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María V Cardo, Alejandra Rubio, Melania Junges, Darío Vezzani, Aníbal E Carbajo
Given their medical and veterinary relevance, the members of the Pipiens Assemblage are a worldwide target of ecological research. The distribution of Culex pipiens s.s. and Cx. quinquefasciatus converge in Buenos Aires, Argentina, where hybrids have been detected. Each member of the assemblage exhibits a distinct eco-physiological behaviour that can affect its efficiency in pathogen transmission. Our aim was to identify the environmental drivers for the spatio-temporal distribution of each member, focusing on latitudinal and urbanisation gradients...
October 24, 2016: Memórias do Instituto Oswaldo Cruz
Amita Shukla-Dave, Mireia Castillo-Martin, Ming Chen, Jose Lobo, Nataliya Gladoun, Ana C Lorduy, Faisal M Khan, Vladimir Ponomarev, Zhengzi Yi, Weijia Zhang, Pier P Pandolfi, Hedvig Hricak, Carlos Cordon-Cardo
Increased polyamine synthesis is known to play an important role in prostate cancer. We aimed to explore its functional significance in prostate tumor initiation and its link to androgen receptor (AR) signaling. For this purpose, we generated a new cell line derived from normal epithelial prostate cells (RWPE-1) with overexpression of ornithine decarboxylase (ODC) and used it for in vitro and in vivo experiments. We then comprehensively analyzed the expression of the main metabolic enzymes of the polyamine pathway and spermine abundance in 120 well-characterized cases of human prostate cancer and high-grade prostate intraepithelial neoplasia (HGPIN)...
October 19, 2016: American Journal of Pathology
Allison Gilbert, Benoit Cardos
No abstract text is available yet for this article.
September 29, 2016: Journal of Emergency Medicine
A Batalla, E Coto, J Gómez, N Eirís, D González-Fernández, C Gómez-De Castro, E Daudén, M Llamas-Velasco, R Prieto-Perez, F Abad-Santos, G Carretero, F S García, Y B Godoy, L F Cardo, B Alonso, S Iglesias, P Coto-Segura
Polymorphisms at genes encoding proteins involved in the pathogenesis of psoriasis (Psor) or in the mechanism of action of biological drugs could influence the treatment response. Because the interleukin (IL)-17 family has a central role in the pathogenesis of Psor, we hypothesized that IL17RA variants could influence the response to anti-TNF drugs among Psor patients. To address this issue we performed a cross-sectional study of Psor patients who received the biological treatments for the first time, with a follow-up of at least 6 months...
September 27, 2016: Pharmacogenomics Journal
Jinghai Hu, Fei Ye, Miao Cui, Peng Lee, Chengguo Wei, Yuanyuan Hao, Xiaoqing Wang, Yanbo Wang, Zhihua Lu, Matthew Galsky, Russell McBride, Li Wang, Dongwen Wang, Carlos Cordon-Cardo, Chunxi Wang, David Y Zhang
This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival...
2016: PloS One
Guille Peguero, Helene C Muller-Landau, Patrick A Jansen, S Joseph Wright
: Identification of the mechanisms enabling stable coexistence of species with similar resource requirements is a central challenge in ecology. Such coexistence can be facilitated by species at higher trophic levels through complex multi-trophic interactions, a mechanism that could be compromised by ongoing defaunation. We investigated cascading effects of defaunation on Pachymerus cardo and Speciomerus giganteus, the specialized insect seed predators of the Neotropical palm Attalea butyracea, testing the hypothesis that vertebrate frugivores and granivores facilitate their coexistence...
