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Nick van Es, Suzanne Bleker, Marcello Di Nisio, Ankie Kleinjan, Jan Beyer-Westendorf, Giuseppe Camporese, Anita Aggarwal, Peter Verhamme, Marc Righini, Harry R Büller, Patrick M Bossuyt
BACKGROUND: Among patients with clinically suspected upper extremity deep vein thrombosis (UEDVT), a clinical decision rule based on the Constans score combined with D-dimer testing can safely rule out the diagnosis without imaging in approximately one-fifth of patients. OBJECTIVES: To evaluate the performance of the original Constans score, an extended Constans score, and an age-adjusted D-dimer positivity threshold. METHODS: Data of 406 patients with suspected UEDVT previously enrolled in a multinational diagnostic management study were used...
October 12, 2016: Journal of Thrombosis and Haemostasis: JTH
Ankie Sterk, Heleen de Man, Jack F Schijven, Ton de Nijs, Ana Maria de Roda Husman
Climate change is expected to influence infection risks while bathing downstream of sewage emissions from combined sewage overflows (CSOs) or waste water treatment plants (WWTPs) due to changes in pathogen influx, rising temperatures and changing flow rates of the receiving waters. In this study, climate change impacts on the surface water concentrations of Campylobacter, Cryptosporidium and norovirus originating from sewage were modelled. Quantitative microbial risk assessment (QMRA) was used to assess changes in risks of infection...
November 15, 2016: Water Research
Cees Bm Oudejans, Ankie Poutsma, Omar J Michel, Hari K Thulluru, Joyce Mulders, Henri J van de Vrugt, Erik A Sistermans, Marie van Dijk
The familial forms of early onset pre-eclampsia and related syndromes (HELLP) present with hypertension and proteinuria in the mother and growth restriction of the fetus. Genetically, these clinically similar entities are caused by different founder-dependent, placentally-expressed paralogous genes. All susceptibility genes (STOX1, lincHELLP, INO80B) identified so far are master control genes that regulate an essential trophoblast differentiation pathway, but act at different entry points. Many genes remain to be identified...
2016: Scientific Reports
Ankie C M Hazen, Aletta W van der Wal, Vivianne M Sloeserwij, Dorien L M Zwart, Johan J de Gier, Niek J de Wit, Anne J Leendertse, Marcel L Bouvy, Antoinette A de Bont
UNLABELLED: Background Controversy about the introduction of a non-dispensing pharmacist in primary care practice hampers implementation. Objective The aim of this study is to systematically map the debate on this new role for pharmacists amongst all stakeholders to uncover and understand the controversy and consensus. SETTING: Primary health care in the Netherlands. Method Q methodology. 163 participants rank-ordered statements on issues concerning the integration of a non-dispensing pharmacist in primary care practice...
October 2016: International Journal of Clinical Pharmacy
Ashim Malakar, Manishekhar Kumar, Anki Reddy, Himadree T Biswal, Biman B Mandal, G Krishnamoorthy
In this study, the aggregation induced emission enhancement (AIEE) of 2-(2'-hydroxyphenyl)benzimidazole (HPBI) is reported. To investigate the AIEE process of HPBI, absorption/fluorescence spectroscopy, fluorescence imaging and field emission scanning electron microscopy were employed. A comparative study with 2-phenylbenzimidazole (PBI) divulges the significance of the hydroxyl group in the AIEE process. Further, molecular dynamics simulations have been carried out with explicit solvent molecules to follow the aggregation process of HPBI with time...
July 6, 2016: Photochemical & Photobiological Sciences
Ankie Reumkens, Eveline J A Rondagh, C Minke Bakker, Bjorn Winkens, Ad A M Masclee, Silvia Sanduleanu
OBJECTIVES: Many studies around the world addressed the post-colonoscopy complications, but their pooled prevalence and time trends are unknown. We performed a systematic review and meta-analysis of population-based studies to examine the pooled prevalence of post-colonoscopy complications ("perforation", "bleeding", and "mortality"), stratified by colonoscopy indication. Temporal variability in the complication rate was assessed. METHODS: We queried Pubmed, Embase, and the Cochrane library for population-based studies examining post-colonoscopy complications (within 30 days), performed from 2001 to 2015 and published by 1 December 2015...
August 2016: American Journal of Gastroenterology
Anki Nordmarker, Fredrik Hjärthag, Renée Perrin-Wallqvist, Trevor Archer
A total of 360 upper secondary school students in Sweden were divided into three grouping variables: gender (male, female), vandalism (involved, not involved), and scrawl-graffiti (involved, not involved). Relevant to the discussion of whether or not scrawl-graffiti may be construed as vandalism or art, the aim of the study was to explore whether or not personality factors known to be linked to vandalism in general (such as impulsivity, affectivity, emotional disability, and optimism) are related also to involvement in scrawl-graffiti, and, furthermore, how the gender factor relates to vandalism and scrawl-graffiti, respectively...
