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https://www.readbyqxmd.com/read/29218614/18f-fluorodeoxyglucose-specimen-positron-emission-mammography-delineates-tumour-extension-in-breast-conserving-surgery-preliminary-results
#1
Gou Watanabe, M Itoh, X Duan, H Watabe, N Mori, H Tada, A Suzuki, M Miyashita, N Ohuchi, T Ishida
OBJECTIVES: We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (18F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff. METHODS: Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remaining 18F-FDG accumulation were scanned by high-resolution PEM...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29215964/real-world-fuel-use-and-gaseous-emission-rates-for-flex-fuel-vehicles-operated-on-e85-versus-gasoline
#2
Maryam Delavarrafiee, H Christopher Frey
Flex Fuel Vehicles (FFVs) typically operate on gasoline or E85, an 85%/15% volume blend of ethanol and gasoline, E85. Differences in FFV fuel use and tailpipe emission rates are quantified for E85 versus gasoline based on real-world measurements of five FFVs with a portable emissions measurement system (PEMS), supplemented chassis dynamometer data and estimates from the MOtor Vehicle Emission Simulator (MOVES) model. Because of inter-vehicle variability, an individual FFV may have higher nitrogen oxides (NOx) or carbon monoxide (CO) emission rates on E85 versus gasoline, even though average rates are lower...
December 7, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29215674/bioinspired-dynamic-microcapsules
#3
N F D AlDala'een, W N K W Mohamad, N Alias, A M Ali, J Shaikh Mohammed
There is an increasing interest in bioinspired dynamic materials. Abundant illustrations of protein domains exist in nature, with remarkable ligand binding characteristics and structures that undergo conformational changes. For example, calmodulin (CaM) can have three conformational states, which are the unstructured Apo-state, Ca2+-bound ligand-exposed binding state, and compact ligand-bound state. CaM's mechanical response to biological cues is highly suitable for engineering dynamic materials. The distance between CaM globular terminals in the Ca2+-bound state is 5 nm and in the ligand-bound state is 1...
December 7, 2017: Soft Matter
https://www.readbyqxmd.com/read/29190855/efficacy-of-lophira-alata-leaf-extract-and-its-combination-with-artesunate-in-mice-prior-exposed-to-plasmodium-berghei
#4
Mofolusho O Falade, Favour Komoni, Roseangela I Nwuba
Enhanced antimalarial activity of plant extracts used for treatment of malaria in endemic areas is attributed to partial immunity gained by prior infection. This suggests synergy between immunity and extract activity in treatment. Testing this hypothesis, rodent malaria was used to determine efficacy of Lophira alata leaf extracts in treating malaria in prior infected mice. One round of P. berghei infection and Pyrimethamine drug-cure was used to establish partial immunity in mice. Previously Exposed Mice (PEM) and Previously Unexposed Mice (PUM) mice challenged with P...
November 30, 2017: Drug Research
https://www.readbyqxmd.com/read/29186703/real-world-co2-and-nox-emissions-from-149-euro-5-and-6-diesel-gasoline-and-hybrid-passenger-cars
#5
Rosalind O'Driscoll, Marc E J Stettler, Nick Molden, Tim Oxley, Helen M ApSimon
In this study CO2 and NOx emissions from 149 Euro 5 and 6 diesel, gasoline and hybrid passenger cars were compared using a Portable Emissions Measurement System (PEMS). The models sampled accounted for 56% of all passenger cars sold in Europe in 2016. We found gasoline vehicles had CO2 emissions 13-66% higher than diesel. During urban driving, the average CO2 emission factor was 210.5 (sd. 47) gkm-1 for gasoline and 170.2 (sd. 34) gkm-1 for diesel. Half the gasoline vehicles tested were Gasoline Direct Injection (GDI)...
November 26, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29186089/correlation-between-methylenetetrahydrofolate-reductase-mthfr-c677t-polymorphisms-and-pemetrexed-chemotherapy-efficacy-toxicity-in-non-squamous-non-small-cell-lung-cancer
#6
Gaochen Lan, Lin Lin, Xiong Chen, Libin Chen, Xi Chen
BACKGROUND In the present study, we aimed to retrospectively analyze the correlation between toxicity of pemetrexed (PEM) chemotherapy and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in patients with advanced non-squamous non-small cell lung cancer (non-sq NSCLC). MATERIAL AND METHODS We used polymerase chain reaction, gene scanning, and restriction fragment length polymorphism to analyze MTHFR C677T in 51 patients with advanced non-sq NSCLC. The patients received chemotherapies with single-agent PEM (monotherapy group) or with PEM combined with cisplatin (joint group)...
