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https://www.readbyqxmd.com/read/28087696/genetic-and-biochemical-characterization-of-a-gene-operon-for-trans-aconitic-acid-a-novel-nematicide-from-bacillus-thuringiensis
#1
Cuiying Du, Shiyun Cao, Xiangyu Shi, Xiangtao Nie, Jinshui Zheng, Yun Deng, Lifang Ruan, Donghai Peng, Ming Sun
Trans-aconitic acid (TAA) is an isomer of cis-aconitic acid (CAA), an intermediate of the tricarboxylic acid (TCA) cycle that is synthesized by aconitase. Although TAA production has been detected in bacteria and plants for many years and is known to be a potent inhibitor of aconitase, its biosynthetic origins and the physiological relevance of its activity have remained unclear. We have serendipitously uncovered key information relevant to both of these questions. Specifically, in a search for novel nematicidal factors from Bacillus thuringiensis, a significant nematode pathogen harboring many protein virulence factors, we discovered a high-yielding component that showed activity against the plant-parasitic nematode Meloidogyne incognita and surprisingly identified it as TAA...
January 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28077313/a-kind-of-rd1-mouse-in-c57bl-6j-mice-from-crossing-with-a-mutated-kunming-mouse
#2
Weiming Yan, Lu Yao, Wei Liu, Kai Sun, ZuoMing Zhang, Lei Zhang
We occasionally discovered a mouse with spontaneous retinitis pigmentosa (RP) from Kunming (KM) mouse breeding colony, with no obvious waveforms in ERG recordings. The aim of this study is to cross the spontaneously hereditary retinal degeneration mice (temporarily designated as KM/rd mice) derived from KM mice with C57BL/6J mice to establish a congenic inbred strain (temporarily designated as the B6/rd mice), and study the ocular phenotype and genotype of the mice. Fundus photography, tissue morphology, electroretinography (ERG), qRT-PCR, western blot and DNA sequence analysis were performed to observe the ocular phenotype and genotype of KM/rd and B6/rd mice...
January 8, 2017: Gene
https://www.readbyqxmd.com/read/28073888/selective-targeting-of-lysyl-oxidase-like-2-loxl2-suppresses-hepatic-fibrosis-progression-and-accelerates-its-reversal
#3
Naoki Ikenaga, Zhen-Wei Peng, Kahini A Vaid, Susan B Liu, Shuhei Yoshida, Deanna Y Sverdlov, Amanda Mikels-Vigdal, Victoria Smith, Detlef Schuppan, Yury V Popov
BACKGROUND/AIMS: We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen crosslinking and hepatic progenitor cell (HPC) differentiation, and the therapeutic efficacy of a LOXL2-blocking monoclonal antibody on liver fibrosis progression/reversal in mice. METHODS: Anti-LOXL2 antibody, control antilysyl oxidase antibody or placebo was administered during thioacetamide (TAA)-induced fibrosis progression or during recovery. Therapeutic efficacy in biliary fibrosis was tested in BALB/c...
January 10, 2017: Gut
https://www.readbyqxmd.com/read/28071685/mesoscopic-superconductivity-and-high-spin-polarization-coexisting-at-metallic-point-contacts-on-weyl-semimetal-taas
#4
Leena Aggarwal, Sirshendu Gayen, Shekhar Das, Ritesh Kumar, Vicky Süß, Claudia Felser, Chandra Shekhar, Goutam Sheet
A Weyl semimetal is a topologically non-trivial phase of matter that hosts mass-less Weyl fermions, the particles that remained elusive for more than 80 years since their theoretical discovery. The Weyl semimetals exhibit unique transport properties and remarkably high surface spin polarization. Here we show that a mesoscopic superconducting phase with critical temperature Tc=7 K can be realized by forming metallic point contacts with silver (Ag) on single crystals of TaAs, while neither Ag nor TaAs are superconductors...
