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https://www.readbyqxmd.com/read/29235879/experimental-studies-on-artifacts-and-tumor-enhancement-on-gadoxetic-acid-enhanced-arterial-phase-liver-mri-in-a-rabbit-vx2-tumor-model
#1
Takahiro Tsuboyama, Gregor Jost, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Hubertus Pietsch, Noriyuki Tomiyama
Background Rapid injection of gadoxetic acid is reported to produce more frequent artifacts and lower vascular enhancement on arterial phase liver magnetic resonance imaging (MRI). However, its effect on tumor enhancement and the mechanism of the artifacts remain unclear. Purpose To evaluate the effect of rapid injection of gadoxetic acid on artifacts and tumor enhancement during arterial phase liver MRI, and on arterial blood gases (ABGs) which may explain the cause of the artifacts. Material and Methods ABG analysis was performed in 13 free-breathing rabbits after rapid injection (1 mL/s; injection time = 0...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29224257/models-of-care-for-non-invasive-ventilation-in-the-acute-copd-comparison-of-three-tertiary-hospitals-act3-study
#2
Kerry Parker, Vara Perikala, Ali Aminazad, Zheng Deng, Brigitte Borg, Catherine Buchan, Jo Toghill, Louis B Irving, Jeremy Goldin, David Charlesworth, Ajay Mahal, Suhith Illesinghe, Matthew T Naughton, Alan Young
BACKGROUND AND OBJECTIVE: Non-invasive ventilation (NIV) improves clinical outcomes in hypercapnic acute exacerbations of COPD (AECOPD), but the optimal model of care remains unknown. METHODS: We conducted a prospective observational non-inferiority study comparing three models of NIV care: general ward (Ward) (1:4 nurse to patient ratio, thrice weekly consultant ward round), a high dependency unit (HDU) (1:2 ratio, twice daily ward round) and an intensive care unit (ICU) (1:1 ratio, twice daily ward round) model in three similar teaching tertiary hospitals...
December 10, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29210949/clinical-characteristics-and-treatment-outcomes-for-patients-with-external-auditory-canal-cholesteatoma
#3
Shinya Morita, Yuji Nakamaru, Atsushi Fukuda, Keishi Fujiwara, Kimiko Hoshino, Akihiro Homma
OBJECTIVE: We aimed to evaluate the clinical features and treatment outcomes for patients with idiopathic and secondary external auditory canal cholesteatoma (EACC), and to validate the treatment strategy from the perspective of hearing as well as etiology and staging. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center and affiliated hospitals. PATIENTS: Fifty-eight patients with idiopathic EACC and 14 patients with secondary EACC...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29210947/toward-optimizing-cervical-vestibular-evoked-myogenic-potentials-cvemp-combining-air-bone-gap-and-cvemp-thresholds-to-improve-diagnosis-of-superior-canal-dehiscence
#4
Kimberley S Noij, Maria J Duarte, Kevin Wong, Y Song Cheng, Salwa Masud, Barbara S Herrmann, Hugh D Curtin, Vivek V Kanumuri, John J Guinan, Elliott D Kozin, Osama Tarabichi, David H Jung, Daniel J Lee, Steven D Rauch
OBJECTIVE: To develop a novel approach combining low-frequency air-bone gap (ABG) and cervical vestibular evoked myogenic potential (cVEMP) thresholds to improve screening for superior canal dehiscence (SCD) syndrome. STUDY DESIGN: Retrospective study. SETTING: Tertiary care center. PATIENTS: One hundred forty patients with SCD and 21 healthy age-matched controls were included. Ears for each patient were divided into three groups based on computed tomography (CT) findings: 1) dehiscent, 2) thin, or 3) unaffected...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29186488/a-putative-r3-myb-repressor-is-the-candidate-gene-underlying-atroviolacium-a-locus-for-anthocyanin-pigmentation-in-tomato-fruit
#5
Xue Cao, Zhengkun Qiu, Xiaotian Wang, Tong Van Giang, Xiaolin Liu, Jing Wang, Xiaoxuan Wang, Jianchang Gao, Yanmei Guo, Yongchen Du, Guoping Wang, Zejun Huang
Anthocyanins are potential health-promoting compounds in the human diet. The atv (atroviolacium) locus, derived from the wild tomato species Solanum cheesmaniae, has been shown to enhance anthocyanin pigmentation in tomato fruit when it co-exists with either the Aft (Anthocyanin fruit) or the Abg (Aubergine) locus. In the present study, the atv locus was fine-mapped to an approximately 5.0-kb interval on chromosome 7. A putative R3 MYB repressor was identified in this interval and is hereby designated as SlMYBATV...
