keyword
MENU ▼
Read by QxMD icon Read
search

SOS response

keyword
https://www.readbyqxmd.com/read/29655705/spatially-correlated-gene-expression-in-bacterial-groups-the-role-of-lineage-history-spatial-gradients-and-cell-cell-interactions
#1
Simon van Vliet, Alma Dal Co, Annina R Winkler, Stefanie Spriewald, Bärbel Stecher, Martin Ackermann
Gene expression levels in clonal bacterial groups have been found to be spatially correlated. These correlations can partly be explained by the shared lineage history of nearby cells, although they could also arise from local cell-cell interactions. Here, we present a quantitative framework that allows us to disentangle the contributions of lineage history, long-range spatial gradients, and local cell-cell interactions to spatial correlations in gene expression. We study pathways involved in toxin production, SOS stress response, and metabolism in Escherichia coli microcolonies and find for all pathways that shared lineage history is the main cause of spatial correlations in gene expression levels...
April 5, 2018: Cell Systems
https://www.readbyqxmd.com/read/29610148/the-interdependent-activation-of-son-of-sevenless-and-ras
#2
Pradeep Bandaru, Yasushi Kondo, John Kuriyan
The guanine-nucleotide exchange factor (GEF) Son-of-Sevenless (SOS) plays a critical role in metazoan signaling by converting Ras•GDP (guanosine diphosphate) to Ras•GTP (guanosine triphosphate) in response to tyrosine kinase activation. Structural studies have shown that SOS differs from other Ras-specific GEFs in that SOS is itself activated by Ras•GTP binding to an allosteric site, distal to the site of nucleotide exchange. The activation of SOS involves membrane recruitment and conformational changes, triggered by lipid binding, that open the allosteric binding site for Ras•GTP...
April 2, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29565279/overexpression-of-a-sbp-box-gene-vpsbp16-from-chinese-wild-vitis-species-in-arabidopsis-improves-salinity-and-drought-stress-tolerance
#3
Hongmin Hou, Hui Jia, Qin Yan, Xiping Wang
Salinity and drought are two major abiotic stresses that limit grape productivity. Responses to stress in grape are known to be regulated by several families of transcription factors. However, little is known about the role of grape Squamosa promoter binding protein (SBP)-box transcription factor genes in response to abiotic stress. To better understand the functions of the grape SBP-box genes in abiotic stress tolerance, a full-length complementary DNA (cDNA) sequence of the putative SBP-box transcription factor gene, VpSBP16 was amplified from Chinese wild grapevine Vitis pseudoreticulata clone "Baihe-35-1"...
March 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29547508/the-use-of-biosensors-to-explore-the-potential-of-probiotic-strains-to-reduce-the-sos-response-and-mutagenesis-in-bacteria
#4
Vladimir Anatolievich Chistyakov, Evgeniya Valer'evna Prazdnova, Maria Sergeevna Mazanko, Anzhelica Borisovna Bren
A model system based on the Escherichia coli MG1655 (pRecA-lux) Lux-biosensor was used to evaluate the ability of the fermentates of eight probiotic strains to reduce the SOS response stimulated by ciprofloxacin in bacteria and mutagenesis mediated by it. Preliminary attempts to estimate the chemical nature of active components of the fermentates were conducted.
March 16, 2018: Biosensors
https://www.readbyqxmd.com/read/29528570/quantitative-proteomic-analysis-of-staphylococcus-aureus-treated-with-punicalagin-a-natural-antibiotic-from-pomegranate-that-disrupts-iron-homeostasis-and-induces-sos
#5
Bret Cooper, Nazrul Islam, Yunfeng Xu, Hunter S Beard, Wesley M Garrett, Ganyu Gu, Xiangwu Nou
Staphylococcus aureus, a bacterial, food-borne pathogen of humans, can contaminate raw fruits and vegetables. While physical and chemical methods are available to control S. aureus, scientists are searching for inhibitory phytochemicals from plants. One promising compound from pomegranate is punicalagin, a natural antibiotic. To get a broader understanding of the inhibitory effect of punicalagin on S. aureus growth, we used high-throughput mass spectrometry and quantitative isobaric labeling to investigate the proteome of S...
