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Head and neck cancer

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https://www.readbyqxmd.com/read/29656422/role-of-lactoferrin-and-lactoferrin-derived-peptides-in-oral-and-maxillofacial-diseases
#1
REVIEW
Kabilan Velliyagounder, Dania Bahdila, Siddhi Pawar, Daniel H Fine
The oral cavity harbors different taxonomic groups, the evolutionary co-existence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions that affect the host, both locally and systemically. This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities...
April 14, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29655708/salivary-flow-rate-after-conventional-and-intensity-modulated-radiation-therapy
#2
Caroline Tram Nguyen, Spencer Lin, Haley Clark, Allan Hovan, Jonn Wu
BACKGROUND: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. In this study, the authors compared the salivary flow rate in patients receiving 3DCRT and those receiving IMRT and evaluated the effect of their treatment satisfying the QUANTEC guidelines on hyposalivation...
April 11, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29653204/epha3-maintains-radioresistance-in-head-and-neck-cancers-through-epithelial-mesenchymal-transition
#3
Song Hee Kim, Won Hyeok Lee, Seong Who Kim, Je Hyoung Uk, Jong Cheol Lee, Hyo Won Chang, Young Min Kim, Kyungbin Kim, Sang Yoon Kim, Myung Woul Han
Radiotherapy is a well-established therapeutic modality used in the treatment of many cancers. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after radiation treatment. Thus, many studies have attempted to identify effective radiosensitizers. Eph receptor functions contribute to tumor development, modulating cell-cell adhesion, invasion, neo-angiogenesis, tumor growth and metastasis. However, the role of EphA3 in radioresistance remains unclear...
April 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29652817/selenium-in-radiation-oncology-15-years-of-experiences-in-germany
#4
REVIEW
Ralph Muecke, Oliver Micke, Lutz Schomburg, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz
Introduction: Se measurement and supplementation in radiation oncology is a controversial issue. The German Working Group Trace Elements and Electrolytes in Oncology (AKTE) has conducted a number of studies on this issue, which are summarized in this review. Strategies have been tested and developed, aiming to stratify the patients with a potential need for supplemental Se and how best to monitor Se supplementation with respect to health effects and risks. Methods: We analyzed blood and tissue Se-levels of different tumor patients ( n = 512)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29652014/bcl-x-expression-in-oral-cancer-comparison-between-oral-squamous-cell-carcinoma-and-verrucous-carcinoma
#5
Payal Shukla, Sudeendra Prabhu, Maji Jose, B H Sripathi Rao
Background: Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular methods, especially in tumor progression tests and Bcl-X is an important antiapoptotic member of the Bcl-2 family and is one of the newest and most useful markers to determine the aggressiveness of many carcinomas...
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29651934/effects-of-curcumin-on-squamous-cell-carcinoma-of-tongue-an-in-vitro-study
#6
Lorenzo Lo Muzio, Fatima Ardito
BACKGROUND: The squamous cell carcinoma of the tongue (TSCC) is the most frequent cancer of oral cavity often characterized by poor prognosis. Conventional therapies are not very efficient and often may cause serious side effects. In this contest, introduction of natural substances as possible adjuvant in the treatment and prevention of cancer is becoming a relevant topic. In fact, curcumin has been used for decades in Chinese traditional medicine for its beneficial effects. Curcumin has anti-cancer properties in many tumors however, its action on the tongue carcinoma is not entirely clear and many other investigations are necessary...
April 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29651597/a-two-dimensional-model-of-disrupted-body-integrity-initial-evaluation-in-head-and-neck-cancer
#7
Kenneth Mah, Sophie Lebel, Jonathan Irish, Andrea Bezjak, Ada Y M Payne, Gerald M Devins
PURPOSE: This cross-sectional study presents an initial psychometric evaluation of a two-dimensional (perceptual and evaluative) conceptualization and measure of disrupted body integrity (DBI)-illness-related disruption of the sense of the body as an integrated, smoothly functioning whole. METHODS: Male and female head and neck cancer (HNC) outpatients (N = 98) completed a questionnaire package prior to outpatient visits. MAIN OUTCOME MEASURES: The Disrupted Body Integrity Scale (DBIS) was developed to measure the perceptual and evaluative facets of DBI...
