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https://www.readbyqxmd.com/read/28221865/cost-effectiveness-of-immune-checkpoint-inhibition-in-braf-wild-type-advanced-melanoma
#1
Christine G Kohn, Simon B Zeichner, Qiushi Chen, Alberto J Montero, Daniel A Goldstein, Christopher R Flowers
Purpose Patients who are diagnosed with stage IV metastatic melanoma have an estimated 5-year relative survival rate of only 17%. Randomized controlled trials of recent US Food and Drug Administration-approved immune checkpoint inhibitors-pembrolizumab (PEM), nivolumab (NIVO), and ipilumumab (IPI)-demonstrate improved patient outcomes, but the optimal treatment sequence in patients with BRAF wild-type metastatic melanoma remains unclear. To inform policy makers about the value of these treatments, we developed a Markov model to compare the cost-effectiveness of different strategies for sequencing novel agents for the treatment of advanced melanoma...
February 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28198385/dual-electrophoresis-detection-system-for-rapid-and-sensitive-immunoassays-with-nanoparticle-signal-amplification
#2
Fangfang Zhang, Junjie Ma, Junji Watanabe, Jinlong Tang, Huiyu Liu, Heyun Shen
An electrophoretic technique was combined with an enzyme-linked immunosorbent assay (ELISA) system to achieve a rapid and sensitive immunoassay. A cellulose acetate filter modified with polyelectrolyte multilayer (PEM) was used as a solid substrate for three-dimensional antigen-antibody reactions. A dual electrophoresis process was used to induce directional migration and local condensation of antigens and antibodies at the solid substrate, avoiding the long diffusion times associated with antigen-antibody reactions in conventional ELISAs...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196435/dynamic-assessment-of-the-wrist-after-total-wrist-arthroplasty
#3
H P Singh, D Bhattacharjee, J J Dias, I Trail
Our aim was to assess the outcome in patients with total wrist arthroplasty performed for end stage wrist osteoarthritis. We analysed the ranges of motion of operated and un-operated wrists using a flexible electrogoniometer during the Sollerman hand function test. We assessed grip strength with a digital dynamometer and completed patient reported outcome scores more than one year post-operatively. We reviewed 12 patients with a mean age of 64 (range 48-82) years. The flexion-extension arc was 72% and radioulnar deviation arc was 53% of the un-operated side but the total range of motion (area of circumduction) was 43% of the un-operated side and only 20% of the circumduction in age and gender-matched normal volunteers...
February 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28193634/purified-streptococcus-pneumoniae-endopeptidase-o-pepo-enhances-particle-uptake-by-macrophages-in-a-tlr2-and-mir-155-dependent-manner
#4
Hua Yao, Hong Zhang, Kai Lan, Hong Wang, Yufeng Su, Dagen Li, Zhixin Song, Fang Cui, Yibing Yin, Xuemei Zhang
Insights into the host-microbial virulence factors interaction, especially the immune-signaling mechanisms, could provide novel prevention and treatment options for pneumococcal diseases. Streptococcus pneumoniae endopeptidase O (PepO) is a newly discovered and ubiquitously expressed pneumococcal virulence protein. A PepO-mutant strain showed impaired adherence to and invasion of host cells compared with their isogenic wild-type strains. It is still unknown whether PepO is involved in host defense response against pneumococcal infection...
February 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28186520/quantifying-and-controlling-the-cation-uptake-upon-hydrated-ionic-liquid-induced-swelling-of-polyelectrolyte-multilayers
#5
N Parveen, M Schönhoff
Controlling the uptake of specific ions in polyelectrolyte multilayers is of interest for various fields of application. Here, we quantify the amount of cation of an ionic liquid, namely 1,3-bis(cyanomethyl)imidazolium chloride, incorporated into polyelectrolyte multilayers upon contact with an ionic liquid solution. The ion partition equilibrium is determined depending on concentration in solution, employing attenuated total reflection infrared spectroscopy. Generating an excess charge in multilayers by post-preparative manipulation of their charge balance, one can control the incorporated amount...
