keyword
MENU ▼
Read by QxMD icon Read
search

Phosphodiesterase 4

keyword
https://www.readbyqxmd.com/read/29783211/-the-association-between-enpp1-rs997509-polymorphism-and-type-2-diabetes-mellitus-development-in-ukrainian-population
#1
Irina V Marchenko, Yevhen I Dubovyk, Gennadii F Tkach, Olena S Maksymova, Olha I Matlai, Alexander V Ataman, Viktoriia Yu Harbuzova
OBJECTIVE: Introduction: Genome-Wide Association Studies have identified a large number of polymorphic loci associated with type 2 diabetes mellitus (T2DM). Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) gene is one of the candidate genes which have primary importance in T2DM development. Several studies revealed the association between ENPP1 polymorphisms, including rs997509, and T2DM, obesity, insulin resistance and metabolic syndrome in different populations. The aim: To test the association between ENPP1 rs997509 polymorphism and T2DM development in patients with different risk factors in the Ukrainian population...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783161/candidate-gene-analysis-in-the-s%C3%A3-o-paulo-epidemiologic-sleep-study-episono-shows-an-association-of-variant-in-pde4d-and-sleepiness
#2
Victoria M Pak, Diego R Mazzotti, Brendan T Keenan, Camila Hirotsu, Philip Gehrman, Lia Bittencourt, Allan I Pack, Sergio Tufik
INTRODUCTION: Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single-nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory, and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA), and Phosphodiesterase 4D (PDE4D)...
January 12, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29778625/the-mediating-role-of-phosphodiesterase-type-4-in-the-dopaminergic-modulation-of-motor-impulsivity
#3
P R A Heckman, A Blokland, N P Van Goethem, B T J Van Hagen, J Prickaerts
The current study investigated the mediating role of phosphodiesterase type 4 (PDE4) regulated cAMP in the dopaminergic modulation of premature responding (action restraint) in rats. Response inhibition, which includes action restraint, finds its neurobiological origin in cortico-striatal-thalamic circuitry and can be modulated by dopamine. Intracellularly, the effect of dopamine is largely mediated through the cAMP/PKA signaling cascade. Areas in the prefrontal cortex are very sensitive to their neurochemical environment, including catecholamine levels...
May 17, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29777610/phenolic-rich-extracts-of-eurycoma-longifolia-and-cylicodiscus-gabunensis-inhibit-enzymes-responsible-for-the-development-of-erectile-dysfunction-and-are-antioxidants
#4
Ganiyu Oboh, Adeniyi A Adebayo, Ayokunle O Ademosun
BACKGROUND: Herbs have been used from ages to manage male sexual dysfunction. Hence, this study sought to investigate the effects of Eurycoma longifolia (EL) and Cylicodiscus gabunensis (CG) stem bark extracts on some enzymes implicated in erectile dysfunction in vitro. METHODS: The extracts were prepared, and their effects on phosphodiesterase-5 (PDE-5), arginase, and angiotensin-1-converting enzyme (ACE) as well as pro-oxidant-induced lipid peroxidation were assessed...
May 19, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29775418/prolonged-activation-of-camp-signaling-leads-to-endothelial-barrier-disruption-via-transcriptional-repression-of-rras
#5
Carole Y Perrot, Junko Sawada, Masanobu Komatsu
The increase in cAMP levels in endothelial cells triggers cellular signaling to alter vascular permeability. It is generally considered that cAMP signaling stabilizes the endothelial barrier function and reduces permeability. However, previous studies have only examined the permeability shortly after cAMP elevation and thus have only investigated acute responses. Because cAMP is a key regulator of gene expression, elevated cAMP may have a delayed but profound impact on the endothelial permeability by altering the expression of the genes that are vital for the vessel wall stability...
