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https://www.readbyqxmd.com/read/28202614/virus-specific-cd8-t-cells-infiltrate-melanoma-lesions-and-retain-function-independently-of-pd-1-expression
#1
Dan A Erkes, Corinne J Smith, Nicole A Wilski, Sofia Caldeira-Dantas, Toktam Mohgbeli, Christopher M Snyder
It is well known that CD8(+) tumor-infiltrating lymphocytes (TILs) are correlated with positive prognoses in cancer patients and are used to determine the efficacy of immune therapies. Although it is generally assumed that CD8(+) TILs will be tumor-associated Ag (TAA) specific, it is unknown whether CD8(+) T cells with specificity for common pathogens also infiltrate tumors. If so, the presence of these T cells could alter the interpretation of prognostic and diagnostic TIL assays. We compared TAA-specific and virus-specific CD8(+) T cells in the same tumors using murine CMV, a herpesvirus that causes a persistent/latent infection, and vaccinia virus, a poxvirus that is cleared by the host...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28198914/action-of-vitamin-e-on-experimental-severe-acute-liver-failure
#2
Fabiano Moraes Miguel, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Renata Minuzzo Hartmann, Maria Isabel Morgan-Martins, Norma Possa Marroni
BACKGROUND: Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in increase of reactive oxygen species. The vitamin E isoform is the one with the strongest biological antioxidant activity. OBJECTIVE: To evaluate the antioxidant effect of vitamin E in this ALF model...
February 13, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28196036/a-prospective-study-of-four-total-ankle-arthroplasty-implants-by-non-designer-investigators
#3
Tina Lefrancois, Alastair Younger, Kevin Wing, Murray J Penner, Peter Dryden, Hubert Wong, Timothy Daniels, Mark Glazebrook
BACKGROUND: There are several types of prostheses available to surgeons when performing a total ankle arthroplasty (TAA). The main objective of this study was to summarize the clinical and functional outcomes of 4 TAA prostheses: the Hintegra implant (Integra LifeSciences), the Agility implant (DePuy), the Mobility implant (DePuy), and the Scandinavian Total Ankle Replacement (STAR) implant (Small Bone Innovations [SBi]). METHODS: Patients were prospectively recruited...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28193015/derivatization-strategies-for-the-detection-of-triamcinolone-acetonide-in-cartilage-by-using-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging
#4
Florian P Y Barré, Bryn Flinders, João P Garcia, Imke Jansen, Lennart R S Huizing, Tiffany Porta, Laura B Creemers, Ron M A Heeren, Berta Cillero-Pastor
Osteoarthritis (OA), characterized by degeneration of the cartilaginous tissue in articular joints, severely impairs mobility in many people worldwide. The degeneration is thought to be mediated by inflammatory processes occurring in the tissue of the joint, including the cartilage. Intra-articular administered triamcinolone acetonide (TAA) is one of the drug treatments employed to ameliorate the inflammation and pain that characterizes OA. However, the penetration and distribution of TAA into the avascular cartilage is not well understood...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28186997/autoantibodies-against-glucose-regulated-protein-78-as-serological-biomarkers-in-metastatic-and-recurrent-hepatocellular-carcinoma
#5
Xia Ying, Su-Xia Han, Chen-Chen He, Cong-Ya Zhou, Yi-Ping Dong, Meng-Jiao Cai, Xin Sui, Cheng-Xian Ma, Xiao Sun, Yuan-Yuan Zhang, Wen-Li Gou, Clifford Mason, Qing Zhu
