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https://www.readbyqxmd.com/read/28481944/a-consistent-and-potentially-exploitable-response-during-chondrogenesis-of-mesenchymal-stem-cells-from-osteoarthritis-patients-to-the-protein-encoded-by-the-susceptibility-gene-gdf5
#1
Madhushika Ratnayake, Maria Tselepi, Robert Bloxham, Frank Plöger, Louise N Reynard, John Loughlin
Osteoarthritis (OA) is a common joint disease characterised by the focal loss of the protective cartilage layer at the ends of the bones. It is painful, disabling, multifactorial and polygenic. The growth differentiation factor 5 gene GDF5 was one of the first reported OA susceptibility signals that showed consistent association to OA, with the transcript single nucleotide polymorphism (SNP) rs143383 demonstrating association in Asians and Europeans. The functional effect of the signal is reduced expression of the gene...
2017: PloS One
https://www.readbyqxmd.com/read/28423564/hypermethylation-of-the-chrdl1-promoter-induces-proliferation-and-metastasis-by-activating-akt-and-erk-in-gastric-cancer
#2
Yao-Fei Pei, Ya-Jing Zhang, Yao Lei, Ding-Wei Wu, Tong-Hui Ma, Xi-Qiang Liu
CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis. Herein, we report that CHRDL1 expression was significantly down-regulated in gastric cancer tissues and associated with poor survival. Clinic-pathological parameters demonstrated a close relationship between low CHRDL1 expression and metastasis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28287559/rapid-isolation-of-bmpr-ib-adipose-derived-stromal-cells-for-use-in-a-calvarial-defect-healing-model
#3
Clement D Marshall, Elizabeth R Zielins, Elizabeth A Brett, Charles P Blackshear, Michael S Hu, Tripp Leavitt, Leandra A Barnes, H Peter Lorenz, Michael T Longaker, Derrick C Wan
Invasive cancers, major injuries, and infection can cause bone defects that are too large to be reconstructed with preexisting bone from the patient's own body. The ability to grow bone de novo using a patient's own cells would allow bony defects to be filled with adequate tissue without the morbidity of harvesting native bone. There is interest in the use of adipose-derived stromal cells (ASCs) as a source for tissue engineering because these are obtained from an abundant source: the patient's own adipose tissue...
February 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28188849/endocytosis-contributes-to-bmp2-induced-smad-signalling-and-neuronal-growth
#4
Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeffe
Bone morphogenetic protein 2 (BMP2) is a neurotrophic factor which induces the growth of midbrain dopaminergic (DA) neurons in vitro and in vivo, and its neurotrophic effects have been shown to be dependent on activation of BMP receptors (BMPRs) and Smad 1/5/8 signalling. However, the precise intracellular cascades that regulate BMP2-BMPR-Smad-signalling-induced neurite growth remain unknown. Endocytosis has been shown to regulate Smad 1/5/8 signalling and differentiation induced by BMPs. However, these studies were carried out in non-neural cells...
March 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28188131/momelotinib-inhibits-acvr1-alk2-decreases-hepcidin-production-and-ameliorates-anemia-of-chronic-disease-in-rodents
#5
Malte Asshoff, Verena Petzer, Matthew R Warr, David Haschka, Piotr Tymoszuk, Egon Demetz, Markus Seifert, Wilfried Posch, Manfred Nairz, Pat Maciejewski, Peter Fowles, Christopher J Burns, Gregg Smith, Kay-Uwe Wagner, Guenter Weiss, J Andrew Whitney, Igor Theurl
Patients with myelofibrosis (MF) often develop anemia and frequently become dependent on red blood cell transfusions. Results from a phase 2 study for the treatment of MF with the Janus kinase1/2 (JAK1/2) inhibitor momelotinib (MMB) demonstrated that MMB treatment ameliorated anemia, unexpected for a JAK1/2 inhibitor, as erythropoietin-mediated JAK2 signaling is essential for erythropoiesis. Using a rat model of anemia of chronic disease (ACD), we now demonstrate that MMB treatment can normalize hemoglobin and red blood cell numbers...
