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Larynx cancer

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https://www.readbyqxmd.com/read/29135033/primary-and-salvage-laser-surgery-of-341-glottic-cancers-comparison-of-treatment-outcomes-between-university-head-neck-tertiary-referral-center-and-local-head-neck-department
#1
Piotr Winiarski, Artur Lewandowski, Grażyna Greczka, Jacek Banaszewski, Hanna Klimza, Małgorzata Wierzbicka
OBJECTIVE: The main goal was to compare the clinical data of patients with T1 and T2 glottic cancer treated with CO2 transoral laser microlaryngoscopy (TLM) in the Tertiary Referral University Department of Otolaryngology, Head Neck Surgery, Poznan and the local Department of Otolaryngology, Oncology and Maxillofacial Surgery, Bydgoszcz. MATERIAL AND METHODS: Unified databases for the 7-year period January 2005-December 2011 were created to compare these two cohorts...
November 14, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29134827/serum-plasma-and-saliva-biomarkers-for-head-and-neck-cancer
#2
Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Matias Eliseo Melendez, André Lopes Carvalho
Head and neck squamous cell carcinoma (HNSCC) encompasses tumors arising from several locations (oral and nasal cavities, paranasal sinuses, salivary glands, pharynx, and larynx) and currently stands as the sixth most common cancer worldwide. The most important risk factors identified so far are tobacco and alcohol consumption, and, for a subgroup of HNSCCs, infection with high-risk types of human papillomavirus (HPV). Despite several improvements in the treatment of these tumors in the last decades, overall survival rates have only improved marginally, mainly due to the advanced clinical stage at diagnosis and the high rates of treatment failure associated with this late diagnosis...
November 14, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29126495/surgical-management-of-oral-cancer
#3
REVIEW
Rabie M Shanti, Bert W O'Malley
Today, most head and neck cancer subsites, such as the larynx, hypopharynx, nasopharynx, and oropharynx, are treated with radiation therapy with or without chemotherapy as a primary treatment modality. Surgery is reserved for the salvage of recurrent tumors that occur within the head and neck in the absence of distant (ie, lung, liver) metastasis. However, unlike all other head and neck subsites, oral cancer should ideally be managed with primary surgery with the possibility of adjuvant radiation therapy with or without chemotherapy depending on the presence of certain high-risk pathologic features...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29119762/-mortality-study-update-of-workers-exposed-to-vinyl-chloride-in-plants-located-in-ferrara-and-ravenna-emilia-romagna-region-northern-italy
#4
Corrado Scarnato, Rossella Rambaldi, Gianpiero Mancini, Sandra Olanda, Maria Rosa Spagnolo, Elisabetta Previati, Valerio Parmeggiani, Salvatore Minisci, Pietro Comba, Roberta Pirastu
OBJECTIVES: to update the mortality study of subjects exposed to vinyl chloride in the phases of synthesis of the monomer and polymerization in the plants of Ferrara and Ravenna (Emilia-Romagna Region, Northern Italy). DESIGN: both for the whole cohort and for the two plants, standardized mortality ratios (SMRs), with 95% confidence intervals (95%CI), were calculated for different death causes, then stratified by duration and latency, periods of the beginning of work and cumulative exposure (ppm-years)...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29116044/the-predictive-value-of-videostroboscopy-in-the-assessment-of-premalignant-lesions-and-early-glottis-cancers
#5
Anna Rzepakowska, Ewelina Sielska-Badurek, Ewa Osuch-Wójcikiewicz, Maria Sobol, Kazimierz Niemczyk
OBJECTIVE: To assess the sensitivity and specificity of larngovideostroboscopy (LVS) in the diagnosis of precancerous and malignant lesions of the vocal folds. MATERIAL AND METHODS: In 175 patients (128 men and 47 women), aged 19-88 years, mean age 61.5, who were admitted to the clinic with diagnosed premalignant conditions of vocal fold mucosa (leukoplakia, chronic hypertrophic inflammatory lesions) and thickening or tumor on the vocal fold, there was performed LVS before the laryngeal microsurgery...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29114897/development-and-external-validation-of-a-risk-prediction-model-to-predict-5-year-overall-survival-in-advanced-larynx-cancer
#6
Japke F Petersen, Martijn M Stuiver, Adriana J Timmermans, Amy Chen, Hongzhen Zhang, James P O'Neill, Sandra Deady, Vincent Vander Poorten, Jeroen Meulemans, Johan Wennerberg, Carl Skroder, Andrew T Day, Wayne Koch, Michiel W M van den Brekel
OBJECTIVES/HYPOTHESIS: TNM-classification inadequately estimates patient-specific overall survival (OS). We aimed to improve this by developing a risk-prediction model for patients with advanced larynx cancer. STUDY DESIGN: Cohort study. METHODS: We developed a risk prediction model to estimate the 5-year OS rate based on a cohort of 3,442 patients with T3T4N0N+M0 larynx cancer. The model was internally validated using bootstrapping samples and externally validated on patient data from five external centers (n = 770)...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29111339/combined-vocal-exercises-for-rehabilitation-after-supracricoid-laryngectomy-evaluation-of-different-execution-times
#7
Hevely Saray Lima Silveira, Marcia Simões-Zenari, Marco Aurélio Kulcsar, Claudio Roberto Cernea, Kátia Nemr
INTRODUCTION: The supracricoid partial laryngectomy allows the preservation of laryngeal functions with good local cancer control. OBJECTIVE: To assess laryngeal configuration and voice analysis data following the performance of a combination of two vocal exercises: the prolonged /b/vocal exercise combined with the vowel /e/ using chest and arm pushing with different durations among individuals who have undergone supracricoid laryngectomy. METHODS: Eleven patients undergoing partial laryngectomy supracricoid with cricohyoidoepiglottopexy (CHEP) were evaluated using voice recording...
