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https://www.readbyqxmd.com/read/28724263/mutagenesis-and-characterization-of-a-bacillus-amyloliquefaciens-strain-for-cinnamomum-camphora-seed-kernel-oil-extraction-by-aqueous-enzymatic-method
#1
Cheng Zeng, Rongbin Zhao, Maomao Ma, Zheling Zeng, Deming Gong
The purpose of the present study was to increase the proteinase activity of the strain NCU116 by combining ultraviolet irradiation and N-methyl-N'-nitro-N-nitroso guanidine treatment, in order to enhance the efficiency of Cinnamomum camphora seed kernel oil (CCSKO) extraction by aqueous enzymatic method (AEM). The mutated strain, designated as NCU116-1, was screened out by the ratio of hydrolytic zone diameter to colony diameter on skim milk plate. The proteinase activity (9116.1 U/ml) of NCU116-1 was increased by 31...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28724222/development-of-a-soft-extraction-method-for-sulfamethoxazole-and-transformation-products-from-agricultural-soils-effects-of-organic-matter-co-extraction-on-the-environmental-availability-assessment
#2
Anaïs Goulas, Marjolaine Bourdat-Deschamps, Sylvie Nélieu, Julie Jimenez, Dominique Patureau, Claire-Sophie Haudin, Pierre Benoit
The recycling of biosolids and livestock manure in agriculture may lead to the introduction of antibiotic residues, i.e., parent molecule and transformation products, into amended soils. Their fate in soils can be approached through the assessment of their environmental availability. In this work, the environmental availability of sulfamethoxazole (SMX) and three transformation products (N(4)-acetyl-SMX, 3-amino-5-methylisoxazole, aniline) was assessed in soils amended with sludge compost or cow manure throughout a three-month incubation, using soft extractions with CaCl2, EDTA or cyclodextrin solutions...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724130/early-postimplant-speech-perception-and-language-skills-predict-long-term-language-and-neurocognitive-outcomes-following-pediatric-cochlear-implantation
#3
Cynthia R Hunter, William G Kronenberger, Irina Castellanos, David B Pisoni
Purpose: We sought to determine whether speech perception and language skills measured early after cochlear implantation in children who are deaf, and early postimplant growth in speech perception and language skills, predict long-term speech perception, language, and neurocognitive outcomes. Method: Thirty-six long-term users of cochlear implants, implanted at an average age of 3.4 years, completed measures of speech perception, language, and executive functioning an average of 14...
July 19, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28724088/in-vitro-and-in-vivo-assessment-of-aqueously-extractable-estrogens-in-poultry-manure-after-pilot-scale-composting
#4
Kirsten M Hammett, Elizabeth J Mullin, Diana S Aga, Gary K Felton, Daniel J Fisher, Lance T Yonkos
Poultry manure contains free and conjugated forms of the natural estrogens 17β-estradiol and estrone, which can be transported to receiving waters via runoff when land-applied. Previous studies have demonstrated estrogens in runoff from poultry manure-amended fields but have not tracked changes in estrogenicity within this water over time. Microbial conversion of conjugated estrogens (a major portion of water-extractable estrogens) to parent forms may result in temporary increases in estrogenicity in natural water bodies...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724066/strategies-for-selecting-crosses-using-genomic-prediction-in-two-wheat-breeding-programs
#5
Bettina Lado, Sarah Battenfield, Carlos Guzmán, Martín Quincke, Ravi P Singh, Susanne Dreisigacker, R Javier Peña, Allan Fritz, Paula Silva, Jesse Poland, Lucía Gutiérrez
The single most important decision in plant breeding programs is the selection of appropriate crosses. The ideal cross would provide superior predicted progeny performance and enough diversity to maintain genetic gain. The aim of this study was to compare the best crosses predicted using combinations of mid-parent value and variance prediction accounting for linkage disequilibrium (V) or assuming linkage equilibrium (V). After predicting the mean and the variance of each cross, we selected crosses based on mid-parent value, the top 10% of the progeny, and weighted mean and variance within progenies for grain yield, grain protein content, mixing time, and loaf volume in two applied wheat ( L...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724064/genetic-characterization-of-the-soybean-nested-association-mapping-population
