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https://www.readbyqxmd.com/read/29768535/action-of-a-deproteinized-xenogenic-biomaterial-in-the-process-of-bone-repair-in-rats-submitted-to-inhalation-of-cigarette-smoke
#1
Daniela Vieira Buchaim, Patrícia Cincotto Dos Santos Bueno, Jesus Carlos Andreo, Domingos Donizeti Roque, José Sidney Roque, Marcelo Garcia Zilio, Jefferson Augusto Salatin, Natália Kawano, Gabriela Furlanette, Rogério Leone Buchaim
PURPOSE: To investigate if the inorganic bovine bone matrix changes the bone formation in rats submitted to inhalation of cigarette smoke. METHODS: Twenty Wistar rats were divided into two groups: Cigarette Clot Group (CCG), which in the inhalation chamber received the smoke of 10 cigarettes, 3 times a day, 10 minutes, for 30 days and had the surgical cavity filled by clot; Cigarette Biomaterial Group (CBG), submitted to the same inhalation technique but with the cavity filled by biomaterial...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29763585/seasonal-changes-in-acute-stressor-mediated-plasma-glucocorticoid-regulation-in-new-world-flying-squirrels
#2
Lanna M Desantis, Jeff Bowman, Mathilakath M Vijayan, Gary Burness
Southern flying squirrels have higher circulating cortisol levels than most vertebrates. However, regulation of tissue exposure to cortisol by the hormone's carrier protein, corticosteroid-binding globulin (CBG), appears to be altered due to lower-than-expected CBG expression levels, and a reduced affinity for cortisol. To assess the capacity of flying squirrels to regulate acute stress-mediated cortisol levels, we used the dexamethasone (DEX) suppression test followed by the adrenocorticotropic hormone (ACTH) stimulation test in both the breeding and non-breeding seasons, and quantified resultant changes in plasma cortisol and relative CBG levels...
May 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29755961/correlation-and-interchangeability-of-venous-and-capillary-blood-gases-in-non-critically-ill-neonates
#3
Ratna N G B Tan, Steffen C Pauws, Evelyne van Loon, Vivanne E H J Smits, Enrico Lopriore, Arjan B Te Pas
Background: Venous blood gas (VBG) is frequently used in the neonatal unit as alternative for capillary blood gas (CBG). However, studies reporting correlation are conflicting and data on interchangeability in neonates are lacking. Objective: We investigated the correlation and interchangeability of the components between VBG and CBG in infants admitted to the neonatal intensive care unit. Methods: In a prospective study in the neonatal unit in Leiden University Medical Center (Netherlands), simultaneously VBG and CBG were withdrawn in neonates when both venous puncture and intravenous access as blood gas monitoring was indicated...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29721586/corticosteroid-binding-globulin-induced-in-testicular-leydig-cells-by-perfluorooctanoic-acid-promotes-steroid-hormone-synthesis
#4
Sujie Sun, Jianshe Wang, Yin Lu, Jiayin Dai
Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Our previous proteomic profile analysis revealed that CBG levels increased in testes after PFOA treatment. In the present study, we verified its increase in mouse testes following oral exposure to PFOA (0, 1...
May 2, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29681284/alkylsilyl-speciation-and-direct-sample-preparation-of-plant-cannabinoids-prior-to-their-analysis-by-gc-ms
#5
Blanka Fodor, Imre Boldizsár, Ibolya Molnár-Perl
A literature criticism is given on methods currently using gas chromatography mass spectrometry (GC-MS) to determine plant cannabinoids (p-CBDs). In this study, trialkylsilylation of seven p-CBDs (including their transformation products formed in the drug user's body) was compared applying various alkylsilyl reagents1 and the mass fragmentation properties of the corresponding derivatives were characterized. Derivatization, mass fragmentation and quantitation related model investigations were optimized as a function of the reaction times and conditions...
