keyword
https://read.qxmd.com/read/38536913/cardiac-tissue-model-of-immune-induced-dysfunction-reveals-the-role-of-free-mitochondrial-dna-and-the-therapeutic-effects-of-exosomes
#1
JOURNAL ARTICLE
Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T Wagner, Erika L Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C Andreazza, Claudia C Dos Santos, Milica Radisic
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute myocarditis. We observed hallmarks of coronavirus disease (COVID-19)-induced myocardial inflammation, as the presence of immune cells augmented the secretion of proinflammatory cytokines, triggered progressive impairment of contractile function, and altered intracellular calcium transients...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38534778/genetic-and-environmental-factors-in-autoimmune-thyroid-disease-exploring-associations-with-selenium-levels-and-novel-loci-in-a-latvian-cohort
#2
JOURNAL ARTICLE
Sabine Upmale-Engela, Ieva Vaivode, Raitis Peculis, Helena Litvina, Tatjana Zake, Andrejs Skesters, Deniss Gogins, Vita Rovite, Ilze Konrade
The interplay of genetic, immune and environmental factors strongly contributes to the development of autoimmune thyroid disease (AITD), which can be classified as Graves' disease (GD) or Hashimoto thyroiditis (HT). One of the most studied exogenous factors in the pathogenesis of AITD is selenium, which, in the form of selenoproteins, strengthens the antioxidative defence system of thyroid cells against superoxide production. Furthermore, it modulates inflammatory cytokine release and autoantibody production...
March 17, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534772/5-aza-upregulates-socs3-and-ptpn6-shp1-inhibiting-stat3-and-potentiating-the-effects-of-ag490-against-primary-effusion-lymphoma-cells
#3
JOURNAL ARTICLE
Michele Di Crosta, Andrea Arena, Rossella Benedetti, Maria Saveria Gilardini Montani, Mara Cirone
Epigenetic modifications, including aberrant DNA methylation occurring at the promoters of oncogenes and oncosuppressor genes and histone modifications, can contribute to carcinogenesis. Aberrant methylation mediated by histone methylatransferases, alongside histones, can affect methylation of proteins involved in the regulation of pro-survival pathways such as JAK/STAT and contribute to their activation. In this study, we used DNA or histone demethylating agents, 5-Azacytidine (5-AZA) or DS-3201 (valemetostat), respectively, to treat primary effusion lymphoma (PEL) cells, alone or in combination with AG490, a Signal transducer and activator of transcription 3 (STAT3) inhibitor...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534758/autophagy-dependent-secretion-crosstalk-between-autophagy-and-exosome-biogenesis
#4
REVIEW
Ekaterina Zubkova, Alexander Kalinin, Anastasya Bolotskaya, Irina Beloglazova, Mikhail Menshikov
The cellular secretome is pivotal in mediating intercellular communication and coordinating responses to stressors. Exosomes, initially recognized for their role in waste disposal, have now emerged as key intercellular messengers with significant therapeutic and diagnostic potential. Similarly, autophagy has transcended its traditional role as a waste removal mechanism, emerging as a regulator of intracellular communication pathways and a contributor to a unique autophagy-dependent secretome. Secretory authophagy, initiated by various stress stimuli, prompts the selective release of proteins implicated in inflammation, including leaderless proteins that bypass the conventional endoplasmic reticulum-Golgi secretory pathway...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534390/comparison-of-minced-cartilage-implantation-with-autologous-chondrocyte-transplantation-in-an-in-vitro-inflammation-model
#5
JOURNAL ARTICLE
Robert Ossendorff, Lisa Grede, Sebastian Scheidt, Andreas C Strauss, Christof Burger, Dieter C Wirtz, Gian M Salzmann, Frank A Schildberg
The current gold standard to treat large cartilage defects is autologous chondrocyte transplantation (ACT). As a new surgical method of cartilage regeneration, minced cartilage implantation (MCI) is increasingly coming into focus. The aim of this study is to investigate the influence of chondrogenesis between isolated and cultured chondrocytes compared to cartilage chips in a standardized inflammation model with the proinflammatory cytokine TNFα. Articular chondrocytes from bovine cartilage were cultured according to the ACT method to passage 3 and transferred to spheroid culture...
