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Kindling

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https://www.readbyqxmd.com/read/28635087/eat-to-cheat-dementia-n-hobbins-self-published-book-hobart-2016-isbn-9780994344014-paperback-paperback-a-19-20-kindle-a-9-12
#1
Ralph Hampson, Yvonne Wells
No abstract text is available yet for this article.
June 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28632301/regulation-of-kindling-epileptogenesis-by-hippocampal-toll-like-receptors-2
#2
Jesús-Servando Medel-Matus, Ashley Reynolds, Don Shin, Raman Sankar, Andrey Mazarati
This study examined whether Toll-like receptors 2 (TLR2) contribute to rapid kindling epileptogenesis. A TLR2 agonist, lipoteichoic acid (LTA), LTA antibody (LTA-A), or normal saline (control) was administered daily over 3 consecutive days, unilaterally into ventral hippocampus of adult male Wistar rats. Thirty minutes after the last injection, the animals were subjected to a rapid kindling procedure. The ictogenesis was gauged by comparing afterdischarge threshold (ADT) and afterdischarge duration (ADD) before the treatments, after the treatments prior to kindling, and 24 h after kindling...
June 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/28624414/corneal-kindled-c57bl-6-mice-exhibit-saturated-dentate-gyrus-long-term-potentiation-and-associated-memory-deficits-in-the-absence-of-overt-neuron-loss
#3
Gregory J Remigio, Jaycie L Loewen, Sage Heuston, Colin Helgeson, H Steve White, Karen S Wilcox, Peter J West
Memory deficits have a significant impact on the quality of life of patients with epilepsy and currently no effective treatments exist to mitigate this comorbidity. While these cognitive comorbidities can be associated with varying degrees of hippocampal cell death and hippocampal sclerosis, more subtle changes in hippocampal physiology independent of cell loss may underlie memory dysfunction in many epilepsy patients. Accordingly, animal models of epilepsy or epileptic processes exhibiting memory deficits in the absence of cell loss could facilitate novel therapy discovery...
June 15, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28623008/yucca-schidigera-can-promote-rabbit-growth-fecundity-affect-the-release-of-hormones-in-vivo-and-in-vitro-induce-pathological-changes-in-liver-and-reduce-ovarian-resistance-to-benzene
#4
Martina Földešiová, Andrej Baláži, Ľubica Chrastinová, Juraj Pivko, Jan Kotwica, Abdel Halim Harrath, Peter Chrenek, Alexander V Sirotkin
This study evaluated the effect of Yucca schidigera (YS) extract on the physiological, reproductive, and endocrine indexes of New Zealand White rabbit does. Six-week-old rabbit does were fed a standard diet (control group) or a diet enriched with 5 or 20g of Y powder extract per 100-kg feed mixture for 350days. The does were artificially inseminated after induction of superovulation. Weight gain; conception and kindling rate; viability of pups and mothers; histopathological state of liver and muscle; plasma levels of progesterone (P4), oxytocin (OT), and prostaglandin F (PGF); and the release of P4, insulin-like growth factor I (IGF-I), OT, and PGF by isolated ovarian fragments and their response to the addition of benzene were analyzed...
June 10, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28620683/modeling-production-functions-and-economic-weights-in-intensive-meat-production-of-guinea-pigs
#5
Mariam Pascual, Danny Julio Cruz, Agustín Blasco
A profit function for a typical commercial farm of intensive guinea pig production was designed. The simulated farm contained 86 cages with a ratio of 7:1 females/males, with continuous mating. Kits were weaned at 15 days of age and slaughtered for meat production at 90 days of age. The absolute (EW) and relative economic weights of the main traits were calculated. The highest EW were kits produced per kindling (US$25), kits weaned per kindling (US$22), kits born alive per kindling (US$20), and the number of kindlings per female and year (US$12)...
June 15, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28617378/-the-influence-of-growing-seizure-readiness-on-the-autonomic-regulation-of-the-heart
#6
M L Mamalyga, L M Mamalyga
AIM: To study the functional state of the heart in a progressive increase of seizure readiness (SR) due to pentylenetetrazole kindling. MATERIAL AND METHODS: The study was carried out on male rats of the Wistar line. Simultaneous telemetric monitoring of electrocardiogram and electroencephalogram on-line was used. Individual SR of animals in 7- and 27 day pentylenetetrazole kindling was determined. RESULTS: The decrease in the index of LF/HF after 7 days of kindling reflects a compensatory reaction of the autonomic nervous system...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28609692/childhood-maltreatment-psychopathology-and-well-being-the-mediator-role-of-global-self-esteem-attachment-difficulties-and-substance-use
#7
Hanne K Greger, Arne K Myhre, Christian A Klöckner, Thomas Jozefiak
Childhood maltreatment is known to be associated with a broad variety of psychopathology and deteriorated well-being in adolescent populations. In the present nationwide study, we aimed to explore global self-esteem, attachment difficulties and substance use as possible mediators of these associations in a high-risk adolescent population. We included 400 adolescents (aged 12-20 years) living in residential youth care in Norway (response rate 67%). The participants completed a semistructured psychiatric interview (Child and Adolescent Psychiatric Assessment (CAPA)), a study-specific questionnaire, a revised version of the Self-Perception Profile for Adolescents (SPPA) and the Questionnaire for Measuring Health-related Quality of Life in Children and Adolescents (KINDL-R)...
