keyword
https://read.qxmd.com/read/38519418/pulsed-field-ablation-technology-for-pulmonary-vein-and-left-atrial-posterior-wall-isolation-in-patients-with-persistent-atrial-fibrillation
#21
JOURNAL ARTICLE
Marco Schiavone, Francesco Solimene, Massimo Moltrasio, Michela Casella, Stefano Bianchi, Saverio Iacopino, Antonio Rossillo, Vincenzo Schillaci, Gaetano Fassini, Paolo Compagnucci, Armando Salito, Pietro Rossi, Pasquale Filannino, Ruggero Maggio, Sakis Themistoklakis, Claudio Pandozi, Francesco Caprioglio, Maurizio Malacrida, Antonio Dello Russo, Claudio Tondo
INTRODUCTION: Limited data exist on pulsed-field ablation (PFA) in patients with persistent atrial fibrillation (PeAF) undergoing left atrial posterior wall isolation (LAPWI). METHODS: The Advanced TecHnologies For SuccEssful AblatioN of AF in Clinical Practice (ATHENA) prospective registry included consecutive patients referred for PeAF catheter ablation at 9 Italian centers, treated with the FARAPULSETM -PFA system. The primary efficacy and safety study endpoints were the acute LAPWI rate, freedom from arrhythmic recurrences and the incidence of major periprocedural complications...
March 22, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38517963/non-steady-state-thermometry-with-optical-diffraction-tomography
#22
JOURNAL ARTICLE
Adarsh B Vasista, Bernard Ciraulo, Falko Schmidt, Jaime Ortega Arroyo, Romain Quidant
Label-free thermometry is a pivotal tool for many disciplines. However, most current approaches are only suitable for planar heat sources in steady state, thereby restricting the range of systems that can be reliably studied. Here, we introduce pump probe-based optical diffraction tomography (ODT) as a method to map temperature precisely and accurately in three dimensions (3D) at the single-particle level. To do so, we first systematically characterize the thermal landscape in a model system consisting of gold nanorods in a microchamber and then benchmark the results against simulations and quantitative phase imaging thermometry...
March 22, 2024: Science Advances
https://read.qxmd.com/read/38514779/roboem-automated-3d-flight-tracing-for-synaptic-resolution-connectomics
#23
JOURNAL ARTICLE
Martin Schmidt, Alessandro Motta, Meike Sievers, Moritz Helmstaedter
Mapping neuronal networks from three-dimensional electron microscopy (3D-EM) data still poses substantial reconstruction challenges, in particular for thin axons. Currently available automated image segmentation methods require manual proofreading for many types of connectomic analysis. Here we introduce RoboEM, an artificial intelligence-based self-steering 3D 'flight' system trained to navigate along neurites using only 3D-EM data as input. Applied to 3D-EM data from mouse and human cortex, RoboEM substantially improves automated state-of-the-art segmentations and can replace manual proofreading for more complex connectomic analysis problems, yielding computational annotation cost for cortical connectomes about 400-fold lower than the cost of manual error correction...
March 21, 2024: Nature Methods
https://read.qxmd.com/read/38514735/3d-geological-and-petrophysical-modeling-of-alam-el-bueib-formation-using-well-logs-and-seismic-data-in-matruh-field-northwestern-egypt
#24
JOURNAL ARTICLE
Walaa A Ali, Amr S Deaf, Taher Mostafa
There are several productive petroleum fields in the North Western Desert (WD) of Egypt, which received extensive investigations regarding their petroleum potential. However, a few studies tackled the Matruh Oil Field, which contains the oil prolific Early Cretaceous Alam El-Bueib Formation (AEB Fm) reservoir. The reservoir intervals of the AEB Fm show substantial lithological variations across the basin. Therefore, it is necessary to analyze the vertical and lateral distributions in terms of their lithological and petrophysical properties...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514692/bsi-mvs-multi-view-stereo-network-with-bidirectional-semantic-information
#25
JOURNAL ARTICLE
Ruiming Jia, Jun Yu, Zhenghui Hu, Fei Yuan
The basic principle of multi-view stereo (MVS) is to perform 3D reconstruction by extracting depth information from multiple views. Most current SOTA MVS networks are based on Vision Transformer, which usually means expensive computational complexity. To reduce computational complexity and improve depth map accuracy, we propose a MVS network with Bidirectional Semantic Information (BSI-MVS). Firstly, we design a Multi-Level Spatial Pyramid module to generate multiple layers of feature map for extracting multi-scale information...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38511905/combining-magnetic-resonance-fingerprinting-with-voxel-based-morphometric-analysis-to-reduce-false-positives-for-focal-cortical-dysplasia-detection
#26
JOURNAL ARTICLE
Zheng Ding, Siyuan Hu, Ting-Yu Su, Joon Yul Choi, Spencer Morris, Xiaofeng Wang, Ken Sakaie, Hiroatsu Murakami, Hans-Jürgen Huppertz, Ingmar Blümcke, Stephen Jones, Imad Najm, Dan Ma, Zhong Irene Wang
OBJECTIVE: We aim to improve focal cortical dysplasia (FCD) detection by combining high-resolution, three-dimensional (3D) magnetic resonance fingerprinting (MRF) with voxel-based morphometric magnetic resonance imaging (MRI) analysis. METHODS: We included 37 patients with pharmacoresistant focal epilepsy and FCD (10 IIa, 15 IIb, 10 mild Malformation of Cortical Development [mMCD], and 2 mMCD with oligodendroglial hyperplasia and epilepsy [MOGHE]). Fifty-nine healthy controls (HCs) were also included...
