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https://www.readbyqxmd.com/read/28426222/structural-and-dynamical-properties-of-tetra-alkyl-ammonium-bromide-aqueous-solutions-a-molecular-dynamics-simulation-study-using-a-polarizable-force-field
#1
Dengpan Dong, Justin B Hooper, Dmitry Bedrov
Understanding the behavior of aqueous solutions containing tetra-alkyl ammonium (TAA) cations is of great significance in a number of applications, including polymer membranes for fuel cells. In this work, a polarizable force field has been used to preform atomistic molecular dynamics (MD) simulations of aqueous solutions containing tetra-methyl ammonium (TMA) or tetra-butyl ammonium (TBA) cations and Br counterions. Extensive MD simulations of TMA-Br/water and TBA-Br/water systems were conducted as a function of solution composition (ion pair : water molar ratios of 1:10, 1:20, 1:30, 1:63, 1:500) at atmospheric pressure and 298K...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28425970/aneurysm-specific-mir-221-and-mir-146a-participates-in-human-thoracic-and-abdominal-aortic-aneurysms
#2
Premakumari Venkatesh, Julie Phillippi, Sasanka Chukkapalli, Mercedes Rivera-Kweh, Irina Velsko, Thomas Gleason, Paul VanRyzin, Seyed Hossein Aalaei-Andabili, Ravi Kiran Ghanta, Thomas Beaver, Edward Kar Leung Chan, Lakshmyya Kesavalu
Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA and AAA operative specimens compared to controls. We observed significant upregulation of miR-221 and downregulation of miR-1 and -133 in TAA specimens. In contrast, upregulation of miR-146a and downregulation of miR-145 and -331-3p were found only for AAA specimens...
April 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416039/pig-cognitive-bias-affects-the-conversion-of-muscle-into-meat-by-antioxidant-and-autophagy-mechanisms
#3
Y Potes, M Oliván, A Rubio-González, B de Luxán-Delgado, F Díaz, V Sierra, L Arroyo, R Peña, A Bassols, J González, R Carreras, A Velarde, M Muñoz-Torres, A Coto-Montes
Slaughter is a crucial step in the meat production chain that could induce psychological stress on each animal, resulting in a physiological response that can differ among individuals. The aim of this study was to investigate the relationship between an animal's emotional state, the subsequent psychological stress at slaughter and the cellular damage as an effect. In all, 36 entire male pigs were reared at an experimental farm and a cognitive bias test was used to classify them into positive bias (PB) or negative bias (NB) groups depending on their decision-making capabilities...
April 18, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28414437/phenolic-content-and-antioxidant-activity-during-the-development-of-brookfield%C3%A2-and-mishima-apples
#4
Mayara C Stanger, Cristiano A Steffens, Cristina Soethe, Marcelo A Moreira, Cassandro V T do Amarante
The aim of this study was to characterize the changes in the contents of total (TPC) and individual (IPC) phenolic compounds and the total antioxidant activity (TAA) in the peel and pulp, and total anthocyanins (TAN) in the peel, during the development of the fruits of Brookfield® and Mishima apple trees. 'Brookfield®' apples were harvested from the 49th to 138th days after full bloom (DAFB) and 'Mishima' apples from the 45th to 172th DAFB. In the pulp, the IPC, TPC and TAA rapidly reduced at 75 and 79 DAFB for the 'Brookfield®' and 'Mishima' apples, respectively, and then remained constant until commercial maturity...
April 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28413030/the-role-matrix-metalloproteinases-in-the-production-of-aortic-aneurysm
#5
Simon W Rabkin
Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and the destruction of extracellular matrix (ECM). Furthermore, AAA have evidence of inflammation and the cellular elements involved in inflammation such as macrophages can produce and/or activate MMPs This chapter focuses on human aortic aneurysm that are not due to specific known genetic causes because this type of aneurysm is the more common type...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28411526/endovascular-repair-of-a-ruptured-thoracic-aortic-dissection-with-a-right-sided-aortic-arch-a-case-report
#6
Jeremy L Irvan, James R Elmore, Sarah L Flora, Evan J Ryer
BACKGROUND: Emergency treatment of complex aortic pathology is challenging in the setting of a right-sided aortic arch. We report the successful treatment of a ruptured thoracic aortic aneurysm (TAA) in the setting of a Stanford type B aortic dissection (TBAD) and right-sided aortic arch. PRESENTATION OF CASE: The patient is a 66-year-old male with chronic kidney disease (CKD) admitted with right sided chest pain and hypotension. Computed tomography angiography (CTA) revealed a 5cm ruptured TAA in the setting of a TBAD and right-sided aortic arch...
