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https://www.readbyqxmd.com/read/29353413/exploring-the-genetic-and-adaptive-diversity-of-a-pan-mediterranean-crop-wild-relative-narrow-leafed-lupin
#1
Mahsa Mousavi-Derazmahalleh, Philipp E Bayer, Bruno Nevado, Bhavna Hurgobin, Dmitry Filatov, Andrzej Kilian, Lars G Kamphuis, Karam B Singh, Jens D Berger, James K Hane, David Edwards, William Erskine, Matthew N Nelson
This first pan-Mediterranean analysis of genetic diversity in wild narrow-leafed lupin revealed strong East-West genetic differentiation of populations, an historic eastward migration, and signatures of genetic adaptation to climatic variables. Most grain crops suffer from a narrow genetic base, which limits their potential for adapting to new challenges such as increased stresses associated with climate change. Plant breeders are returning to the wild ancestors of crops and their close relatives to broaden the genetic base of their crops...
January 20, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29353300/empirical-validation-of-the-crafft-abuse-screening-test-in-a-spanish-sample
#2
Antonio Rial, Sion Kim-Harris, John R Knight, Manuel Araujo, Patricia Gómez, Teresa Braña, Jesús Varela, Sandra Golpe
The CRAFFT Substance Abuse Screening Instrument, developed by the Center for Adolescents Substance Abuse Research (CeASAR) (Knight et al., 1999), is a screening tool for high-risk alcohol and drug risk consumption designed for use with adolescents. Since its publication it has been the subject of translations and validations in different countries, populations and contexts that have demonstrated its enormous potential. However, there is still no empirical validation study that would ensure its good psychometric performance in Spain...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29353298/development-and-validation-of-the-marijuana-motives-measure-short-form
#3
Laura Mezquita, Lucía Ruiz-Valero, Naiara Martínez-Gómez, Manuel I Ibáñez, Generós Ortet
Marijuana motives are a proximal variable to marijuana use. This research aimed to adapt and validate the short form of the Marijuana Motives Measure (MMM; Simons, Correia, Carey, y Borsari, 1998), the MMM SF, in Spanish.  The sample comprised 232 participants (mean age = 25.11 (7.58), 50.43% males) who had tried marijuana at least once in their lifetime. Item and Rasch analyses were performed to choose the final pool of 15 items. Confirmatory Factor Analysis (CFA) showed an adequate 5-factor structure (S-BX2(80) = 121...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29353216/an-efficient-swarm-intelligence-approach-to-feature-selection-based-on-invasive-weed-optimization-application-to-multivariate-calibration-and-classification-using-spectroscopic-data
#4
Saheleh Sheykhizadeh, Abdolhossein Naseri
Variable selection plays a key role in classification and multivariate calibration. Variable selection methods are aimed at choosing a set of variables, from a large pool of available predictors, relevant to the analyte concentrations estimation, or to achieve better classification results. Many variable selection techniques have now been introduced among which, those which are based on the methodologies of swarm intelligence optimization have been more respected during a few last decades since they are mainly inspired by nature...
January 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29353197/bioanalytical-assessment-of-adaptive-stress-responses-in-drinking-water-a-predictive-tool-to-differentiate-between-micropollutants-and-disinfection-by-products
#5
Armelle Hebert, Cedric Feliers, Caroline Lecarpentier, Peta A Neale, Rita Schlichting, Sylvie Thibert, Beate I Escher
Drinking water can contain low levels of micropollutants, as well as disinfection by-products (DBPs) that form from the reaction of disinfectants with organic and inorganic matter in water. Due to the complex mixture of trace chemicals in drinking water, targeted chemical analysis alone is not sufficient for monitoring. The current study aimed to apply in vitro bioassays indicative of adaptive stress responses to monitor the toxicological profiles and the formation of DBPs in three drinking water distribution systems in France...