June 10, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28608235/ferulic-acid-supplementation-for-management-of-depression-in-epilepsy
#8
Tanveer Singh, Taranjot Kaur, Rajesh Kumar Goel
Neuroinflammation driven altered neurochemical milieu have been reported to play a significant role in pathogenesis of comorbid depression in epilepsy. Most of the antiepileptic drugs (AEDs) such as levetiracetam, taigabine, topiramate have not been reported any significant effect in alleviating neuroinflammation, which may explain their ineffectiveness in ameliorating depression associated with epilepsy. The supplementation of antidepressants (ADs) attracts various pharmacokinetic and pharmacodynamic interactions with AEDs and was considered unsafe in epilepsy...
June 12, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28602856/genetic-resistance-to-kindling-associated-with-alterations-in-circuit-function
#9
M Tansel Kendirli, Edward H Bertram
How a seizure spreads from a focal onset zone to other regions of the brain is not well understood, and animal studies suggest that there is a genetic influence. To understand how genetic factors may influence seizure spread, we examined whether the kindling resistance of WAG/Rij rats, which are slow to develop kindled motor seizures, is independent of the site of seizure induction and thus a global phenomenon, or whether it is circuit specific. We compared the kindling rates (number of stimulations to induce kindled motor seizures) of WAG/Rij rats to the rates of kindling in Sprague Dawley rats...
June 9, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28595035/n-methyl-d-aspartate-receptors-mediate-epilepsy-induced-axonal-impairment-and-tau-phosphorylation-via-activating-glycogen-synthase-kinase-3%C3%AE-and-cyclin-dependent-kinase-5
#10
Xi Liu, Shu Ou, Maojia Yin, Tao Xu, Teng Wang, Ying Liu, Xueying Ding, Xinyuan Yu, Jinxian Yuan, Hao Huang, Xiuhang Zhang, Xinjie Tan, Lifen Chen, Yangmei Chen
The mechanism of epilepsy-induced axonal impairment is poorly understood. N-methyl-D-aspartate receptors (NMDARs) play important roles in epilepsy and mediate structural and functional axonal impairment. GSK-3β and Cdk5 affect axons and are regulated by NMDARs, while their roles in epilepsy-induced axonal impairment are unclear. We demonstrated that axonal impairment is characterized by neurofilament heavy (NFH) reduction, amyloid precursor protein (APP) accumulation, and increased tau phosphorylation accompanied by a decrease of total tau in temporal lobe epilepsy (TLE) patients and pentylenetetrazol (PTZ)-kindled rats...
April 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28591482/hypothalamic-hamartoma-epileptogenesis-beyond-the-lesion
#11
Julia Scholly, Anke Maren Staack, Philippe Kahane, Didier Scavarda, Jean Régis, Edouard Hirsch, Fabrice Bartolomei
The discovery of intrinsic epileptogenicity of the hypothalamic hamartoma (HH) marked a new area in understanding the associated clinical syndrome, often manifesting as progressive epileptic encephalopathy. However, therapeutic procedures targeting the HH proved to be inefficient to cure seizures in up to 50% of cases, whereas in cases with partial improvement, the electroclinical patterns of persisting seizures suggest an involvement of distant cortical regions. The concept of kindling-like secondary epileptogenesis has been suggested as a possible underlying mechanism...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28589330/triple-combination-therapy-and-drug-cycling-tangential-strategies-for-countering-artemisinin-resistance
#12
REVIEW
Bhattacharjee Dipanjan, G Shivaprakash, O Balaji
PURPOSE OF REVIEW: This review attempts to understand the reasons for the successes and failures of the two novel strategies that have slowly begun to emerge as potential counters for anti-malarial drug resistance-"Triple Combination Therapy" and "Drug Cycling." RECENT FINDINGS: Recent reports have suggested that increasing the heterogeneity within the parasite's environment, both at an individual and the population level, may help raise the probabilistic barrier of development of resistance in the parasite...
