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https://www.readbyqxmd.com/read/28328214/proton-conductance-of-a-superior-water-stable-metal-organic-framework-and-its-composite-membrane-with-poly-vinylidene-fluoride
#1
Hong-Bin Luo, Mei Wang, Shao-Xian Liu, Chen Xue, Zheng-Fang Tian, Yang Zou, Xiao-Ming Ren
Proton-exchange membranes (PEMs) as separators have important technological applications in electrochemical devices, including fuel cells, electrochemical sensors, electrochemical reactors, and electrochromic displays. The composite membrane of a proton-conducting metal-organic framework (MOF) and an organic polymer combines the unique physical and chemical nature of the polymer and the high proton conductivity of the MOF, bringing together the best of both components to potentially fabricate high-performance PEMs...
March 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28327716/chemo-photodynamic-combined-gene-therapy-and-dual-modal-cancer-imaging-achieved-by-ph-responsive-alginate-chitosan-multilayer-modified-magnetic-mesoporous-silica-nanocomposites
#2
Hong Yang, Yin Chen, Zhongyuan Chen, Yue Geng, Xiaoxue Xie, Xue Shen, Tingting Li, Shun Li, Chunhui Wu, Yiyao Liu
Multifunctional theranostics have offered some interesting new opportunities for cancer therapy and diagnosis in the last decade. Herein, magnetic mesoporous silica nanoparticles (M-MSNs) were designed and synthesized, then the photosensitizer chlorin e6 (Ce6) and antitumor drug doxorubicin (Dox) were adsorbed onto the M-MSNs. Biocompatible alginate/chitosan polyelectrolyte multilayers (PEM) were assembled on the M-MSNs to achieve a pH-responsive drug delivery system and adsorb P-gp shRNA for reversing the multidrug resistance...
March 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28319811/protein-epitope-mimetic-macrocycles-as-biopharmaceuticals
#3
REVIEW
Anatol Luther, Kerstin Moehle, Eric Chevalier, Glenn Dale, Daniel Obrecht
Fully synthetic medium-sized macrocyclic peptides mimicking the key β-hairpin and α-helical protein epitopes relevant in many protein-protein interactions have emerged as a novel class of drugs with the potential to fill an important gap between small molecules and proteins. Conformationally stabilized macrocyclic scaffolds represent ideal templates for medicinal chemists to incorporate bioactive peptide and protein pharmacophores in order to generate novel drugs to treat diseases with high unmet medical need...
March 5, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28303160/cervical-rotatory-manipulation-decreases-uniaxial-tensile-properties-of-rabbit-atherosclerotic-internal-carotid-artery
#4
Shaoqun Zhang, Ji Qi, Lei Zhang, Chao Chen, Shubhro Mondal, Kaike Ping, Yili Chen, Yikai Li
Objective. To investigate the effects of one of the Chinese massage therapies, cervical rotatory manipulation (CRM), on uniaxial tensile properties of rabbit atherosclerotic internal carotid artery (ICA). Methods. 40 male purebred New Zealand white rabbits were randomly divided into CRM-Model group, Non-CRM-Model group, CRM-Normal group, and Non-CRM-Normal group. After modeling (atherosclerotic model) and intervention (CRM or Non-CRM), uniaxial tensile tests were performed on the ICAs to assess the differences in tensile mechanical properties between the four groups...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28294119/low-cost-and-durable-bipolar-plates-for-proton-exchange-membrane-electrolyzers
#5
P Lettenmeier, R Wang, R Abouatallah, B Saruhan, O Freitag, P Gazdzicki, T Morawietz, R Hiesgen, A S Gago, K A Friedrich
Cost reduction and high efficiency are the mayor challenges for sustainable H2 production via proton exchange membrane (PEM) electrolysis. Titanium-based components such as bipolar plates (BPP) have the largest contribution to the capital cost. This work proposes the use of stainless steel BPPs coated with Nb and Ti by magnetron sputtering physical vapor deposition (PVD) and vacuum plasma spraying (VPS), respectively. The physical properties of the coatings are thoroughly characterized by scanning electron, atomic force microscopies (SEM, AFM); and X-ray diffraction, photoelectron spectroscopies (XRD, XPS)...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28291151/research-interest-in-pediatric-emergency-medicine-fellows
#6
Kenneth A Michelson, Lise E Nigrovic, Joshua Nagler, Constance M McAneney, Rakesh D Mistry
OBJECTIVE: Factors predictive of research career interest among pediatric emergency medicine (PEM) fellows are not known. We sought to determine the prevalence and determinants of interest in research careers among PEM fellows. METHODS: We performed an electronically distributed national survey of current PEM fellows. We assessed demographics, barriers to successful research, and beliefs about research using 4-point ordinal scales. The primary outcome was the fellow-reported predicted percentage of time devoted to clinical research 5 years after graduation...
