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Msu and arthritis

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https://www.readbyqxmd.com/read/27863506/interleukin-37-limits-monosodium-urate-crystal-induced-innate-immune-responses-in-human-and-murine-models-of-gout
#1
Lei Liu, Yu Xue, Yingfeng Zhu, Dandan Xuan, Xue Yang, Minrui Liang, Juan Wang, Xiaoxia Zhu, Jiong Zhang, Hejian Zou
BACKGROUND: Interleukin (IL)-37 has emerged as a fundamental inhibitor of innate immunity. Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals. In the current study, we assessed the preventive and therapeutic effect of recombinant human IL-37 (rhIL-37) in human and murine gout models. METHODS: We investigated the expression of IL-37 in patients with active and inactive gouty arthritis and assessed the effect of rhIL-37 in human and murine gout models: a human monocyte cell line (THP-1) and human synovial cells (containing macrophage-like and fibroblast-like synoviocytes) exposed to MSU crystals, a peritoneal murine model of gout and a murine gouty arthritis model...
November 18, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27837341/crystal-identification-of-synovial-fluid-aspiration-by-polarized-light-microscopy-an-online-test-suggesting-that-our-traditional-rheumatologic-competence-needs-renewed-attention-and-training
#2
D Berendsen, T Neogi, W J Taylor, N Dalbeth, T L Jansen
Testing a reading exercise for identification of several typical crystal such as the negatively birefringent needle-shaped crystals that are under polarized light microscopy is the gold standard for diagnosing gout. The objective of this study was to assess current performance of crystal identification by professionals involved in examining synovial fluid in routine care. Rheumatologists, trainees, lab technicians, and other physicians with an interest in crystal arthritis completed an online test. The test consisted of 30 images: 8 monosodium urate (MSU) crystals, 5 calcium pyrophosphate (CPP), 4 cholesterol, 2 depot methylprednisolone, 2 calcium oxalate, 2 rice bodies, 1 hydroxyapatite, 1 liquid lipid, 1 fibrin, 1 Charcot-Leyden, and 5 different artifacts...
November 11, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27584788/kinsenoside-screening-with-a-microfluidic-chip-attenuates-gouty-arthritis-through-inactivating-nf-%C3%AE%C2%BAb-signaling-in-macrophages-and-protecting-endothelial-cells
#3
Qiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-He, Zheng Yu-Hua, Han Xiu-Guo, Wang Yu-Gang, Fan Qi-Ming, Yang Shih-Mo, Tang Ting-Ting
Gouty arthritis is a rheumatic disease that is characterized by the deposition of monosodium urate (MSU) in synovial joints cause by the increased serum hyperuricemia. This study used a three-dimensional (3D) flowing microfluidic chip to screen the effective candidate against MSU-stimulated human umbilical vein endothelial cell (HUVEC) damage, and found kinsenoside (Kin) to be the leading active component of Anoectochilus roxburghi, one of the Chinese medicinal plant widely used in the treatment of gouty arthritis clinically...
2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27558643/overview-of-serum-uric-acid-treatment-targets-in-gout-why-less-than-6-mg-dl
#4
Gary Ruoff, N Lawrence Edwards
Gout is a progressive, painful, debilitating form of inflammatory arthritis. It is caused by factors that elevate the concentration of serum uric acid (sUA), leading to hyperuricemia (sUA >6.8 mg/dL). Continued elevated sUA can result in monosodium urate (MSU) crystal deposition in joints and soft tissues, and can cause acute and chronic inflammation. The prevalence of hyperuricemia and gout has increased over the last few decades, likely due to an aging population, changes in lifestyles and diet, and an increase in gout-associated comorbidities...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27487363/an-unusual-presentation-of-gout-tophi-in-the-middle-ear
#5
Ahmet Mutlu, Emine Dündar, Mete İşeri, Cengiz Erçin, Ayşe Cefle
Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium urate (MSU) crystals in joints and connective tissues. The most commonly involved joint is the first metatarsophalangeal joint. It may also present with nonspecific complaints caused by gouty tophi in unusual sites of the body such as the spine, bone, and middle ear. Such involvements can be disabling and impair the quality of life. In this report, we describe the case of a patient who had complaints of hearing loss and otorrhea...
