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https://www.readbyqxmd.com/read/29771835/the-arterialized-facial-artery-musculo-mucosal-island-flap-for-post-oncological-tongue-reconstruction
#1
Alessandro Moro, Gianmarco Saponaro, Piero Doneddu, Daniele Cervelli, Sandro Pelo, Giulio Gasparini, Umberto Garagiola, Giuseppe D'Amato, Mattia Todaro
BACKGROUND: In 1992, Pribaz described the facial artery musculomucosal flap (FAMM), an axial musculomucosal flap based on the facial artery. The FAMM flap, a modification of the nasolabial and buccal mucosal flaps, is widely used in the reconstruction of defects in the oral cavity. Many modifications of this flap have been described in the literature. Here we aimed to explore the use of an arterialized tunnelized FAMM island flap (a-FAMMIF) for the reconstruction tongue defects after tumor resection...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#2
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29765235/fatal-hemoptysis-in-patients-with-advanced-esophageal-cancer-treated-with-apatinib
#3
Wei Wang, Lin Zhang, Yan Xie, Tianchang Zhen, Gongzhang Su, Qi Zang
Targeted therapy is commonly used for treating advanced malignant tumors. Compared with cytotoxic drugs, targeted drugs have the characteristics of good curative results, less adverse effects, and convenient oral administration. Hence, they are especially suitable for patients with cancer who are not able to tolerate chemotherapy. Anti-angiogenic therapy can achieve the objective by inhibiting the formation of new blood vessels in tumors. Apatinib is a novel tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor-2...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29761586/preoperative-predictors-of-occult-nodal-disease-in-ct1n0-oral-cavity-squamous-cell-carcinoma-review-of-2623-cases
#4
Kevin Y Zhan, Patrick F Morgan, David M Neskey, Joanne J Kim, Andrew T Huang, Elizabeth Garrett-Mayer, Terry A Day
BACKGROUND: Nodal disease predicts survival in oral cavity squamous cell carcinoma (SCC). Currently, no large studies on predictors of occult nodal disease in cT1N0 oral cavity SCC exist. METHODS: The National Cancer Database (NCDB) review for cT1N0 oral cavity SCC with surgical resection and elective neck dissection (END). RESULTS: The number of patients found with occult nodal disease was 2623 (15.1%). In multivariable regression, female sex and tumor differentiation predict occult nodal disease...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761306/low-expression-of-cd40l-in-tumor-free-lymph-node-of-oral-cavity-cancer-related-with-poor-prognosis
#5
Yoon Chan Rah, Jae-Cheul Ahn, Eun-Hui Jeon, Hyojin Kim, Jin Ho Paik, Woo-Jin Jeong, Soon-Young Kwon, Soon-Hyun Ahn
BACKGROUND: Recently, the genetic alterations associated with tumor progression and impaired host immunity against transformed cells draw increased attention. Here, we characterized the differential gene expression patterns and protein expression in tumor-free lymph node from recurrent and non-recurrent tumors to identify independent prognostic markers for oral squamous cell carcinoma (OSCC). METHODS: A cDNA microarray analysis was performed to identify the differentially expressed genes in regional tumor-free lymph nodes from OSCC patients with and without recurrence...
May 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29760804/association-between-fusobacterium-nucleatum-and-colorectal-cancer-progress-and-future-directions
#6
REVIEW
Sheng Zhang, Sanjun Cai, Yanlei Ma
The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commensal anaerobe in the oral cavity, has been associated with CRC. Several research teams have reported an overabundance of Fn in human CRC and have elucidated the possible mechanisms by which Fn is involved in colorectal carcinogenesis in vitro and in mouse models...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29757457/the-role-of-adjuvant-treatment-in-early-stage-oral-cavity-squamous-cell-carcinoma-an-international-collaborative-study
#7
Eran Fridman, Shorook Na'ara, Jaiprakash Agarwal, Moran Amit, Gideon Bachar, Andrea Bolzoni Villaret, Jose Brandao, Claudio R Cernea, Pankaj Chaturvedi, Jonathan Clark, Ardalan Ebrahimi, Dan M Fliss, Sashikanth Jonnalagadda, Hugo F Kohler, Luiz P Kowalski, Matthias Kreppel, Chun-Ta Liao, Snehal G Patel, Raj P Patel, K Thomas Robbins, Jatin P Shah, Thomas Shpitzer, Tzu-Chen Yen, Joachim E Zöller, Ziv Gil
BACKGROUND: Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC. METHODS: Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis...
