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https://www.readbyqxmd.com/read/29664296/ppar%C3%AE-mediates-the-hepatoprotective-effects-of-nutmeg
#1
Xiao Nan Yang, Xue-Mei Liu, JIan-He Fang, Xu Zhu, Xiu-Wei Yang, Xue-Rong Xiao, Jian-Feng Huang, Frank J Gonzalez, Fei Li
Nutmeg is a traditional Chinese medicine used to treat gastrointestinal diseases. Some reports indicated that nutmeg has hepatoprotective activity. In this study, a thioacetamide (TAA)-induced acute liver injury model in mice was used to explore the mechanism of the protective effects of nutmeg extract (NME), including its major bioactive component myrislignan. The results indicated that NME could effectively protect TAA-induced liver damage as assessed by recovery of increased serum liver transaminases, decrease hepatic oxidative stress and lower hepatic inflammation...
April 17, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29662844/mineral-elements-bio-accessibility-and-antioxidant-indices-of-blanched-basella-rubra-at-different-phases-of-in-vitro-gastrointestinal-digestion
#2
Sule Ola Salawu, Bukola Eugenia Olukemi, Ikuosho Charity Asikhia, Akintunde Afolabi Akindahunsi
The present investigation was designed to evaluate the mineral element bio-accessibility and antioxidant indices of blanched Basella rubra at different phases of simulated in vitro digestion (oral, gastric, and intestinal). The phenolic composition of processed vegetable was determined using high-performance liquid chromatography (HPLC)-diode-array detection method. Mineral composition, total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power (FRAP), and total antioxidant activity (TAA) of the in vitro digested blanched and raw vegetable were also determined...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29660433/slit2-robo2-signaling-modulates-the-fibrogenic-activity-and-migration-of-hepatic-stellate-cells
#3
Zhiping Zeng, Yujing Wu, Yirong Cao, Ziying Yuan, Yuanqing Zhang, David Y Zhang, Daisuke Hasegawa, Scott L Friedman, Jinsheng Guo
BACKGROUND & AIM: Slit/Robo signaling was originally identified as a repulsive guidance cue in regulating axon branching and neuronal migration. Hepatic stellate cells (HSCs) are the key fibrogenic cells in the liver, which are migratory when activated, and express neural crest markers. The aim of the present study was to investigate the functional significance of Slit/Robo signaling in liver fibrogenesis and in HSCs. KEY FINDINGS: By transcriptomic analysis it was found that axon guidance signaling pathways were significantly upregulated in both diethylnitrosamine (DEN) and thioacetamide (TAA)-induced experimental liver fibrosis...
April 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29656146/genetics-of-the-extracellular-matrix-in-aortic-aneurysmal-diseases
#4
REVIEW
Chien-Jung Lin, Chieh-Yu Lin, Nathan O Stitziel
Aortic aneurysms are morbid conditions that can lead to rupture or dissection and are categorized as thoracic (TAA) or abdominal aortic aneurysms (AAA) depending on their location. While AAA shares overlapping risk factors with atherosclerotic cardiovascular disease, TAA exhibits strong heritability. Human genetic studies in the past two decades have successfully identified numerous genes involved in both familial and sporadic forms of aortic aneurysm. In this review we will discuss the genetic basis of aortic aneurysm, focusing on the extracellular matrix and how insights from these studies have informed our understanding of human biology and disease pathogenesis...
April 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29652187/blood-transfusion-during-total-ankle-arthroplasty-is-associated-with-increased-in-hospital-complications-and-costs
#5
Michael A Ewing, Samuel R Huntley, Dustin K Baker, Kenneth S Smith, Parke W Hudson, Gerald McGwin, Brent A Ponce, Michael D Johnson
INTRODUCTION: Total ankle arthroplasty (TAA) is an increasingly used, effective treatment for end-stage ankle arthritis. Although numerous studies have associated blood transfusion with complications following hip and knee arthroplasty, its effects following TAA are largely unknown. This study uses data from a large, nationally representative database to estimate the association between blood transfusion and inpatient complications and hospital costs following TAA. METHODS: Using the Nationwide Inpatient Sample (NIS) database from 2004 to 2014, 25 412 patients who underwent TAA were identified, with 286 (1...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29629592/revision-of-failed-total-ankle-arthroplasty-to-a-hindfoot-fusion
#6
A A Ali, R A Forrester, P O'Connor, N J Harris
Aims The aim of this study was to present a series of patients with aseptic failure of a total ankle arthroplasty (TAA) who were treated with fusion of the hindfoot using a nail. Patients and Methods A total of 23 TAAs, in 22 patients, were revised for aseptic loosening and balloon osteolysis to a hindfoot fusion by a single surgeon (NH) between January 2012 and August 2014. The procedure was carried out without bone graft using the Phoenix, Biomet Hindfoot Arthrodesis Nail. Preoperative investigations included full blood count, CRP and ESR, and radiological investigations including plain radiographs and CT scans...
