keyword
https://read.qxmd.com/read/38536940/death-anxiety-in-the-covid-19-pandemic-testing-rebt-models-of-psychopathology-and-psychological-health-of-death-anxiety
#1
JOURNAL ARTICLE
Elisa P Dumitru, Cardoș A I Roxana, Horea-Radu Oltean, Mirela I Bîlc, Daniel O David
Objective: This paper aimed to examine the validity of the death anxiety psychopathological and psychological health models of Rational-Emotive Behavior Therapy (REBT). We investigated whether irrational and rational beliefs were associated with death anxiety and if there are possible significant positive correlations between death anxiety and depression, anxiety, and stress. Method: A sample of 200 individuals completed online self-report measures and Structural Equation Modelling (SEM) was chosen to assess the validity of the REBT psychopathological model and the REBT psychological health model...
March 27, 2024: Psychological Reports
https://read.qxmd.com/read/38475386/highly-permeable-ultrafiltration-membranes-based-on-polyphenylene-sulfone-with-cardo-fragments
#2
JOURNAL ARTICLE
Alisa Raeva, Dmitry Matveev, Nikolay Bezrukov, Evgenia Grushevenko, Azamat Zhansitov, Zhanna Kurdanova, Kamila Shakhmurzova, Tatyana Anokhina, Svetlana Khashirova, Ilya Borisov
For the first time, copolymers of polyphenylene sulfone (PPSU) with cardo fragments of phenolphthalein (PP) were synthesized to develop highly permeable flat-sheet ultrafiltration membranes. By introducing cardo fragments into the polymer chain, we achieved a mechanical strength 1.3 times higher than the strength of commercial PPSU. It is shown that the introduction of the cardo monomer significantly increases the solubility of the polymer in aprotic solvents. The highest solubility is observed at the concentration of PP 50 mol...
March 5, 2024: Polymers
https://read.qxmd.com/read/38441704/exploring-the-range-of-culex-mosquitoes-in-western-argentinean-patagonia-unveiling-the-presence-of-culex-pipiens-bioform-pipiens-in-south-america
#3
JOURNAL ARTICLE
María Victoria Cardo, Alejandra Rubio, Aníbal Eduardo Carbajo, Darío Vezzani
Culicids in Argentinean Patagonia are characterized by low species diversity and adaptation to extreme environmental conditions, yet few studies have been conducted in the region. To further assess the occurrence of Culicidae in Western Patagonia, and in particular the presence of Culex pipiens bioforms at the southernmost extent of their distribution, immature and adult specimens were collected aboveground across various land uses located in shrubland, steppe, and deciduous forest between 38.96 and 46.55°S...
March 5, 2024: Parasitology Research
https://read.qxmd.com/read/38420017/evidence-of-spatial-clustering-of-childhood-acute-lymphoblastic-leukemia-cases-in-greater-mexico-city-report-from-the-mexican-inter-institutional-group-for-the-identification-of-the-causes-of-childhood-leukemia
#4
JOURNAL ARTICLE
David Aldebarán Duarte-Rodríguez, Janet Flores-Lujano, Richard J Q McNally, María Luisa Pérez-Saldivar, Elva Jiménez-Hernández, Jorge Alfonso Martín-Trejo, Laura Eugenia Espinoza-Hernández, Aurora Medina-Sanson, Rogelio Paredes-Aguilera, Laura Elizabeth Merino-Pasaye, Martha Margarita Velázquez-Aviña, José Refugio Torres-Nava, Rosa Martha Espinosa-Elizondo, Raquel Amador-Sánchez, Juan José Dosta-Herrera, Javier Anastacio Mondragón-García, Juana Esther González-Ulibarri, Sofía Irene Martínez-Silva, Gilberto Espinoza-Anrubio, María Minerva Paz-Bribiesca, Perla Salcedo-Lozada, Rodolfo Ángel Landa-García, Rosario Ramírez-Colorado, Luis Hernández-Mora, Marlene Santamaría-Ascencio, Anselmo López-Loyola, Arturo Hermilo Godoy-Esquivel, Luis Ramiro García-López, Alison Ireri Anguiano-Ávalos, Karina