March 12, 2018: Proteomics
https://www.readbyqxmd.com/read/29524923/petrol-and-diesel-exhaust-particles-accelerate-the-horizontal-transfer-of-plasmid-mediated-antimicrobial-resistance-genes
#6
Ye Zhang, April Z Gu, Tianyu Cen, Xiangyang Li, Dan Li, Jianmin Chen
Particles exhausted from petrol and diesel consumptions are major components of urban air pollution that can be exposed to human via direct inhalation or other routes due to atmospheric deposition into water and soil. Antimicrobial resistance is one of the most serious threats to modern health care. However, how the petrol and diesel exhaust particles affect the development and spread of antimicrobial resistance genes (ARGs) in various environments remain largely unknown. This study investigated the effects and potential mechanisms of four representative petrol and diesel exhaust particles, namely 97 octane petrol, 93 octane petrol, light diesel oil, and marine heavy diesel oil, on the horizontal transfer of ARGs between two opportunistic Escherichia coli (E...
March 7, 2018: Environment International
https://www.readbyqxmd.com/read/29515843/a-method-for-estimating-hill-function-based-dynamic-models-of-gene-regulatory-networks
#7
Faizan Ehsan Elahi, Ammar Hasan
Gene regulatory networks (GRNs) are quite large and complex. To better understand and analyse GRNs, mathematical models are being employed. Different types of models, such as logical, continuous and stochastic models, can be used to describe GRNs. In this paper, we present a new approach to identify continuous models, because they are more suitable for large number of genes and quantitative analysis. One of the most promising techniques for identifying continuous models of GRNs is based on Hill functions and the generalized profiling method (GPM)...
February 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29515658/chlortetracycline-and-florfenicol-induce-expression-of-genes-associated-with-pathogenicity-in-multidrug-resistant-salmonella-enterica-serovar-typhimurium
#8
Devin B Holman, Shawn M D Bearson, Bradley L Bearson, Brian W Brunelle
Background: Multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium ( S . Typhimurium) is a serious public health threat as infections caused by these strains are more difficult and expensive to treat. Livestock serve as a reservoir for MDR Salmonella , and the antibiotics chlortetracycline and florfenicol are frequently administrated to food-producing animals to treat and prevent various diseases. Therefore, we evaluated the response of MDR S . Typhimurium after exposure to these two antibiotics...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29491733/a-salt-overly-sensitive-pathway-member-from-brassica-juncea-bjsos3-can-functionally-complement-%C3%AE-atsos3-in-arabidopsis
#9
REVIEW
Kamlesh Kant Nutan, Gautam Kumar, Sneh Lata Singla-Pareek, Ashwani Pareek
Background: Salt Overly Sensitive (SOS) pathway is a well-known pathway in arabidopsis, essential for maintenance of ion homeostasis and thus conferring salt stress tolerance. In arabidopsis, the Ca2+ activated SOS3 interacts with SOS2 which further activates SOS1, a Na+/H+ antiporter, responsible for removing toxic sodium ions from the cells. In the present study, we have shown that these three components of SOS pathway, BjSOS1, BjSOS2 and BjSOS3 genes exhibit differential expression pattern in response to salinity and ABA stress in contrasting cultivars of Brassica...
January 2018: Current Genomics
https://www.readbyqxmd.com/read/29477117/sub-inhibitory-concentrations-of-heavy-metals-facilitate-the-horizontal-transfer-of-plasmid-mediated-antibiotic-resistance-genes-in-water-environment
#10
Ye Zhang, April Z Gu, Tianyu Cen, Xiangyang Li, Miao He, Dan Li, Jianmin Chen
Although widespread antibiotic resistance has been mostly attributed to the selective pressure generated by overuse and misuse of antibiotics, recent growing evidence suggests that chemicals other than antibiotics, such as certain metals, can also select and stimulate antibiotic resistance via both co-resistance and cross-resistance mechanisms. For instance, tetL, merE, and oprD genes are resistant to both antibiotics and metals. However, the potential de novo resistance induced by heavy metals at environmentally-relevant low concentrations (much below theminimum inhibitory concentrations [MICs], also referred as sub-inhibitory) has hardly been explored...
