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https://www.readbyqxmd.com/read/28743173/improvement-and-persistent-disparities-in-completion-lymph-node-dissection-lessons-from-the-national-cancer-database
#1
Brian S Chu, Wima Koffi, Richard S Hoehn, Audrey Ertel, Shimul A Shah, Syed A Ahmad, Jeffrey J Sussman, Heather B Neuman, Daniel E Abbott
BACKGROUND: Completion lymph node dissection (CLND) is recommended for melanoma patients with positive sentinel lymph node biopsies (SLNB); however, 50% do not undergo CLND. We sought to determine CLND trends over time, and factors contributing to variability. METHODS: The NCDB was queried for patients undergoing wide local excision (WLE), with or without SLNB and CLND. Cohorts were created based on demographic/socioeconomic variables and era of treatment (Era 1: 2003-07, Era 2: 2008-12)...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28742788/computer-assisted-corrective-osteotomy-of-malunited-pediatric-radial-neck-fractures-three-dimensional-postoperative-accuracy-and-clinical-outcome
#2
Lizzy Weigelt, Philipp Fürnstahl, Andreas Schweizer
Neglected or incorrect treatment of pediatric radial neck fractures may lead to symptomatic malunions. Computer-assisted corrective osteotomies with patient-specific guides have been proposed as a promising technique for the reconstruction of malunited long bone deformities. The aim of this study was to evaluate the accuracy and clinical outcome of this technique in children with malunited fractures of the radial neck. Four children (two male, two female; mean age 12 (10-16) years) underwent computer-assisted closing wedge osteotomy of the radial neck...
July 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28741749/clinical-outcomes-after-local-field-conformal-reirradiation-of-patients-with-retropharyngeal-nodal-metastasis
#3
Courtney Pollard, Theresa P Nguyen, Sweet Ping Ng, Steven J Frank, Adam S Garden, Gary B Gunn, Clifton D Fuller, Beth M Beadle, William H Morrison, Shah J Shah, He Wang, Sam Tung, Conjun Wang, Lawrence D Ginsberg, Mark E Zafereo, Erich M Sturgis, Shirley Y Su, Ehab Y Hanna, David I Rosenthal, Jack Phan
BACKGROUND: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). METHODS: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. RESULTS: Thirteen patients (68%) had squamous cell carcinoma...
July 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28741723/analysis-of-the-incidence-and-factors-predictive-of-outcome-in-patients-with-head-and-neck-cancer-with-pulmonary-nodules
#4
Richard Green, Mark T Macmillan, Theofano Tikka, Lorna Bruce, John T Murchison, Iain J Nixon
BACKGROUND: The management of pulmonary nodules is challenging; unfortunately, little is known about the incidence and significance of pulmonary nodules in patients with head and neck cancer. METHODS: A review was conducted of 400 consecutive patients with head and neck cancer. Imaging was reviewed to identify the incidence of nodules and patient, tumor, and radiological factors associated with the risk of malignancy. RESULTS: Nodules were found in 58% of patients, with a malignant rate of 6%...
July 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28741683/a-clinical-trial-of-a-novel-emulsion-for-potential-use-as-a-saliva-substitute-in-patients-with-radiation-induced-xerostomia
#5
Olivia Apperley, Natalie Medlicott, Alison Rich, Sara Hanning, Maggie-Lee Huckabee
AIM: Researchers have recently developed a novel oily formulation for potential use as a saliva substitute for the treatment of dry mouth. The aim of this randomised, cross-over study was to compare this new formulation to a currently available saliva substitute and a control of water on measures of mastication, subjective feeling of oral dryness and product acceptability. METHODS: Forty participants treated with radiotherapy to the head and neck and experiencing xerostomia were invited to participate in the trial...
