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https://www.readbyqxmd.com/read/28109168/integrated-omics-analysis-of-specialized-metabolism-in-medicinal-plants
#1
Amit Rai, Kazuki Saito, Mami Yamazaki
Medicinal plants are the rich source of highly diverse specialized metabolites with important pharmacological properties. Until recently, plant biologists were limited in their approach to explore biosynthetic pathways of these metabolites, mainly due to the scarcity of plant genomics resources. Recent advancements in the high-throughput large-scale analytical methods have enabled plant biologists to discover biosynthetic pathways for important plant-based medicinal metabolites. Reduced cost to generate omics datasets, and the development of computational tools for their analysis and integration have led to the elucidation of biosynthetic pathways of several plant origin bio-active metabolites...
January 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28109136/therapeutic-potential-of-targeting-wnt-%C3%AE-catenin-pathway-in-treatment-of-colorectal-cancer-rational-and-progress
#2
Afsane Bahrami, Forouzan Amerizadeh, Soodabeh ShahidSales, Majid Khazaei, Majid Ghayour-Mobarhan, Hamid Reza Sadeghnia, Mina Maftouh, Seyed Mahdi Hassanian, Amir Avan
Wnt/β-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant activation of this pathway is associated with cell proliferation, invasive behaviors and cell resistance, suggesting its potential value as a therapeutic target in treatment of CRC. Several agents have been developed for targeting of this pathway (e.g, natural agents: curcumin, 3,3-diindolylmethane, phytoestrogen; Synthetic/small Wnt inhibitors: Rofecoxib; PRI-724, CWP232291; and monoclonal antibody against frizzled receptors, Vanituctumab...
January 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28109081/shope-fibroma-in-the-external-ear-canal-of-a-domestic-rabbit
#3
Shawna J
A 5-y-old, intact, 2.5-kg female domestic rabbit was presented because of blood spatter on the wall of its cage and thetoenailsof its right hind limb. Physical examination revealed a red, gelatinous mass that spanned the width of the right vertical ear canal. Radiographic images revealed a soft-tissue opacity at the base of the right ear, which was superimposed over the tympanic bulla and extended to the pinna. A CT scan revealed that the soft-tissue mass was within the vertical and horizontal portions of the right external ear canal and extended to the level of the tympanic membrane, with no bony involvement...
January 20, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28109053/frogs-model-man-in-vivo-thyroid-hormone-signaling-during-development
#4
REVIEW
Laurent M Sachs, Daniel R Buchholz
Thyroid hormone (TH) signaling comprises TH transport across cell membranes, metabolism by deiodinases, and molecular mechanisms of gene regulation. Proper TH signaling is essential for normal perinatal development, most notably for neurogenesis and fetal growth. Knowledge of perinatal TH endocrinology needs improvement to provide better treatments for premature infants and endocrine diseases during gestation and to counteract effects of endocrine disrupting chemicals. Studies in amphibians have provided major insights to understand in-vivo mechanisms of TH signaling...
January 21, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28109035/competitive-benzyl-cation-transfer-proton-transfer-collision-induced-mass-spectrometric-fragmentation-of-protonated-n-n-dibenzylaniline
#5
Ge Ma, Gongye Liu, Shanshan Shen, Yunfeng Chai, Lei Yue, Shunping Zhao, Yuanjiang Pan
Collision-induced dissociation of protonated N,N-dibenzylaniline was investigated by electrospray tandem mass spectrometry. Various fragmentation pathways were dominated by benzyl cation and proton transfer. Benzyl cation transfers from the initial site (nitrogen) to benzylic phenyl or aniline phenyl ring. The benzyl cations transfer to the two different sites and both result in the benzene loss combined with 1,3-H shift. In addition, after the benzyl cation transfers to the benzylic phenyl ring, 1,2-H shift and 1,4-H shift proceed competitively to trigger the diphenylmethane loss and aniline loss respectively...
January 21, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28109007/retinoic-acid-inducible-gene-i-rig-i-like-receptors-rlrs-in-fish-current-knowledge-and-future-perspectives
#6
REVIEW
Shan Nan Chen, Peng Fei Zou, Pin Nie
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are found conservatively present in teleost fish. All three members, RIG-I, MDA5 and LGP2 together with the downstream molecules such as MITA, TRAF3 and TBK1 have been identified in a range of fish species. However, it is a bit unexpected that RIG-I has not been reported in fish of Acanthopterygii, and it would be important to clarify the presence and role of RIG-I gene in a broad range of taxa in Teleostei. RLRs in fish can be induced in vivo and in vitro by viral pathogens as well as synthetic double-stranded RNA (dsRNA), poly(I:C), leading to the production of type I IFNs and the expression of IFN stimulated genes (ISGs)...
