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https://www.readbyqxmd.com/read/29055241/comparing-parent-and-child-reports-of-health-related-quality-of-life-and-their-relationship-with-leisure-participation-in-children-and-adolescents-with-cerebral-palsy
#1
Egmar Longo, Marta Badia, M Begoña Orgaz, María Gómez-Vela
The aim of this study was to examine the level of agreement between reports of health-related quality of life (HR-QoL) obtained from children and adolescents with cerebral palsy (CP) and their parents. We also examined the relationships between child and parent perception of the different domains of HR-QoL and participation dimensions. Sixty-nine children and adolescents with CP and their parents separately completed parallel forms of the KIDSCREEN questionnaire. The Spanish version of the Children's Assessment of Participation and Enjoyment (CAPE) was completed by the child/adolescent...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29054985/caveolae-mediated-endocytosis-as-a-novel-mechanism-of-resistance-to-trastuzumab-emtansine-t-dm1
#2
Matthew Sung, Xingzhi Tan, Bingwen Lu, Jonathan Golas, Christine Hosselet, Fang Wang, Laurie Tylaska, Lindsay King, Dahui Zhou, Russell Dushin, Jeremy S Myers, Edward Rosfjord, Judy Lucas, Hans-Peter Gerber, Frank Loganzo
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that has demonstrated clinical benefit for patients with HER2+ metastatic breast cancer, however its clinical activity is limited by inherent or acquired drug resistance. The molecular mechanisms that drive clinical resistance to T-DM1, especially in HER2+ tumors, are not well understood. We used HER2+ cell lines to develop models of T-DM1 resistance utilizing a cyclical dosing schema in which cells received T-DM1 in an "on-off" routine until a T-DM1 resistant population was generated...
October 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29054980/one-year-language-outcomes-in-toddlers-with-language-delays-an-rct-follow-up
#3
Lauren H Hampton, Ann P Kaiser, Megan Y Roberts
OBJECTIVES: The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. METHODS: Toddlers with language delays were recruited from the community, and 97 toddlers and parents were randomly assigned to receive usual community treatments or a 3-month EMT intervention with parent training...
October 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29054936/a-case-of-autosplenectomy-associated-with-t-cell-checkpoint-inhibitor-treatment
#4
Rachel Delahunty, Margaret Lee, Mineesh Datta, Phillip Parente
No abstract text is available yet for this article.
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054818/parental-perception-of-child-weight-and-inflammation-perceived-overweight-is-associated-with-higher-child-c-reactive-protein
#5
Angelina R Sutin, George Rust, Eric Robinson, Michael Daly, Antonio Terracciano
Self-perceived overweight and weight discrimination are associated with inflammation in adulthood. We test whether there is an intergenerational association of parent perception of child overweight on higher levels of child c-reactive protein (CRP), a marker of inflammation implicated in stress. Data were from the National Health and Nutrition Examination Survey 2005-2014 (N=4,988). Parents reported their perception of their child's weight; CRP was assayed from children's blood samples. Children whose parents perceived them as overweight had higher CRP levels than children who were perceived about the right weight; perceived underweight was also associated with higher CRP (F(2,4977)=9...
October 17, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29054796/testosterone-social-status-and-parental-care-in-a-cooperatively-breeding-bird
#6
Alyxandra E Pikus, Sarah Guindre-Parker, Dustin R Rubenstein
The steroid hormone testosterone not only plays an important role in gamete production, but also influences social and aggressive behavior. Testosterone varies seasonally, peaking when competition for mates is high and declining during parental care. Surprisingly, little is known about how testosterone mediates social conflict and parental care behavior in highly social species like cooperative breeders, where group members compete for breeding opportunities and provide parental or alloparental care. We examined how testosterone differs across breeding roles in the tropical cooperatively breeding superb starling, Lamprotornis superbus...
October 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29054766/rethinking-genotype-phenotype-correlations-in-papillorenal-syndrome-a-case-report-on-an-unusual-congenital-camptodactyly-and-skeletal-deformity-with-a-heterogeneous-pax2-mutation-of-hexanucleotide-duplication
#7
Jiewei Liu, Ping Wang, Juan Huang, Zihua Yu
Papillorenal syndrome (PRS), an autosomal dominant inherited condition, is clinically featured by renal hypoplasia and optic nerve dysplasia. Based on current knowledge of genotype-phenotype correlations in PRS, mutations in the Paired box 2 (PAX2) gene have been recognized as a critical pathogenesis of typical renal and optic disease manifestations. However, little information is currently available on the skeletal abnormalities of PRS and the potential contribution of PAX2 mutations. Here, we present a case of a 10-year-old female PRS patient with the typical features of chronic renal failure and severe myopia, but was unexpectedly discovered camptodactyly of her left middle finger which affects the proximal interphalangeal joint...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054736/bidirectional-associations-between-adolescents-sexual-behaviors-and-psychological-well-being
#8
Raquel Nogueira Avelar E Silva, Daphne van de Bongardt, Laura Baams, Hein Raat
PURPOSE: Assessing bidirectional longitudinal associations between early sexual behaviors (≤16.0 years) and psychological well-being (global self-esteem, physical self-esteem, depression) among 716 adolescents, and the direct and buffering effect of parent-adolescent relationship quality. METHODS: We used data from Project STARS (Studies on Trajectories of Adolescent Relationships and Sexuality), a longitudinal study on adolescent sexual development in the Netherlands...
