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Head and neck cancer

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https://www.readbyqxmd.com/read/29906455/randomized-clinical-trial-of-a-mucoadhesive-formulation-containing-curcuminoids-zingiberaceae-and-bidens-pilosa-linn-asteraceae-extract-fitoprot-for-prevention-and-treatment-of-oral-mucositis-phase-i-study
#1
Edvande Xavier Dos Santos Filho, Diego Antonio Costa Arantes, Angélica Ferreira Oton Leite, Aline Carvalho Batista, Elismauro Francisco de Mendonça, Ricardo Neves Marreto, Letícia Nasser Naves, Eliana Martins Lima, Marize Campos Valadares
Preclinical repeated-dose toxicity and efficiency studies developed by our group suggest the potential of FITOPROT in treating mucositis. This serious limiting side effect is observed at a rate of 40-100% in patients under antineoplastic therapy and despite different palliative measures and therapeutic agents have been investigated, still no therapy was completely successful. Therefore, this study aimed to establish the safety and recommended phase II dose of FITOPROT for the prevention and treatment of chemoradiotherapy-induced oral mucositis (OM) in patients with head and neck cancer...
June 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29906408/the-potential-for-liquid-biopsies-in-head-and-neck-cancer
#2
Matthew E Spector, Janice L Farlow, Catherine T Haring, J Chad Brenner, Andrew C Birkeland
Head and neck cancers consist of a heterogeneous group of cancers that are difficult to treat successfully. Limited screening options result in patients being diagnosed at advanced stages at presentation, and difficulty with treatment options and post-treatment surveillance can lead to poor outcomes. In this setting, tools for early and precise detection of disease will be highly valuable. Liquid biopsies, or use of analytes in blood, saliva, and other body fluid samples, provide new avenues for cancer screening with the potential for early detection, treatment modification, and surveillance of head and neck cancers...
May 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29905359/-robotic-surgery-who-is-the-boss
#3
Patrick J Schuler
In the head and neck region, great potential is seen in robot-assisted surgery (RAS). Mainly in cancer surgery, the use of robotic systems seems to be of interest. Until today, two robotic systems (DaVinci® und FLEX®) have gained approval for clinical use in the head and neck region, and multiple other systems are currently in pre-clinical testing. Although, certain groups of patients may benefit from RAS, no unbiased randomized clinical studies are available. Until today, it was not possible to satisfactorily prove any advantage of RAS as compared to standard procedures...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29905355/-radiomics-big-data-instead-of-biopsies-in-the-future
#4
Kathrin Scheckenbach
Precision medicine is increasingly pushed forward, also with respect to upcoming new targeted therapies. Individual characterization of diseases on the basis of biomarkers is a prerequisite for this development. So far, biomarkers are characterized clinically, histologically or on a molecular level. The implementation of broad screening methods ("Omics") and the analysis of big data - in addition to single markers - allow to define biomarker signatures. Next to "Genomics", "Proteomics", and "Metabolicis", "Radiomics" gained increasing interest during the last years...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29905354/-hpv-a-different-view-on-head-and-neck-cancer
#5
Claus Wittekindt, Steffen Wagner, Shachi Jenny Sharma, Nora Würdemann, Jennifer Knuth, Henrike Reder, Jens Peter Klußmann
Head and neck cancer is the sixth most common cancer with over 500000 annually reported incident cases worldwide. Besides major risk factors tobacco and alcohol, oropharyngeal squamous cell carcinomas (OSCC) show increased association with human papillomavirus (HPV). HPV-associated and HPV-negative OSCC are 2 different entities regarding biological characteristics, therapeutic response, and patient prognosis. In HPV OSCC, viral oncoprotein activity, as well as genetic (mutations and chromosomal aberrations) and epigenetic alterations plays a key role during carcinogenesis...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29904734/hazards-of-sparing-the-ipsilateral-parotid-gland-in-the-node-positive-neck-with-intensity-modulated-radiation-therapy-spatial-analysis-of-regional-recurrence-risk
