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https://www.readbyqxmd.com/read/29338785/benefits-of-vce-003-2-a-cannabigerol-quinone-derivative-against-inflammation-driven-neuronal-deterioration-in-experimental-parkinson-s-disease-possible-involvement-of-different-binding-sites-at-the-ppar%C3%AE-receptor
#1
Concepción García, María Gómez-Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen Navarrete, M Luz Bellido, Moisés García-Arencibia, M Ruth Pazos, Eduardo Muñoz, Javier Fernández-Ruiz
BACKGROUND: Neuroprotection with cannabinoids in Parkinson's disease (PD) has been afforded predominantly with antioxidant or anti-inflammatory cannabinoids. In the present study, we investigated the anti-inflammatory and neuroprotective properties of VCE-003.2, a quinone derivative of the non-psychotrophic phytocannabinoid cannabigerol (CBG), which may derive its activity at the peroxisome proliferator-activated receptor-γ (PPARγ). The compound is also an antioxidant. METHODS: We evaluated VCE-003...
January 16, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29322073/high-fat-high-sucrose-diet-results-in-higher-bone-mass-in-aged-rats
#2
Akira Minematsu, Yasue Nishii, Susumu Sakata
Intake of high-fat/high-sucrose (HFS) diet or high fat diet influences bone metabolism in young rodents, but its effects on bone properties of aged rodents still remain unclear. This study aimed to examine the effects of HFS diet intake on trabecular bone architecture (TBA) and cortical bone geometry (CBG) in aged rats. Fifteen male Wistar rats over 1 year were randomly divided into two groups. One group was fed a standard laboratory diet (SLD) and the other group was fed a HFS diet for six months. The femur/tibia, obtained from both groups at the end of experimental period, were scanned by micro-computed tomography for TBA/CBG analyses...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29299794/characterization-of-the-serum-and-salivary-cortisol-response-to-the-intravenous-250%C3%A2-%C3%A2%C2%B5g-acth1-24-stimulation-test
#3
Brendan J Nolan, Jane Sorbello, Nigel Brown, Goce Dimeski, Warrick J Inder
PURPOSE: The ACTH1-24 stimulation test is commonly used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Given variations in CBG concentration and binding affinity, serum total cortisol may misclassify some patients. Salivary cortisol correlates well with serum free cortisol but is easier to measure and widely available in commercial laboratories. The aim of this study was to investigate the utility of measuring salivary cortisol during the ACTH1-24 stimulation test. DESIGN AND METHODS: Case-control study in a clinical research facility...
January 3, 2018: Endocrine
https://www.readbyqxmd.com/read/29273683/functional-implications-of-corticosteroid-binding-globulin-n-glycosylation
#4
Marc Simard, Caroline Underhill, Geoffrey L Hammond
Corticosteroid-binding globulin (CBG) is a plasma carrier of glucocorticoids. Human and rat CBGs have six N-glycosylation sites. Glycosylation of human CBG influences its steroid-binding activity and there are N-glycosylation sites in the reactive center loops (RCLs) of human and rat CBGs. Proteolysis of the RCL of human CBG causes a structural change that disrupts steroid binding. We now show that mutations of conserved N-glycosylation sites at N238 in human CBG and N230 in rat CBG disrupt steroid binding...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29262425/quantitative-determination-of-%C3%AE-9-thc-cbg-cbd-their-acid-precursors-and-five-other-neutral-cannabinoids-by-uhplc-uv-ms
#5
Yan-Hong Wang, Bharathi Avula, Mahmoud A ElSohly, Mohamed M Radwan, Mei Wang, Amira S Wanas, Zlatko Mehmedic, Ikhlas A Khan
Cannabinoids are a group of terpenophenolic compounds in the medicinal plant Cannabis sativa (Cannabaceae family). Cannabigerolic acid, Δ9-tetrahydrocannabinolic acid A, cannabidiolic acid, Δ9-tetrahydrocannabinol, cannabigerol, cannabidiol, cannabichromene, and tetrahydrocannabivarin are major metabolites in the classification of different strains of C. sativa. Degradation or artifact cannabinoids cannabinol, cannabicyclol, and Δ8-tetrahydrocannabinol are formed under the influence of heat and light during processing and storage of the plant sample...