September 9, 2016: Journal of Animal Ecology
Jorge Alfonso Martín-Trejo, Juan Carlos Núñez-Enríquez, Arturo Fajardo-Gutiérrez, Aurora Medina-Sansón, Janet Flores-Lujano, Elva Jiménez-Hernández, Raquel Amador-Sanchez, José Gabriel Peñaloza-Gonzalez, Francisco Javier Alvarez-Rodriguez, Victoria Bolea-Murga, Rosa Martha Espinosa-Elizondo, José de Diego Flores-Chapa, Maria Luisa Pérez-Saldivar, María Del Carmen Rodriguez-Zepeda, Elisa María Dorantes-Acosta, Nora Nancy Núñez-Villegas, Martha Margarita Velazquez-Aviña, José Refugio Torres-Nava, Nancy Carolina Reyes-Zepeda, César Raúl González-Bonilla, Luz Victoria Flores-Villegas, Angélica Rangel-López, Roberto Rivera-Luna, Rogelio Paredes-Aguilera, Rocío Cárdenas-Cardós, Armando Martínez-Avalos, Ana Elena Gil-Hernández, David Aldebarán Duarte-Rodríguez, Juan Manuel Mejía-Aranguré
The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient's age at diagnosis, gender, hospital of treatment, and socioeconomic status...
August 26, 2016: Leukemia & Lymphoma
Marcelo L Berthier, Núria Roé-Vellvé, Ignacio Moreno-Torres, Carles Falcon, Karl Thurnhofer-Hemsi, José Paredes-Pacheco, María J Torres-Prioris, Irene De-Torres, Francisco Alfaro, Antonio L Gutiérrez-Cardo, Miquel Baquero, Rafael Ruiz-Cruces, Guadalupe Dávila
Foreign accent syndrome (FAS) is a speech disorder that is defined by the emergence of a peculiar manner of articulation and intonation which is perceived as foreign. In most cases of acquired FAS (AFAS) the new accent is secondary to small focal lesions involving components of the bilaterally distributed neural network for speech production. In the past few years FAS has also been described in different psychiatric conditions (conversion disorder, bipolar disorder, and schizophrenia) as well as in developmental disorders (specific language impairment, apraxia of speech)...
2016: Frontiers in Human Neuroscience
María L Buil, Juan J F Cardo, Miguel A Esteruelas, Enrique Oñate
Square-planar alkylidyne and five-coordinate alkylidene mixed (i)Pr3P-Os-IPr (IPr = 1,3-bis(diisopropylphenyl)imidazolylidene) complexes have been discovered and characterized, and their formation has been rationalized. The cationic five-coordinate hydride-alkylidyne compounds [OsHX(≡CPh)(IPr)(P(i)Pr3)]OTf (X = Cl (1), F (4); OTf = CF3SO3) undergo deprotonation with KO(t)Bu to afford the trans-halide-alkylidyne square-planar derivatives OsX(≡CPh)(IPr)(P(i)Pr3) (X = Cl (2), F (5)). Oxidative addition of the C(sp)-H bond of phenylacetylene and methyl propiolate along the Cl-Os-CPh axis of 2 with the hydrogen atom directed to the alkylidyne leads to alkynyl-cis-hydride-alkylidyne intermediates, which rapidly evolve into the five-coordinate alkylidene complexes Os(C≡CR)Cl(═CHPh)(IPr)(P(i)Pr3) (R = Ph (6), CO2Me (7)) as a consequence of the migration of the hydride from the metal center to the Cα atom of the alkylidyne...
August 3, 2016: Journal of the American Chemical Society
Charles D Larsen, Michael D Larsen, Terri Ambrose, Robert Degano, Leonard Gallo, Vito A Cardo
Brookdale Hospital and Medical Center's Prenatal Care Assistance Program (PCAP) provides oral health education and treatment to expectant mothers from a minority, impoverished, high-risk population. A chart review examined dental records for 42 children of mothers who took PCAP training versus 49 children of mothers who did not. At age 2, the children of PCAP mothers had fewer dental caries, less severe dental caries and fewer extractions. When combining children at ages 2 and 3, results were statistically significant and clinically important...
April 2016: New York State Dental Journal
Marina Cardó-Vila, Serena Marchiò, Masanori Sato, Fernanda I Staquicini, Tracey L Smith, Julianna K Bronk, Guosheng Yin, Amado J Zurita, Menghong Sun, Carmen Behrens, Richard L Sidman, J Jack Lee, Waun K Hong, Ignacio I Wistuba, Wadih Arap, Renata Pasqualini
We previously isolated an IL-11-mimic motif (CGRRAGGSC) that binds to IL-11 receptor (IL-11R) in vitro and accumulates in IL-11R-expressing tumors in vivo. This synthetic peptide ligand was used as a tumor-targeting moiety in the rational design of BMTP-11, which is a drug candidate in clinical trials. Here, we investigated the specificity and accessibility of IL-11R as a target and the efficacy of BMTP-11 as a ligand-targeted drug in lung cancer. We observed high IL-11R expression levels in a large cohort of patients (n = 368)...
