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Pathology education

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https://www.readbyqxmd.com/read/28097472/proceedings-of-the-third-international-molecular-pathological-epidemiology-mpe-meeting
#1
REVIEW
Peter T Campbell, Timothy R Rebbeck, Reiko Nishihara, Andrew H Beck, Colin B Begg, Alexei A Bogdanov, Yin Cao, Helen G Coleman, Gordon J Freeman, Yujing J Heng, Curtis Huttenhower, Rafael A Irizarry, N Sertac Kip, Franziska Michor, Daniel Nevo, Ulrike Peters, Amanda I Phipps, Elizabeth M Poole, Zhi Rong Qian, John Quackenbush, Harlan Robins, Peter K Rogan, Martha L Slattery, Stephanie A Smith-Warner, Mingyang Song, Tyler J VanderWeele, Daniel Xia, Emily C Zabor, Xuehong Zhang, Molin Wang, Shuji Ogino
Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases...
January 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28091357/assessment-of-the-need-for-a-cardiac-morphology-curriculum-for-paediatric-cardiology-fellows
#2
Lindsay S Rogers, Melissa Klein, Jeanne James, Michael FitzGerald
BACKGROUND: Expert knowledge of cardiac malformations is essential for paediatric cardiologists. Current cardiac morphology fellowship teaching format, content, and nomenclature are left up to the discretion of the individual fellowship programmes. We aimed to assess practices and barriers in morphology education, perceived effectiveness of current curricula, and preferences for a standardised fellow morphology curriculum. METHODS: A web-based survey was developed de novo and administered anonymously via e-mail to all paediatric cardiology fellowship programme directors and associate directors in the United States of America; leaders were asked to forward the survey to fellows...
January 16, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28089173/use-of-interactive-ibooks-for-patient-education-in-otology
#3
Omid Moshtaghi, Yarah M Haidar, Ronald Sahyouni, Ramin Rajaii, Afsheen Moshtaghi, Amin Mahmoodi, Yaser Ghavami, Harrison W Lin, Hamid R Djalilian
INTRODUCTION: Physicians in the ambulatory setting face challenges in adequately educating patients in a brief office encounter. OBJECTIVE: To evaluate the efficacy of an iPad-based interactive educational module (iBook) in various otologic pathologies. METHODS: Patients presenting with symptoms of tinnitus, dizziness, hearing loss, or cochlear implant evaluation were included. In total, 44 patients received the iBook and 22 patients served as controls...
December 29, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28088837/disease-severity-classification-using-quantitative-magnetic-resonance-imaging-data-of-cartilage-in-femoroacetabular-impingement
#4
Lisa L Henn, John Hughes, Eleena Iisakka, Jutta Ellermann, Shabnam Mortazavi, Connor Ziegler, Mikko J Nissi, Patrick Morgan
Femoroacetabular impingement (FAI) is a condition in which subtle deformities of the femoral head and acetabulum (hip socket) result in pathological abutment during hip motion. FAI is a common cause of hip pain and can lead to acetabular cartilage damage and osteoarthritis. For some patients with FAI, surgical intervention is indicated, and it can improve quality of life and potentially delay the onset of osteoarthritis. For other patients, however, surgery is contraindicated because significant cartilage damage has already occurred...
January 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28087402/accuracy-is-in-the-eyes-of-the-pathologist-the-visual-interpretive-process-and-diagnostic-accuracy-with-digital-whole-slide-images
#5
Tad T Brunyé, Ezgi Mercan, Donald L Weaver, Joann G Elmore
Digital whole slide imaging is an increasingly common medium in pathology, with application to education, telemedicine, and rendering second opinions. It has also made it possible to use eye tracking devices to explore the dynamic visual inspection and interpretation of histopathological features of tissue while pathologists review cases. Using whole slide images, the present study examined how a pathologist's diagnosis is influenced by fixed case-level factors, their prior clinical experience, and their patterns of visual inspection...
January 10, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28077535/the-impact-of-a-perceptual-and-adaptive-learning-module-on-transoesophageal-echocardiography-interpretation-by-anaesthesiology-residents
#6
B T Romito, S Krasne, P J Kellman, A Dhillon
BACKGROUND: The role of transoesophageal echocardiography (TOE) in anaesthetic practice is expanding. We evaluated the effect of a TOE perceptual and adaptive learning module (PALM) on first-yr anaesthesiology residents' performance, in diagnosing cardiac pathology by TOE. METHODS: First-yr residents were assigned to a group (n = 12) that used a TOE PALM or a control group that did not (n = 12). Both groups received a TOE pretest that measured their accuracy and response times...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28077020/relationship-between-18-f-flutemetamol-uptake-and-rbans-performance-in-non-demented-community-dwelling-older-adults
#7
Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Britney E Beardmore, Lance D Burrell, Kevin P Horn, Kelli M Rasmussen, Norman L Foster, Kevin Duff, John M Hoffman
OBJECTIVE: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been used extensively for clinical care and in research for patients with mild cognitive impairment and Alzheimer's disease (AD); however, relatively few studies have evaluated the relationship between RBANS performance and AD imaging biomarkers. The purpose of the current study was to evaluate the association between a relatively new amyloid positron emission tomography imaging biomarker and performance on the RBANS...
