Yin P Hung, Ivan Chebib, Miriam A Bredella, Emily A Berner, Quinn Taylor-Black, Edwin Choy, Gregory M Cote, Yen-Lin Chen, Shannon M MacDonald, Joseph H Schwab, Kevin A Raskin, Erik T Newman, Martin K Selig, Vikram Deshpande, Jason L Hornick, Santiago A Lozano-Calderón, G Petur Nielsen
Dedifferentiated chondrosarcoma is rare, aggressive, and microscopically bimorphic. How pathologic features such as the amounts of dedifferentiation affect prognosis remains unclear. We evaluated the percentages and sizes of dedifferentiation in a consecutive institutional series of dedifferentiated chondrosarcomas from 1999 to 2021. The statistical analysis included cox proportional hazard models and log-rank tests. Of the 67 patients (26 women, 41 men; age, 39 to >89 [median 61] years; 2 with Ollier disease), 58 presented de novo; 9 were identified with conventional chondrosarcomas 0...
March 2023: Modern Pathology