November 29, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29171009/bevacizumab-in-combination-with-different-platinum-based-doublets-in-the-first-line-treatment-for-advanced-nonsquamous-non-small-cell-lung-cancer-a-network-meta-analysis
#7
Shen Zhao, Fangfang Gao, Yaxiong Zhang, Zhonghan Zhang, Li Zhang
Platinum-based doublet chemotherapy with or without bevacizumab is the standard treatment for untreated advanced nonsquamous non-small-cell lung cancer (NS-NSCLC). However, adding bevacizumab to chemotherapies other than paclitaxel-carboplatin is, though widely applied clinically, largely unjustified due to the lack of head-to-head data. We performed a Bayesian network meta-analysis (NMA) to address this important issue. Data of 8548 patients from 18 randomized controlled trials (RCTs) receiving six treatments including taxane-platinum (Taxane-Pt), gemcitabine-platinum (Gem-Pt), pemetrexed-platinum (Pem-Pt), taxane-platinum + bevacizumab (Taxane-Pt+B), gemcitabine-platinum + bevacizumab (Gem-Pt+B) and pemetrexed-platinum + bevacizumab (Pem-Pt+B) were incorporated into the analyses...
November 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29166773/a-simple-polymer-electrolyte-membrane-system-for-enrichment-of-low-level-tritium-3-h-in-environmental-water-samples
#8
Leonard I Wassenaar, Liang-Feng Han, Thomas Schiefer, Gustav Kainz, Luis Araguas-Araguas, Pradeep K Aggarwal
Tritium ((3)H) is an essential tracer of the Earth's water cycle; yet widespread adoption of tritium in hydrologic studies remains a challenge because of analytical barriers to quantification and detection of (3)H by electrolytic pre-concentration. Here, we propose a simple tritium electrolytic enrichment system based on the use of solid polymer electrolyte membranes (PEMs) that can be used to enrich (3)H in 250-3000 mL environmental water samples to a 10-mL final volume. The IAEA PEM-(3)H system reported here can produce high enrichment factors (>70-fold) and, importantly, removes some of the deterrents to conventional (3)H enrichments methods, including the use of toxic electrolysis and neutralization chemicals, spike standards, a complex electrolysis apparatus that requires extensive cooling and temperature controls, and improves precision by eliminating the need for tracking recovery gravimetrics...
November 22, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/29155388/polyelectrolyte-multilayers-for-bio-applications-recent-advancements
#9
REVIEW
Suman Pahal, Ruchi Gakhar, Ashok M Raichur, Manoj M Varma
The synergistic relationship between structure and the bulk properties of polyelectrolyte multilayer (PEM) films has generated tremendous interest in their application for loading and release of bioactive species. Layer-by-layer assembly is the simplest, cost effective process for fabrication of such PEMs films, leading to one of the most widely accepted platforms for incorporating biological molecules with nanometre precision. The bulk reservoir properties of PEM films render them a potential candidate for applications such as biosensing, drug delivery and tissue engineering...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29151111/readability-assessment-of-patient-education-material-published-by-german-speaking-associations-of-urology
#10
Patrick Betschart, Valentin Zumstein, Omar Hasan Ali, Hans-Peter Schmid, Dominik Abt
OBJECTIVE: To assess the readability and comprehensibility of web-based German-language patient education material (PEM) issued by urological associations. MATERIALS AND METHODS: German PEM available in June 2017 was obtained from the European Association of Urology (EAU), German (DGU), Swiss (SGU) and Austrian (ÖGU) Association of Urology websites. Each educational text was analyzed separately using 4 well-established readability assessment tools: the Amstad Test (AT), G-SMOG (SMOG), Wiener Sachtextformel (WS) and the Lesbarkeitsindex (LIX)...