August 27, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29679879/polygenic-risk-score-of-serpina6-serpina1-associates-with-diurnal-and-stress-induced-hpa-axis-activity-in-children
#6
Siddheshwar Utge, Katri Räikkönen, Eero Kajantie, Jari Lipsanen, Sture Andersson, Timo Strandberg, Rebecca M Reynolds, Johan G Eriksson, Jari Lahti
PURPOSE: Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood. Variation in genes SERPINA6 encoding for CBG, SERPINA2 and SERPINA1 (serpin family A member 6, 2, and 1) have been shown to influence morning plasma cortisol and CBG in adults. However, association of this genetic variation with diurnal and stress-induced salivary cortisol remain unknown. This study aims to investigate the effect of genetic variation in SERPINA6/2/1 loci on diurnal and stress-induced salivary cortisol in children...
April 13, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29678493/analysis-and-validation-of-a-new-extended-method-for-estimating-plasma-free-cortisol-including-neutrophil-elastase-and-competition-from-other-steroids
#7
Johanne Gudmand-Hoeyer, Johnny T Ottesen
A non-linear mechanistic model for the distribution of cortisol in plasma on free and bound forms is proposed. The influence of progesterone, testosterone and neutrophil elastase on the cortisol distribution in the blood is investigated. The activity of neutrophil elastase is directly included in the model with the concentration of elastase and the kinetic constants describing the activity of elastase collected in one single input variable. The model is very sensitive towards this input variable and fits data excellently, when it is allowed to be subject specific...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29673055/application-of-mesenchymal-stem-cells-to-enhance-non-union-bone-fracture-healing
#8
Mohammad Mousaei Ghasroldasht, Maryam M Matin, Hossein Kazemi Mehrjerdi, Hojjat Naderi-Meshkin, Ali Moradi, Masoud Rajabioun, Faeze Alipour, Samaneh Ghasemi, Mohammad Zare, Mahdi Mirahmadi, Hamid Reza Bidkhori, Ahmad Reza Bahrami
ECM components include a number of osteoinductive and osteoconductive factors, which are involved in bone fracture healing. In this study, a combination of adipose derived mesenchymal stem cells (Ad-MSCs), cancellous bone graft (CBG), and chitosan hydrogel (CHI) was applied to the in non-union bone fracture and healing effects were evaluated for the first time. After creation of animal models with non-union fracture in rats, they were randomly classified into seven groups. Radiography at 0, 2, 4 and 8 weeks after surgery, indicated the positive effects of Ad-MSCs+CBG+CHI and Ad-MSCs+CBG in treatment of bone fractures as early as 2 weeks after the surgery...
April 19, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29672873/space-time-analyses-of-alcohol-outlets-and-related-motor-vehicle-crashes-associations-at-city-and-census-block-group-levels
#9
Robert Lipton, William R Ponicki, Paul J Gruenewald, Andrew Gaidus
OBJECTIVES: Past research has linked alcohol outlet densities to drinking, drunken driving and alcohol-related motor vehicle crashes (MVCs). Because impaired drivers travel some distances from drinking places to crash locations, spatial relationships between outlets and crashes are complex. We investigate these relationships at three geographic levels: Census block groups (CBGs), adjacent (nearby) areas, and whole cities. METHODS: We examined risks for all injury MVCs as well as 'had been drinking' (HBD) and single-vehicle nighttime (SVN) subgroups using data from the Statewide Integrated Traffic Records System (SWITRS) across CBGs among 50 California cities from 2001 to 2008...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29663517/continuous-glucose-monitoring-results-in-lower-hba-1c-in-malaysian-women-with-insulin-treated-gestational-diabetes-a-randomized-controlled-trial
#10
S S Paramasivam, K Chinna, A K K Singh, J Ratnasingam, L Ibrahim, L L Lim, A T B Tan, S P Chan, P C Tan, S Z Omar, R W Bilous, S R Vethakkan
AIMS: To determine if therapeutic, retrospective continuous glucose monitoring (CGM) improves HbA1c with less hypoglycaemia in women with insulin-treated gestational diabetes mellitus (GDM). METHODS: This prospective, randomized controlled, open-label trial evaluated 50 women with insulin-treated GDM randomized to either retrospective CGM (6-day sensor) at 28, 32 and 36 weeks' gestation (Group 1, CGM, n = 25) or usual antenatal care without CGM (Group 2, control, n = 25)...