July 25, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28741444/mild-pulmonary-emphysema-a-risk-factor-for-interstitial-lung-disease-when-using-cetuximab-for-squamous-cell-carcinoma-of-the-head-and-neck
#6
Isaku Okamoto, Kiyoaki Tsukahara, Hiroki Sato, Ray Motohashi, Daisuke Yunaiyama, Akira Shimizu
BACKGROUND: Interstitial lung disease (ILD) is an occasionally fatal adverse event associated with cetuximab (Cmab) therapy. Our objective was to clarify to what degree pulmonary emphysema is a risk factor in the treatment of head and neck cancer with Cmab through a retrospective analysis. METHODS: Subjects were 116 patients who were administered Cmab for head and neck squamous cell carcinoma. The degree of pulmonary emphysema before initiating treatment with Cmab was visually assessed retrospectively, with scoring according to the Goddard classification used in Japanese chronic obstructive pulmonary disease (COPD) guidelines for chest computed tomography (CT)...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28741416/american-joint-committee-on-cancer-eighth-edition-changes-in-staging-criteria-implications-for-data-collection
#7
Anirudh Saraswathula, Michelle Chen, Serban Negoita, Vasu Divi
The American Joint Committee on Cancer, in the eighth edition of its cancer staging manual, makes a number of changes to improve survival predictions in human malignancy. In this commentary, we examine the national collection of data for head and neck cancer. We outline and review the major changes made in head and neck cancer staging, identify the key data elements that will need to be collected with the new edition's criteria, and discuss the institutional adjustments currently being made to data collection under the new guidelines to improve the quality of data in our national cancer databases...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28741411/intraoperative-evaluation-of-the-effects-of-femoral-component-offset-and-head-size-on-joint-stability-in-total-hip-arthroplasty
#8
Tetsuya Jinno, Daisuke Koga, Yoshinori Asou, Sadao Morita, Atsushi Okawa, Takeshi Muneta
PURPOSE: To evaluate intraoperatively the effects of femoral offset and head size on stability of the hip joints in total hip arthroplasty (THA) via posterior approach. METHODS: Thirty cementless THAs were included in this study. After acetabular shell and femoral broach fixation, trial reduction was repeated using a femoral neck (5- to 8-mm higher or standard offset) and a head (26 mm or 32 mm). To evaluate joint stability, range of internal rotation (IR) in hip flexion prior to posterior subluxation and range of external rotation (ER) in hip extension were measured...
January 1, 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28741409/foxp3-expression-in-lymph-node-metastases-in-patients-with-head-and-neck-cancer
#9
Mehtap Boduc, Marion Roessler, Robert Mandic, Christoph Netzer, Christian Güldner, Ute Walliczek-Dworschak, Boris A Stuck, Magis Mandapathil
INTRODUCTION: The prevalence and activity of regulatory T cells in patients with cancer correlates with poor prognosis. These cells are characterized by their expression of Forkhead box protein-3 (Foxp3). Squamous cell carcinoma is the most prevalent type of cancer in the head and neck region with overall poor survival rates, also due to early spread of metastatic cells. MATERIAL AND METHODS: Primary tumor specimens as well as lymph node specimens harvested during neck dissection of 65 patients with a diagnosis of HNSCC were subjected to immunohistochemical and H-score analysis of Foxp3 expression...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28741408/appropriateness-of-tympanostomy-tubes-in-the-boston-metropolitan-area-are-the-aao-hnsf-guidelines-being-met
#10
Amy L Hughes, David Roberson, Cassandra Bannos, Emily K Trudell, Louis Vernacchio
Introduction Otitis media (OM) is the most common reason children receive general anesthesia, with bilateral tympanostomy tube (TT) insertion the second most common surgery in children. Prior research suggests overuse of TT. As part of a project designed to improve appropriateness of OM referrals, we evaluated appropriateness of TT insertion in a patient cohort. Methods Patients younger than 9 years with initial otolaryngology (ORL) visits in academic and private office settings for OM from January 1, 2012, to August 31, 2013, were identified through claims database...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28741269/prevention-of-hpv-related-oral-cancer-by-dentists-assessing-the-opinion-of-dutch-dental-students
#11
Marcella R Poelman, Henk S Brand, Thymour Forouzanfar, Ellen M Daley, Derk H Jan Jager
The aim of this study is to assess dental students' opinions of the dentists' role in primary prevention of human papillomavirus (HPV)-related oral cancer using a cross-sectional web-based survey. A questionnaire, containing questions about knowledge of HPV and oral cancer, confidence in head and neck examination and role of the dentist in preventing HPV-related oral cancer, was sent to all students of the Academic Centre of Dentistry Amsterdam (n = 912). One hundred and twenty-six (n = 126) students completed the questionnaire...