August 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27447372/a-luteolin-loaded-electrospun-fibrous-implantable-device-for-potential-therapy-of-gout-attacks
#6
Yi Wang, Chao Luo, Guang Yang, Xiao Wei, Dian Liu, Shaobing Zhou
The recurrence of acute gout attacks remains an unsolved problem in clinical therapy. In order to tackle this problem, poly(ε-caprolactone) (PCL)/gelatin composite fibrous devices loaded with luteolin are presented via electrospinning for the therapy of gout and its recurrence. The luteolin-loaded fibrous device has the capability of inhibiting metabolic activities and reducing inflammation-associated cytokine productions (TNF-a, IL-1β, IL-6) that are secreted by lipopolysaccharide stimulated RAW 264.7 macrophages...
November 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27432278/zisheng-shenqi-decoction-ameliorates-monosodium-urate-crystal-induced-gouty-arthritis-in-rats-through-anti-inflammatory-and-anti-oxidative-effects
#7
Jieru Han, Ying Xie, Fangyu Sui, Chunhong Liu, Xiaowei Du, Chenggang Liu, Xiaoling Feng, Deyou Jiang
Based on traditional Chinese medicinal theories on gouty arthritis, Zisheng Shenqi decoction (ZSD), a novel Chinese medicinal formula, was developed due to its multiple functions, including reinforcing renal function, promoting blood circulation and relieving pain. In the present study, the effect of ZSD on monosodium urate (MSU) crystal-induced gouty arthritis in rats was investigated and the underlying mechanisms were examined. The data from these investigations showed that the injection of MSU crystals into the ankle joint cavity caused significant elevations in ankle swelling and inflammatory cell infiltration into the synovium, whereas these abnormal changes were markedly suppressed by oral administration of ZSD (40 mg/kg) for 7 days...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27268719/morin-a-dietary-bioflavonol-suppresses-monosodium-urate-crystal-induced-inflammation-in-an-animal-model-of-acute-gouty-arthritis-with-reference-to-nlrp3-inflammasome-hypo-xanthine-phospho-ribosyl-transferase-and-inflammatory-mediators
#8
Chitra Dhanasekar, Mahaboobkhan Rasool
The anti-inflammatory effect of morin, a dietary bioflavanol was explored on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. Morin treatment (30mg/kg b.wt) significantly attenuated the ankle swelling and the levels of lipid peroxidation, nitric oxide, serum pro-inflammatory cytokines (tumor necrosis factor (TNF) -α, interleukin (IL)-1β, and IL-6), monocyte chemoattractant protein (MCP)-1, vascular endothelial growth factor (VEGF), prostaglandin E2 (PGE2), and articular elastase along with an increased anti-oxidant status (catalase (CAT) and superoxide dismutase (SOD)) in the joint homogenate of MSU crystal-induced rats...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27267827/traditional-chinese-medicine-formula-xiaofeng-granules-suppressed-gouty-arthritis-animal-models-and-inhibited-the-proteoglycan-degradation-on-chondrocytes-induced-by-monosodium-urate
#9
Le Shi, Fangli Zhao, Fangfang Zhu, Yuqiong Liang, Fan Yang, Guangji Zhang, Li Xu, Lian Yin
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaofeng Granules (XF) is a kind of granules prepared by the famous traditional Chinese medicine formula for its efficiency in treating gouty diseases. AIM OF THE STUDY: We investigated the relevance between XF that made from Modified simiaowan (MSW) as the anti-gouty arthritis drugs and protective mechanisms for cartilage matrix in order to provide the evidence for new drug application. MATERIALS AND METHODS: In the present study, we evaluated the anti-gouty arthritis activity of XF in rats and rabbits models induced by MSU together with chondrocytes focusing on the link to proteoglycan degradation in vitro studies...
September 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27234527/epigallocatechin-gallate-inhibits-urate-crystals-induced-peritoneal-inflammation-in-c57bl-6-mice
#10
Jhih-Jia Jhang, Chi-Cheng Lu, Gow-Chin Yen
Gouty arthritis is a type of monosodium urate (MSU) crystals-induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and interleukin-1β (IL-1β) secretion. MSU is capable of activating IL-1β through a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome. Epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea with potent antioxidant activity, is effective to prevent rheumatoid arthritis and osteoarthritis...
