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https://www.readbyqxmd.com/read/29691120/neuroprotective-effect-of-nrf2-activator-dimethyl-fumarate-on-the-hippocampal-neurons-in-chemical-kindling-model-in-rat
#1
Neha Singh, Sheekha Vijayanti, Lekha Saha, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti
BACKGROUND: Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activator was explored in pentylenetetrazole (PTZ) induced kindling model of epilepsy in rats. METHODS: Male Wistar rats were subjected to different doses of DMF (15, 30, 60 mg/kg) to evaluate the effect on the PTZ induced kindling in rats...
April 21, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29684472/reserpine-induced-depression-is-associated-in-female-but-not-in-male-adolescent-rats-with-heightened-fluoxetine-sensitive-ethanol-consumption
#2
Paul Ruiz, Aldo Calliari, Ricardo Marcos Pautassi
Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1...
April 20, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29683209/inhibition-of-astroglial-connexin43-hemichannels-with-tat-gap19-exerts-anticonvulsant-effects-in-rodents
#3
Laura Walrave, Anouk Pierre, Giulia Albertini, Najat Aourz, Dimitri De Bundel, Ann Van Eeckhaut, Mathieu Vinken, Christian Giaume, Luc Leybaert, Ilse Smolders
Accumulating evidence shows a key function for astrocytic connexin43 (Cx43) signaling in epilepsy. However, the lack of experimental distinction between Cx43 gap junction channels (GJCs) and hemichannels (HCs) has impeded the identification of the exact contribution of either channel configurations to epilepsy. We therefore investigated whether TAT-Gap19, a Cx mimetic peptide that inhibits Cx43 HCs but not the corresponding Cx43 GJCs, influences experimentally induced seizures in rodents. Dye uptake experiments in acute hippocampal slices of mice demonstrated that astroglial Cx43 HCs open in response to the chemoconvulsant pilocarpine and this was inhibited by TAT-Gap19...
April 23, 2018: Glia
https://www.readbyqxmd.com/read/29677471/the-way-we-walked-with-immunology
#4
Kimishige Ishizaka
It has been a little more than 50 years since we discovered IgE, a key molecule for the allergic response and a target for treating allergies and severe asthma. Here, I trace my career, from the kindling of my interest in immunochemistry to groundbreaking discoveries in the biology and chemistry of immunoglobulins. I describe my service to the broader community of immunologists and my role in shaping departments and research institutes. My course starts in Japan and includes Southern California, Baltimore, and Denver...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29677029/kindlin-1-regulates-astrocyte-activation-and-pain-sensitivity-in-rats-with-neuropathic-pain
#5
Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Song
BACKGROUND AND OBJECTIVES: Astrocyte activation has been implicated in the pathogenesis of neuropathic pain, but the involvement of kindlin-1 in astrocyte activation and neuropathic pain has not yet been illustrated. Using a chronic constriction injury (CCI) rat model of neuropathic pain, we investigated the expression levels of kindlin-1 during neuropathic pain and the influences of kindlin-1 on regulating pain sensitivity. METHODS: Neuropathic pain was induced in rats by CCI of the sciatic nerve...
April 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29673861/il-6-knockout-mice-are-protected-from-cocaine-induced-kindling-behaviors-possible-involvement-of-jak2-stat3-and-pacap-signalings
#6
Huynh Nhu Mai, Yoon Hee Chung, Eun-Joo Shin, Naveen Sharma, Ji Hoon Jeong, Choon-Gon Jang, Kuniaki Saito, Toshitaka Nabeshima, Dora Reglodi, Hyoung-Chun Kim
IL-6 has been recognized as an anticonvulsant against certain neuroexcitotoxicities. We aimed to investigate on the interactive role between IL-6 and PACAP in cocaine-induced kindling behaviors. Although we found that cocaine (45 mg/kg, i.p./day x 5) significantly increased IL-6 and TNF-α expression, it resulted in a decrease in IFN-γ expression. We observed that the cocaine-induced increase in IL-6 expression was more pronounced than that in TNF-α expression. Genetic depletion of IL-6 significantly activated cocaine kindling behaviors...
