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pediatric cognitive dysfunction

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https://www.readbyqxmd.com/read/29747930/baseline-and-outcome-assessment-in-pediatric-status-epilepticus
#1
REVIEW
Saba Jafarpour, Coral M Stredny, Juan Piantino, Kevin E Chapman
PURPOSE: To summarize different aspects of short and long-term outcomes associated with SE, including mortality, recurrence, subsequent epilepsy, neurocognitive dysfunction, imaging abnormalities, and health-related quality of life. METHODS: We searched MEDLINE for studies that assessed the short-term and long-term outcome of status epilepticus in pediatric population, including mortality, recurrence of seizure and status epilepticus, neurological, cognitive, or behavioral impairment, and health-related quality of life...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29705926/executive-functioning-heterogeneity-in-pediatric-adhd
#2
Michael J Kofler, Lauren N Irwin, Elia F Soto, Nicole B Groves, Sherelle L Harmon, Dustin E Sarver
Neurocognitive heterogeneity is increasingly recognized as a valid phenomenon in ADHD, with most estimates suggesting that executive dysfunction is present in only about 33%-50% of these children. However, recent critiques question the veracity of these estimates because our understanding of executive functioning in ADHD is based, in large part, on data from single tasks developed to detect gross neurological impairment rather than the specific executive processes hypothesized to underlie the ADHD phenotype...
April 28, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29671962/glycemic-control-is-related-to-cognitive-dysfunction-in-chinese-children-with-type-1-diabetes-mellitus
#3
Jing He, Shichen Li, Fang Liu, Hong Zheng, Xiang Yan, Yuting Xie, Xia Li, Zhiguang Zhou, Xiongzhao Zhu
BACKGROUND: Type 1 diabetes mellitus (T1DM) type 1 diabetes is considered to be a risk factor for developing cognitive difficulties. The present study examined if Chinese children with T1DM differ in cognitive performance from healthy control (HC) children, and whether cognitive dysfunction is related to glycemic control. METHODS: Using a cross-sectional design, we administered cognitive tests, including general intelligence tests, to pediatric T1DM patients (N = 105) and HC participants (N = 90)...
April 19, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29668025/general-movements-a-behavioral-biomarker-of-later-motor-and-cognitive-dysfunction-in-nicu-graduates
#4
Colleen Peyton, Christa Einspieler
Infants who have graduated from a neonatal intensive care unit require close follow-up because they have a greater chance of experiencing later motor and cognitive difficulties; however, these difficulties are often challenging to identify at an early age. The General Movement Assessment is a low-cost and highly reliable tool that can indicate abnormal neurological development in young high-risk infants, but it has not yet been widely implemented in the United States. In this review, we discuss the literature about the use of the General Movement Assessment in high-risk infants and how to implement the tool in a clinical setting...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29660023/radiation-induces-age-dependent-deficits-in-cortical-synaptic-plasticity
#5
Die Zhang, Wei Zhou, Thanh Thai Lam, Connie Weng, Lawrence Bronk, Duo Ma, Qiang Wang, Joseph G Duman, Patrick M Dougherty, David R Grosshans
Background: Radiation-induced cognitive dysfunction is a significant side effect of cranial irradiation for brain tumors. Clinically, pediatric patients are more vulnerable than adults. However, the underlying mechanisms of dysfunction, including reasons for age dependence, are still largely unknown. Previous studies have focused on the loss of hippocampal neuronal precursor cells and deficits in memory. However, survivors may also experience deficits in attention, executive function, or other non-hippocampal-dependent cognitive domains...
April 6, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29628064/long-term-effects-of-cognitive-behavioral-therapy-on-planning-and-prefrontal-cortex-function-in-pediatric-obsessive-compulsive-disorder
#6
Anouk van der Straten, Chaim Huyser, Lidewij Wolters, Damiaan Denys, Guido van Wingen
BACKGROUND: Previous studies showed changes after cognitive behavioral therapy (CBT) in prefrontal cortex function and cognitive performance in pediatric obsessive-compulsive disorder (OCD). It remains unknown whether these changes are short lasting or persistent during a period of brain maturation. Here, we investigated the long-term effects of CBT on planning performance and brain function in pediatric OCD using a longitudinal design. METHODS: Fifteen pediatric OCD patients and 16 matched healthy control subjects ranging from the ages of 8 to 18 years performed the Tower of London planning task during functional magnetic resonance imaging at three time points: before treatment, after 16 sessions of CBT, and after 2 years of naturalistic follow-up...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29570701/infant-outcome-at-four-years-of-age-after-intrapartum-sampling-of-scalp-blood-lactate-for-fetal-assessment-a-cohort-study
#7
Nana Wiberg, Tobias Wirenfeldt Klausen, Tobias Tyrberg, Lennart Nordström, Eva Wiberg-Itzel
OBJECTIVE: To correlate the value of lactate in fetal scalp blood at delivery and the outcomes of the offspring at four years of age. METHODS: Cases where scalp blood lactate was taken within sixty minutes before delivery were identified from the randomized trial "Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress". Data were grouped according to the generally accepted cutoffs for normality, pre-acidemia, acidemia and concentrations above mean +2 SD during the second stage...