PURPOSE: To identify Heptocellular carcinoma (HCC) associated antigens by proteomics, and validate whether autoantibodies against tumor-associated antigens (TAAs) could be used for diagnosis and conditional monitoring. RESULTS: The 78 kDa glucose regulated protein (GRP78) was selected as a candidate TAA. The titers of autoantibodies against 78 kDa glucose regulated protein (GRP78) from patients with HCC, liver cirrhosis (LC), and chronic hepatitis (CH) were significantly higher than that from normal controls (P<0...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28183817/comparison-between-the-phase-angle-and-phase-shift-parameters-to-assess-thoracoabdominal-asynchrony-in-copd-patients
#6
Desiderio Cano Porras, Adriana C Lunardi, Cibele C B Marques da Silva, Denise M Paisani, Rafael Stelmach, Henrique Takachi Moriya, Celso R F Carvalho
BACKGROUND: Determining the presence of thoracoabdominal asynchrony in chronic obstructive pulmonary disease patients is clinically relevant, but there is no consensus on the optimal parameters for performing this analysis. METHODS: We assessed 22 COPD patients (FEV1 40±10% predicted) and 13 healthy controls during rest and exercise with optoelectronic plethysmography (70% maximum workload) on a cycle ergometer. Thoracoabdominal asynchrony was calculated by using phase angle and phase shift parameters following a three-compartment model involving the upper and lower ribcages and abdomen...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28181416/preventive-effects-of-ophiocordyceps-sinensis-mycelium-on-the-liver-fibrosis-induced-by-thioacetamide
#7
Yi-Hsieng Samuel Wu, Jung-Kai Tseng, Chung-Hsi Chou, Chih-Hsien Chiu, Yi-Ling Lin, Yi-Chen Chen
Thioacetamide (TAA), usually used as a fungicide to control the decay of citrus products, itself is not toxic to the liver, but its intermediates are able to increase oxidative stress in livers and further cause fibrosis. Ophiocordyceps sinensis mycelium (OSM) which contains 10% polysaccharides and 0.25% adenosine decreased (P < 0.05) the lipid accumulation and increased (P < 0.05) antioxidative capacity in livers of thioacetamide (TAA) injected rats. Meanwhile, the increased (P < 0.05) liver sizes, serum alanine transaminase (AST) and aspartate transaminase (ALT) values in thioacetamide (TAA)-injected rats were ameliorated (P < 0...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28177688/hepato-and-neuro-protective-influences-of-biopropolis-on-thioacetamide-induced-acute-hepatic-encephalopathy-in-rats
#8
Rasha E Mostafa, Abeer A A Salama, Rehab Fawzy Abdel-Rahman, Hanan A Ogaly
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome ultimately occurs as a complication of acute or chronic liver failure; accompanied by hyperammonemia. This study aimed to evaluate the potential of biopropolis as a hepato and neuroprotective agent using thioacetamide (TAA)-induced acute HE in rats as a model. Sixty Wistar rats were divided into five groups: Group 1 (normal control) received only saline and paraffin oil. Group 2 (hepatotoxic control) received TAA (300 mg/kg, once). Groups 3, 4 and 5 received TAA followed by vitamin E (100 mg/kg) and biopropolis (100 and 200 mg/kg), respectively, daily for 30 days...
December 9, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28177321/the-crystal-structure-of-pd1-a-haemophilus-surface-fibril-domain
#9
Jack Wright, Maren Thomsen, Robert Kolodziejczyk, Joshua Ridley, Jessica Sinclair, Glenn Carrington, Birendra Singh, Kristian Riesbeck, Adrian Goldman
The Haemophilus surface fibril (Hsf) is an unusually large trimeric autotransporter adhesin (TAA) expressed by the most virulent strains of H. influenzae. Hsf is known to mediate adhesion between pathogen and host, allowing the establishment of potentially deadly diseases such as epiglottitis, meningitis and pneumonia. While recent research has suggested that this TAA might adopt a novel `hairpin-like' architecture, the characterization of Hsf has been limited to in silico modelling and electron micrographs, with no high-resolution structural data available...
