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https://www.readbyqxmd.com/read/29909237/glycosylation-as-new-pharmacological-strategies-for-diseases-associated-with-excessive-angiogenesis
#1
REVIEW
Simon Bousseau, Luisa Vergori, Raffaella Soleti, Guy Lenaers, M Carmen Martinez, Ramaroson Andriantsitohaina
Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling...
June 14, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909234/attenuation-of-inflammatory-pain-by-puerarin-in-animal-model-of-inflammation-through-inhibition-of-pro-inflammatory-mediators
#2
Muhammad Zia Ullah, Ashraf Ullah Khan, Ruqayya Afridi, Hina Rasheed, Sidra Khalid, Muhammad Naveed, Hussain Ali, Yeong Shik Kim, Salman Khan
In the current study, the puerarin was investigated for both acute Carrageenan and chronic CFA-induced inflammatory pain models. The Puerarin treatment significantly attenuated (P < 0.001) the mechanical hyperalgesia and mechanical allodynia in both Carrageenan and CFA-induced hyperalgesia. The Puerarin treatment also remarkably reduced (p < 0.001) the thermal hyperalgesic responses in both acute Carrageenan as well as chronic CFA-induced models. Furthermore, the Puerarin administration was also associated with significant inhibition of (p < 0...
June 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29908870/current-and-upcoming-therapies-for-corneal-neovascularization
#3
REVIEW
Danial Roshandel, Medi Eslani, Alireza Baradaran-Rafii, Albert Y Cheung, Khaliq Kurji, Sayena Jabbehdari, Alejandra Maiz, Setareh Jalali, Ali R Djalilian, Edward J Holland
The cornea is unique because of its complete avascularity. Corneal neovascularization (CNV) can result from a variety of etiologies including contact lens wear; corneal infections; and ocular surface diseases due to inflammation, chemical injury, and limbal stem cell deficiency. Management is focused primarily on the etiology and pathophysiology causing the CNV and involves medical and surgical options. Because inflammation is a key factor in the pathophysiology of CNV, corticosteroids and other anti-inflammatory medications remain the mainstay of treatment...
June 14, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29904944/hypoxia-inducible-factor-1%C3%AE-vascular-endothelial-growth-factor-signaling-activation-correlates-with-response-to-radiotherapy-and-its-inhibition-reduces-hypoxia-induced-angiogenesis-in-lung-cancer
#4
Hongjun Zhu, Shuanglin Zhang
Like other tumors, lung cancer must induce angiogenesis as it grows. Hypoxia-inducible factor 1α (HIF-1α) is the inducible subunit of the HIF-1 transcription factor that regulates genes involved in the response to hypoxia, some of which contributes to angiogenesis. Vascular endothelial growth factor (VEGF) is one of the genes upregulated by HIF-1 and is the primary cytokine in relation to angiogenesis. In this study we tested whether aberrant activation of hypoxia inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) pathway correlates with response to radiotherapy and examined the response of lung cancer cells to hypoxia in vitro...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904041/anti-vascular-endothelial-growth-factor-vegf-antibody-ameliorates-cartilage-degradation-in-a-rat-model-of-chronic-sports-arthritic-injury
#5
Lei Shang, Yong Xu, Changqing Shao, Chao Ma, Yanbo Feng
BACKGROUND Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of chronic sports arthritic injury. MATERIAL AND METHODS Animals were divided into 3 groups: Control (n=10), Vehicle (chronic sports arthritic injury, n=10), and Bevacizumab (chronic sports arthritic injury treated with anti-VEGF monoclonal antibody Bevacizumab, n=10)...
June 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29902977/conbercept-for-patients-with-age-related-macular-degeneration-a-systematic-review
#6
Jiaxing Zhang, Yi Liang, Juan Xie, Dong Li, Qian Hu, Xiaosi Li, Wenyi Zheng, Rui He
BACKGROUND: Conbercept is a novel vascular endothelial growth factor (VEGF) inhibitor for the treatment of wet age-related macular degeneration (AMD). This systematic review aims to assess the efficacy and safety of conbercept in the treatment of wet AMD. METHODS: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP database, and Wanfang database were searched from their earliest records to June 2017. We included randomized controlled trials (RCTs) evaluating the efficacy and safety of conbercept in wet AMD patients...