Mora-Rico, Alejandro Castañeda-Echevarría, Roberto Rodríguez-Jiménez, José Alberto Cibrian-Cruz, Karina Anastacia Solís-Labastida, Rocío Cárdenas-Cardos, Norma López-Santiago, Luz Victoria Flores-Villegas, José Gabriel Peñaloza-González, Ana Itamar González-Ávila, Martin Sánchez-Ruiz, Roberto Rivera-Luna, Luis Rodolfo Rodríguez-Villalobos, Francisco Hernández-Pérez, Jaime Ángel Olvera-Durán, Luis Rey García-Cortés, Minerva Mata-Rocha, Omar Alejandro Sepúlveda-Robles, Vilma Carolina Bekker-Méndez, Silvia Jiménez-Morales, Jorge Meléndez-Zajgla, Haydée Rosas-Vargas, Elizabeth Vega, Juan Carlos Núñez-Enríquez, Juan Manuel Mejía-Aranguré
BACKGROUND: A heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC). METHODS: A population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38352401/cooperativity-of-c-myc-with-kr%C3%A3-ppel-like-factor-6-splice-variant-1-induces-phenotypic-plasticity-and-promotes-prostate-cancer-progression-and-metastasis
#5
Sudeh Izadmehr, Heriberto Fernandez-Hernandez, Danica Wiredja, Alexander Kirschenbaum, Christine Lee-Poturalski, Peyman Tavassoli, Shen Yao, Daniela Schlatzer, Divya Hoon, Analisa Difeo, Alice C Levine, Juan-Miguel Mosquera, Matthew D Galsky, Carlos Cordon-Cardo, Goutham Narla
Metastasis remains a major cause of morbidity and mortality in men with prostate cancer, and the functional impact of the genetic alterations, alone or in combination, driving metastatic disease remains incompletely understood. The proto-oncogene c-MYC, commonly deregulated in prostate cancer. Transgenic expression of c-MYC is sufficient to drive the progression to prostatic intraepithelial neoplasia and ultimately to moderately differentiated localized primary tumors, however, c-MYC-driven tumors are unable to progress through the metastatic cascade, suggesting that a "second-hit" is necessary in the milieu of aberrant c-MYC-driven signaling...
February 1, 2024: bioRxiv
https://read.qxmd.com/read/38230954/ace2-and-tmprss2-distribution-in-the-respiratory-tract-of-different-animal-species-and-its-correlation-with-sars-cov-2-tissue-tropism
#6
JOURNAL ARTICLE
Mariano Carossino, Sudeh Izadmehr, Jessie D Trujillo, Natasha N Gaudreault, Wellesley Dittmar, Igor Morozov, Udeni B R Balasuriya, Carlos Cordon-Cardo, Adolfo García-Sastre, Juergen A Richt
SARS-CoV-2 infects a wide array of domestic and wild animals, raising concerns regarding its evolutionary dynamics in animals and potential for spillback transmission of emerging variants to humans. Hence, SARS-CoV-2 infection in animals has significant public health relevance. Host factors determining animal susceptibility to SARS-CoV-2 are vastly unknown, and their characterization is critical to further understand susceptibility and viral dynamics in animal populations and anticipate potential spillback transmission...
January 17, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38221391/the-systematics-of-the-pseudoscorpion-genus-indohya-pseudoscorpiones-hyidae-in-australia
#7
JOURNAL ARTICLE
Mark S Harvey, Mieke A A Burger, Kym M Abrams, Terrie L Finston, Joel A Huey, Giulia Perina
The pseudoscorpion genus Indohya Beier, 1974 is known to occur in three Gondwanan fragments around the Indian Oceansouthern India, Madagascar and north-western Australiasuggesting that the genus had evolved prior to the breakup of Gondwana and was present on each landmass as they rifted apart during the Mesozoic. The Australian fauna is the most diverse, with nine species previously described from Cape Range and the Kimberley region of north-western Australia. The present study documents the genus Indohya in Australia using a combination of morphology and DNA sequence data...