March 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28395572/protective-effects-of-ampelopsis-brevipedunculata-against-in-vitro-hepatic-stellate-cells-system-and-thioacetamide-induced-liver-fibrosis-rat-model
#7
Mun Jeong Yum, Sushruta Koppula, Jin Seoub Kim, Gwang Mo Shin, Yun Jin Chae, Tony Yoon, Chi Su Chun, Jae Dong Lee, MinDong Song
CONTEXT: Ampelopsis brevipedunculata Maxim (Vitaceae) is a traditional medicinal herb used for treating liver disorders. OBJECTIVE: The hepatoprotective effects of A. brevipedunculata ethanol extract (ABE) was investigated in experimental models of fibrosis. MATERIALS AND METHODS: Hepatic stellate cells (HSCs) system in vitro and thioacetamide (TAA)-induced liver fibrosis rat model in vivo were used. Sprague-Dawley rats were divided into five groups of eight each (control, TAA, TAA with ABE 10 mg/kg, ABE 100 mg/kg and silymarin 50 mg/kg groups, respectively)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28387399/self-template-synthesis-of-hollow-ellipsoid-ni-mn-sulfides-for-supercapacitors-electrocatalytic-oxidation-of-glucose-and-water-treatment
#8
Cheng Cheng, Dechen Kong, Chengzhen Wei, Weimin Du, Jianbo Zhao, Yeqin Feng, Qingling Duan
In this work, we have successfully developed a simple self-template route for preparation of hollow ellipsoid Ni-Mn sulfides. This route involves the synthesis of solid Ni-Mn ellipsoids via a chemical precipitation method. Then, using thioacetamide (TAA) as the sulfur source, the solid Ni-Mn ellipsoids can be easily converted to hollow ellipsoid Ni-Mn sulfides in ethanol via sulfidation reaction. The as-synthesized hollow ellipsoid Ni-Mn sulfides possess large specific surface areas and porous structures. Benefiting from these structural and compositional advantages, the electrochemical performance of the hollow ellipsoid Ni-Mn sulfides is studied...
April 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28386812/a-novel-technique-of-total-debranching-tevar-with-inflow-from-the-descending-aorta
#9
Saiki Munehiro, Yunoki Keiji, Sakoda Naoya, Hattori Shigeru, Uchino Gaku, Kawabata Takuya, Fujita Yasufumi, Hisamochi Kunikazu, Yoshida Hideo
An 82-year-old male with TAA was considered high risk for conventional surgery because of previous CABG. Therefore, a hybrid repair was performed. First, the arch vessels were debranched extra-anatomical bypass. Second, left thoracotomy was performed. The proximal side of a bifurcated graft was anastomosed to the descending aorta. To arch vessels' debranch graft, two bifurcated graft distal limbs were anastomosed with a 10-mm distance. Two stentgrafts were deployed from the ascending to descending aorta. Postoperative CT did not reveal any endoleak, and all debranch grafts were patent...
April 6, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28384231/the-mitochondrial-genome-of-pin-tailed-snipe-gallinago-stenura-and-its-implications-for-the-phylogeny-of-charadriiformes
#10
Chaochao Hu, Chenling Zhang, Lei Sun, Yi Zhang, Wenli Xie, Baowei Zhang, Qing Chang
The Charadriiformes, among the most diverse orders of bird, is a good source to research on evolution. The mitochondrial genome sequencing database has rapidly increased in recent years, while Charadriiformes mitogenome has not been well studied. In this research, we determined the complete mitogenome sequence of Gallinago stenura, and comparatively analysed 20 mitogenomes of Charadriiformes. The mitogenomes display moderate size variation, and most of variation due to mutations in the control region. In 13 protein-coding genes, we found: 1...