November 25, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29180962/tetradecyl-2-3-dihydroxybenzoate-improves-the-symptoms-of-diabetic-mice-by-modulation-of-insulin-and-adiponectin-signaling-pathways
#6
Lan Xiang, Jing Li, Yanhui Wang, Ruiqi Tang, Qian Wang, Qiaobei Wu, Jianhua Qi
Background: Tetradecyl 2,3-dihydroxybenzoate (ABG-001) derived from Chinese medicine, gentiana regescens Franch is a leading compound with NGF mimic effect, it can induce neurite outgrowth of PC12 cells via the IGF-1/PI3K/ERK signaling pathway. Thus, we inferred that this compound had anti-diabetic effect and used streptozocin (STZ)-induced diabetic mice to indicate it. Methods: ABG-001 was synthesized with 2,3-dihydroxybenzoic acid and tetradecyl alcohol under certain reaction conditions. STZ-induced diabetic mice were used to investigate anti-diabetic effect...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29173817/adaptive-bone-remodeling-with-new-design-of-the-abg-stem-densitometric-study
#7
Jorge López-Subías, Juan J Panisello, Jesús M Mateo-Agudo, Marina Lillo-Adán, Antonio Herrera
To establish the pattern of bone remodeling caused by a cementless, anatomic implant, we intend to evaluate the changes in bone mineral density observed after surgery in the Gruen zones. A controlled, prospective study was carried out, in which a group of 37 patients with primary coxarthrosis were densitrometrically analyzed over the 1 year period following the implant of an ANATO stem (Stryker). The patient's healthy hip was taken as the control. Any differences in the remodeling pattern were compared according to age, body mass index, and implant size...
September 28, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29172396/the-effect-of-endoscopic-tympanoplasty-on-cochlear-function
#8
Isa Kaya, Goksel Turhal, Arin Ozturk, Sercan Gode, Cem Bilgen, Tayfun Kirazli
Objectives: The aim of this prospective clinical study was to measure the audiologic outcomes of the patients that underwent endoscopic transcanal cartilage tympanoplasty, and to investigate the effects on cochlear function. Methods: Thirty-three patients (33 ears) who were diagnosed with noncomplicated chronic otitis media and underwent endoscopic transcanal cartilage tympanoplasty technique were included. Pre- and postoperative first month distortion product otoacoustic emission (DPOAE) signal-to-noise ratio (SNR), bone conduction hearing levels and air bone gap (ABG) values were measured and total endoscope usage time was noted...
November 28, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29171673/does-the-diameter-of-the-stapes-prosthesis-really-matter-a-prospective-clinical-study
#9
Daniele Bernardeschi, Daniele De Seta, Giuseppina Canu, Francesca Yoshie Russo, Evelyne Ferrary, Ghizlene Lahlou, Olivier Sterkers
OBJECTIVES/HYPOTHESIS: To evaluate the influence of the diameter of stapes prosthesis on functional outcomes in stapes surgery. STUDY DESIGN: Prospective cohort study. METHODS: Fifty consecutive small fenestra stapedotomies performed using a 0.4-mm-diameter prosthesis were compared with 50 consecutive small fenestra stapedotomies carried out using a 0.6-mm-diameter piston. Audiological assessment following the recommendations of the Committee on Hearing and Equilibrium was performed 1 month after surgery...
