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Silvia Rodriguez-Blanco, Ignacio Oulego-Erroz, Sandra Gautreaux-Minaya, Alejandro Perez-Muñuzuri, Maria Luz Couce-Pico
OBJECTIVE: To assess whether early NT-ProBNP can identify the need for echocardiographic assessment of hemodynamically significant patent ductus arteriosus (HsPDA) in preterm infants. STUDY DESIGN: Prospective observational study of infants with a gestational age ≤32 weeks. Echocardiographic assessment and NT-proBNP measurement were performed at 48-96 h. ROC curves were generated to assess optimal cutoffs to detect HsPDA and predict the need for treatment. RESULTS: Eighty-five patients were included...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Daniel Tritz, Kody Dormire, Travis Brachtenbach, Joshua Gordon, Donald Sanders, David Gearheart, Julia Crawford, Matt Vassar
INTRODUCTION: Wilderness medicine involves the treatment of individuals in remote, austere environments. Given the high potential for injuries as well as the unique treatment modalities required in wilderness medicine, evidence-based clinical practice guidelines are necessary to provide optimal care. In this study, we identify evidence gaps from low-quality recommendations in wilderness medicine clinical practice guidelines and identify new/ongoing research addressing them. METHODS: We included relevant clinical practice guidelines from the Wilderness Medical Society and obtained all 1C or 2C level recommendations...
May 18, 2018: Wilderness & Environmental Medicine
Smith Jennifer, Birinder Praneet Purewal, Alison Macpherson, Ian Pike
INTRODUCTION: Despite legal protections for young workers in Canada, youth aged 15-24 are at high risk of traumatic occupational injury. While many injury prevention initiatives targeting young workers exist, the challenge faced by youth advocates and employers is deciding what aspect(s) of prevention will be the most effective focus for their efforts. A review of the academic and grey literatures was undertaken to compile the metrics-both the indicators being evaluated and the methods of measurement-commonly used to assess injury prevention programs for young workers...
May 2018: Health Promotion and Chronic Disease Prevention in Canada
Maryam Jalali, Andrew R White, James Marti, Jian Sheng
Texturing a large surface with oily micro-drops with controlled size, shape and volume provides an unprecedented capability in investigating complex interactions of bacteria, cells and interfaces. It has particular implications in understanding key microbial processes involved in remediation of environmental disasters, such as Deepwater Horizon oil spill. This work presents a development of scalable micro-transfer molding to functionalize a substrate with oily drop array to generate a microcosm mimicking bacteria encountering a rising droplet cloud...
May 15, 2018: Scientific Reports
Enrique Angulo Picó, Carmen López, Álvaro Cruz-Izquierdo, Mercedes Munarriz, Francisco Javier Iruretagoyena, Juan Luis Serra, María Jesús Llama
In this work, magnetic cross-linked enzyme aggregates (mCLEAs) of CALB (lipase B from Candida antarctica) were prepared and characterized. Moreover, a method for an easy, sustainable and economic extraction of lipids from nitrogen-starved cells of Chlorella vulgaris var L3 was developed. Then, the extracted lipids (oils and free fatty acids, FFAs) were converted to biodiesel using mCLEAs and chemical acid catalysis. Among several lipid extraction methods, saponification was selected given the amount of wet microalgal biomass it can process per unit of time, its low market value, and because it allows for the use of less toxic solvents...
May 12, 2018: Journal of Bioscience and Bioengineering
Riham Fliefel, Michael Ehrenfeld, Sven Otto
BACKGROUND: It is now well-established that regenerative medicine and stem cell therapy are the most promising approach to obtain full tissue regeneration by using various cell types including stem cells isolated from adult tissues, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Recently, iPSCs have been successfully differentiated into osteoprogenitors to facilitate repair and regeneration of bone defects. Thus, the purpose of this systematic review and meta-analysis is to summarize the articles published that assess the osteogenic potential of iPSCs in-vitro and their ability to heal bone defects in reconstructive surgery...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
I Solak, C D Cetinkaya, Y T Gederet, B Kozanhan, O Erel, M A Eryilmaz
OBJECTIVE: Cigarette smoking is an important risk factor for many diseases. This study aimed to evaluate whether cigarette smoking is associated with changes in the thiol/disulfide homeostasis (TDH), a novel biomarker of systemic oxidative stress. PATIENTS AND METHODS: Eighty-four smokers and 86 non-smoking healthy volunteers were enrolled. Serum native thiol, disulfide and total thiol levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a new colorimetric method...
April 2018: European Review for Medical and Pharmacological Sciences
Riccardo Caricasulo, Luciano Malchiodi, Paolo Ghensi, Giuliano Fantozzi, Alessandro Cucchi
PURPOSE: Different implant-abutment connections are available and it has been claimed they could have an effect on marginal bone loss. The aim of this review is to establish if implant connection configuration influences peri-implant bone loss (PBL) after functional loading. METHODS: A specific question was formulated according to the Population, Intervention, Control, and Outcome (PICO): Does the type of implant-abutment connection (external, internal, or conical) have an influence on peri-implant bone loss? A PubMed/MEDLINE electronic search was conducted to identify English language publications published in international journals during the last decade (from 2006 to 2016)...