September 5, 2023: Zootaxa
https://read.qxmd.com/read/38207090/a-scoping-review-on-the-operationalization-of-intersectional-health-research-methods-in-studies-related-to-the-covid-19-pandemic
#8
JOURNAL ARTICLE
Adedoyin Olanlesi-Aliu, Mia Tulli, Janet Kemei, Glenda Bonifacio, Linda C Reif, Valentina Cardo, Hannah Roche, Natasha Hurley, Bukola Salami
PURPOSE: The COVID-19 pandemic began in early 2020 and became a global health crisis with devastating impacts. This scoping review maps the key findings of research about the pandemic that has operationalized intersectional research methods around the world. It also tracks how these studies have engaged with methodological tenets of oppression, comparison, relationality, complexity, and deconstruction. METHODS: Our search resulted in 14,487 articles, 5164 of which were duplicates, and 9297 studies that did not meet the inclusion criteria were excluded...
December 2024: International Journal of Qualitative Studies on Health and Well-being
https://read.qxmd.com/read/38198481/researching-covid-to-enhance-recovery-recover-tissue-pathology-study-protocol-rationale-objectives-and-design
#9
JOURNAL ARTICLE
Andrea B Troxel, Marie-Abele C Bind, Thomas J Flotte, Carlos Cordon-Cardo, Lauren A Decker, Aloke V Finn, Robert F Padera, R Ross Reichard, James R Stone, Natalie L Adolphi, Faye Victoria C Casimero, John F Crary, Jamie Elifritz, Arline Faustin, Saikat Kumar B Ghosh, Amanda Krausert, Maria Martinez-Lage, Jonathan Melamed, Roger A Mitchell, Barbara A Sampson, Alan C Seifert, Aylin Simsir, Cheryle Adams, Stephanie Haasnoot, Stephanie Hafner, Michelle A Siciliano, Brittany B Vallejos, Phoebe Del Boccio, Michelle F Lamendola-Essel, Chloe E Young, Deepshikha Kewlani, Precious A Akinbo, Brendan Parent, Alicia Chung, Teresa C Cato, Praveen C Mudumbi, Shari Esquenazi-Karonika, Marion J Wood, James Chan, Jonathan Monteiro, Daniel J Shinnick, Tanayott Thaweethai, Amber N Nguyen, Megan L Fitzgerald, Alice A Perlowski, Lauren E Stiles, Moira L Paskett, Stuart D Katz, Andrea S Foulkes
IMPORTANCE: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) tissue pathology study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC; (2) characterize the association of pathologic findings with clinical and other characteristics; (3) define the pathophysiology and mechanisms of PASC, and possible mediation via viral persistence; and (4) establish a post-mortem tissue biobank and post-mortem brain imaging biorepository...
2024: PloS One
https://read.qxmd.com/read/38132179/single-cell-transcriptomics-and-in-vitro-lineage-tracing-reveals-differential-susceptibility-of-human-ipsc-derived-midbrain-dopaminergic-neurons-in-a-cellular-model-of-parkinson-s-disease
#10
JOURNAL ARTICLE
Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng Li
Advances in stem cell technologies open up new avenues for modelling development and diseases. The success of these pursuits, however, relies on the use of cells most relevant to those targeted by the disease of interest, for example, midbrain dopaminergic neurons for Parkinson's disease. In the present study, we report the generation of a human induced pluripotent stem cell (iPSC) line capable of purifying and tracing nascent midbrain dopaminergic progenitors and their differentiated progeny via the expression of a Blue Fluorescent Protein (BFP)...