January 3, 2018: Water Research
https://www.readbyqxmd.com/read/29353173/use-of-cu-zn-superoxide-dismutase-tool-for-biomonitoring-marine-environment-pollution-in-the-persian-gulf-and-the-gulf-of-oman
#6
Farrokhzad Zeinali, Ahmad Homaei, Ehsan Kamrani, Seema Patel
Superoxide dismutase (SOD) is the pivotal antioxidant enzyme that defends organisms against the oxidative stresses of superoxide radicals. In this experimental study, purification of SOD from the leaves of Avicennia marina (grey mangrove or white mangrove) from the family Acanthaceae, located in Sirik mangrove forest on the shore of the Gulf of Oman was performed, for the intended characterization of SOD. The Sirik AmSOD (A. marina SOD) expressed optimum activity in the pH range of 6-9 with the maximum activity at pH 8...
January 16, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29353170/transgenerational-effects-of-ocean-warming-on-the-sea-urchin-strongylocentrotus-intermedius
#7
Chong Zhao, Lisheng Zhang, Dongtao Shi, Jingyun Ding, Donghong Yin, Jiangnan Sun, Baojing Zhang, Lingling Zhang, Yaqing Chang
Transgenerational effects, which involve both selection and plasticity, are important for the evolutionary adaptation of echinoderms in the changing ocean. Here, we investigated the effects of breeding design and water temperature for offspring on fertilization, hatchability, larval survival, size, abnormality and metamorphosis of the sea urchin Strongylocentrotus intermedius, whose dams and sires were exposed to long-term (~15 months) elevated temperature (~3°C above ambient) or ambient temperature. There was no transgenerational effect on fertilization and metamorphosis of S...
January 17, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29353092/individual-and-dyadic-rope-turning-as-a-window-into-social-coordination
#8
Raoul Huys, Agnieszka Kolodziej, Julien Lagarde, Chlöé Farrer, Robert Darmana, Pier-Giorgio Zanone
The spontaneous and intentional movement coordination between peoples is well understood. Less is known about such interactions when the coordination is subordinate to the task and when the task involves, next to vision, mechanically induced haptic and kinesthetic coupling between dyadic partners. We therefore investigated dyadic jump rope turning. Fifteen dyadic pairs conjointly turned a jump rope to which five markers were equidistantly attached, and whose movements were recorded in 3D. In addition, each participant turned one side of the rope while the other side was quasi-fixed in an individual baseline condition...
January 16, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29353083/combining-ultrasound-and-intratumoral-administration-of-doxorubicin-loaded-microspheres-to-enhance-tumor-cell-killing
#9
Anh-Vu Do, Sean M Geary, Dongrim Seol, Phillip Tobias, Daniel Carlsen, Nattawut Leelakanok, James A Martin, Aliasger K Salem
Melanoma is an incurable disease for which alternative treatments to chemotherapy alone are sought. Here, using a melanoma model, we investigated the antitumor potential of combining ultrasound (US) with poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with doxorubicin (DOX). The aim was to achieve synergistic tumoricidal activity through direct and indirect US-mediated damage of tumor cells combined with sustained and potentially controllable release (when combined with US) of DOX from microspheres...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29353080/atlantic-salmon-adapted-to-seawater-for-9-weeks-develop-a-robust-immune-response-to-salmonid-alphavirus-upon-bath-challenge
#10
L J Moore, J Jarungsriapisit, T O Nilsen, S Stefansson, G L Taranger, C J Secombes, H C Morton, S Patel
Pancreas disease (PD) caused by salmonid alphavirus (SAV) is the most serious viral disease in Norwegian aquaculture. Study of the immune response to SAV will aid preventative measures including vaccine development. The innate immune response was studied in Atlantic salmon infected by either bath immersion (BI) or by intra-muscular (i.m.) injection (IM) with SAV subtype 3, two and nine weeks after seawater transfer (Phases A and B respectively). Phase A results have been previously published (Moore et al., 2017) and Phase B results are presented here together with a comparison of results achieved in Phase A...
