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https://www.readbyqxmd.com/read/28078241/the-effect-of-zataria-multiflora-boiss-hydroalcoholic-extract-and-fractions-in-pentylenetetrazole-induced-kindling-in-mice
#1
Ali Shamsizadeh, Farangis Fatehi, Fatemeh Arab Baniasad, Fatemeh Ayoobi, Mohammad Ebrahim Rezvani, Ali Roohbakhsh
OBJECTIVE: At present, there are many antiepileptic drugs with a wide range of side effects on the human body. It was assumed that Zataria multiflora Boiss (Z. multiflora) with sedative, anti-spasmodic and anti-inflammatory activity may be effective in the treatment of epilepsy. The aim of the present study was to elucidate the effect of Z. multiflora hydroalcoholic extract and its fraction extracts on pentylenetetrazole (PTZ)-induced chemical kindling. MATERIALS AND METHODS: In this experimental study, eight separate groups of male albino mice were used...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28065794/adjuvant-quercetin-therapy-for-combined-treatment-of-epilepsy-and-comorbid-depression
#2
Tanveer Singh, Taranjot Kaur, Rajesh Kumar Goel
Epilepsy is one of the major neurological disorders frequently associated with psychiatric disorders such as depression. The predisposition of tryptophan metabolism towards kynurenine pathway has been reported as one of the plausible reasons for association of depression in epilepsy. Hence, this study was envisaged to evaluate the dose dependent inhibition of indoleamine 2,3-dioxygenase (IDO) enzyme employing quercetin (screened employing in vitro method) with levetiracetam for combined management of epilepsy and comorbid depression...
January 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28060522/aspirin-and-or-omega-3-polyunsaturated-fatty-acids-protect-against-corticohippocampal-neurodegeneration-and-downregulate-lipoxin-a4-production-and-formyl-peptide-receptor-like-1-expression-in-pentylenetetrazole-kindled-rats
#3
Basma A Abd-Elghafour, Norhan M El-Sayed, Amal A M Ahmed, Sawsan A Zaitone, Yasser M Moustafa
There is evidence for a relationship between inflammation and seizures because epilepsy can be caused by or result in inflammation. This study aimed to investigate the effect of aspirin and (or) omega-3 polyunsaturated fatty acids (PUFAs) on seizure activity and neurodegeneration in pentylenetetrazole (PTZ)-kindled rats focusing on their effect on corticohippocampal production of lipoxin A4 (LXA4) and expression of formyl peptide receptor-like 1 (FPRL1) receptors. Male rats were injected with PTZ (35 mg/kg, i...
November 10, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28042539/effects-of-low-frequency-stimulation-on-spontaneous-inhibitory-and-excitatory-post-synaptic-currents-in-hippocampal-ca1-pyramidal-cells-of-kindled-rats
#4
Samireh Ghafouri, Yaghoub Fathollahi, Saeed Semnanian, Amir Shojaei, Javad Mirnajafi-Zadeh
OBJECTIVE: Low-frequency stimulation (LFS) exerts suppressive effects in kindled animals. It is believed that overstimulated glutamatergic and decreased GABAergic transmission have long been associated with seizure activity. In this study, we investigated the effect of electrical LFS on different parameters of spontaneous excitatory and inhibitory post-synaptic currents (sEPSCs and sIPSCs) in hippocampal CA1 pyramidal cells in kindled animals. MATERIALS AND METHODS: In this experimental study, rats were kindled by electrical stimulation of the hippocampal CA1 area in a semi-rapid manner (12 stimulations/day)...
2017: Cell Journal
https://www.readbyqxmd.com/read/28038337/common-data-elements-and-data-management-remedy-to-cure-underpowered-preclinical-studies
#5
Niina Lapinlampi, Esbjörn Melin, Eleonora Aronica, Jens P Bankstahl, Albert Becker, Cristophe Bernard, Jan A Gorter, Olli Gröhn, Anu Lipsanen, Katarzyna Lukasiuk, Wolfgang Löscher, Jussi Paananen, Teresa Ravizza, Paolo Roncon, Michele Simonato, Annamaria Vezzani, Merab Kokaia, Asla Pitkänen
Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data collection and analysis, and has been used for a long time in clinical studies testing anti-seizure drugs. EPITARGET is a European Union FP7-funded research consortium composed of 18 partners from 9 countries. Its main research objective is to identify biomarkers and develop treatments for epileptogenesis...
November 22, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28012162/evidence-for-a-differential-interaction-of-brivaracetam-and-levetiracetam-with-the-synaptic-vesicle-2a-protein
#6
Martyn D Wood, Michel Gillard
OBJECTIVE: Brivaracetam (BRV) and levetiracetam (LEV) are effective antiepileptic drugs that bind selectively to the synaptic vesicle 2A (SV2A) protein. However, BRV differs from LEV in that it exhibits more potent and complete seizure suppression in animal models including in amygdala-kindled mice, where BRV afforded nearly complete seizure suppression. This raises the possibility that aside from potency differences, BRV and LEV may interact differently with the SV2A protein, which is not apparent in radioligand-binding competition studies...
