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https://www.readbyqxmd.com/read/29150682/enantioselective-transformation-of-fluoxetine-in-water-and-its-ecotoxicological-relevance
#1
María Jesús Andrés-Costa, Kathryn Proctor, Marco T Sabatini, Anthony P Gee, Simon E Lewis, Yolanda Pico, Barbara Kasprzyk-Hordern
European legislation focusing on water quality is expected to broaden to encompass several pharmaceuticals as priority hazardous substances. This manuscript aims to challenge current regulatory approaches that do not recognize stereochemistry of chiral pharmaceuticals by testing the hypothesis that environmental transformation and effects of chiral pharmaceuticals are stereoselective. Our experiments revealed that, while degradation of chiral fluoxetine (FL) in river water occurs via non-enantioselective photochemical and mildly-enantioselective microbial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)-FL (leading to the formation of (S)-NFL (norfluoxetine)) is observed during activated sludge treatment...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136241/wikipathways-a-multifaceted-pathway-database-bridging-metabolomics-to-other-omics-research
#2
Denise N Slenter, Martina Kutmon, Kristina Hanspers, Anders Riutta, Jacob Windsor, Nuno Nunes, Jonathan Mélius, Elisa Cirillo, Susan L Coort, Daniela Digles, Friederike Ehrhart, Pieter Giesbertz, Marianthi Kalafati, Marvin Martens, Ryan Miller, Kozo Nishida, Linda Rieswijk, Andra Waagmeester, Lars M T Eijssen, Chris T Evelo, Alexander R Pico, Egon L Willighagen
WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database in a curated, machine readable way, omics data analysis and visualization is enabled. WikiPathways and other pathway databases are used to analyze experimental data by research groups in many fields. Due to the open and collaborative nature of the WikiPathways platform, our content keeps growing and is getting more accurate, making WikiPathways a reliable and rich pathway database. Previously, however, the focus was primarily on genes and proteins, leaving many metabolites with only limited annotation...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29132408/using-semantics-for-representing-experimental-protocols
#3
Olga Giraldo, Alexander García, Federico López, Oscar Corcho
BACKGROUND: An experimental protocol is a sequence of tasks and operations executed to perform experimental research in biological and biomedical areas, e.g. biology, genetics, immunology, neurosciences, virology. Protocols often include references to equipment, reagents, descriptions of critical steps, troubleshooting and tips, as well as any other information that researchers deem important for facilitating the reusability of the protocol. Although experimental protocols are central to reproducibility, the descriptions are often cursory...
November 13, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29128347/routine-use-of-pico-dressings-may-reduce-overall-groin-wound-complication-rates-following-peripheral-vascular-surgery
#4
Christina A Fleming, Mariya Kuteva, Karen O'Hanlon, Gavin O'Brien, Gerald McGreal
BACKGROUND: Approximately 19% of morbidity in peripheral vascular surgery is attributable to wound complications, which can result in delayed healing, but also arterial or graft infection leading to limb loss and even mortality in extreme cases. AIM: To determine whether groin wound complications were reduced following the routine introduction of PICO negative pressure wound therapy dressings (Smith & Nephew, Hull, England) in patients who had peripheral vascular surgery...
November 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29120177/zinc-complexes-with-cyanoxime-structural-spectroscopic-and-catalysis-studies-in-the-pivaloylcyanoxime-zn-system
#5
Adedamola A Opalade, Anirban Karmakar, G M D M Rúbio, Armando J L Pombeiro, Nikolay Gerasimchuk
Reaction of 2-hydroxyimino-4,4-dimethyl-3-oxo-pentanenitrile (common abbreviation HPiCO, pivaloyl-cyanoxime) with zinc sulfate in an aqueous solution results in the formation of the two new complexes: [Zn(PiCO){H(PiCO)2}(H2O)] (I) and tetranuclear Zn complex [Zn4(μ(3)-OH)2(PiCO)6 (H2O)4] (II). Both complexes were characterized by elemental analysis, IR- and UV-visible spectra, DSC/TGA studies, and X-ray analysis. In complex II, the PiCO(-) cyanoxime anion adopts three bidentate binding modes: O-monodentate, chelating (κ(2)), and bridging (η(2)) coordinations...