October 27, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29110635/a-modified-endoscopic-submucosal-dissection-for-a-superficial-hypopharyngeal-cancer-a-case-report-and-technical-discussion
#8
Lianjun Di, Kuang-I Fu, Rui Xie, Xinglong Wu, Youfeng Li, Huichao Wu, Biguang Tuo
BACKGROUND: Adequate working space and a clear view for the dissected lesion are crucial for endoscopic submucosal dissection (ESD). Pharyngeal ESD requires that an otorhinolaryngologist creates working space by lifting the larynx with a curved laryngoscope. However, many countries do not have this kind of curved laryngoscope, and the devices could interfere with endoscope because of the narrow space of the pharynx. To overcome these issues, we used a transparent hood (Elastic Touch, slit and hole type, M (long), Top company, Tokyo Japan) instead of the curved laryngoscope to create adequate working space by pushing the larynx, and pharyngeal ESD could be done by gastroenterologists...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29092098/differentiated-and-anaplastic-thyroid-carcinoma-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#9
REVIEW
Nancy D Perrier, James D Brierley, R Michael Tuttle
Answer questions and earn CME/CNE This is a review of the major changes in the American Joint Committee on Cancer staging manual, eighth edition, for differentiated and anaplastic thyroid carcinoma. All patients younger than 55 years have stage I disease unless they have distant metastases, in which case, their disease is stage II. In patients aged 55 years or older, the presence of distant metastases confers stage IVB, while cases without distant metastases are further categorized based on the presence/absence of gross extrathyroidal extension, tumor size, and lymph node status...
November 1, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29080963/trends-in-treatment-incidence-and-survival-of-hypopharynx-cancer-a-20-year-population-based-study-in-the-netherlands
#10
Japke F Petersen, Adriana J Timmermans, Boukje A C van Dijk, Lucy I H Overbeek, Laura A Smit, Frans J M Hilgers, Martijn M Stuiver, Michiel W M van den Brekel
Hypopharynx cancer has the worst prognosis of all head and neck squamous cell cancers. Since the 1990s, a treatment shift has appeared from a total laryngectomy towards organ preservation therapies. Large randomized trials evaluating treatment strategies for hypopharynx cancer, however, remain scarce, and frequently this malignancy is evaluated together with larynx cancer. Therefore, our aim was to determine trends in incidence, treatment and survival of hypopharynx cancer. We performed a population-based cohort study including all patients diagnosed with T1-T4 hypopharynx cancer between 1991 and 2010 in the Netherlands...
October 28, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29075744/multidisciplinary-clinic-management-of-head-and-neck-cancer
#11
Melanie Townsend, Dorina Kallogjeri, Nicholas Scott-Wittenborn, Katherine Gerull, Stacy Jansen, Brian Nussenbaum
Importance: Contemporary management of head and neck cancer involves professionals from multiple specializations. Streamlined care that reduces delays yet allows for comprehensive evaluation is needed. Objective: To evaluate a single-day, single-appointment, multidisciplinary head and neck clinic model for reduction in treatment delay and comprehensiveness of care. Design, Setting, and Participants: A retrospective cohort analysis was conducted from June 1, 2015, to July 31, 2016, of outpatients at a single, academic medical center...
October 26, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29065867/the-relative-risk-of-second-primary-cancers-in-austria-s-western-states-a-retrospective-cohort-study
#12
Oliver Preyer, Nicole Concin, Andreas Obermair, Hans Concin, Hanno Ulmer, Willi Oberaigner
BACKGROUND: Cancer survivors are at risk of developing a second primary cancer (SPC) later in life because of persisting effects of genetic and behavioural risk factors, the long-term sequelae of chemotherapy, radiotherapy and the passage of time. This is the first study with Austrian data on an array of entities, estimating the risk of SPCs in a population-based study by calculating standardized incidence ratios (SIRs). METHODS: This retrospective cohort study included all invasive incident cancer cases diagnosed within the years 1988 to 2005 being registered in the Tyrol and Vorarlberg Cancer Registries...
