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Msu and arthritis

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https://www.readbyqxmd.com/read/28167912/c5a-regulates-il-1%C3%AE-production-and-leukocyte-recruitment-in-a-murine-model-of-monosodium-urate-crystal-induced-peritonitis
#1
Hanif J Khameneh, Adrian W S Ho, Federica Laudisi, Heidi Derks, Matheswaran Kandasamy, Baalasubramanian Sivasankar, Gim Gee Teng, Alessandra Mortellaro
Gouty arthritis results from the generation of monosodium urate (MSU) crystals within joints. These MSU crystals elicit acute inflammation characterized by massive infiltration of neutrophils and monocytes that are mobilized by the pro-inflammatory cytokine IL-1β. MSU crystals also activate the complement system, which regulates the inflammatory response; however, it is unclear whether or how MSU-mediated complement activation is linked to IL-1β release in vivo, and the various roles that might be played by individual components of the complement cascade...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28089200/limitations-of-the-current-standards-of-care-for-treating-gout-and-crystal-deposition-in-the-primary-care-setting-a-review
#2
Robert T Keenan
PURPOSE: This article outlines several important issues regarding the management of patients with gout. The topics discussed include best practices for gout based on the most current guidelines, opportunities for improving gout management, and current and emerging therapies for gout. METHODS: [PubMed and Google Scholar databases] were search for all articles and trials published before 2016, using the key terms [hyperuricemia, gout, tophi, joint erosion, joint damage, treatment guidelines, American College of Rheumatology (ACR), European League Against Rheumatism (EULAR), flare, comorbidity, epidemiology, adherence, serum uric acid (sUA), monosodium urate (MSU), <6 mg/dL, MSU crystal formation, as well as individual drug names and classes of treatments of interest (allopurinol, febuxostat, colchicine, non-steroidal anti-inflammatories (NSAIDs)]...
January 11, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28068647/berberine-an-isoquinoline-alkaloid-suppresses-txnip-mediated-nlrp3-inflammasome-activation-in-msu-crystal-stimulated-raw-264-7-macrophages-through-the-upregulation-of-nrf2-transcription-factor-and-alleviates-msu-crystal-induced-inflammation-in-rats
#3
Palani Dinesh, MahaboobKhan Rasool
The current study was designed to investigate the therapeutic potential of berberine on monosodium urate (MSU) crystal stimulated RAW 264.7 macrophages and in MSU crystal induced rats. Our results indicate that berberine (25, 50 and 75μM) suppressed the levels of pro-inflammatory cytokines (interleukin-1beta (IL-1β) and tumor necrosis factor alpha (TNFα)) and intracellular reactive oxygen species in MSU crystal stimulated RAW 264.7 macrophages. The mRNA expression levels of IL-1β, caspase 1, nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3), thioredoxin interacting protein (TXNIP) and kelch-like ECH-associated protein 1 (Keap1) were found downregulated with the upregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) transcription factor and its associated anti-oxidant enzymes: Heme oxygenase I (HO-1), superoxide dismutase (SOD1), glutathione peroxidase (GPx), NADPH quinone oxidoreductase-1 (NQO1) and catalase (CAT) in MSU crystal stimulated RAW 264...
January 6, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27934918/targeting-asc-in-nlrp3-inflammasome-by-caffeic-acid-phenethyl-ester-a-novel-strategy-to-treat-acute-gout
#4
Hye Eun Lee, Gabsik Yang, Nam Doo Kim, Seongkeun Jeong, Yunjin Jung, Jae Young Choi, Hyun Ho Park, Joo Young Lee
Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome. The NLRP3 inflammasome, composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of various metabolic diseases including gouty arthritis. We investigated whether an orally administrable inhibitor of NLRP3 inflammasome was effective for alleviating the pathological symptoms of gouty arthritis and what was the underlying mechanism...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27863506/interleukin-37-limits-monosodium-urate-crystal-induced-innate-immune-responses-in-human-and-murine-models-of-gout
#5
Lei Liu, Yu Xue, Yingfeng Zhu, Dandan Xuan, Xue Yang, Minrui Liang, Juan Wang, Xiaoxia Zhu, Jiong Zhang, Hejian Zou
BACKGROUND: Interleukin (IL)-37 has emerged as a fundamental inhibitor of innate immunity. Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals. In the current study, we assessed the preventive and therapeutic effect of recombinant human IL-37 (rhIL-37) in human and murine gout models. METHODS: We investigated the expression of IL-37 in patients with active and inactive gouty arthritis and assessed the effect of rhIL-37 in human and murine gout models: a human monocyte cell line (THP-1) and human synovial cells (containing macrophage-like and fibroblast-like synoviocytes) exposed to MSU crystals, a peritoneal murine model of gout and a murine gouty arthritis model...