March 13, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28286864/in-vivo-expansion-of-melanoma-specific-t-cells-using-microneedle-arrays-coated-with-immune-polyelectrolyte-multilayers
#7
Qin Zeng, Joshua M Gammon, Lisa H Tostanoski, Yu-Chieh Chiu, Christopher M Jewell
Microneedles (MNs) are micron-scale polymeric or metallic structures that offer distinct advantages for vaccines by efficiently targeting skin-resident immune cells, eliminating injection-associated pain, and improving patient compliance. These advantages, along with recent studies showing therapeutic benefits achieved using traditional intradermal injections in human cancer patients, suggest MN delivery might enhance cancer vaccines and immunotherapies. We recently developed a new class of polyelectrolyte multilayers based on the self-assembly of model peptide antigens and molecular toll-like receptor agonists (TLRa) into ultrathin, conformal coatings...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28282609/high-efficient-acetate-production-from-carbon-dioxide-using-a-bioanode-microbial-electrosynthesis-system-with-bipolar-membrane
#8
Yinbo Xiang, Guangli Liu, Renduo Zhang, Yaobin Lu, Haiping Luo
The aim of this study was to develop an efficient bioanode microbial electrosynthesis system (MES) to convert carbon dioxide into acetate using bioenergy from the wastewater. The bioanode MESs were constructed using proton exchange membrane (PEM) and bipolar membrane (BPM) as separator, respectively, and operated under different voltages (i.e., 0.8, 1.0, 1.2, and 1.4V). Since BPM could dissociate H2O into H(+) and OH(-) in situ to buffer the pH change in the chambers, the BPM-MES achieved 238% improvement in cathodic acetate production rate, 45% increase in anodic substrate removal efficiency, and more than five times enhancement in current output, as compared to the PEM-MES...
February 27, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28269265/promotion-and-guidance-of-neural-network-formation-on-su-8-photoresist-microchannels-adjusted-with-multilayer-films
#9
Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei
Induction of neural stem/progenitor cells (NSPCs) and establishment of neural network are important issues on neural engineering. In this work, a platform was designed to control and evaluate the differentiation of NSPCs, neurite direction, and to promote the neurite outgrowth. Polyelectrolyte multilayer (PEM) films provide surface properties by and have been used to regulate NSPCs differentiation in our previous study. Herein, a culture platform composed of SU-8 microchannel and PEM films was designed to achieve the goal of promoting NSPCs differentiation and to evaluate the effect of PEM films on the guidance of neural network formation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266879/measuring-participation-of-children-and-environmental-factors-at-home-school-and-in-community-construct-validation-of-the-korean-pem-cy
#10
Yunwha Jeong, Mary Law, Paul Stratford, Carol DeMatteo, Cheryl Missiuna
AIMS: To determine construct validity of the Korean Participation and Environment Measure for Children and Youth (KPEM-CY) in South Korea. METHODS: A total of 184 parents of children with (n = 80) and without disabilities (n = 104) aged 5 to 13 years completed the KPEM-CY. Construct validity was analyzed by assessing differences in the participation and environment scores for children with and without disabilities across age and gender. RESULTS: Validity of the KPEM-CY was supported by significant differences in participation and environmental factors for subgroups (p < ...