December 18, 2023: Cells
https://read.qxmd.com/read/38112065/blood-meal-sources-of-mosquitoes-diptera-culicidae-in-domestic-and-open-green-environments-from-two-urbanisations-of-temperate-argentina
#11
JOURNAL ARTICLE
Karelly Melgarejo-Colmenares, Darío Vezzani, Alejandra Gallego, María V Cardo
Understanding the blood-feeding patterns of mosquitoes is essential for evaluating their potential as disease vectors, especially in urban areas where mosquitoes coexist with humans, domestic animals and wildlife. This study aimed to bridge a substantial gap in regional knowledge by identifying the blood meal sources of field-collected mosquitoes in domestic and open green environments from two urbanisations of temperate Argentina, the Área Metropolitana de Buenos Aires (AMBA) and Tandil, using molecular techniques...
December 19, 2023: Bulletin of Entomological Research
https://read.qxmd.com/read/38044623/principles-of-health-equity-science-for-public-health-action
#12
JOURNAL ARTICLE
Deron C Burton, Angele Kelly, Denise Cardo, Demetre Daskalakis, David T Huang, Ana Penman-Aguilar, Pratima L Raghunathan, Bao-Ping Zhu, Rebecca Bunnell
No abstract text is available yet for this article.
December 3, 2023: Public Health Reports
https://read.qxmd.com/read/37995467/cellular-mechanisms-associated-with-sub-optimal-immune-responses-to-sars-cov-2-bivalent-booster-vaccination-in-patients-with-multiple-myeloma
#13
JOURNAL ARTICLE
Adolfo Aleman, Morgan van Kesteren, Ariel Kogan Zajdman, Komal Srivastava, Christian Cognigni, Jacob Mischka, Lucia Y Chen, Bhaskar Upadhyaya, Kseniya Serebryakova, Jessica R Nardulli, Neko Lyttle, Katerina Kappes, Hayley Jackson, Charles R Gleason, Annika Oostenink, Gianna Y Cai, Oliver Van Oekelen, Harm van Bakel, Emilia Mia Sordillo, Carlos Cordon-Cardo, Miriam Merad, Sundar Jagannath, Ania Wajnberg, Viviana Simon, Samir Parekh
BACKGROUND: The real-world impact of bivalent vaccines for wild type (WA.1) and Omicron variant (BA.5) is largely unknown in immunocompromised patients with Multiple Myeloma (MM). We characterize the humoral and cellular immune responses in patients with MM before and after receiving the bivalent booster, including neutralizing assays to identify patterns associated with continuing vulnerability to current variants (XBB1.16, EG5) in the current post-pandemic era. METHODS: We studied the humoral and cellular immune responses before and after bivalent booster immunization in 48 MM patients...
November 22, 2023: EBioMedicine
https://read.qxmd.com/read/37980969/corticodependent-and-recurrent-inflammatory-pseudotumor-analysis-of-cases-in-our-province-and-review
#14
REVIEW
Jaime Sanz-Cánovas, Gonzalo Lendínez-Sánchez, Elisa Prieto-Sánchez, Luis Vicioso-Recio, Antonio Gutiérrez-Cardo, Esther Izurrategui-Hidalgo, Sebastián Palacios-Rodríguez, José Miguel Peláez-Angulo, Guillermo Ropero-Luis, Iván Pérez-de-Pedro, Ricardo Gómez-Huelgas, Fernando Salgado-Ordóñez
Inflammatory pseudotumor (IP) is an infrequent process with benign evolution in most cases whose etiology and pathogenesis are unknown. It usually affects young men and children, in whom the macroscopic lesion can mimic a malignant process, which is ruled out after biopsy. Therefore, the diagnosis of certainty is histological and treatment consists of corticosteroids, leaving resection for cases in which biopsy is not possible or in which it produces local complications. We present a case of an inflammatory pseudotumor with special corticodependence that began as a long-term periodic fever and splenic focal lesion that required splenectomy for its diagnosis and that, after decreasing the corticosteroid regimen, presented recurrences at the cerebellar and systemic level requiring the association of various immunosuppressants and rituximab to achieve remission...