November 18, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27837341/crystal-identification-of-synovial-fluid-aspiration-by-polarized-light-microscopy-an-online-test-suggesting-that-our-traditional-rheumatologic-competence-needs-renewed-attention-and-training
#6
D Berendsen, T Neogi, W J Taylor, N Dalbeth, T L Jansen
Testing a reading exercise for identification of several typical crystal such as the negatively birefringent needle-shaped crystals that are under polarized light microscopy is the gold standard for diagnosing gout. The objective of this study was to assess current performance of crystal identification by professionals involved in examining synovial fluid in routine care. Rheumatologists, trainees, lab technicians, and other physicians with an interest in crystal arthritis completed an online test. The test consisted of 30 images: 8 monosodium urate (MSU) crystals, 5 calcium pyrophosphate (CPP), 4 cholesterol, 2 depot methylprednisolone, 2 calcium oxalate, 2 rice bodies, 1 hydroxyapatite, 1 liquid lipid, 1 fibrin, 1 Charcot-Leyden, and 5 different artifacts...
November 11, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27584788/kinsenoside-screening-with-a-microfluidic-chip-attenuates-gouty-arthritis-through-inactivating-nf-%C3%AE%C2%BAb-signaling-in-macrophages-and-protecting-endothelial-cells
#7
Qiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-He, Zheng Yu-Hua, Han Xiu-Guo, Wang Yu-Gang, Fan Qi-Ming, Yang Shih-Mo, Tang Ting-Ting
Gouty arthritis is a rheumatic disease that is characterized by the deposition of monosodium urate (MSU) in synovial joints cause by the increased serum hyperuricemia. This study used a three-dimensional (3D) flowing microfluidic chip to screen the effective candidate against MSU-stimulated human umbilical vein endothelial cell (HUVEC) damage, and found kinsenoside (Kin) to be the leading active component of Anoectochilus roxburghi, one of the Chinese medicinal plant widely used in the treatment of gouty arthritis clinically...
2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27558643/overview-of-serum-uric-acid-treatment-targets-in-gout-why-less-than-6-mg-dl
#8
REVIEW
Gary Ruoff, N Lawrence Edwards
Gout is a progressive, painful, debilitating form of inflammatory arthritis. It is caused by factors that elevate the concentration of serum uric acid (sUA), leading to hyperuricemia (sUA >6.8 mg/dL). Continued elevated sUA can result in monosodium urate (MSU) crystal deposition in joints and soft tissues, and can cause acute and chronic inflammation. The prevalence of hyperuricemia and gout has increased over the last few decades, likely due to an aging population, changes in lifestyles and diet, and an increase in gout-associated comorbidities...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27487363/an-unusual-presentation-of-gout-tophi-in-the-middle-ear
#9
Ahmet Mutlu, Emine Dündar, Mete İşeri, Cengiz Erçin, Ayşe Cefle
Gout is a common metabolic disease and is characterized by episodic acute and chronic arthritis caused by the deposition of monosodium urate (MSU) crystals in joints and connective tissues. The most commonly involved joint is the first metatarsophalangeal joint. It may also present with nonspecific complaints caused by gouty tophi in unusual sites of the body such as the spine, bone, and middle ear. Such involvements can be disabling and impair the quality of life. In this report, we describe the case of a patient who had complaints of hearing loss and otorrhea...
August 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27447372/a-luteolin-loaded-electrospun-fibrous-implantable-device-for-potential-therapy-of-gout-attacks
#10
Yi Wang, Chao Luo, Guang Yang, Xiao Wei, Dian Liu, Shaobing Zhou
The recurrence of acute gout attacks remains an unsolved problem in clinical therapy. In order to tackle this problem, poly(ε-caprolactone) (PCL)/gelatin composite fibrous devices loaded with luteolin are presented via electrospinning for the therapy of gout and its recurrence. The luteolin-loaded fibrous device has the capability of inhibiting metabolic activities and reducing inflammation-associated cytokine productions (TNF-a, IL-1β, IL-6) that are secreted by lipopolysaccharide stimulated RAW 264.7 macrophages...
