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https://www.readbyqxmd.com/read/28089913/physicians-perception-of-alternative-displays-of-clinical-research-evidence-for-clinical-decision-support-a-study-with-case-vignettes
#1
Stacey L Slager, Charlene R Weir, Heejun Kim, Javed Mostafa, Guilherme Del Fiol
OBJECTIVE: To design alternate information displays that present summaries of clinical trial results to clinicians to support decision-making; and to compare the displays according to efficacy and acceptability. METHODS: A 6-between (information display presentation order) by 3-within (display type) factorial design. Two alternate displays were designed based on Information Foraging theory: a narrative summary that reduces the content to a few sentences; and a table format that structures the display according to the PICO (Population, Intervention, Comparison, Outcome) framework...
January 13, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28079669/the-irish-helicobacter-pylori-working-group-consensus-for-the-diagnosis-and-treatment-of-h-pylori-infection-in-adult-patients-in-ireland
#2
Sinead Smith, Breida Boyle, Denise Brennan, Martin Buckley, Paul Crotty, Maeve Doyle, Richard Farrell, Mary Hussey, David Kevans, Peter Malfertheiner, Francis Megraud, Sean Nugent, Anthony O'Connor, Colm O'Morain, Shiobhan Weston, Deirdre McNamara
BACKGROUND: Irish eradication rates for Helicobacter pylori are decreasing and there is an increase in the prevalence of antibiotic-resistant bacteria. These trends call into question current management strategies. OBJECTIVE: To establish an Irish Helicobacter pylori Working Group (IHPWG) to assess, revise and tailor current available recommendations. METHODS: Experts in the areas of gastroenterology and microbiology were invited to join the IHPWG...
January 10, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28074972/correlated-non-correlated-ion-dynamics-of-charge-neutral-ion-couples-the-origin-of-ionicity-in-ionic-liquids
#3
G W Driver, Y Huang, A Laaksonen, T Sparrman, Y-L Wang, P-O Westlund
Proton/fluoride spin-lattice (T1) nuclear magnetic relaxation dispersion (NMRD) measurements of 1-butyl-3-methyl-1H-imidazolium hexafluorophosphate, [C4mim][PF6], have been carried out using high field spectrometers and a fast-field-cycling instrument at proton Larmor frequencies ranging from 10 kHz to 40 MHz, at different temperatures. The NMRD profiles are interpreted by means of a simple relaxation model based on the inter- and intra-ionic dipole-dipole relaxation mechanism. Using an atomic molecular-ion dynamic simulation at 323 K the relevant spin dipole-dipole (DD) correlation functions are calculated...
January 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28063304/splenic-irradiation-for-splenomegaly-a-systematic-review
#4
REVIEW
Nicholas G Zaorsky, Graeme R Williams, Stefan K Barta, Nestor F Esnaola, Patricia L Kropf, Shelly B Hayes, Joshua E Meyer
Splenic irradiation (SI) is a palliative treatment option for symptomatic splenomegaly (i.e. for pain, early satiety, pancytopenia from sequestration) secondary to hematologic malignancies and disorders. The purpose of the current article is to review the literature on SI for hematologic malignancies and disorders, including: (1) patient selection and optimal technique; (2) efficacy of SI; and (3) toxicities of SI. PICOS/PRISMA methods are used to select 27 articles including 766 courses of SI for 486 patients from 1960 to 2016...
December 22, 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28049404/cystic-fibrosis-mutation-detection-with-spr-biosensor-in-real-samples-via-multiple-surfaces-binding-method
#5
Yasin Ugur Kayran, Dilsat Ozkan-Ariksoysal, Seda Nur Topkaya, Burcin Tezcanli Kaymaz, Buket Kosova Can
Surface Plasmon Resonance (SPR) based biosensor system was developed for the detection of Delta F508 (DF508del) Cystic Fibrosis (CF) mutation in both synthetic and real samples. In order to provide an effective hybridization between probe and the Polymerase Chain Reaction (PCR) amplicons (target), streptavidin was bound to the surface and biotin-tag probe was sent to the streptavidin-coated surface. For the target preparation, blood samples were collected from the patients who suffer from CF. Following the DNA isolation; samples were amplified with PCR with biotin-tag...