October 17, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29054727/evaluation-of-immune-responses-in-dogs-to-oral-rabies-vaccine-under-field-conditions
#9
Todd G Smith, Max Millien, Ad Vos, Franso A Fracciterne, Kelly Crowdis, Cornelius Chirodea, Alexandra Medley, Richard Chipman, Yunlong Qin, Jesse Blanton, Ryan Wallace
During the 20th century parenteral vaccination of dogs at central-point locations was the foundation of successful canine rabies elimination programs in numerous countries. However, countries that remain enzootic for canine rabies have lower infrastructural development compared to countries that have achieved elimination, which may make traditional vaccination methods less successful. Alternative vaccination methods for dogs must be considered, such as oral rabies vaccine (ORV). In 2016, a traditional mass dog vaccination campaign in Haiti was supplemented with ORV to improve vaccination coverage and to evaluate the use of ORV in dogs...
October 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29054706/quality-of-life-for-parents-of-children-with-food-allergy-in-peanut-restricted-versus-peanut-free-schools-in-the-united-states-and-canada
#10
Dipika R Patel, Julia E M Upton, Julie Wang, Laurie Harada, Danielle Guffey, Charles G Minard, Jordan Orange, Carla M Davis
No abstract text is available yet for this article.
October 17, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29054484/mental-health-and-well-being-among-type-1-diabetes-caregivers-in-india-evidence-from-the-idream-study
#11
Benjamin D Capistrant, Greta Friedemann-Sánchez, Lindsey K Novak, Caroline Zuijdwijk, Graham D Ogle, Sharad Pendsey
AIMS: Although more than half of the world's children with T1D live in developing countries, still little is known about how caregiving for children with T1D affects the parent/caregivers' health in low- and middle-income country settings. METHODS: Caregivers of 178 children with T1D from a specialized diabetes clinic in Maharashtra, India were surveyed. Ordered and standard logistic regression models adjusted for caregiver, household and child characteristics, were fit to estimate the association of caregiving burden (objective caregiving burden and subjective caregiving burden (Zarit Burden Inventory - tertiles)) with caregiver depression (Patient Health Questionnaire [PHQ-9]) and well-being (CDC Unhealthy Days) outcomes...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29054388/comparative-effectiveness-of-a-pilot-patient-centered-ultrasound-report-in-the-management-of-hydronephrosis
#12
Geolani W Dy, John L Gore, Wade W Muncey, Jonathan S Ellison, Paul A Merguerian
PURPOSE: Hydronephrosis is a common pediatric abnormality and can be associated with substantial parental anxiety, especially in the prenatal period. Radiology reports contain complex content that can be difficult for lay audiences to comprehend, potentially contributing to parental distress. MATERIALS AND METHODS: We developed and piloted a patient-centered radiology report (PCRR) for renal ultrasounds (US) in children with hydronephrosis (Figure). We obtained consensus from a multidisciplinary panel of experts regarding critical US report components...
September 28, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29054340/the-transmission-of-family-food-and-mealtime-practices-from-adolescence-to-adulthood-longitudinal-findings-from-project-eat-iv
#13
Allison Watts, Jerica M Berge, Katie Loth, Nicole Larson, Dianne Neumark-Sztainer
OBJECTIVE: To determine whether family food and mealtime practices experienced in adolescence are carried forward into parenthood. DESIGN: Baseline (Project Eating and Activity in Teens and Young Adults [EAT]-I) and 15-year follow-up (EAT-IV) survey data from a population-based cohort study (Project EAT). PARTICIPANTS: Cohort members identified as parents at follow-up (n = 727). To gain additional data about the practices of both parents in the household, significant others completed surveys at EAT-IV (n = 380)...
October 17, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29054099/examining-factors-associated-with-elevated-lie-scale-responding-on-the-child-abuse-potential-inventory
#14
Amanda H Costello, Natalie J Shook, Nancy M Wallace, Cheryl B McNeil
Child maltreatment remains a serious public health issue in the United States. Therefore, it is important to engage in quality control of the assessment, prevention, and treatment services for families affected by maltreatment. Parenting capacity assessments (PCAs) are typically an integral part of service delivery for families affected by maltreatment and can carry serious consequences for the referred parent. The Child Abuse Potential Inventory (CAPI) is a measure that is widely used in PCAs; however, socially desirable responding on the CAPI can serve to invalidate the important information derived from this assessment, as well as lead to negative impressions of the parent...