November 9, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29117634/spatial-variability-of-marine-bacterial-and-archaeal-communities-along-the-particulate-matter-continuum
#6
Mireia Mestre, Isabel Ferrera, Encarna Borrull, Eva Ortega-Retuerta, Susan Mbedi, Hans-Peter Grossart, M Montserrat Sala
Biotic and abiotic particles shape the microspatial architecture that defines the microbial aquatic habitat, being particles highly variable in size and quality along oceanic horizontal and vertical gradients. We analyzed the prokaryotic (bacterial and archaeal) diversity and community composition present in 6 distinct particle size classes ranging from the pico- to the microscale (0.2 to 200 μm). Further, we studied their variations along oceanographic horizontal (from the coast to open oceanic waters) and vertical (from the ocean surface into the meso- and bathypelagic ocean) gradients...
November 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29114335/imaging-of-the-unstable-shoulder
#7
Paolo Baudi, Manuela Rebuzzi, Giovanni Matino, Fabio Catani
Background: Unstable shoulder can occur in different clinical scenarios with a broad spectrum of symptoms and presentations: first-time (or recurrent) traumatic acute shoulder anterior dislocation or chronic anterior instability after repeated dislocations.Imaging in unstable shoulder is fundamental for choosing the right treatment preventing recurrence.The goal of imaging depends on clinical scenario and patient characteristics. Method: Careful selection and evaluation of the imaging procedures is therefore essential to identify, characterize and quantify the lesions...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29112324/de-novo-assembly-of-the-zucchini-genome-reveals-a-whole-genome-duplication-associated-with-the-origin-of-the-cucurbita-genus
#8
Javier Montero-Pau, José Blanca, Aureliano Bombarely, Peio Ziarsolo, Cristina Esteras, Carlos Martí-Gómez, María Ferriol, Pedro Gómez, Manuel Jamilena, Lukas Mueller, Belén Picó, Joaquín Cañizares
The Cucurbita genus (squashes, pumpkins and gourds) includes important domesticated species such as C. pepo, C. maxima and C. moschata. In this study, we present a high-quality draft of the zucchini (C. pepo) genome. The assembly has a size of 263 Mb, a scaffold N50 of 1.8 Mb, and 34,240 gene models. It includes 92% of the conserved BUSCO core gene set, and it is estimated to cover 93.0% of the genome. The genome is organized in 20 pseudomolecules that represent 81.4% of the assembly, and it is integrated with a genetic map of 7,718 SNPs...
November 7, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29111628/comparison-of-body-fat-percentage-of-male-soccer-players-of-different-competitive-levels-playing-positions-and-age-groups-a-meta-analysis
#9
Maamer Slimani, Hela Znazen, Amri Hammami, Nicola L Bragazzi
INTRODUCTION: The aim of the present meta-analysis was to compare the body fat percentage (%) between male soccer players of different competitive levels, playing positions and age groups. EVIDENCE ACQUISITION: The systematic search was conducted using different databases and according to the Population/Intervention or Exposure/Comparison/Outcome(s) [PICO] criteria. EVIDENCE SYNTHESIS: Higher % values of body fat in lower-level soccer players than higher-level counterparts (ES=0...
November 7, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29109044/target-vs-non-target-analysis-to-determine-pesticide-residues-in-fruits-from-saudi-arabia-and-influence-in-potential-risk-associated-with-exposure
#10
Yolanda Picó, Mohamed A El-Sheikh, Ahmed H Alfarhan, Damià Barceló
The occurrence of pesticide residues in fruits was determined by a target method for 62 analytes and a wide scope screening method against a database of 500 pesticides. Limits of quantification (LOQs) were from 0.5 to 6.3 μg kg(-1) for the target method and from 0.5 to 119 μg kg(-1) for the non-target. Thirty samples: dates, apples, oranges, tangerines, lemons and grapefruits were selected because their high consumption, except lemons and grapefruits that were to cover all citrus fruits. Using the target method, 15 compounds (mostly insecticides and fungicides) out of 62 pesticides (organophosphorus, carbamates, pyrethroids, chloroacetanilides, triazines, triazoles, imidazoles, etc...
