Yi Zheng, Xiaomin Wang, Qiang Ji, Aizhong Fang, Lairong Song, Xiaoying Xu, Yi Lin, Yichen Peng, Jianyu Yu, Lei Xie, Feng Chen, Xiaojie Li, Sipeng Zhu, Botao Zhang, Lili Zhou, Chunna Yu, YaLi Wang, Liang Wang, Han Hu, Ziyi Zhang, Binlei Liu, Zhen Wu, Wenbin Li
Glioblastoma (GBM), the deadliest central nervous system cancer, presents a poor prognosis and scant therapeutic options. Our research spotlights OH2, an oncolytic viral therapy derived from herpes simplex virus 2 (HSV-2), which demonstrates substantial antitumor activity and favorable tolerance in GBM. The extraordinary efficacy of OH2 emanates from its unique mechanisms: it selectively targets tumor cells replication, powerfully induces cytotoxic DNA damage stress, and kindles anti-tumor immune responses...
March 25, 2024: Cancer Letters