January 12, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28066747/complications-in-hip-arthroscopy
#8
Naoki Nakano, Vikas Khanduja
BACKGROUND: Recent developments in hip arthroscopic techniques and technology have made it possible in many cases to avoid open surgical dislocation for treating a variety of pathology in the hip. Although early reports suggest favourable results' using hip arthroscopy and it has been shown to be a relatively safe procedure, complications do exist and can sometimes lead to significant morbidity. METHODS: This is a review article. The aim of this manuscript is to present the most frequent and/or serious complications that could occur at or following hip arthroscopy and some guidelines to avoid these complications...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28062720/multimodal-characterization-of-older-apoe2-carriers-reveals-selective-reduction-of-amyloid-load
#9
Michel J Grothe, Sylvia Villeneuve, Martin Dyrba, David Bartrés-Faz, Miranka Wirth
OBJECTIVE: To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach. METHODS: Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI...
January 6, 2017: Neurology
https://www.readbyqxmd.com/read/28060686/-diabetes-knowledge-test-feasibility-in-portugal
#10
Constança Azevedo, Luiz Santiago
INTRODUCTION: Given the rising incidence of type 2 diabetes and taking into account that much of its control depends on the patient's attitude towards his illness, loomed the need to equip health professionals with capable tools to determine the educational needs of their patients, allowing a more personalized intervention to correct habits that could be harmful to the diabetics' health. OBJECTIVE: Verify the Diabetes Knowledge Test reliability in Portugal. Analysis of socio-demographic and pathologic variables' correlation with the number of correct answers in the test...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28055241/low-reporting-quality-of-the-meta-analyses-in-diagnostic-pathology
#11
Xulei Liu, Michael Kinzler, Jiangfan Yuan, Guozhong He, Lanjing Zhang
CONTEXT: -Little is known regarding the reporting quality of meta-analyses in diagnostic pathology. OBJECTIVE: -To compare reporting quality of meta-analyses in diagnostic pathology and medicine and to examine factors associated with reporting quality of diagnostic pathology meta-analyses. DESIGN: -Meta-analyses were identified in 12 major diagnostic pathology journals without specifying years and 4 major medicine journals in 2006 and 2011 using PubMed...
January 5, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28052315/deficits-in-temporal-processing-correlate-with-clinical-progression-in-huntington-s-disease
#12
P V Agostino, E M Gatto, M Cesarini, J L Etcheverry, A Sanguinetti, D A Golombek
OBJECTIVES: Precise temporal performance is crucial for several complex tasks. Time estimation in the second-to-minutes range-known as interval timing-involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic-glutamatergic pathways. Patients with Huntington's disease (HD) present deficits in cognitive and motor functions that require fine control of temporal processing. The objective of the present work was to assess temporal cognition through a peak-interval time (PI) production task in patients with HD and its potential correlation with the Unified Huntington's Disease Rating Scale (UHDRS)...
January 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28044304/review-of-hydatid-cyst-with-focus-on-cases-with-unusual-locations
#13
Sevinç Hallaç Keser, Ayşegül Selek, Dilek Ece, Cem Cahit Barişik, Sibel Şensu, Gonca Gül Geçmen, Selma Şengiz Erhan, Şermin Çoban Kökten, Nagehan Özdemir Barişik, Aylin Ege Gül
OBJECTIVE: This study has been conducted so as to contribute to health statistics of hydatid cyst by the data obtained from our clinic, and to discuss hydatid cysts in unusual locations. MATERIAL AND METHOD: Cases diagnosed as hydatid cyst at Dr. Lutfi Kirdar Kartal Research and Education Hospital Pathology Clinic between 2007 and 2015 have been evaluated based on criteria such as age, sex and location. RESULTS: A total of 364 cases, 209 females and 155 males, have been included in the study...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28041947/cognitive-reserve-and-cognitive-performance-of-patients-with-focal-frontal-lesions
#14
Sarah E MacPherson, Colm Healy, Michael Allerhand, Barbara Spanò, Carina Tudor-Sfetea, Mark White, Daniela Smirni, Tim Shallice, Edgar Chan, Marco Bozzali, Lisa Cipolotti
The Cognitive reserve (CR) hypothesis was put forward to account for the variability in cognitive performance of patients with similar degrees of brain pathology. Compensatory neural activity within the frontal lobes has often been associated with CR. For the first time we investigated the independent effects of two CR proxies, education and NART IQ, on measures of executive function, fluid intelligence, speed of information processing, verbal short term memory (vSTM), naming, and perception in a sample of 86 patients with focal, unilateral frontal lesions and 142 healthy controls...
