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https://www.readbyqxmd.com/read/29235882/early-warning-systems-for-the-management-of-chronic-heart-failure-a-systematic-literature-review-of-cost-effectiveness-models
#1
Fernando Albuquerque de Almeida, Maiwenn Al, Ron Koymans, Kadir Caliskan, Ankie Kerstens, Johan L Severens
Introduction Describing the general and methodological characteristics of decision-analytical models used in the economic evaluation of early warning systems for the management of chronic heart failure patients and performing a quality assessment of their methodological characteristics is expected to provide concise and useful insight to inform the future development of decision-analytical models in the field of heart failure management. Areas covered The literature on decision-analytical models for the economic evaluation of early warning systems for the management of chronic heart failure patients was systematically reviewed...
December 13, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29224315/-identification-of-a-novel-anki-gene-mutation-in-hereditary-spherocytosis
#2
Y D Gao, G Li, Y T Bao, Y R Song, B B Zhang, Y M Jiang, L Gao, J Wang, G Y Chen
No abstract text is available yet for this article.
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29157121/signed-family-physician-reminder-letters-to-women-overdue-for-screening-mammography-a-randomized-clinical-trial
#3
Elisa K Chan, Christine Wilson, Scott Tyldesley, Ivo A Olivotto, Anky Lai, Janette Sam, Ritinder Harry, Alan Nichol
Objective To determine whether signed family physician reminder letters to women overdue for screening mammography prompts rescreening. Methods A randomized double-blind trial conducted in 2013 among women aged 51-73 and overdue for screening by 6-24 months. The study was carried out by the publicly funded British Columbia Cancer Agency Screening Mammography Program, which routinely sends standard reminder postcards to women who are due for mammography. Participating family physicians signed letters for the overdue women in their practices...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28950757/better-platelet-function-less-fibrinolysis-and-less-hemolysis-in-re-transfused-residual-pump-blood-with-the-ringer-s-chase-technique-a-randomized-pilot-study
#4
Anki Olsson, Joakim Alfredsson, Sofia Ramström, Rolf Svedjeholm, Dermot Kenny, Eric Håkansson, Johan Sanmartin Berglund, Sören Berg
INTRODUCTION: Residual pump blood from the cardiopulmonary bypass (CPB) circuit is often collected into an infusion bag (IB) and re-transfused. An alternative is to chase the residual blood into the circulation through the arterial cannula with Ringer's acetate. Our aim was to assess possible differences in hemostatic blood quality between these two techniques. METHODS: Forty adult patients undergoing elective coronary artery bypass graft surgery with CPB were randomized to receive the residual pump blood by either an IB or through the Ringer's chase (RC) technique...
September 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28879152/national-laboratory-policies-and-plans-in-sub-saharan-african-countries-gaps-and-opportunities
#5
Pascale Ondoa, Ankie van der Broek, Christel Jansen, Hilde de Bruijn, Constance Schultsz
BACKGROUND: The 2008 Maputo Declaration calls for the development of dedicated national laboratory policies and strategic plans supporting the enhancement of laboratory services in response to the long-lasting relegation of medical laboratory systems in sub-Saharan Africa. OBJECTIVES: This study describes the extent to which laboratories are addressed in the national health policies and plans created directly following the 2008 momentum for laboratory strengthening...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28859141/asporin-deficient-mice-have-tougher-skin-and-altered-skin-glycosaminoglycan-content-and-structure
#6
Marco Maccarana, René B Svensson, Anki Knutsson, Antonis Giannopoulos, Mea Pelkonen, MaryAnn Weis, David Eyre, Matthew Warman, Sebastian Kalamajski
The main structural component of connective tissues is fibrillar, cross-linked collagen whose fibrillogenesis can be modulated by Small Leucine-Rich Proteins/Proteoglycans (SLRPs). Not all SLRPs' effects on collagen and extracellular matrix in vivo have been elucidated; one of the less investigated SLRPs is asporin. Here we describe the successful generation of an Aspn-/- mouse model and the investigation of the Aspn-/- skin phenotype. Functionally, Aspn-/- mice had an increased skin mechanical toughness, although there were no structural changes present on histology or immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28768613/medicine-goes-female-protocol-for-improving-career-options-of-females-and-working-conditions-for-researching-physicians-in-clinical-medical-research-by-organizational-transformation-and-participatory-design
#7
Joachim Hasebrook, Klaus Hahnenkamp, Wolfgang F F A Buhre, Dianne de Korte-de Boer, Ankie E W Hamaekers, Bibiana Metelmann, Camila Metelmann, Marina Bortul, Silvia Palmisano, Jannicke Mellin-Olsen, Andrius Macas, Janusz Andres, Anna Prokop-Dorner, Tomáš Vymazal, Juergen Hinkelmann, Sibyll Rodde, Bettina Pfleiderer
BACKGROUND: All European countries need to increase the number of health professionals in the near future. Most efforts have not brought the expected results so far. The current notion is that this is mainly related to the fact that female physicians will clearly outnumber their male colleagues within a few years in nearly all European countries. Still, women are underrepresented in leadership and research positions throughout Europe. OBJECTIVES: The MedGoFem project addresses multiple perspectives with the participation of multiple stakeholders...