November 24, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29157625/pediatric-type-1-cartilage-tympanoplasty-outcomes-a-comparison-of-short-and-long-term-hearing-results
#10
Isa Kaya, Murat Benzer, Sercan Gode, Furkan Sahin, Cem Bilgen, Tayfun Kirazli
OBJECTIVE: Tympanoplasty is a commonly used procedure in children as in adults. The purposes of this study were to evaluate and report the long term results of type 1 cartilage tympanoplasty in pediatric population. Short term and long term hearing outcomes were compared according to age and perforation location. METHODS: We retrospectively evaluated a total of 76 of 93 patients who had regularly come to visits (38 male and 38 female) with chronic otitis media (COM) and who were younger than 16 years (range, 9-16 years) and underwent a primary type 1 tympanoplasty in tertiary medical center...
November 17, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29152544/determinants-and-outcome-of-metabolic-acidosis-in-diarrheal-children-under-5-years-of-age-in-an-urban-critical-care-ward-in-bangladesh
#11
Sharifuzzaman, Monira Sarmin, Tahmeed Ahmed, Tahmina Alam, Shoeb Bin Islam, Md Munirul Islam, Mohammod Jobayer Chisti
We evaluated the independent determinants and outcome of metabolic acidosis in diarrheal children. Children under 5 years of age admitted with diarrhea and severe respiratory distress in the critical care ward at Dhaka Hospital of icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh) from April 2010 to April 2014 who had their reports of arterial blood gas analyses were enrolled in the study. We compared clinical and laboratory characteristics between the study children with (cases = 74) and without metabolic acidosis (controls = 65)...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29143462/evaluation-of-immediate-implants-augmented-with-autogenous-bone-melatonin-composite-graft-in-the-esthetic-zone-a-randomized-controlled-trial
#12
Hala H A Hazzaa, Naglaa Sh El-Kilani, Shadia Abd-Elhameed Elsayed, Phoebe M Abd El Massieh
PURPOSE: To evaluate the clinical and radiographic outcomes following the application of autogenous bone (ABG)/melatonin composite graft around immediate implants in the esthetic zone compared to ABG alone. MATERIALS AND METHODS: Twenty-six patients with two nonrestorable anterior/premolar teeth were randomly classified into two equal groups. Dental implants were immediately inserted either with ABG (control group) or ABG/melatonin (test group). Outcome measures were peri-implant sulcus depth (PD), gingival index (GI), and wound healing scores...
November 16, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29143201/newborn-screening-for-lysosomal-storage-disorders-by-tandem-mass-spectrometry-in-north-east-italy
#13
Alberto B Burlina, Giulia Polo, Leonardo Salviati, Giovanni Duro, Carmela Zizzo, Andrea Dardis, Bruno Bembi, Chiara Cazzorla, Laura Rubert, Roberta Zordan, Robert J Desnick, Alessandro P Burlina
BACKGROUND: Lysosomal storage diseases (LSDs) are inborn errors of metabolism resulting from 50 different inherited disorders. The increasing availability of treatments and the importance of early intervention have stimulated newborn screening (NBS) to diagnose LSDs and permit early intervention to prevent irreversible impairment or severe disability. We present our experience screening newborns in North East Italy to identify neonates with Mucopolysaccharidosis type I (MPS I) and Pompe, Fabry, and Gaucher diseases...
November 15, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#14
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29121374/boomerang-shaped-vs-shield-shaped-chondroperichondrial-cartilage-grafts-for-type-1-tympanoplasty-in-children-a-study-of-121-patients
#15
Can Özbay, Fatih Kemal Soy, Erkan Kulduk, Riza Dundar, Ahmet Yükkaldiran, Osman Kadir Güler, Ertan Koç
Many techniques and graft materials have been used for the reconstruction of the tympanic membrane. We conducted a retrospective study to compare anatomic and functional outcomes of type 1 tympanoplasty that we performed with boomerang-shaped chondroperichondrial cartilage grafts (BSGs) and shield-shaped chondroperichondrial cartilage grafts (SSGs) in pediatric patients. Our study population was made up 121 patients-61 boys and 60 girls, aged 7 to 16 years (mean: 12.4)-who had undergone a type 1 tympanoplasty...