April 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29642898/enablers-and-barriers-for-women-with-gestational-diabetes-mellitus-to-achieve-optimal-glycaemic-control-a-qualitative-study-using-the-theoretical-domains-framework
#11
Ruth Martis, Julie Brown, Judith McAra-Couper, Caroline A Crowther
BACKGROUND: Glycaemic target recommendations vary widely between international professional organisations for women with gestational diabetes mellitus (GDM). Some studies have reported women's experiences of having GDM, but little is known how this relates to their glycaemic targets. The aim of this study was to identify enablers and barriers for women with GDM to achieve optimal glycaemic control. METHODS: Women with GDM were recruited from two large, geographically different, hospitals in New Zealand to participate in a semi-structured interview to explore their views and experiences focusing on enablers and barriers to achieving optimal glycaemic control...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29599801/continuous-flash-glucose-monitoring-in-children-with-congenital-hyperinsulinism-first-report-on-accuracy-and-patient-experience
#12
Hussain Alsaffar, Lucy Turner, Zoe Yung, Mohammed Didi, Senthil Senniappan
Background: The factory calibrated FreeStyle Libre (FSL) flash glucose monitoring system has been recently introduced for use in patients with diabetes mellitus. There are no reports available regarding its use in patients with congenital hyperinsulinism (CHI). We have assessed the accuracy of FSL compared to the finger prick capillary blood glucose (CBG) over 2 weeks period in patients with CHI and evaluated the parents' experience of using FSL. Methods: Four hundred sixty-seven episodes of CBG along with corresponding swipe FSL readings were available from 11 children with CHI (0...
2018: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/29578063/diversity-of-virulence-genes-in-brucella-melitensis-and-brucella-abortus-detected-from-patients-with-rheumatoid-arthritis
#13
Hossin Ali Rahdar, Reza Golmohammadi, Reza Mirnejad, Ramezan Ali Ataee, Gholam Hossein Alishiri, Hossein Kazemian
The presence of Brucella melitensis and Brucella abortus genomes were investigated in the synovial fluid (SF) samples from 90 patients with rheumatoid arthritis (RA). DNA extraction and PCR assay were performed for simultaneous identification and discrimination of B. melitensis and B. abortus from the SF using three specific primers. After gel electrophoresis, the PCR products were confirmed by DNA sequencing. The cbg, omp31, manA, virB, and znuA virulence genes typing were performed by multiplex-PCR. Of the 90 samples, 14 were positive for B...
March 22, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29576358/a-lecithin-phosphatidylserine-and-phosphatidic-acid-complex-pas-reduces-symptoms-of-the-premenstrual-syndrome-pms-results-of-a-randomized-placebo-controlled-double-blind-clinical-trial
#14
Katja Schmidt, Nicole Weber, Meir Steiner, Nadin Meyer, Anne Dubberke, David Rutenberg, Juliane Hellhammer
BACKGROUND & AIMS: Many women experience emotional and physical symptoms around the time of ovulation and more so before menstruation interfering with their daily normal life also known as premenstrual syndrome (PMS). Recent observational data suggest that supplementation with Lipogen's phosphatidylserine (PS) and phosphatidic acid (PA) complex (PAS) alleviates these PMS symptoms. The aim of this study was to confirm these observations on the effects of PAS on PMS symptom severity within a controlled clinical trial setting...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29547932/network-based-integration-of-multi-omics-data-for-prioritizing-cancer-genes
#15
Christos Dimitrakopoulos, Sravanth Kumar Hindupur, Luca Häfliger, Jonas Behr, Hesam Montazeri, Michael N Hall, Niko Beerenwinkel
Motivation: Several molecular events are known to be cancer-related, including genomic aberrations, hypermethylation of gene promoter regions, and differential expression of microRNAs. These aberration events are very heterogeneous across tumors and it is poorly understood how they affect the molecular makeup of the cell, including the transcriptome and proteome. Protein interaction networks can help decode the functional relationship between aberration events and changes in gene and protein expression...