May 28, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27219123/cytokine-profile-in-gout-inflammation-driven-by-il-6-and-il-18
#11
Nara Gualberto Cavalcanti, Cláudia Diniz Lopes Marques, Thiago Ubiratan Lins E Lins, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rêgo, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta
INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1β and IL-18. However, the association between serum cytokines levels and clinical manifestations of the disease is not yet well understood. We evaluated the serum profile of proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17A, IL-18, IL-22, and IL-23) and described their relationship with clinical and laboratory data...
July 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27206713/synovial-fluid-proteins-are-required-for-the-induction-of-interleukin-1%C3%AE-production-by-monosodium-urate-crystals
#12
A Scanu, F Oliviero, L Gruaz, P Galozzi, R Luisetto, R Ramonda, D Burger, L Punzi
OBJECTIVES: Monosodium urate (MSU) crystal deposition in gouty joints promotes the release of inflammatory mediators, in particular interleukin (IL)-1β. The induction of IL-1β production by MSU crystals requires a co-stimulus. The objective of this study was to determine which part of the synovial fluid (SF) provides co-stimulation to MSU crystals to induce IL-1β in macrophages. METHOD: The lipidic fraction (LF) and the protein fraction (PF) were isolated from the SF of patients with arthropathies...
October 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27185589/relevant-aspects-of-imaging-in-the-diagnosis-and-management-of-gout
#13
Eloy De Avila Fernandes, Samuel Brighenti Bergamaschi, Tatiane Cantarelli Rodrigues, Gustavo Coelho Dias, Ralff Malmann, Germano Martins Ramos, Soraya Silveira Monteiro
Gout is an inflammatory arthritis characterized by the deposition of monosodium urate crystals (MSU) in the synovial membrane, articular cartilage and periarticular tissues leading to inflammation. Men are more commonly affected, mainly after the 5th decade of life. Its incidence has been growing with the population ageing. In the majority of the cases, the diagnosis is made by clinical criteria and synovial fluid analysis, in search for MSU crystals. Nonetheless, gout may sometimes have atypical presentations, complicating the diagnosis...
April 30, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27169898/alpk1-phosphorylates-myosin-iia-modulating-tnf-%C3%AE-trafficking-in-gout-flares
#14
Chi-Pin Lee, Shang-Lun Chiang, Albert Min-Shan Ko, Yu-Fan Liu, Che Ma, Chi-Yu Lu, Chung-Ming Huang, Jan-Gowth Chang, Tzer-Min Kuo, Chia-Lin Chen, Eing-Mei Tsai, Ying-Chin Ko
Gout is characterized by the monosodium urate monohydrate (MSU)-induced arthritis. Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Here, we used bioinformatics, proteomics, cell models, and twenty in vitro human assays to clarify some of its role in the inflammatory response to MSU. We found myosin IIA to be a frequent interacting protein partner of ALPK1, binding to its N-terminal and forming a protein complex with calmodulin and F-actin, and that MSU-induced ALPK1 phosphorylated the myosin IIA...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27138165/beyond-joints-a-review-of-ocular-abnormalities-in-gout-and-hyperuricemia
#15
REVIEW
Yael Sharon, Naomi Schlesinger
Gout is a common inflammatory arthritis among middle-aged men and postmenopausal women and can be a debilitating disease. Gout results from an elevated body uric acid pool, which leads to deposition of monosodium urate (MSU) crystals, mainly in and around the joints. The MSU crystals trigger release of proinflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Ocular manifestations have been uncommonly reported in patients with gout. These include descriptions of tophaceous deposits in different locations of the eye including the eyelids, conjunctiva, cornea, iris, sclera, and orbit...