November 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29107955/the-impact-of-financial-incentives-on-the-implementation-of-asthma-or-diabetes-self-management-a-systematic-review
#11
Tracy Jackson, Michael D Shields, Liam G Heaney, Marilyn Kendall, Christina J Pearce, Chi Yan Hui, Hilary Pinnock
INTRODUCTION: Financial incentives are utilised in healthcare systems in a number of countries to improve quality of care delivered to patients by rewarding practices or practitioners for achieving set targets. OBJECTIVES: To systematically review the evidence investigating the impact of financial incentives for implementation of supported self-management on quality of care including: organisational process outcomes, individual behavioural outcomes, and health outcomes for individuals with asthma or diabetes; both conditions with an extensive evidence base for self-management...
2017: PloS One
https://www.readbyqxmd.com/read/29098565/immunodeficiency-in-bloom-s-syndrome
#12
Michiel H D Schoenaker, Stefanie S Henriet, Jip Zonderland, Marcel van Deuren, Qiang Pan-Hammarström, Sandra J Posthumus-van Sluijs, Ingrid Pico-Knijnenburg, Corry M R Weemaes, Hanna IJspeert
Bloom's syndrome (BS) is an autosomal recessive disease, caused by mutations in the BLM gene. This gene codes for BLM protein, which is a helicase involved in DNA repair. DNA repair is especially important for the development and maturation of the T and B cells. Since BLM is involved in DNA repair, we aimed to study if BLM deficiency affects T and B cell development and especially somatic hypermutation (SHM) and class switch recombination (CSR) processes. Clinical data of six BS patients was collected, and immunoglobulin serum levels were measured at different time points...
November 2, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29091259/meta-analysis-of-microsatellite-instability-in-relation-to-clinicopathological-characteristics-and-overall-survival-in-gastric-cancer
#13
REVIEW
K Polom, L Marano, D Marrelli, R De Luca, G Roviello, V Savelli, P Tan, F Roviello
BACKGROUND: Several associations between microsatellite instability (MSI) and other clinicopathological factors have been reported in gastric cancer, but the results have been ambiguous. This systematic review and meta-analysis investigated the relationship between MSI and overall survival and clinicopathological characteristics of patients with gastric cancer. METHODS: A systematic literature search of the PubMed, Cochrane and Ovid databases until 31 January 2016 was performed in accordance with the PRISMA statement...
November 1, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29080708/classification-of-cough-as-a-symptom-in-adults-and-management-algorithms-chest-guideline-and-expert-panel-report
#14
Richard S Irwin, Cynthia L French, Anne B Chang, Kenneth W Altman
BACKGROUND: We performed systematic reviews using the population, intervention, comparison, outcome (PICO) format to answer the following key clinical question: Are the CHEST 2006 classifications of acute, subacute and chronic cough and associated management algorithms in adults that were based on durations of cough useful? METHODS: We used the CHEST Expert Cough Panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework...