November 17, 2023: American Journal of the Medical Sciences
https://read.qxmd.com/read/37856700/associations-of-maternal-educational-level-proximity-to-greenspace-during-pregnancy-and-gestational-diabetes-with-body-mass-index-from-infancy-to-early-adulthood-a-proof-of-concept-federated-analysis-in-18-birth-cohorts
#15
JOURNAL ARTICLE
Tim Cadman, Ahmed Elhakeem, Johan Lerbech Vinther, Demetris Avraam, Paula Carrasco, Lucinda Calas, Marloes Cardo, Marie-Aline Charles, Eva Corpeleijn, Sarah Crozier, Montserrat de Castro, Marisa Estarlich, Amanda Fernandes, Serena Fossatti, Dariusz Gruszfeld, Kathrin Gurlich, Veit Grote, Sido Haakma, Jennifer R Harris, Barbara Heude, Rae-Chi Huang, Jesús Ibarluzea, Hazel Inskip, Vincent Jaddoe, Berthold Koletzko, Veronica Luque, Yannis Manios, Giovenale Moirano, George Moschonis, Johanna Nader, Mark Nieuwenhuijsen, Anne-Marie Nybo Andersen, Rosie McEachen, Angela Pinot de Moira, Maja Popovic, Theano Roumeliotaki, Theodosia Salika, Loreto Santa Marina, Susana Santos, Sylvain Serbert, Evangelia Tzorovili, Marina Vafeiadi, Elvira Verduci, Martine Vrijheid, T G M Vrijkotte, Marieke Welten, John Wright, Tiffany C Yang, Daniela Zugna, Deborah Lawlor
International sharing of cohort data for research is important and challenging. We explored the feasibility of multi-cohort federated analyses by examining associations between three pregnancy exposures (maternal education, exposure to green vegetation and gestational diabetes) with offspring BMI from infancy to 17 years. We used data from 18 cohorts (n=206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13 and 14-17 years. Associations were estimated using linear regression via one-stage IPD meta-analysis using DataSHIELD...
October 19, 2023: American Journal of Epidemiology
https://read.qxmd.com/read/37842331/clinical-performance-of-a-quantitative-pan-genus-leishmania-real-time-pcr-assay-for-diagnosis-of-cutaneous-and-visceral-leishmaniasis
#16
JOURNAL ARTICLE
Juan David Ramírez, Liyong Cao, Adriana C Castillo-Castañeda, Luz Helena Patino, Martha S Ayala, Carlos Cordon-Cardo, Emilia Mia Sordillo, Alberto Paniz-Mondolfi
Leishmaniasis is a complex vector-borne disease caused by various Leishmania species, affecting humans and animals. Current diagnostic methods have limitations, leading to potential misdiagnosis. Therefore, there is an urgent need for specific and sensitive diagnostic tools. We evaluated the sensitivity of a quantitative real-time PCR (qPCR) assay targeting the 18S gene in diverse clinical sample matrices. The assay showed a wide dynamic range and a limit of detection (LoD) of 1 parasite equivalent per milliliter (eq-p/mL) for all tested species...
November 2023: Practical Laboratory Medicine
https://read.qxmd.com/read/37837827/-community-health-innovating-in-the-training-of-family-and-community-medicine-residents
#17
JOURNAL ARTICLE
Adrián Cardo-Miota, Blanca Valls-Pérez, Carmen Lineros-González, Mariano Hernán-García
OBJECTIVE: To know the opinions of the agents involved in the training of family and community medicine residents in order to improve the training process of the «Project to Support the Revitalization of Primary Care; Assets for Community Health» (PARAC) taking into account its adequacy, contextualization and the methodologies used. METHOD: Qualitative interpretative-explanatory study of phenomenological orientation, multilevel and multicenter, in which the opinion of the participants is analyzed...
