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https://www.readbyqxmd.com/read/29352206/omega-3-carboxylic-acids-provide-efficacious-anti-inflammatory-activity-in-models-of-crystal-mediated-inflammation
#1
Cory Iverson, Andrew Bacong, Sha Liu, Scott Baumgartner, Torbjörn Lundström, Jan Oscarsson, Jeffrey N Miner
This study assesses the efficacy and exposure-response relationship of omega-3-carboxylic acids (OM-3 CA) in models of crystal-based inflammation. Human THP-1 macrophages and primary peripheral blood mononuclear cells exposed to multiple inflammatory crystal types were used to determine the anti-inflammatory potential of omega-3 (OM-3) fatty acids in vitro. Anti-inflammatory effects of OM-3 CA in vivo were tested in rat monosodium urate (MSU) crystal air pouch and rat knee intra-articular MSU injection models...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319609/joint-nociceptor-nerve-activity-and-pain-in-an-animal-model-of-acute-gout-and-its-modulation-by-intra-articular-hyaluronan
#2
Aida Marcotti, Ana Miralles, Eduardo Dominguez, Eliseo Pascual, Ana Gomis, Carlos Belmonte, Elvira de la Peña
The mechanisms whereby monosodium urate (MSU) crystals deposition in gout activate nociceptors to induce joint pain are incompletely understood. We tried to reproduce the signs of painful gouty arthritis, injecting into the knee joint of rats suspensions containing amorphous or triclinic, needle MSU crystals. The magnitude of MSU-induced inflammation and pain behavior signs was correlated with the changes in firing frequency of spontaneous and movement-evoked nerve impulse activity recorded in single knee joint nociceptor saphenous nerve fibers...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29214547/association-of-nlrp3-polymorphisms-with-susceptibility-to-primary-gouty-arthritis-in-a-chinese-han-population
#3
Quan-Bo Zhang, Yu-Feng Qing, Yong-Long He, Wen-Guang Xie, Jing-Guo Zhou
The NLRP3-interleukin1β (IL1β) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. The aim of this present study was to determine whether single nucleotide polymorphisms (SNPs) in the NLRP3 gene are associated with susceptibility to gouty arthritis (GA) and whether these SNPs alter the expression of components of the NLRP3-IL1β signaling pathway. The rs10754558, rs4612666, and rs1539019 SNPs were detected in 583 patients with GA and 459 healthy subjects. NLRP3 and IL1β mRNA levels in peripheral blood mononuclear cells (PBMCs) and serum IL1β levels were measured in different genotype carriers, and correlations between the NLRP3 SNPs and NLRP3 mRNA, IL1β mRNA, and serum IL1β levels were investigated...
December 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29174375/actinidia-arguta-extract-attenuates-inflammasome-activation-potential-involvement-in-nlrp3-ubiquitination
#4
Kang-Hyuck Heo, Xiao Sun, Do-Wan Shim, Myong-Ki Kim, Sushruta Koppula, Sang-Hyeun Yu, Han-Bi Kim, Tack-Joong Kim, Tae-Bong Kang, Kwang-Ho Lee
ETHNOPHARMACOLOGICAL RELEVANCE: Actinidia arguta (A. arguta) has been widely used in Asian countries as a traditional medicinal herb to treat inflammation-related diseases, such as gastritis, bronchitis, and arthritis. AIM OF THE STUDY: The inhibitory effect of A. arguta leaves' extract (AA) on inflammasome activation was investigated to verify its traditional use in treating inflammation-related diseases. MATERIALS AND METHODS: Bone marrow-derived macrophages (BMDMs) primed by lipopolysaccharide (LPS) were activated by selective inflammasome stimulators, and the effect of AA on inflammasome activation was investigated...