May 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29773452/beneficial-effects-of-rolipram-a-phosphodiesterase-4-specific-inhibitor-on-testicular-torsion-detorsion-injury-in-rats
#6
Deniz Abat, Yıldırım Bayazıt, Arbil Açıkalın, Kenan Dağlıoğlu, Ebru Dündar Yenilmez, Adem Altunkol, Şeyda Erdoğan, Abdullah Tuli
INTRODUCTION: The aim of the study is to investigate the effect of Rolipram, a selective phosphodiesterase 4 inhibitor, on testicular torsion - detorsion injury. METHODS: Sixty young male rats were divided into five groups. In each group, the right testes of six rats were removed four hours after detorsion for biochemical analysis, and the right testes of the remaining six rats were removed 24 h after detorsion for pathological analysis. In group 1 (sham-operated) right orchiectomy was performed without torsion, and right testes were sent to the laboratory for biochemical and pathologic analyses...
April 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29761313/genomewide-dna-methylation-responses-in-patients-with-%C3%AE-thalassemia-treated-with-yisui-shengxue-granules
#7
Yan-Ling Cheng, Xin-Hua Zhang, Yu-Wen Sun, Wen-Juan Wang, Jie Huang, Na-Li Chu, Su-Ping Fang, Zhi-Kui Wu
OBJECTIVE: To examine the clinical effects of Yisui Shengxue Granules () in the treatment of β-thalassemia and explore its mechanism on DNA methylation levels. METHODS: A randomized placebo-controlled double-blinded trial was conducted. Forty patients with β-thalassemia were recruited and distributed randomly by envelope method into an experimental group and a control group, 20 patients in each group. The patients were given Yisui Shengxue Granules in the experimental group and placebo in the control group (12 g/bag three times a day) during a 3-month intervention...
May 3, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752424/placenta-dna-methylation-adaptation-to-maternal-glycemic-response-in-pregnancy
#8
Andres Cardenas, Valerie Gagné-Ouellet, Catherine Allard, Diane Brisson, Patrice Perron, Luigi Bouchard, Marie-France Hivert
Maternal hyperglycemia during pregnancy is associated with excess fetal growth and adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may underlie these associations. We performed an epigenome-wide association study (>850,000 CpG sites) of term placentas and prenatal maternal glycemic response 2-hour post oral glucose challenge at 24-30 weeks of gestation among 448 mother-infant pairs. Maternal 2-hour glycemia post-load was strongly associated with lower DNA methylation of 4 CpGs (FDR q<0...
May 11, 2018: Diabetes
https://www.readbyqxmd.com/read/29740315/compartmentalized-camp-signaling-associated-with-lipid-raft-and-non-raft-membrane-domains-in-adult-ventricular-myocytes
#9
Shailesh R Agarwal, Jackson Gratwohl, Mia Cozad, Pei-Chi Yang, Colleen E Clancy, Robert D Harvey
Aim: Confining cAMP production to discrete subcellular locations makes it possible for this ubiquitous second messenger to elicit unique functional responses. Yet, factors that determine how and where the production of this diffusible signaling molecule occurs are incompletely understood. The fluid mosaic model originally proposed that signal transduction occurs through random interactions between proteins diffusing freely throughout the plasma membrane. However, it is now known that the movement of membrane proteins is restricted, suggesting that the plasma membrane is segregated into distinct microdomains where different signaling proteins can be concentrated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29738700/g-%C3%AE-i-and-g-%C3%AE-%C3%AE-subunits-have-opposing-effects-on-dexmedetomidine-induced-sedation
#10
Meng Liu, Yi Yang, Bo Tan, Yulei Li, Peilan Zhou, Ruibin Su
Dexmedetomidine (DMED) is a potent and highly selective α2 -adrenergic receptor agonist and is widely used for short-term sedation. However, the mechanism of DMED-induced sedation has not been deciphered. In the present study, we investigated the mechanism of Gαi and Gβγ subunits on DMED-induced sedation. An ED50 of DMED-induced loss of righting reflex (200.0nmol/kg) was increased to 375.0 or 433.3nmol/kg after pre-treatment with cAMP analog dbcAMP (50nmol/5μl/mouse, i.c.v.) or the phosphodiesterase 4 inhibitor rolipram (100nmol/5μl/mouse, i...
