Nicole C Goodwin, Zhi-Ming Ding, Bryce A Harrison, Eric D Strobel, Angela L Harris, Melinda Smith, Andrea Y Thompson, Wendy Xiong, Faika Mseeh, Debra J Bruce, Damaris Diaz, Suma Gopinathan, Ling Li, Emily O'Neill, Mary Thiel, Alan G E Wilson, Kenneth G Carson, David R Powell, David B Rawlins
The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control blood glucose levels in diabetic patients. Herein we report the discovery of LX2761, a locally-acting SGLT1 inhibitor that is highly potent in vitro and delays intestinal glucose absorption in vivo to improve glycemic control.
January 3, 2017: Journal of Medicinal Chemistry