February 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29473442/hu-protein-is-involved-in-intracellular-growth-and-full-virulence-of-francisella-tularensis
#11
Pavla Stojkova, Petra Spidlova, Juraj Lenco, Helena Rehulkova, Lucie Kratka, Jiri Stulik
The nucleoid-associated HU proteins are small abundant DNA-binding proteins in bacterial cell which play an important role in the initiation of DNA replication, cell division, SOS response, control of gene expression and recombination. HU proteins bind to double stranded DNA non-specifically, but they exhibit high affinity to abnormal DNA structures as four-way junctions, gaps or nicks, which are generated during DNA damage. In many pathogens HU proteins regulate expression of genes involved in metabolism and virulence...
February 23, 2018: Virulence
https://www.readbyqxmd.com/read/29472899/exposure-to-sub-lethal-2-4-dichlorophenoxyacetic-acid-arrests-cell-division-and-alters-cell-surface-properties-in-escherichia-coli
#12
Supriya V Bhat, Belma Kamencic, André Körnig, Zinnat Shahina, Tanya E S Dahms
Escherichia coli is a robust, easily adaptable and culturable bacterium in vitro , and a model bacterium for studying the impact of xenobiotics in the environment. We have used correlative atomic force - laser scanning confocal microscopy (AFM-LSCM) to characterize the mechanisms of cellular response to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). One of the most extensively used herbicides world-wide, 2,4-D is known to cause hazardous effects in diverse non-target organisms. Sub-lethal concentrations of 2,4-D caused DNA damage in E...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29440291/small-molecule-mediated-activation-of-ras-elicits-biphasic-modulation-of-phospho-erk-levels-that-are-regulated-through-negative-feedback-on-sos1
#13
Jennifer E Howes, Denis T Akan, Michael C Burns, Olivia W Rossanese, Alex G Waterson, Stephen W Fesik
Oncogenic mutation of RAS results in aberrant cellular signaling and is responsible for more than 30% of all human tumors. Therefore, pharmacological modulation of RAS has attracted great interest as a therapeutic strategy. Our laboratory has recently discovered small molecules that activate Son of Sevenless (SOS)-catalyzed nucleotide exchange on RAS and inhibit downstream signaling. Here we describe how pharmacologically targeting SOS1 induced biphasic modulation of RAS-GTP and ERK phosphorylation levels, which we observed in a variety of cell lines expressing different RAS mutant isoforms...
February 13, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29432559/glutamate-receptor-homolog3-4-is-involved-in-regulation-of-seed-germination-under-salt-stress-in-arabidopsis
#14
Yao Cheng, Xiuxiu Zhang, Tianyang Sun, Qiuying Tian, Wen-Hao Zhang
Seed germination is sensitive to salt stress, and abscisic acid (ABA) and Ca2+ are involved in the regulation of seed germination under salt stress. Ca2+ influx mediated by glutamate receptors (GLRs) plays important roles in many physiological processes in plants. Here, we investigated the correlation of GLRs, Ca2+ and ABA during seed germination in response to salt stress by using Arabidopsis thaliana wild-type and T-DNA insertion knockout mutants of glutamate receptors homolog3.4. We demonstrated that atglr3...
February 7, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29410519/rationale-and-design-of-an-inhibitor-of-reca-protein-as-an-inhibitor-of-acinetobacter-baumannii
#15
Vishvanath Tiwari, Monalisa Tiwari, Deepika Biswas
Acinetobacter baumannii is one of the ESKAPE pathogen, which causes pneumonia, urinary tract infections, and is linked to high degree of morbidity and mortality. One-way antibiotic and disinfectant resistance is acquired by the activation of RecA-mediated DNA repair (SOS-response) that maintain ROS-dependent DNA damage caused by these anti-bacterial molecules. To increase the efficacy of different anti-microbial, there is a need to design an inhibitor against RecA of A. baumannii. We have performed homology modeling to generate the structure of RecA, followed by model refinement and validation...