March 20, 2024: Cells
https://read.qxmd.com/read/38534377/granular-insights-neutrophil-predominance-and-elastase-release-in-severe-asthma-exacerbations-in-a-pediatric-cohort
#6
JOURNAL ARTICLE
Kirstin Henley, Erin Tresselt, Jessica S Hook, Parth A Patel, Michelle A Gill, Jessica G Moreland
The chronic inflammatory component of asthma is propagated by granulocytes, including neutrophils and eosinophils, in the peripheral circulation and airway. Previous studies have suggested that these cells have an altered expression of adhesion-related molecules and a propensity for the release of granule contents that may contribute to tissue damage and enhance inflammatory complications in patients with status asthmaticus. The goal of this prospective cohort study at a tertiary care pediatric hospital with a large population of asthma patients was to assess the role of granulocyte-based inflammation in the development of asthma exacerbation...
March 18, 2024: Cells
https://read.qxmd.com/read/38534355/recent-research-trends-in-neuroinflammatory-and-neurodegenerative-disorders
#7
REVIEW
Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins...
March 14, 2024: Cells
https://read.qxmd.com/read/38534312/synthetic-biology-meets-ca-2-release-activated-ca-2-channel-dependent-immunomodulation
#8
REVIEW
Bernadett Bacsa, Valentina Hopl, Isabella Derler
Many essential biological processes are triggered by the proximity of molecules. Meanwhile, diverse approaches in synthetic biology, such as new biological parts or engineered cells, have opened up avenues to precisely control the proximity of molecules and eventually downstream signaling processes. This also applies to a main Ca2+ entry pathway into the cell, the so-called Ca2+ release-activated Ca2+ (CRAC) channel. CRAC channels are among other channels are essential in the immune response and are activated by receptor-ligand binding at the cell membrane...
March 7, 2024: Cells
https://read.qxmd.com/read/38534054/successful-treatment-of-refractory-orbital-plasmacytoma-with-chimeric-antigen-receptor-t-cell-therapy-a-case-report-and-review-of-the-literature
#9
JOURNAL ARTICLE
Rebecca Z Lin, Tracy Lu, Natalie Homer, Clara J Men
Orbital plasmacytoma is a rare plasma cell tumor that may arise as an aggressive form of extramedullary multiple myeloma. Treatment modalities include surgical excision, radiation, and chemotherapy. Chimeric antigen receptor T cell therapy is currently reserved for refractory disease. The authors present a case of a 69-year-old woman with an extensive orbital plasmacytoma refractory to multimodal therapy who was treated with idecabtagene vicleucel chimeric antigen receptor T cell therapy. Four days after infusion, the patient exhibited grade 1 cytokine release syndrome, which resolved with tocilizumab...
March 21, 2024: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38533646/novel-bispecific-nanobody-mitigates-experimental-intestinal-inflammation-in-mice-by-targeting-tnf-%C3%AE-and-il-23p19-bioactivities
#10
JOURNAL ARTICLE
Jiewen Wang, Guangbo Kang, Huiying Lu, Ario de Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, Yuli Wang, Miao Zhang, Ping Wang, Yuanhang Feng, Zhanju Liu, Xiaocang Cao, He Huang
BACKGROUND: Inflammatory bowel diseases (IBDs) pose significant challenges in terms of treatment non-response, necessitating the development of novel therapeutic approaches. Although biological medicines that target TNF-α (tumour necrosis factor-α) have shown clinical success in some IBD patients, a substantial proportion still fails to respond. METHODS: We designed bispecific nanobodies (BsNbs) with the ability to simultaneously target human macrophage-expressed membrane TNF-α (hmTNF-α) and IL-23...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38533538/cxcr4-targeted-macrophage-derived-biomimetic-hybrid-vesicle-nanoplatform-for-enhanced-cancer-therapy-through-codelivery-of-manganese-and-doxorubicin
#11
JOURNAL ARTICLE
Yeonwoo Jang, Young Seok Cho, April Kim, Xingwu Zhou, Yujin Kim, Ziye Wan, James J Moon, Hansoo Park
Immune-cell-derived membranes have garnered significant attention as innovative delivery modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and superior biocompatibilities. Integrating additional parental cell membranes or synthetic lipid vesicles into cellular vesicles can further potentiate their capacities to perform combinatorial pharmacological activities in activating antitumor immunity, thus providing insights into the potential of hybrid cellular vesicles as versatile delivery vehicles for cancer immunotherapy...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38533037/dexmedetomidine-suppressed-the-biological-behavior-of-raw264-7-cells-treated-with-lps-by-down-regulating-hotair