February 10, 2017: Blood
https://www.readbyqxmd.com/read/28108032/disruption-of-the-sheep-bmpr-ib-gene-by-crispr-cas9-in-in%C3%A2-vitro-produced-embryos
#6
Xuemei Zhang, Wenrong Li, Yangsheng Wu, Xinrong Peng, Bian Lou, Liqin Wang, Mingjun Liu
BMPR-IB (also known as FecB) is a key candidate gene for the genetic control of sheep reproductive performance. Loss-of-function mutations in the sheep BMPR-IB gene lead to an increase in ovulation rate and consequently larger litter size. However, the BMPR-IB gene has been identified in only a few sheep breeds. To improve sheep reproduction through modification of the BMPR-IB gene, we designed an sgRNA to target the sheep BMPR-IB gene by using the CRISPR/Cas9 system. First, we performed gene editing by injecting Cas9/sgRNA into the cytoplasm of one-cell fertilized eggs...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27920998/short-term-organ-culture-of-mouse-ovary-in-the-medium-supplemented-with-bone-morphogenetic-protein-15-and-follicle-stimulating-hormone-a-morphological-hormonal-and-molecular-study
#7
Mojdeh Salehnia, Mojdeh Pajokh, Nassim Ghorbanmehr
BACKGROUND: Bone morphogenetic protein 15 (BMP15) is a growth factor derived from oocyte and is essential for in vivo ovarian follicular growth and in this study, its effects on the improvement of growth and development of follicles during in vitro culture of neonatal mouse ovaries was investigated. METHODS: Two week old mice were cultured for 7 days in the basic culture media with or without follicle stimulating hormone (FSH) and BMP15 as four experimental groups; FSH(-)/BMP15(-), FSH(+)/BMP15(-), FSH(-)/BMP15(+) and FSH(+)/BMP15(+)...
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27780042/immunoexpression-of-bmp-2-and-bmp-4-and-their-receptors-bmpr-ia-and-bmpr-ii-in-ameloblastomas-and-adenomatoid-odontogenic-tumors
#8
Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
OBJECTIVES: The present study evaluated the immunohistochemical expression of BMP-2 and BMP-4 and of their receptors (BMPR-IA and BMPR-II) in solid ameloblastoma (SA), unicystic ameloblastoma (UA) and adenomatoid odontogenic tumor (AOT) in order to obtain a better understanding of their role in the development and biological behavior of these tumors. DESIGN: This study analyzed these proteins in 30 cases of SA, 10 cases of UA, and 30 cases of AOT. Immunoexpression was evaluated in the parenchyma and stroma by attributing the following scores: 0, no stained cells; 1, ≤10%; 2, >10% and ≤25%; 3, >25% and ≤50%; 4, >50% and ≤75%...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27754275/sy-18-1-translational-research-in-pah
#9
Wook-Jin Chung
Pulmonary arterial hypertension (PAH) is a life-threatening disorder with a poor prognosis and causes pulmonary vascular remodeling accompanied with increased pulmonary arterial medial wall thickness and fibrosis, which leads to vascular and right ventricular (RV) dysfunction. Despite treatment with prostacyclin, endothelin antagonist, and phosphodiesterase-5 inhibitors the 1-year mortality rate of PAH still remains high. Recent registries, clinical trials, and basic researches have been increasing the knowledge of PAH and it would contribute to potential therapeutic strategies and better clinical outcome...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748860/bone-morphogenetic-protein%C3%A2-9-promotes-the-differentiation-of-mouse-spleen-macrophages-into-osteoclasts-via-the-alk1-receptor-and-erk-1-2-pathways-in%C3%A2-vitro
#10
Hai Li, Dahang Zhao, Shengjing Wang, Jing Ding, Li Zhao
It has been confirmed that bone morphogenetic protein-9 (BMP-9) promotes the differentiation of osteoblasts. However, the ways in which BMP‑9 exerts its effects on the differentiation of osteoclasts and bone resorption remain to be elucidated. The present study was designed to investigate the roles and the molecular mechanism of BMP‑9 on the proliferation and differentiation of osteoclast precursors in vitro. Mouse spleen macrophages (RAW 264.7 cells) were cultured in the presence of receptor activator for nuclear factor‑κb ligand (RANKL) in vitro...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27720933/activation-of-the-pro-migratory-bone-morphogenetic-protein-receptor-1b-gene-in-human-mda-mb-468-triple-negative-breast-cancer-cells-that-over-express-cyp2j2
#11
Sarah E Allison, Yongjuan Chen, Nenad Petrovic, Stefanie Zimmermann, Bjoern Moosmann, Mirko Jansch, Pei H Cui, Colin R Dunstan, Peter I Mackenzie, Michael Murray
Secondary metastases are the leading cause of mortality in patients with breast cancer. Cytochrome P450 (CYP) 2J2 (CYP2J2) is upregulated in many human tumors and generates epoxyeicosanoids from arachidonic acid that promote tumorigenesis and metastasis, but at present there is little information on the genes that mediate these actions. In this study MDA-MB-468 breast cancer cells were stably transfected with CYP2J2 (MDA-2J2 cells) and Affymetrix microarray profiling was undertaken. We identified 182 genes that were differentially expressed in MDA-2J2 cells relative to control (MDA-CTL) cells (log[fold of control] ≥2)...