April 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29651542/the-lymphocyte-to-monocyte-ratio-as-a-prognostic-indicator-in-head-and-neck-cancer-a-systematic-review-and-meta-analysis
#8
REVIEW
Tristan Tham, Caitlin Olson, Julian Khaymovich, Saori Wendy Herman, Peter David Costantino
PURPOSE: The aim of this systematic review and meta-analysis was to investigate the relationship between the pre-treatment lymphocyte-to-monocyte ratio (LMR) and prognosis in HNC. METHODS: PubMed (via the Web), Embase, Scopus, and the Cochrane Library were searched. A systematic review and meta-analysis was done to generate the pooled hazard ratios (HR) for overall survival (OS) and disease-free survival (DFS). RESULTS: Our analysis included the results of 4260 patients in seven cohorts...
April 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29650896/-the-combination-of-molecular-targeted-agents-with-radiotherapy-in-head-and-neck-cancer
#9
Mitsuhiro Furuta, Tomoya Yokota
Concurrent cisplatin based chemoradiotherapy(CRT)is the standard of care for patients with locoregionally advanced squamous cell carcinoma of the head and neck(LA-SCCHN). Based on the Bonner trial showing the superiority of cetuximab plus radiotherapy to radiotherapy alone, cetuximab based bioradiotherapy(BRT)is considered as an alternative for patients with LA-SCCHN. However, the non-inferiority of BRT compared to CRT has not yet been demonstrated. Furthermore, severe mucositis and dermatitis induced by BRT cannot be neglected...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650894/-chemoradiotherapy-the-standard-treatment-at-present
#10
Sadamoto Zenda
Chemotherapy concurrent with radiotherapy has been widely used in clinical practice because the additional benefit on radiotherapy alone had shown. Head and neck cancer: CDDP concurrent with radiotherapy has been a standard treatment for 15years both in definitive setting and postoperative setting. Esophageal cancer: 5-FU/CDDP is the best partner for radiotherapy and appropriate radiation dose has been discussed. Anal cancer: Radical concurrent chemoradiotherapy with 5-FU and mitomycin C(MMC)remains the standard of care for squamous cell carcinoma of the anus...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650274/oral-cancer-in-fanconi-anemia-review-of-121-cases
#11
REVIEW
Camila Pinheiro Furquim, Allana Pivovar, José Miguel Amenábar, Carmem Bonfim, Cassius Carvalho Torres-Pereira
Fanconi anemia (FA) is a rare autosomal recessive genetic disorder characterized by aplastic anemia, progressive pancytopenia, congenital anomalies, and increased risk of cancer development. After hematopoietic stem cell transplant (HSCT), patients have an estimated 500-fold increase in the risk of developing head and neck cancer compared to a non-affected, and the oral cavity is affected in one-third of cases. Thus, this study aimed to better understand the natural history of oral cavity cancer in patients affected by FA...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29650060/gastrostomy-versus-nasogastric-tube-feeding-for-chemoradiation-patients-with-head-and-neck-cancer-the-tube-pilot-rct
#12
Vinidh Paleri, Joanne Patterson, Nikki Rousseau, Eoin Moloney, Dawn Craig, Dimitrios Tzelis, Nina Wilkinson, Jeremy Franks, Ann Marie Hynes, Ben Heaven, David Hamilton, Teresa Guerrero-Urbano, Rachael Donnelly, Stewart Barclay, Tim Rapley, Deborah Stocken
BACKGROUND: Approximately 9000 new cases of head and neck squamous cell cancers (HNSCCs) are treated by the NHS each year. Chemoradiation therapy (CRT) is a commonly used treatment for advanced HNSCC. Approximately 90% of patients undergoing CRT require nutritional support via gastrostomy or nasogastric tube feeding. Long-term dysphagia following CRT is a primary concern for patients. The effect of enteral feeding routes on swallowing function is not well understood, and the two feeding methods have, to date (at the time of writing), not been compared...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29649374/precision-therapy-of-head-and-neck-squamous-cell-carcinoma
#13
P J Polverini, N J D'Silva, Y L Lei
Precision medicine is an approach to disease prevention and treatment that takes into account genetic variability and environmental and lifestyle influences that are unique to each patient. It facilitates stratification of patient populations that vary in their susceptibility to disease and response to therapy. Shared databases and the implementation of new technology systems designed to advance the integration of this information will enable health care providers to more accurately predict and customize prevention and treatment strategies for patients...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29649082/transcutaneous-electrical-nerve-stimulation-reduces-resting-pain-in-head-and-neck-cancer-patients-a-randomized-and-placebo-controlled-double-blind-pilot-study
#14
Jennifer E Lee, Carryn M Anderson, Yelena Perkhounkova, Brittany M Sleeuwenhoek, Rebecca R Louison
BACKGROUND: Individuals receiving radiation for head and neck cancer (HNC) often develop painful oral mucositis that impairs function, possibly leading to feeding tubes, hospitalization, and treatment delays. Although pharmacologic medications provide some relief, many report inadequate analgesia and adverse effects. Transcutaneous electrical nerve stimulation (TENS) is a safe, nonpharmacologic intervention; it decreases pain and analgesics and improves function, yet no studies examined TENS for HNC...