June 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26989428/therapeutic-effects-of-chinese-medicine-herb-pair-huzhang-and-guizhi-on-monosodium-urate-crystal-induced-gouty-arthritis-in-rats-revealed-by-anti-inflammatory-assessments-and-nmr-based-metabonomics
#16
Bin Han, Huizhu Huang, Zhong Li, Mengjuan Gong, Wan Shi, Chunxia Zhu, Zulian Gu, Zhongjie Zou
The present study was undertaken to evaluate the therapeutic effects of Huzhang-Guizhi herb pair (HG), firstly included in Hu-Zhang Power documented in Taiping Shenghui Fang, on monosodium urate (MSU) crystals-induced gouty arthritis in rats. We found that pretreatment with HG in rats with gouty arthritis could significantly attenuate the ankle joint swelling, and this beneficial antigout effect might be mediated, at least in part, by inhibiting tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) production in synovial fluid as well as nuclear transcription factor-κB p65 (NF-κB p65) protein expression in synovial tissue...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26851531/targeting-inflammatory-mediators-with-ferulic-acid-a-dietary-polyphenol-for-the-suppression-of-monosodium-urate-crystal-induced-inflammation-in-rats
#17
Hari Madhuri Doss, Chandrima Dey, C Sudandiradoss, Mahaboob Khan Rasool
AIMS: The aim of this study was to investigate the anti-inflammatory effect of ferulic acid, a dietary phenol, on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. For the purpose of comparison, colchicine was used as a reference drug. MAIN METHODS: Paw edema, levels/activities of elastase, lysosomal enzymes (acid phosphatase and β-galactosidase), nitric oxide, lipid peroxidation, antioxidant status and pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β), and histology of ankle joints were evaluated in rats with MSU crystal-induced inflammation...
March 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/26709520/morin-a-bioflavonoid-suppresses-monosodium-urate-crystal-induced-inflammatory-immune-response-in-raw-264-7-macrophages-through-the-inhibition-of-inflammatory-mediators-intracellular-ros-levels-and-nf-%C3%AE%C2%BAb-activation
#18
Chitra Dhanasekar, Sowmiya Kalaiselvan, Mahaboobkhan Rasool
Our previous studies had reported that morin, a bioflavanoid exhibited potent anti-inflammatory effect against adjuvant-induced arthritic rats. In this current study, we investigated the anti-inflammatory mechanism of morin against monosodium urate crystal (MSU)-induced inflammation in RAW 264.7 macrophage cells, an in vitro model for acute gouty arthritis. For comparison purpose, colchicine was used as a reference drug. We have observed that morin (100-300 μM) treatment significantly suppressed the levels of inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1 and VEGF), inflammatory mediators (NO and PEG2), and lysosomal enzymes (acid phosphatase, β-galactosidase, N-acetyl glucosamindase and cathepsin D) in MSU-crystals stimulated macrophage cells...
2015: PloS One
https://www.readbyqxmd.com/read/26637956/suppressive-effect-of-sanmiao-formula-on-experimental-gouty-arthritis-by-inhibiting-cartilage-matrix-degradation-an-in-vivo-and-in-vitro-study
#19
Fangfang Zhu, Lian Yin, Leilei Ji, Fan Yang, Guangji Zhang, Le Shi, Li Xu
Sanmiao formula (SM) is a compound prescription, which has been used in traditional Chinese medicine since the Ming Dynasty for gouty and rheumatoid arthritis treatments. However, no evidence has been unfolded to show the relationship between SM and gouty arthritis (GA), particularly inhibiting cartilage matrix degradation. In the present study, we undertook a characterization of anti-GA activity of SM using an in vivo rat model induced by potassium oxonate and cold bath together with in vitro studies with chondrocytes for further molecular characterization...
January 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/26547220/il-37-inhibits-the-production-of-pro-inflammatory-cytokines-in-msu-crystal-induced-inflammatory-response
#20
Mei Zeng, Wantai Dang, Baofeng Chen, Yufeng Qing, Wenguang Xie, Mingcai Zhao, Jingguo Zhou
Acute gouty arthritis (AGA) is an auto-inflammatory disease characterized by resolving spontaneously, which suggests that negative feedback loops control inflammatory and immunological responses to monosodium urate (MSU) crystals. By now, the molecular mechanism for spontaneous resolution of acute GA remains unclear; this study was undertaken to evaluate whether IL-37 is involved in spontaneous resolution of AGA. A total of 45 acute GA (AGA),29 non-acute GA (NAGA) male patients and 82 male health control (HC) were involved in this study, we measured IL-7 expression in the peripheral blood mononuclear cells (PBMCs), together with levels of IL-1β, IL-6, IL-10, TNF-α and TGF-β1 in the serum...
September 2016: Clinical Rheumatology
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