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SOS response

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https://www.readbyqxmd.com/read/28062853/antibacterial-and-antivirulence-effect-of-6-n-hydroxylaminopurine-in-listeria-monocytogenes
#1
Stefanie Sandra Krajewski, Isabelle Isoz, Jörgen Johansson
The emerging development of antibiotic resistant bacteria calls for novel types of antibacterial agents. In this work we examined the putative antibacterial effect of purine analogs in Listeria monocytogenes We show that, among several tested purine analogs, only 6-N-hydroxylaminopurine (6-N-HAP) reduces the viability of the Gram-positive pathogen Listeria monocytogenes As in Bacillus subtilis, 6-N-HAP terminates expression at guanine riboswitches in L. monocytogenes hence preventing expression of their downstream genes...
January 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28061766/chemotherapy-induced-sinusoidal-injury-csi-score-a-novel-histologic-assessment-of-chemotherapy-related-hepatic-sinusoidal-injury-in-patients-with-colorectal-liver-metastasis
#2
Heather L Stevenson, Mariana M Prats, Eizaburo Sasatomi
BACKGROUND: Preoperative neoadjuvant therapy for colorectal liver metastases (CRLM) is increasing in use and can lead to chemotherapy-induced damage to sinusoidal integrity, namely sinusoidal obstruction syndrome (SOS). SOS has been associated with an increased need for intraoperative blood transfusions, increased length of hospitalization post-surgery, decreased tumor response, and a shorter overall survival after resection due to liver insufficiency. It is critical for clinicians and pathologists to be aware of this type of liver injury, and for pathologists to include the status of the background, non-neoplastic liver parenchyma in their pathology reports...
January 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28052848/pseudomonas-aeruginosa-oligoribonuclease-contributes-to-tolerance-to-ciprofloxacin-by-regulating-pyocin-biosynthesis
#3
Fei Chen, Gukui Chen, Yiwei Liu, Yongxin Jin, Zhihui Cheng, Yang Liu, Liang Yang, Shouguang Jin, Weihui Wu
Bacterial oligoribonuclease (Orn) is a conserved 3' to 5' exonuclease. In Pseudomonas aeruginosa, it has been demonstrated that Orn plays a major role in the hydrolysis of pGpG which is required for c-di-GMP homeostasis. Meanwhile, Orn is involved in the degradation of nanoRNAs which can alter global gene expression by serving as transcription initiation primers. Previously, we found that Orn is required for the type III secretion system and pathogenesis of P. aeruginosa, indicating a role of Orn in bacterial response to environmental stimuli...
January 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28045041/relaxation-oscillations-and-hierarchy-of-feedbacks-in-mapk-signaling
#4
Marek Kochańczyk, Paweł Kocieniewski, Emilia Kozłowska, Joanna Jaruszewicz-Błońska, Breanne Sparta, Michael Pargett, John G Albeck, William S Hlavacek, Tomasz Lipniacki
We formulated a computational model for a MAPK signaling cascade downstream of the EGF receptor to investigate how interlinked positive and negative feedback loops process EGF signals into ERK pulses of constant amplitude but dose-dependent duration and frequency. A positive feedback loop involving RAS and SOS, which leads to bistability and allows for switch-like responses to inputs, is nested within a negative feedback loop that encompasses RAS and RAF, MEK, and ERK that inhibits SOS via phosphorylation. This negative feedback, operating on a longer time scale, changes switch-like behavior into oscillations having a period of 1 hour or longer...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039103/itraq-based-proteome-analysis-of-fluoroquinolone-resistant-staphylococcus-aureus
#5
Van Chi Thai, Teck Kwang Lim, Kim Phuong Uyen Le, Qingsong Lin, Thi Thu Hoai Nguyen
OBJECTIVES: The aim of this study was to compare global protein expression changes during fluoroquinolone (FQ) exposure of Staphylococcus aureus. METHODS: Total protein extracts of wild-type S. aureus ATCC 29213 and six multidrug-resistant (MDR) strains derived from the wild-type under different FQ exposures were analysed using the 8-plex isobaric tag for relative and absolute quantitation (iTRAQ) method combined with LC-MS/MS analysis. Differentially expressed proteins were searched for their Gene Ontology (GO) annotation (UniProt database) and protein-protein interaction network (STRING v...
December 27, 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28031197/ciprofloxacin-mediated-mutagenesis-is-suppressed-by-subinhibitory-concentrations-of-amikacin-in-pseudomonas-aeruginosa
#6
Estela Ynés Valencia, Fernanda Esposito, Beny Spira, Jesús Blázquez, Rodrigo S Galhardo
Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa.