August 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28768281/%C3%AE-sarcoglycan-deficiency-reduces-atherosclerotic-plaque-development-in-apoe-null-mice
#8
Vignesh Murugesan, Eva Degerman, Ann-Kristin Holmen-Pålbrink, Pontus Duner, Anki Knutsson, Anna Hultgårdh-Nilsson, Uwe Rauch
BACKGROUND: Smooth muscle cells are important for atherosclerotic plaque stability. Their proper ability to communicate with the extracellular matrix is crucial for maintaining the correct tissue integrity. In this study, we have investigated the role of β-sarcoglycan within the matrix-binding dystrophin-glycoprotein complex in the development of atherosclerosis. RESULTS: Atherosclerotic plaque development was significantly reduced in ApoE-deficient mice lacking β-sarcoglycan, and their plaques contained an increase in differentiated smooth muscle cells...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28752089/the-use-of-operational-excellence-principles-in-a-university-hospital
#9
Eric R Edelman, Ankie E W Hamaekers, Wolfgang F Buhre, Godefridus G van Merode
The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+) has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28729306/hospital-variation-in-allogeneic-transfusion-and-extended-length-of-stay-in-primary-elective-hip-and-knee-arthroplasty-a-cross-sectional-study
#10
Veronique M A Voorn, Perla J Marang-van de Mheen, Anja van der Hout, Cynthia So-Osman, M Elske van den Akker-van Marle, Ankie W M M Koopman-van Gemert, Albert Dahan, Thea P M Vliet Vlieland, Rob G H H Nelissen, Leti van Bodegom-Vos
OBJECTIVES: Outcomes in total hip and knee arthroplasty (THA and TKA), such as allogeneic transfusions or extended length of stay (LoS), can be used to compare the performance of hospitals. However, there is much variation in these outcomes. This study aims to rank hospitals and to assess hospital differences of two outcomes in THA and TKA: allogeneic transfusions and extended LoS, and to additionally identify factors associated with these differences. DESIGN: Cross-sectional medical record review study...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28674693/improving-the-prediction-of-total-surgical-procedure-time-using-linear-regression-modeling
#11
Eric R Edelman, Sander M J van Kuijk, Ankie E W Hamaekers, Marcel J M de Korte, Godefridus G van Merode, Wolfgang F F A Buhre
For efficient utilization of operating rooms (ORs), accurate schedules of assigned block time and sequences of patient cases need to be made. The quality of these planning tools is dependent on the accurate prediction of total procedure time (TPT) per case. In this paper, we attempt to improve the accuracy of TPT predictions by using linear regression models based on estimated surgeon-controlled time (eSCT) and other variables relevant to TPT. We extracted data from a Dutch benchmarking database of all surgeries performed in six academic hospitals in The Netherlands from 2012 till 2016...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28602609/satellite-rats-are-redundant-in-embryo-fetal-development-studies
#12
Manon Beekhuijzen, Yaomi de Lange, Ankie Lambregts, Birgit Peter, Mira Wenker, Harry Emmen
Routinely in many laboratories, satellite rats are added to embryo-fetal development (EFD) studies for pharmaceuticals to assess toxicokinetic (TK) properties, because it is assumed that collection of multiple blood samples with relatively large volumes might affect the study outcome. With recent refinement of blood sampling techniques, this belief requires reevaluation. The current work showed successful implementation of jugular vein blood sampling in an EFD rat study without satellite animals, thereby reducing the number of rats in standard EFD studies for pharmaceuticals by 20%...
June 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28558843/the-effectiveness-of-a-de-implementation-strategy-to-reduce-low-value-blood-management-techniques-in-primary-hip-and-knee-arthroplasty-a-pragmatic-cluster-randomized-controlled-trial
#13
Veronique M A Voorn, Perla J Marang-van de Mheen, Anja van der Hout, Stefanie N Hofstede, Cynthia So-Osman, M Elske van den Akker-van Marle, Ad A Kaptein, Theo Stijnen, Ankie W M M Koopman-van Gemert, Albert Dahan, Thea P M M Vliet Vlieland, Rob G H H Nelissen, Leti van Bodegom-Vos
BACKGROUND: Perioperative autologous blood salvage and preoperative erythropoietin are not (cost) effective to reduce allogeneic transfusion in primary hip and knee arthroplasty, but are still used. This study aimed to evaluate the effectiveness of a theoretically informed multifaceted strategy to de-implement these low-value blood management techniques. METHODS: Twenty-one Dutch hospitals participated in this pragmatic cluster-randomized trial. At baseline, data were gathered for 924 patients from 10 intervention and 1040 patients from 11 control hospitals undergoing hip or knee arthroplasty...