November 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27432278/zisheng-shenqi-decoction-ameliorates-monosodium-urate-crystal-induced-gouty-arthritis-in-rats-through-anti-inflammatory-and-anti-oxidative-effects
#11
Jieru Han, Ying Xie, Fangyu Sui, Chunhong Liu, Xiaowei Du, Chenggang Liu, Xiaoling Feng, Deyou Jiang
Based on traditional Chinese medicinal theories on gouty arthritis, Zisheng Shenqi decoction (ZSD), a novel Chinese medicinal formula, was developed due to its multiple functions, including reinforcing renal function, promoting blood circulation and relieving pain. In the present study, the effect of ZSD on monosodium urate (MSU) crystal-induced gouty arthritis in rats was investigated and the underlying mechanisms were examined. The data from these investigations showed that the injection of MSU crystals into the ankle joint cavity caused significant elevations in ankle swelling and inflammatory cell infiltration into the synovium, whereas these abnormal changes were markedly suppressed by oral administration of ZSD (40 mg/kg) for 7 days...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27268719/morin-a-dietary-bioflavonol-suppresses-monosodium-urate-crystal-induced-inflammation-in-an-animal-model-of-acute-gouty-arthritis-with-reference-to-nlrp3-inflammasome-hypo-xanthine-phospho-ribosyl-transferase-and-inflammatory-mediators
#12
Chitra Dhanasekar, Mahaboobkhan Rasool
The anti-inflammatory effect of morin, a dietary bioflavanol was explored on monosodium urate (MSU) crystal-induced inflammation in rats, an experimental model for acute gouty arthritis. Morin treatment (30mg/kg b.wt) significantly attenuated the ankle swelling and the levels of lipid peroxidation, nitric oxide, serum pro-inflammatory cytokines (tumor necrosis factor (TNF) -α, interleukin (IL)-1β, and IL-6), monocyte chemoattractant protein (MCP)-1, vascular endothelial growth factor (VEGF), prostaglandin E2 (PGE2), and articular elastase along with an increased anti-oxidant status (catalase (CAT) and superoxide dismutase (SOD)) in the joint homogenate of MSU crystal-induced rats...
September 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27267827/traditional-chinese-medicine-formula-xiaofeng-granules-suppressed-gouty-arthritis-animal-models-and-inhibited-the-proteoglycan-degradation-on-chondrocytes-induced-by-monosodium-urate
#13
Le Shi, Fangli Zhao, Fangfang Zhu, Yuqiong Liang, Fan Yang, Guangji Zhang, Li Xu, Lian Yin
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaofeng Granules (XF) is a kind of granules prepared by the famous traditional Chinese medicine formula for its efficiency in treating gouty diseases. AIM OF THE STUDY: We investigated the relevance between XF that made from Modified simiaowan (MSW) as the anti-gouty arthritis drugs and protective mechanisms for cartilage matrix in order to provide the evidence for new drug application. MATERIALS AND METHODS: In the present study, we evaluated the anti-gouty arthritis activity of XF in rats and rabbits models induced by MSU together with chondrocytes focusing on the link to proteoglycan degradation in vitro studies...
September 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27234527/epigallocatechin-gallate-inhibits-urate-crystals-induced-peritoneal-inflammation-in-c57bl-6-mice
#14
Jhih-Jia Jhang, Chi-Cheng Lu, Gow-Chin Yen
Gouty arthritis is a type of monosodium urate (MSU) crystals-induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and interleukin-1β (IL-1β) secretion. MSU is capable of activating IL-1β through a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome. Epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea with potent antioxidant activity, is effective to prevent rheumatoid arthritis and osteoarthritis...
May 28, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27219123/cytokine-profile-in-gout-inflammation-driven-by-il-6-and-il-18
#15
Nara Gualberto Cavalcanti, Cláudia Diniz Lopes Marques, Thiago Ubiratan Lins E Lins, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rêgo, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta
INTRODUCTION: Gout is considered to be an autoinflammatory disease and the presence of monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and subsequently caspase-1, generating production of active IL-1β and IL-18. However, the association between serum cytokines levels and clinical manifestations of the disease is not yet well understood. We evaluated the serum profile of proinflammatory cytokines (IL-1β, IL-6, IL-8, IL-17A, IL-18, IL-22, and IL-23) and described their relationship with clinical and laboratory data...