December 28, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28013513/the-interaction-of-antimicrobial-peptides-with-the-membrane-and-intracellular-targets-of-staphylococcus-aureus-investigated-by-atp-leakage-dna-binding-analysis-and-the-expression-of-a-lexa-controlled-gene-reca
#7
Sanne Gottschalk, Line Elnif Thomsen
The analysis of how antimicrobial peptides (AMPs) interact with bacterial membranes and intracellular targets is important for our understanding of how these molecules affect bacteria. Increased knowledge may aid the design of AMPs that work on their target bacterium without inducing bacterial resistance. Here, we describe different methods to investigate the mode of action of peptides against the Gram-positive bacterium Staphylococcus aureus. ATP leakage analysis can be used to evaluate the ability of AMPs to perturb bacteria...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28000228/differential-regulation-of-ssb-genes-in-the-nitrogen-fixing-cyanobacterium-anabaena-sp-strain-pcc7120
#8
Anurag Kirti, Arvind Kumar, Hema Rajaram
Anabaena sp. PCC7120 possesses three genes coding for single-stranded DNA-binding (SSB) protein, of which ssb1 was a single gene, and ssb2 and ssb3, the first gene of their corresponding operons. Regulation of the truncated ssb genes, ssb1 (alr0088) and ssb2 (alr7559) were unaffected by N-status of growth. They were negatively regulated by the SOS-response regulatory protein LexA, as indicated by the (i) binding of Anabaena LexA to the LexA-box of regulatory regions of ssb1 and ssb2, and (ii) decreased expression of the downstream gfp reporter gene in E...
December 21, 2016: Journal of Phycology
https://www.readbyqxmd.com/read/27997135/subinhibitory-concentrations-of-disinfectants-promote-the-horizontal-transfer-of-multidrug-resistance-genes-within-and-across-genera
#9
Ye Zhang, April Z Gu, Miao He, Dan Li, Jianmin Chen
The greater abundances of antibiotic resistance genes (ARGs) in point-of-use tap and reclaimed water than that in freshly treated water raise the question whether residual disinfectants in distribution systems facilitate the spread of ARGs. This study investigated three widely used disinfectants (free chlorine, chloramine, and hydrogen peroxide) on promoting ARGs transfer within Escherichia coli strains and across genera from Escherichia coli to Salmonella typhimurium. The results demonstrated that subinhibitory concentrations (lower than minimum inhibitory concentrations [MICs]) of these disinfectants, namely 0...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27988975/response-of-vegetation-phenology-to-urbanization-in-the-conterminous-united-states
#10
Xuecao Li, Yuyu Zhou, Ghassem R Asrar, Jiafu Mao, Xiaoma Li, Wenyu Li
The influence of urbanization on vegetation phenology is gaining considerable attention due to its implications for human health, cycling of carbon and other nutrients in Earth system. In this study, we examined the relationship between change in vegetation phenology and urban size, an indicator of urbanization, for the conterminous United States. We studied more than 4500 urban clusters of varying size to determine the impact of urbanization on plant phenology, with the aids of remotely sensed observations since 2003-2012...
December 18, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27977665/hierarchical-post-transcriptional-regulation-of-colicin-e2-expression-in-escherichia-coli
#11
Matthias Lechner, Mathias Schwarz, Madeleine Opitz, Erwin Frey
Post-transcriptional regulation of gene expression plays a crucial role in many bacterial pathways. In particular, the translation of mRNA can be regulated by trans-acting, small, non-coding RNAs (sRNAs) or mRNA-binding proteins, each of which has been successfully treated theoretically using two-component models. An important system that includes a combination of these modes of post-transcriptional regulation is the Colicin E2 system. DNA damage, by triggering the SOS response, leads to the heterogeneous expression of the Colicin E2 operon including the cea gene encoding the toxin colicin E2, and the cel gene that codes for the induction of cell lysis and release of colicin...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27976011/sinapic-acid-as-inhibitor-of-the-sos-response-in-eschericha-coli-induced-by-ciprofloxacin
#12
L C Nascimento da Silva, S R Madsen, C Crocoll, B Halkier, A Løbner-Olesen
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27965652/identification-and-characterization-of-novel-compounds-blocking-shiga-toxin-expression-in-escherichia-coli-o157-h7
#13
Alejandro Huerta-Uribe, Zoe R Marjenberg, Nao Yamaguchi, Stephen Fitzgerald, James P R Connolly, Nuria Carpena, Hanna Uvell, Gillian Douce, Michael Elofsson, Olwyn Byron, Rudi Marquez, David L Gally, Andrew J Roe
Infections caused by Shiga toxin (Stx)-producing E. coli strains constitute a health problem, as they are problematic to treat. Stx production is a key virulence factor associated with the pathogenicity of enterohaemorrhagic E. coli (EHEC) and can result in the development of haemolytic uremic syndrome in infected patients. The genes encoding Stx are located on temperate lysogenic phages integrated into the bacterial chromosome and expression of the toxin is generally coupled to phage induction through the SOS response...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27957791/development-of-a-novel-index-for-electronically-excited-states-analysis
#14
Mojtaba Alipour, Samaneh Damiri
Concerning the leading factors in the context of excited states analyses, namely charge centroids of the orbitals involved in the excitations, distance between orbital centroids, and overlap integrals a new metric denominated as index is proposed to assign the characters and optical properties of electronically excited states. Using several molecules from different categories and also a well-studied standard database regarding time-dependent density functional theory (TD-DFT) studies as benchmark criteria, accountability of the developed index has numerically been assessed for local, charge transfer, and Rydberg excitations...