#6
Qijian Song, Long Yan, Charles Quigley, Brandon D Jordan, Edward Fickus, Steve Schroeder, Bao-Hua Song, Yong-Qiang Charles An, David Hyten, Randall Nelson, Katy Rainey, William D Beavis, Jim Specht, Brian Diers, Perry Cregan
A set of nested association mapping (NAM) families was developed by crossing 40 diverse soybean [ (L.) Merr.] genotypes to the common cultivar. The 41 parents were deeply sequenced for SNP discovery. Based on the polymorphism of the single-nucleotide polymorphisms (SNPs) and other selection criteria, a set of SNPs was selected to be included in the SoyNAM6K BeadChip for genotyping the parents and 5600 RILs from the 40 families. Analysis of the SNP profiles of the RILs showed a low average recombination rate...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28723948/integrative-functional-analyses-using-rainbow-trout-selected-for-tolerance-to-plant-diets-reveal-nutrigenomic-signatures-for-soy-utilization-without-the-concurrence-of-enteritis
#7
Jason Abernathy, Andreas Brezas, Kevin R Snekvik, Ronald W Hardy, Ken Overturf
Finding suitable alternative protein sources for diets of carnivorous fish species remains a major concern for sustainable aquaculture. Through genetic selection, we created a strain of rainbow trout that outperforms parental lines in utilizing an all-plant protein diet and does not develop enteritis in the distal intestine, as is typical with salmonids on long-term plant protein-based feeds. By incorporating this strain into functional analyses, we set out to determine which genes are critical to plant protein utilization in the absence of gut inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28723930/does-culture-create-craving-evidence-from-the-case-of-menstrual-chocolate-craving
#8
Julia M Hormes, Martha A Niemiec
Craving is considered a key characteristic of diverse pathologies, but evidence suggests it may be a culture-bound construct. Almost 50% of American women crave chocolate specifically around the onset of menstruation. Research does not support popular accounts implicating physiological factors in menstrual chocolate craving etiology. We tested the novel hypothesis that greater menstrual craving prevalence in the U.S. is the product of internalized cultural norms. Women of diverse backgrounds (n = 275) reported on craving frequency and triggers and completed validated measures of acculturation...
2017: PloS One
https://www.readbyqxmd.com/read/28723929/clinical-utility-of-the-structured-observation-of-motor-performance-in-infants-within-the-child-health-services
#9
Kine Johansen, Kristina Persson, Karin Sonnander, Margaretha Magnusson, Anna Sarkadi, Steven Lucas
AIM: This study aimed to evaluate the clinical utility of the Structured Observation of Motor Performance in Infants (SOMP-I) when used by nurses in routine child healthcare by analyzing the nurses' SOMP-I assessments and the actions taken when motor problems were suspected. METHOD: Infants from three child health centers in Uppsala County, Sweden, were consecutively enrolled in a longitudinal study. The 242 infants were assessed using SOMP-I by the nurse responsible for the infant as part of the regular well-child visits at as close to 2, 4, 6 and 10 months of age as possible...
2017: PloS One
https://www.readbyqxmd.com/read/28723896/maternal-h3k27me3-controls-dna-methylation-independent-imprinting
#10
Azusa Inoue, Lan Jiang, Falong Lu, Tsukasa Suzuki, Yi Zhang
Mammalian sperm and oocytes have different epigenetic landscapes and are organized in different fashions. After fertilization, the initially distinct parental epigenomes become largely equalized with the exception of certain loci, including imprinting control regions. How parental chromatin becomes equalized and how imprinting control regions escape from this reprogramming is largely unknown. Here we profile parental allele-specific DNase I hypersensitive sites in mouse zygotes and morula embryos, and investigate the epigenetic mechanisms underlying these allelic sites...
