elevated CO2...
November 11, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29138773/cooperating-dipole-dipole-and-van-der-waals-interactions-driven-2d-self-assembly-of-fluorenone-derivatives-ester-chain-length-effect
#19
Meiqiu Dong, Kai Miao, Yi Hu, Juntian Wu, Jinxing Li, Peng Pang, Xinrui Miao, Wenli Deng
Two-dimensional supramolecular assemblies of a series of 2,7-bis(10-n-alkoxycarbonyl-decyloxy)-9-fluorenone derivatives (BAF-Cn, n = 1, 3-6) consisting of polar fluorenone moieties and ester alkoxy chains were investigated by scanning tunneling microscopy on highly oriented pyrolytic graphite surfaces. The chain-length effect was observed in the self-assembly of BAF-Cn. Self-assembly of BAF-C1 was composed of a linear I pattern, where the side chains adopted a fully interdigitated arrangement. As the length of side chains increased, the coexistence of a linear I pattern and a cyclic pattern for the self-assembly of BAF-C3 was observed...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29137767/sonochemistry-of-aqueous-naaucl4-solutions-with-c3-c6-alcohols-under-a-noble-gas-atmosphere
#20
Kenji Okitsu, Itsuya Kurisaka, Ben Nanzai, Norimichi Takenaka, Hiroshi Bandow
The effect of the type of C3-C6 alcohol, solution temperature, and dissolved gas on the rate of Au(III) reduction was investigated in NaAuCl4 aqueous alcohol solution with a 200-kHz ultrasound irradiation system. It was confirmed in the presence of C3-C6 alcohol that more highly hydrophobic alcohols more effectively accumulated at the argon bubble interface region, and the reducing radicals formed here. To avoid changes in the bubble temperature during collapsing bubble, the effects of the solution temperature on the rate of Au(III) reduction and on the rate of formation of the gaseous compounds (CO, CO2, CH4, C2H2, C2H4, C2H6) were investigated in the presence of low concentration (1...
March 2018: Ultrasonics Sonochemistry
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