March 21, 2024: Epilepsia
https://read.qxmd.com/read/38509540/automatic-imrt-treatment-planning-through-fluence-prediction-and-plan-fine-tuning-for-nasopharyngeal-carcinoma
#27
JOURNAL ARTICLE
Wenwen Cai, Shouliang Ding, Huali Li, Xuanru Zhou, Wen Dou, Linghong Zhou, Ting Song, Yongbao Li
BACKGROUND: At present, the implementation of intensity-modulated radiation therapy (IMRT) treatment planning for geometrically complex nasopharyngeal carcinoma (NPC) through manual trial-and-error fashion presents challenges to the improvement of planning efficiency and the obtaining of high-consistency plan quality. This paper aims to propose an automatic IMRT plan generation method through fluence prediction and further plan fine-tuning for patients with NPC and evaluates the planning efficiency and plan quality...
March 20, 2024: Radiation Oncology
https://read.qxmd.com/read/38509385/increased-enhancer-promoter-interactions-during-developmental-enhancer-activation-in-mammals
#28
JOURNAL ARTICLE
Zhuoxin Chen, Valentina Snetkova, Grace Bower, Sandra Jacinto, Benjamin Clock, Atrin Dizehchi, Iros Barozzi, Brandon J Mannion, Ana Alcaina-Caro, Javier Lopez-Rios, Diane E Dickel, Axel Visel, Len A Pennacchio, Evgeny Z Kvon
Remote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here we investigate the three-dimensional (3D) conformation of enhancers during mammalian development by generating high-resolution tissue-resolved contact maps for nearly a thousand enhancers with characterized in vivo activities in ten murine embryonic tissues. Sixty-one percent of developmental enhancers bypass their neighboring genes, which are often marked by promoter CpG methylation...
March 20, 2024: Nature Genetics
https://read.qxmd.com/read/38508496/improving-3d-edge-detection-for-visual-inspection-of-mri-coregistration-and-alignment
#29
JOURNAL ARTICLE
Chris Rorden, Taylor Hanayik, Daniel R Glen, Roger Newman-Norlund, Chris Drake, Julius Fridriksson, Paul A Taylor
BACKGROUND: Visualizing edges is critical for neuroimaging. For example, edge maps enable quality assurance for the automatic alignment of an image from one modality (or individual) to another. NEW METHOD: We suggest that using the second derivative (difference of Gaussian, or DoG) provides robust edge detection. This method is tuned by size (which is typically known in neuroimaging) rather than intensity (which is relative). RESULTS: We demonstrate that this method performs well across a broad range of imaging modalities...
March 18, 2024: Journal of Neuroscience Methods
https://read.qxmd.com/read/38508294/precise-detection-of-awareness-in-disorders-of-consciousness-using-deep-learning-framework
#30
JOURNAL ARTICLE
Huan Yang, Hang Wu, Lingcong Kong, Wen Luo, Qiuyou Xie, Jiahui Pan, Wuxiu Quan, Lianting Hu, Dantong Li, Xuehai Wu, Huiying Liang, Pengmin Qing
Diagnosis of disorders of consciousness (DOC) remains a formidable challenge. Deep learning methods have been widely applied in general neurological and psychiatry disorders, while limited in DOC domain. Considering the successful use of resting-state functional MRI (rs-fMRI) for evaluating patients with DOC, this study seeks to explore the conjunction of deep learning techniques and rs-fMRI in precisely detecting awareness in DOC. We initiated our research with a benchmark dataset comprising 140 participants, including 76 unresponsive wakefulness syndrome (UWS), 25 minimally conscious state (MCS), and 39 Controls, from three independent sites...