August 2016: American Journal of Pathology
Veronica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zúñiga-García, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia Martín-Martín, James David Sutherland, Pilar Sanchez-Mosquera, Laura Bozal-Basterra, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana Maria Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, Jason W Locasale, Roger R Gomis, Arkaitz Carracedo
Cellular transformation and cancer progression is accompanied by changes in the metabolic landscape. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewiring. Here we show that the transcriptional co-activator peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) suppresses prostate cancer progression and metastasis. A metabolic co-regulator data mining analysis unveiled that PGC1α is downregulated in prostate cancer and associated with disease progression...
June 2016: Nature Cell Biology
Bernardete Weber, Ângela C Bersch-Ferreira, Camila R Torreglosa, Maria B Ross-Fernandes, Jacqueline T da Silva, Andrea P Galante, Enilda de Sousa Lara, Rosana P Costa, Rafael M Soares, Alexandre B Cavalcanti, Emilio H Moriguchi, Neide M Bruscato, Josiele Kesties, Lilian Vivian, Marina Schumacher, Waldemar de Carli, Luciano M Backes, Bruna R Reolão, Milena P Rodrigues, Dúnnia M B Baldissera, Glaucia S Tres, Hugo R K Lisbôa, João B J Bem, Jose B C Reolão, Keyla L A L Deucher, Maiara Cantarelli, Aline Lucion, Daniela Rampazzo, Vanessa Bertoni, Rosileide S Torres, Adriana O L Verríssimo, Aldair S Guterres, Andrea F R Cardos, Dalva B S Coutinho, Mayara G Negrão, Mônica F A Alencar, Priscila M Pinho, Socorro N A A Barbosa, Ana P P F Carvalho, Maria I S Taboada, Sheila A Pereira, Raul V Heyde, Francisca E Z Nagano, Rebecca Baumgartner, Fernanda P Resende, Ranata Tabalipa, Ana C Zanini, Michael J R Machado, Hevila Araujo, Maria L V Teixeira, Gabriela C Souza, Priccila Zuchinali, Bianca M Fracasso, Karen Ulliam, Marina Schumacher, Moara Pierotto, Thamires Hilário, Daniele M O Carlos, Cintia G N C Cordeiro, Daniele A Carvalho, Marília S Gonçalves, Valdiana B Vasconcelos, Rosa Bosquetti, Raira Pagano, Marcelo L P Romano, César A Jardim, Bernardo N A de Abreu, Aline Marcadenti, Alessandra R Schmitt, Angela M V Tavares, Christiane C Faria, Flávia M Silva, Jaqueline S Fink, Raquel M El Kik, Clarice F Prates, Cristiane S Vieira, Elaine F Adorne, Ellen H Magedanz, Fernanda L Chieza, Ingrid S Silva, Joise M Teixeira, Eduardo P Trescastro, Lívia A Pellegrini, Jéssika C Pinto, Cristina T Telles, Antonio C S Sousa, Andreza S Almeida, Ariane A Costa, José A C Carmo, Juliana T Silva, Luciana V S Alves, Saulo O C Sales, Maria E M Ramos, Marilia C S Lucas, Monica Damiani, Patricia C Cardoso, Salvador S Ramos, Clenise F Dantas, Amanda G Lopes, Ana M P Cabral, Ana C A Lucena, Auriene L Medeiros, Bernardino B Terceiro, Neuma M F S Leda, Sandra R D Baía, Josilene M F Pinheiro, Alexandra N Cassiano, Andressa N L Melo, Anny K O Cavalcanti, Camila V S Souza, Dayanna J M Queiroz, Hercilla N C F Farias, Larissa C F Souza, Letícia S Santos, Luana R M Lima, Meg