January 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28064445/a-panel-of-autoantibodies-against-multiple-tumor-associated-antigens-for-detecting-gastric-cancer
#5
Isamu Hoshino, Matsuo Nagata, Nobuhiro Takiguchi, Yoshihiro Nabeya, Atsushi Ikeda, Sana Yokoi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Yajima Satoshi, Shimada Hideaki
Gastric cancer is the second leading cause of cancer deaths in the world, and effective diagnosis is extremely important for good outcome. We assessed the diagnostic potential of an autoantibody panel that may provide a novel tool for the early detection of gastric cancer. We analyzed data from patients with gastric cancer and normal controls in a test and validation cohorts. Autoantibody levels were measured against a panel of six tumor-associated antigens [TAAs; p53, heat shock protein 70 (HSP70), HCC-22-5, peroxiredoxin VI (Prx VI), KM-HN-1, and p90 TAA (CYP2A)] via ELISA...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28061741/economic-analysis-and-patient-satisfaction-associated-with-outpatient-total-ankle-arthroplasty
#6
Tyler Gonzalez, Erica Fisk, Christopher Chiodo, Jeremy Smith, Eric Bluman
BACKGROUND: Total ankle arthroplasty (TAA) is a rapidly growing treatment for end-stage ankle arthritis that is generally performed as an inpatient procedure. The feasibility of outpatient total ankle arthroplasty (OTAA) has not been reported in the literature. We sought to establish proof of concept for OTAA by comparing outpatient vs inpatient perioperative complications, postoperative emergency department (ED) visits, readmissions, patient satisfaction, and cost analysis. METHODS: From July 2010 to September 2015, a total of 36 patients underwent TAA...
December 1, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/28058114/protective-effects-of-co-enzyme-q10-on-thioacetamide-induced-acute-liver-damage-and-its-correlation-with-behavioral-biochemical-and-pathological-factors
#7
Soheil Ashkani-Esfahani, Fereshteh Bagheri, Yasaman Emami, Elmira Esmaeilzadeh, Negar Azarpira, Nazila Hassanabadi, Marzieh Keshtkar, Mojtaba Farjam, Omid Koohi-Hosseinabadi, Ali Noorafshan
BACKGROUND: Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death. OBJECTIVES: In this experimental study we determined whether coenzyme Q10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against thioacetamide (TAA)-induced liver damage and its related neurobehavioral alterations in rats...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28053566/protective-effect-of-olive-and-juniper-leaves-extracts-on-nephrotoxicity-induced-by-thioacetamide-in-male-mice
#8
Atef M Al-Attar, Ali A Alrobai, Daklallah A Almalki
This study, for the first time, evaluates the effect of olive and juniper leaves extracts and their combination on thioacetamide (TAA)-induced nephrotoxicity in male mice. The experimental mice were divided into eight groups. Group 1 was served as control. Group 2 was exposed to TAA. Group 3 was treated with TAA and olive leaves extract. Group 4 was subjected to TAA and juniper leaves extract. Group 5 was exposed to TAA and olive and juniper leaves extracts. Groups 6, 7 and 8 were treated with olive, juniper, and olive and juniper leaves extracts respectively...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28053250/the-painful-total-ankle-arthroplasty-a-diagnostic-and-treatment-algorithm
#9
REVIEW
E Vulcano, M S Myerson
The last decade has seen a considerable increase in the use of in total ankle arthroplasty (TAA) to treat patients with end-stage arthritis of the knee. However, the longevity of the implants is still far from that of total knee and hip arthroplasties. The aim of this review is to outline a diagnostic and treatment algorithm for the painful TAA to be used when considering revision surgery. Cite this article: Bone Joint J 2017;99-B:5-11.
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28053197/chimeric-antigen-receptor-t-cells-therapy-for-tumor-immunotherapy
#10
Huanhuan Sha, Dandan Wang, Dali Yan, Yong Hu, Sujin Lang, Siwen Liu, Jifeng Feng
Chimeric antigen receptor (CAR) T cells therapies, as one of the cancer immunotherapies, have heralded a new era of treating cancer. The accumulating data, especially about CAR modified T cells against CD19 support that CAR-T cells therapy is a highly effective immune therapy for B-cell malignancies. Apart from CD19, there have been many trials of CAR T cells directed other tumor specific or associated antigens (TSAs/TAAs) in hematologic malignancies and solid tumors. This review will briefly summarize basic CAR structure, parts of reported TSAs/TAAs, results of the clinical trials of CAR-T cells therapies as well as two life-threatening side effects...
