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https://www.readbyqxmd.com/read/29432341/rare-case-of-intratracheal-metastasis-detected-on-68ga-prostate-specific-membrane-antigen-pet-ct-scan-in-a-case-of-thyroglobulin-elevated-negative-iodine-scan-syndrome
#1
Arun Sasikumar, Ajith Joy, M R A Pillai, Karuna Elza Oommen, R Jayakumar
A 64-year-old woman underwent completion thyroidectomy with upper tracheal ring resection and right-sided neck dissection for papillary carcinoma of the thyroid infiltrating the trachea and was given I radioiodine treatment. Three years later, she presented with hemoptysis. On evaluation, she had increased serum thyroglobulin and negative iodine scan (TENIS). F-FDG PET/CT scan did not identify any site of disease. One year later, Ga-PSMA scan done revealed a moderate focal tracer-avid intratracheal soft tissue; biopsy revealed it to be metastatic papillary carcinoma of the thyroid...
February 9, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29425566/functional-outcome-in-contemporary-children-with-total-cavopulmonary-connection-health-related-physical-fitness-exercise-capacity-and-health-related-quality-of-life
#2
Julia Hock, Barbara Reiner, Rhoia C Neidenbach, Renate Oberhoffer, Alfred Hager, Peter Ewert, Jan Müller
OBJECTIVE: Children and adolescents with an univentricular heart after total cavopulmonary connection (TCPC) have functional impairments. This study assesses health-related physical fitness (HRPF) and exercise capacity, as well as their relation to health-related quality of life (HRQoL) in patients with an univentricular heart after total-pulmonary connection (TCPC). PATIENTS AND METHODS: Between July 2014 and October 2016 a total of 78 children and adolescents with TCPC (12...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29415475/low-pass-filter-for-hv-partial-discharge-testing
#3
Vladimir Kindl, Bohumil Skala, Roman Pechanek, Vaclav Kus, Jaroslav Hornak
The most common cause of high voltage electric machine malfunction is an electrical failure of the insulation system due to extreme partial discharges activity. The paper discusses the methodology for the construction of a low-pass high voltage filter for partial discharge measurement. It focuses mainly on the shape optimization, using an analytical approach with subsequent verification using the finite element method. The experimental verification is given together with important conclusions.
February 6, 2018: Sensors
https://www.readbyqxmd.com/read/29377096/delayed-myelination-and-neurodevelopment-in-male-seizure-prone-versus-seizure-resistant-rats
#4
Pragati Sharma, Kim L Powell, Mary E Wlodek, Terence J O'Brien, Krista L Gilby
OBJECTIVE: Aberrant myelination and developmental delay have been reported in epilepsy. However, it is unclear whether these are linked to intrinsic mechanisms that support a predisposition toward seizures and the development of epilepsy. Thus, we compared rates of myelination and neurodevelopment in male rats selectively bred for enhanced susceptibility to kindling epileptogenesis (FAST) with male rats bred for resistance (SLOW). METHODS: Myelin-specific gene expression was compared in the brainstem, cerebellum, and cerebral hemisphere of FAST and SLOW rats on postnatal days (PNDs) 5, 11, 17, 23, and 90 to determine strain-specific myelination rates...
January 28, 2018: Epilepsia
https://www.readbyqxmd.com/read/29361417/a-review-of-resources-and-methodologies-available-for-teaching-and-assessing-patient-related-communication-skills-in-radiology
#5
David Sarkany, Carolynn M DeBenedectis, Stephen D Brown
ACGME expectations for radiology trainees' proficiencies in communication skills pose a challenge to program directors who wish to develop curricula addressing these competencies. Numerous educational resources and pedagogical approaches have emerged to address such competencies specifically for radiology, but have yet to be systematically catalogued. In this paper, we review and compile these resources into a toolkit that will help residencies develop curricula around patient-centered communication. We describe numerous web-based resources and published models that have incorporated innovative, contemporary pedagogical techniques...