January 15, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29353055/pituitary-adenylate-cyclase-activating-polypeptide-pacap-signaling-in-the-prefrontal-cortex-modulates-cued-fear-learning-but-not-spatial-working-memory-in-female-rats
#11
Adam J Kirry, Matthew R Herbst, Sarah E Poirier, Michelle M Maskeri, Amy C Rothwell, Robert C Twining, Marieke R Gilmartin
A genetic polymorphism within the gene encoding the pituitary adenylate-cyclase activating polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper-reactivity to threat-related cues in women, but not men, with post-traumatic stress disorder (PTSD). PACAP is a highly conserved peptide, whose role in mediating adaptive physiological stress responses is well established. Far less is understood about the contribution of PACAP signaling in emotional learning and memory, particularly the encoding of fear to discrete cues...
January 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29353053/conditional-inactivation-of-npy1r-gene-in-mice-induces-behavioural-inflexibility-and-orbitofrontal-cortex-hyperactivity-that-are-reversed-by-escitalopram
#12
Angela Longo, Melissa Fadda, Claudio Brasso, Paolo Mele, Paola Palanza, Ishira Nanavaty, Ilaria Bertocchi, Alessandra Oberto, Carola Eva
Cognitive flexibility is the ability to rapidly adapt established patterns of behaviour in the face of changing circumstance and depends critically on the orbitofrontal cortex (OFC). Impaired flexibility also results from altered serotonin transmission in the OFC. The Y1 (Y1R) and Y5 (Y5R) receptors for neuropeptide Y (NPY) colocalize in several brain regions and have overlapping functions in regulating cognition and emotional behaviour. The targeted disruption of gene encoding Y1R (Npy1r gene) in Y5R containing neurons (Npy1rY5R-/- mice) increases anxiety-like behaviour and spatial reference memory...
January 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29353021/phosphoproteomics-unveils-stable-energy-supply-as-key-to-flooding-tolerance-in-kandelia-candel
#13
Dezhuo Pan, Lingxia Wang, Fanglin Tan, Si Lu, Xiaojie Lv, Madiha Zaynab, Chi-Lien Cheng, Yakubu Saddeeq Abubakar, Shipin Chen, Wei Chen
The mangrove Kandelia candel (L.) Druce experiences daily flooding cycles. To explore the molecular mechanism underlying the physiological adaptation of K. candel to flooding, the potential role of protein phosphorylation in flooding responses was investigated by a large-scale quantitative phosphoproteomic analysis using isobaric tag for relative and absolute quantitation. Total 2141 unique phosphopeptides and 2603 non-redundant phosphorylation sites were identified from 1516 phosphoproteins in K. candel leaves...
January 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29352857/combining-chemotherapy-with-pd-1-blockade-in-nsclc
#14
REVIEW
Matthen Mathew, Thomas Enzler, Catherine A Shu, Naiyer A Rizvi
Antitumor immunity relies on the ability of the immune system to recognize tumor cells as foreign and eliminate them. An effective immune response in this setting is due to surveillance of tumor-specific antigens that induce an adaptive immune response resulting in T-cell mediated cytotoxicity. Immune checkpoint inhibitors, specifically those targeting the programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) axis, have demonstrated promising activity in non-small cell lung cancer (NSCLC). However, there remains a crucial need for better treatment strategies for the majority of patients with advanced NSCLC, particularly in the frontline setting...