January 3, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28040744/cohort-profile-the-transition-from-childhood-to-adolescence-in-european-children-how-i-family-extends-the-idefics-cohort
#6
W Ahrens, A Siani, R Adan, S De Henauw, G Eiben, W Gwozdz, A Hebestreit, M Hunsberger, J Kaprio, V Krogh, L Lissner, D Molnár, L A Moreno, A Page, C Picó, L Reisch, R M Smith, M Tornaritis, T Veidebaum, G Williams, H Pohlabeln, I Pigeot
No abstract text is available yet for this article.
December 31, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28040315/-barometer-of-type-2-diabetes-in-primary-care-metabolic-control-styles-of-life-and-morbidity-profile
#7
David Pérez-Manchón, María Lorena Rodríguez-Álvarez, Claudia Alcívar-Arteaga, Mercedes Redondo-Pico, Elena Ramos-Quirós
OBJECTIVE: Knowing the profile of cardiovascular morbidity, degree of control and lifestyles in type 2 diabetes. METHOD: Randomized multicenter cross-sectional study conducted in 2015 in primary care with 129 diabetics. It included sociodemographic variables, microvascular and macrovascular complications, organic damage, comorbidity and lifestyles of smoking, exercise and adherence to Mediterranean diet. Metabolic control was assessed with the latest annual glycosylated haemoglobin...
December 28, 2016: Enfermería Clínica
https://www.readbyqxmd.com/read/28040167/genetic-diversity-safety-and-technological-characterization-of-lactic-acid-bacteria-isolated-from-artisanal-pico-cheese
#8
M F P Domingos-Lopes, C Stanton, P R Ross, M L E Dapkevicius, C C G Silva
A total of 114 lactic acid bacteria were isolated at one and 21 days of ripening from a traditional raw cow's milk cheese without the addition of starter culture, produced by three artisanal cheese-makers in Azores Island (Pico, Portugal). Identification to species and strain level was accomplished by16S rRNA gene and PFGE analysis. Carbohydrate utilization profiles were obtained with the relevant API kits. Isolates were evaluated according to safety and technological criteria. The most frequently observed genus identified by 16S rRNA sequencing analysis was Enterococcus, whereas API system mostly identified Lactobacillus...
May 2017: Food Microbiology
https://www.readbyqxmd.com/read/28035694/a-narrative-meta-review-of-a-series-of-systematic-and-meta-analytic-reviews-on-the-intervention-outcome-for-children-with-developmental-co-ordination-disorder
#9
M Miyahara, M Lagisz, S Nakagawa, S E Henderson
BACKGROUND: Systematic reviews and meta-analyses are considered to be the 'gold standards' for synthesizing research evidence in particular areas of enquiry. However, such reviews are only useful if they themselves are conducted to a sufficiently high standard. The aim of this study was to conduct a narrative meta-review of existing analyses of the effectiveness of interventions designed for children with developmental co-ordination disorder (DCD). METHODS: A narrative meta-review of systematic and meta-analytic reviews aimed at evaluating the effectiveness of intervention for children with DCD was conducted on studies published between 1950 and 2014...
December 30, 2016: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28030502/operative-fixation-of-rib-fractures-after-blunt-trauma-a-practice-management-guideline-from-the-eastern-association-for-the-surgery-of-trauma
#10
George Kasotakis, Erik A Hasenboehler, Erik W Streib, Nimitt Patel, Mayur B Patel, Louis Alarcon, Patrick L Bosarge, Joseph Love, Elliott R Haut, John J Como
BACKGROUND: Rib fractures are identified in 10% of all injury victims and are associated with significant morbidity (33%) and mortality (12%). Significant progress has been made in the management of rib fractures over the last few decades, including operative reduction and internal fixation (rib ORIF); however, the subset of patients that would benefit most from this procedure remains ill-defined. The aim of this project was to develop evidence-based recommendations. METHODS: Population, intervention, comparison and outcome (PICO) questions were formulated for patients with and without flail chest...