January 17, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29360159/potent-and-selective-pharmacodynamic-synergy-between-the-metabotropic-glutamate-receptor-subtype-2-positive-allosteric-modulator-jnj-46356479-and-levetiracetam-in-the-mouse-6-hz-44-ma-model
#6
Cameron S Metcalf, Brian D Klein, Misty D Smith, Marc Ceusters, Hilde Lavreysen, Stefan Pype, Nancy Van Osselaer, Roy Twyman, H Steve White
OBJECTIVE: We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2 ) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes isobolographic analysis to evaluate the combined administration of JNJ-46356479, a selective and potent mGlu2 PAM, with LEV as well as sodium valproate (VPA) and lamotrigine (LTG). METHODS: The anticonvulsant efficacy of JNJ-46356479 was evaluated in the 6-Hz model of psychomotor seizures in mice...
January 23, 2018: Epilepsia
https://www.readbyqxmd.com/read/29357320/ginsenoside-rb1-protects-the-brain-from-damage-induced-by-epileptic-seizure-via-nrf2-are-signaling
#7
Yunbo Shi, Wang Miao, Junfang Teng, Lingli Zhang
BACKGROUND/AIMS: Ginsenoside Rb1 (Rb1) has been reported to have varieties of neuroprotective effects. This study aimed to evaluate the effects of Rb1 on pentylenetetrazol (PTZ)-induced rat brain injury and Mg2+ free-induced neuron injury and analyzed the detailed molecular mechanisms in vivo and in vitro. METHODS: Seizure duration and latency were measured in epilepsy kindled rat. The cognitive impairment was assessed by Morris water maze (MWM) test. Oxidative stress parameters, malondialdehyde (MDA) and glutathione (GSH) were measured by the 2-thiobarbituric acid methods and the DTNB-GSSG reductase recycling methods...
January 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29350682/conditional-replication-of-oncolytic-viruses-based-on-detection-of-oncogenic-mrna
#8
REVIEW
M Renteln
Recently, split intein-based detection sensors for RNA have been developed that can target custom sequences in a modular fashion. If multi-region, multi-sample sequencing were to be applied to a patient's cancer, truncal (i.e., earliest-occurring) mutations could be identified and could serve as targets for these sense-and-respond modules. The next step would be to utilize an effective vector for treatment. A hyper-virulent herpes simplex virus could possibly serve as this vector, with concurrent immunosuppression to allow for unhindered infection of the tumor regions...
January 19, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29350575/the-neural-substrates-of-improved-phonological-processing-following-successful-treatment-in-a-case-of-phonological-alexia-and-agraphia
#9
Andrew T DeMarco, Stephen M Wilson, Kindle Rising, Steven Z Rapcsak, Pélagie M Beeson
Phonological deficits are common in aphasia after left-hemisphere stroke, and can have significant functional consequences for spoken and written language. While many individuals improve through treatment, the neural substrates supporting improvements are poorly understood. We measured brain activation during pseudoword reading in an individual through two treatment phases. Improvements were associated with greater activation in residual left dorsal language regions and bilateral regions supporting attention and effort...
January 19, 2018: Neurocase
https://www.readbyqxmd.com/read/29346088/intense-olfactory-stimulation-blocks-seizures-in-an-experimental-model-of-epilepsy
#10
Polianna Delfino-Pereira, Poliana Bertti-Dutra, Eduardo Henrique de Lima Umeoka, José Antônio Cortes de Oliveira, Victor Rodrigues Santos, Artur Fernandes, Simone Saldanha Marroni, Flávio Del Vecchio, Norberto Garcia-Cairasco
There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation. Similar findings were described in animal models of epilepsy, such as the electrical kindling of amygdala, where olfactory stimulation with toluene (TOL) suppressed seizures in most rats, even when the stimuli were 20% above the threshold to evoke seizures in already kindled animals. The Wistar Audiogenic Rat (WAR) strain is a model of tonic-clonic seizures induced by acute acoustic stimulation, although it also expresses limbic seizures when repeated acoustic stimulation occurs - a process known as audiogenic kindling (AK)...