November 9, 2017: Chest
https://www.readbyqxmd.com/read/29068229/direct-observation-of-a-photochemical-alkyne-allene-reaction-and-of-a-twisted-and-rehybridized-intramolecular-charge-transfer-state-in-a-donor-acceptor-dyad
#15
Bogdan Dereka, Denis Svechkarev, Arnulf Rosspeintner, Maximilian Tromayer, Robert Liska, Aaron M Mohs, Eric Vauthey
The excited-state dynamics of an aniline-triazine electron donor-acceptor dyad with an alkyne spacer has been investigated using a combination of ultrafast broadband mid-IR and visible transient absorption and fluorescence spectroscopies. The transient IR data reveal the occurrence of an efficient alkyne to allene isomerization of the spacer with a time constant increasing from a few hundreds of femtoseconds to a few picoseconds with solvent viscosity. This process is faster than the vibrational cooling of the Franck-Condon excited state, indicative of nonequilibrium dynamics...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29067720/magnetic-susceptibility-study-of-sub-pico-emu-sample-using-a-micromagnetometer-an-investigation-through-bistable-spin-crossover-materials
#16
Souleymane Kamara, Quang-Hung Tran, Vincent Davesne, Gautier Félix, Lionel Salmon, Kunwoo Kim, CheolGi Kim, Azzedine Bousseksou, Ferial Terki
A promising and original method to study the spin-transition in bistable spin-crossover (SCO) materials using a magnetoresistive multiring sensor and its self-generated magnetic field is reported. Qualitative and quantitative studies are carried out combining theoretical and experimental approaches. The results show that only a small part of matter dropped on the sensor surface is probed by the device. At a low bias-current range, the number of detected nanoparticles depends on the amplitude of the current...
October 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29066933/healthy-lifestyle-behavior-and-risk-of-long-duration-troublesome-neck-pain-or-low-back-pain-among-men-and-women-results-from-the-stockholm-public-health-cohort
#17
Eva Skillgate, Oscar Javier Pico-Espinosa, Johan Hallqvist, Tony Bohman, Lena W Holm
BACKGROUND: The role of healthy lifestyle behavior (HLB) in terms of physical activity, alcohol intake, smoking, and diet put together has not yet been explored for the risk of low back pain (LBP) and neck pain (NP). Our aim was to study if an HLB is protective against the onset of long duration troublesome LBP and NP in men and women. METHODS: Two cohorts from the Stockholm Public Health Cohort, free from LBP (n=12,483) and NP (n=10,539), respectively, in 2006, were surveyed with questionnaires...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29065439/do-adjuvants-add-to-the-efficacy-and-tolerance-of-bowel-preparations-a-meta-analysis-of-randomized-trials
#18
Sophie Restellini, Omar Kherad, Charles Menard, Myriam Martel, Alan N Barkun
Background and study aims Recommendations on adjuvant use with bowel preparations remain disparate. We performed a meta-analysis determining the clinical impact of adding an adjuvant to polyethylene glycol (PEG), sodium phosphate, picosulfate (PICO), or oral sulfate solutions (OSS)-based regimens. Methods Systematic searches were made of MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials from January 1980 to April 2016 that assessed preparations with or without adjuvants, given in split and non-split dosing, and PEG high- (> 3 L) or low-dose (≤ 2 L) regimens...
October 24, 2017: Endoscopy
https://www.readbyqxmd.com/read/29053658/low-level-laser-therapy-for-treatment-of-neurosensory-disorders-after-orthognathic-surgery-a-systematic-review-of-randomized-clinical-trials
#19
M-A-V Bittencourt, L-R Paranhos, P-R-S Martins-Filho
BACKGROUND: Low-level laser has been widely used in Dentistry and many studies have focused on its application in oral surgeries. This study was conducted with the aim of searching for scientific evidence concerning the effectiveness of laser to reduce pain or paresthesia related to orthognathic surgery. MATERIAL AND METHODS: An electronic search was performed in PubMed, Scopus, Science Direct, LILACS, SciELO, CENTRAL, Google Scholar, OpenGrey, and ClinicalTrials...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29052275/effectiveness-of-current-policing-related-mental-health-interventions-a-systematic-review
#20
Eddie Kane, Emily Evans, Farhad Shokraneh
BACKGROUND: There are three commonly used mental health interventions associated with policing: liaison and diversion, street triage and having specialist staff embedded in police contact control rooms. Crisis intervention teams (CITs), already used in the USA, are now attracting wider interest, including in the UK. Investment in these interventions is growing, so it is important to have evidence of their effectiveness. AIM: To conduct a systematic literature review to answer questions about effectiveness of police-mental health service models for responding to people with mental disorder and suspected offending or public safety problems...
October 19, 2017: Criminal Behaviour and Mental Health: CBMH
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