2017: PloS One
https://www.readbyqxmd.com/read/28383249/ion-separation-in-air-using-a-three-dimensional-printed-ion-mobility-spectrometer
#11
Adam Hollerbach, Zane Baird, R Graham Cooks
The performance of a small, plastic drift tube ion mobility spectrometer (DT-IMS) is described. The IMS was manufactured using three-dimensional (3D) printing techniques and operates in the open air at ambient pressure, temperature, and humidity. The IMS housing and electrodes were printed from nonconductive polylactic acid (PLA, housing) and conductive polyethylene terephthalate glycol-modified polymer containing multiwalled carbon nanotubes (PETG-CNT, electrodes). Ring electrodes consisting of both an inner disk and an outer ring were used to prevent neutral transmission while maximizing ion transmission...
April 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28374412/effects-of-microporous-stent-graft-on-the-descending-aortic-aneurysm-a-patient-specific-computational-fluid-dynamics-study
#12
Chi-Wei Ong, Pei Ho, Hwa-Liang Leo
Thoracic endovascular aortic repair (TEVAR) method is an alternative treatment for thoracic aortic aneurysm (TAA) compared to open surgery. It is believed that stent graft implantation can potentially reduce the risk of aneurysm rupture by altering the associated blood flow disturbances within an aneurysm. To investigate the hemodynamics changes of TEVAR intervention to the TAA, three models, namely healthy, aneurysm before treatment, and aneurysm after stent graft implantation models were built. These three models were presented and compared in terms of their flow patterns, time-averaged wall shear stress (TAWSS), oscillating shear index (OSI), and relative residence time (RRT)...
November 2016: Artificial Organs
https://www.readbyqxmd.com/read/28372490/microrna-signatures-associated-with-thioacetamide-induced-liver-fibrosis-in-mice
#13
Jae-Sang Hong, Do-Hoon Lee, Ye Won Yook, Dokyun Na, Yu Jin Jang, Jong-Hoon Kim, Young Sik Lee
Multiple etiologies of liver injury are associated with fibrosis in which the key event is the activation of hepatic stellate cells (HSCs). Although microRNAs (miRNAs) are reportedly involved in fibrogenesis, the complete array of miRNA signatures associated with the disease has yet to be elucidated. Here, deep sequencing analysis revealed that compared to controls, 80 miRNAs were upregulated and 21 miRNAs were downregulated significantly in the thioacetamide (TAA)-induced mouse fibrotic liver. Interestingly, 58 of the upregulated miRNAs were localized to an oncogenic miRNA megacluster upregulated in liver cancer...
April 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28362497/intramolecular-light-driven-accumulation-of-reduction-equivalents-by-proton-coupled-electron-transfer
#14
Martin Kuss-Petermann, Margherita Orazietti, Markus Neuburger, Peter Hamm, Oliver S Wenger
The photochemistry of a molecular pentad composed of a central anthraquinone (AQ) acceptor flanked by two Ru(bpy)3(2+) photosensitizers and two peripheral triarylamine (TAA) donors was investigated by transient IR and UV-vis spectroscopies in the presence of 0.2 M p-toluenesulfonic acid (TsOH) in deaerated acetonitrile. In ∼15% of all excited pentad molecules, AQ is converted to its hydroquinone form (AQH2) via reversible intramolecular electron transfer from the two TAA units (τ = 65 ps), followed by intermolecular proton transfer from TsOH (τ ≈ 3 ns for the first step)...
March 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28358027/temperature-tunable-fano-resonance-induced-by-strong-coupling-between-weyl-fermions-and-phonons-in-taas
#15
B Xu, Y M Dai, L X Zhao, K Wang, R Yang, W Zhang, J Y Liu, H Xiao, G F Chen, S A Trugman, J-X Zhu, A J Taylor, D A Yarotski, R P Prasankumar, X G Qiu
Strong coupling between discrete phonon and continuous electron-hole pair excitations can induce a pronounced asymmetry in the phonon line shape, known as the Fano resonance. This effect has been observed in various systems. Here we reveal explicit evidence for strong coupling between an infrared-active phonon and electronic transitions near the Weyl points through the observation of a Fano resonance in the Weyl semimetal TaAs. The resulting asymmetry in the phonon line shape, conspicuous at low temperatures, diminishes continuously with increasing temperature...