March 18, 2024: NeuroImage
https://read.qxmd.com/read/38508291/fast-and-accessible-t2-mapping-using-off-resonance-corrected-despot2-with-application-to-3d-prostate
#31
JOURNAL ARTICLE
Ronal Coronado, Carlos Castillo-Passi, Cecilia Besa, Pablo Irarrazaval
PURPOSE: Most T1 and T2 mapping take long acquisitions or needs specialized sequences not widely accessible on clinical scanners. An available solution is DESPOT1/T2 (Driven equilibrium single pulse observation of T1/T2). DESPOT1/T2 uses Spoiled gradient-echo (SPGR) and balanced Steady-State Free Precession (bSSFP) sequences, offering an accessible and reliable way for 3D accelerated T1/T2 mapping. However, bSSFP is prone to off-resonance artifacts, limiting the application of DESPOT2 in regions with high susceptibility contrasts, like the prostate...
March 18, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38508126/dna-adductomics-aided-rapid-screening-of-genotoxic-impurities-using-nucleosides-and-3d-bioprinted-human-liver-organoids
#32
JOURNAL ARTICLE
Ying Li, Chen Xu, Xueting Zhou, Jinhong Li, Shiting Xu, Yuanbo Tu, Xue Mu, Jiajun Huang, Qing Huang, Lifeng Kang, Huaisong Wang, Mei Zhang, Yaozuo Yuan, Chunyong Wu, Junying Zhang
Current genotoxicity assessment methods are mainly employed to verify the genotoxic safety of drugs, but do not allow for rapid screening of specific genotoxic impurities (GTIs). In this study, a new approach for the recognition of GTIs has been proposed. It is to expose the complex samples to an in vitro nucleoside incubation model, and then draw complete DNA adduct profiles to infer the structures of potential genotoxic impurities (PGIs). Subsequently, the genotoxicity is confirmed in human by 3D bioprinted human liver organoids...
March 15, 2024: Talanta
https://read.qxmd.com/read/38508083/characterization-of-the-collagen-network-of-human-cheek-skin-using-ultrasonic-microscopy
#33
JOURNAL ARTICLE
Shiro Mukae, Yuki Ogura, Yusuke Hara
Dermal collagen is the most abundant component of human skin and has a network structure that regulates the mechanical properties of the skin. Therefore, non-invasive characterization of the collagen network would be beneficial for the evaluation of skin conditions. The microscopic substructures of the network, which are individual bundles and fibers, have been optically investigated. However, the macroscopic structure of the collagen network has not been assessed. To evaluate the dermal collagen network, we developed two new indicators, volume filling factor (VFF) and collagen fiber texture (CFT), to analyze three-dimensional echo intensity maps of high-frequency ultrasonic microscopy...
March 16, 2024: Ultrasonics
https://read.qxmd.com/read/38507384/neural-3d-scene-reconstruction-with-indoor-planar-priors
#34
JOURNAL ARTICLE
Xiaowei Zhou, Haoyu Guo, Sida Peng, Yuxi Xiao, Haotong Lin, Qianqian Wang, Guofeng Zhang, Hujun Bao
This paper addresses the challenge of reconstructing 3D indoor scenes from multi-view images. Many previous works have shown impressive reconstruction results on textured objects, but they still have difficulty in handling low-textured planar regions, which are common in indoor scenes. An approach to solving this issue is to incorporate planar constraints into the depth map estimation in multi-view stereo-based methods, but the per-view plane estimation and depth optimization lack both efficiency and multi-view consistency...
March 20, 2024: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://read.qxmd.com/read/38505725/potential-arrhythmic-substrate-of-atrial-fibrillation-at-the-left-atrial-diverticulum
#35
Takehiko Takayanagi
Catheter ablation therapy for persistent atrial fibrillation (PeAF) is both difficult and has limited outcomes. The mechanisms underlying the development and persistence of atrial fibrillation (AF) are not fully understood; therefore, ablation strategies are diverse. A 45-year-old man was referred to our hospital for persistent atrial fibrillation to undergo radiofrequency catheter insertion (RFCA). In the first session we conducted pulmonary vein isolation and additional linear ablation, including that of the roof line and posterior inferior line (posterior box lesion) as the stepwise ablation...