December 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/29206229/pssalib-the-partial-propensity-stochastic-chemical-network-simulator
#6
Oleksandr Ostrenko, Pietro Incardona, Rajesh Ramaswamy, Lutz Brusch, Ivo F Sbalzarini
Chemical reaction networks are ubiquitous in biology, and their dynamics is fundamentally stochastic. Here, we present the software library pSSAlib, which provides a complete and concise implementation of the most efficient partial-propensity methods for simulating exact stochastic chemical kinetics. pSSAlib can import models encoded in Systems Biology Markup Language, supports time delays in chemical reactions, and stochastic spatiotemporal reaction-diffusion systems. It also provides tools for statistical analysis of simulation results and supports multiple output formats...
December 4, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29203333/perinatal-fluoxetine-increases-hippocampal-neurogenesis-and-reverses-the-lasting-effects-of-pre-gestational-stress-on-serum-corticosterone-but-not-on-maternal-behavior-in-the-rat-dam
#7
Mary Gemmel, Danny Harmeyer, Eszter Bögi, Marianne Fillet, Lesley A Hill, Geoffrey L Hammond, Thierry D Charlier, Jodi L Pawluski
There is increasing evidence that mental health concerns, stress-related mental illnesses, and parental stress prior to conception have long-term effects on offspring outcomes. However, more work is needed to understand how pre-gestational stress might affect neurobehavioral outcomes in the mother. We investigated how chronic stress prior to gestation affects the maternal behavior and related physiology, and aimed to determine the role that perinatal SSRIs may have in altering these stress effects. To do this, female Sprague-Dawley rats were subject to chronic unpredictable stress (CUS) prior to breeding and during the perinatal period they were administered fluoxetine (10mg/kg/day)...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29194043/the-role-of-corticosteroid-binding-globulin-in-the-evaluation-of-adrenal-insufficiency
#8
REVIEW
Kate C Verbeeten, Alexandra H Ahmet
Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation. In the assessment of adrenal insufficiency, many clinicians measure a total serum cortisol level, which assumes that CBG is present in normal concentrations and with a normal binding affinity for cortisol. CBG concentration and affinity are affected by a number of common factors including oral contraceptive pills (OCPs), fever and infection, as well as rare mutations in the serine protease inhibitor A6 (SERPINA6) gene, and as such, total cortisol levels might not be the ideal way to assess adrenal function in all clinical circumstances...
December 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29192420/use-of-a-levonorgestrel-releasing-intrauterine-device-for-menorrhagia-treatment-during-adjuvant-therapy-of-adrenocortical-carcinoma-with-mitotane
#9
Piotr Robert Szkodziak, Piotr Czuczwar, Sławomir Woźniak, Filip Szkodziak, Tomasz Paszkowski
Adrenocortical carcinoma is a rare tumour with high malignancy and poor prognosis. This tumour is rarely diagnosed in the reproductive age. Complete surgical resection is the only curative treatment for adrenal cancer in all stages. After surgery adjuvant chemotherapy is required. Mitotane is the most important drug in adrenal cancer chemotherapy. Mitotane's mode of action is not entirely explained. Animal studies have shown that the substance exerts a direct cytotoxic effect on the cells of the adrenal cortex...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29182999/analysis-of-cannabinoids-in-commercial-hemp-seed-oil-and-decarboxylation-kinetics-studies-of-cannabidiolic-acid-cbda
#10
Cinzia Citti, Barbara Pacchetti, Maria Angela Vandelli, Flavio Forni, Giuseppe Cannazza