July 24, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28740929/preserving-the-legacy-of-reirradiation-a-narrative-review-of-historical-publications
#12
REVIEW
Carsten Nieder, Johannes A Langendijk, Matthias Guckenberger, Anca L Grosu
PURPOSE: The purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960. METHODS AND MATERIALS: We chose the format of a narrative review because the historical articles are heterogeneous. No systematic extraction of baseline data, treatment details, or follow-up care was possible in many cases. RESULTS: Both hematological malignancies and solid tumors were treated with a second course of radiation therapy, and indications included local relapse, regional nodal recurrence, and second primary tumors developing in a previously treated region...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740928/magnetic-resonance-imaging-guided-reirradiation-of-recurrent-and-second-primary-head-and-neck-cancer
#13
Allen M Chen, Minsong Cao, Sophia Hsu, James Lamb, Argin Mikaeilian, Yingli Yang, Nzhde Agazaryan, Daniel A Low, Michael L Steinberg
PURPOSE: To report a single-institutional experience using magnetic resonance imaging (MRI) guided radiation therapy for the reirradiation of recurrent and second cancers of the head and neck. METHODS AND MATERIALS: Between October 2014 and August 2016, 13 consecutive patients with recurrent or new primary cancers of the head and neck that occurred in a previously irradiated field were prospectively enrolled in an institutional registry trial to investigate the feasibility and efficacy of MRI guided radiation therapy using a 0...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740895/using-low-dose-radiation-to-potentiate-the-effect-of-induction-chemotherapy-in-head-and-neck-cancer-results-of-a-prospective-phase-2-trial
#14
Susanne M Arnold, Mahesh Kudrimoti, Emily V Dressler, John F Gleason, Natalie L Silver, William F Regine, Joseph Valentino
PURPOSE: Low-dose fractionated radiation therapy (LDFRT) induces effective cell killing through hyperradiation sensitivity and potentiates effects of chemotherapy. We report our second investigation of LDFRT as a potentiator of the chemotherapeutic effect of induction carboplatin and paclitaxel in locally advanced squamous cell cancer of the head and neck (SCCHN). EXPERIMENTAL DESIGN: Two cycles of induction therapy were given every 21 days: paclitaxel (75 mg/m(2)) on days 1, 8, and 15; carboplatin (area under the curve 6) day 1; and LDFRT 50 cGy fractions (2 each on days 1, 2, 8, and 15)...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740894/postoperative-radiation-therapy-is-associated-with-a-reduced-risk-of-local-recurrence-among-low-risk-merkel-cell-carcinomas-of-the-head-and-neck
#15
Seesha R Takagishi, Tessa E Marx, Christopher Lewis, Erica S Tarabadkar, Ilsa D Juhlin, Astrid Blom, Jayasri G Iyer, Jay J Liao, Yolanda D Tseng, Teresa Fu, Paul Nghiem, Upendra Parvathaneni
PURPOSE: Merkel cell carcinoma (MCC) is a rare and often aggressive skin cancer. Typically, surgery is the primary treatment. Postoperative radiation therapy (PORT) is often recommended to improve local control. It is unclear whether PORT is indicated in patients with favorable Stage IA head and neck (HN) MCC. METHODS AND MATERIALS: We conducted a retrospective analysis of 46 low-risk HN MCC cases treated between 2006 and 2015. Inclusion criteria were defined as a primary tumor size of ≤ 2 cm, negative pathological margins, negative sentinel lymph node biopsy, and no immunosuppression...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740778/takotsubo-cardiomyopathy-after-head-and-neck-reconstructive-surgery
#16
Masanori Mori, Hayato Nagashima, Satoshi Akazawa, Noriko Saegusa, Yuichi Ichikawa, Kei Iida, Kotaro Yoshimura, Masahiro Nakagawa