#6
Allen M Chen, Taeko Yoshizaki, Pin-Chieh Wang, Darlene Veruttipong, Phillip J Beron, Robert Chin, Argin G Mikaeilian, Minsong Cao
Purpose: The practice of deliberately sparing the ipsilateral parotid gland with intensity modulated radiation therapy (IMRT) in patients with node-positive head and neck cancer is controversial. We sought to compare the clinical outcomes among consecutive cohorts of patients with head and neck cancer who were treated with differing strategies to spare the parotid gland that is ipsilateral to the involved neck using IMRT. Methods and materials: A total of 305 patients were treated with IMRT for node-positive squamous cell carcinoma of the head and neck...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904731/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-3-hispanic-american-patients
#7
Shearwood McClelland, Carmen A Perez
Purpose: Health disparities have profoundly affected underrepresented minorities throughout the United States, particularly with regard to access to evidence-based interventions such as surgery or medication. The degree of disparity in access to radiation therapy (RT) for Hispanic-American patients with cancer has not been previously examined in an extensive manner. Methods and materials: An extensive literature search was performed using the PubMed database to examine studies investigating disparities in RT access for Hispanic-Americans...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29903673/clinician-observed-and-patient-reported-toxicities-and-their-association-with-poor-tolerance-to-therapy-in-older-patients-with-head-and-neck-or-lung-cancer-treated-with-curative-radiotherapy
#8
Dominic H Moon, Bhishamjit S Chera, Allison M Deal, Yue Wang, Hyman B Muss, Noam A VanderWalde
OBJECTIVES: The agreement between clinician- and patient-reported toxicities and their association with poor tolerance to therapy were assessed in an older population receiving curative radiotherapy (RT). MATERIALS AND METHODS: Patients ≥ 65 years old with newly-diagnosed head and neck or lung cancer receiving curative RT ± chemotherapy were enrolled on a prospective, observational study. Agreement between clinician (CTCAEv4.02) and patient (PRO-CTCAE, EORTC QLQ-C30) report of toxicities were assessed at baseline, during treatment, and post-treatment...
June 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29903550/radiotherapy-utilization-and-fractionation-patterns-during-the-first-course-of-cancer-treatment-in-the-united-states-from-2004-to-2014
#9
Trevor J Royce, Muhammad M Qureshi, Minh Tam Truong
BACKGROUND: The changing use of radiation as a first-line cancer therapy in the United States is poorly characterized. This study aims to report radiotherapy utilization and fractionation patterns during the first course of cancer treatment. METHODS: We extracted all solid tumor cases from 2004 to 2014 in the National Cancer Data Base, which captures only the first course of treatment. Patients were subcategorized by disease site: breast, central nervous system (CNS), gastrointestinal, genitourinary, gynecologic, head and neck (HN), musculoskeletal, skin, or thoracic...
June 11, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29902298/prevalence-of-pdl1-amplification-and-preliminary-response-to-immune-checkpoint-blockade-in-solid-tumors
#10
Aaron M Goodman, David Piccioni, Shumei Kato, Amélie Boichard, Huan-You Wang, Garrett Frampton, Scott M Lippman, Caitlin Connelly, David Fabrizio, Vincent Miller, Jason K Sicklick, Razelle Kurzrock
Importance: Copy number alterations in programmed cell death ligand 1 (PDL1 or CD274), programmed cell death 1 ligand 2 (PDCD1LG2 or PDL2), and Janus kinase 2 (JAK2) genes (chromosome 9p24.1) characterize Hodgkin lymphoma, resulting in high response rates to programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) blockade. The prevalence and utility of PDL1 amplification as a response biomarker to PD-1/PD-L1 blockade are unknown in other tumors. Objectives: To examine the prevalence of PDL1 amplification and its utility as a response biomarker to PD-1/PD-L1 blockade in solid tumors...