Hemp seed oil from Cannabis sativa L. is a very rich natural source of important nutrients, not only polyunsaturated fatty acids and proteins, but also terpenes and cannabinoids, which contribute to the overall beneficial effects of the oil. Hence, it is important to have an analytical method for the determination of these components in commercial samples. At the same time, it is also important to assess the safety of the product in terms of amount of any psychoactive cannabinoid present therein. This work presents the development and validation of a highly sensitive, selective and rapid HPLC-UV method for the qualitative and quantitative determination of the main cannabinoids, namely cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG) and cannabidivarin (CBDV), present in 13 commercial hemp seed oils...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29155262/glucocorticoids-and-cbg-during-pregnancy-in-mammals-diversity-pattern-and-function
#11
REVIEW
Phoebe D Edwards, Rudy Boonstra
Pregnancy is one of the defining characteristics of placental mammals. Key in the growth and development of the fetus during pregnancy are the dynamics of glucocorticoids (GCs) and their binding protein - corticosteroid-binding globulin (CBG), which determines how much of the GCs are free and biologically active. Out of more than 5,000 species of placental mammals in 19 different orders, our understanding of the dynamics of maternal GCs and CBG during pregnancy is largely limited to the detailed study of 3 groups - sheep, laboratory rodents, and humans...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29151102/the-effect-of-genistein-supplementation-on-vitamin-d-levels-and-bone-turnover-markers-during-the-summer-in-healthy-postmenopausal-women-role-of-genotypes-of-isoflavone-metabolism
#12
María Pérez-Alonso, Laisa-Socorro Briongos, Marta Ruiz-Mambrilla, Eladio A Velasco, Lidia Linares, Luis Cuellar, José-Manuel Olmos, Daniel De Luis, Antonio Dueñas-Laita, José-Luis Pérez-Castrillón
AIMS: The objective of this study was to determine whether vitamin D and genistein supplementation had an additive beneficial effect on levels of vitamin D and bone markers and whether this effect was mediated by genes regulating isoflavone metabolism. MATERIALS AND METHODS: We carried out a prospective study in postmenopausal women randomized to calcium and vitamin D supplementation or calcium, vitamin D, and genistein supplementation. Vitamin D, parathyroid hormone (PTH), cross-linked C-telopeptide (CTX), and procollagen 1 N-terminal (P1NP) were determined by electrochemiluminescence...
November 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29144801/utility-of-a-single-late-night-plasma-cortisol-and-acth-for-the-diagnosis-of-cushing-s-syndrome
#13
Kush Dev Singh Jarial, Anil Bhansali, Kanchan K Mukherjee, Rimesh Pal, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva, Rama Walia
OBJECTIVE: To evaluate the diagnostic efficacy of various screening tests for the diagnosis of Cushing's syndrome (CS). METHODS: 35 patients of Cushing's syndrome and 16 patients of pseudo-Cushing's syndrome were enrolled. Assessment of 24h urinary free cortisol (UFC), late night salivary cortisol (LNSC), over night dexamethasone suppression test (ONDST), late night plasma cortisol (LNPC) and ACTH on outpatient basis, and during sleep as well as in awake state after 48 hours of hospital admission...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29067264/outpatient-management-of-steroid-induced-hyperglycaemia-and-steroid-induced-diabetes-in-people-with-lymphoproliferative-disorders-treated-with-intermittent-high-dose-steroids
#14
Jennifer Vidler, Charlotte Rogers, Deborah Yallop, Stephen Devereux, Ellinor Wellving, Orla Stewart, Alison Cox, Katharine F Hunt, Shireen Kassam
High dose steroids (HDS) are used in the treatment of haematological malignancies. The reported risk of steroid-induced diabetes (SID) is high. However, screening is not consistently performed. We implemented a protocol for detection and management of SID and steroid-induced hyperglycamia (SIH) in haematology outpatients receiving HDS. Eighty-three people were diagnosed with a lymphoproliferative disorder, of whom 6 had known Type 2 diabetes. Fifty-three people without known diabetes were screened by HbA1c and random venous plasma glucose...