April 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29663353/positron-emission-tomography-imaging-of-cerebral-glucose-metabolism-and-type-1-cannabinoid-receptor-availability-during-temporal-lobe-epileptogenesis-in-the-amygdala-kindling-model-in-rhesus-monkeys
#7
Evy Cleeren, Cindy Casteels, Karolien Goffin, Michel Koole, Koen Van Laere, Peter Janssen, Wim Van Paesschen
OBJECTIVE: We investigated changes in the endocannabinoid system and glucose metabolism during temporal lobe epileptogenesis. METHODS: Because it is rarely possible to study epileptogenesis in humans, we applied the electrical amygdala kindling model in nonhuman primates to image longitudinal changes in type 1 cannabinoid receptor (CB1R) binding and cerebral glucose metabolism. Two rhesus monkeys received [18 F]-MK-9470 and fluorodeoxyglucose-positron emission tomography ([18 F]-FDG -PET) scans in each of the 4 kindling stages to quantify relative changes over time of CB1R binding and cerebral glucose metabolism in vivo...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29618778/dynamic-interaction-of-local-and-transhemispheric-networks-is-necessary-for-progressive-intensification-of-hippocampal-seizures
#8
Fredrik Berglind, My Andersson, Merab Kokaia
The detailed mechanisms of progressive intensification of seizures often occurring in epilepsy are not well understood. Animal models of kindling, with progressive intensification of stimulation-induced seizures, have been previously used to investigate alterations in neuronal networks, but has been obscured by limited recording capabilities during electrical stimulations. Remote networks in kindling have been studied by physical deletions of the connected structures or pathways, inevitably leading to structural reorganisations and related adverse effects...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29609687/safranal-carried-by-nanostructured-lipid-vehicles-inhibits-generalized-epilepsy-in-mice
#9
Liu Bo-Qiang, Zhang Si-Tong, Lin Zu-Yuan, Nie Wan-Yun, Chen Bin, Lu Yuan, Li Xuyun, Mao Liangen, Chen You-Chao, Yin Xin-Zhen, Chen Zhong, Ying Xiao-Ying, Hu Wei-Wei
Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate...
April 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29602830/3%C3%AE-methyl-neurosteroid-analogs-are-preferential-positive-allosteric-modulators-and-direct-activators-of-extrasynaptic-%C3%AE-gaba-a-receptors-in-the-hippocampus-dentate-gyrus-subfield
#10
Shu-Hui Chuang, Doodipala Samba Reddy
Neurosteroids are powerful modulators of GABA-A receptors. Ganaxolone (3α-hydroxy-3β-methyl-5α-pregnan-20-one, GX) and synthetic analogs of the neurosteroid allopregnanolone (AP) are designed to treat epilepsy and related conditions. However, their precise mechanism of action in native neurons remains unclear. Here, we sought to determine the mode of action of GX and its analogs at GABA-A receptors in native hippocampal neurons by analyzing extrasynaptic receptor-mediated tonic currents and synaptic receptor-mediated phasic currents...
March 30, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29599784/disease-evolution-and-response-to-rapamycin-in-activated-phosphoinositide-3-kinase-%C3%AE-syndrome-the-european-society-for-immunodeficiencies-activated-phosphoinositide-3-kinase-%C3%AE-syndrome-registry
#11
Maria Elena Maccari, Hassan Abolhassani, Asghar Aghamohammadi, Alessandro Aiuti, Olga Aleinikova, Catherine Bangs, Safa Baris, Federica Barzaghi, Helen Baxendale, Matthew Buckland, Siobhan O Burns, Caterina Cancrini, Andrew Cant, Pascal Cathébras, Marina Cavazzana, Anita Chandra, Francesca Conti, Tanya Coulter, Lisa A Devlin, J David M Edgar, Saul Faust, Alain Fischer, Marina Garcia Prat, Lennart Hammarström, Maximilian Heeg, Stephen Jolles, Elif Karakoc-Aydiner, Gerhard Kindle, Ayca Kiykim, Dinakantha Kumararatne, Bodo Grimbacher, Hilary Longhurst, Nizar Mahlaoui, Tomas Milota, Fernando Moreira, Despina Moshous, Anna Mukhina, Olaf Neth, Benedicte Neven, Alexandra Nieters, Peter Olbrich, Ahmet Ozen, Jana Pachlopnik Schmid, Capucine Picard, Seraina Prader, William Rae, Janine Reichenbach, Stephan Rusch, Sinisa Savic, Alessia Scarselli, Raphael Scheible, Anna Sediva, Svetlana O Sharapova, Anna Shcherbina, Mary Slatter, Pere Soler-Palacin, Aurelie Stanislas, Felipe Suarez, Francesca Tucci, Annette Uhlmann, Joris van Montfrans, Klaus Warnatz, Anthony Peter Williams, Phil Wood, Sven Kracker, Alison Mary Condliffe, Stephan Ehl
Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous primary immunodeficiency. While initial cohort-descriptions summarized the spectrum of clinical and immunological manifestations, questions about long-term disease evolution and response to therapy remain. The prospective European Society for Immunodeficiencies (ESID)-APDS registry aims to characterize the disease course, identify outcome predictors, and evaluate treatment responses...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29599167/quality-of-life-in-young-people-with-congenital-heart-disease-is-better-than-expected
#12
Barbara Reiner, Renate Oberhoffer, Peter Ewert, Jan Müller
OBJECTIVES: Improved treatments for patients with congenital heart disease (CHD) have led to a growing interest in long-term functional outcomes such as health-related quality of life (HRQoL). Studies on HRQoL in children with CHD have contradicting results. Therefore, we compared HRQoL of children with CHD with that of current healthy peers and stratify CHD cases by severity and diagnostic subgroups. METHODS: We included 514 patients (191 girls) aged 7-17 (12.9±3...