March 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29547045/serum-free-cortisol-during-glucagon-stimulation-test-in-healthy-short-statured-children-and-adolescents
#16
Naomi Weintrob, Anita Schachter Davidov, Anat Segev Becker, Galit Israeli, Asaf Oren, Ori Eyal
OBJECTIVE: The total cortisol (TC) response may be measured during the glucagon stimulation test (GST) for growth hormone (GH) reserve in order to assess the integrity of the hypothalamic-pituitary-adrenal (HPA) axis. Measurements of TC are unreliable in conditions of albumin and cortisol-binding globulin (CBG) alterations (e.g., hypoproteinemia or CBG deficiency). We aimed to measure the serum free cortisol (sFC) response to the GST in children and adolescents and determine whether it could predict the GH response to glucagon stimulation...
March 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29546743/secondary-adrenal-insufficiency-in-pregnancy-any-differences
#17
Stephan Petersenn
Secondary adrenal insufficiency may pose specific challenges during pregnancy. The interpretation of diagnostic tests is hindered by physiological adaptations of the HPA axis. Due the relevant increases in CBG, measurement of salivary cortisol may be preferable, but lacks sufficiently established cut-offs both for early-morning evaluation and during dynamic testing. Hydrocortisone should be used for replacement to avoid overexposure of the fetus, with dose adjustments according to clinical judgement. To account for increased free cortisol levels during the course of pregnancy, hydrocortisone may be increased by 5-7...
March 15, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29539260/design-of-polyphosphate-inhibitors-a-molecular-dynamics-investigation-on-polyethylene-glycol-linked-cationic-binding-groups
#18
Amirhossein Mafi, Srinivas Abbina, Manu Thomas Kalathottukaren, James H Morrissey, Charles Haynes, Jayachandran N Kizhakkedathu, Jim Pfaendtner, Keng C Chou
Inorganic polyphosphate (polyP) released by human platelets has recently been shown to activate blood clotting and identified as a potential target for the development of novel antithrombotics. Recent studies have shown that polymers with cationic binding groups (CBGs) inhibit polyP and attenuate thrombosis. However, a good molecular-level understanding of the binding mechanism is lacking for further drug development. While molecular dynamics (MD) simulation can provide molecule-level information, the time scale required to simulate these large biomacromolecules makes classical MD simulation impractical...
April 9, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29506005/simultaneous-determination-of-columbianetin-%C3%AE-d-glucopyranoside-and-columbianetin-in-a-biological-sample-by-high-performance-liquid-chromatography-with-fluorescence-detection-and-identification-of-other-columbianetin-%C3%AE-d-glucopyranoside-metabolites-by-ultra
#19
Lu Zhang, Yuanyuan Ge, Jin Li, Jia Hao, Hui Wang, Jun He, Xiu-Mei Gao, Yan-Xu Chang
Columbianetin-β-d-glucopyranoside (CBG) and its metabolite columbianetin (CBN) are the bioactive constituents of Angelicae pubescentis radix (APR). They exhibit the anti-platelet aggregation, anti-inflammatory and analgesic properties. The absorption, distribution, metabolism and excretion (ADME) of CBG has not been reported to date. Both high-performance liquid chromatography with fluorescence detection and ultra high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry methods were developed and validated for the study of ADME of CBG...
May 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29488442/factors-associated-with-timely-blood-glucose-testing-and-insulin-administration-in-patients-receiving-mealtime-insulin-coverage-in-medical-surgical-units
#20
Ann R Kaisen, Janet A Parkosewich, Kelly A Bonito
Purpose The purpose of the study was to identify the rate and factors associated with timely mealtime capillary blood glucose (CBG) testing and insulin coverage in hospitalized patients with diabetes. Methods A descriptive-correlational design was used with a random sample of patients (n = 77) and nurses (n = 36) on a medicine and a neuroscience unit of a large Magnet hospital. After written consent was obtained, post-meal patient and nurse interviews were conducted to collect information about patient, nurse, and situational factors known to influence timely mealtime diabetes care...
April 2018: Diabetes Educator
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