keyword
MENU ▼
Read by QxMD icon Read
search

KNOWLEDGE

keyword
https://www.readbyqxmd.com/read/29150992/accelerated-aging-and-aging-process-in-the-brain
#1
Nickolay K Isaev, Elisaveta E Genrikhs, Maria V Oborina, Elena V Stelmashook
One of the approaches to the research of the problem of aging is the study of genetic pathologies leading to accelerated aging, such as the Hutchinson-Gilford progeria syndrome, Werner syndrome, and Down syndrome. Probably, this approach can be used in an attempt to understand the neuronal mechanisms underlying normal and pathological brain aging. The analysis of the current state of scientific knowledge about these pathologies shows that in the Hutchinson-Gilford progeria and Werner syndrome, the rate of brain aging is significantly lower than the rate of whole body aging, whereas in Down syndrome, the brain ages faster than other organs due to amyloid-beta accumulation and chronic oxidative stress in the brain tissue...
November 18, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29150944/toll-like-receptor-signaling-pathway-as-a-potential-therapeutic-target-in-colorectal-cancer
#2
REVIEW
Reyhaneh Moradi-Marjaneh, Seyed Mahdi Hassanian, Hamid Fiuji, Saman Soleimanpour, Gordon A Ferns, Amir Avan, Majid Khazaei
Toll like receptor (TLR) signaling is involved in activating innate and adaptive immune responses and plays a critical role in inflammation-induced diseases such as colorectal cancer (CRC). Dysregulation of this signaling pathway can result in disturbance of epithelial layer hemostasis, chronic inflammatory, excessive repair responses and development of CRC. There is now substantial evidence for the benefit of targeting of this pathway in cancer treatment, and several agents have been approved, such as BCG (Bacillus Calmette Guérin), MPL (monophosphoryl lipid A) and imiquimod...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150921/tgf-%C3%AE-and-hepatocellular-carcinoma-when-a-friend-becomes-an-enemy
#3
Marco Arrese, Daniel Cabrera, Alejandra Hernandez, Luis Astete, Lisbell Estrada, Claudio Cabello-Verrugio
Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide accounting for more than 700 thousand deaths per year. Most of the HCC develops in a cirrhotic liver, a microenvironment where fibrotic tissue replaces parenchymal cells. Thus, there is a close connection between fibrosis and HCC development. Understanding the cellular and molecular mechanisms involved in this process is a crucial step to advance in novel therapeutic or pharmacological strategies to prevent or improve the course of this malignancy...
November 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29150917/regulation-of-mesenchymal-stem-cell-differentiation-by-transforming-growth-factor-beta-superfamily
#4
Jelena Krstic, Drenka Trivanovic, Hristina Obradovic, Tamara Kukolj, Diana Bugarski, Juan F Santibanez
The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-β) superfamily directs MSCs commitment in the selection of differentiation pathways...
November 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29150910/educating-youth-swine-exhibitors-on-influenza-a-virus-transmission-at-agricultural-fairs
#5
J M Nolting, J Midla, M S Whittington, S D Scheer, A S Bowman
Influenza A virus (IAV) is a major zoonotic pathogen that threatens global public health. Novel strains of influenza A viruses pose a significant risk to public health due to their pandemic potential, and transmission of influenza A viruses from animals to humans is an important mechanism in the generation and introduction of IAVs that threaten human health. The purpose of this descriptive correlational study was to develop real-life training scenarios to better inform swine exhibitors of the risks they may encounter when influenza A viruses are present in swine...
November 17, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29150876/toxicological-characterization-of-zno-nanoparticles-in-malignant-and-non-malignant-cells
#6
Helena Moratin, Agmal Scherzad, Thomas Gehrke, Pascal Ickrath, Katrin Radeloff, Norbert Kleinsasser, Stephan Hackenberg
The increasing usage of zinc oxide nanoparticles (ZnO-NPs) in industrial applications as well as in consumer products raises concern regarding their potential adverse effects to a greater extend. Numerous studies have demonstrated toxic properties of NPs, however there is still a lack of knowledge concerning the underlying mechanisms. This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO-NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non-malignant cells...