November 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29115078/elderly-patients-exhibit-stronger-inflammatory-responses-during-gout-attacks
#5
Jae Hyun Lee, Ji Ae Yang, Kichul Shin, Ga Hye Lee, Won Woo Lee, Eun Young Lee, Yeong Wook Song, Eun Bong Lee, Jin Kyun Park
Gout attacks are often accompanied by systemic inflammatory response. The aim of the retrospective study was to compare gout patients in different age groups in terms of their clinical features at gout attacks. Patients, who were treated for gout attack in two tertiary medical centers between January 2000 and April 2014, were divided into young (≤ 50 years), middle-aged, and elderly (> 65 years) groups. Patients in three age groups were compared in terms of presence of fever (> 37.8°C), C-reactive protein (CRP) levels, and erythrocyte sedimentation ratio (ESR) at the gout attacks...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29090559/-liver-metabonomics-of-acute-gouty-arthritis-treated-by-diosocorea-nipponica
#6
Shu-Min Liu, Ning Zhang, Dong-Hua Yu, Yu Wang, Qi Zhou, Fang Lu
To explore the prevention and protection effect of Diosocorea nipponica (DNM)) on acute gouty arthritis (AGA) rats based on liver metabonomics, and find potential biomarkers and related pathways. AGA model rats were induced by monosodium urate crystal suspension. UPLC-TOF-MS coupled with pattern recognition technique was employed to find out the potential biomarkers and related metabolic pathways. Eleven common potential biomarkers were identified. Among the potential intervention targets in normal rats given by DNM, 4 biomarkers were up-regulated, and the other 4 targets were down regulated...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28982129/the-tyrosine-kinase-inhibitor-imatinib-mesylate-suppresses-uric-acid-crystal-induced-acute-gouty-arthritis-in-mice
#7
Laurent L Reber, Philipp Starkl, Bianca Balbino, Riccardo Sibilano, Nicolas Gaudenzio, Stephan Rogalla, Steven Sensarn, Dongmin Kang, Harini Raghu, Jeremy Sokolove, William H Robinson, Christopher H Contag, Mindy Tsai, Stephen J Galli
Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody-dependent arthritis and in rheumatoid arthritis in humans, but to date, the potential effects of such inhibitors on gouty arthritis has not been evaluated. Here we demonstrate that treatment with the tyrosine kinase inhibitor imatinib mesylate (imatinib) can suppress inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type mice...
2017: PloS One
https://www.readbyqxmd.com/read/28939019/anti-inflammatory-effects-of-traditional-mixed-extract-of-medicinal-herbs-memh-on-monosodium-urate-crystal-induced-gouty-arthritis
#8
Ju-Suk Nam, Supriya Jagga, Ashish Ranjan Sharma, Joon-Hee Lee, Jong Bong Park, Jun-Sub Jung, Sang-Soo Lee
Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs (MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate (MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro...
August 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28929115/anti-gouty-arthritis-and-antihyperuricemia-effects-of-sunflower-helianthus-annuus-head-extract-in-gouty-and-hyperuricemia-animal-models
#9
Lanzhou Li, Meiyu Teng, Yange Liu, Yidi Qu, Yuanzhu Zhang, Feng Lin, Di Wang
This study was performed to investigate the therapeutic effects and possible mechanisms of sunflower (Helianthus annuus) head extract (SHE) on gout. First, the components of sunflower head powder and SHE were analyzed systematically. SHE, especially SHEB (extracted with 20% ethanol and 80% double-distilled water), strongly suppressed the swelling of the ankles in rats with acute gout induced by monosodium urate (MSU) crystals and reduced the levels of uric acid and xanthine oxidase (XO) in mice with hyperuricemia induced by oteracil potassium and yeast extract powder...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28915828/microrna-488-and-920-regulate-the-production-of-proinflammatory-cytokines-in-acute-gouty-arthritis
#10
Weidong Zhou, Ying Wang, Rongfeng Wu, Yan He, Qun Su, Guixiu Shi
BACKGROUND: Gout is considered one of the most painful acute conditions caused by deposition of monosodium urate (MSU) crystals within joints. Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). However, the molecular mechanisms of the regulation remain unclear. METHODS: A miRNA microarray was used to analyze the miRNA expression profiles in peripheral white blood cells (WBCs) of patients with GA...
September 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28880687/tnf-%C3%AE-potentiates-uric-acid-induced-interleukin-1%C3%AE-il-1%C3%AE-secretion-in-human-neutrophils
#11
Kohei Yokose, Shuzo Sato, Tomoyuki Asano, Makiko Yashiro, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Chikako Sato, Hideko Kozuru, Hiroshi Yatsuhashi, Kiyoshi Migita
OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1β (IL-1β) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive. In this study, we investigated the role of Tumor necrosis factor-alpha (TNF-α) on MSU-mediated IL-1β induction in human neutrophils. METHODS: Human neutrophils were stimulated with MSU, in the presence or absence of TNF-α priming...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28874151/effects-of-mollugo-pentaphylla-extract-on-monosodium-urate-crystal-induced-gouty-arthritis-in-mice
#12
Yun Mi Lee, Eun-Jung Shon, Ohn Soon Kim, Dong-Seon Kim
BACKGROUND: Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-induced gouty arthritis in a mouse model. METHOD: An MSU crystal suspension (4 mg/50 μL) was injected intradermally into the right paw...
September 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28812408/calcium-pyrophosphate-deposition-disease-a-frequent-finding-in-patients-with-long-standing-erosive-gout
#13
B Ankli, D Kyburz, A Hirschmann, T Hügle, T Manigold, C T Berger, T Daikeler
OBJECTIVE: To characterize patients with both monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals in their synovial fluid (SF). METHOD: Forty-nine gout patients with acute arthritis were included. Those patients with MSU crystals only in their SF were compared to those patients with both MSU and CPP crystals in their SF. RESULTS: A total of 36 out of 49 patients (73.5%) had only MSU crystals, whereas 13 out of 49 (26.5%) had both MSU and CPP crystals in their SF...
