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REVIEW
Ahmad Abid, Huzaifa Piperdi, Mustufa Babar, Justin Loloi, Ahmed Moutwakil, Umair Azhar, Pedro Maria, Alexander Small
BACKGROUND: Geriatric patients, prone to adverse events (AEs) and low compliance with drugs, may benefit from minimally invasive surgical therapies (MISTs) for managing benign prostatic hyperplasia (BPH). We evaluated the efficacy, safety, and procedural characteristics of MISTs in geriatric patients with BPH. METHODS: PubMed/MEDLINE database was systematically searched for relevant articles through October 1, 2023. Eligible studies focused on geriatric patients (≥65 years) with BPH who were treated with MISTs and evaluated follow-up surgical, micturition, and/or sexual outcomes...
April 24, 2024: Prostate
#22
RANDOMIZED CONTROLLED TRIAL
Dihui Lai, Shaowei Cheng, Shaona Zhou, Jianchun Hao, Hongguang Chen, Kang Jia, Hongmei Liu, Yong Cui
PURPOSE: Melasma remains a refractory skin condition that needs to be actively explored. Azelaic acid has been used for decades as a topical agent to improve melasma through multiple mechanisms, however, there is a lack of research on its combination with laser therapy. This study evaluated the effectiveness of isolated treatment with topical 20% azelaic acid and its combination with 755-nm picosecond laser in facial melasma patients. METHODS: A randomized, evaluator-blinded, controlled study was conducted on 30 subjects with facial melasma in a single center from October 2021 to April 2022...
April 24, 2024: Lasers in Medical Science
#23
JOURNAL ARTICLE
Naoto Wakabayashi, Shiro Watanabe, Takashige Abe, Junki Takenaka, Kenji Hirata, Rina Kimura, Keita Sakamoto, Nobuo Shinohara, Kohsuke Kudo
OBJECTIVE: To investigate the incidence of adverse events (AEs) following single and multiple administrations of I-131 metaiodobenzylguanidine (MIBG) therapy for inoperable pheochromocytomas and paragangliomas (PPGLs). METHODS: A single-center retrospective study was conducted on patients with inoperable PPGLs who underwent I-131 MIBG therapy between January 2000 and December 2020. A total of 28 patients with available electronic medical records were included. The treatment consisted of a single intravenous administration of 150 mCi (5...
April 24, 2024: Annals of Nuclear Medicine
#24
JOURNAL ARTICLE
Dunia Alarkawi, Thach S Tran, Weiwen Chen, Lyn M March, Fiona M Blyth, Robert D Blank, Dana Bliuc, Jacqueline R Center
IMPORTANCE: A high proportion of patients who sustain a fracture have multimorbidity. However, the association of multimorbidity with postfracture adverse outcomes, such as subsequent fractures and premature mortality, has not been widely explored. OBJECTIVE: To examine the association of multimorbidity and self-rated health with subsequent fractures and mortality after fracture. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study included participants from New South Wales, Australia, in the Sax Institute's 45 and Up Study (n = 267 357)...
April 1, 2024: JAMA Network Open
#25
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Cancer Medicine
#26
JOURNAL ARTICLE
Michel Pieren, Ana Abáigar Gutiérrez-Solana, Rosa María Antonijoan Arbós, Gary W Boyle, Myriam Davila, Maria Davy, Marc Gitzinger, Lisa Husband, María S Martínez-Martínez, Dolores Ochoa Mazarro, Eleni Pefani, Sophie L Penman, Modesto J Remuiñán, Georgios Vlasakakis, Markus Zeitlinger, Glenn E Dale
BACKGROUND: The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. OBJECTIVES: A Phase 1, double-blind, randomized, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics (PK) and food effect of alpibectir administered as single and multiple oral doses in healthy volunteers (NCT04654143). METHODS: Eighty participants were randomized...
April 24, 2024: Journal of Antimicrobial Chemotherapy
#27
JOURNAL ARTICLE
Randall Rojas-Vásquez, Alejandro Hernández-Soto, Griselda Arrieta-Espinoza, Andrés Gatica-Arias
Tissue culture optimization protocols limit indica rice breeding. Such a challenge is vital because emergent techniques still rely on tissue culture methods and could allow the breeding of new varieties with higher production and toleration of adverse environmental effects caused by climate change. Genome editing technology, using CRISPR/Cas9, is a fast and precise method for accelerated plant breeding. It limited its use in indica subspecies because of the recalcitrant response to in vitro culture methods...
2024: Methods in Molecular Biology
#28
JOURNAL ARTICLE
Bradley J Till, José P Jiménez-Madrigal, Andrés Gatica-Arias
Treatment of plants with chemical mutagens results primarily in the production of novel single nucleotide variants. Mutagenesis is a mostly random process and as such plants derived from mutagenesis of different seeds or in vitro material are expected to accumulate different mutations. An important step in the creation of a mutant population for forward or reverse genetics is the choice of treatment conditions (e.g., dosage) such that sufficient mutations accumulate while not adversely affecting propagation of the plant...