July 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28586743/agmatine-for-combined-treatment-of-epilepsy-depression-and-cognitive-impairment-in-chronic-epileptic-animals
#13
Tanveer Singh, Neetu Bagga, Anureet Kaur, Navjot Kaur, Dinesh Yugraj Gawande, Rajesh Kumar Goel
Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits. As per present scenario, none of the antiseizure drugs have been reported successful to have ameliorative effect on epilepsy associated depression and cognitive deficits. Thus, the study was envisioned to assess an ameliorative potential of agmatine on epilepsy and its efficacy and safety for management of associated depression and cognitive deficits. The animals were made epileptic employing pentylenetetrazole (35mg/kg i...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28583598/detection-of-macrophages-in-rabbit-semen-and-their-relationship-with-semen-quality
#14
Lenka Kuželová, Jaromír Vašíček, Ján Rafay, Peter Chrenek
We aimed at the evaluating the occurrence of macrophages in rabbit semen and finding possible relationship between macrophage concentration and spermatozoa quality. The concentration of macrophages in semen samples from broiler rabbit males of lines M91 and P91 (n = 30) without overt evidence of genital tract infections was determined using monocyte/macrophage lineage antigen CD14 and flow cytometry. Then the rabbits were assigned into three groups according to the macrophage concentration in semen (MΦ1 group with less than 1 × 10(6) macrophages/mL, MΦ2 group with 1...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28578215/effects-of-agomelatine-on-pentylenetetrazole-induced-kindling-kindling-associated-oxidative-stress-and-behavioral-despair-in-mice-and-modulation-of-its-actions-by-luzindole-and-1-m-chlorophenyl-piperazine
#15
M Suhaib Azim, Nidhi B Agarwal, Divya Vohora
In view of well-evidenced antiepileptic effects of melatonin and few reports of anticonvulsant action of agomelatine, the present study investigated whether agomelatine protects against pentylenetetrazole (PTZ)-induced kindling in mice and kindling-associated oxidative stress, depression, and impairment of spatial memory. In order to explore whether effects are mediated by melatonergic or serotonergic mechanisms, 1-(m-chlorophenyl) piperazine (mCPP), selective 5HT2c receptor agonist and luzindole, melatonergic receptor antagonist, were taken as pharmacological tools...
June 1, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28576733/neuronal-zinc-%C3%AE-2-glycoprotein-is-decreased-in-temporal-lobe-epilepsy-in-patients-and-rats
#16
Ying Liu, Teng Wang, Xi Liu, Xin Wei, Tao Xu, Maojia Yin, Xueying Ding, Lijuan Mo, Lifen Chen
Zinc-α2-glycoprotein (ZAG) is a 42-kDa protein encoded by the AZGP1 gene that is known as a lipid mobilizing factor and is highly homologous to major histocompatibility complex class I family molecules. Recently, transcriptomic research has shown that AZGP1 expression is reduced in the brain tissue of epilepsy patients. However, the cellular distribution and biological role of ZAG in the brain and epilepsy are unclear. Patients with refractory temporal lobe epilepsy (TLE) and brain trauma were included in this study, and pentylenetetrazole (PTZ)-kindled rats were also used...
May 31, 2017: Neuroscience
https://www.readbyqxmd.com/read/28573454/quality-of-life-among-adolescents-living-in-residential-youth-care-do-domain-specific-self-esteem-and-psychopathology-contribute
#17
Thomas Jozefiak, Nanna S Kayed, Ingunn Ranøyen, Hanne K Greger, Jan L Wallander, Lars Wichstrøm
PURPOSE: Many adolescents living in residential youth care (RYC) institutions perceive their quality of life (QoL) to be low. Enhancing QoL is thus important, but little is known about the potential contributors to their QoL. Early interpersonal trauma and subsequent removal from home and repeated relocations to new placements are expected to affect mental health and self-esteem. We therefore investigated if domain-specific self-esteem contributed to QoL among adolescents living in RYC institutions over and beyond their levels of psychopathology...
June 1, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28570966/enhancing-quality-of-life-among-adolescents-with-bipolar-disorder-a-randomized-trial-of-two-psychosocial-interventions
#18
Lisa A O'Donnell, David A Axelson, Robert A Kowatch, Christopher D Schneck, Catherine A Sugar, David J Miklowitz
BACKGROUND: Adolescents with bipolar disorder (BD) report lower quality of life (QoL) than adolescents with other psychiatric disorders. This study compared the efficacy of family-focused therapy for adolescents (FFT-A) plus pharmacotherapy to brief psychoeducation (enhanced care, or EC) plus pharmacotherapy on self-rated QoL in adolescents with BD over 2 years. METHODS: Participants were 141 adolescents (mean age: 15.6±1.4yr) with BD I or II who had a mood episode in the previous 3 months...
April 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28570965/neurochemical-evidence-based-suggested-therapy-for-safe-management-of-epileptogenesis
#19
Navjot Kaur, Tanveer Singh, Sandeep Kumar, Rajesh Kumar Goel
Most of the clinically available antiepileptic drugs have only antiseizure effects and are reported unable to prevent epileptogenesis. In the past decade, several drugs underwent clinical trials for management of epileptogenesis, but none of the drugs tested was found effective. One of the major lacunas is availability of appropriate preclinical approaches to delineate mechanisms of epileptogenesis. Thus, the present study attempts to suggest a neurochemistry based approach for safe management of epileptogenesis...
May 29, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28542167/corticosterone-oscillations-during-mania-induction-in-the-lateral-hypothalamic-kindled-rat-experimental-observations-and-mathematical-modeling
#20
Osama A Abulseoud, Man Choi Ho, Doo-Sup Choi, Ana Stanojević, Željko Čupić, Ljiljana Kolar-Anić, Vladana Vukojević
Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK...
2017: PloS One
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