Kelly Allott, Hok Pan Yuen, Lara Baldwin, Brian O'Donoghue, Alex Fornito, Sidhant Chopra, Barnaby Nelson, Jessica Graham, Melissa J Kerr, Tina-Marie Proffitt, Aswin Ratheesh, Mario Alvarez-Jimenez, Susy Harrigan, Ellie Brown, Andrew D Thompson, Christos Pantelis, Michael Berk, Patrick D McGorry, Shona M Francey, Stephen J Wood
The drivers of cognitive change following first-episode psychosis remain poorly understood. Evidence regarding the role of antipsychotic medication is primarily based on naturalistic studies or clinical trials without a placebo arm, making it difficult to disentangle illness from medication effects. A secondary analysis of a randomised, triple-blind, placebo-controlled trial, where antipsychotic-naive patients with first-episode psychotic disorder were allocated to receive risperidone/paliperidone or matched placebo plus intensive psychosocial therapy for 6 months was conducted...
June 10, 2023: Translational Psychiatry