December 29, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/28041321/spine-radiosurgery-lessons-learned-from-the-first-100-treatment-sessions
#15
Ran Harel, Raphael Pfeffer, Daphne Levin, Efrat Shekel, Dan Epstein, Lev Tsvang, Maoz Ben Ayun, Dror Alezra, Leor Zach
OBJECTIVE Local therapy to spine tumors has been shown to be effective in selected cases. Spinal radiosurgery (SRS) is an evolving radiotherapy regimen allowing for noninvasive, highly efficacious local treatment. The learning curve can compromise the results of any newly employed technology and should be studied to minimize its effects. In this paper the first 100 SRSs performed at several medical centers are presented and analyzed for the effects of the learning curve on outcome. METHODS A retrospective analysis was undertaken to evaluate data from patients treated with SRS at Sheba Medical Center and Assuta Medical Centers in the period from September 2011 to February 2016...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28035936/association-of-cancer-history-with-alzheimer-s-disease-dementia-and-neuropathology
#16
Mark Yarchoan, Bryan D James, Raj C Shah, Zoe Arvanitakis, Robert S Wilson, Julie Schneider, David A Bennett, Steven E Arnold
BACKGROUND: Cancer and Alzheimer's disease (AD) are common diseases of aging and share many risk factors. Surprisingly, however, epidemiologic data from several recent independent cohort studies suggest that there may be an inverse association between these diseases. OBJECTIVE: To determine the relationship between history of cancer and odds of dementia proximate to death and neuropathological indices of AD. METHODS: Using data from two separate clinical-pathologic cohort studies of aging and AD, the Religious Orders Study (ROS) and the Rush Memory and Aging Project (MAP), we compared odds of AD dementia proximate to death among participants with and without a history of cancer...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28027562/microcirculation-violations-of-the-conjunctiva-in-clean-up-workers-of-the-chornobyl-npp-accident
#17
P A Fedirko, N A Garkava
OBJECTIVE: Explore hemomicrocirculation changes after radiation exposure depending of irradiation dose in dynam ics. MATERIALS AND METHODS: The research conducted on 470 clean up workers of the Chornobyl NPP accident. After 10-15 years after radiation exposure examined 450 Chornobyl clean up workers in age of 28 to 65 years. The con trol group consisted of 110 industrial workers who had not a contact of IR. In 22 years after radiation exposure sep arately examined 20 randomly selected Chornobyl clean up workers accident...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/28018269/theory-of-mind-and-its-neuropsychological-and-quality-of-life-correlates-in-the-early-stages-of-amyotrophic-lateral-sclerosis
#18
Francesca Trojsi, Mattia Siciliano, Antonio Russo, Carla Passaniti, Cinzia Femiano, Teresa Ferrantino, Stefania De Liguoro, Luigi Lavorgna, Maria R Monsurrò, Gioacchino Tedeschi, Gabriella Santangelo
This study aims to explore the potential impairment of Theory of Mind (ToM; i.e., the ability to represent cognitive and affective mental states to both self and others) and the clinical, neuropsychological and Quality of Life (QoL) correlates of these cognitive abnormalities in the early stages of amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disease recently recognized as a part of the same clinical and pathological spectrum of frontotemporal lobar degeneration. Twenty-two consecutive, cognitively intact ALS patients, and 15 healthy controls, underwent assessment of executive, verbal comprehension, visuospatial, behavioral, and QoL measures, as well as of the ToM abilities by Emotion Attribution Task (EAT), Advanced Test of ToM (ATT), and Eyes Task (ET)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/28017511/out-of-hospital-cardiac-arrest-in-pregnancy-with-good-neurological-outcome-for-mother-and-infant
#19
S Pecher, E Williams
Cardiac arrest in pregnancy is rare (about 1:30000 pregnancies) and out-of-hospital cardiac arrests are even less frequent. Resuscitation of the pregnant mother is challenging and requires attention to the altered physiology, specific pathologies and the presence and well-being of the fetus. Once circulation has been restored, the lack of high-grade evidence regarding delivery of the baby and post-resuscitation care makes decision making complex. We present a case of out-of-hospital maternal cardiac arrest with successful resuscitation and good neurological outcome for mother and infant...
November 15, 2016: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28013426/examining-the-effect-of-self-explanation-on-cognitive-integration-of-basic-and-clinical-sciences-in-novices
#20
Kristina Lisk, Anne M R Agur, Nicole N Woods
Several studies have shown that cognitive integration of basic and clinical sciences supports diagnostic reasoning in novices; however, there has been limited exploration of the ways in which educators can translate this model of mental activity into sound instructional strategies. The use of self-explanation during learning has the potential to promote and support the development of integrated knowledge by encouraging novices to elaborate on the causal relationship between clinical features and basic science mechanisms...
December 24, 2016: Advances in Health Sciences Education: Theory and Practice
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