April 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29627623/encapsulation-of-trans-aconitic-acid-in-mucoadhesive-microspheres-prolongs-the-anti-inflammatory-effect-in-lps-induced-acute-arthritis
#7
Diego Pinto de Oliveira, Gabriela Guimarães Augusto, Nathália Vieira Batista, Vivian Louise S de Oliveira, Diêgo Santos Ferreira, Mateus Araújo Castro E Souza, Christian Fernandes, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Fernão Castro Braga
trans-Aconitic acid (TAA) is the main constituent of the leaves from the medicinal plant Echinodorus grandiflorus, used to treat different inflammatory diseases. TAA induces a potent but short-lasting biological response, credited to its high polarity and unfavorable pharmacokinetics. Here we developed, characterized and evaluated the anti-inflammatory activity of mucoadhesive microspheres loaded with TAA. Seven batches of mucoadhesive microspheres were prepared by the emulsification/solvent evaporation method, employing different proportions of TAA and Carbopol 934 or/and hydroxypropylmethylcellulose...
April 5, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29622560/role-of-adamts-a-disintegrin-and-metalloproteinase-with-thrombospondin-motifs-5-in-aortic-dilatation-and-extracellular-matrix-remodeling
#8
Marika Fava, Javier Barallobre-Barreiro, Ursula Mayr, Ruifang Lu, Athanasios Didangelos, Ferheen Baig, Marc Lynch, Norman Catibog, Abhishek Joshi, Temo Barwari, Xiaoke Yin, Marjan Jahangiri, Manuel Mayr
OBJECTIVE: Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied by changes in the structure and composition of the aortic ECM (extracellular matrix). The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases has recently been implicated in TAA formation. This study aimed to investigate the contribution of ADAMTS-5 to TAA development. APPROACH AND RESULTS: A model of aortic dilatation by AngII (angiotensin II) infusion was adopted in mice lacking the catalytic domain of ADAMTS-5 (Adamts5Δcat )...
April 5, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29618826/a-systems-pharmacology-oriented-discovery-of-a-new-therapeutic-use-of-the-tcm-formula-liuweiwuling-for-liver-failure
#9
Jia-Bo Wang, He-Rong Cui, Rui-Lin Wang, Cong-En Zhang, Ming Niu, Zhao-Fang Bai, Gen-Hua Xu, Peng-Yan Li, Wen-Yan Jiang, Jing-Jing Han, Xiao Ma, Guang-Ming Cai, Rui-Sheng Li, Li-Ping Zhang, Xiao-He Xiao
Multiple components of traditional Chinese medicine (TCM) formulae determine their treatment targets for multiple diseases as opposed to a particular disease. However, discovering the unexplored therapeutic potential of a TCM formula remains challenging and costly. Inspired by the drug repositioning methodology, we propose an integrated strategy to feasibly identify new therapeutic uses for a formula composed of six herbs, Liuweiwuling. First, we developed a comprehensive systems approach to enrich drug compound-liver disease networks to analyse the major predicted diseases of Liuweiwuling and discover its potential effect on liver failure...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29617761/refining-the-ambush-hypothesis-evidence-that-gc-and-at-rich-bacteria-employ-different-frameshift-defence-strategies
#10
Liam Abrahams, Laurence D Hurst
Stop codons are frequently selected for beyond their regular termination function for error control. The 'ambush hypothesis' proposes out of frame stop codons (OSCs) terminating frameshifted translations are selected for. Although early indirect evidence was partially supportive, recent evidence suggests OSC frequencies are not exceptional when considering underlying nucleotide content. However, prior null tests fail to control amino acid/codon usages or possible local mutational biases. We therefore return to the issue using bacterial genomes, considering several tests defining and testing against a null...