#12
JOURNAL ARTICLE
Qin Liu, Guang-Hu Yang, Nai-Zhi Wang, Xin-Cheng Wang, Zhao-Long Zhang, Lu-Jun Qiao, Wen-Juan Cui
BACKGROUND: Previous studies have revealed dexmedetomidine have potential protective effects on vital organs by inhibiting the release of inflammatory cytokines. To investigate the effects of dexmedetomidine on sepsis, especially in the initial inflammatory stage of sepsis. RAW264.7 cells were used as the cell model in this study to elucidate the underlying mechanisms. METHODS: In this study, we conducted several assays to investigate the mechanisms of dexmedetomidine and HOTAIR in sepsis...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532906/enhanced-postsurgical-cancer-treatment-using-methacrylated-glycol-chitosan-hydrogel-for-sustained-dna-doxorubicin-delivery-and-immunotherapy
#13
JOURNAL ARTICLE
Hee Seung Seo, Jun-Hyeok Han, Jaesung Lim, Ga-Hyun Bae, Min Ji Byun, Chi-Pin James Wang, Jieun Han, Juwon Park, Hee Ho Park, Mikyung Shin, Tae-Eun Park, Tae-Hyung Kim, Se-Na Kim, Wooram Park, Chun Gwon Park
Background: Cancer recurrence and metastasis are major contributors to treatment failure following tumor resection surgery. We developed a novel implantable drug delivery system utilizing glycol chitosan to address these issues. Glycol chitosan is a natural adjuvant, inducing dendritic cell activation to promote T helper 1 cell immune responses, macrophage activation, and cytokine production. Effective antigen production by dendritic cells initiates T-cell-mediated immune responses, aiding tumor growth control...
2024: Biomaterials Research
https://read.qxmd.com/read/38532628/in-vitro-and-in-vivo-validation-of-the-antiviral-effect-of-hcypa-against-sars-cov-2-via-binding-to-the-rbd-of-spike-protein
#14
JOURNAL ARTICLE
Woo-Ri Shin, Do-Young Kim, Sang Yong Kim, Gna Ahn, Dae-Young Park, Jiho Min, Ji-Young Ahn, Yang-Hoon Kim
The novel coronavirus disease 2019 has stimulated the rapid development of new biological therapeutics to inhibit SARS-CoV-2 infection; however, this remains a challenging task. In a previous study using structural analysis, we revealed that human cyclophilin A inhibits the entry of SARS-CoV-2 into host cells by interfering with the interaction of the receptor-binding domain of the spike protein with angiotensin-converting enzyme 2 on the host cell surface, highlighting its potential for antiviral therapy. For a comprehensive experimental validation, in this study, we verified the antiviral effects of human cyclophilin A against SARS-CoV-2, including its variants, using in vitro assays and experiments on an in vivo mouse model...
March 25, 2024: Molecular Therapy
https://read.qxmd.com/read/38532626/increased-vesicular-dynamics-and-nanoscale-clustering-of-il-2-after-t-cell-activation
#15
JOURNAL ARTICLE
Badeia Saed, Neal T Ramseier, Thilini Perera, Jesse Anderson, Jacob Burnett, Hirushi Gunasekara, Alyssa Burgess, Haoran Jing, Ying S Hu
T cells coordinate intercellular communication through the meticulous regulation of cytokine secretion. Direct visualization of vesicular transport and intracellular distribution of cytokines provides valuable insights into the temporal and spatial mechanisms involved in regulation. Employing Jurkat E6-1 T cells and interleukin-2 (IL-2) as a model system, we investigated vesicular dynamics using single-particle tracking and the nanoscale distribution of intracellular IL-2 in fixed T cells using superresolution microscopy...
March 26, 2024: Biophysical Journal
https://read.qxmd.com/read/38532515/inflammation-and-acute-cardiotoxicity-in-adult-hematological-patients-treated-with-car-t-cells-results-from-a-pilot-proof-of-concept-study
#16
JOURNAL ARTICLE
Massimiliano Camilli, Marcello Viscovo, Tamara Felici, Luca Maggio, Federico Ballacci, Giacomo Carella, Alice Bonanni, Priscilla Lamendola, Lorenzo Tinti, Antonio Di Renzo, Giulia Coarelli, Eugenio Galli, Giovanna Liuzzo, Francesco Burzotta, Rocco Antonio Montone, Federica Sorà, Simona Sica, Stefan Hohaus, Gaetano Antonio Lanza, Filippo Crea, Antonella Lombardo, Giorgio Minotti
AIMS: Chimeric Antigen Receptor-T (CAR-T) cell infusion is a rapidly evolving antitumor therapy; however, cardiovascular (CV) complications, likely associated with cytokine release syndrome (CRS) and systemic inflammation, have been reported to occur. The CARdio-Tox study aimed at elucidating incidence and determinants of cardiotoxicity related to CAR-T cell therapy. METHODS: Patients with blood malignancies candidate to CAR-T cells were prospectively evaluated by echocardiography at baseline and 7 and 30 days after infusion...