October 12, 2023: Gaceta Sanitaria
https://read.qxmd.com/read/37756107/the-evolution-of-cystic-echinococcosis-in-humans-and-ruminants-in-portugal-a-one-health-approach
#18
JOURNAL ARTICLE
Ana Margarida Alho, Miguel Canhão Dias, Miguel Cardo, Pedro Aguiar, Luís Madeira de Carvalho
Cystic echinococcosis, also known as hydatid disease, is a significant parasitic zoonosis with public health implications, albeit often neglected. In Portugal, data on this zoonosis are scarce despite being a mandatory notifiable disease in both humans and animals. To assess the impact of cystic echinococcosis on both livestock and humans, we compiled data from slaughterhouse records of ruminants, human hospitalizations, and confirmed cases of human echinococcosis. Overall, a total of 298 cases of cystic echinococcosis were identified in ruminants slaughtered from national farms for human consumption in Portugal between 2008 and 2022, comprising 192 cases in ovines, 95 in bovines, and 11 in caprines...
September 21, 2023: Veterinary Sciences
https://read.qxmd.com/read/37753173/age-and-socio-economic-status-affect-dengue-and-covid-19-incidence-spatio-temporal-analysis-of-the-2020-syndemic-in-buenos-aires-city
#19
JOURNAL ARTICLE
Aníbal E Carbajo, María V Cardo, Martina Pesce, Luciana E Iummato, Pilar Bárcena Barbeira, María Soledad Santini, María Eugenia Utgés
In early 2020, Argentina experienced the worst dengue outbreak in its history, concomitant with first-to-date increasing COVID-19 cases. Dengue epidemics in temperate Argentina have already been described as spatially heterogeneous; in the previous 2016 outbreak, transmission occurred 7.3 times more frequently in slums compared to the rest of Buenos Aires City (CABA). These informal settlements have deficient sanitary conditions, precarious housing and high incidence of social vulnerabilities. The purpose of this work was to study the spatio-temporal patterns of the 2020 dengue epidemic in CABA in relation to socio-economic living conditions of its inhabitants and its interaction with the onset of COVID-19...
2023: PeerJ
https://read.qxmd.com/read/37676710/master-transcription-factor-reprograming-unleashes-selective-translation-promoting-castration-resistance-and-immune-evasion-in-lethal-prostate-cancer
#20
JOURNAL ARTICLE
Sandra Santasusagna, Shijia Zhu, Vijayakumar Jawalagatti, Marc Carceles-Cordon, Adam Ertel, Saioa Garcia-Longarte, Won-Min Song, Naoto Fujiwara, Peiyao Li, Isabel Mendizabal, Daniel P Petrylak, William Kevin Kelly, E Premkumar Reddy, Liguo Wang, Matthew J Schiewer, Amaia Lujambio, Jeffrey Karnes, Karen E Knudsen, Carlos Cordon-Cardo, Haidong Dong, Haojie Huang, Arkaitz Carracedo, Yujin Hoshida, Veronica Rodriguez-Bravo, Josep Domingo-Domenech
Signaling rewiring allows tumors survive therapy. Here we show that the decrease of the master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer (PCa) unleashes eukaryotic initiation factor 3B (eIF3B)-dependent translation reprograming of key mRNAs conferring resistance to androgen deprivation therapy (ADT) and promoting immune evasion. Mechanistically, MITF represses through direct promoter binding eIF3B, which in turn regulates the translation of specific mRNAs. Genome-wide eIF3B enhanced cross-linking immunoprecipitation sequencing (eCLIP-seq) showed specialized binding to a UC-rich motif present in subsets of 5'-UTRs...
September 7, 2023: Cancer Discovery
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