April 2, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29617462/doxorubicin-chemotherapy-affects-the-intracellular-and-interstitial-free-amino-acid-pools-in-skeletal-muscle
#11
Sergio Fabris, David A MacLean
Skeletal muscle (SM) health and integrity is dependent on the dynamic balance between protein synthesis and degradation, and central to this process is the availability of amino acids (AA) in the amino pool. While Doxorubicin (DOX) remains one of the most widely used chemotherapeutic agents for the treatment of solid and hematological malignancies, little is known of the effect of the drug on SM, particularly its effect on the availability of amino acids in the tissue. The purpose of this study was to examine the effect of DOX administration on vascular, interstitial and intracellular concentrations of AA in SM of the rat up to 8 days after the administration of a 1...
2018: PloS One
https://www.readbyqxmd.com/read/29615370/hepatectomy-with-or-without-the-thoraco-abdominal-approach-impact-on-perioperative-outcome
#12
Matteo Donadon, Antonio Mimmo, Davide Cosola, Alfonso Terrone, Fabio Procopio, Daniele Del Fabbro, Matteo Cimino, Luca Viganò, Guido Torzilli
BACKGROUND: Hepatectomy using the thoraco-abdominal approach (TAA) compared to the abdominal approach (AA) remains under debate. This study assessed the perioperative outcomes of patients operated with or without TAA. METHODS: 1:1 propensity score-matched analysis was applied in 744 patients operated between 2007 and 2013, identifying 246 patients who underwent hepatectomy with TAA compared to 246 patients with AA. These groups were matched for demographics, liver disease, comorbidity, tumor features, and extent of resection...
March 31, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29615357/use-of-extracorporeal-bypass-is-associated-with-improved-outcomes-in-open-thoracic-and-thoracoabdominal-aortic-aneurysm-repair
#13
Jahan Mohebali, Stephanie Carvalho, R Todd Lancaster, Emel A Ergul, Mark F Conrad, W Darrin Clouse, Richard P Cambria, Virendra I Patel
OBJECTIVE: There is no consensus on the use or benefit of extracorporeal circulation (EC) during aneurysm repair of the descending thoracic aorta (DTA) or thoracoabdominal aorta (TAA). We evaluated the role of EC during DTA or TAA aneurysm repair using U.S. Medicare data. METHODS: Medicare (2004-2007) patients undergoing open repair of nonruptured DTA or TAA aneurysm were identified by International Classification of Diseases, Ninth Revision code. Specific exclusions included ascending aortic or arch repairs, concomitant cardiac procedures, and procedures employing deep hypothermic circulatory arrest...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29608538/asbestos-fiber-concentrations-in-the-lungs-of-brake-repair-workers-an-updated-analysis-using-several-regression-methods-to-handle-non-detectable-measurements
#14
Yimeng Liu, Gary M Marsh, Victor L Roggli
OBJECTIVES: To reanalyze an updated database of lung asbestos fiber levels for 21 brake repair workers who died of mesothelioma using robust maximum likelihood-based regression methods to address non-detectable measurements. METHODS: We applied bivariate normal regression to address the doubly left-censored situation where both the lung fiber concentration of non-commercial (TAA) and commercial amphiboles (AC) were subject to detection limits. For the single left-censored situation, we applied censored normal regression to study the relationship between duration of employment (DOE) and TAA...
March 30, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29589784/short-term-complications-reoperations-and-radiographic-outcomes-of-a-new-fixed-bearing-total-ankle-arthroplasty
#15
Guilherme H Saito, Austin E Sanders, Cesar de Cesar Netto, Martin J O'Malley, Scott J Ellis, Constantine A Demetracopoulos
BACKGROUND: With the increasing use of total ankle arthroplasty (TAA), new implants with varied configurations are being developed every year. This study aimed to assess the early complications, reoperations, and radiographic and clinical outcomes of the Infinity TAA. To date, clinical results of this novel implant have not been published. METHODS: A retrospective analysis of 64 consecutive ankles that underwent a primary Infinity TAA from July 2014 to April 2016 was performed...