February 6, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29390081/construct-validity-of-the-societal-outreach-scale-sos
#16
David S Fike, Jason Denton, Matt Walk, Jennifer Kish, Ira Gorman
BACKGROUND: The American Physical Therapy Association (APTA) has been working toward a vision of increasing professional focus on societal level health. However, performance of social responsibility and related behaviors by physical therapists remains relatively poorly integrated into practice. Promoting a focus on societal outreach is necessary for all healthcare professionals to impact the health of their communities. OBJECTIVE: The objective was to document the validity of the 14-item Societal Outreach Scale (SOS) for use with practicing physical therapists...
January 30, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29378890/the-conserved-dna-binding-protein-whia-influences-chromosome-segregation-in-bacillus-subtilis
#17
Laura C Bohorquez, Katarina Surdova, Martijs J Jonker, Leendert W Hamoen
The DNA binding protein WhiA is conserved in Gram-positive bacteria, and is also present in the genetically simple, cell wall-lacking, mycoplasmas. The protein shows homology to eukaryotic homing endonucleases but lacks nuclease activity. WhiA was first characterized in streptomycetes, where it regulates expression of key differentiation genes, including the cell division gene ftsZ essential for sporulation. For Bacillus subtilis it was shown that WhiA is essential when certain cell division genes are deleted...
January 29, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29370801/expression-of-cocoa-genes-in-saccharomyces-cerevisiae-improves-cocoa-butter-production
#18
Yongjun Wei, David Bergenholm, Michael Gossing, Verena Siewers, Jens Nielsen
BACKGROUND: Cocoa butter (CB) extracted from cocoa beans (Theobroma cacao) is the main raw material for chocolate production, but CB supply is insufficient due to the increased chocolate demand and limited CB production. CB is mainly composed of three different kinds of triacylglycerols (TAGs), 1,3-dipalmitoyl-2-oleoyl-glycerol (POP, C16:0-C18:1-C16:0), 1-palmitoyl-3-stearoyl-2-oleoyl-glycerol (POS, C16:0-C18:1-C18:0) and 1,3-distearoyl-2-oleoyl-glycerol (SOS, C18:0-C18:1-C18:0). In general, Saccharomyces cerevisiae produces TAGs as storage lipids, which consist of C16 and C18 fatty acids...
January 25, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29351274/dna-polymerase-iv-primarily-operates-outside-of-dna-replication-forks-in-escherichia-coli
#19
Sarah S Henrikus, Elizabeth A Wood, John P McDonald, Michael M Cox, Roger Woodgate, Myron F Goodman, Antoine M van Oijen, Andrew Robinson
In Escherichia coli, damage to the chromosomal DNA induces the SOS response, setting in motion a series of different DNA repair and damage tolerance pathways. DNA polymerase IV (pol IV) is one of three specialised DNA polymerases called into action during the SOS response to help cells tolerate certain types of DNA damage. The canonical view in the field is that pol IV primarily acts at replisomes that have stalled on the damaged DNA template. However, the results of several studies indicate that pol IV also acts on other substrates, including single-stranded DNA gaps left behind replisomes that re-initiate replication downstream of a lesion, stalled transcription complexes and recombination intermediates...
January 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29329085/an-integrated-approach-to-assess-the-impacts-of-zinc-pyrithione-at-different-levels-of-biological-organization-in-marine-mussels
#20
Lorna J Dallas, Andrew Turner, Tim P Bean, Brett P Lyons, Awadhesh N Jha
The mechanisms of sublethal toxicity of the antifouling biocide, zinc pyrithione (ZnPT), have not been well-studied. This investigation demonstrates that 14-d sublethal exposure to ZnPT (0.2 or 2 μM, alongside inorganic Zn and sea water controls) is genotoxic to mussel haemocytes but suggests that this is not caused by oxidative DNA damage as no significant induction of oxidised purines was detected by Fpg-modified comet assay. More ecologically relevant endpoints, including decreased clearance rate (CR), cessation of attachment and decreased tolerance of stress on stress (SoS), also showed significant response to ZnPT exposure...
April 2018: Chemosphere
keyword
keyword
29501
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"