March 7, 2017: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/28265414/pesticide-metabolite-and-oxidative-stress-in-male-farmers-exposed-to-pesticide
#11
Kang Myoung Lee, Sang-Yoo Park, Kyungsuk Lee, Sung-Soo Oh, Sang Baek Ko
BACKGROUND: The objective of this study was to measure malondialdehyde (MDA) and isoprostane which has been used as an index of lipid injury, 8-hydroxy-2'-deoxyguanosine (8-OHdG), which has been used as an index of DNA damage, and dialkyl-phosphate (DAP), which has been used to quantify pesticide exposure, and to investigate the relationship between pesticide exposure and oxidative stress. METHODS: This study was a cross-sectional study that evaluated 84 male farmers exposure to pesticide...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28263552/polyelectrolyte-layer-by-layer-assembly-on-organic-electrochemical-transistors
#12
Anna-Maria Pappa, Sahika Inal, Kirsty Roy, Yi Zhang, Charalampos Pitsalidis, Adel Hama, Jolien Pas, George G Malliaras, Roisin M Owens
Oppositely charged polyelectrolyte multilayers (PEMs) were built-up in a layer-by-layer (LbL) assembly on top of the conducting polymer channel of an organic electrochemical transistor (OECT), aiming to combine the advantages of well-established PEMs with a high performance electronic transducer. The multilayered film is a model system to investigate the impact of biofunctionalization on the operation of OECTs comprising a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) film as the active layer...
March 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28257183/hydrocarbon-based-polymer-electrolyte-membranes-importance-of-morphology-on-ion-transport-and-membrane-stability
#13
Dong Won Shin, Michael D Guiver, Young Moo Lee
A fundamental understanding of polymer microstructure is important in order to design novel polymer electrolyte membranes (PEMs) with excellent electrochemical performance and stabilities. Hydrocarbon-based polymers have distinct microstructure according to their chemical structure. The ionic clusters and/or channels play a critical role in PEMs, affecting ion conductivity and water transport, especially at medium temperature and low relative humidity (RH). In addition, physical properties such as water uptake and dimensional swelling behavior depend strongly on polymer morphology...
March 3, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28253360/the-effect-of-paclitaxel-eluting-covered-metal-stents-versus-covered-metal-stents-in-a-rabbit-esophageal-squamous-carcinoma-model
#14
Yin Zhang, Limei Ma, Jin Huang, Jinquan Shuang, Jianping Chen, Zhining Fan
BACKGROUND: The use of self-expanding metallic stents (SEMSs) is the current treatment of choice for malignant gastrointestinal obstructions. However, these stents can promote only drainage and have no antitumor effect. Some studies have reported that drug-eluting SEMSs may have tumor inhibition potential. The aim of this study was to evaluate the efficiency and safety of paclitaxel-eluting SEMSs (PEMSs) in rabbit esophageal cancer models. MATERIALS AND METHODS: A PEMS was covered with a paclitaxel-incorporated membrane, in which the concentration of paclitaxel was 10% (wt/vol)...