March 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29576698/ameliorative-effect-of-camel-s-milk-and-nigella-sativa-oil-against-thioacetamide-induced-hepatorenal-damage-in-rats
#16
Aftab Ahmad, Fahad A Al-Abbasi, Saida Sadath, Soad Shaker Ali, Mohammed F Abuzinadah, Hani A Alhadrami, Anwar Ali Mohammad Alghamdi, Ali H Aseeri, Shah Alam Khan, Asif Husain
Background: Camel milk (CM) and Nigella sativa (NS) have been traditionally claimed to cure wide range of diseases and used as medicine in different part of world, particularly in Saudi Arabia. Several research studies have been published that proved beneficial effects of CM and NS. Objective: This study was undertaken to investigate the antihepatotxic potential of CM and NS oil (NSO) against thioacetamide (TAA)-induced hepato and nephrotoxicity in rats. Materials and Methods: Thirty female Albino Wistar rats were randomly divided in to six groups having five rats in each group...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29566035/foliar-nitrogen-metabolism-of-adult-douglas-fir-trees-is-affected-by-soil-water-availability-and-varies-little-among-provenances
#17
Baoguo Du, Jürgen Kreuzwieser, Michael Dannenmann, Laura Verena Junker, Anita Kleiber, Moritz Hess, Kirstin Jansen, Monika Eiblmeier, Arthur Gessler, Ulrich Kohnle, Ingo Ensminger, Heinz Rennenberg, Henning Wildhagen
The coniferous forest tree Douglas-fir (Pseudotsuga menziesii) is native to the pacific North America, and is increasingly planted in temperate regions worldwide. Nitrogen (N) metabolism is of great importance for growth, resistance and resilience of trees. In the present study, foliar N metabolism of adult trees of three coastal and one interior provenance of Douglas-fir grown at two common gardens in southwestern Germany (Wiesloch, W; Schluchsee, S) were characterized in two subsequent years. Both the native North American habitats of the seed sources and the common garden sites in Germany differ in climate conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29563135/identification-of-crkii-cfl1-cntn1-nme2-and-tkt-as-novel-and-frequent-t-cell-targets-in-human-idh-mutant-glioma
#18
Steffen Dettling, Slava Stamova, Rolf Warta, Martina Schnölzer, Carmen Rapp, Anchana Rathinasamy, David Reuss, Kolja Pocha, Saskia Roesch, Christine Jungk, Uwe Warnken, Volker Eckstein, Niels Grabe, Christoph Schramm, Markus A Weigand, Andreas von Deimling, Andreas Unterberg, Philipp Beckhove, Christel Herold-Mende
PURPOSE: Successful immunotherapies for IDH mut gliomas require better knowledge of T-cell target antigens. Here, we elucidated their antigen repertoire recognized by spontaneous T-cell responses using an unbiased proteomic approach. EXPERIMENTAL DESIGN: Protein fractionations of tissue lysates from IDH mut gliomas (n=4) were performed. Fractions were tested by IFN-ᵯE; ELISpot assay for recognition through patient's T-cells. Proteins of immunogenic fractions were identified by mass spectrometry and validated by in silico-predicted synthetic long-peptides in patients of origin, additional IDH mut glioma patients (n=16), and healthy donors (n=13)...
March 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29560649/thoracic-aortic-aneurysm-complicated-by-secondary-aortoesophageal-fistula-after-thoracic-endovascular-aortic-repair-a-case-report
#19
R Spitaels, W Jacob, F Janssens, P Schurmans, L Vanmoerkerke, D Walgraeve, J L Coenegrachts
This is a case report of a patient with a thoracic aortic aneurysm (TAA) presenting with dysphagia and weight loss as primary symptoms. She was treated via thoracic endovascular aortic repair (TEVAR). The procedure was complicated with a secondary aortoesophageal fistula (AEF) for which open surgical repair of the esophageal defect was done. Long term (i.e. more than 30 days) antibiotics were given. The recovery was uneventful.
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29560526/total-ankle-replacement-leads-to-high-revision-rates-in-post-traumatic-end-stage-arthrosis
#20
Yves Gramlich, Oliver Neun, Alexander Klug, Johannes Buckup, Thomas Stein, Arvid Neumann, Sebastian Fischer, Hans-Peter Abt, Reinhard Hoffmann
INTRODUCTION: Extremely heterogeneous revision rates in total ankle arthroplasty (TAA) of the upper ankle joint are reported and result to heterogeneous collectives and to short follow-up times. The aim is to investigate revision rates and the underlying reasons, as well as treatment outcome and quality of life after TAA in post-traumatic cases with sufficient follow-up. METHODS: In 2008-2013, 74 patients with post-traumatic arthrosis were treated using TAA with a Tornier Salto prosthesis, and 60 (35 males and 25 females; mean age 56) were followed-up (mean: 59 months; range 24-91 months)...
March 20, 2018: International Orthopaedics
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