October 5, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27660075/hnf-4alpha-negatively-regulates-hepcidin-expression-through-bmpr1a-in-hepg2-cells
#12
Wencai Shi, Heyang Wang, Xuan Zheng, Xin Jiang, Zheng Xu, Hui Shen, Min Li
Hepcidin synthesis is reported to be inadequate according to the body iron store in patients with non-alcoholic fatty liver disease (NAFLD) undergoing hepatic iron overload (HIO). However, the underlying mechanisms remain unclear. We hypothesize that hepatocyte nuclear factor-4α (HNF-4α) may negatively regulate hepcidin expression and contribute to hepcidin deficiency in NAFLD patients. The effect of HNF-4α on hepcidin expression was observed by transfecting specific HNF-4α small interfering RNA (siRNA) or plasmids into HepG2 cells...
September 23, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27643272/sy-18-1-translational-research-in-pah
#13
Wook-Jin Chung
Pulmonary arterial hypertension (PAH) is a life-threatening disorder with a poor prognosis and causes pulmonary vascular remodeling accompanied with increased pulmonary arterial medial wall thickness and fibrosis, which leads to vascular and right ventricular (RV) dysfunction. Despite treatment with prostacyclin, endothelin antagonist, and phosphodiesterase-5 inhibitors the 1-year mortality rate of PAH still remains high. Recent registries, clinical trials, and basic researches have been increasing the knowledge of PAH and it would contribute to potential therapeutic strategies and better clinical outcome...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27600293/inhibition-of-osteoblast-differentiation-by-aluminum-trichloride-exposure-is-associated-with-inhibition-of-bmp-2-smad-pathway-component-expression
#14
Xu Yang, Hui Huo, Chunyu Xiu, Miao Song, Yanfei Han, Yanfei Li, Yanzhu Zhu
Bone morphogenetic protein-2 (BMP-2)/Smad signaling pathway plays an important role in regulating osteoblast (OB) differentiation. OB differentiation is a key process of bone formation. Aluminum (Al) exposure inhibits bone formation and causes Al-induced bone disease. However, the mechanism is not fully understood. To investigate whether BMP-2/Smad signaling pathway is associated with OB differentiation in aluminum trichloride (AlCl3)-treated OBs, the primary rat OBs were cultured and exposed to 0 (control group, CG), 1/40 IC50 (low-dose group, LG), 1/20 IC50 (mid-dose group, MG), and 1/10 IC50 (high-dose group, HG) of AlCl3 for 24 h, respectively...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27552226/the-immunologic-properties-of-bone-morphogenic-protein-receptor-ib-positive-subpopulation-before-and-after-osteogenic-differentiation-in-mouse-dermis
#15
Jin-Guang He, Ting-Liang Wang, Tao Wang, Hua Xu, Yi Zhang, Jia-Sheng Dong
We have previously reported that human dermal bone morphogenic protein receptor (BMPR) IB positive subpopulation had a high osteogenic differentiation potential and may be a promising cell source for allogeneic bone tissue engineering. In this study, the immunologic properties of dermal BMPR-IB+ subpopulation before and after osteogenic differentiation were reported. The results confirmed that dermal BMPR-IB+ cells possessed a similar osteogenic differentiation potential with bone marrow mesenchymal stromal cells in a mouse model...