November 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29148782/effect-of-side-chain-branching-on-enhancement-of-ionic-conductivity-and-capacity-retention-of-copolymer-electrolyte-membrane
#11
Guopeng Fu, Thein Kyu
Low current drain driven by the low ionic conductivity of solid polymer electrolyte is one of the major obstacles of solid state battery. In an effort to improve the ionic conductivity, polyethylene glycol diacrylate (PEGDA) and monofunctional polyethylene glycol methyl ether acrylate (PEGMEA) were copolymerized via photopolymerization to afford PEGDA network with dangling PEGMEA side chains. By attaching PEGMEA side branches to the PEGDA network backbone, the glass transition temperature (Tg) was found to decrease, which may be controlled by varying relative amounts of PEGMEA and PEGDA...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29143830/gramicidin-ion-channels-in-a-lipid-bilayer-supported-on-polyelectrolyte-multilayer-films-an-electrochemical-impedance-study
#12
Eleftheria Diamanti, Eduart Gutiérrez-Pineda, Nikolaos Politakos, Patrizia Andreozzi, María José Rodriguez-Presa, Wolfgang Knoll, Omar Azzaroni, Claudio A Gervasi, Sergio E Moya
Supported membranes on polymer cushions are of fundamental interest as models for cell membranes. The use of polyelectrolyte multilayers (PEMs) assembled by the layer by layer (LbL) technique as supports for a bilayer allows for easy integration of the lipid bilayer on surfaces and devices and for nanoscale tunable spacing of the lipid bilayer. Controlling ionic permeability in lipid bilayers supported on PEMs triggers potential applications in sensing and as models for transport phenomena in cell membranes...
November 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/29140718/pem-fitter-a-coarse-grained-method-to-validate-protein-candidate-models
#13
Kamal Al Nasr, Christopher Jones, Feras Yousef, Ruba Jebril
The volumetric images produced by Cryo-Electron Microscopy (cryo-EM) technique are used to model macromolecular assemblies and machines. De novo protein modeling uses these images to computationally model the structure of the molecules. Many candidate conformations are usually generated during the intermediate step. Conventionally, each of these candidates is evaluated by time-consuming approaches such as potential energy. We introduce an initial version of a geometrical screening method that uses the skeleton of the cryo-EM images to evaluate candidate structures...
November 15, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29139224/a-polyelectrolyte-multilayer-platform-for-investigating-growth-factor-delivery-modes-in-human-liver-cultures
#14
Christine Lin, Raimundo Romero, Lioudmila V Sorokina, Kimberly R Ballinger, Laura W Place, Matt J Kipper, Salman R Khetani
Polyelectrolyte multilayers (PEMs) of chitosan and heparin are useful for mimicking growth factor (GF) binding to extracellular matrix (ECM) as in vivo. Here, we developed a PEM platform for delivering bound/adsorbed GFs to monocultures of primary human hepatocytes (PHHs) and PHH/non-parenchymal cell (NPC) co-cultures, which are useful for drug development and regenerative medicine. The effects of ECM protein coating (collagen I, fibronectin, and Matrigel®) and terminal PEM layer on PHH attachment/functions were determined...
November 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29137057/readability-of-internet-sourced-patient-education-material-related-to-labour-analgesia
#15
Nilay Boztas, Dilek Omur, Sule Ozbılgın, Gözde Altuntas, Ersan Piskin, Sevda Ozkardesler, Volkan Hanci
We evaluated the readability of Internet-sourced patient education materials (PEMs) related to "labour analgesia." In addition to assessing the readability of websites, we aimed to compare commercial, personal, and academic websites.We used the most popular search engine (http://www.google.com) in our study. The first 100 websites in English that resulted from a search for the key words "labour analgesia" were scanned. Websites that were not in English, graphs, pictures, videos, tables, figures and list formats in the text, all punctuation, the number of words in the text is less than 100 words, feedback forms not related to education, (Uniform Resource Locator) URL websites, author information, references, legal disclaimers, and addresses and telephone numbers were excluded...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132084/integrated-and-ecosystemic-approaches-for-bridging-the-gap-between-environmental-management-and-port-management
#16
Javier García-Onetti, Marinez E G Scherer, Juan Manuel Barragán
The rapid exploitation of coastal and marine ecosystemic capital is on course to reach a critical point. The difficulty of implementing Integrated and ecosystem based management models, taking into the account the great complexity of the marine socio-ecological systems, has resulted in a significant gap between theory and practice. The majority of authors emphasize difficulties in engaging and convincing private stakeholders and a number of economic sectors involved in these processes. This reticence is traditionally more pronounced in the port sector, despite their important role in the transformation of coastal and marine areas...