May 14, 2018: Cancer
https://www.readbyqxmd.com/read/29756393/opioid-prescribing-practices-in-patients-undergoing-surgery-for-oral-cavity-cancer
#8
John Pang, Kathryn R Tringale, Viridiana J Tapia, Bharat A Panuganti, Jesse R Qualliotine, Aria Jafari, Sunny J Haft, Lawrence S Friedman, Timothy Furnish, Kevin T Brumund, Joseph A Califano, Charles S Coffey
OBJECTIVES: Opioids have been overprescribed after general and orthopedic surgeries, but prescribing patterns have not been reported for head and neck surgery. The objectives of this retrospective review are to describe postoperative opioid prescriptions after oral cancer surgery and determine which patients receive higher amounts. METHODS: A single institution retrospective review was performed for 81 adults with oral cavity tumors undergoing surgery. Opioid prescriptions upon discharge were reported in daily oral morphine equivalents (OME)...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29756389/pretreatment-risk-stratification-of-feeding-tube-use-in-patients-treated-with-intensity-modulated-radiotherapy-for-head-and-neck-cancer
#9
Nigel J Anderson, James E Jackson, Jennifer G Smith, Morikatsu Wada, Michal Schneider, Michael Poulsen, Maureen Rolfo, Maziar Fahandej, Hui Gan, Daryl Lim Joon, Vincent Khoo
BACKGROUND: The purpose of this study was to establish a risk stratification model for feeding tube use in patients who undergo intensity-modulated radiotherapy (IMRT) for head and neck cancers. METHODS: One hundred thirty-nine patients treated with definitive IMRT (+/- concurrent chemotherapy) for head and neck mucosal cancers were included in this study. Patients were recommended a prophylactic feeding tube and followed up by a dietician for at least 8 weeks postradiotherapy (post-RT)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29755685/selected-pet-radiomic-features-remain-the-same
#10
Tetsuya Tsujikawa, Hideaki Tsuyoshi, Masafumi Kanno, Shizuka Yamada, Masato Kobayashi, Norihiko Narita, Hirohiko Kimura, Shigeharu Fujieda, Yoshio Yoshida, Hidehiko Okazawa
Purpose: We investigated whether PET radiomic features are affected by differences in the scanner, scan protocol, and lesion location using 18 F-FDG PET/CT and PET/MR scans. Results: SUV, TMR, skewness, kurtosis, entropy, and homogeneity strongly correlated between PET/CT and PET/MR images. SUVs were significantly higher on PET/MR0-2 min and PET/MR0-10 min than on PET/CT in gynecological cancer ( p = 0.008 and 0.008, respectively), whereas no significant difference was observed between PET/CT, PET/MR0-2 min , and PET/MR0-10 min images in oral cavity/oropharyngeal cancer...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755677/sex-specific-differences-in-the-occurrence-of-fusobacterium-nucleatum-subspecies-and-fusobacterium-periodonticum-in-the-oral-cavity
#11
Karsten Henne, Hildegard Schilling, Mark Stoneking, Georg Conrads, Hans-Peter Horz
The periodontitis-associated species Fusobacterium nucleatum (FN) has been implicated in several extra-oral diseases, including preterm birth and colorectal cancer. Due to its genetic and phenotypic heterogeneity, FN is classified in four subspecies which may differ in their disease potential. Here we compared the prevalence of FN subspecies and the close relative F. periodonticum (FP) via 16S rRNA gene analysis in saliva from 100 healthy individuals (60 females, and 40 males) from eleven countries spanning five continents...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29753688/citrus-fruits-intake-and-oral-cancer-risk-a-systematic-review-and-meta-analysis
#12
REVIEW
Santa Cirmi, Michele Navarra, Jayne V Woodside, Marie M Cantwell
OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm. STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
May 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29752322/nccn-guidelines-insights-head-and-neck-cancers-version-1-2018
#13
A Dimitrios Colevas, Sue S Yom, David G Pfister, Sharon Spencer, David Adelstein, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Maura L Gillison, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the H&N, and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding evaluation and treatment of nasopharyngeal carcinoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29751076/tobacco-specific-nitrosamines-a-literature-review
#14
Evangelia Konstantinou, Foteini Fotopoulou, Athanasios Drosos, Nektaria Dimakopoulou, Zoi Zagoriti, Athanasios Niarchos, Dimitra Makrynioti, Dimitrios Kouretas, George Lagoumintzis, Konstantinos Poulas