March 29, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29597196/dermocosmetics-for-use-in-rosacea-guideline-of-the-society-for-dermopharmacy
#13
Joachim Kresken, Ursula Kindl, Walter Wigger-Alberti, Benjamin M Clanner-Engelshofen, Markus Reinholz
Rosacea is a widespread inflammatory skin disease that is chronically recurrent and affects predominately the central parts of the face. Affected individuals typically react to numerous cosmetics with redness, burning, and/or worsening of the complexion. Consequently, there is a high demand for dermocosmetics that do not provoke such reactions and are suitable for use in rosacea. The present guideline of the Society for Dermopharmacy describes the requirements that dermocosmetics for use in rosacea should meet...
March 29, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29593494/antiepileptogenic-effect-of-subchronic-palmitoylethanolamide-treatment-in-a-mouse-model-of-acute-epilepsy
#14
Julia M Post, Sebastian Loch, Raissa Lerner, Floortje Remmers, Ermelinda Lomazzo, Beat Lutz, Laura Bindila
Research on the antiepileptic effects of (endo-)cannabinoids has remarkably progressed in the years following the discovery of fundamental role of the endocannabinoid (eCB) system in controlling neural excitability. Moreover, an increasing number of well-documented cases of epilepsy patients exhibiting multi-drug resistance report beneficial effects of cannabis use. Pre-clinical and clinical research has increasingly focused on the antiepileptic effectiveness of exogenous administration of cannabinoids and/or pharmacologically induced increase of eCBs such as anandamide (also known as arachidonoylethanolamide [AEA])...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29587186/role-of-%C3%AE-2-3-specific-gaba-a-receptor-isoforms-in-the-development-of-hippocampus-kindling-epileptogenesis
#15
Doodipala Samba Reddy, Ryan F Yoshimura, Gunasekaran Ramanathan, Chase Carver, Timothy B Johnstone, Derk J Hogenkamp, Kelvin W Gee
OBJECTIVE: Subunit-specific positive allosteric modulators (PAMs) of gamma-aminobutyric acid-A (GABA-A) receptors are commonly used to uncover the role of GABA-A receptor isoforms in brain function. Recently, we have designed novel PAMs selective for β2/3 -subunit containing GABA-A receptors (β2/3 -selective PAMs) that are nonbenzodiazepine site-mediated and do not show an α-subunit isoform selectivity, yet exhibit anxiolytic efficacy with reduced potential for sedation, cognitive impairment, and tolerance...
March 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29577374/comparison-of-behavioral-neuroprotective-and-proinflammatory-cytokine-modulating-effects-exercised-by-cis-ec-and-cis-ec-stereoisomers-in-a-ptz-induced-kindling-test-in-mice
#16
Paula Regina Rodrigues Salgado, Diogo Vilar da Fonsêca, Cynthia Germoglio Farias de Melo, Fagner Carvalho Leite, Adriano Francisco Alves, Paula Benvindo Ferreira, Márcia Regina Piuvezam, Damião Pergentino de Sousa, Reinaldo Nóbrega de Almeida
Epoxy-carvone (EC) has chiral centers that allow generation of stereoisomers, including (+)-cis-EC and (-)-cis-EC, whose effects in the kindling tests have never been studied. Accordingly, this study aims to comparatively investigate the effect of stereoisomers (+)-cis-epoxy-carvone and (-)-cis-epoxy-carvone on behavioral changes measured in scores, in the levels of cytokines (IL-1β, IL-6 and TNFα) and neuronal protection in the face of continuous treatment with pentylenetetrazol. Swiss mice were divided into 5 groups (n = 10), receiving vehicle, (+) - cis-EC, (-) - cis-EC (both at the dose of 30 mg / kg) and diazepam (4 mg/kg)...