S Hoffmann, Átala S Silva Ribeiro, Daniel F Vasconcelos, Eliane S Dutra, Marina K Ito, José A F Neto, Alexsandro F Santos, Rosângela M L Sousa, Luciana Pereira P Dias, Maria T M A Lima, Victor G Modanesi, Adriana F Teixeira, Luciana C N C D Estrada, Paulo V G Modanesi, Adriana B L Gomes, Bárbara R S Rocha, Cristina Teti, Marta M David, Bruna M Palácio, Délcio G S Junior, Érica H S Faria, Michelle C F Oliveira, Rose M Uehara, Sandramara Sasso, Annie S B Moreira, Ana C A H Cadinha, Carla W M Pinto, Mariana P Castilhos, Mariana Costa, Cristiane Kovacs, Daniel Magnoni, Quênia Silva, Michele F C A Germini, Renata A da Silva, Aline S Monteiro, Karina G Dos Santos, Priscila Moreira, Fernanda C Amparo, Catharina C J Paiva, Soraia Poloni, Diana S Russo, Izabele V Silveira, Maria A Moraes, Mirena Boklis, Quinto I Cardoso, Annie S B Moreira, Aline M S Damaceno, Elisa M Santos, Glauber M Dias, Cláudia P S Pinho, Adrilene C Cavalcanti, Amanda S Bezerra, Andrey V Queiroga, Isa G Rodrigues, Tallita V Leal, Viviane Sahade, Daniele A Amaral, Diana S Souza, Givaldo A Araújo, Karine Curvello, Manuella Heine, Marília M S Barretto, Nailson A Reis, Sandra M L Vasconcelos, Danielly C Vieira, Francisco A Costa, Jessica M S Fontes, Juvenal G C Neto, Laís N P Navarro, Raphaela C Ferreira, Patrícia M Marinho, Renata Torres Abib, Aline Longo, Eduardo G Bertoldi, Lauren S Ferreira, Lúcia R Borges, Norlai A Azevedo, Celma M Martins, Juliana T Kato, Maria C O Izar, Marina T Asoo, Mariana D de Capitani, Valéria A Machado, Waléria T Fonzar, Sônia L Pinto, Kellen C Silva, Lúcia H A Gratão, Sheila D Machado, Susane R U de Oliveira, Josefina Bressan, Ana P S Caldas, Hatanne C F M Lima, Helen H M Hermsdorff, Tânia M Saldanha, Sílvia E Priore, Naoel H Feres, Adila de Queiroz Neves, Loanda M G Cheim, Nilma F Silva, Silvia R L Reis, Andreza M Penafort, Ana Paula O de Queirós, Geysa M N Farias, Mônica L P de Los Santos, Cíntia L Ambrozio, Cirília N Camejo, Cristiano P Dos Santos, Gabriela S Schirmann, Jorge L Boemo, Rosane E C Oliveira, Súsi M B Lima, Vera M S Bortolini, Cristina H Matos, Claiza Barretta, Clarice M Specht, Simone R de Souza, Cristina S Arruda, Priscila A Rodrigues, Otávio Berwanger
No abstract text is available yet for this article.
May 2016: American Heart Journal
Ana Collazo-Lorduy, Mireia Castillo-Martin, Li Wang, Vaibhav Patel, Gopa Iyer, Emmet Jordan, Hikmat Al-Ahmadie, Issa Leonard, William K Oh, Jun Zhu, Russell B McBride, Carlos Cordon-Cardo, David B Solit, John P Sfakianos, Matthew D Galsky
: Metastatic urachal carcinoma is a rare, understudied, and aggressive malignancy with limited treatment options. Histologically, urachal carcinomas resemble enteric adenocarcinomas and anecdotally respond to systemic therapies utilized in colorectal cancer. Targeted exome sequencing of archival primary tumor tissue from a patient with metastatic urachal cancer revealed EGFR amplification and wild-type KRAS. The patient was treated with cetuximab, a monoclonal antibody directed against EGFR, as a single agent, and achieved a response lasting more than 8 mo...