May 15, 2018: Clinical Implant Dentistry and related Research
Rafaella S Leão, Sandra L D Moraes, Belmiro C E Vasconcelos, Cleidiel A A Lemos, Eduardo P Pellizzer
Splinted and unsplinted overdenture attachment systems have unique advantages and disadvantages. The aim of the present systematic review was to determine the influence of splinted and unsplinted overdenture attachment systems on the marginal bone loss, prosthetic complications, and implant survival rate. PubMed/MEDLINE, Scopus, and Cochrane databases were searched for articles published up to October 2017, using the following search terms: "overdenture AND attachment OR overdenture AND bar OR overdenture splinted"...
May 15, 2018: Journal of Oral Rehabilitation
Clément Charbonnel, Christophe Jego, François Jourda, Ulric Vinsonneau, Philippe Garçon, Guillaume Turlotte, Jean François Rivière, Marion Maurin, Rémy Lubret, Patrick Meimoun, Chrystelle Akret, Maxime Cournot, Charles Sokic, Laurent Michel, Maryse Lescure, David Kenizou, Marie Melay, Maxime Fayard, Bruno Gallet, Rémi Fouche, Luc Janin-Manificat, Nicolas Dijoux, Anne Céline Martin, Aurélia Tho-Agostini, Hubert Mann, Cécile Ricard, Fernando Pico, Jean Louis Georges, Loïc Belle, Patrick Jourdain
BACKGROUND AND AIM: The clinical utility of transesophageal echocardiography (TEE) after brain ischemia (BI) remains a matter of debate. We aimed to evaluate the clinical impact of TEE and to build a score that could help physicians to identify which patients should better benefit from TEE. METHODS: This prospective, multicenter, observational study included patients over 18 years old, hospitalized for BI. TEE findings were judged discriminant if the results showed important information leading to major changes in the management of patients...
May 14, 2018: Echocardiography
Alexander Drzezga, Daniele Altomare, Cristina Festari, Javier Arbizu, Stefania Orini, Karl Herholz, Peter Nestor, Federica Agosta, Femke Bouwman, Flavio Nobili, Zuzana Walker, Giovanni Battista Frisoni, Marina Boccardi
PURPOSE: To assess the clinical utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of early signs of neurodegeneration in conditions of increased risk for Alzheimer's disease (AD) as defined by: subjective cognitive decline (SCD), evidence of cerebral amyloid-pathology, apolipoprotein E (APOE) ε4-positive genotype, or autosomal dominant forms of AD (ADAD) in asymptomatic stages. METHODS: A comprehensive literature search was conducted using the PICO model to extract evidence from relevant studies...
May 13, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Sudipta Gupta, Judith U De Mel, Rasangi M Perera, Piotr Zolnierczuk, Markus Bleuel, Antonio Faraone, Gerald J Schneider
We investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. We report the first experimental evidence of a short-range motion at the length-scale of the size of the head group of a lipid. The associated mean squared displacement shows a t0.26 dependence in the pico- to nanosecond region that indicates another process beyond the predictions of the Zilman-Granek model (t0.66) and translational diffusion (t1). A comparison with theory shows that the observed low exponent is associated with a non-Gaussian transient trapping of lipid molecules in a local area and supports the continuous time random walk model...
May 12, 2018: Journal of Physical Chemistry Letters
Femke Bouwman, Stefania Orini, Federica Gandolfo, Daniele Altomare, Cristina Festari, Federica Agosta, Javier Arbizu, Alexander Drzezga, Peter Nestor, Flavio Nobili, Zuzana Walker, Silvia Morbelli, Marina Boccardi
PURPOSE: A joint effort of the European Association of Nuclear Medicine (EANM) and the European Academy of Neurology (EAN) aims at clinical guidance for the use of FDG-PET in neurodegenerative diseases. This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment in the differentiation of the three forms of primary progressive aphasia (PPA). METHODS: Seven panelists were appointed by the EANM and EAN and a literature search was performed by using harmonized PICO (Population, Intervention, Comparison, Outcome) question keywords...
May 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Federico Vita, Flavio Antonio Franchina, Cosimo Taiti, Vittoria Locato, Giorgio Pennazza, Marco Santonico, Giorgia Purcaro, Laura De Gara, Stefano Mancuso, Luigi Mondello, Amedeo Alpi
The influences of various factors, including the symbiosis established with the roots of specific tree species, on the production of volatiles in the fruiting bodies of Tuber magnatum have not been investigated yet. Volatiles in T. magnatum fruiting bodies were quantitatively and qualitatively determined by both PTR-MS and GC-MS in order to compare the accuracy of the two methods. An electronic nose was also used to characterize truffle samples. The influence of environmental changes on the antioxidant capabilities of fruiting bodies was also determined...