December 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28028317/oral-leptin-supplementation-throughout-lactation-in-rats-prevents-later-metabolic-alterations-caused-by-gestational-calorie-restriction
#11
N Szostaczuk, T Priego, M Palou, A Palou, C Picó
OBJECTIVES: Calorie-restriction during gestation in rats has been seen to produce lasting detrimental effects in the offspring, affecting energy balance control and other related metabolic functions. Our aim was to assess whether leptin supplementation throughout lactation may prevent the dysmetabolic phenotype in adulthood associated with gestational calorie restriction. METHODS: Three groups of male Wistar rats were followed: the offspring of ad libitum fed dams (controls); the offspring of 20% calorie-restricted dams during gestation (CR); and CR rats supplemented with physiological doses of leptin throughout lactation (CR-Leptin)...
December 28, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28024877/neonatal-ovarian-cysts-ultrasound-assessment-and-differential-diagnosis
#12
R Llorens Salvador, C Sangüesa Nebot, A Pacheco Usmayo, S Picó Aliaga, E Garcés Iñigo
Ovarian cysts are the most common abdominal cysts in female fetuses and newborn girls. Ultrasonography is the imaging technique of choice for diagnosing ovarian cysts because it makes it possible to differentiate them from other cystic lesions. Although most neonatal ovarian cysts regress in the first few months after birth, complications can occur during gestation or after birth. The manifestations of ovarian cysts on ultrasonography will depend on the complications. The management is controversial, although the current trend favors watchful waiting...
December 23, 2016: Radiología
https://www.readbyqxmd.com/read/28002776/using-modeling-tools-for-implementing-feasible-land-use-and-nature-conservation-governance-systems-in-small-islands-the-pico-island-azores-case-study
#13
J P Fernandes, M Freire, N Guiomar, A Gil
The present study deals with the development of systematic conservation planning as management instrument in small oceanic islands, ensuring open systems of governance, and able to integrate an informed and involved participation of the stakeholders. Marxan software was used to define management areas according a set of alternative land use scenarios considering different conservation and management paradigms. Modeled conservation zones were interpreted and compared with the existing protected areas allowing more fused information for future trade-outs and stakeholder's involvement...
December 18, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/28002714/hypothermia-for-neuroprotection-in-convulsive-status-epilepticus
#14
RANDOMIZED CONTROLLED TRIAL
Stephane Legriel, Virginie Lemiale, Maleka Schenck, Jonathan Chelly, Virginie Laurent, Fabrice Daviaud, Mohamed Srairi, Aicha Hamdi, Guillaume Geri, Thomas Rossignol, Julia Hilly-Ginoux, Julie Boisramé-Helms, Benjamin Louart, Isabelle Malissin, Nicolas Mongardon, Benjamin Planquette, Marina Thirion, Sybille Merceron, Emmanuel Canet, Fernando Pico, Yves-Roger Tran-Dinh, Jean-Pierre Bedos, Elie Azoulay, Matthieu Resche-Rigon, Alain Cariou
Background Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus. Methods In a multicenter trial, we randomly assigned 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventilation to hypothermia (32 to 34°C for 24 hours) in addition to standard care or to standard care alone; 268 patients were included in the analysis. The primary outcome was a good functional outcome at 90 days, defined as a Glasgow Outcome Scale (GOS) score of 5 (range, 1 to 5, with 1 representing death and 5 representing no or minimal neurologic deficit)...
22, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27999660/-pico-d-management-a-decision-aid-for-evidence-based-chiropractic-education-and-clinical-practice
#15
Lyndon G Amorin-Woods, Barrett E Losco
BACKGROUND: Various models and decision-making aids exist for chiropractic clinical practice. RESULTS: "PICO-D Man" (Patient-Intervention-Comparator-Outcome-Duration Management) is a decision-aid developed in an educational setting which field practitioners may also find useful for applying defensible evidence-based practice. Clinical decision-making involves understanding and evaluating both the proposed clinicalintervention(s) and the relevant and available management options with respect to describing the patient and their problem, clinical and cost effectiveness, safety, feasibility and time-frame...
2016: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/27995242/surface-acoustic-wave-enabled-pipette-on-a-chip
#16
Muhsincan Sesen, Citsabehsan Devendran, Sean Malikides, Tuncay Alan, Adrian Neild
Mono-disperse droplet formation in microfluidic devices allows the rapid production of thousands of identical droplets and has enabled a wide range of chemical and biological studies through repeat tests performed at pico-to-nanoliter volume samples. However, it is exactly this efficiency of production which has hindered the ability to carefully control the location and quantity of the distribution of various samples on a chip - the key requirement for replicating micro well plate based high throughput screening in vastly reduced volumetric scales...
December 20, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27989816/extractive-text-summarization-system-to-aid-data-extraction-from-full-text-in-systematic-review-development
#17
Duy Duc An Bui, Guilherme Del Fiol, John F Hurdle, Siddhartha Jonnalagadda
OBJECTIVES: Extracting data from publication reports is a standard process in systematic review (SR) development. However, the data extraction process still relies too much on manual effort which is slow, costly, and subject to human error. In this study, we developed a text summarization system aimed at enhancing productivity and reducing errors in the traditional data extraction process. METHODS: We developed a computer system that used machine learning and natural language processing approaches to automatically generate summaries of full-text scientific publications...
October 27, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27986630/molecular-mechanism-of-lysozyme-adsorption-onto-chemically-modified-alginate-guar-gum-matrix
#18
Ma Emilia Brassesco, Nadia Woitovich Valetti, Guillermo Picó
The equilibrium isotherms and adsorption kinetics of lysozyme (LZ) on epichlorohydrin (Epi) cross-linked alginate-guar gum (Alg-GG) matrix were studied. Adsorption kinetics followed a pseudo-first-order model while the equilibrium isotherm could be represented by the Freundlich equation. The maximal amount of LZ adsorbed onto this matrix was around 2.4mg per g of hydrated matrix at pH 7.00. The adsorption mechanism was associated to a simple diffusion process with a weak columbic interaction between LZ and the matrix...
December 13, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27986263/simulation-based-teaching-in-interventional-radiology-training-is-it-effective
#19
R Patel, R Dennick
AIM: To establish the educational effectiveness of simulation teaching in interventional radiology training. MATERIALS AND METHODS: Electronic databases (MEDLINE, ERIC, Embase, OvidSP, and Cochrane Library) were searched (January 2000 to May 2015). Studies specifically with educational outcomes conducted on radiologists were eligible. All forms of simulation in interventional training were included. Data were extracted based on the population, intervention, comparison, and outcome (PICO) model...
December 13, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27982771/comparison-of-probabilistic-and-deterministic-fiber-tracking-of-cranial-nerves
#20
Amir Zolal, Stephan B Sobottka, Dino Podlesek, Jennifer Linn, Bernhard Rieger, Tareq A Juratli, Gabriele Schackert, Hagen H Kitzler
OBJECTIVE The depiction of cranial nerves (CNs) using diffusion tensor imaging (DTI) is of great interest in skull base tumor surgery and DTI used with deterministic tracking methods has been reported previously. However, there are still no good methods usable for the elimination of noise from the resulting depictions. The authors have hypothesized that probabilistic tracking could lead to more accurate results, because it more efficiently extracts information from the underlying data. Moreover, the authors have adapted a previously described technique for noise elimination using gradual threshold increases to probabilistic tracking...
December 16, 2016: Journal of Neurosurgery
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