May 10, 2016: European Urology
María L Buil, Juan J F Cardo, Miguel A Esteruelas, Israel Fernández, Enrique Oñate
An entry to mixed phosphine-osmium-NHC polyhydride complexes is described, starting from the five-coordinate hydrido-alkylidyne compounds [OsHCl(≡CPh)(IPr)(PR3)]OTf (IPr = 1,3-bis(2,6-disopropylphenyl)imidazolylidene; OTf = CF3SO3; PR3 = P(i)Pr3 (1), PPh3 (2)). The experimental procedure involves the borylation of the Os-C triple bond of 1 and 2 with NaBH4 and the subsequent alcoholysis of the borylation products OsH2Cl(η(2)-H-BCH2Ph)(IPr)(PR3) (PR3 = P(i)Pr3 (3), PPh3 (4)) or OsH2(η(2):η(2):H2BCH2Ph)(IPr)(P(i)Pr3) (5)...
May 16, 2016: Inorganic Chemistry
Juan J Grau, Ricard Mesía, Maria de la Iglesia-Vicente, Estrelania S Williams, Miren Taberna, Miguel Caballero, Ana-Belen Larque, Jorge de la Oliva, Carlos Cordón-Cardo, Josep Domingo-Domenech
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) present different responses to chemotherapy and radiotherapy. One explanation may be the differences in the individual rates of stem cell-like cells. METHODS: We included patients with HNSCC and tumor progression or relapse. Tumor samples were obtained before and after primary chemotherapy, and immunohistochemical analyses were performed for CD44, HLA class I (HLA-I), pancytokeratin, and phosphorylated epidermal growth factor receptor (p-EGFR)...
2016: Oncology
Mireia Castillo-Martin, Tin Htwe Thin, Ana Collazo Lorduy, Carlos Cordon-Cardo
Immunohistochemistry (IHC) is an excellent technique used routinely to define the phenotype in pathology laboratories through the analysis of molecular expression in cells and tissues. The PTEN protein is ubiquitously expressed in the majority of human tissues, and allelic or complete loss of PTEN is frequently observed in different types of malignancies leading to an activation of the AKT/mTOR pathways. IHC-based analyses are best to determine the level of PTEN expression in histological samples, but not to assess partial or heterozygous deletions, for which FISH analyses are more appropriate...
2016: Methods in Molecular Biology
Tracey L Smith, Ziqiang Yuan, Marina Cardó-Vila, Carmen Sanchez Claros, Asha Adem, Min-Hui Cui, Craig A Branch, Juri G Gelovani, Steven K Libutti, Richard L Sidman, Renata Pasqualini, Wadih Arap
Patients with inoperable or unresectable pancreatic neuroendocrine tumors (NETs) have limited treatment options. These rare human tumors often express somatostatin receptors (SSTRs) and thus are clinically responsive to certain relatively stable somatostatin analogs, such as octreotide. Unfortunately, however, this tumor response is generally short-lived. Here we designed a hybrid adeno-associated virus and phage (AAVP) vector displaying biologically active octreotide on the viral surface for ligand-directed delivery, cell internalization, and transduction of an apoptosis-promoting tumor necrosis factor (TNF) transgene specifically to NETs...
March 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
Eleonora Dondossola, Andrey S Dobroff, Serena Marchiò, Marina Cardó-Vila, Hitomi Hosoya, Steven K Libutti, Angelo Corti, Richard L Sidman, Wadih Arap, Renata Pasqualini
Circulating cancer cells can putatively colonize distant organs to form metastases or to reinfiltrate primary tumors themselves through a process termed "tumor self-seeding." Here we exploit this biological attribute to deliver tumor necrosis factor alpha (TNF), a potent antitumor cytokine, directly to primary and metastatic tumors in a mechanism that we have defined as "tumor self-targeting." For this purpose, we genetically engineered mouse mammary adenocarcinoma (TSA), melanoma (B16-F10), and Lewis lung carcinoma cells to produce and release murine TNF...
February 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
Hitomi Hosoya, Andrey S Dobroff, Wouter H P Driessen, Vittorio Cristini, Lina M Brinker, Fernanda I Staquicini, Marina Cardó-Vila, Sara D'Angelo, Fortunato Ferrara, Bettina Proneth, Yu-Shen Lin, Darren R Dunphy, Prashant Dogra, Marites P Melancon, R Jason Stafford, Kohei Miyazono, Juri G Gelovani, Kazunori Kataoka, C Jeffrey Brinker, Richard L Sidman, Wadih Arap, Renata Pasqualini
A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery...
February 16, 2016: Proceedings of the National Academy of Sciences of the United States of America
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