May 8, 2018: Scientific Reports
Peter J Nestor, Daniele Altomare, Cristina Festari, Alexander Drzezga, Jasmine Rivolta, Zuzana Walker, Femke Bouwman, Stefania Orini, Ian Law, Federica Agosta, Javier Arbizu, Marina Boccardi, Flavio Nobili, Giovanni Battista Frisoni
AIM: To assess the clinical utility of FDG-PET as a diagnostic aid for differentiating Alzheimer's disease (AD; both typical and atypical forms), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), vascular dementia (VaD) and non-degenerative pseudodementia. METHODS: A comprehensive literature search was conducted using the PICO model to extract evidence from relevant studies. An expert panel then voted on six different diagnostic scenarios using the Delphi method...
May 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Maarten A Ligtenberg, Yago Pico de Coaña, Taisia Shmushkovich, Yuya Yoshimoto, Iva Truxova, Yuan Yang, Monica Betancur-Boissel, Alexey V Eliseev, Alexey D Wolfson, Rolf Kiessling
Adoptive cell therapy (ACT) is becoming a prominent alternative therapeutic treatment for cancer patients relapsing on traditional therapies. In parallel, antibodies targeting immune checkpoint molecules, such as cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) and cell death protein 1 pathway (PD-1), are rapidly being approved for multiple cancer types, including as first line therapy for PD-L1-expressing non-small-cell lung cancer. The combination of ACT and checkpoint blockade could substantially boost the efficacy of ACT...
April 13, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Danilo Sciarrone, Antonino Schepis, Mariosimone Zoccali, Paola Donato, Federico Vita, Donato Creti, Amedeo Alpi, Luigi Mondello
Truffles are among the most expensive foods available in the market, usually used as flavouring additives for their distinctive aroma. The most valuable species is Tuber magnatum Pico, better known as "Alba white truffle", in which bis(methylthio)methane is the key aroma compound. Given the high economical value of genuine white truffles, analytical approaches are required, able to discriminate between natural or synthetic truffle aroma. Gas chromatography coupled to combustion-isotope ratio mass spectrometry (GC-C-IRMS), exploiting the 13C/12C ratio abundance of the key flavourings compounds in foods, has been a recognized technique for authenticity and traceability purposes, however a number of issues have greatly limited its widespread use, so far...
May 7, 2018: Analytical Chemistry
E Linares-Espinós, V Hernández, J L Domínguez-Escrig, S Fernández-Pello, V Hevia, J Mayor, B Padilla-Fernández, M J Ribal
CONTEXT: The objective of evidence-based medicine is to employ the best scientific information available to apply to clinical practice. Understanding and interpreting the scientific evidence involves understanding the available levels of evidence, where systematic reviews and meta-analyses of clinical trials are at the top of the levels-of-evidence pyramid. ACQUISITION OF EVIDENCE: The review process should be well developed and planned to reduce biases and eliminate irrelevant and low-quality studies...
May 3, 2018: Actas Urologicas Españolas
Salvador Alcocer, Alain Picos, Agustín R Uribe, Tzayam Pérez, Juan M Peralta-Hernández
Comparative degradation of the industrial dyes Blue BR, Violet SBL and Brown MF 50 mg L-1 has been studied by the electrochemical oxidation (EOx), electro-Fenton (EF), photoelectro-Fenton (PEF) process based on BDD electrode. Each dye was tested in 0.05 mM Na2 SO4 with 0.5 mM Fe2+ at pH 3.0, and electrolyzed in a stirred tank reactor under galvanostatic conditions with 2.0, 5.0, 7.0, 11.0 and 18.0 mA cm-2 . Dyes were oxidized via hydroxyl radicals (OH) formed at the BDD anode from water oxidation coupled with Fenton's reaction cathodically produced hydrogen peroxide (H2 O2 )...
April 27, 2018: Chemosphere
Giovane Hisse Gomes, Mônica Yuri Orita Misawa, Carolina Fernandes, Claudio Mendes Pannuti, Luciana Saraiva, Guy Huynh-Ba, Cristina Cunha Villar
The aim of this study was to conduct a systematic review and meta-analysis to assess the clinical outcomes of dental implants placed in previously early and late implant failed sites. An electronic literature search was conducted in several databases for articles published up to February 2018. Human clinical trials that received at least one implant in a previously failed site were included. Hence, the PICO question that was aimed to be addressed was: Do patients undergoing implant replacement (second and third attempts) in previous failed sites have survival rates similar to implants placed at first attempts? A random effects model was used to calculate survival weighted means and corresponding 95% Confidence Intervals (CI) among studies...
2018: Brazilian Oral Research
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