September 2016: PsyCh Journal
Anki Knutsson, Sabrina Hsiung, Selvi Celik, Sara Rattik, Ingrid Yao Mattisson, Maria Wigren, Howard I Scher, Jan Nilsson, Anna Hultgårdh-Nilsson
Androgen-deprivation therapy (ADT) for prostate cancer has been associated with increased risk for development of cardiovascular events and recent pooled analyses of randomized intervention trials suggest that this primarily is the case for patients with pre-existing cardiovascular disease treated with gonadotropin-releasing hormone receptor (GnRH-R) agonists. In the present study we investigated the effects of the GnRH-R agonist leuprolide and the GnRH-R antagonist degarelix on established atherosclerotic plaques in ApoE(-/-) mice...
2016: Scientific Reports
Suzanne M Bleker, Nick van Es, Luuk van Gils, Joost G Daams, Ankie Kleinjan, Harry R Büller, Marcello Di Nisio
BACKGROUND: The incidence of upper extremity deep vein thrombosis (UEDVT) is increasing. Information on the clinical course of UEDVT is scarce, especially in cancer patients. AIM: To summarize the clinical evidence regarding long-term clinical outcomes of UEDVT, in terms of recurrent venous thromboembolism (VTE), mortality, and anticoagulant-related bleeding, in patients with or without concomitant cancer. METHODS: A systematic search of the literature was conducted in MEDLINE, EMBASE and BIOSIS Previews...
April 2016: Thrombosis Research
Ankie Sterk, Jack Schijven, Ana Maria de Roda Husman, Ton de Nijs
Faeces originating from wildlife, domestic animals or manure-fertilized fields, is considered an important source of zoonotic pathogens to which people may be exposed by, for instance, bathing or drinking-water consumption. An increase in runoff, and associated wash-off of animal faeces from fields, is assumed to contribute to the increase of disease outbreaks during periods of high precipitation. Climate change is expected to increase winter precipitation and extreme precipitation events during summer, but has simultaneously also other effects such as temperature rise and changes in evapotranspiration...
May 15, 2016: Water Research
Cees Oudejans, Ankie Poutsma, Omar Michel, Joyce Mulders, Allerdien Visser, Marie van Dijk, Tessa Nauta, Anouk Bokslag, Walter Paulus, Andreas de Haas, Pieter Koolwijk, Christianne J M de Groot
BACKGROUND: The physiological demands of pregnancy on the maternal cardiovascular system can catapult women into a metabolic syndrome that predisposes to atherosclerosis in later life. We sought to identify the nature of the epigenomic changes associated with the increased cardiovascular disease (CVD) risk in adult women following pre-eclampsia. FINDINGS: We assessed the genome wide epigenetic profile by methyl-C sequencing of monozygotic parous twin sister pairs discordant for a severe variant of pre-eclampsia...
2016: PloS One
S M Bleker, N van Es, A Kleinjan, H R Büller, P W Kamphuisen, A Aggarwal, J Beyer-Westendorf, G Camporese, B Cosmi, T Gary, A Ghirarduzzi, K Kaasjager, T Lerede, P Marschang, K Meijer, H-M Otten, E Porreca, M Righini, P Verhamme, S van Wissen, M Di Nisio
UNLABELLED: Essentials Few data exist on outcome of upper extremity deep and superficial vein thrombosis (UEDVT and UESVT). We followed 102 and 55 patients with UEDVT or UESVT, respectively, for a median of 3.5 years. Risk of recurrent venous thromboembolism was low in both diseases, and the mortality high. Postthrombotic symptoms were infrequent and cancer patients had a higher risk of recurrent VTE. SUMMARY: Background There is scant information on the optimal management and clinical outcome of deep and superficial vein thrombosis of the upper extremity (UEDVT and UESVT)...
May 2016: Journal of Thrombosis and Haemostasis: JTH
Siu W Lam, Nienke M Nota, Agnes Jager, Monique M E M Bos, Joan van den Bosch, Ankie M T van der Velden, Johanneke E A Portielje, Aafke H Honkoop, Harm van Tinteren, Epie Boven
PURPOSE: We examined whether pretreatment levels of angiogenesis- or hypoxia-related proteins and their changes after one cycle of first-line bevacizumab-based therapy were associated with response, PFS, or OS in patients with metastatic breast cancer. EXPERIMENTAL DESIGN: We included 181 patients enrolled in the phase II ATX trial evaluating first-line paclitaxel and bevacizumab without or with capecitabine (NTR1348). Plasma samples were analyzed for VEGF-A, soluble VEGFR2 (sVEGFR2), angiopoietin 2 (ANG2), soluble TIE2 (sTIE2), IL6, IL8, and carbonic anhydrase 9 (CA9)...
April 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Nina Mishelmovich, Anne Arber, Anki Odelius
PURPOSE: The aim of the research was to explore specialist cancer and palliative care nurses experience of delivering significant news to patients with advanced cancer. METHOD: A qualitative phenomenological research study was conducted to capture nurses' experiences with the aim of understanding how cancer and palliative care clinical nurse specialists work towards disclosure of advanced and terminal cancer. Data were collected through semi-structured interviews with 10 clinical nurse specialists working in one acute NHS trust...