January 20, 2017: Immunology
https://www.readbyqxmd.com/read/28108955/-unforgettable-a-pictorial-essay-on-anatomy-and-pathology-of-the-hippocampus
#7
REVIEW
Sven Dekeyzer, Isabelle De Kock, Omid Nikoubashman, Stephanie Vanden Bossche, Ruth Van Eetvelde, Jeroen De Groote, Marjan Acou, Martin Wiesmann, Karel Deblaere, Eric Achten
: The hippocampus is a small but complex anatomical structure that plays an important role in spatial and episodic memory. The hippocampus can be affected by a wide range of congenital variants and degenerative, inflammatory, vascular, tumoral and toxic-metabolic pathologies. Magnetic resonance imaging is the preferred imaging technique for evaluating the hippocampus. The main indications requiring tailored imaging sequences of the hippocampus are medically refractory epilepsy and dementia...
January 20, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28108879/patterns-of-social-affiliations-and-healthcare-engagement-among-young-black-men-who-have-sex-with-men
#8
Rachel L Behler, Benjamin T Cornwell, John A Schneider
Little work has examined how individuals' social affiliations-the venues in which they meet friends and engage in informal social interaction-influence their engagement with public health services. We investigate how links to these local places shape access to information and exposure to health-seeking behavior. Using longitudinal data from a respondent-driven sample of 618 young black men who have sex with men (YBMSM) in Chicago, we identify different sets of social venues that connect YBMSM. We then examine how YBMSM's connections within this network influence their receipt of HIV prevention and treatment services and knowledge of pre-exposure prophylaxis (PrEP)...
January 21, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28108863/genetic-and-environmental-structure-of-dsm-iv-criteria-for-antisocial-personality-disorder-a-twin-study
#9
Tom Rosenström, Eivind Ystrom, Fartein Ask Torvik, Nikolai Olavi Czajkowski, Nathan A Gillespie, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Ted Reichborn-Kjennerud
Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level...
January 21, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28108853/brain-metastasis-of-carcinoma-ex-pleomorphic-adenoma-of-the-parotid-gland-case-report-and-review-of-the-literature
#10
Ruth Lau, Alejandro Fernández-Coello, Noemí Vidal-Sarró, Dennis Céspedes, Angels Camins, Miren Taberna, Andreu Gabarrós
We present an extremely infrequent case of brain metastasis of a parotid tumor. To our knowledge, this is the second case reported of a brain metastasis of a malignant parotid tumor, carcinoma ex pleomorphic adenoma. Pleomorphic adenoma represents 60% of tumors of the parotid gland, and although it is a benign tumor, it can transform into carcinoma ex pleomorphic adenoma in 5% of cases, one of the most aggressive neoplasms of the salivary glands. We want to note the need for an accurate diagnostic. Thanks to aggressive surgical management, our patient survived more than 1½ years...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28108846/knowledge-attitudes-practices-and-barriers-related-to-research-utilization-a-survey-among-pharmacists-in-malaysia
#11
Sin Yee Tan, Ernieda Hatah
Background Research utilization is part of evidence-based practice referring to the process of reviewing and critiquing scientific research and applying the findings to one's own clinical practice. Many studies on research utilization have been conducted with doctors and nurses, but to our knowledge, none have been investigated amongst pharmacists. Objective To assess research utilization and its barriers among pharmacists and identify potential influencing factors. Setting Malaysia. Methods This cross-sectional survey was administered online and by mail to a convenient sample of pharmacists working in hospitals, health clinics, and retail pharmacies in rural and urban areas...
January 20, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28108835/integrating-family-as-a-discipline-by-providing-parent-led-curricula-impact-on-lend-trainees-leadership-competency
#12
Bruce L Keisling, Elizabeth A Bishop, Jenness M Roth
Background While the MCH Leadership Competencies and family as a discipline have been required elements of Leadership Education in Neurodevelopmental and related Disabilities (LEND) programs for over a decade, little research has been published on the efficacy of either programmatic component in the development of the next generation of leaders who can advocate and care for Maternal and Child Health (MCH) populations. Objective To test the effectiveness of integrating the family discipline through implementation of parent led curricula on trainees' content knowledge, skills, and leadership development in family-centered care, according to the MCH Leadership Competencies...
January 20, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28108811/who-really-wins-efficacy-of-a-croatian-youth-gambling-prevention-program
#13
Aleksandra Huic, Valentina Kranzelic, Dora Dodig Hundric, Neven Ricijas
This paper reports on the development and pilot evaluation of a Croatian school-based youth gambling prevention program "Who really wins?". The program is aimed at minimizing risk and enhancing protective factors related to youth gambling. A short-term evaluation of the program was conducted with a sample of 190 first and second year high-school students (67.6% boys, aged 14-17 years; average age 15.61). An experimental design with two groups (Training vs. No Training) and two measurement sessions (pre-test and post-test sessions) was used to evaluate change in problem gambling awareness, cognitive distortions, knowledge of the nature of random events as well as in social skills...