May 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29737914/lipidomics-reveal-aryl-hydrocarbon-receptor-ahr-regulated-lipid-metabolic-pathway-in-alpha-naphthyl-isothiocyanate-anit-induced-intrahepatic-cholestasis
#11
Bao-Long Wang, Chang-Wen Zhang, Liang Wang, Kun-Long Tang, Naoki Tanaka, Frank J Gonzalez, Yong Xu, Zhong-Ze Fang
1. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOF MS)-based lipidomics was employ to elucidate new mechanism of alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in mice. 2. Multiple lipid components significantly increased in ANIT-induced intrahepatic cholestasis, including PC 16:0, 20:4, PC 16:0, 22:6, PC 16:0, 18:2, LPC 18:2, PC 18:2, LPC 18:1, PC 18:1, 14:0, SM 18:1, 16:0, oleoylcarnitine, and palmitoylcarnitine...
May 8, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29730885/adverse-events-associated-with-apremilast-use-and-withdrawal-for-psoriasis-in-a-real-world-setting
#12
Erica B Lee, Mina Amin, Alexander Egeberg, Jashin J Wu
Apremilast, a phosphodiesterase-4 inhibitor, is an oral therapy for treatment of psoriasis. Its safety profile is favorable, with side effects including diarrhea, nausea, vomiting, depression, and weight decrease, primarily based on clinical trial data. However, limited research exists on the side effect frequency and subsequent adverse events (AEs) in real-world practice. This retrospective chart review included patients who presented to the dermatology clinic at Kaiser Permanente Los Angeles Medical Center and were treated with apremilast at any time between January 1, 2015 and January 11, 2018...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29729992/proteomics-functional-characterization-and-antivenom-neutralization-of-the-venom-of-pakistani-russell-s-viper-daboia-russelii-from-the-wild
#13
Tasnim Faisal, Kae Yi Tan, Si Mui Sim, Naeem Quraishi, Nget Hong Tan, Choo Hock Tan
The venom proteome of wild Pakistani Russell's viper (Daboia russelii) was investigated through nano-ESI-LCMS/MS of the reverse-phase HPLC fractions. A total of 54 venom proteins were identified and clustered into 11 protein families. Phospholipase A2 (PLA2 , 63.8%) and Kunitz-type serine protease inhibitor (KSPI, 16.0%) were most abundant, followed by snake venom serine protease (SVSP, 5.5%, mainly Factor V activating enzyme), vascular endothelial growth factor (VEGF, 4.3%), snake venom metalloprotease (SVMP, 2...
May 3, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29729370/reduced-protein-expression-of-the-phosphodiesterases-pde4a4-and-pde4a8-in-aip-mutation-positive-somatotroph-adenomas
#14
Mariana Ferreira Bizzi, Sergio Veloso Brant Pinheiro, Graeme B Bolger, Junia Ribeiro de Oliveira Longo Schweizer, Alexandre V Giannetti, Mary N Dang, Antonio Ribeiro-Oliveira, Márta Korbonits
Type 4 phosphodiesterases (PDE4s) of the large PDE enzyme superfamily have unique specificity for cAMP and may, therefore, be relevant for somatotroph tumorigenesis. Somatotroph adenomas typically overexpress PDEs probably as part of a compensatory mechanism to reduce cAMP levels. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein, coded by a tumour suppressor gene mutated in a subgroup of familial isolated pituitary adenomas (FIPAs). PDE4A8 is the closest related isoform of PDE4A4...
May 3, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29727210/benzoxaborole-compounds-for-therapeutic-uses-a-patent-review-2010-2018
#15
Alessio Nocentini, Claudiu T Supuran, Jean-Yves Winum
Benzoxaborole is a versatile boron-heterocyclic scaffold which has found in the last 10 years a broad spectrum of applications in medicinal chemistry, due to its physicochemical and drug-like properties. Use of benzoxaborole moiety in the design of compounds led to the discovery of new classes of anti-bacterial, anti-fungal, anti-protozoal, anti-viral as well as anti-inflammatory agents with interesting drug development perspectives. Areas covered: This article reviews the patent literature as well as chemistry literature during the period 2010-2018 where in several benzoxaborole derivatives with therapeutic options were reported...