October 17, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29054091/early-adolescents-body-dysmorphic-symptoms-as-compensatory-responses-to-parental-appearance-messages-and-appearance-based-rejection-sensitivity
#15
Kelly Densham, Haley J Webb, Melanie J Zimmer-Gembeck, Drew Nesdale, Geraldine Downey
Body dysmorphic disorder (BDD) is marked by high distress and behavioral and functional impairments due to preoccupation with perceived appearance anomalies. Our aim was to examine parental correlates of offspring's symptoms characteristic of BDD, testing both direct associations and indirect associations via appearance-based rejection sensitivity (appearance-RS). Surveys were completed by 302 Australian adolescents (9-14 years) and their parents. Findings indicated parents' weight and appearance teasing and child-report (but not parent-report) of parental negative attitudes about weight and appearance were uniquely associated with offspring's heightened BDD-like symptoms, and associations were partially indirect via adolescents' appearance-RS...
October 17, 2017: Body Image
https://www.readbyqxmd.com/read/29054023/charting-the-territory-describing-the-functional-abilities-of-children-with-progressive-neurological-conditions
#16
Sandy K Tatla, Liisa Holsti, Gail Stephanie Andrews, Leanne Feichtinger, Rose Steele, Harold Siden
AIMS: Little is known about the functional abilities of children with progressive genetic, metabolic, or neurological conditions (PNCs). In this study, children with PNCs were followed over a 2-year period to assess their functional abilities over time. Specific aims were to: 1) describe the changes in functional skills and the effects of age for children with PNCs, 2) assess changes in these children's need for caregiver assistance over time, and 3) examine relationships between these children's functional skills and need for caregiver assistance...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29053989/psychometric-properties-of-the-child-anxiety-life-interference-scale-preschool-version
#17
Tamsyn J Gilbertson, Amy J Morgan, Ronald M Rapee, Heidi J Lyneham, Jordana K Bayer
Despite growing recognition of childhood anxiety as a common and often debilitating clinical concern, we have limited knowledge of the particular ways in which anxiety interferes with daily life for young children who have not yet entered formal schooling. The present study evaluated the psychometric properties of the Child Anxiety Life Interference Scale - Preschool Version (CALIS-PV). The CALIS-PV is a brief (18 item) parent-report measure of the impacts of a young child's anxiety on their own life and that of her or his parent...
October 13, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29053984/ecological-content-validation-of-the-information-assessment-method-for-parents-iam-parent-a-mixed-methods-study
#18
M Bujold, R El Sherif, P L Bush, J Johnson-Lafleur, G Doray, P Pluye
This mixed methods study content validated the Information Assessment Method for parents (IAM-parent) that allows users to systematically rate and comment on online parenting information. Quantitative data and results: 22,407 IAM ratings were collected; of the initial 32 items, descriptive statistics showed that 10 had low relevance. Qualitative data and results: IAM-based comments were collected, and 20 IAM users were interviewed (maximum variation sample); the qualitative data analysis assessed the representativeness of IAM items, and identified items with problematic wording...
October 4, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29053766/tor1a-variants-cause-a-severe-arthrogryposis-with-developmental-delay-strabismus-and-tremor
#19
Ariana Kariminejad, Martin Dahl-Halvarsson, Gianina Ravenscroft, Fariba Afroozan, Elham Keshavarz, Hayley Goullée, Mark R Davis, Mehrshid Faraji Zonooz, Hossein Najmabadi, Nigel G Laing, Homa Tajsharghi
Autosomal dominant torsion dystonia-1 is a disease with incomplete penetrance most often caused by an in-frame GAG deletion (p.Glu303del) in the endoplasmic reticulum luminal protein torsinA encoded by TOR1A. We report an association of the homozygous dominant disease-causing TOR1A p.Glu303del mutation, and a novel homozygous missense variant (p.Gly318Ser) with a severe arthrogryposis phenotype with developmental delay, strabismus and tremor in three unrelated Iranian families. All parents who were carriers of the TOR1A variant showed no evidence of neurological symptoms or signs, indicating decreased penetrance similar to families with autosomal dominant torsion dystonia-1...
September 23, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053669/the-other-end-of-the-leash-an-experimental-test-to-analyze-how-owners-interact-with-their-pet-dogs
#20
Giulia Cimarelli, Borbála Turcsán, Friederike Range, Zsófia Virányi
It has been suggested that the way in which owners interact with their dogs can largely vary and influence the dog-owner bond, but very few objective studies, so far, have addressed how the owner interacts with the dog. The goal of the present study was to record dog owners' interaction styles by means of objective observation and coding. The experiment included eight standardized situations in which owners of pet dogs were asked to perform specific tasks including both positive (i.e. playing, teaching a new task, showing a preference towards an object in a food searching task, greeting after separation) and potentially distressing tasks (i...
October 13, 2017: Journal of Visualized Experiments: JoVE
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