2018: PloS One
https://www.readbyqxmd.com/read/29552934/postconcussive-symptoms-after-single-and-repeated-concussions-in-10-to-20-year-olds-a-cross-sectional-study
#8
Temitayo Oyefunmike Oyegbile, Bronson Elizabeth Delasobera, Nassim Zecavati
The objective was to characterize cognitive deficits and postconcussive symptoms in a pediatric population with no concussion, a single concussion, and ≥2 concussions, using a cross-sectional design. Cognitive function and postconcussive symptoms were assessed in participants (age 10-20) with no concussion (n = 1118), single concussion (n = 368), and repeated (≥2) concussions (n = 252). Analyses were adjusted for age and gender. Individuals with ≥2 concussions exhibited more total postconcussive symptoms; more loss of consciousness, amnesia and confusion; more headaches; and poorer cognitive function compared to no concussion and single concussion...
May 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29493552/pediatric-trauma-transfusion-and-cognitive-aids
#9
Anna Clebone
PURPOSE OF REVIEW: Trauma is the most common cause of pediatric mortality. Much of the research that led to life-saving interventions in adults, however, has not been replicated in the pediatric population. Children have important physiologic and anatomic differences from adults, which impact hemostasis and transfusion. Hemorrhage is a leading cause of death in trauma, and children have important differences in their coagulation profiles. Transfusion strategies, including the massive transfusion protocol and use of antifibrinolytics, are still controversial...
April 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29478607/the-spectrum-of-adult-onset-heritable-white-matter-disorders
#10
Guy Helman, Sunita Venkateswaran, Adeline Vanderver
Unique clinical presentations and magnetic resonance imaging patterns can help differentiate the various adult presentations of leukodystrophies and leukoencephalopathies. White-matter disorders are genetically based disorders affecting the central nervous system white matter, with or without peripheral nervous system involvement. These disorders predominantly affect patients in the pediatric population; however, a number of classic leukodystrophies can present in adulthood. Disease progression can be of variable onset with a broad range of symptoms, usually progressing from cognitive dysfunction...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29475430/systematic-review-of-pediatric-health-outcomes-associated-with-childhood-adversity
#11
Debora Lee Oh, Petra Jerman, Sara Silvério Marques, Kadiatou Koita, Sukhdip Kaur Purewal Boparai, Nadine Burke Harris, Monica Bucci
BACKGROUND: Early detection of and intervention in childhood adversity has powerful potential to improve the health and well-being of children. A systematic review was conducted to better understand the pediatric health outcomes associated with childhood adversity. METHODS: PubMed, PsycArticles, and CINAHL were searched for relevant articles. Longitudinal studies examining various adverse childhood experiences and biological health outcomes occurring prior to age 20 were selected...
February 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29462866/traumatic-brain-injury-sleep-disorders-and-psychiatric-disorders-an-underrecognized-relationship
#12
REVIEW
Anne M Morse, David R Garner
Traumatic brain injury (TBI) is commonplace among pediatric patients and has a complex, but intimate relationship with psychiatric disease and disordered sleep. Understanding the factors that influence the risk for the development of TBI in pediatrics is a critical component of beginning to address the consequences of TBI. Features that may increase risk for experiencing TBI sometimes overlap with factors that influence the development of post-concussive syndrome (PCS) and recovery course. Post-concussive syndrome includes physical, psychological, cognitive and sleep-wake dysfunction...