January 4, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28041736/technical-note-methodological-and-feed-factors-affecting-prediction-of-ruminal-degradability-and-intestinal-digestibility-of-essential-amino-acids
#11
Robin R White, Paul J Kononoff, Jeffrey L Firkins
We hypothesized that ruminal degradability of essential AA (EAA) and the intestinal digestibility of the ruminally undegraded EAA residue in feeds could be evaluated in a meta-analysis. The objective was to characterize methodological factors for ruminal incubation (time of incubation of feed in situ) and method of simulating digestion of the ruminally undegraded AA (incubation of residue in digestive enzymes in vitro or in mobile bags inserted into the duodenum). To increase numbers of observations, feeds were categorized before ANOVA...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28040750/a-minimally-invasive-approach-for-open-surgical-thoracoabdominal-aortic-replacement-experimental-concept-for-a-novel-surgical-procedure
#12
Terézia B Andrási, Violetta Kékesi, Béla Merkely, Marius Grossmann, Bernhard C Danner, Friedrich A Schöndube
OBJECTIVES: We aimed to develop a simple, reliable, and timesaving technique for the therapy of thoracoabdominal aortic (TAA) aneurysms that are not suitable for endovascular repair. METHODS: In this pilot study, we sought to combine the advantages of classic open vascular procedure with the use of endoscopic surgical tools and small skin incisions to develop a minimally invasive approach for TAA replacement. The following procedures were used: endoscopic exposure and closure of the lower intercostal arteries; small posterolateral thoracotomy and left retroperitoneal incisions to expose the anastomotic regions of the aorta; partial anticoagulation; passive bypass and sequential aortic clamping; tunnelling of the graft through the native aortic lumen (endoaneurysmorrhaphy) and open performance of vascular anastomosis...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28039485/antagonism-of-interleukin-17a-ameliorates-experimental-hepatic-fibrosis-by-restoring-the-il-10-stat3-suppressed-autophagy-in-hepatocytes
#13
Xiao-Wei Zhang, Su Mi, Zhe Li, Ji-Chao Zhou, Jing Xie, Fang Hua, Ke Li, Bing Cui, Xiao-Xi Lv, Jiao-Jiao Yu, Zhuo-Wei Hu
Interleukin-17A has been identified as a driver of hepatic stellate cell activation and plays a critical role in the pathogenesis of hepatic fibrosis. However, the underlining fibrosis-promoting mechanism of IL-17A is far from understood. Here we aimed to define whether hepatocytes directly respond to IL-17A stimulation and are associated with the development of hepatic fibrosis. The functional significance of IL-17A was evaluated in bile duct ligation (BDL) or thioacetamide (TAA) injection-induced mouse models of hepatic fibrosis...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28018347/advances-in-therapeutic-fc-engineering-modulation-of-igg-associated-effector-functions-and-serum-half-life
#14
REVIEW
Abhishek Saxena, Donghui Wu
Today, monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers. Efficacy of monoclonal antibodies (mAbs) is achieved through both its antigen-binding fragment (Fab) and crystallizable fragment (Fc). Fab can specifically recognize tumor-associated antigen (TAA) and thus modulate TAA-linked downstream signaling pathways that may lead to the inhibition of tumor growth, induction of tumor apoptosis, and differentiation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28018219/silymarin-protects-mouse-liver-and-kidney-from-thioacetamide-induced-toxicity-by-scavenging-reactive-oxygen-species-and-activating-pi3k-akt-pathway
#15
Shatadal Ghosh, Abhijit Sarkar, Sudip Bhattacharyya, Parames C Sil
Silymarin (SMN) has been shown to possess a wide range of biological and pharmacological effects. Besides, SMN has antioxidant and free radical scavenging activities. Thioacetamide (TAA) is a well-documented liver toxin that requires oxidative bioactivation to elicit its hepatotoxic effect which ultimately modifies amine-lipids and proteins. Our study has been designed in a TAA exposed mouse model to investigate whether SMN could protect TAA-induced oxidative stress mediated hepatic and renal damage. Results suggest that TAA generated reactive oxygen species (ROS), caused oxidative stress and induced apoptosis in the liver and kidney cells via JNK as well as PKC and MAPKs signaling...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28013296/thoracoabdominal-asynchrony-is-not-associated-with-oxyhemoglobin-saturation-in-recovering-premature-infants
#16
Colleen Brennan, Lara Ulm, Samuel Julian, Aaron Hamvas, Thomas Ferkol, Julie Hoffman, Laura Linneman, James Kemp
BACKGROUND: Recovering premature infants are at risk for hypoxemia and lack of synchrony between their rib cage and abdomen due to airflow obstruction and poor respiratory compliance. Thoracoabdominal asynchrony (TAA) is a useful marker of resistive and elastic lung properties. Whether TAA predicts oxygenation is unknown. OBJECTIVES: We investigated oxyhemoglobin saturation (SpO2%) and TAA (phase angle, φ) in preterm infants with/without high-humidity nasal cannula (HHNC)...