February 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28174428/solvothermal-synthesis-of-cdin2s4-photocatalyst-for-selective-photosynthesis-of-organic-aromatic-compounds-under-visible-light
#10
Cancan Ling, Xiangju Ye, Jinghu Zhang, Jinfeng Zhang, Sujuan Zhang, Sugang Meng, Xianliang Fu, Shifu Chen
Ternary chalcogenide semiconductor, cadmium indium sulfide (CdIn2S4), was prepared by a simple solvothermal method using ethylene glycol as a solvent, as well as indium chloride tetrahydrate (InCl3(.)4H2O), cadmium nitrate tetrahydrate [Cd(NO3)2(.)4H2O], and thiacetamide (TAA) as precursors. The resulted sample was subject to a series of characterizations. It is the first time to use CdIn2S4 sample as a visible light-driven photocatalyst for simultaneous selective redox transformation of organic aromatic compounds...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28159818/thoracic-aortic-aneurysm-growth-role-of-sex-and-aneurysm-etiology
#11
Katie Cheung, Munir Boodhwani, Kwan-Leung Chan, Luc Beauchesne, Alexander Dick, Thais Coutinho
BACKGROUND: Thoracic aortic aneurysm (TAA) outcomes are worse in women than men, although reasons for sex differences are unknown. Because faster TAA growth is a risk factor for acute aortic syndromes, we sought to determine the role of sex and aneurysm etiology on TAA growth. METHODS AND RESULTS: Eighty-two consecutive unoperated subjects with TAA who had serial aneurysm measurements were recruited. In multivariable linear regression the association of female sex with aneurysm growth rate was assessed after adjustment for potential confounders...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28158318/the-first-complete-chloroplast-genome-sequences-of-ulmus-species-by-de-novo-sequencing-genome-comparative-and-taxonomic-position-analysis
#12
Li-Hui Zuo, Ai-Qin Shang, Shuang Zhang, Xiao-Yue Yu, Ya-Chao Ren, Min-Sheng Yang, Jin-Mao Wang
Elm (Ulmus) has a long history of use as a high-quality heavy hardwood famous for its resistance to drought, cold, and salt. It grows in temperate, warm temperate, and subtropical regions. This is the first report of Ulmaceae chloroplast genomes by de novo sequencing. The Ulmus chloroplast genomes exhibited a typical quadripartite structure with two single-copy regions (long single copy [LSC] and short single copy [SSC] sections) separated by a pair of inverted repeats (IRs). The lengths of the chloroplast genomes from five Ulmus ranged from 158,953 to 159,453 bp, with the largest observed in Ulmus davidiana and the smallest in Ulmus laciniata...
2017: PloS One
https://www.readbyqxmd.com/read/28148666/custom-made-total-ankle-arthroplasty-for-the-salvage-of-major-talar-bone-loss
#13
J Wagener, C E Gross, C Schweizer, T Horn Lang, B Hintermann
AIMS: A failed total ankle arthroplasty (TAA) is often associated with much bone loss. As an alternative to arthrodesis, the surgeon may consider a custom-made talar component to compensate for the bone loss. Our aim in this study was to assess the functional and radiological outcome after the use of such a component at mid- to long-term follow-up. PATIENTS AND METHODS: A total of 12 patients (five women and seven men, mean age 53 years; 36 to77) with a failed TAA and a large talar defect underwent a revision procedure using a custom-made talar component...
February 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28148263/potency-and-selectivity-indices-of-acetone-leaf-extracts-of-nine-selected-south-african-trees-against-six-opportunistic-enterobacteriaceae-isolates-from-commercial-chicken-eggs
#14
Ishaku L Elisha, Alexander R Jambalang, Francien S Botha, Elna M Buys, Lyndy J McGaw, Jacobus N Eloff
BACKGROUND: The rise in antimicrobial resistance in a plethora of nosocomial and opportunistic bacterial pathogens often isolated from commercial eggs, poses a serious public health concern. The existence of these contaminants may also serve as a drawback in the current efforts of improving the well-being of immunocompromised patients. The aim of this study was to determine the efficacy of plant extracts that had good activity on Escherichia coli in previous word on pathogens isolated from eggs for possible use in combating pathogens from eggs...
February 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28138057/biochemical-and-chemical-biology-study-of-rice-ostar1-revealed-that-tryptophan-aminotransferase-is-involved-in-auxin-biosynthesis-identification-of-a-potent-ostar1-inhibitor-pyruvamine2031
#15
Yusuke Kakei, Ayako Nakamura, Mitsuhiro Yamamoto, Yosuke Ishida, Chiaki Yamazaki, Akiko Sato, Megumi Narukawa-Nara, Kazuo Soeno, Yukihisa Shimada
Indole-3-acetic acid (IAA), a major form of auxin, is biosynthesized from L-tryptophan via the indole-3-pyruvic acid (IPyA) pathway in Arabidopsis Tryptophan aminotransferases (TAA1/TARs) catalyze the first step from L-tryptophan to IPyA. In rice, the importance of TAA/TARs or YUC homologs in auxin biosynthesis has been suggested, but the enzymatic activities and involvement of the intermediate IPyA in auxin biosynthesis remain elusive. In this study, we obtained biochemical evidence that the rice tryptophan aminotransferase OsTAR1 converts L-tryptophan to IPyA, and has a Km of 82...