September 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29066596/abundance-localization-and-functional-correlates-of-the-advanced-glycation-end-product-carboxymethyl-lysine-in-human-myocardium
#15
Martin M LeWinter, Douglas Taatjes, Takamaru Ashikaga, Bradley Palmer, Nicole Bishop, Peter VanBuren, Stephen Bell, Cameron Donaldson, Markus Meyer, Kenneth B Margulies, Margaret Redfield, David A Bull, Michael Zile
Advanced glycation end-products (AGEs) play a role in the pathophysiology of diabetes mellitus (DM) and possibly hypertension (HTN). In experimental DM, AGEs accumulate in myocardium. Little is known about AGEs in human myocardium. We quantified abundance, localization, and functional correlates of the AGE carboxymethyl lysine (CML) in left ventricular (LV) myocardium from patients undergoing coronary bypass grafting (CBG). Immunoelectron microscopy was used to quantify CML in epicardial biopsies from 98 patients (71 M, 27 F) with HTN, HTN + DM or neither (controls), all with normal LV ejection fraction...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29026609/ketosis-prone-diabetes-and-sle-co-presenting-in-an-african-lady-with-previous-gestational-diabetes
#16
S Hussain, S Keat, S V Gelding
We describe the case of an African woman who was diagnosed with ketosis-prone diabetes with diabetes-associated autoantibodies, after being admitted for diabetic ketoacidosis (DKA) precipitated by her first presentation of systemic lupus erythematosus (SLE). She had a seven-year history of recurrent gestational diabetes (GDM) not requiring insulin therapy, with return to normoglycaemia after each pregnancy. This might have suggested that she had now developed type 2 diabetes (T2D). However, the diagnosis of SLE prompted testing for an autoimmune aetiology for the diabetes, and she was found to have a very high titre of GAD antibodies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28975415/contour-changes-after-guided-bone-regeneration-of-large-non-contained-mandibular-buccal-bone-defects-using-deproteinized-bovine-bone-mineral-and-a-porcine-derived-collagen-membrane-an-experimental-in-vivo-investigation
#17
I Sanz-Martin, L Ferrantino, F Vignoletti, J Nuñez, N Baldini, M Duvina, J Alcaraz, M Sanz
OBJECTIVE: The objective of this study was to evaluate soft tissue contour changes after three different regenerative therapies in chronic ridge defects. MATERIAL AND METHODS: Buccal bone defects were created in the mandible of nine beagle dogs. Augmentation procedures were performed 3 months later using a bone replacement graft (BRG), resorbable collagen membrane (MBG), or a combination of both procedures (CBG). Silicone impressions were taken before tooth extraction (T1), before the augmentation procedure (T2), and 3 months after the regenerative surgeries (T3)...
October 3, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28970655/liraglutide-as-an-alternative-to-insulin-for-glycemic-control-in-intensive-care-unit-a-randomized-open-label-clinical-study
#18
Vishesh Verma, Narendra Kotwal, Vimal Upreti, Monish Nakra, Yashpal Singh, K Anand Shankar, Amit Nachankar, K V S Hari Kumar
BACKGROUND: Intravenous insulin is the cornerstone in the management of hyperglycemia in the Intensive Care Unit (ICU). We studied the efficacy of liraglutide compared with insulin in the ICU. MATERIALS AND METHODS: In this prospective, open-labeled, randomized study, we included 120 patients (15-65 years, either sex) admitted to ICU with capillary blood glucose (CBG) between 181 and 300 mg/dl. We excluded patients with secondary diabetes and APACHE score >24...
September 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28968639/ngs-pipe-a-flexible-easily-extendable-and-highly-configurable-framework-for-ngs-analysis
#19
Jochen Singer, Hans-Joachim Ruscheweyh, Ariane L Hofmann, Thomas Thurnherr, Franziska Singer, Nora C Toussaint, Charlotte K Y Ng, Salvatore Piscuoglio, Christian Beisel, Gerhard Christofori, Reinhard Dummer, Michael N Hall, Wilhelm Krek, Mitchell Levesque, Markus G Manz, Holger Moch, Andreas Papassotiropoulos, Daniel J Stekhoven, Peter Wild, Thomas Wüst, Bernd Rinn, Niko Beerenwinkel
Motivation: Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions, but the agreement of results from different facilities is often small. General standards for quality control, reproducibility, and documentation are missing. Results: We developed NGS-pipe, a flexible, transparent, and easy-to-use framework for the design of pipelines to analyze whole-exome, whole-genome, and transcriptome sequencing data...
August 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28919732/capillary-po2-does-not-adequately-reflect-arterial-po2-in-hypoxemic-copd-patients
#20
Friederike Sophie Magnet, Daniel Sebastian Majorski, Jens Callegari, Sarah Bettina Schwarz, Claudia Schmoor, Wolfram Windisch, Jan Hendrik Storre
PURPOSE: To compare arterial (PaO2) with capillary (PcO2) partial pressure of oxygen in hypoxemic COPD patients because capillary blood gas analysis (CBG) is increasingly being used as an alternative to arterial blood gas analysis (ABG) in a non-intensive care unit setting, although the agreement between PcO2 and PaO2 has not been evaluated in hypoxemic COPD patients. PATIENTS AND METHODS: Bland-Altman comparison of PaO2 and PcO2 served as the primary outcome parameter if PcO2 values were ≤60 mmHg and the secondary outcome parameter if PcO2 values were ≤55 mmHg...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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