February 10, 2017: Soft Matter
https://www.readbyqxmd.com/read/28185792/randomized-phase-iii-study-of-docetaxel-plus-cisplatin-versus-pemetrexed-plus-cisplatin-as-first-line-treatment-of-nonsquamous-non-small-cell-lung-cancer-a-trail-trial
#6
Cheol-Kyu Park, In-Jae Oh, Kyu-Sik Kim, Yoo-Duk Choi, Tae-Won Jang, Youn-Seup Kim, Kwan-Ho Lee, Kyeong-Cheol Shin, Chi Young Jung, Sei-Hoon Yang, Jeong-Seon Ryu, Seung-Hun Jang, Seung-Soo Yoo, Suk-Joong Yong, Kye Young Lee, Kwang-Ho In, Min-Ki Lee, Young-Chul Kim
INTRODUCTION: To date, no prospective phase III trials have directly compared the efficacy of pemetrexed plus cisplatin (Pem-Cis) with docetaxel plus cisplatin (Doc-Cis) in patients with nonsquamous non-small-cell lung cancer. MATERIALS AND METHODS: A total of 148 chemotherapy-naive patients lacking driver mutations were randomized into 21-day regimens of cisplatin 70 mg/m(2) with either docetaxel 60 mg/m(2) (n = 71) or pemetrexed 500 mg/m(2) (n = 77) for ≤ 4 cycles...
January 11, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28179168/parallel-changes-in-cortical-neuron-biochemistry-and-motor-function-in-protein-energy-malnourished-adult-rats
#7
Mariam Alaverdashvili, Mark J Hackett, Sally Caine, Phyllis G Paterson
While protein-energy malnutrition in the adult has been reported to induce motor abnormalities and exaggerate motor deficits caused by stroke, it is not known if alterations in mature cortical neurons contribute to the functional deficits. Therefore, we explored if PEM in adult rats provoked changes in the biochemical profile of neurons in the forelimb and hindlimb regions of the motor cortex. Fourier transform infrared spectroscopic imaging using a synchrotron generated light source revealed for the first time altered lipid composition in neurons and subcellular domains (cytosol and nuclei) in a cortical layer and region-specific manner...
February 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/28174245/eccentric-position-of-the-germinal-vesicle-and-cortical-flow-during-oocyte-maturation-specify-the-animal-vegetal-axis-of-ascidian-embryos
#8
Masumi Tokuhisa, Miyuki Muto, Hiroki Nishida
The animal-vegetal (A-V) axis is already set in unfertilized eggs. It plays crucial roles to coordinate germ-layer formation. However, how the A-V axis is set has not been well studied. In ascidians, unfertilized eggs are already polarized along the axis in terms of cellular components. The polarization occurs during oocyte maturation. Oocytes within the gonad have the germinal vesicle (GV) close to the future animal pole. When the GVs of full-grown oocytes were experimentally translocated to the opposite pole by centrifugal force, every aspect that designates A-V polarity was reversed in the eggs and embryos...
February 7, 2017: Development
https://www.readbyqxmd.com/read/28166626/in-use-nox-emissions-from-diesel-and-liquefied-natural-gas-refuse-trucks-equipped-with-scr-and-twc-respectively
#9
Chandan Misra, Chris Ruehl, John Francis Collins, Don Chernich, Jorn Herner
The California Air Resources Board (ARB) and the City of Sacramento undertook this study to characterize the in-use emissions from model year (MY) 2010 or newer diesel, liquefied natural gas (LNG) and hydraulic hybrid diesel engines during real-world refuse truck operation. Emissions from five trucks: two diesels equipped with selective catalytic reduction (SCR), two LNG's equipped with three-way catalyst (TWC) and one hydraulic hybrid diesel equipped with SCR were measured using a portable emissions measurement system (PEMS) in the Sacramento area...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28146012/identification-of-optic-nerve-swelling-using-point-of-care-ocular-ultrasound-in-children
#10
Ronald F Marchese, Rakesh D Mistry, Gil Binenbaum, Grant T Liu, Richard J Scarfone, Ashley L Woodford, Aaron E Chen
OBJECTIVE: The aim of this study was to determine the feasibility and accuracy of point-of-care (POC) ocular ultrasound (US) when performed by a pediatric emergency medicine (PEM) physician to detect optic nerve abnormalities concerning for swelling, as compared with the fundus examination performed by an ophthalmologist. METHODS: This was a single-center, prospective cohort pilot study of children aged 12 months to 18 years who required optic disc evaluation by an ophthalmologist...