October 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29073815/effect-of-esterified-hyaluronic-acid-as-middle-ear-packing-in-tympanoplasty-for-adhesive-otitis-media
#16
Rui Deng, Yanqing Fang, Jun Shen, Xiong Ou, Wenyi Liuyan, Bin Wan, Yasheng Yuan, Xiaoting Cheng, Yilai Shu, Bing Chen
OBJECTIVES: The goal of this study was to evaluate the effects of middle ear packing agents (MEPA) on post-operative hearing improvement and complications after tympanoplasty in patients with adhesive otitis media (OM). MATERIALS AND METHODS: Patients with adhesive OM who underwent tympanoplasty surgery were enrolled in the study between January 2012 and January 2015. A total of 205 patients who received canal wall-down tympanoplasty with ossicular chain reconstruction were randomized into one of the three groups with different MEPA...
October 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29018495/frequency-dependence-hearing-loss-evaluation-in-perforated-tympanic-membrane
#17
Mohammed Radef Dawood
Introduction  Tympanic membrane perforation is a relatively common problem that predisposes patients to varying degrees of conductive hearing loss. Objective  The objective of this study is to evaluate and analyze the frequency dependence hearing loss in tympanic membrane perforation based on the size and the site of perforation. Methods  For the study, I selected 71 patients' (89) ears for the cross-sectional study with tympanic membrane perforations; I examined the size and the site of perforations under the microscope and classified them into small, moderate, large, and subtotal perforations, and into anterior central, posterior central, malleolor central, and big central perforations...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28974329/long-term-outcomes-in-older-patients-with-hyperglycemia-on-admission-for-ischemic-stroke
#18
Alexander Gorshtein, Ilan Shimon, Tzipora Shochat, Oren Amitai, Amit Akirov
AIMS: Evaluate the association between admission blood glucose (ABG) and mortality in older patients with or without diabetes mellitus (DM) hospitalized for acute ischemic stroke (AIS). METHODS: Observational data of patients ≥65years, admitted for AIS between January 2011 and December 2013. ABG levels were classified to categories: ≤70 (low), 70-110 (normal), 111-140 (mildly elevated), 141-180mg/dl (moderately elevated) and >180mg/dl (markedly elevated)...
September 30, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28956143/bioactive-glass-obliteration-of-the-mastoid-significantly-improves-surgical-outcome-in-non-cholesteatomatous-chronic-otitis-media-patients
#19
Joris Vos, Pieter de Vey Mestdagh, David Colnot, Pepijn Borggreven, Claudia Orelio, Jasper Quak
This retrospective follow-up study evaluates the efficacy and safety of bioactive glass (BAG) S53P4 when applied as filler material in mastoid obliteration surgery performed on non-cholesteatomatous chronic otitis media (NC-COM) patients with chronically discharging ears despite conservative therapy. 94 Patients (96 ears) were included. Patients underwent either intact canal wall (ICW) or canal wall down (CWD) mastoid surgery between 2005 and 2015. The intervention group comprised 23 patients (23 ears) who were treated with additional mastoid obliteration using BAG S53P4; the remaining 71 patients (73 ears) were considered controls...
December 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28951466/emergency-department-blood-gas-utilization-and-changes-in-ventilator-settings
#20
Haitham S Al Ashry, Jeremy B Richards, Daniel F Fisher, Jeffrey Sankoff, Todd A Seigel, Lauren B Angotti, Susan R Wilcox
BACKGROUND: Mechanically ventilated patients increasingly spend hours in emergency department beds before ICU admission. This study evaluated the performance of blood gases in mechanically ventilated subjects in the emergency department and subsequent changes to mechanical ventilation settings. METHODS: This was a multi-center, prospective, observational study of subjects ventilated in the emergency department, conducted at 3 academic emergency departments from July 2011 to March 2013...
September 26, 2017: Respiratory Care
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