February 15, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29414546/unique-and-shared-areas-of-cognitive-function-in-children-with-intractable-frontal-or-temporal-lobe-epilepsy
#13
Nicole Law, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies. METHOD: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29403430/altered-regional-brain-cortical-thickness-in-pediatric-obstructive-sleep-apnea
#14
Paul M Macey, Leila Kheirandish-Gozal, Janani P Prasad, Richard A Ma, Rajesh Kumar, Mona F Philby, David Gozal
Rationale: Obstructive sleep apnea (OSA) affects 2-5% of all children and is associated with cognitive and behavioral deficits, resulting in poor school performance. These psychological deficits may arise from brain injury, as seen in preliminary findings of lower gray matter volume among pediatric OSA patients. However, the psychological deficits in OSA are closely related to functions in the cortex, and such brain areas have not been specifically assessed. The objective was to determine whether cortical thickness, a marker of possible brain injury, is altered in children with OSA...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29386446/-topics-on-child-development-in-pediatrics
#15
REVIEW
Kyoko Hirasawa
Over the past few decades, advances in neonatal medicine have increased survival rates among very-low-birth-weight (VLBW) babies. Despite improvements in short-term outcomes, there is increasing concern about the probability of mild cognitive dysfunction in this population. Our analysis of VLBW babies born in our hospital revealed that the incidence of mild developmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactive disorder (ADHD) at the age of 3 years is 7.2%, which is markedly higher than the 2...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/29385018/quantitative-volumetric-imaging-and-clinical-outcome-characterization-of-symptomatic-concussion-in-10-to-14-year-old-adolescent-athletes
#16
Christine L Mac Donald, Jason Barber, Jason Wright, David Coppel, Nina De Lacy, Steve Ottinger, Suzanne Peck, Chris Panks, Kody Zalewski, Samantha Sun, Nancy Temkin
OBJECTIVE: Prior work suggests that younger athletes may be more vulnerable to postconcussive syndrome. We investigated measures of clinical outcome and quantitative volumetric imaging in 10- to 14-year-old adolescent athletes to better understand the impact of concussion on this younger population. SETTING: Outpatient clinics. PARTICIPANTS: Ten- to 14-year-old symptomatic pediatric sports concussion patients and typically developing active controls...
January 30, 2018: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/29368955/translating-cognitive-vulnerability-theory-into-improved-adolescent-depression-screening-a-receiver-operating-characteristic-approach
#17
Joseph R Cohen, Felix K So, Benjamin L Hankin, Jami F Young
Traditionally, screening research tests how well a given symptom inventory can identify a concurrent depressive episode. Although developmental psychopathology could inform screening protocols for a myriad of depression outcomes (e.g., prospective depressive episodes), approaches typically used in research make it difficult to translate these findings. Using a translational analytic approach and multiwave longitudinal study design, we examined how screening for cognitive vulnerabilities (rumination, dysfunctional attitudes, and attributional style) may improve our ability to identify concurrent depressive episodes, prospective depressive episodes, first lifetime episodes of depression, and recurrent major depressive episodes...
January 25, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#18
Barrett D Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole N Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
April 2018: Radiation Research
https://www.readbyqxmd.com/read/29309954/impaired-theory-of-mind-in-chinese-children-and-adolescents-with-idiopathic-generalized-epilepsy-association-with-behavioral-manifestations-of-executive-dysfunction
#19
Ting Zhang, Lingyan Chen, Yu Wang, Mengmeng Zhang, Lanlan Wang, Xiangjun Xu, Gairong Xiao, Jing Chen, Yeru Shen, Nong Zhou
BACKGROUND: Epilepsy is a common neurological disorder with a core feature of cognitive impairments. Previous studies showed that patients with focal epilepsy have deficits in both theory of mind (ToM) and executive function (EF). However, there are few studies of ToM in patients with idiopathic generalized epilepsy (IGE), especially in populations with pediatric epilepsy. The aim of this study was to examine the characteristics of ToM and EF, including some of their subcomponents, and explore the relationship between them in Chinese children with IGE...
February 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29249552/pretreatment-cognition-in-patients-diagnosed-with-pediatric-brain-tumors
#20
Elin Irestorm, Sean Perrin, Ingrid Tonning Olsson
BACKGROUND: There is a large body of literature identifying risk factors for the long-term cognitive alterations found in survivors of pediatric brain tumors. Less is known about baseline cognitive functioning in this population, but studies suggest that cognitive dysfunctions are often present at the time of diagnosis. This study aimed to identify potential risk factors for lower cognitive function at the time of pediatric brain tumor diagnosis. METHODS: Participants were children and adolescents (n = 101) diagnosed with a pediatric brain tumor between 2006 and 2015, who underwent a pretreatment neuropsychologic assessment...
February 2018: Pediatric Neurology
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