December 24, 2016: Neonatology
https://www.readbyqxmd.com/read/27995807/optimal-scan-timing-for-artery-vein-separation-at-whole-brain-ct-angiography-using-a-320-row-mdct-volume-scanner
#17
Takashi Shirasaka, Akio Hiwatashi, Koji Yamashita, Masatoshi Kondo, Hiroshi Hamasaki, Yamato Shimomiya, Yasuhiko Nakamura, Yoshinori Funama, Hiroshi Honda
OBJECTIVES: A 320-row MDCT is expected for good artery-vein separation in terms of temporal resolution. However, shortened scan duration may lead to insufficient vascular enhancement. We assessed the optimal scan timing for the artery-vein separation at whole-brain CT angiography (CTA) when bolus tracking was used at 320-row MDCT. METHODS: We analyzed 60 patients, who underwent whole-brain four-dimensional CTA. Difference in CT attenuation (Datt) between the internal carotid artery (ICA) and the superior sagittal sinus was calculated in each phase...
December 20, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27995348/mitochondrial-genome-of-pteronotus-personatus-chiroptera-mormoopidae-comparison-with-selected-bats-and-phylogenetic-considerations
#18
Ricardo López-Wilchis, Miguel Ángel Del Río-Portilla, Luis Manuel Guevara-Chumacero
We described the complete mitochondrial genome (mitogenome) of the Wagner's mustached bat, Pteronotus personatus, a species belonging to the family Mormoopidae, and compared it with other published mitogenomes of bats (Chiroptera). The mitogenome of P. personatus was 16,570 bp long and contained a typically conserved structure including 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and one control region (D-loop). Most of the genes were encoded on the H-strand, except for eight tRNA and the ND6 genes...
December 19, 2016: Genetica
https://www.readbyqxmd.com/read/27992208/polymer-vesicle-sensor-for-visual-and-sensitive-detection-of-so2-in-water
#19
Tong Huang, Zhilin Hou, Qingsong Xu, Lei Huang, Chuanlong Li, Yongfeng Zhou
This study reports the first polymer vesicle sensor for the visual detection of SO2 and its derivatives in water. A strong binding ability between tertiary alkanolamines and SO2 has been used as the driving force for the detection by the graft of tertiary amine alcohol (TAA) groups onto an amphiphilic hyperbranched multiarm polymer, which can self-assemble into vesicles with enriched TAA groups on the surface. The polymer vesicles will undergo proton exchange with cresol red (CR) to produce CR-immobilized vesicles (CR@vesicles)...
December 19, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27986316/heavy-metals-removal-using-hydrogel-supported-nanosized-hydrous-ferric-oxide-synthesis-characterization-and-mechanism
#20
Yipin Zhang, Zhengkui Li
A new polymer-supported hybrid adsorbent (HFO-P(TAA/HEA)) for highly efficient removal of Pb(2+), Cu(2+), Cd(2+) and Ni(2+) from wastewater was developed by supporting hydrous ferric oxide (HFO) nanoparticles onto a porous poly(trans-Aconitic acid/2-hydroxyethyl acrylate) hydrogel (P(TAA/HEA)) with in situ precipitation method. Swelling kinetics, scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), Fourier transform infrared spectra (FTIR) and X-ray photoelectron spectroscopy (XPS) were used for characterization of the prepared HFO-P(TAA/HEA)...
December 13, 2016: Science of the Total Environment
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