November 18, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29150848/allergen-manufacturing-and-quality-aspects-for-allergen-immunotherapy-in-europe-and-the-united-states-an-analysis-from-the-eaaci-ait-guidelines-project
#7
REVIEW
A Bonertz, G Roberts, J E Slater, J Bridgewater, R L Rabin, M Hoefnagel, M Timon, C Pini, O Pfaar, A Sheikh, D Ryan, C Akdis, J Goldstein, L K Poulsen, R van Ree, C Rhyner, D Barber, O Palomares, R Pawankar, D Hamerlijnk, L Klimek, I Agache, E Angier, T Casale, M Fernandez-Rivas, S Halken, M Jutel, S Lau, G Pajno, G Sturm, E M Varga, R Gerth van Wijk, S Bonini, A Muraro, S Vieths
Adequate quality is essential for any medicinal product to be eligible for marketing. Quality includes verification of the identity, content and purity of a medicinal product in combination with a specified production process and its control. Allergen products derived from natural sources require particular considerations to ensure adequate quality. Here, we describe key aspects of the documentation on manufacturing and quality aspects for allergen immunotherapy products in the European Union and the United States...
November 17, 2017: Allergy
https://www.readbyqxmd.com/read/29150819/examining-reading-comprehension-text-and-question-answering-time-differences-in-university-students-with-and-without-a-history-of-reading-difficulties
#8
Megan Hebert, Xiaozhou Zhang, Rauno Parrila
The current study aimed to examine performance times during text reading and question answering of students with and without a history of reading difficulties. Forty-three university students with a history of reading difficulties (HRD) were compared to 124 university students without a history of reading difficulties on measures of word and nonword reading rate, text reading rate and comprehension, and question answering times. Results showed that students with HRD demonstrated slower word, nonword, and text reading rates than their peers, but had comparable reading comprehension scores...
November 17, 2017: Annals of Dyslexia
https://www.readbyqxmd.com/read/29150808/monitoring-enzymatic-degradation-of-emerging-contaminants-using-a-chip-based-robotic-nano-esi-ms-tool
#9
Lara F Stadlmair, Thomas Letzel, Johanna Graßmann
Up to now, knowledge of enzymes capable of degrading various contaminants of emerging concern (CEC) is limited, which is especially due to the lack of rapid screening methods. Thus, a miniaturized high-throughput setup using a chip-based robotic nanoelectrospray ionization system coupled to mass spectrometry has been developed to rapidly screen enzymatic reactions with environmentally relevant CECs. Three laccases, two tyrosinases, and two peroxidases were studied for their ability to transform ten pharmaceuticals and benzotriazole...
November 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29150796/gender-differences-in-chronic-liver-diseases-in-two-cohorts-of-2001-and-2014-in-italy
#10
Evangelista Sagnelli, Tommaso Stroffolini, Caterina Sagnelli, Mario Pirisi, Sergio Babudieri, Guido Colloredo, Maurizio Russello, Nicola Coppola, Giovanni Battista Gaeta, Bruno Cacopardo, Massimo De Luca, Piero Luigi Almasio
BACKGROUND: Gender differences in chronic liver disease (CLD) have been partially investigated. To extend the present knowledge, we evaluated 12,263 patients with CLD enrolled in two national surveys (9997 in 2001 and 2557 in 2014). METHODS: The two surveys prospectively recruited patients aged ≥ 18 referring to Italian liver units throughout the country using a similar clinical approach and analytical methods. RESULTS: The overall male to female ratio (M/F) was 1...
November 17, 2017: Infection
https://www.readbyqxmd.com/read/29150795/navigated-3d-ultrasound-versus-conventional-neuronavigation-during-awake-resections-of-eloquent-low-grade-gliomas-a-comparative-study-at-a-single-institution
#11
Andrej Šteňo, Vladimír Hollý, Peter Mendel, Veronika Šteňová, Ľubica Petričková, Gabriela Timárová, Michaela Jezberová, Víťazoslav Belan, Boris Rychlý, Jozef Šurkala, Juraj Šteňo
BACKGROUND: The data showing usefulness of navigated 3D-ultrasound (3DUS) during awake resections of eloquent gliomas are sparse. Results of surgeries performed using 3DUS were never compared to procedures guided by standard neuronavigation. The aim of this work is to assess the effectiveness of 3DUS during awake resections of eloquent low-grade gliomas (LGGs) by comparing surgical results of two series of patients operated on using conventional neuronavigation and using 3DUS. To our knowledge, a similar study is lacking in the literature...