August 16, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28797095/single-nucleotide-polymorphisms-associated-with-p2x7r-function-regulate-the-onset-of-gouty-arthritis
#14
Jin-Hui Tao, Miao Cheng, Jiang-Ping Tang, Xiao-Juan Dai, Yong Zhang, Xiang-Pei Li, Qin Liu, Ya-Ling Wang
BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. However, some hyperuricemia patients, even gouty patients with tophi in the joints, never experience gout attack, which indicates that pathogenic pathways other than MSU participate in the secretion of IL-1β in the pathogenesis of acute gouty arthritis. The ATP-P2X7R-IL-1β axis may be one of these pathways. OBJECTIVE: This study examines the role of Adenosine triphosphate (ATP) in the pathogenesis of gout and the association of ATP receptor (P2X7R) function with single nucleotide polymorphisms and gout arthritis...
2017: PloS One
https://www.readbyqxmd.com/read/28748116/gout-an-old-disease-in-new-perspective-a-review
#15
REVIEW
Gaafar Ragab, Mohsen Elshahaly, Thomas Bardin
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28746185/clinical-significance-of-delta-neutrophil-index-in-the-differential-diagnosis-between-septic-arthritis-and-acute-gout-attack-within-24-hours-after-hospitalization
#16
Jung Yoon Pyo, Dae Sik Kim, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
The most important differential diagnoses of acute monoarticular arthritis are septic arthritis and acute gout attack. Identifying infection is crucial in preventing the devastating outcome of septic arthritis. The delta neutrophil index (DNI) is a value that corresponds to the fraction of circulating immature granulocytes. As DNI reflects the burden of infection, we evaluated this index as a differentiating marker between septic arthritis and acute gout attack.The medical records of 149 patients with septic arthritis and 194 patients with acute gout attack were reviewed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28732688/molecular-pathophysiology-of-gout
#17
REVIEW
Jyaysi Desai, Stefanie Steiger, Hans-Joachim Anders
Three contradictory clinical presentations of gout have puzzled clinicians and basic scientists for some time: first, the crescendo of sterile inflammation in acute gouty arthritis; second, its spontaneous resolution, despite monosodium urate (MSU) crystal persistence in the synovium; and third, immune anergy to MSU crystal masses observed in tophaceous or visceral gout. Here, we provide an update on the molecular pathophysiology of these gout manifestations, namely, how MSU crystals can trigger the auto-amplification loop of necroinflammation underlying the crescendo of acute gouty arthritis...
August 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28690186/ccl2-promoter-hypomethylation-is-associated-with-gout-risk-in-chinese-han-male-population
#18
Bin Li, Xiaoying Chen, Yuting Jiang, Yong Yang, Jie Zhong, Cong Zhou, Haochang Hu, Shiwei Duan
OBJECTIVES: C-C motif chemokine ligand 2 (CCL2) encodes a chemokine which amplifies and maintains inflammation through chemokine-cytokine networks. Gout is a type of painful inflammation arthritis in response to the deposition of monosodium urate (MSU) crystals in joints. The purpose of this study was to figure out the role of CCL2 promoter methylation in gout. METHODS: A quantitative methylation-specific polymerase chain reaction (qMSP) was used to measure CCL2 promoter methylation in 93 gout patients and 101 healthy controls, respectively...
October 2017: Immunology Letters
https://www.readbyqxmd.com/read/28630380/the-immunological-basis-in-the-pathogenesis-of-gout
#19
Junwei Chen, Meng Wu, Jinhua Yang, Jing Wang, Yue Qiao, Xiaofeng Li
Gout is an inflammatory arthritis characterized by red, tender, hot and tumid joints. The development cause and process of gout is very sophisticated; recent studies, notwithstanding, have offered novel perspectives on the mechanism from an immunological viewpoint. The pathological process of gout involves both innate and adaptive immune responses. Other studies have demonstrated that gout development is associated with the presence of monosodium urate (MSU) crystals which serve as a "danger signal" affecting certain immune cells, cytokine production, and effector molecule expression, triggering both types of immune responses...
June 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28623927/caffeoylquinic-acid-derivatives-rich-extract-from-gnaphalium-pensylvanicum-willd-ameliorates-hyperuricemia-and-acute-gouty-arthritis-in-animal-model
#20
Yan Jiang, Yan Lin, Yi-Juan Hu, Xiao-Jun Song, Hong-Hua Pan, Hong-Jian Zhang
BACKGROUND: The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. METHODS: G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition...
June 17, 2017: BMC Complementary and Alternative Medicine
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