July 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27206713/synovial-fluid-proteins-are-required-for-the-induction-of-interleukin-1%C3%AE-production-by-monosodium-urate-crystals
#16
A Scanu, F Oliviero, L Gruaz, P Galozzi, R Luisetto, R Ramonda, D Burger, L Punzi
OBJECTIVES: Monosodium urate (MSU) crystal deposition in gouty joints promotes the release of inflammatory mediators, in particular interleukin (IL)-1β. The induction of IL-1β production by MSU crystals requires a co-stimulus. The objective of this study was to determine which part of the synovial fluid (SF) provides co-stimulation to MSU crystals to induce IL-1β in macrophages. METHOD: The lipidic fraction (LF) and the protein fraction (PF) were isolated from the SF of patients with arthropathies...
October 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27185589/relevant-aspects-of-imaging-in-the-diagnosis-and-management-of-gout
#17
Eloy De Avila Fernandes, Samuel Brighenti Bergamaschi, Tatiane Cantarelli Rodrigues, Gustavo Coelho Dias, Ralff Malmann, Germano Martins Ramos, Soraya Silveira Monteiro
Gout is an inflammatory arthritis characterized by the deposition of monosodium urate crystals (MSU) in the synovial membrane, articular cartilage and periarticular tissues leading to inflammation. Men are more commonly affected, mainly after the 5th decade of life. Its incidence has been growing with the population ageing. In the majority of the cases, the diagnosis is made by clinical criteria and synovial fluid analysis, in search for MSU crystals. Nonetheless, gout may sometimes have atypical presentations, complicating the diagnosis...
April 30, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27169898/alpk1-phosphorylates-myosin-iia-modulating-tnf-%C3%AE-trafficking-in-gout-flares
#18
Chi-Pin Lee, Shang-Lun Chiang, Albert Min-Shan Ko, Yu-Fan Liu, Che Ma, Chi-Yu Lu, Chung-Ming Huang, Jan-Gowth Chang, Tzer-Min Kuo, Chia-Lin Chen, Eing-Mei Tsai, Ying-Chin Ko
Gout is characterized by the monosodium urate monohydrate (MSU)-induced arthritis. Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Here, we used bioinformatics, proteomics, cell models, and twenty in vitro human assays to clarify some of its role in the inflammatory response to MSU. We found myosin IIA to be a frequent interacting protein partner of ALPK1, binding to its N-terminal and forming a protein complex with calmodulin and F-actin, and that MSU-induced ALPK1 phosphorylated the myosin IIA...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27138165/beyond-joints-a-review-of-ocular-abnormalities-in-gout-and-hyperuricemia
#19
REVIEW
Yael Sharon, Naomi Schlesinger
Gout is a common inflammatory arthritis among middle-aged men and postmenopausal women and can be a debilitating disease. Gout results from an elevated body uric acid pool, which leads to deposition of monosodium urate (MSU) crystals, mainly in and around the joints. The MSU crystals trigger release of proinflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Ocular manifestations have been uncommonly reported in patients with gout. These include descriptions of tophaceous deposits in different locations of the eye including the eyelids, conjunctiva, cornea, iris, sclera, and orbit...
June 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/26989428/therapeutic-effects-of-chinese-medicine-herb-pair-huzhang-and-guizhi-on-monosodium-urate-crystal-induced-gouty-arthritis-in-rats-revealed-by-anti-inflammatory-assessments-and-nmr-based-metabonomics
#20
Bin Han, Huizhu Huang, Zhong Li, Mengjuan Gong, Wan Shi, Chunxia Zhu, Zulian Gu, Zhongjie Zou
The present study was undertaken to evaluate the therapeutic effects of Huzhang-Guizhi herb pair (HG), firstly included in Hu-Zhang Power documented in Taiping Shenghui Fang, on monosodium urate (MSU) crystals-induced gouty arthritis in rats. We found that pretreatment with HG in rats with gouty arthritis could significantly attenuate the ankle joint swelling, and this beneficial antigout effect might be mediated, at least in part, by inhibiting tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) production in synovial fluid as well as nuclear transcription factor-κB p65 (NF-κB p65) protein expression in synovial tissue...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
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