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28723825/feasibility-of-conducting-autism-biomarker-research-in-the-clinical-setting
#11
Laura Sices, Katherine Pawlowski, Laura Farfel, Deirdre Phillips, Yamini Howe, David M Cochran, Roula Choueiri, Peter W Forbes, Stephanie J Brewster, Jean A Frazier, Ann Neumeyer, Carolyn Bridgemohan
OBJECTIVE: Recruitment and completion of research activities during regular clinical care has the potential to increase research participation in complex neurodevelopmental disorders. We evaluated the feasibility, and effect on clinical care, of conducting biomarker research within a subspecialty clinical visit for autism spectrum disorder (ASD). METHODS: Children, aged 5 to 10 years, were recruited by providers in ASD clinics at 5 institutions. Biomarkers collected were growth measurements, head circumference, neurologic and dysmorphology examinations, digit ratio (2D:4D) measurement, and platelet serotonin and urinary melatonin sulfate excretion levels...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28723824/a-national-profile-of-attention-deficit-hyperactivity-disorder-diagnosis-and-treatment-among-us-children-aged-2-to-5-years
#12
Melissa L Danielson, Susanna N Visser, Mary Margaret Gleason, Georgina Peacock, Angelika H Claussen, Stephen J Blumberg
OBJECTIVE: Clinical guidelines provide recommendations for diagnosis and treatment of attention-deficit hyperactivity disorder (ADHD), with specific guidance on caring for children younger than 6 years. This exploratory study describes ADHD diagnosis and treatment patterns among young children in the United States using 2 nationally representative parent surveys. METHODS: The National Survey of Children's Health (2007-2008, 2011-2012) was used to produce weighted prevalence estimates of current ADHD and ADHD medication treatment among US children aged 2 to 5 years...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28723823/association-between-television-viewing-and-parent-child-reading-in-the-early-home-environment
#13
Kiren S Khan, Kelly M Purtell, Jessica Logan, Arya Ansari, Laura M Justice
OBJECTIVE: This study examines whether there is an association between time spent by preschoolers in parent-child shared book reading versus TV viewing in two distinct samples. METHODS: Data were used from both the preschool wave of the Early Childhood Longitudinal Study Cohort, a nationally representative sample of 4-year-olds (N = 8900), as well as a low-income, rural sample of children enrolled in the Preschool Experience in Rural Classrooms study (N = 407). Information regarding frequency of shared book reading and daily TV consumption was obtained through caregiver report...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28723611/parent-reported-nutritional-risk-and-laboratory-indices-of-cardiometabolic-risk-and-in-preschool-aged-children
#14
Navindra Persaud, Hedyeh Ziai, Gerald Lebovic, Jonathon L Maguire, Marina Khovratovich, Janis A Randall Simpson, Khosrow Adeli, Jill Hamilton, Brian W McCrindle, Patricia C Parkin, Catherine S Birken
BACKGROUND: Eating habits formed during childhood may contribute to the increasing prevalence of cardiometabolic disorders. Assessing nutritional risk in young children may help to prevent later cardiometabolic disease. The objective of this study was to determine whether parent-reported nutritional risk in preschool-aged children was associated with laboratory indices of cardiometabolic risk, namely leptin and insulin. METHODS: In this cross-sectional study, the relationship between nutritional risk as determined by the parent-completed NutriSTEP® questionnaire was assessed and compared to the serum leptin and insulin concentrations, hormones involved in regulation of food intake and biomarkers of adiposity and cardiometabolic risk...
July 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28723588/shared-decision-making-with-parents-of-acutely-ill-children-a-narrative-review
#15
REVIEW
Paul L Aronson, Eugene D Shapiro, Linda M Niccolai, Liana Fraenkel
BACKGROUND: Shared decision-making (SDM) has mostly been used with adults and parents in the primary care setting, and there is limited knowledge on the use of SDM with parents of acutely ill children. OBJECTIVE: To review the literature on SDM with parents in the management of acutely ill children. DATA SOURCES: We searched MEDLINE, SCOPUS, PsycINFO, the Cochrane Library, and ClinicalTrials.gov for English language studies published from the time of database inception to February, 2017...