May 30, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28550192/comparison-of-risk-prediction-scores-for-venous-thromboembolism-in-cancer-patients-a-prospective-cohort-study
#14
Nick van Es, Marcello Di Nisio, Gabriela Cesarman, Ankie Kleinjan, Hans-Martin Otten, Isabelle Mahé, Ineke T Wilts, Desirée C Twint, Ettore Porreca, Oscar Arrieta, Alain Stépanian, Kirsten Smit, Michele De Tursi, Suzanne M Bleker, Patrick M Bossuyt, Rienk Nieuwland, Pieter W Kamphuisen, Harry R Büller
In ambulatory patients with solid cancer, routine thromboprophylaxis to prevent venous thromboembolism is not recommended. Several risk prediction scores to identify cancer patients at high risk of venous thromboembolism have been proposed, but their clinical usefulness remains a matter of debate. We evaluated and directly compared the performance of the Khorana, Vienna, PROTECHT, and CONKO scores in a multinational, prospective cohort study. Patients with advanced cancer were eligible if they were due to undergo chemotherapy or had started chemotherapy in the previous three months...
September 2017: Haematologica
https://www.readbyqxmd.com/read/28506574/the-degree-of-integration-of-non-dispensing-pharmacists-in-primary-care-practice-and-the-impact-on-health-outcomes-a-systematic-review
#15
REVIEW
Ankie C M Hazen, Antoinette A de Bont, Lia Boelman, Dorien L M Zwart, Johan J de Gier, Niek J de Wit, Marcel L Bouvy
BACKGROUND: A non-dispensing pharmacist conducts clinical pharmacy services aimed at optimizing patients individual pharmacotherapy. Embedding a non-dispensing pharmacist in primary care practice enables collaboration, probably enhancing patient care. The degree of integration of non-dispensing pharmacists into multidisciplinary health care teams varies strongly between settings. The degree of integration may be a determinant for its success. OBJECTIVES: This study investigates how the degree of integration of a non-dispensing pharmacist impacts medication related health outcomes in primary care...
April 22, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28410335/experiences-of-oncology-and-palliative-care-nurses-when-supporting-parents-who-have-cancer-and-dependent-children
#16
Anne Arber, Anki Odelius
BACKGROUND: It is important not to ignore the impact of parental cancer on children, and this is where oncology and palliative care nurses can play a key role, providing support to parents as a regular aspect of oncological nursing care. OBJECTIVES: This study explored the experience, needs, and confidence of nurses working in acute cancer services when supporting parents with cancer who have dependent children. METHODS: Two focus group interviews were conducted with oncology and palliative care nurses in 1 acute hospital trust in the south of England...
April 13, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28188722/prevalence-of-hypokalemia-before-and-after-bowel-preparation-for-colonoscopy-in-high-risk-patients
#17
Ankie Reumkens, Ad A Masclee, Bjorn Winkens, Cees T van Deursen, Silvia Sanduleanu, Christine M Bakker
BACKGROUND AND AIMS: Bowel preparation for colonoscopy should not cause significant shifts in systemic electrolyte concentrations. We recently encountered 2 cases of severe postcolonoscopy hypokalemia with fatal consequences, prompting us to conduct a study to explore the magnitude of and risk factors for hypokalemia associated with bowel preparation. We paid specific attention to higher-risk subgroups, in particular, diuretic users, hospitalized patients, and patients estimated to be at high risk by the gastroenterologist...
October 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28154389/response-to-jacobo-dib-jr
#18
Ankie Reumkens, Silvia Sanduleanu
No abstract text is available yet for this article.
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28132615/implementing-and-assessing-the-value-of-nursing-preceptorship
#19
REVIEW
Anki Odelius, Michael Traynor, Sinead Mehigan, Mercy Wasike, Chris Caldwell
Preceptorship was first promoted as part of the Project 2000 reforms, and evidence suggests it remains valuable to newly qualified nurses. Although there is a lack of research of its effect on patient care, what research there is highlights various positive aspects of preceptorship programmes for newly qualified nurses, preceptors, and organisations. This article summarises the results of a scoping review of the literature, published since 2009, on preceptorship. It also describes a preceptorship initiative in London led by Health Education England...
January 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28125016/testing-human-skin-and-respiratory-sensitizers-what-is-good-enough
#20
REVIEW
Anki Malmborg, Carl A K Borrebaeck
Alternative methods for accurate in vitro assessment of skin and respiratory sensitizers are urgently needed. Sensitization is a complex biological process that cannot be evaluated accurately using single events or biomarkers, since the information content is too restricted in these measurements. On the contrary, if the tremendous information content harbored in DNA/mRNA could be mined, most complex biological processes could be elucidated. Genomic technologies available today, including transcriptional profiling and next generation sequencing, have the power to decipher sensitization, when used in the right context...
January 24, 2017: International Journal of Molecular Sciences
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