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period, while a number are produced when a cigarette is burned. Considerable evidence supports the role of TSNA important causative factors for cancers of the lung, pancreas, esophagus, and oral cavity in people who use tobacco products. Of the known TSNA, nicotine-derived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN) are the most carcinogenic...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29750853/depth-of-invasion-on-pathological-outcomes-in-clinical-low-stage-oral-tongue-cancer-patients
#15
Maheer M Masood, Douglas R Farquhar, Jessica P Vanleer, Samip N Patel, Trevor G Hackman
OBJECTIVES: Depth of invasion was added to the 8th edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim is to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. SUBJECTS AND METHODS: All clinical T1/T2 N0 HPV negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29750234/knowledge-of-oral-cancer-among-the-community-served-during-the-stomatological-lesion-prevention-campaign-conducted-at-universidad-cat%C3%A3-lica-de-santiago-de-guayaquil-ecuador
#16
Karla Cruz-Moreira, Fuad Huamán-Garaicoa, Gabriela Mena
The aim of this study was to evaluate the level of knowledge on oral cancer and level of preventive care among the population. A descriptive cross-sectional study was performed to evaluate 408 individuals through a face-to-face survey at Universidad Católica de Santiago de Guayaquil during the 2016 academic year. Sixty-one percent (61%) of respondents said they knew of the existence of oral cancer, but 56.1% did not know that 'white spots' in the oral cavity could become malignant, and 50.7% did not know that 'lumps'could be oral cancer...
December 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/29749745/potential-cytotoxic-and-selective-effect-of-new-benzo-b-xanthenes-against-oral-squamous-cell-carcinoma
#17
Bruna C Zorzanelli, Lucas N de Queiroz, Raíssa Ma Santos, Luiza M Menezes, Fernanda C Gomes, Vitor F Ferreira, Fernando de C da Silva, Bruno K Robbs
AIM: The current work shows a new synthetic methodology to obtain 21 naphthoquinones that have been evaluated against oral cavity cancer. The compounds were obtained by a three-component reaction involving lawsone, dimedone and aromatic aldehydes catalyzed by lithium chloride under microwave irradiation to produce families of 1,4- and 1,2-naphthoquinones. RESULTS: A clonogenic assay was performed on SCC9 cell line cultures with all compounds, revealing five very active compounds...
May 11, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29742291/pd-1-and-pd-l1-expression-in-hnscc-primary-cancer-and-related-lymph-node-metastasis-impact-on-clinical-outcome
#18
Sven Schneider, Lorenz Kadletz, Robert Wiebringhaus, Lukas Kenner, Edgar Selzer, Thorsten Füreder, Orsolya Rajky, Anna S Berghoff, Matthias Preusser, Gregor Heiduschka
AIMS: Expression profiles and clinical impact of programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not fully elucidated. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and impact on patients' clinical outcome. METHODS AND RESULTS: Immunohistochemical staining patterns of PD-L1 and PD-1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases...
May 9, 2018: Histopathology
https://www.readbyqxmd.com/read/29740925/metformin-directly-targets-the-h3k27me3-demethylase-kdm6a-utx
#19
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Pares, Salvador Fernández-Arroyo, Fedra Luciano-Mateo, Noemí Cabré, Jan Stursa, Lukas Werner, Begoña Martin-Castillo, Benoit Viollet, Jiri Neuzil, Jorge Joven, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Javier A Menendez
Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for decades in the absence of a complete understanding of its therapeutic targets or chemical determinants. We here outline a systematic chemoinformatics approach to computationally predict biomolecular targets of metformin. Using several structure- and ligand-based software tools and reference databases containing 1,300,000 chemical compounds and more than 9,000 binding sites protein cavities, we identified 41 putative metformin targets including several epigenetic modifiers such as the member of the H3K27me3-specific demethylase subfamily, KDM6A/UTX...
May 8, 2018: Aging Cell
https://www.readbyqxmd.com/read/29740440/targeting-head-and-neck-cancer-by-vaccination
#20
REVIEW
Chuan Wang, James Dickie, Ruhcha V Sutavani, Catherine Pointer, Gareth J Thomas, Natalia Savelyeva
Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC...
2018: Frontiers in Immunology
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