October 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29060832/a-bioimpedance-sensing-system-for-in-vivo-cancer-tissue-identification-design-and-preliminary-evaluation
#13
Camilla Carpano Maglioli, Darwin G Caldwell, Leonardo S Mattos
Bioimpedance evaluation can provide useful information for biological tissue characterization and potentially allows the identification of pathological areas within a tissue in-vivo. In this study a new needle-based bioimpedance sensing system was designed and developed to provide such capability considering intra-operative detection of cancerous tissue in the larynx as the primary specific application. The system is small, low-power, fully embedded in a printed circuit board and based on a disposable concentric electrode needle...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29049434/survival-outcomes-for-patients-with-t3n0m0-squamous-cell-carcinoma-of-the-glottic-larynx
#14
Huaising C Ko, Paul M Harari, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Randall J Kimple, Matthew E Witek
Importance: Radiotherapy (RT)-based organ preservation approaches for patients with advanced laryngeal cancer have been established stepwise through prospective randomized clinical trials. However, broad adoption of these approaches has stimulated discussion about long-term results challenging their applicability in a heterogeneous patient population, most recently for patients with T3 disease. Objective: To define outcomes in patients with clinical T3N0M0 glottic laryngeal cancer treated with definitive surgical and RT-based approaches...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29034666/-respiratory-cancers-attributable-to-occupational-exposures-what-is-the-cost-to-society-in-france
#15
Hassan Serrier, Hélène Sultan-Taïeb, Danièle Luce, Sophie Béjean
OBJECTIVE: To estimate the social cost of respiratory cancers attributable to occupational risk factors in France in 2010. METHODS: We estimated the number of cases of respiratory cancers attributable to each identified occupational risk factor according to the attributable fractions method. We also estimated direct (costs of hospital stays, drugs, outpatient care) and indirect costs (production losses) related to morbidity (absenteeism and presenteeism) and mortality (years of lost production)...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#16
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29027001/cancer-incidence-in-urban-rural-and-densely-populated-districts-close-to-core-cities-in-bavaria-germany
#17
M Radespiel-Tröger, K Geiss, D Twardella, W Maier, M Meyer
OBJECTIVE: An ecologic study on the level of districts was performed to evaluate the possible association between district type and risk of cancer in Bavaria, Southern Germany. METHODS: Cancer incidence data for the years 2003-2012 were obtained from the population-based cancer registry Bavaria according to sex and cancer site. Data on district type, socio-economic area deprivation, particulate matter exposure, tobacco consumption, and alcohol consumption were obtained from publicly available sources...
October 12, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29025048/meta-analysis-of-occupational-exposures-in-the-rubber-manufacturing-industry-and-risk-of-cancer
#18
Mathieu Boniol, Alice Koechlin, Peter Boyle
Background: : Occupational exposures in the rubber manufacturing industry showed an increased risk of cancer and have been classified as a group 1 carcinogen, largely from studies on workers employed before 1950s. Cancer sites considered as causally associated are bladder, lung and stomach, and leukaemia. Recent studies did not report an increased risk of cancer. Methods: A meta-analysis was conducted on observational studies published until April 2016 on occupational exposures in the rubber manufacturing industry and risk of cancer...
July 26, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29022097/prevalence-of-fibroblast-growth-factor-receptor-1-fgfr1-amplification-in-squamous-cell-carcinomas-of-the-head-and-neck
#19
Till Sebastian Clauditz, Arne Böttcher, Henning Hanken, Kerstin Borgmann, Guido Sauter, Waldemar Wilczak, Tobias Grob, Adrian Münscher
BACKGROUND: FGFR1 is a receptor tyrosine kinases involved in tumor growth signaling, survival, and differentiation in many solid cancer types. There is growing evidence that FGFR1 amplification might predict therapy response to FGFR1 inhibitors in squamous cell lung cancers. To estimate the potential applicability of anti FGFR1 therapies in squamous cell carcinomas of the head and neck, we studied patterns of FGFR1 amplification using fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: A tissue microarray was constructed from 453 primary treatment-naive squamous cell carcinomas of the head and neck regions with histopathological and clinical follow-up data [including oral cavity (n = 222), oropharynx (n = 126), and larynx (n = 105)]...
October 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29019541/laryngeal-chondroradionecrosis-following-radiotherapy
#20
Giulianno Molina Melo, Paula Demetrio Souza, Luiz Castro Bastos, Murilo Catafesta Neves, Kleber Simões do Espirito Santo, Onivaldo Cervantes, Márcio Abrahão
OBJECTIVE: to study larynx chondroradionecrosis related to radiotherapy and chemotherapy treatment and provide a treatment flowchart. METHODS: retrospective study with clinical data analysis of all larynx cancer patients admitted in a two tertiary hospital in a five years period. RESULTS: from 131 patients treated for larynx cancer, 28 underwent chemoradiotherapy with curative intent and three of them presented chondroradionecrosis. They were treated with hiperbaric oxigen therapy and surgical debridment following our flowchart, preserving the larynx in all...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
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