November 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29150740/severe-rigid-scheuermann-kyphosis-in-adult-patients-correction-with-posterior-only-approach
#12
B Mirzashahi, M Chehrassan, A Arfa, M Farzan
PURPOSE: Scheuermann kyphosis is the most common structural kyphosis among adolescence and young people. Surgical treatment may be performed through combined anterior and posterior or posterior-only approaches; to our knowledge, the efficacy of posterior-only approach as less invasive procedure is not well studied in case of severe rigid Scheuermann kyphosis. MATERIALS AND METHODS: Eighteen patients with severe rigid Scheuermann kyphosis operated through only posterior approach from 2013 to 2016 were evaluated...
November 17, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29150706/application-of-directed-evolution-to-develop-ethanol-tolerant-oenococcus-oeni-for-more-efficient-malolactic-fermentation
#13
Alice L Betteridge, Krista M Sumby, Joanna F Sundstrom, Paul R Grbin, Vladimir Jiranek
Malolactic fermentation (MLF) is an important step in winemaking, which can be notoriously unreliable due to the fastidious nature of Oenococcus oeni. This study aimed to use directed evolution (DE) to produce a more robust strain of O. oeni having the ability to withstand high ethanol concentrations. DE involves an organism mutating and potentially adapting to a high stress environment over the course of extended cultivation. A continuous culture of O. oeni was established and exposed to progressively increasing ethanol content such that after approximately 330 generations, an isolate from this culture was able to complete MLF in high ethanol content medium earlier than its parent...
November 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29150697/a-novel-allele-of-tagw2-a1-is-located-in-a-finely-mapped-qtl-that-increases-grain-weight-but-decreases-grain-number-in-wheat-triticum-aestivum-l
#14
Huijie Zhai, Zhiyu Feng, Xiaofen Du, Yane Song, Xinye Liu, Zhongqi Qi, Long Song, Jiang Li, Linghong Li, Huiru Peng, Zhaorong Hu, Yingyin Yao, Mingming Xin, Shihe Xiao, Qixin Sun, Zhongfu Ni
A novel TaGW2-A1 allele was identified from a stable, robust QTL region, which is pleiotropic for thousand grain weight, grain number per spike, and grain morphometric parameters in wheat. Thousand grain weight (TGW) and grain number per spike (GNS) are two crucial determinants of wheat spike yield, and genetic dissection of their relationships can help to fine-tune these two components and maximize grain yield. By evaluating 191 recombinant inbred lines in 11 field trials, we identified five genomic regions on chromosomes 1B, 3A, 3B, 5B, or 7A that solely influenced either TGW or GNS, and a further region on chromosome 6A that concurrently affected TGW and GNS...
November 17, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29150655/reverse-engineering-protocols-for-controlling-spin-dynamics
#15
Qi Zhang, Xi Chen, D Guéry-Odelin
We put forward reverse engineering protocols to shape in time the components of the magnetic field to manipulate a single spin, two independent spins with different gyromagnetic factors, and two interacting spins in short amount of times. We also use these techniques to setup protocols robust against the exact knowledge of the gyromagnetic factors for the one spin problem, or to generate entangled states for two or more spins coupled by dipole-dipole interactions.