2024: Methods in Molecular Biology
#29
JOURNAL ARTICLE
Saroj Kumari Meena, Rajnish Gupta, Manmohan Puri
Asthma and obstructive sleep apnea (OSA) are commonly prevalent diseases, and both can co-exist to result in an alternate overlap syndrome, where a bidirectional relationship can adversely affect each other. This study aimed to determine the existence and pattern of sleep-related breathing disorders in subjects with bronchial asthma. It was prospectively conducted at the National Institute of Tuberculosis and Respiratory Diseases, New Delhi, in diagnosed cases of bronchial asthma. A subjective assessment of sleepiness was done using the Epworth sleepiness scale (ESS)...
April 23, 2024: Monaldi Archives for Chest Disease
#30
JOURNAL ARTICLE
Richard A Bryant, Suzanna Azevedo, Srishti Yadav, Catherine Cahill, Lucy Kenny, Fiona Maccallum, Jenny Tran, Jasmine Choi-Christou, Natasha Rawson, Julia Tockar, Benjamin Garber, Dharani Keyan, Katie S Dawson
IMPORTANCE: Although grief-focused cognitive behavior therapies are the most empirically supported treatment for prolonged grief disorder, many people find this treatment difficult. A viable alternative for treatment is mindfulness-based cognitive therapy. OBJECTIVE: To examine the relative efficacies of grief-focused cognitive behavior therapy and mindfulness-based cognitive therapy to reduce prolonged grief disorder severity. DESIGN, SETTING, AND PARTICIPANTS: A single-blind, parallel, randomized clinical trial was conducted among adults aged 18 to 70 years with prolonged grief disorder, as defined in the International Classification of Diseases, 11th Revision, and assessed by clinical interview based on the Prolonged Grief-13 (PG-13) scale...
April 24, 2024: JAMA Psychiatry
#31
JOURNAL ARTICLE
Uwe Zeymer, Robert Groves, Stephan Hupfer
BACKGROUND: Sacubitril/valsartan (Sac/Val) is the first angiotensin receptor-neprilysin inhibitor indicated for symptomatic chronic heart failure (HF) with reduced ejection fraction (HFrEF). Given most patients with HF in Germany are managed by general practitioners, AURORA-HF investigated the baseline characteristics and 1‑year follow-up of patients starting Sac/Val in primary care in Germany. METHODS: This was a prospective, multicenter, observational study, with all treatment decisions independent of participation...
April 24, 2024: Herz
#32
REVIEW
Omar Nasher, Nigel J Hall, Rajnikant Mehta, Yousef El-Gohary, Marian Knight
PURPOSE: This study aims to evaluate different surgical approaches to long-gap esophageal atresia (LGEA) with or without tracheoesophageal fistula (TEF) is unclear. METHODS: A systematic literature review was done comparing gastric transposition versus esophageal lengthening with delayed primary anastomosis in infants with LGEA+/-TEF. The primary outcome was time to full oral feeds. Secondary outcomes were time to full enteric feeds, need for further surgery, growth, mortality, and postoperative adverse events...
April 24, 2024: Pediatric Surgery International
#33
JOURNAL ARTICLE
Greg Noe, Kaushal Shah, Samantha Ongchuan, Sahil Munjal
BACKGROUND: Among prescribers, bupropion is considered a substance of low misuse potential, with some studies showing lesser misuse potential than caffeine. However, several case reports exist of recreational bupropion misuse and diversion. Our goal is to understand at-risk populations, clinical courses, interventions, and outcomes after acute ingestion of bupropion via oral, intravenous route, and insufflation. METHODS: The systematic review was registered with PROSPERO on August 5, 2023...
April 24, 2024: Journal of Clinical Psychopharmacology
#34
JOURNAL ARTICLE
McKenzie A Dirr, Areeba Ahmed, Daniel I Schlessinger, Misha Haq, Victoria Shi, Eric Koza, Melissa Ma, Rachel E Christensen, Sarah A Ibrahim, Jochen Schmitt, Lena Johannsen, Yuka Asai, Hilary E Baldwin, Enzo Berardesca, Brian Berman, Ana Carolina Vieira, Anna L Chien, David E Cohen, James Q Del Rosso, Jacquelyn Dosal, Lynn A Drake, Steven R Feldman, Alan B Fleischer, Adam Friedman, Emmy Graber, Julie C Harper, Yolanda R Helfrich, Gregor B Jemec, Sandra M Johnson, Rajani Katta, Peter Lio, Lisa E Maier, George Martin, Arielle R Nagler, Isaac M Neuhaus, Melis Palamar, Lawrence C Parish, Theodore Rosen, Stephen P Shumack, James A Solomon, Emil A Tanghetti, Guy F Webster, Allison Weinkle, Jonathan S Weiss, Edward J Wladis, Ian A Maher, Joseph F Sobanko, Todd V Cartee, Brian A Cahn, Murad Alam, Bianca Y Kang, Sanjana Iyengar, Noor Anvery, Erkan Alpsoy, Anthony Bewley, Clio Dessinioti, Alexander Egeberg, Burhan Engin, Harald P M Gollnick, Dimitrios Ioannides, Hei Sung Kim, Elizabeth Lazaridou, Ji Li, Hester Gail Lim, Giuseppe Micali, Clivia Maria Moraes de Oliveira, Lucero Noguera-Morel, Aurora Parodi, Markus Reinholz, Dae Hun Suh, Qiuning Sun, Esther J van Zuuren, Uwe Wollina, Youwen Zhou, Catherine Zip, Emily Poon, Ross Pearlman
IMPORTANCE: Inconsistent reporting of outcomes in clinical trials of rosacea is impeding and likely preventing accurate data pooling and meta-analyses. There is a need for standardization of outcomes assessed during intervention trials of rosacea. OBJECTIVE: To develop a rosacea core outcome set (COS) based on key domains that are globally relevant and applicable to all demographic groups to be used as a minimum list of outcomes for reporting by rosacea clinical trials, and when appropriate, in clinical practice...