April 2016: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Henk Schonewille, Áine Honohan, Leo M G van der Watering, Francisca Hudig, Peter A Te Boekhorst, Ankie W M M Koopman-van Gemert, Anneke Brand
BACKGROUND: Most incidentally transfused patients receive only ABO-D-compatible transfusions and antibodies are formed in up to 8%. The effect of extended (c, C, E, K, Fy(a) , Jk(a) , and S antigens) matched (EM) and ABO-D-matched red blood cell (RBC) transfusions on the incidence of new clinically relevant RBC antibody formation after a first elective transfusion event in surgical patients was studied. STUDY DESIGN AND METHODS: A multicenter randomized trial was performed in nontransfused patients who were scheduled to experience a single elective transfusion event of maximal 4 RBC units...
February 2016: Transfusion
Annelie Shami, Anki Knutsson, Pontus Dunér, Uwe Rauch, Eva Bengtsson, Christoffer Tengryd, Vignesh Murugesan, Madeleine Durbeej, Isabel Gonçalves, Jan Nilsson, Anna Hultgårdh-Nilsson
Dystrophin of the dystrophin-glycoprotein complex connects the actin cytoskeleton to basement membranes and loss of dystrophin results in Duchenne muscular dystrophy. We have previously shown injury-induced neointima formation of the carotid artery in mice with the mdx mutation (causing dystrophin deficiency) to be increased. To investigate the role of dystrophin in intimal recruitment of smooth muscle cells (SMCs) that maintains plaque stability in atherosclerosis we applied a shear stress-modifying cast around the carotid artery of apolipoprotein E (ApoE)-null mice with and without the mdx mutation...
2015: Scientific Reports
Marie van Dijk, Allerdien Visser, Kwadwo M L Buabeng, Ankie Poutsma, Roel C van der Schors, Cees B M Oudejans
LINC-HELLP, showing chromosomal linkage with the pregnancy-specific HELLP syndrome in Dutch families, reduces differentiation from a proliferative to an invasive phenotype of first-trimester extravillous trophoblasts. Here we show that mutations in LINC-HELLP identified in HELLP families negatively affect this trophoblast differentiation either by inducing proliferation rate or by causing cell cycle exit as shown by a decrease in both proliferation and invasion. As LincRNAs predominantly function through interactions with proteins, we identified the directly interacting proteins using chromatin isolation by RNA purification followed by protein mass spectrometry...
October 1, 2015: Human Molecular Genetics
Ankie C M Hazen, Vivianne M Sloeserwij, Dorien L M Zwart, Antoinette A de Bont, Marcel L Bouvy, Johan J de Gier, Niek J de Wit, Anne J Leendertse
BACKGROUND: In the Netherlands, 5.6 % of acute hospital admissions are medication-related. Almost half of these admissions are potentially preventable. Reviewing medication in patients at risk in primary care might prevent these hospital admissions. At present, implementation of medication reviews in primary care is suboptimal: pharmacists lack access to patient information, pharmacists are short of clinical knowledge and skills, and working processes of pharmacists (focus on dispensing) and general practitioners (focus on clinical practice) match poorly...
2015: BMC Family Practice
Leti van Bodegom-Vos, Veronique M Voorn, Cynthia So-Osman, Thea P Vliet Vlieland, Albert Dahan, Ankie W Koopman-van Gemert, Stephan B Vehmeijer, Rob G Nelissen, Perla J Marang-van de Mheen
BACKGROUND: Cell salvage is used to reduce allogeneic red blood-cell (RBC) transfusions in total hip arthroplasty (THA) and total knee arthroplasty (TKA). We performed a meta-analysis to assess the effectiveness of cell salvage to reduce transfusions in THA and TKA separately, and to examine whether recent trials change the conclusions from previous meta-analyses. METHODS: We searched MEDLINE through January 2013 for randomized clinical trials evaluating the effects of cell salvage in THA and TKA...
June 17, 2015: Journal of Bone and Joint Surgery. American Volume
Joanna K Polko, Jop A van Rooij, Steffen Vanneste, Ronald Pierik, Ankie M H Ammerlaan, Marleen H Vergeer-van Eijk, Fionn McLoughlin, Kerstin Gühl, Gert Van Isterdael, Laurentius A C J Voesenek, Frank F Millenaar, Tom Beeckman, Anton J M Peeters, Athanasius F M Marée, Martijn van Zanten
Upward leaf movement (hyponastic growth) is frequently observed in response to changing environmental conditions and can be induced by the phytohormone ethylene. Hyponasty results from differential growth (i.e. enhanced cell elongation at the proximal abaxial side of the petiole relative to the adaxial side). Here, we characterize Enhanced Hyponasty-d, an activation-tagged Arabidopsis (Arabidopsis thaliana) line with exaggerated hyponasty. This phenotype is associated with overexpression of the mitotic cyclin CYCLINA2;1 (CYCA2;1), which hints at a role for cell divisions in regulating hyponasty...
September 2015: Plant Physiology
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