Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica Ewald, Jason C Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Renata Moravcova, Søs Skovsø, Aliya F Spigelman, Jocelyn E Manning Fox, James Lyon, Leanne Beet, Jianguo Xia, Francis C Lynn, Anna L Gloyn, Leonard J Foster, Patrick E MacDonald, James D Johnson
UNLABELLED: Population level variation and molecular mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized despite ramifications for personalized nutrition. Here, we define prototypical insulin secretion dynamics in response to the three macronutrients in islets from 140 cadaveric donors, including those diagnosed with type 2 diabetes. While islets from the majority of donors exhibited the expected relative response magnitudes, with glucose being highest, amino acid moderate, and fatty acid small, 9% of islets stimulated with amino acid and 8% of islets stimulated with fatty acids had larger responses compared with high glucose...
March 5, 2024: medRxiv