December 24, 2016: Epilepsia
https://www.readbyqxmd.com/read/27998342/c-f-goodey-learning-disability-and-inclusion-phobia-past-present-future-oxon-and-new-york-routledge-2016-pp-viii-178-%C3%A2-79-00-hardback-%C3%A2-25-49-kindle-isbn-978-0-415-82200-8-hbk-and-978-0-203-55665-8-ebk
#7
https://www.readbyqxmd.com/read/27995445/promoting-virtue-or-punishing-fraud-mapping-contrasts-in-the-language-of-scientific-integrity
#8
S P J M Horbach, W Halffman
Even though integrity is widely considered to be an essential aspect of research, there is an ongoing debate on what actually constitutes research integrity. The understanding of integrity ranges from the minimal, only considering falsification, fabrication and plagiarism, to the maximum, blending into science ethics. Underneath these obvious contrasts, there are more subtle differences that are not as immediately evident. The debate about integrity is usually presented as a single, universal discussion, with shared concerns for researchers, policymakers and 'the public'...
December 19, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27993742/immediate-titanium-mesh-implantation-for-patients-with-postcraniotomy-neurosurgical-site-infections-a-safe-and-esthetic-alternative-procedure
#9
Gregory Ehrlich, Stefanie Kindling, Holger Wenz, Daniel Hänggi, Dirk Michael Schulte, Peter Schmiedek, Marcel Seiz-Rosenhagen
BACKGROUND: Surgical site infection (SSI) is one of the main complications after craniotomy. The incidence is up to 11% in the literature. The established procedure is debridement, removal of the bone flap and delayed cranioplasty. Delayed cranioplasty has several disadvantages. A promising approach is the immediate titanium mesh implantation at the time of wound revision. We want to report our experience with this technique with regard to outcome measured by reinfection rates and patient satisfaction...
December 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27992891/negative-experiences-in-childhood-and-the-development-and-course-of-bipolar-disorder
#10
REVIEW
Paulina Jaworska-Andryszewska, Janusz Rybakowski
The aim of this paper is to review the effects of negative childhood experiences on the development and course of bipolar disorder (BD) and to discuss the involved mechanisms. The negative childhood experiences that may play a role in BD are critical or traumatic events including all kinds of abuse, loss of a parent or parents resulting from death, suicide, separation, divorce or prolonged separation. Previous studies indicate that in BD patients negative childhood events are more frequent than in control group...
October 31, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27966317/health-related-quality-of-life-of-pediatric-renal-transplant-recipientsand-their-parents-the-role-of-associated-factors-and-clinical-counseling
#11
Bahar Büyükkaragöz, Necla Buyan, Nahide Doğrucan, Bülent Çelik
BACKGROUND/AIM: This study evaluates the health-related quality of life (HRQoL) of pediatric renal transplant recipients and their parents and investigates the effects of clinical, socioeconomic, and psychological factors as well as continuous counseling on the HRQoL. MATERIALS AND METHODS: Patients aged 8-17 years (mean: 14.9 ± 2.9) were enrolled. Clinical and demographic data were noted. The Beck Depression Inventory (BDI), Rosenberg Self-Esteem Scale (RSES), and Turkish version of the Kinder Lebensqualität Fragebogen (KINDL) questionnaire for children and the BDI, RSES, parent-proxy version of KINDL, and Short-Form 36 (SF-36) for parents were applied (step 1)...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27955671/pro-epileptogenic-effects-of-viral-like-inflammation-in-both-mature-and-immature-brains
#12
Nina Dupuis, Andrey Mazarati, Béatrice Desnous, Vibol Chhor, Bobbi Fleiss, Tifenn Le Charpentier, Sophie Lebon, Zsolt Csaba, Pierre Gressens, Pascal Dournaud, Stéphane Auvin
BACKGROUND: Infectious encephalitides are most often associated with acute seizures during the infection period and are risk factors for the development of epilepsy at later times. Mechanisms of viral encephalitis-induced epileptogenesis are poorly understood. Here, we evaluated the contribution of viral encephalitis-associated inflammation to ictogenesis and epileptogenesis using a rapid kindling protocol in rats. In addition, we examined whether minocycline can improve outcomes of viral-like brain inflammation...
December 12, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27938477/effects-of-human-es-derived-neural-stem-cell-transplantation-and-kindling-in-a-rat-model-of-traumatic-brain-injury
#13
Stefania Beretta, Kelly Cunningham, Daniel Haus, Eric Gold, Harvey Perez, Luci López-Velázquez, Brian Cummings
Traumatic Brain Injury (TBI) is one of the leading causes of death and disability in the population worldwide, with a broad spectrum of symptoms and disabilities. Post-traumatic hyperexcitability is one of the most common neurological disorders that affect people after a head injury. A reliable animal model of post-traumatic hyperexcitability induced by TBI which allows one to test effective treatment strategies has yet to be developed. To address these issues, in the present study, we tested human ES-derived neural stem cell transplantation in an animal model of post-traumatic hyperexcitability in which the brain injury was produced in one hemisphere of immunodeficient athymic nude (ATN) rats by controlled cortical impact (CCI) and spontaneous seizures were produced by repeated electrical stimulation (kindling) in the contralateral hemisphere...
22, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27927066/assessment-of-luteolin-isolated-from-eclipta-alba-leaves-in-animal-models-of-epilepsy
#14
Rufi Tambe, Aditi Patil, Pankaj Jain, Jayant Sancheti, Gauresh Somani, Sadhana Sathaye
CONTEXT: Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. OBJECTIVE: The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically induced acute and chronic models in mice. MATERIALS AND METHODS: The methanol extract (16.85% w/w) of E. alba leaves was subjected to fractionation for isolation of luteolin...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27923157/adjuvant-neuronal-nitric-oxide-synthase-inhibition-for-combined-treatment-of-epilepsy-and-comorbid-depression
#15
Tanveer Singh, Rajesh Kumar Goel
BACKGROUND: Elevated nitric oxide (NO) levels in the brain have been apparently associated with depression in kindled animals. Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression. METHODS: Pentylenetetrazole kindled animals associated with depression were treated with vehicle, valproate (300mg/kg/day ip), valproate with 7-NI (10mg/kg; 20mg/kg; 40mg/kg)/day ip and 7-NI (40mg/kg/day ip) for 15days...
February 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27905510/remarkable-alterations-of-nav1-6-in-reactive-astrogliosis-during-epileptogenesis
#16
Hongyan Zhu, Yuxiao Zhao, Hao Wu, Nan Jiang, Ziyi Wang, Weide Lin, Jiahui Jin, Yonghua Ji
Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical induction of status epilepticus (SE). To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we examined the expression of Nav1.6 at protein and mRNA levels in two distinct animal models of temporal lobe epilepsy (TLE) including a post-SE model induced by kainic acid (KA) intrahippocampal injection and a kindling model evoked by pentylenetetrazole (PTZ)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905227/a-practical-guide-to-forensic-nursing-amar-angela-f-and-sekula-l-kathleen-a-practical-guide-to-forensic-nursing-392pp-%C3%A2-38-85-sigma-theta-tau-international-kindle-edition-9781940446349-1940446341-formula-see-text
#17
(no author information available yet)
This fascinating publication describes in depth the roles and responsibilities of forensic nurses in the US, who are often involved in the scientific investigation of violent and sexual crimes. However, these duties differ from those of nurses in forensic or secure settings in the UK, who work primarily with offenders who have mental health problems and who are in hospital, prison or police cells.
December 1, 2016: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/27900177/high-intensity-interval-training-to-improve-fitness-in-children-with-cerebral-palsy
#18
Reidun Lauglo, Torstein Vik, Torarin Lamvik, Dorthe Stensvold, Ane-Kristine Finbråten, Trine Moholdt
AIM: To evaluate effects of high-intensity interval training (HIT) on aerobic exercise capacity, quality of life, and body composition in children with cerebral palsy (CP). METHODS: This was a baseline control trial. Children with CP, Gross Motor Function Classification System (GMFCS) levels I-IV, and age 10-17 years were included. The primary outcome, peak, and submaximum oxygen uptake (VO2peak, VO2submax) were measured at enrolment to the study (T0), after a pretraining period (T1), and after HIT (T2)...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898941/influence-of-feeding-strategy-and-diet-for-reproductive-rabbit-does-on-intake-performances-and-health-of-young-and-females-before-and-after-weaning
#19
T Read, S Combes, T Gidenne, N Destombes, K Bébin, E Balmisse, L Fortun-Lamothe
This study aimed to determine the influences of feeding strategy and diet for reproductive females on feed intake, BW, reproductive performances, and milk composition and their effects on kit performances from birth (d 0) to 70 d of age (d 70). A total of 133 does followed for 3 reproductive cycles and their offspring, 2,322 kits from 236 litters, were divided into 3 experimental groups that differed only by the diet offered to the doe. Three experimental diets were used: a reproduction (Repro) diet (11.01 MJ DE/kg, 24...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27891086/circuits-regulating-pleasure-and-happiness-mechanisms-of-depression
#20
Anton J M Loonen, Svetlana A Ivanova
According to our model of the regulation of appetitive-searching vs. distress-avoiding behaviors, the motivation to display these essential conducts is regulated by two parallel cortico-striato-thalamo-cortical, re-entry circuits, including the core and the shell parts of the nucleus accumbens, respectively. An entire series of basal ganglia, running from the caudate nucleus on one side, to the centromedial amygdala on the other side, controls the intensity of these reward-seeking and misery-fleeing behaviors by stimulating the activity of the (pre)frontal and limbic cortices...
2016: Frontiers in Human Neuroscience
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