March 27, 2024: Cardio-Oncology
https://read.qxmd.com/read/38531477/sports-and-immunity-from-the-recreational-to-the-elite-athlete
#17
REVIEW
Richard Baskerville, Linda Castell, Stéphane François Bermon
The pivotal role of the immune system in physical activity is well-established. While interactions are complex, they tend to constitute discrete immune responses. Moderate intensity exercise causes leukocytosis with a mild anti-inflammatory cytokine profile and immunoenhancement. Above a threshold of intensity, lactate-mediated IL-6 release causes a proinflammatory followed by a depressed inflammatory state, which stimulates immune adaptation and longer term cardiometabolic enhancement. Exercise-related immune responses are modulated by sex, age and immune-nutrition...
March 24, 2024: Infectious diseases now
https://read.qxmd.com/read/38531065/evidence-that-keratinocyte-microvesicle-particles-carrying-platelet-activating-factor-mediate-the-widespread-multi-organ-damage-associated-with-intoxicated-thermal-burn-injury
#18
JOURNAL ARTICLE
Rushabh P Lohade, Chad Brewer, Christine M Rapp, Karen M Henkels, Wenfeng Zhang, Anita Thyagarajan, Shikshita Singh, Pranali Manjrekar, Taskin Sabit, Ravi P Sahu, Jeffrey B Travers
Thermal burn injuries can result in significant morbidity and mortality. The combination of ethanol intoxication with thermal burn injury results in increased morbidity through an exaggerated inflammatory response involving many organs. Recent studies have linked involvement of the lipid mediator Platelet-activating factor (PAF) in the pathology associated with intoxicated thermal burn injury (ITBI). The present studies tested the roles of PAF and the elevated levels of subcellular microvesicle particles (MVP) generated in response to ITBI in the subsequent multi-organ toxicity...
March 26, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38530532/anti-inflammatory-potential-of-simvastatin-and-amfenac-in-arpe-19-cells-insights-in-preventing-re-detachment-and-proliferative-vitreoretinopathy-after-rhegmatogenous-retinal-detachment-surgery
#19
JOURNAL ARTICLE
Niina Harju, Maria Hytti, Onni Kolari, Hilkka Nisula, Sirpa Loukovaara, Anu Kauppinen
PURPOSE: Rhegmatogenous retinal detachment is a severe vision-threatening complication that can result into proliferative vitreoretinopathy (PVR) and re-detachment of the retina if recovery from surgery fails. Inflammation and changes in retinal pigment epithelial (RPE) cells are important contributors to the disease. Here, we studied the effects of simvastatin and amfenac on ARPE-19 cells under inflammatory conditions. METHODS: ARPE-19 cells were pre-treated with simvastatin and/or amfenac for 24 h after which interleukin (IL)-1α or IL-1β was added for another 24 h...
March 26, 2024: International Ophthalmology
https://read.qxmd.com/read/38529844/a-whole-course-repair-system-based-on-ros-glucose-stimuli-responsive-egcg-release-and-tunable-mechanical-property-for-efficient-treatment-of-chronic-periodontitis-in-diabetic-rats
#20
JOURNAL ARTICLE
Qingchen Feng, Mei Zhang, Guanning Zhang, Hongxiang Mei, Chongying Su, Lisa Liu, Xiaoxia Wang, Ziqianhong Wan, Zhengyi Xu, Liangkui Hu, Yu Nie, Juan Li
Elevated glucose levels, multiple pro-inflammatory cytokines and the generation of excessive reactive oxygen species (ROS) are pivotal characteristics within the microenvironments of chronic periodontitis with diabetes mellitus (CPDM). Control of inflammation and modulation of immune system are required in the initial phase of CPDM treatment, while late severe periodontitis requires a suitable scaffold to promote osteogenesis, rebuild periodontal tissue and reduce alveolar bone resorption. Herein, a whole-course-repair system is introduced by an injectable hydrogel using phenylboronic acid functionalized oxidized sodium alginate (OSA-PBA) and carboxymethyl chitosan (CMC)...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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