January 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29338667/docosahexaenoic-acid-prevents-resistance-to-antiepileptic-drugs-in-two-animal-models-of-drug-resistant-epilepsy
#11
Melika Moezifar, Mohammad Sayyah, Morteza Zendehdel, Hakimeh Gavzan
OBJECTIVES: One-third of epileptic patients are resistant to antiepileptic drugs. Few clinical studies with small sample size indicate that polyunsaturated fatty acids could control drug-resistant epilepsy. We examined the efficacy of acute and chronic administration of docosahexaenoic acid (DHA) in two animal models of drug-resistant epilepsies, i.e. 6-Hz psychomotor seizures in mice and lamotrigine (LTG)-resistant kindled rats. METHODS: Mice received a single injection of DHA (300 µM, i...
January 16, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29317669/selective-targeting-of-scn8a-prevents-seizure-development-in-a-mouse-model-of-mesial-temporal-lobe-epilepsy
#12
Jennifer C Wong, Christopher D Makinson, Tyra Lamar, Qi Cheng, Jeffrey C Wingard, Ernest F Terwilliger, Andrew Escayg
We previously found that genetic mutants with reduced expression or activity of Scn8a are resistant to induced seizures and that co-segregation of a mutant Scn8a allele can increase survival and seizure resistance of Scn1a mutant mice. In contrast, Scn8a expression is increased in the hippocampus following status epilepticus and amygdala kindling. These findings point to Scn8a as a promising therapeutic target for epilepsy and raise the possibility that aberrant overexpression of Scn8a in limbic structures may contribute to some epilepsies, including temporal lobe epilepsy...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29309958/no-differences-in-manic-like-behaviors-between-voluntary-ethanol-and-water-drinking-in-lateral-hypothalamic-kindled-lhk-alcohol-preferring-rats
#13
Noha Abdel Gawad, Khalid Mohamed, Doo-Sup Choi, Osama A Abulseoud
This study investigates phenotypic differences of manic-like behaviors during voluntary ethanol (vs. water) intake in alcohol preferring (P) rats, using the lateral hypothalamus kindled (LHK) rat mania model. Alcohol preferring (P) rats exhibited classic manic-like behaviors during kindling and the post-kindling intervals in all coded behaviors (p < 0.0001), lending further validity to the lateral hypothalamus kindled rat as a useful model to study mania. However, there was no significant phenotypic difference between alcohol and water drinking alcohol preferring (P) rats...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29306758/altered-expression-of-gaba-a-receptor-subunits-in-the-hippocampus-of-ptz-kindled-rats
#14
Janusz Szyndler, Piotr Maciejak, Karolina Kołosowska, Natalia Chmielewska, Anna Skórzewska, Patrycja Daszczuk, Adam Płaźnik
BACKGROUND: Changes in the expression of the GABA-A receptor subunits involved in phasic and tonic inhibition have been studied in a wide spectrum of animal models of epilepsy. However, there is no exhaustive data regarding the pentylenetetrazole (PTZ) kindling model of epilepsy. METHODS: The aim of our study was to analyse the hippocampal changes in the expression of GABA-A receptor subunits involved in phasic (α1, γ2) or tonic (α4 and δ) inhibition in rats subjected to the PTZ kindling using immunohistochemistry method as well as in animals subjected to a single injection of a subconvulsive (30 mg/kg) or convulsive (55 mg/kg) dose of PTZ...
July 16, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29298550/maximising-recovery-from-aphasia-with-central-and-peripheral-agraphia-the-benefit-of-sequential-treatments
#15
Pélagie M Beeson, Chelsea Bayley, Christine Shultz, Kindle Rising
Maximal recovery from acquired language impairment may require progression from one behavioural treatment protocol to the next in order to build upon residual and relearned cognitive-linguistic and sensory-motor processes. We present a five-stage treatment sequence that was initiated at one year post stroke in a woman with acquired impairments of spoken and written language. As is typical of individuals with left perisylvian damage, she demonstrated marked impairment of phonological retrieval and sublexical phonology, but she also faced additional challenges due to impaired letter shape knowledge and visual attention...