February 2024: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38503827/investigation-of-deep-learning-model-for-predicting-immune-checkpoint-inhibitor-treatment-efficacy-on-contrast-enhanced-computed-tomography-images-of-hepatocellular-carcinoma
#36
JOURNAL ARTICLE
Yasuhiko Nakao, Takahito Nishihara, Ryu Sasaki, Masanori Fukushima, Satoshi Miuma, Hisamitsu Miyaaki, Yuko Akazawa, Kazuhiko Nakao
Although the use of immune checkpoint inhibitors (ICIs)-targeted agents for unresectable hepatocellular carcinoma (HCC) is promising, individual response variability exists. Therefore, we developed an artificial intelligence (AI)-based model to predict treatment efficacy using pre-ICIs contrast-enhanced computed tomography (CT) imaging characteristics. We evaluated the efficacy of atezolizumab and bevacizumab in 43 patients at the Nagasaki University Hospital from 2020 to 2022 using the modified Response Evaluation Criteria in Solid Tumors...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38503728/in-section-click-it-detection-and-super-resolution-clem-analysis-of-nucleolar-ultrastructure-and-replication-in-plants
#37
JOURNAL ARTICLE
Michal Franek, Lenka Koptašíková, Jíří Mikšátko, David Liebl, Eliška Macíčková, Jakub Pospíšil, Milan Esner, Martina Dvořáčková, Jíří Fajkus
Correlative light and electron microscopy (CLEM) is an important tool for the localisation of target molecule(s) and their spatial correlation with the ultrastructural map of subcellular features at the nanometre scale. Adoption of these advanced imaging methods has been limited in plant biology, due to challenges with plant tissue permeability, fluorescence labelling efficiency, indexing of features of interest throughout the complex 3D volume and their re-localization on micrographs of ultrathin cross-sections...
March 19, 2024: Nature Communications
https://read.qxmd.com/read/38503083/fracture-load-in-double-keyhole-notch-pla-cu-2-o-nanocomposites-manufactured-via-compression-molding-and-3d-printing-an-experimental-and-numerical-study
#38
JOURNAL ARTICLE
Javad Khodadad Hatkeposhti, Naser Kordani, Mohammad Akbarzadeh Pasha, Ahmad Barari
Polylactic acid (PLA) polymer has garnered significant attention due to its biocompatibility. The incorporation of copper oxide (Cu2 O) nanoparticles into this polymer is expected to enhance its antibacterial, electrical, and thermal properties. This modification can potentially improve the performance of PLA in the fields of prosthetics manufacturing or printed circuit fabrication. However, the current research is rather focused on the mechanical properties of the PLA-Cu2 O nanocomposites. This research is thus aimed to analyze PLA-Cu2 O (97-3 wt%) nanocomposites with a double keyhole notch configuration both experimentally and numerically...
March 12, 2024: Journal of the Mechanical Behavior of Biomedical Materials
https://read.qxmd.com/read/38502884/enhanced-interstitial-fluid-extraction-and-rapid-analysis-via-vacuum-tube-integrated-microneedle-array-device
#39
JOURNAL ARTICLE
Yuanting Xie, Jinhua He, Wenqing He, Tayyaba Iftikhar, Chuangjie Zhang, Lei Su, Xueji Zhang
Advancing the development of point-of-care testing (POCT) sensors that utilize interstitial fluid (ISF) presents considerable obstacles in terms of rapid sampling and analysis. Herein, an innovative strategy is introduced that involves the use of a 3D-printed, hollow microneedle array patch (MAP), in tandem with a vacuum tube (VT) connected through a hose, to improve ISF extraction efficiency and facilitate expedited analysis. The employment of negative pressure by the VT allows the MAP device to effectively gather ≈18 µL of ISF from the dermis of a live rabbit ear within a concise period of 5 min...
March 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38502630/robust-shape-fitting-for-3d-scene-abstraction
#40
JOURNAL ARTICLE
Florian Kluger, Eric Brachmann, Michael Ying Yang, Bodo Rosenhahn
Humans perceive and construct the world as an arrangement of simple parametric models. In particular, we can often describe man-made environments using volumetric primitives such as cuboids or cylinders. Inferring these primitives is important for attaining high-level, abstract scene descriptions. Previous approaches for primitive-based abstraction estimate shape parameters directly and are only able to reproduce simple objects. In contrast, we propose a robust estimator for primitive fitting, which meaningfully abstracts complex real-world environments using cuboids...
March 19, 2024: IEEE Transactions on Pattern Analysis and Machine Intelligence
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