April 24, 2024: JAMA Dermatology
#35
JOURNAL ARTICLE
Yan-Jing Zeng, Jun Zhang, Yan-Fang Li, Yu-Yi Chen
A high systolic/diastolic (S/D) ratio of umbilical cord blood is a manifestation of intrauterine hypoxia. However, the clinical significance of a persistently decreased S/D ratio of umbilical cord blood has not been reported. We report eight cases of a persistently decreased S/D ratio of umbilical cord blood, with two cases of umbilical thrombus, five cases of excessive torsion, and one case of a true cord knot. Fetuses with a persistently decreased S/D ratio of umbilical cord blood may be at risk, and it may be an important indication of umbilical cord lesions...
April 2024: Journal of International Medical Research
#36
JOURNAL ARTICLE
Yangyang Yang, Xiaoyan Yin, Yuanzhuo Zhang, Lei Ren
PURPOSE: Construction of a prediction model to predict the risk of major adverse cardiovascular events (MACE) in the long term after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). METHOD: Retrospective analysis of STEMI patients treated with PCI from April 2018 to April 2021 in Fuyang People's Hospital. Lasso regression was used to screen the risk factors for the first occurrence of MACE in patients, and multifactorial logistic regression analysis was used to construct a prediction model...
April 25, 2024: Coronary Artery Disease
#37
JOURNAL ARTICLE
Filippo D'Amico, Alessandro Pruna, Zbigniew Putowski, Sara Dormio, Silvia Ajello, Anna Mara Scandroglio, Todd C Lee, Alberto Zangrillo, Giovanni Landoni
OBJECTIVES: Hypotension is associated with adverse outcomes in critically ill and perioperative patients. However, these assumptions are supported by observational studies. This meta-analysis of randomized controlled trials aims to compare the impact of lower versus higher blood pressure targets on mortality. DATA SOURCES: We searched PubMed, Cochrane, and Scholar from inception to February 10, 2024. STUDY SELECTION: Randomized trials comparing lower versus higher blood pressure targets in the management of critically ill and perioperative settings...
April 24, 2024: Critical Care Medicine
#38
JOURNAL ARTICLE
Reem Almutairy, Mansoor Ahmed Khan, Alaa Shahbar, Mohammed Aseeri, Majed Alshamrani, Hassan Almarhabi, Doaa Naeem
INTRODUCTION: The incidence of invasive fungal diseases (IFDs) has risen in hematologic malignancy patients due to neutropenia. While posaconazole is recommended as the first-line antifungal prophylaxis in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients and voriconazole is an alternative, there is currently no direct comparison data available to assess their relative effectiveness. METHOD: We retrospectively reviewed eligible patient charts from January 2017 to February 2019 to identify breakthrough IFD rates, drug adverse event frequency, and drug acquisition cost in AML/MDS patients...
April 24, 2024: Journal of Oncology Pharmacy Practice
#39
JOURNAL ARTICLE
Zheng Lv, Xuan Zhang, Kelei Zhao, Lianming Du, Xinrong Wang, Yiwen Chu, Ting Huang
Klebsiella pneumoniae is an important gram-negative bacterium that causes severe respiratory and healthcare-associated infections. Although antibiotic therapy is applied to treat severe infections caused by K. pneumoniae , drug-resistant isolates pose a huge challenge to clinical practices owing to adverse reactions and the mismanagement of antibiotics. Several studies have attempted to develop vaccines against K. pneumoniae , but there are no licensed vaccines available for the control of K. pneumoniae infection...
December 2024: Virulence
#40
REVIEW
Azalea Uva, Sofia Michailovich, Nathan Sung Yuan Hsu, Helen Tran
The integration of next-generation electronics into society is rapidly reshaping our daily interactions and lifestyles, revolutionizing communication and engagement with the world. Future electronics promise stimuli-responsive features and enhanced biocompatibility, such as skin-like health monitors and sensors embedded in food packaging, transforming healthcare and reducing food waste. Imparting degradability may reduce the adverse environmental impact of next-generation electronics and lead to opportunities for environmental and health monitoring...
April 24, 2024: Journal of the American Chemical Society
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