March 25, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29568187/anticonvulsant-and-antioxidant-effects-of-musa-sapientum-stem-extract-on-acute-and-chronic-experimental-models-of-epilepsy
#17
Aditya J Reddy, Ashok Kumar Dubey, Shailendra S Handu, Prashant Sharma, Pramod K Mediratta, Qazi Mushtaq Ahmed, Seema Jain
Background: Musa sapientum (banana) plant extract has been shown to possess antioxidant activity in previous studies. Neuronal injury resulting from oxidative stress is an important factor involved in pathogenesis of epilepsy. Objective: The present study aimed to evaluate the anticonvulsant activity of M. sapientum stem extract (MSSE) in acute and chronic experimental models in mice and its effects on various markers of oxidative stress in the brain of pentylenetetrazole (PTZ)-kindled animals...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29566716/overexpression-of-zinc-%C3%AE-2-glycoprotein-suppressed-seizures-and-seizure-related-neuroflammation-in-pentylenetetrazol-kindled-rats
#18
Ying Liu, Teng Wang, Xi Liu, Yuetao Wen, Tao Xu, Xinyuan Yu, Xin Wei, Xueying Ding, Lijuan Mo, Maojia Yin, Xinjie Tan, Lifen Chen
BACKGROUND: Zinc-α2-glycoprotein (ZAG) is a 42-kDa protein reported as an anti-inflammatory adipocytokine. Evidences from clinical and experimental studies revealed that brain inflammation plays important roles in epileptogenesis and seizure. Interestingly, closely relationship between ZAG and many important inflammatory mediators has been proven. Our previous study identified ZAG in neurons and found that ZAG is decreased in epilepsy and interacts with TGFβ and ERK. This study aimed to investigate the role of ZAG in seizure and explore its effect on seizure-related neuroinflammation...
March 22, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29546592/rna-polymerase-1-is-transiently-regulated-by-seizures-and-plays-a-role-in-a-pharmacological-kindling-model-of-epilepsy
#19
Aruna Vashishta, Lukasz P Slomnicki, Maciej Pietrzak, Scott C Smith, Murali Kolikonda, Shivani P Naik, Rosanna Parlato, Michal Hetman
Ribosome biogenesis, including the RNA polymerase 1 (Pol1)-mediated transcription of rRNA, is regulated by the pro-epileptogenic mTOR pathway. Therefore, hippocampal Pol1 activity was examined in mouse models of epilepsy including kainic acid- and pilocarpine-induced status epilepticus (SE) as well as a single seizure in response to pentylenetetrazole (PTZ). Elevated 47S pre-rRNA levels were present acutely after induction of SE suggesting activation of Pol1. Conversely, after a single seizure, 47S pre-rRNA was transiently downregulated with increased levels of unprocessed 18S rRNA precursors in the cornu Ammonis (CA) region...
March 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29546295/indispensable-amino-acid-deficient-diets-induce-seizures-in-ketogenic-diet-fed-rodents-demonstrating-a-role-for-amino-acid-balance-in-dietary-treatments-for-epilepsy
#20
Dorothy W Gietzen, Sarah H Lindström, James W Sharp, Pok Swee Teh, Michael J Donovan
Background: Low protein amounts are used in ketogenic diets (KDs), where an essential (indispensable) amino acid (IAA) can become limiting. Because the chemically sensitive, seizurogenic, anterior piriform cortex (APC) is excited by IAA limitation, an imbalanced KD could exacerbate seizure activity. Objective: We questioned whether dietary IAA depletion worsens seizure activity in rodents fed KDs. Methods: In a series of 6 trials, male rats or gerbils of both sexes (6-8/group) were given either control diets (CDs) appropriate for each trial, a KD, or a threonine-devoid (ThrDev) diet for ≥7 d, and tested for seizures using various stimuli...
March 1, 2018: Journal of Nutrition
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