2017: PloS One
https://www.readbyqxmd.com/read/28251983/the-respective-effect-of-under-rib-convection-and-pressure-drop-of-flow-fields-on-the-performance-of-pem-fuel-cells
#15
Chao Wang, Qinglei Zhang, Shuiyun Shen, Xiaohui Yan, Fengjuan Zhu, Xiaojing Cheng, Junliang Zhang
The flow field configuration plays an important role on the performance of proton exchange membrane fuel cells (PEMFCs). For instance, channel/rib width and total channel cross-sectional area determine the under-rib convection and pressure drop respectively, both of which directly influence the water removal, in turn affecting the oxygen supply and cathodic oxygen reduction reaction. In this study, effects of under-rib convection and pressure drop on cell performance are investigated experimentally and numerically by adjusting the channel/rib width and channel cross-sectional area of flow fields...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28244699/serum-zinc-evolution-in-dysphagic-patients-that-underwent-endoscopic-gastrostomy-for-long-term-enteral-feeding
#16
Carla Adriana Santos, Jorge Fonseca, Maria Teresa Martins Lopes, Elisabete Carolino, António Sousa Guerreiro
BACKGROUND AND OBJECTIVES: Patients undergoing endoscopic gastrostomy (PEG) present with protein-energy malnutrition (PEM) but little is known about zinc status. Our aim was to evaluate serum zinc, its relationship with serum proteins and with the nature of the underlying disorder, during the first 3 months of PEG feeding. METHODS AND STUDY DESIGN: Prospective observational study during a 3-month period after gastrostomy. Data was collected at initial PEG procedure (T0), after 4 (T1) and 12 weeks (T3)...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28240241/calcium-pre-conditioning-substitution-enhances-viability-and-glucose-sensitivity-of-pancreatic-beta-cells-encapsulated-using-polyelectrolyte-multilayer-coating-method
#17
Niusha Nikravesh, Sophie C Cox, Gurpreet Birdi, Richard L Williams, Liam M Grover
Type I diabetics are dependent on daily insulin injections. A therapy capable of immunoisolating pancreatic beta-cells and providing normoglycaemia is an alternative since it would avoid the late complications associated with insulin use. Here, 3D-concave agarose micro-wells were used to culture robust pancreatic MIN-6 cell spheroids within 24 hours that were shown to exhibit cell-cell contact and uniform size (201 ± 2 μm). A polyelectrolyte multilayer (PEM) approach using alginate and poly-l-lysine was employed to coat cell spheroids...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28227499/promotion-and-guidance-of-neural-network-formation-on-su-8-photoresist-microchannels-adjusted-with-multilayer-films
#18
Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei, Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei, Yung-Chiang Liu, I-Chi Lee, Kin-Fong Lei
Induction of neural stem/progenitor cells (NSPCs) and establishment of neural network are important issues on neural engineering. In this work, a platform was designed to control and evaluate the differentiation of NSPCs, neurite direction, and to promote the neurite outgrowth. Polyelectrolyte multilayer (PEM) films provide surface properties by and have been used to regulate NSPCs differentiation in our previous study. Herein, a culture platform composed of SU-8 microchannel and PEM films was designed to achieve the goal of promoting NSPCs differentiation and to evaluate the effect of PEM films on the guidance of neural network formation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221865/cost-effectiveness-of-immune-checkpoint-inhibition-in-braf-wild-type-advanced-melanoma
#19
Christine G Kohn, Simon B Zeichner, Qiushi Chen, Alberto J Montero, Daniel A Goldstein, Christopher R Flowers
Purpose Patients who are diagnosed with stage IV metastatic melanoma have an estimated 5-year relative survival rate of only 17%. Randomized controlled trials of recent US Food and Drug Administration-approved immune checkpoint inhibitors-pembrolizumab (PEM), nivolumab (NIVO), and ipilumumab (IPI)-demonstrate improved patient outcomes, but the optimal treatment sequence in patients with BRAF wild-type metastatic melanoma remains unclear. To inform policy makers about the value of these treatments, we developed a Markov model to compare the cost-effectiveness of different strategies for sequencing novel agents for the treatment of advanced melanoma...
February 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28198385/dual-electrophoresis-detection-system-for-rapid-and-sensitive-immunoassays-with-nanoparticle-signal-amplification
#20
Fangfang Zhang, Junjie Ma, Junji Watanabe, Jinlong Tang, Huiyu Liu, Heyun Shen
An electrophoretic technique was combined with an enzyme-linked immunosorbent assay (ELISA) system to achieve a rapid and sensitive immunoassay. A cellulose acetate filter modified with polyelectrolyte multilayer (PEM) was used as a solid substrate for three-dimensional antigen-antibody reactions. A dual electrophoresis process was used to induce directional migration and local condensation of antigens and antibodies at the solid substrate, avoiding the long diffusion times associated with antigen-antibody reactions in conventional ELISAs...
February 15, 2017: Scientific Reports
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