April 11, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29649037/immunotherapy-in-head-and-neck-cancer-a-new-paradigm
#15
Thibaut Reverdy, Andy Karabakakian, Max Gau, Jérôme Fayette
No abstract text is available yet for this article.
June 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29648681/omip-045-characterizing-human-head-and-neck-tumors-and-cancer-cell-lines-with-mass-cytometry
#16
Tess M Brodie, Vinko Tosevski, Michaela Medová
No abstract text is available yet for this article.
April 12, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#17
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29643933/human-papillomavirus-genome-variants-and-head-and-neck-cancers-a-perspective
#18
REVIEW
Jean-Damien Combes, Silvia Franceschi
Human papillomaviruses (HPV) cause infections that are responsible for diverse clinical manifestations from benign conditions to invasive cancer. As different HPV types are associated with variable pathogenic potential, minor genetic variations within a given high-risk HPV type might also be associated with distinct oncogenic capacities, through variable ability of persistence or risk of progression to precancer/cancer. Most recent HPV variant studies in the cervix using latest sequencing technology confirmed that minor changes in the HPV genome can have a major influence on carcinogenesis and have revealed key data that help better understand the carcinogenicity of HPV at a molecular level...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29643063/evaluation-of-prexasertib-a-checkpoint-kinase-1-inhibitor-in-a-phase-ib-study-of-patients-with-squamous-cell-carcinoma
#19
David S Hong, Kathleen N Moore, Manish R Patel, Stefan C Grant, Howard A Burris, William N William, Suzanne Jones, Funda Meric-Bernstam, Jeffrey Infante, Lisa Golden, Wei Zhang, Ricardo Martinez, Sameera R Wijayawardana, Richard P Beckmann, Aimee Bence Lin, Cathy Eng, Johanna C Bendell
PURPOSE: Prexasertib, a checkpoint kinase 1 inhibitor, demonstrated single-agent activity in patients with advanced squamous cell carcinoma (SCC) in the dose-escalation portion of a Phase I study (NCT01115790). Monotherapy prexasertib was further evaluated in patients with advanced SCC. EXPERIMENTAL DESIGN: Patients were given prexasertib 105 mg/m2 as a 1-hour infusion on day 1 of a 14-day cycle. Expansion cohorts were defined by tumor and treatment line. Safety, tolerability, efficacy, and exploratory biomarkers were analyzed...
April 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29642437/photodynamic-effect-of-methylene-blue-and-low-level-laser-radiation-in-head-and-neck-squamous-cell-carcinoma-cell-lines
#20
Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas
Photodynamic therapy (PDT) is suggested to have an impact on the treatment of early stage head and neck cancers (HNSCC). We investigated the effect of PDT with methylene blue (MB) and a diode laser (660 nm) as the laser source on HNSCC cell lines as an in vitro model of surface oral squamous cell carcinoma. Cell-cultures were exposed to 160 µM MB for 4 min and to laser light for 8 min. Viability was proven via cell viability assay and clonogenic survival via clone counting assay. The combination of MB and diode laser evidenced high efficient loss of cell viability by 5% of the control, while treatment with the same concentration of MB for 4 min alone showed a viability of 46% of the control...
April 7, 2018: International Journal of Molecular Sciences
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