March 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28356219/cell-wall-%C3%AE-1-3-glucan-prevents-%C3%AE-amylase-adsorption-onto-fungal-cell-in-submerged-culture-of-aspergillus-oryzae
#16
Silai Zhang, Hiroki Sato, Sakurako Ichinose, Mizuki Tanaka, Ken Miyazawa, Akira Yoshimi, Keietsu Abe, Takahiro Shintani, Katsuya Gomi
We have previously reported that α-amylase (Taka-amylase A, TAA) activity disappears in the later stage of submerged Aspergillus oryzae culture as a result of TAA adsorption onto the cell wall. Chitin, one of the major components of the cell wall, was identified as a potential factor that facilitates TAA adsorption. However, TAA adsorption only occurred in the later stage of cultivation, although chitin was assumed to be sufficiently abundant in the cell wall regardless of the submerged culture period. This suggested the presence a factor that inhibits TAA adsorption to the cell wall in the early stage of cultivation...
March 26, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28356156/chimeric-antigen-receptor-t-cells-a-novel-therapy-for-solid-tumors
#17
REVIEW
Shengnan Yu, Anping Li, Qian Liu, Tengfei Li, Xun Yuan, Xinwei Han, Kongming Wu
The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor cells by interacting with the tumor-associated antigens (TAAs) expressing on tumor cell surface. Current studies demonstrated that various TAAs could act as target antigens for CAR-T cells, for instance, the type III variant epidermal growth factor receptor (EGFRvIII) was considered as an ideal target for its aberrant expression on the cell surface of several tumor types...
March 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28344889/loss-of-tapasin-in-human-lung-and-colon-cancer-cells-and-escape-from-tumor-associated-antigen-specific-ctl-recognition
#18
Yosuke Shionoya, Takayuki Kanaseki, Sho Miyamoto, Serina Tokita, Ayumi Hongo, Yasuhiro Kikuchi, Vitaly Kochin, Kazue Watanabe, Ryota Horibe, Hiroshi Saijo, Tomohide Tsukahara, Yoshihiko Hirohashi, Hiroki Takahashi, Noriyuki Sato, Toshihiko Torigoe
Cytotoxic T-lymphocytes (CTLs) lyse target cells after recognizing the complexes of peptides and MHC class I molecules (pMHC I) on cell surfaces. Tapasin is an essential component of the peptide-loading complex (PLC) and its absence influences the surface repertoire of MHC class I peptides. In the present study, we assessed tapasin expression in 85 primary tumor lesions of non-small cell lung cancer (NSCLC) patients, demonstrating that tapasin expression positively correlated with patient survival. CD8(+) T-cell infiltration of tumor lesions was synergistically observed with tapasin expression and correlated positively with survival...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28344863/tumor-infiltrating-lymphocytes-tils-from-patients-with-glioma
#19
Zhenjiang Liu, Qingda Meng, Jiri Bartek, Thomas Poiret, Oscar Persson, Lalit Rane, Elena Rangelova, Christopher Illies, Inti Harvey Peredo, Xiaohua Luo, Martin Vijayakumar Rao, Rebecca Axelsson Robertson, Ernest Dodoo, Markus Maeurer
Tumor-infiltrating lymphocytes (TILs) may represent a viable source of T cells for the biological treatment of patients with gliomas. Glioma tissue was obtained from 16 patients, tumor cell lines were established, and TILs were expanded in 16/16 cases using a combination of IL-2/IL-15/IL-21. Intracellular cytokine staining (ICS, IL-2, IL-17, TNFα and IFNγ production) as well as a cytotoxicity assay was used to detect TIL reactivity against autologous tumor cells or shared tumor-associated antigens (TAAs; i...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28339253/distinct-evolutions-of-weyl-fermion-quasiparticles-and-fermi-arcs-with-bulk-band-topology-in-weyl-semimetals
#20
N Xu, G Autès, C E Matt, B Q Lv, M Y Yao, F Bisti, V N Strocov, D Gawryluk, E Pomjakushina, K Conder, N C Plumb, M Radovic, T Qian, O V Yazyev, J Mesot, H Ding, M Shi
The Weyl semimetal phase is a recently discovered topological quantum state of matter characterized by the presence of topologically protected degeneracies near the Fermi level. These degeneracies are the source of exotic phenomena, including the realization of chiral Weyl fermions as quasiparticles in the bulk and the formation of Fermi arc states on the surfaces. Here, we demonstrate that these two key signatures show distinct evolutions with the bulk band topology by performing angle-resolved photoemission spectroscopy, supported by first-principles calculations, on transition-metal monophosphides...
March 10, 2017: Physical Review Letters
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