June 14, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29901408/pain-is-associated-with-continuing-depression-in-cancer-survivors
#11
Patricia M Bamonti, Jennifer Moye, Aanand D Naik
Depression is common but under-diagnosed in cancer survivors. This study characterized depressive symptoms over one year in cancer survivors and examined disease-related and psychosocial predictors of depression severity. Participants (n = 122; Mage 65.33, SD = 9.17, 98.4% male) with head and neck, esophageal, gastric, or colorectal cancers were recruited through tumor registries at two regional Veterans Administration Medical Centers. Self-report measures assessing depressive symptoms (PHQ-9), combat-related PTSD symptoms (PC-PTSD), and health-related quality of life (PROMIS) were administered at six, twelve, and eighteen months after diagnosis...
June 14, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29901180/mg%C3%A2-132-reverses-multidrug-resistance-by-activating-the-jnk-signaling-pathway-in-fadu-t-cells
#12
Juke Ma, Zhenghua Lv, Xiuxiu Liu, Xianfang Liu, Wei Xu
Multidrug resistance (MDR) is a major impediment to cancer therapy. MG‑132 has been identified to be effective against MDR in several types of cancer. However, the mechanism of MG‑132 in head and neck squamous cell carcinomas remains unknown. Based on our previous study, the present detected P‑gp and P‑gp expression in hypopharyngeal carcinoma FaDu cells, revealing that their expression was lower than that observed in the MDR cell line FaDu/T. To reverse the MDR of FaDu/T cells, the present study introduced MG‑132 and demonstrated that the high expression of P‑gp/P‑gp in FaDu/T cells was attenuated in a time‑dependent manner...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29899842/high-throughput-testing-in-head-and-neck-squamous-cell-carcinoma-identifies-agents-with-preferential-activity-in-human-papillomavirus-positive-or-negative-cell-lines
#13
Farhad Ghasemi, Morgan Black, Ren X Sun, Frederick Vizeacoumar, Nicole Pinto, Kara M Ruicci, John Yoo, Kevin Fung, Danielle MacNeil, David A Palma, Eric Winquist, Joe S Mymryk, Laurie A Ailles, Alessandro Datti, John W Barrett, Paul C Boutros, Anthony C Nichols
Head and neck squamous cell carcinoma (HNSCC) is a common cancer diagnosis worldwide. Despite advances in treatment, HNSCC has very poor survival outcomes, emphasizing an ongoing need for development of improved therapeutic options. The distinct tumor characteristics of human papillomavirus (HPV)-positive vs . HPV-negative disease necessitate development of treatment strategies tailored to tumor HPV-status. High-throughput robotic screening of 1,433 biologically and pharmacologically relevant compounds at a single dose (4 μM) was carried out against 6 HPV-positive and 20 HPV-negative HNSCC cell lines for preliminary identification of therapeutically relevant compounds...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29898466/-correction-validation-of-the-german-version-of-eating-assessment-tool-for-head-and-neck-cancer-patients
#14
Eugen Zaretsky, Silke Steinbach-Hundt, Petra Pluschinski, Isabel Grethel, Christiane Hey
No abstract text is available yet for this article.
June 13, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29898433/electrochemotherapy-with-cisplatin-or-bleomycin-in-head-and-neck-squamous-cell-carcinoma-improved-effectiveness-of-cisplatin-in-hpv-positive-tumors
#15
Ajda Prevc, Martina Niksic Zakelj, Simona Kranjc, Maja Cemazar, Janez Scancar, Tina Kosjek, Primoz Strojan, Gregor Sersa
Human papillomavirus (HPV) is an important etiological factor in head and neck squamous cell carcinomas (SCCs). Standard treatment of HPV-positive tumors with platinum-based radio(chemo)therapy results in a better outcome than in HPV-negative tumors. Electrochemotherapy is becoming an increasingly recognized mode of treatment in different cancers; thus, its use in the management of head and neck SCC is of considerable interest. However, response to electrochemotherapy according to HPV status of the tumors has not been evaluated yet...