January 30, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28129580/immunotherapy-with-dendritic-cells-modified-with-tumor-associated-antigen-gene-demonstrates-enhanced-antitumor-effect-against-lung-cancer
#16
Tao Jiang, Xiao Chen, Wei Zhou, Guoxin Fan, Peilin Zhao, Shengxiang Ren, Caicun Zhou, Jun Zhang
BACKGROUND: Immunotherapy using dendritic cell (DC) vaccine has the potential to overcome the bottleneck of cancer therapy. METHODS: We engineered Lewis lung cancer cells (LLCs) and bone marrow-derived DCs to express tumor-associated antigen (TAA) ovalbumin (OVA) via lentiviral vector plasmid encoding OVA gene. We then tested the antitumor effect of modified DCs both in vitro and in vivo. RESULTS: The results demonstrated that in vitro modified DCs could dramatically enhance T-cell proliferation (P<...
January 24, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28129121/masked-chimeric-antigen-receptor-for-tumor-specific-activation
#17
Xiaolu Han, Paul D Bryson, Yifan Zhao, Gunce E Cinay, Si Li, Yunfei Guo, Natnaree Siriwon, Pin Wang
Adoptive cellular therapy based on chimeric antigen receptor (CAR)-engineered T (CAR-T) cells is a powerful form of cancer immunotherapy. CAR-T cells can be redirected to specifically recognize tumor-associated antigens (TAAs) and induce high levels of antitumor activity. However, they may also display "on-target off-tumor" toxicities, resulting from low-level expression of TAAs in healthy tissues. These adverse effects have raised considerable safety concerns and limited the clinical application of this otherwise promising therapeutic modality...
January 4, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28127985/the-detection-of-curcumins-antitumoral-effects-via-argyrophilic-nucleolar-organizing-region-associated-protein-synthesis-in-mice-with-ehrlich-s-ascitic-carcinoma
#18
M Nisari, S Yilmaz, R Eroz, T Ertekin, D Bircan, H Ulger
BACKGROUND: Curcumin is a polyphenol compound that has antioxidant, anticancer, anti-inflammatory, anti-hyperlipidemic and antimicrobial effects. Nucleolar-organizing regions are the sites of the gene on chromosomes. The present study was aimed to show the antitumoral effect of curcumin via AgNOR protein synthesis in Ehrlich's ascitic carcinoma (EAC) bearing mice. METHODS: Twenty three mice with EAC were randomly divided into 3 groups as positive control (n = 7), group 2 (n = 8) and 3 (n = 8) treated intraperitoneally with curcumin (25 mg/kg) and (50 mg/kg), respectively...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28111769/suitability-of-combination-of-calcium-propionate-and-chitosan-for-preserving-minimally-processed-banana-quality
#19
Amin Mirshekari, Babak Madani, John B Golding
BACKGROUND: Marketability of fresh-cut banana slices is limited by the rapid rate of fruit softening and browning. However there is no scientific literature on the role of postharvest calcium propionate and chitosan treatment on quality attributes of fresh cut banana and therefore the aim of this research was to investigate these effects. RESULTS: This study showed that the application of calcium propionate plus chitosan (CaP+Chit) treatment retained higher firmness, ascorbic acid content (AA) content, total antioxidant activity (TAA) and total phenolic compounds (TPC) with lower browning, polyphenol oxidase (PPO), peroxidase (POD), polygalacturonase (PG) and pectin methyl esterase (PME) activities and microbial growth compared with the control banana slices after five days of cold storage...
January 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28107662/a-simple-and-powerful-co-delivery-system-based-on-ph-responsive-metal-organic-frameworks-for-enhanced-cancer-immunotherapy
#20
Fei Duan, Xiaochen Feng, Xinjian Yang, Wentong Sun, Yi Jin, Huifang Liu, Kun Ge, Zhenhua Li, Jinchao Zhang
Tumor-associated antigens (TAAs)-loaded nanoparticles are able to be actively internalized by antigen-presenting cells (APCs) and have shown promising potential in cancer immunotherapy. However, current TAAs delivery strategy exhibits limitations of complicated synthesis process, low loading efficiency and inefficient CD8(+) cytotoxic T lymphocyte activation leading to unsatisfactory therapeutic effect. Thus, the construction of novel TAAs-delivery systems for enhanced cancer therapy is highly desirable. In this work, we fabricated a very simple yet powerful antigens-delivery system for cancer immunotherapy based-on pH-responsive metal-organic frameworks (MOFs) with size about 30 nm...
January 11, 2017: Biomaterials
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