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150627/high-efficiency-backward-four-wave-mixing-by-quantum-interference
#16
Zi-Yu Liu, Jian-Ting Xiao, Jia-Kang Lin, Jun-Jie Wu, Jz-Yuan Juo, Chin-Yao Cheng, Yong-Fan Chen
Electromagnetically-induced-transparency-based four-wave mixing (FWM) in a resonant four-level double-Λ system has a maximum conversion efficiency (CE) of 25% due to spontaneous emission. Herein, we demonstrate that spontaneous emission can be considerably suppressed by arranging the applied laser beams in a backward configuration. With the backward double-Λ FWM scheme, we observe a CE of 63% in cold rubidium atoms with an optical depth (OD) of 48. To the best of our knowledge, this is the first observation of a CE exceeding the conversion limit in resonant FWM processes...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150589/change-in-hydration-indices-associated-with-an-increase-in-total-water-intake-of-more-than-0-5%C3%A2-l-day-sustained-over-4%C3%A2-weeks-in-healthy-young-men-with-initial-total-water-intake-below-2%C3%A2-l-day
#17
Jodi D Stookey, Janice Hamer, David W Killilea
This secondary data analysis addressed gaps in knowledge about effects of chronic water intake. Longitudinal data from the Adapt Study were used to describe effects of prescribing a sustained increase in water intake relative to baseline, for 4 weeks, on multiple indices of total body water (TBW) flux, regulation, distribution, and volume in five healthy, free-living, young men, with mean total water intake initially below 2 L/day. Indices were measured weekly. Within-person fixed effect models tested for significant changes in indices over time and associations between changes in indices...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29150574/-use-local-knowledge-and-trends-data-to-inform-future-plans-say-market-experts
#18
(no author information available yet)
No abstract text is available yet for this article.
November 18, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29150534/migration-and-cardiovascular-disease-risk-among-ghanaian-populations-in-europe-the-rodam-study-research-on-obesity-and-diabetes-among-african-migrants
#19
Daniel Boateng, Charles Agyemang, Erik Beune, Karlijn Meeks, Liam Smeeth, Matthias Schulze, Juliet Addo, Ama de-Graft Aikins, Cecilia Galbete, Silver Bahendeka, Ina Danquah, Peter Agyei-Baffour, Ellis Owusu-Dabo, Frank P Mockenhaupt, Joachim Spranger, Andre P Kengne, Diederick E Grobbee, Karien Stronks, Kerstin Klipstein-Grobusch
BACKGROUND: For migrant populations from sub-Saharan Africa, adverse cardiovascular disease (CVD) risk factors have been observed to be higher than found in their home country-based counterparts or among the host populations in high-income countries. Differences in absolute overall CVD risk, however, remain largely unexplained. We, therefore, predicted the differences in 10-year CVD risk among sub-Saharan African migrants (Ghanaians) living in 3 European cities and Ghana. METHODS AND RESULTS: For 3864 subjects aged 40 to 70 years from the multicenter RODAM study (Research on Obesity and Diabetes Among African Migrants) conducted among Ghanaian adults residing in rural and urban Ghana and 3 European cities (Amsterdam, Berlin, and London), 10-year risk of CVD was estimated using the Pooled Cohort Equations with estimates ≥7...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29150533/disparity-between-indications-for-and-utilization-of-implantable-cardioverter-defibrillators-in-asian-patients-with-heart-failure
#20
Yvonne May Fen Chia, Tiew-Hwa Katherine Teng, Eugene S J Tan, Wan Ting Tay, A Mark Richards, Calvin Woon Loong Chin, Wataru Shimizu, Sang Weon Park, Chung-Lieh Hung, Lieng H Ling, Tachapong Ngarmukos, Razali Omar, Bambang B Siswanto, Calambur Narasimhan, Eugene B Reyes, Cheuk-Man Yu, Inder Anand, Michael R MacDonald, Jonathan Yap, Shu Zhang, Eric A Finkelstein, Carolyn S P Lam
BACKGROUND: Implantable cardioverter defibrillators (ICDs) are lifesaving devices for patients with heart failure (HF) and reduced ejection fraction. However, utilization and determinants of ICD insertion in Asia are poorly defined. We determined the utilization, associations of ICD uptake, patient-perceived barriers to device therapy and, impact of ICDs on mortality in Asian patients with HF. METHODS AND RESULTS: Using the prospective ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) registry, 5276 patients with symptomatic HF and reduced ejection fraction (HFrEF) from 11 Asian regions and across 3 income regions (high: Hong Kong, Japan, Korea, Singapore, and Taiwan; middle: China, Malaysia, and Thailand; and low: India, Indonesia, and Philippines) were studied...
November 2017: Circulation. Cardiovascular Quality and Outcomes
keyword
keyword
29552
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"