January 3, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29287009/adherence-to-the-gluten-free-diet-and-health-related-quality-of-life-in-an-ethnically-diverse-pediatric-population-with-celiac-disease
#16
Diana Mager, Margaret Marcon, Herbert Brill, Amanda Liu, Kristin Radmanovich, Heather Mileski, Roseann Nasser, Abeer Alzaben, Matthew W Carroll, Jason Yap, Rabin Persad, Justine M Turner
OBJECTIVES: Celiac disease (CD) is an autoimmune disease that requires life-long adherence to a gluten-free diet (GFD). Adherence to the GFD in childhood may be poor and adversely influence health related quality of life (HRQOL). The study purpose was to determine socio-demographic and socio-economic factors influencing adherence to the GFD and HRQOL in a multi-ethnic cohort of youth with CD. METHODS: A multi-site (Edmonton, Hamilton, Toronto) study examining child-parent HRQOL in youth with CD (n=243) and /or mild gastrointestinal complaints (GI-CON; n = 148) was conducted...
January 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29246138/the-immunomodulatory-activities-of-licorice-polysaccharides-glycyrrhiza-uralensis-fisch-in-ct-26-tumor-bearing-mice
#17
Peter Amwoga Ayeka, YuHong Bian, Peter Mwitari Githaiga, Ying Zhao
BACKGROUND: The increasing use of complementary and alternative medicine (CAM) has kindled the need for scientific evaluation of the mechanism of action of CAMs. Although, licorice, a common ingredient in many Traditional Chinese medicine (TCM) has attracted great attention for its antitumor and immunomodulatory activities, the mechanism of action of its polysaccharides is still unclear. Here we report the immunomodulatory activity of licorice polysaccharides in vivo. METHODS: The differential anticancer activities of licorice polysaccharides by tumorigenesis and immunomodulation was evaluated in vivo...
December 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29237434/bidirectional-associations-between-psychosocial-well-being-and-adherence-to-healthy-dietary-guidelines-in-european-children-prospective-findings-from-the-idefics-study
#18
Louise Arvidsson, Gabriele Eiben, Monica Hunsberger, Ilse De Bourdeaudhuij, Denes Molnar, Hannah Jilani, Barbara Thumann, Toomas Veidebaum, Paola Russo, Michael Tornatitis, Alba M Santaliestra-Pasías, Valeria Pala, Lauren Lissner
BACKGROUND: In children the relationship between a healthy diet and psychosocial well-being has not been fully explored and the existing evidence is inconsistent. This study investigates the chronology of the association between children's adherence to healthy dietary guidelines and their well-being, with special attention to the influence of weight status on the association. METHODS: Seven thousand six hundred seventy five children 2 to 9 years old from the eight-country cohort study IDEFICS were investigated...
December 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29234274/neuronal-nitric-oxide-synthase-contributes-to-ptz-kindling-epilepsy-induced-hippocampal-endoplasmic-reticulum-stress-and-oxidative-damage
#19
Xinjian Zhu, Jingde Dong, Bing Han, Rongrong Huang, Aifeng Zhang, Zhengrong Xia, Huanhuan Chang, Jie Chao, Honghong Yao
Epilepsy is one of the most common chronic neurological disorders which provoke progressive neuronal degeneration. Endoplasmic reticulum (ER) stress has recently been recognized as pivotal etiological factors contributing to epilepsy-induced neuronal damage. However, the specific contribution of epilepsy made to ER stress remains largely elusive. Here we use pentylenetetrazole (PTZ) kindling, a chronic epilepsy model, to identify neuronal nitric oxide synthase (nNOS) as a signaling molecule triggering PTZ kindling epilepsy-induced ER stress and oxidative damage...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29227797/anticonvulsant-effects-of-acetaminophen-in-mice-comparison-with-the-effects-of-nonsteroidal-anti-inflammatory-drugs
#20
Katsuya Suemaru, Misato Yoshikawa, Akihiro Tanaka, Hiroaki Araki, Hiroaki Aso, Masahiko Watanabe
OBJECTIVE: The appropriate use of analgesic drugs based on their degree of analgesia and adverse effects is important for pain management. Although it has been reported that AM404, a metabolite of acetaminophen, has anticonvulsant effects in several animal seizure models, little is known about the relation between acetaminophen and seizures. We therefore investigated the effects of acetaminophen on seizure susceptibility in several mouse seizure and epilepsy models and compared the effects with those of nonsteroidal anti-inflammatory drugs (NSAIDs)...
December 5, 2017: Epilepsy Research
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