June 6, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29898038/transcutaneous-electrical-nerve-stimulation-tens-on-hyposalivation-induced-by-radiotherapy-in-the-head-and-neck-region-a-preliminary-study
#16
Émille Dalbem Paim, Fabricio Edler Macagnan, Vera Beatris Martins, Virgilio Gonzales Zanella, Bruno Guimarães, Monalise Costa Batista Berbert
PURPOSE: To verify the acute effect of electrostimulation on the salivary flow of patients with hyposalivation. METHODS: Uncontrolled clinical trial evaluating 15 patients with hyposalivation induced by radiotherapy (RT) used for head and neck cancer treatment. Mean age of the patients was 56.8 ± 6.46 years. Males outnumbered females (73%). Transcutaneous Electrical Nerve Stimulation (TENS) was adjusted with 50Hz of frequency and 250μs of pulse width. Intensity was adjusted over a 20-minute period according to maximum tolerance...
June 7, 2018: CoDAS
https://www.readbyqxmd.com/read/29897817/persistent-disruption-of-lateral-junctional-complexes-and-actin-cytoskeleton-in-parotid-salivary-glands-following-radiation-treatment
#17
Wen Yu Wong, Maricela Pier, Kirsten H Limesand
Xerostomia and hyposalivation are debilitating side effects for patients treated with ionizing radiation for head and neck cancer. Despite technological advances, collateral damage to the salivary glands remains a significant problem for patients and severely diminishes their quality of life. During the wound healing process, restoration of junctional contacts is necessary to maintain polarity, structural integrity, and orientation cues for secretion. However, little is known about whether these structural molecules are impacted following radiation damage and more importantly during tissue restoration...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29896916/establishing-action-threshold-for-change-in-patient-anatomy-using-epid-gamma-analysis-and-ptv-coverage-for-head-and-neck-radiotherapy-treatment
#18
Ophelie Piron, Nicolas Varfalvy, Louis Archambault
PURPOSE: To present a new adaptive radiotherapy (ART) method based on relative gamma analysis and patient classification for the identification of anatomical changes that induce a sufficient dosimetric impact to affect the treatment delivery and require complete replanning. METHODS: This retrospective study includes 55 patients treated for a head and neck cancer with IMRT, VMAT or 3D conformal RT. EPID images for all treatment fields were acquired daily at every fraction...
June 13, 2018: Medical Physics
https://www.readbyqxmd.com/read/29896876/estimating-the-uncertainty-of-calculated-out-of-field-organ-dose-from-a-commercial-treatment-planning-system
#19
Lilie Wang, George X Ding
Therapeutic radiation to cancer patients is accompanied by unintended radiation to organs outside the treatment field. It is known that the model-based dose algorithm has limitation in calculating the out-of-field doses. This study evaluated the out-of-field dose calculated by the Varian Eclipse treatment planning system (v.11 with AAA algorithm) in realistic treatment plans with the goal of estimating the uncertainties of calculated organ doses. Photon beam phase-space files for TrueBeam linear accelerator were provided by Varian...
June 12, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29896402/oral-metastasis-of-renal-cell-carcinoma-mimicking-recurrence-of-excised-malignant-myoepithelioma-a-case-report
#20
Yoshihiro Morita, Takaki Iwagami, Chisato Kawakita, Yukiko Kusuyama, Atsuko Niki-Yonekawa, Nobuo Morita
Following breast and lung cancers, renal cell carcinoma (RCC) is the third most frequent cancer to metastasize to the head and neck region, though such cases are rarely reported. Distinguishing between malignant tumors of salivary gland origin and metastatic RCC is very important. The case of a 75-year-old man with an oral cavity lesion in the left buccal submucosa measuring 40×30 mm that had grown substantially over several weeks is presented. His medical history included left kidney cancer 26 years earlier and a malignant myoepithelioma of the left buccal region 7 years earlier...
July 2018: Molecular and Clinical Oncology
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