January 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28117762/composite-hydrogels-with-engineered-microdomains-for-optical-glucose-sensing-at-low-oxygen-conditions
#11
Lindsey R Bornhoeft, Aniket Biswas, Michael J McShane
There is a growing need for advanced tools that enable frequent monitoring of biomarkers for precision medicine. In this work, we present a composite hydrogel-based system providing real-time optical bioanalyte monitoring. The responsive material, alginate-in-alginate (AnA), is comprised of an alginate hydrogel with embedded bioactive, nanofilm-coated phosphorescent microdomains; palladium tetracarboxyphenylporphyrin serves as an optical indicator, glucose oxidase as a model enzyme, and layer-by-layer deposited polyelectrolyte multilayers (PEMs) as the diffusion barrier...
January 22, 2017: Biosensors
https://www.readbyqxmd.com/read/28114848/improvement-in-patient-reported-outcomes-of-varicose-veins-following-treatment-with-polidocanol-endovenous-microfoam
#12
Brajesh K Lal, Rajiv Mallick, David Wright
Objective To evaluate the relationship between patient-reported symptoms and functional and psychological impact of varicose veins following treatment with polidocanol endovenous microfoam (PEM) 1%. Methods Data were pooled from two randomized trials on VV treatment. Wilson-Cleary health outcomes path model was applied to evaluate impact of VVSymQ® symptom score improvement on modified VEINES-QOL/Sym functional and psychological scores. Change scores were evaluated for (i) PEM 1% versus placebo groups and (ii) quartiles of symptom improvement...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28105824/fabrication-method-for-laboratory-scale-high-performance-membrane-electrode-assemblies-for-fuel-cells
#13
Megan B Sassin, Yannick Garsany, Benjamin D Gould, Karen E Swider-Lyons
Custom catalyst-coated membranes (CCMs) and membrane electrode assemblies (MEAs) are necessary for the evaluation of advanced electrocatalysts, gas diffusion media (GDM), ionomers, polymer electrolyte membranes (PEMs), and electrode structures designed for use in next-generation fuel cells, electrolyzers, or flow batteries. This Feature provides a reliable and reproducible fabrication protocol for laboratory scale (10 cm(2)) fuel cells based on ultrasonic spray deposition of a standard Pt/carbon electrocatalyst directly onto a perfluorosulfonic acid PEM...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28105156/establishment-of-a-first-line-second-line-treatment-model-for-human-pulmonary-adenocarcinoma
#14
Lining Wang, Yu Wang, Qi Guan, Yong Liu, Tianyi He, Jiaru Wang
Lung cancer is one of the most prevalent types of cancer in the world. Surgery, chemotherapy and radiotherapy are used clinically as treatments for numerous cancers. Due to the appearance of drug resistance, the remission rate is limited to 40-50%. Docetaxel and pemetrexed are two drugs commonly used, and their effects in single-phase cell culture are well known. From the pharmacological point of view, it appears rational to hypothesize that sequential therapy effects can show better outcomes compared with traditional single-phase experiments...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28102938/low-energy-catalytic-electrolysis-for-simultaneously-hydrogen-evolution-and-lignin-depolymerization
#15
Xu Du, Wei Liu, Zhe Zhang, Arie Mulyadi, Alex Brittain, Jian Gong, Yulin Deng
Hereby we present a novel proton exchange membrane (PEM) electrolysis process in which lignin was used as the hydrogen source at anode for hydrogen production. Either polyoxometalate (POM) or FeCl3 was used as the catalysts and charge transfer agents in anode. Over 90% Faraday efficiency was achieved. In a thermal insulation reactor, the heat energy can be maintained at a very low stage for continuous operation. Compared to the best alkaline water electrolysis reported in literature, the electrical energy consumption could be 40% lower with novel lignin electrolysis method...