Takotsubo cardiomyopathy (TCM) is a form of transient heart failure that clinically mimics acute coronary syndrome and is characterized by left ventricular wall motion abnormalities. The pathophysiology of TCM is not well established. TCM is often preceded by emotional or physical stress and may occur after surgery. We present 3 cases of TCM occurring after head and neck reconstructive surgery. Echocardiography plays a central role in the diagnosis of TCM. Left ventricular wall motion abnormalities extend beyond the territory of a single coronary artery...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740764/multiple-free-flap-reconstructions-of-head-and-neck-defects-due-to-oral-cancer
#17
Yumi Mochizuki, Hiroyuki Harada, Hiroaki Shimamoto, Hirofumi Tomioka, Hideaki Hirai
OBJECTIVE: We studied complications following multiple free flap reconstructions in the head and neck. METHODS: In this cohort, 26 patients (14 men and 12 women) who underwent multiple microvascular free flap reconstructions were included in the study. The reasons for secondary reconstruction were recurrence of tumor (12 cases), necrosis of transferred skin and/or bone (6 cases), reconstruction plate fracture or exposure (4 cases), and others (4 cases). A third reconstruction in 4 cases and a fourth reconstruction in 1 case were performed...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740564/can-diffusion-weighted-imaging-aid-in-differentiating-benign-from-malignant-sinonasal-masses-a-useful-adjunct
#18
Abanti Das, Ashu S Bhalla, Raju Sharma, Atin Kumar, Alok Thakar, Sreenivas M Vishnubhatla, Mehar C Sharma, Suresh C Sharma
BACKGROUND: To evaluate the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) values at 3 Tesla in characterizing sinonasal masses. MATERIAL/METHODS: After ethical clearance, 79 treatment naive patients with head and neck masses underwent magnetic resonance imaging (MRI), including DWI at 3 Tesla using the following b values - 0, 500 and 1000 s/mm(2). Thirty-one patients were found to have sinonasal tumours and were subsequently analysed...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28739517/novel-use-of-the-leksell-gamma-frame-for-stereotactic-biopsy-of-posterior-fossa-lesions-technical-note
#19
Shiro Horisawa, Hiroshi Nakano, Takakzu Kawamata, Takaomi Taira
BACKGROUND: Stereotactic transcerebellar biopsies of brainstem tumors have often been reported. The Leksell frame or Cosman-Roberts-Wells frame is often used in transcerebellar approaches. However, to access lesions via the cerebellum, these frames should be secured as inferiorly on the cranium as possible, which can require exaggerated neck flexion and limit the flexible trajectory to the target. To overcome these disadvantages, we have devised a new way to use the Leksell frame for transcerebellar approaches...
July 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28739384/tumor-heterogeneity-determined-with-a-%C3%AE-h2ax-foci-assay-a-study-in-human-head-and-neck-squamous-cell-carcinoma-hhnscc-models
#20
Treewut Rassamegevanon, Steffen Löck, Ursula Range, Mechthild Krause, Michael Baumann, Cläre von Neubeck
PURPOSE: This study aimed to analyze the intra-tumoral heterogeneity of γH2AX foci in tumor specimens following ex vivo radiation to evaluate the potential of γH2AX foci as predictors for radiosensitivity. MATERIAL AND METHODS: γH2AX foci were quantified in tumor specimens of 3hHNSCC tumor models with known differences in radiosensitivity after reoxygenation in culture medium (10h, 24h), single dose exposure (0Gy, 4Gy), and fixation 24h post-irradiation. Multiple, equally treated samples of the same tumor were analyzed for foci, normalized and fitted in a linear mixed-effects model...
July 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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