November 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29128586/contraception-pregnancy-and-peripartum-experiences-among-women-with-epilepsy-in-bhutan
#17
Sheliza Halani, Lhab Tshering, Esther Bui, Sarah J Clark, Sara J Grundy, Tandin Pem, Sonam Lhamo, Ugyen Dema, Damber K Nirola, Chencho Dorji, Farrah J Mateen
INTRODUCTION: Reports on the reproductive health of women with epilepsy (WWE) in low- and middle-income countries (LMICs) are limited. Bhutan is a lower income country with a high estimated prevalence of epilepsy and no out-of-pocket payment requirements for health visits or medications. METHODS: We developed a 10-category survey to interview WWE ages 20-59 years in the Kingdom of Bhutan to understand their contraceptive use and peripartum experiences. WWE were recruited from 2016-2017 from an existing epilepsy cohort and their reproductive health data were merged with epilepsy and socioeconomic data obtained from initial clinical evaluations performed between 2014 and 2016...
December 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29115339/electro-oxidation-of-a-cobalt-based-steel-in-lioh-a-non-noble-metal-based-electro-catalyst-suitable-for-durable-water-splitting-in-an-acidic-milieu
#18
Helmut Schäfer, Karsten Küpper, Klaus Müller-Buschbaum, Diemo Daum, Martin Steinhart, Joachim Wollschläger, Ulrich Krupp, Mercedes Schmidt, Weijia Han, Johannes Stangl
The use of proton exchange membrane (PEM) electrolyzers is the method of choice for the conversion of solar energy when frequently occurring changes of the current load are an issue. However, this technique requires electrolytes with low pH. All oxygen evolving electrodes working durably and actively in acids contain IrOx. Due to their scarcity and high acquisition costs, noble elements like Pt, Ru and Ir need to be replaced by earth abundant elements. We have evaluated a cobalt containing steel for use as an oxygen-forming electrode in H2SO4...
November 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/29111613/management-of-shiga-toxin-producing-escherichia-coli-infected-children-a-multi-national-multi-specialty-survey
#19
Stephen B Freedman, Silviu Grisaru, Jianling Xie, Susan Samuel, Andrew Dixon, Amy C Plint, David Schnadower
AIM: Research has highlighted the potential role that hydration status may play in predicting outcomes in Shiga toxin-producing Escherichia coli (STEC)-infected children. Because little is known about the management of STEC-infected children in the pre-haemolytic uremic syndrome phase, we compared paediatric emergency medicine and nephrologist-stated management approaches to STEC-infected children. METHODS: Members of the Pediatric Emergency Research Canada (PERC; n = 228), the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC; n = 221) and the Canadian Association of Pediatric Nephrologists (CAPN; n = 66) were surveyed...
November 7, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29104541/identification-and-differential-abundance-of-mitochondrial-genome-encoding-small-rnas-mitosrna-in-breast-muscles-of-modern-broilers-and-unselected-chicken-breed
#20
Walter G Bottje, Bhuwan Khatri, Stephanie A Shouse, Dongwon Seo, Barbara Mallmann, Sara K Orlowski, Jeonghoon Pan, Seongbae Kong, Casey M Owens, Nicholas B Anthony, Jae K Kim, Byungwhi C Kong
Background: Although small non-coding RNAs are mostly encoded by the nuclear genome, thousands of small non-coding RNAs encoded by the mitochondrial genome, termed as mitosRNAs were recently reported in human, mouse and trout. In this study, we first identified chicken mitosRNAs in breast muscle using small RNA sequencing method and the differential abundance was analyzed between modern pedigree male (PeM) broilers (characterized by rapid growth and large muscle mass) and the foundational Barred Plymouth Rock (BPR) chickens (characterized by slow growth and small muscle mass)...
2017: Frontiers in Physiology
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