2016: PloS One
https://www.readbyqxmd.com/read/27537724/extensive-pulmonary-sarcoid-reaction-in-a-patient-with-bmpr-2-associated-idiopathic-pulmonary-arterial-hypertension
#16
Evelien A J E Braam, Marian J R Quanjel, Jolanda H G M Van Haren-Willems, Matthijs F M Van Oosterhout, Aryan Vink, Yvonne F Heijdra, Johanna M Kwakkel-van Erp
Pulmonary arterial hypertension is a progressive life-threatening disease characterized by vascular remodeling. There is evidence that varied immune mechanism play an important role in progression of pulmonary hypertension.  We describe a case of a 35-year-old woman with idiopathic pulmonary arterial hypertension (IPAH) and a novel BMPR2 mutation, who underwent a successful lung transplantation.  Extensive granulomatous inflammation was seen in the resected lungs. The granulomatous inflammation found in the histology supports  a sarcoid-like reaction due to pulmonary hypertension in the context of the BMPR2 mutation...
August 1, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27430926/-bone-morphogenetic-protein-4-increases-canonical-transient-receptor-potential-protein-expression-by-activating-bone-morphogenetic-protein-receptor-%C3%A2-smad-signaling-pathways-in-pulmonary-arterial-smooth-muscle-cells
#17
X Y Li, P X Ran, J Wang
OBJECTIVE: To observe the effect of bone morphogenetic protein 4 (BMP4) on the Smad signaling pathway in rat distal pulmonary artery smooth muscle cells (PASMCs), and to explore the role of the transient receptor potential ion channel (TRPC) protein 1 and 6(TRPC1, 6) in rat distal PASMCs. METHODS: Distal pulmonary arteries were isolated from adult male Wistar rats(n=6, 280-300 g). The endothelium-denuded pulmonary artery tissue was digested using Collagenase and PASMCs were cultured...
July 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27429845/bmpr2-psmad1-5-signaling-pathway-regulates-runx2-expression-and-impacts-the-progression-of-dedifferentiated-chondrosarcoma
#18
Kang Yang, Xiao-Dong Tang, Wei Guo, Xiao-Long Xu, Ting-Ting Ren, Cong-Min Ren, Shi-Dong Wang, Xing Bao, Fan Zhang, Kun-Kun Sun
Bone morphogenetic protein receptors (BMPRs) are multifunctional proteins; they have indispensible roles in the process of BMP signaling. However, their function in dedifferentiated chondrosarcoma is uncertain. It has been reported that BMPR2 is associated with chondrosarcoma. Moreover, the detection of BMPR2 is more frequent in dedifferentiated chondrosarcomas (DDCS) than in conventional chondrosarcomas (CCS). BMPR2, phospho-SMAD1/5 (pSMAD1/5), and runt-related transcription factor 2 (RUNX2) expressions were found to be associated with the pathological grades of chondrosarcoma and could be a promising target of treatment outcome...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27406972/an-investigation-of-bmp-7-mediated-alterations-to-bmp-signalling-components-in-human-tenocyte-like-cells
#19
Franka Klatte-Schulz, Gerry Giese, Christopher Differ, Susann Minkwitz, Karen Ruschke, Regina Puts, Petra Knaus, Britt Wildemann
The incidence of tendon re-tears post-surgery is an ever present complication. It is suggested that the application of biological factors, such as bone morphogenetic protein 7 (BMP-7), can reduce complication rates by promoting tenogenic characteristics in in vitro studies. However, there remains a dearth of information in regards to the mechanisms of BMP-7 signalling in tenocytes. Using primary human tenocyte-like cells (hTLCs) from the supraspinatus tendon the BMP-7 signalling pathway was investigated: induction of the BMP associated Smad pathway and non-Smad pathways (AKT, p38, ERK1/2 and JNK); alterations in gene expression of BMP-7 associated receptors, Smad pathway components, Smad target gene (ID1) and tenogenic marker scleraxis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27401963/mntbap-increases-bmpr-ii-expression-in-endothelial-cells-and-attenuates-vascular-inflammation
#20
Qian Zhou, Michaela Einert, Hannah Schmitt, Zhengguan Wang, Franziska Pankratz, Christoph B Olivier, Christoph Bode, James K Liao, Martin Moser
AIMS: The endothelium plays an important role during vascular inflammation. Previous data have demonstrated a high expression level of manganese-superoxide dismutase (MnSOD) in endothelial cells and suggested an important role of MnSOD in several cardiovascular diseases. Manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) has been shown to mimic some of the effects of MnSOD and prevented the development of diabetes and obesity. However, its effect on vascular inflammation and the underlying mechanism is still unknown...
September 2016: Vascular Pharmacology
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