January 20, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28108771/-injuries-of-major-tendons-review-of-current-diagnostic-and-surgical-standards
#14
P Behrendt, T Klüter, A Seekamp
Chronic degenerative tendon injuries as well as injuries due to acute high-energy trauma and incisional injuries are a significant aspect in the emergency surgery department. As a result of anatomical characteristics and exposure certain tendons are particularly vulnerable to injury. These include the biceps brachialis, quadriceps femoris, patella, achilles and tibialis anterior tendons. Besides the broad spectrum of non-surgical treatment, surgeons should have knowledge of the various surgical techniques including suturing, anchor refixation and reconstruction techniques...
January 20, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28108765/score-study-quality-indicators-for-rheumatology-nursing-clinics
#15
Santiago Muñoz-Fernández, Ma Dolores Aguilar, Raquel Almodóvar, Laura Cano-García, Sandra Fortea, Cristina Patricia Alcañiz-Escandell, José R Rodríguez, Laura Cebrián, Pablo Lázaro
Nursing clinics in rheumatology (NCR) are organizational care models that provide care centred within the scope of nurses abilities. To analyse patients differences in the knowledge of the disease, adherence to the treatment, quality indicators of the Rheumatology Departments included quality perceived by the patients with and without NCR. National multicenter observational prospective cohort study 1 year follow-up, comparing patients attending rheumatology services with and without NCR. NCR was defined by the presence of: (1) office itself; (2) at least one dedicated nurse; (3) its own appointment schedule, and (4) phone...
January 20, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28108685/a-tablet-based-multimedia-education-tool-improves-provider-and-subject-knowledge-of-inhaler-use-techniques
#16
Aaron M Mulhall, Muhammad A Zafar, Samantha Record, Herman Channell, Ralph J Panos
BACKGROUND: Although inhaled medications are effective therapies for COPD, many patients and providers use them incorrectly. METHODS: We recruited providers who prescribe inhalers or teach inhaler technique and assessed their use of metered-dose inhalers (MDIs), various dry powder inhalers (DPIs), and Respimat using predefined checklists. Then they watched tablet-based multimedia educational videos that demonstrated correct inhaler technique by a clinical pharmacist with teach-back from a patient and were re-evaluated...
February 2017: Respiratory Care
https://www.readbyqxmd.com/read/28108554/genome-wide-analysis-of-lncrna-and-mrna-expression-during-differentiation-of-abdominal-preadipocytes-in-the-chicken
#17
Tao Zhang, Xiangqian Zhang, Kunpeng Han, Genxi Zhang, Jinyu Wang, Kaizhou Xie, Qian Xue
Long non-coding RNAs (lncRNAs) regulate adipogenesis and other processes associated with metabolic tissue development and function. However, little is known about the function and profile of lncRNAs during preadipocyte differentiation in the chicken (Gallus gallus). Herein, lncRNA and mRNA expression in preadipocytes at different stages of differentiation were analyzed using RNA sequencing. A total of 1,300,074,528 clean reads and 27,023 novel lncRNAs were obtained from 12 samples. The number of genes (1,336 lncRNAs and 1,759 mRNAs; 3,095 in total) differentially expressed across various stages declined as differentiation progressed...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28108525/back-to-the-roots-of-regulated-necrosis
#18
Vladimir Todorov, Andreas Linkermann
In recent years, our knowledge of how cells die by regulated pathways of necrosis has increased tremendously. In this issue, Distéfano et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605110) provide yet another milestone in our understanding of regulated necrosis as they identify a ferroptosis-like cell death in Arabidopsis thaliana.
January 20, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28108495/neural-representations-of-belief-concepts-a-representational-similarity-approach-to-social-semantics
#19
Anna Leshinskaya, Juan Manuel Contreras, Alfonso Caramazza, Jason P Mitchell
The present experiment identified neural regions that represent a class of concepts that are independent of perceptual or sensory attributes. During functional magnetic resonance imaging scanning, participants viewed names of social groups (e.g. Atheists, Evangelicals, and Economists) and performed a one-back similarity judgment according to 1 of 2 dimensions of belief attributes: political orientation (Liberal to Conservative) or spiritualism (Spiritualist to Materialist). By generalizing across a wide variety of social groups that possess these beliefs, these attribute concepts did not coincide with any specific sensory quality, allowing us to target conceptual, rather than perceptual, representations...
January 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28108476/dynamic-analysis-of-the-mesenchymal-epithelial-transition-of-blood-brain-barrier-forming-glia-in-drosophila
#20
Tina Schwabe, Xiaoling Li, Ulrike Gaul
During development, many epithelia are formed by a mesenchymal-epithelial transition (MET). Here, we examine the major stages and underlying mechanisms of MET during blood-brain barrier formation in Drosophila We show that contact with the basal lamina is essential for the growth of the barrier-forming subperineurial glia (SPG). Septate junctions (SJs), which provide insulation of the paracellular space, are not required for MET, but are necessary for the establishment of polarized SPG membrane compartments...
January 20, 2017: Biology Open
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