May 4, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29726052/enantioselective-non-covalent-substrate-directable-heck-matsuda-and-oxidative-heck-arylations-of-unactivated-five-membered-carbocyclic-olefins
#16
Carlos Duarte Correia, Juliana Oliveira, Ricardo Almir Angnes, Ismat Ullah Khan, Ellen Christine Polo, Gabriel Heerdt, Bruno Servilha, Vitor Silva, Ataualpa Braga
Highly diastereo and enantioselective non-covalent substrate directable Heck desymmetrizations of cyclopentenyl olefins bearing hydroxymethyl and carboxylate functional groups are presented. These conformationally unbiased cyclic olefins underwent effective arylations in yields of up to 97%, diastereoselectivity up to >20:1, and enantiomeric excesses of up to 99%. Non-covalent directing effects were shown to be present in Heck-Matsuda and oxidative Heck reactions allowing the preferential formation of cis-substituted aryl cyclopentenes containing two stereocenters, including quaternary stereocenters...
May 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29724533/targeting-phosphodiesterase-5-by-vardenafil-improves-vascular-graft-function
#17
Gábor Veres, Martin Hagenhoff, Harald Schmidt, Tamás Radovits, Sivakkanan Loganathan, Yang Bai, Sevil Korkmaz-Icöz, Paige Brlecic, Alex Ali Sayour, Matthias Karck, Gábor Szabó
OBJECTIVES: Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide-cGMP pathway in the vessel wall of the bypass graft was investigated...
May 1, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29716881/mini-review-chronic-obstructive-pulmonary-disease-its-new-drug-treatments-and-strategies-a-review
#18
Muhammad Hanif, Junaid Qureshi, Hira Ijaz, Muhammad Iqbal Mustafa, Akhtar Rasul, Naeem Amir, Basma Aftab, Ahad Fayyaz
COPD is a complicated disease. Current available treatments are just for symptomatic relief and they cannot reverse the damages to lungs tissues due to alveolar destruction in COPD. Research is being conducted to evaluate new treatments and strategies to find specific treatments to minimize the symptoms of COPD. A new mixture of herbal medicine i.e AKL1 has emerged and thought to cure COPD symptoms especially cough related quality of life of COPD patients. Although, the results have showed no significant difference as compared to placebo but researchers recommend further evaluation in a large population (COPD Patients) group...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29713919/phosphodiesterase-4-and-7-inhibitors-produce-protective-effects-against-high-glucose-induced-neurotoxicity-in-pc12-cells-via-modulation-of-the-oxidative-stress-apoptosis-and-inflammation-pathways
#19
Nazanin Namazi Sarvestani, Saeedeh Saberi Firouzi, Reza Falak, Mohammad Yahya Karimi, Mohammad Davoodzadeh Gholami, Akram Rangbar, Asieh Hosseini
Diabetic neuropathy (DN) is the most common diabetic complication. It is estimated diabetic population will increase to 592 million by the year 2035. This is while at least 50-60% of all diabetic patients will suffer from neuropathy in their lifetime. Oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation are crucial pathways in development and progression of DN. Since there is also no selective and effective therapeutic agent to prevent or treat high glucose (HG)-induced neuronal cell injury, it is crucial to explore tools by which one can reduce factors related to these pathways...
April 30, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29710495/phosphodiesterase-4-inhibition-confers-a-neuroprotective-efficacy-against-early-brain-injury-following-experimental-subarachnoid-hemorrhage-in-rats-by-attenuating-neuronal-apoptosis-through-the-sirt1-akt-pathway
#20
Qun Li, Yucong Peng, Linfeng Fan, Hangzhe Xu, Pingyou He, Shenglong Cao, Jianru Li, Ting Chen, Wu Ruan, Gao Chen
Phosphodiesterase-4 (PDE4) plays a fundamental role in a range of central nervous system (CNS) insults, however, the role of PDE4 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains unclear. The current study was designed to investigate the role of PDE4 in EBI after SAH and explore the potential mechanism. The SAH model in Sprague-Dawley rat was established by endovascular perforation process. Rats were randomly divided into: sham group, SAH?+?vehicle group, SAH?+?rolipram (PDE4 inhibitor) group, SAH?+?rolipram?+?sirtinol (SIRT1 inhibitor) group and SAH?+?rolipram+MK2206 (Akt inhibitor) group...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
29573
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"