December 13, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27915231/predominant-role-of-dna-polymerase-eta-and-p53-dependent-translesion-synthesis-in-the-survival-of-ultraviolet-irradiated-human-cells
#15
Leticia K Lerner, Guilherme Francisco, Daniela T Soltys, Clarissa R R Rocha, Annabel Quinet, Alexandre T Vessoni, Ligia P Castro, Taynah I P David, Silvina O Bustos, Bryan E Strauss, Vanesa Gottifredi, Anne Stary, Alain Sarasin, Roger Chammas, Carlos F M Menck
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding continued stalling of replication forks, which could lead to cell death. p53 also plays an important role in preventing cell death after ultraviolet (UV) light exposure. Intriguingly, we show that p53 does so by favoring translesion DNA synthesis by pol eta. In fact, the p53-dependent induction of pol eta in normal and DNA repair-deficient XP-C human cells after UV exposure has a protective effect on cell survival after challenging UV exposures, which was absent in p53- and Pol H-silenced cells...
December 2, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27806931/the-mechanism-of-ros-regulation-of-antibiotic-resistance-and-antimicrobial-lethality
#16
Ma Lina, Mi Hongfei, Xue Yunxin, Wang Dai, Zhao Xilin
Misuse and overuse of antibiotics have led to serious resistance problems that pose a grave threat to human health. How to solve the increasing antibiotic resistance problem is a huge challenge. Besides the traditional strategy of developing novel antimicrobial agents, exploring ways to enhance the lethal activity of antibiotics currently available is another feasible approach to fight against resistance. Recent studies showed that ROS plays an important role in regulating both antibiotic resistance and antimicrobial lethality...
October 20, 2016: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/27800635/screening-of-genotoxicity-and-mutagenicity-in-extractable-organics-from-oil-sands-process-affected-water
#17
Nikolas C Zetouni, Arno G Siraki, Michael Weinfeld, Alberto Dos Santos Pereira, Jonathan W Martin
Large volumes of oil sands process-affected water (OSPW) are produced by the oil sands surface mining industry during alkaline hot-water extraction of bitumen. It is well documented that the acid extractable organics (AEOs) in OSPW, a highly complex mixture of acidic and polar neutral substances, are acutely toxic; but few studies have examined the genotoxicity or mutagenicity of this mixture. In the present study, the in vitro SOS Chromotest and the Ames test (TA98 and TA100 strains) were used to evaluate genotoxicity and mutagenicity for whole OSPW AEOs in the presence and absence of biotransformation by rat S9 liver enzymes...
November 1, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27790613/sending-out-an-sos-mitochondria-as-a-signaling-hub
#18
REVIEW
Iryna Bohovych, Oleh Khalimonchuk
Normal cellular physiology is critically dependent on numerous mitochondrial activities including energy conversion, cofactor and precursor metabolite synthesis, and regulation of ion and redox homeostasis. Advances in mitochondrial research during the last two decades provide solid evidence that these organelles are deeply integrated with the rest of the cell and multiple mechanisms are in place to monitor and communicate functional states of mitochondria. In many cases, however, the exact molecular nature of various mitochondria-to-cell communication pathways is only beginning to emerge...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27766091/molecular-interaction-and-cellular-location-of-reca-and-chew-proteins-in-salmonella-enterica-during-sos-response-and-their-implication-in-swarming
#19
Oihane Irazoki, Jesús Aranda, Timo Zimmermann, Susana Campoy, Jordi Barbé
In addition to its role in DNA damage repair and recombination, the RecA protein, through its interaction with CheW, is involved in swarming motility, a form of flagella-dependent movement across surfaces. In order to better understand how SOS response modulates swarming, in this work the location of RecA and CheW proteins within the swarming cells has been studied by using super-resolution microscopy. Further, and after in silico docking studies, the specific RecA and CheW regions associated with the RecA-CheW interaction have also been confirmed by site-directed mutagenesis and immunoprecipitation techniques...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27759504/sexual-pain-disorders-in-spanish-women-drug-users
#20
Francisco Javier Del Río, Francisco Cabello-Santamaría, Marina A Cabello-García, Jerónimo Aragón-Vela
BACKGROUND: The impact of pain in sexuality, couple relationships and the quality of life is very well known. OBJECTIVES: The relationship between substance abuse and the presence of sexual pain disorder is assessed, together with anxiety and sexual attitudes . METHOD: Two samples were selected. One sample for women with a history of substance abuse (n = 129), and another one of women nonconsumers (n = 129). The Golombok Rust Inventory of Sexual Satisfaction (GRISS), the Sexual Opinion Survey (SOS) and the State Trait Anxiety Inventory (STAI) questionnaires were used...
January 28, 2017: Substance Use & Misuse
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