July 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28723580/quality-assurance-of-chemical-ingredient-classification-for-the-national-drug-file-reference-terminology
#16
Ling Zheng, Hasan Yumak, Ling Chen, Christopher Ochs, James Geller, Joan Kapusnik-Uner, Yehoshua Perl
The National Drug File - Reference Terminology (NDF-RT) is a large and complex drug terminology consisting of several classification hierarchies on top of an extensive collection of drug concepts. These hierarchies provide important information about clinical drugs, e.g., their chemical ingredients, mechanisms of action, dosage form and physiological effects. Within NDF-RT such information is represented using tens of thousands of roles connecting drugs to classifications. In previous studies, we have introduced various kinds of Abstraction Networks to summarize the content and structure of terminologies in order to facilitate their visual comprehension, and support quality assurance of terminologies...
July 16, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28722823/rational-design-of-a-highly-potent-and-selective-peptide-inhibitor-of-pace4-by-salt-bridge-interaction-with-d160-at-position-p3
#17
Vahid Dianati, Azar Shamloo, Anna Kwiatkowska, Roxane Desjardins, Armand Soldera, Robert Day, Yves L Dory
PACE4, a member of the proprotein convertases (PCs) family of serine proteases, is a validated target for prostate cancer. Our group has developed a potent and selective PACE4 inhibitor: Ac-LLLLRVKR-NH2 . In seeking for modifications to increase the selectivity of this ligand toward PACE4, we replaced one of its P3 Val methyl groups with a basic group capable of forming a salt bridge with D160 of PACE4. The resulting inhibitor is eight times more potent than the P3 Val parent inhibitor and two times more selective over furin, because the equivalent salt bridge with furin E257 is not optimal...
July 19, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28722705/background-controlled-qtl-mapping-in-pure-line-genetic-populations-derived-from-four-way-crosses
#18
S Zhang, L Meng, J Wang, L Zhang
Pure lines derived from multiple parents are becoming more important because of the increased genetic diversity, the possibility to conduct replicated phenotyping trials in multiple environments and potentially high mapping resolution of quantitative trait loci (QTL). In this study, we proposed a new mapping method for QTL detection in pure-line populations derived from four-way crosses, which is able to control the background genetic variation through a two-stage mapping strategy. First, orthogonal variables were created for each marker and used in an inclusive linear model, so as to completely absorb the genetic variation in the mapping population...
July 19, 2017: Heredity
https://www.readbyqxmd.com/read/28722644/children-diagnosed-with-auditory-processing-disorder-and-their-parents-a-qualitative-study-about-perceptions-of-living-with-apd
#19
Sarah Lawton, Suzanne C Purdy, Rose Thomas Kalathottukaren
BACKGROUND: Negative psychosocial consequences have been reported for children with auditory processing disorder (APD). The current literature surrounding APD does not sufficiently address the emotional and psychological consequences of living with the disorder. It is recommended that data be collected from multiple sources, including the child living with APD. Subjective reports of the perceptions of children with APD and their families have real-life validity and can inform clinical decisions and guide future research...
July 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28722606/assessment-of-the-acceptability-and-feasibility-of-child-potties-for-safe-child-feces-disposal-in-rural-bangladesh
#20
Faruqe Hussain, Stephen P Luby, Leanne Unicomb, Elli Leontsini, Tania Naushin, Audrey J Buckland, Peter J Winch
Indiscriminate defecation among young children and the unsafe disposal of their feces increases fecal contamination in the household environment and the risk of diarrheal disease transmission. Improved sanitary technology for children too young to use a latrine may facilitate safe feces disposal and reduce fecal contamination in the household environment. We assessed the acceptability and feasibility of child potties in rural Bangladesh in 2010. Our team introduced child potties into 26 households for 30 days, and conducted semistructured interviews, group discussions, and observations to assess the acceptability and feasibility of their use for parents and children...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
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