January 17, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29352783/addressing-global-uncertainty-and-sensitivity-in-first-principles-based-microkinetic-models-by-an-adaptive-sparse-grid-approach
#15
Sandra Döpking, Craig P Plaisance, Daniel Strobusch, Karsten Reuter, Christoph Scheurer, Sebastian Matera
In the last decade, first-principles-based microkinetic modeling has been developed into an important tool for a mechanistic understanding of heterogeneous catalysis. A commonly known, but hitherto barely analyzed issue in this kind of modeling is the presence of sizable errors from the use of approximate Density Functional Theory (DFT). We here address the propagation of these errors to the catalytic turnover frequency (TOF) by global sensitivity and uncertainty analysis. Both analyses require the numerical quadrature of high-dimensional integrals...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352754/providing-ethical-healthcare-in-resource-poor-environments
#16
Kenneth V Iserson
The ethics of providing health care in resource-poor environments is a complex topic. It implies two related questions: What can we do with the resources on hand? Of all the things we can do, which ones should we do? "Resource-poor" (i.e., resource-challenged, resource-constrained) environments are situations in which clinicians, organizations, or healthcare systems have the knowledge and skills, but not the means, to carry out highly effective and beneficial interventions. Determinants of a population's health often rely less on disease and injury management than on recognizing and meeting their basic needs...
January 19, 2018: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/29352745/negative-supercoiling-of-dna-by-gyrase-is-inhibited-in-salmonella-enterica-serovar-typhimurium-during-adaptation-to-acid-stress
#17
Aoife M Colgan, Heather J Quinn, Stefani C Kary, Lesley A Mitchenall, Anthony Maxwell, Andrew Ds Cameron, Charles J Dorman
DNA in intracellular Salmonella enterica serovar Typhimurium relaxes during growth in the acidified (pH 4 to 5) macrophage vacuole and DNA relaxation correlates with upregulation of Salmonella genes involved in adaptation to the macrophage environment. Bacterial ATP levels did not increase during adaptation to acid pH unless the bacterium was deficient in MgtC, a cytoplasmic-membrane-located inhibitor of proton-driven F1 F0 ATP synthase activity. Inhibiting ATP binding by DNA gyrase and topo IV with novobiocin enhanced the effect of low pH on DNA relaxation...
January 20, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29352728/differential-proteomic-analysis-of-synovial-fluid-from-hip-arthroplasty-patients-with-a-pseudotumor-vs-periprosthetic-osteolysis
#18
Isabelle Catelas, Eric A Lehoux, Zhibin Ning, Daniel Figeys, Stephen J Baskey, Paul E Beaulé
Adverse tissue reactions to metal implants, including pseudotumors, can compromise implant functionality and survivorship. The identification of specific proteins in the synovial fluid (SF) of hip arthroplasty patients with a pseudotumor may lead to a better understanding of the underlying pathomechanisms. The objective of the present study was to compare the protein content of SF from patients with a short-term metal-on-metal hip implant associated with a pseudotumor and patients with a long-term metal-on-polyethylene hip implant associated with periprosthetic osteolysis...
January 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29352721/hyperconnective-and-hypoconnective-cortical-and-subcortical-functional-networks-in-multiple-system-atrophy
#19
Johannes Rosskopf, Martin Gorges, Hans-Peter Müller, Elmar H Pinkhardt, Albert C Ludolph, Jan Kassubek
INTRODUCTION: In multiple system atrophy (MSA), the organization of the functional brain connectivity within cortical and subcortical networks and its clinical correlates remains to be investigated. METHODS: Whole-brain based 'resting-state' fMRI data were obtained from 22 MSA patients (11 MSA-C, 11 MSA-P) and 22 matched healthy controls, together with standardized clinical assessment and video-oculographic recordings (EyeLink®). RESULTS: MSA patients vs...
January 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352708/a-systematic-review-and-discussion-of-symptom-specific-cognitive-behavioural-approaches-to-delusions-and-hallucinations
#20
Tania M Lincoln, Emmanuelle Peters
Studies on cognitive behavioural therapy for psychosis (CBTp) have developed from evaluating generic approaches to focusing on specific symptoms. The evidence for targeted studies on delusions and hallucinations was reviewed. We included randomized controlled trials (RCTs) examining the effect of individualized CBT-based interventions focusing either on delusions or on hallucinations. Twelve suitable RCTs were identified. Four RCTs focused on delusions, of which three took a focused approach targeting mechanisms assumed causal to persecutory delusions...
January 16, 2018: Schizophrenia Research
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