January 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28099369/the-cessation-of-anti-pd-1-antibodies-of-complete-responders-in-metastatic-melanoma
#16
Rahul Ladwa, Victoria Atkinson
The optimal duration of PD-1 antibodies for metastatic melanoma is unknown. In previous trials, there has been the potential to cease therapy if the patient achieves a complete response (CR). We aimed to assess the outcomes of patients who had ceased anti-PD-1 antibodies in this setting. A retrospective review was carried out of CR to PD-1-based therapy across two institutions. Patients were from the Pembrolizumab Named Patient Program (PEM NPP), Nivolumab monotherapy (NIVO), and reimbursed Pembrolizumab (r PEM)...
January 17, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28086790/rna-sequencing-for-global-gene-expression-associated-with-muscle-growth-in-a-single-male-modern-broiler-line-compared-to-a-foundational-barred-plymouth-rock-chicken-line
#17
Byung-Whi Kong, Nicholas Hudson, Dongwon Seo, Seok Lee, Bhuwan Khatri, Kentu Lassiter, Devin Cook, Alissa Piekarski, Sami Dridi, Nicholas Anthony, Walter Bottje
BACKGROUND: Modern broiler chickens exhibit very rapid growth and high feed efficiency compared to unselected chicken breeds. The improved production efficiency in modern broiler chickens was achieved by the intensive genetic selection for meat production. This study was designed to investigate the genetic alterations accumulated in modern broiler breeder lines during selective breeding conducted over several decades. METHODS: To identify genes important in determining muscle growth and feed efficiency in broilers, RNA sequencing (RNAseq) was conducted with breast muscle in modern pedigree male (PeM) broilers (n = 6 per group), and with an unselected foundation broiler line (Barred Plymouth Rock; BPR)...
January 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28086760/education-of-pediatric-subspecialty-fellows-in-transport-medicine-a-national-survey
#18
Geoffrey E Mickells, Denise M Goodman, Ranna A Rozenfeld
BACKGROUND: The transport of critically ill patients to children's hospitals is essential to current practice. The AAP Section on Transport Medicine has raised concerns about future leadership in the field as trainees receive less exposure to transport medicine. This study identifies the priorities of pediatric subspecialty fellows, fellowship directors and nursing directors in transport medicine education. METHODS: Internet based surveys were distributed to fellows, fellowship directors and nursing directors of transport teams affiliated with ACGME-approved fellowships in Neonatal-Perinatal Medicine (NPM), Pediatric Critical Care Medicine (PCCM), and Pediatric Emergency Medicine (PEM)...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28075559/one-component-supramolecular-filament-hydrogels-as-theranostic-label-free-magnetic-resonance-imaging-agents
#19
Lye Lin Lock, Yuguo Li, Xinpei Mao, Hanwei Chen, Verena Staedtke, Renyuan Bai, Wang Ma, Ran Lin, Yi Li, Guanshu Liu, Honggang Cui
Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in the clinic; however, safety concerns associated with their toxicities in the free ionic form have promoted the development of new generations of metal-free contrast agents. Here we report a supramolecular strategy to convert an FDA-approved anticancer drug, Pemetrexed (Pem), to a molecular hydrogelator with inherent chemical exchange saturation transfer (CEST) MRI signals. The rationally designed drug-peptide conjugate can spontaneously associate into filamentous assemblies under physiological conditions and consequently form theranostic supramolecular hydrogels for injectable delivery...
January 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28072617/evaluation-of-the-response-to-breast-cancer-neoadjuvant-chemotherapy-using-18f-fdg-positron-emission-mammography-compared-with-whole-body-18f-fdg-pet-a-prospective-observational-study
#20
Mutsumi Noritake, Kazutaka Narui, Tomohiro Kaneta, Sadatoshi Sugae, Kentaro Sakamaki, Tomio Inoue, Takashi Ishikawa
PURPOSE: The aim of this study was to assess therapeutic response to breast cancer neoadjuvant chemotherapy (NAC) by F-FDG positron emission mammography (PEM) compared with that to whole-body F-FDG PET (WBPET). METHODS: Twenty patients underwent WBPET and PEM 3 times: the first time was before NAC, the second time was after 2 courses of NAC, and the third time was after all courses of NAC. A pathological complete response (pCR) was defined as no evidence of residual invasive cancer with or without ductal carcinoma in situ...
March 2017: Clinical Nuclear Medicine
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