June 15, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29900046/anti-ctla-4-based-therapy-elicits-humoral-immunity-to-galectin-3-in-patients-with-metastatic-melanoma
#7
Xinqi Wu, Anita Giobbie-Hurder, Erin M Connolly, Jingjing Li, Xiaoyun Liao, Mariano Severgnini, Jun Zhou, Scott Rodig, F Stephen Hodi
The combination of CTLA-4 blockade ipilimumab (Ipi) with VEGF-A blocking antibody bevacizumab (Bev) has demonstrated favorable clinical outcomes in patients with advanced melanoma. Galectin-3 (Gal-3) plays a prominent role in tumor growth, metastasis, angiogenesis, and immune evasion. Here we report that Ipi plus Bev (Ipi-Bev) therapy increased Gal-3 antibody titers by 50% or more in approximately one third of treated patients. Antibody responses to Gal-3 were associated with higher complete and partial responses and better overall survival...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899697/anti-myeloma-effects-of-icariin-are-mediated-through-the-attenuation-of-jak-stat3-dependent-signaling-cascade
#8
Young Yun Jung, Jong Hyun Lee, Dongwoo Nam, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in human myeloma cell lines. We noted that icariin could block constitutive STAT3 phosphorylation as well as its nuclear translocation and DNA binding ability in U266 cells. Icariin also suppressed IL-6-induced STAT3 activation through the inhibition of upstream kinases (Janus activated kinase-1 and -2, and c-Src)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29896907/modulating-atp-binding-cassette-abc-transporters-in-papillary-renal-cell-carcinoma-type-2-enhances-its-response-to-targeted-molecular-therapy
#9
Rola M Saleeb, Mina Farag, Zsuzsanna Lichner, Fadi Brimo, Jenni Bartlett, Georg Bjarnason, Antonio Finelli, Fabio Rontondo, Michelle R Downes, George M Yousef
Papillary renal cell carcinoma (PRCC) is the most common non-clear cell RCCs and is known to comprise two histological subtypes. PRCC2 is more aggressive and is molecularly distinct from the other subtypes. Despite this PRCCs are treated together as one entity, and they show poor response to the current therapies that do not target pathways implicated in their pathogenesis. We have previously detected ABCC2 (an ABC transporter), VEGF and mTOR pathways to be enriched in PRCC2. In this study, we assess the therapeutic potential of targeting these pathways in PRCC2...
June 13, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29896266/anti-inflammatory-effect-of-polydeoxyribonucleotide-on-zoledronic-acid-pretreated-and-lipopolysaccharide-stimulated-raw-264-7-cells
#10
Jin-Hee Han, Junho Jung, Lakkyong Hwang, Il-Gyu Ko, Ok Hyung Nam, Mi Sun Kim, Jung-Woo Lee, Byung-Joon Choi, Deok-Won Lee
Bisphosphonates are generally used as therapeutic agents for bone diseases. However, previous reports on bisphosphonates-related osteonecrosis of the jaw (BRONJ) demonstrated that inflammation triggers and worsens the disease. Recently, polydeoxynucleotide (PDRN), an A2A receptor agonist, has been suggested for the treatment of various diseases and broadly studied for its anti-inflammatory effect. The present study aimed to measure the effect of PDRN on macrophage cells treated with zoledronic acid (ZA) and lipopolysaccharide (LPS)...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29894822/anti-angiogenic-treatment-bevacizumab-improves-the-responsiveness-of-photodynamic-therapy-in-colorectal-cancer
#11
Cheng-Liang Peng, Hua-Ching Lin, Wei-Lun Chiang, Ying-Hsia Shih, Ping-Fang Chiang, Tsai-Yueh Luo, Chun-Chia Cheng, Ming-Jium Shieh
Photodynamic therapy (PDT) is a new treatment utilizing the combined action of photosensitizers and light for the treatment of various cancers. The mechanisms for tumor destruction after PDT include direct tumor cell kill by singlet oxygen species (OS), indirect cell kill via vascular damage, and an elicited immune response. However, it has been reported that many cellular activators, including vascular endothelial growth factor (VEGF), are produced by tumor cells after PDT. In this study, we demonstrate that meta-tetra(hydroxyphenyl) chlorin (mTHPC)-based photodynamic therapy combined with bevacizumab (Avastin™), an anti-VEGF neutralizing monoclonal antibody that blocks the binding of VEGF to its receptor, can enhance the effectiveness of each treatment modality...
June 9, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29894487/impact-of-chronic-sexual-abuse-and-depression-on-inflammation-and-wound-healing-in-the-female-reproductive-tract-of-hiv-uninfected-and-hiv-infected-women
#12
Mimi Ghosh, Jason Daniels, Maria Pyra, Monika Juzumaite, Mariel Jais, Kerry Murphy, Tonya N Taylor, Seble Kassaye, Lorie Benning, Mardge Cohen, Kathleen Weber
Sexual violence is associated with increased risk of HIV acquisition/transmission in women. Forced sex can result in physical trauma to the reproductive tract as well as severe psychological distress. However, immuno-biological mechanisms linking sexual violence and HIV susceptibility are incompletely understood. Using the Women's Interagency HIV Study repository, a total of 77 women were selected to form 4 groups, stratified by HIV serostatus, in the following categories: 1) no sexual abuse history and low depressive symptom score (below clinically significant cut-off, scores <16) (Control); 2) no sexual abuse history but high depressive symptom score, ≥16 (Depression); 3) chronic sexual abuse exposure and low depressive symptom score (Abuse); 4) chronic sexual abuse exposure and high depressive symptom score (Abuse+Depression)...
2018: PloS One
https://www.readbyqxmd.com/read/29890255/a-novel-ca-2-current-blocker-promotes-angiogenesis-and-cardiac-healing-after-experimental-myocardial-infarction-in-mice
#13
Guozhen Cui, Qiqi Xin, Hisa Hui Ling Tseng, Maggie PuiMan Hoi, Yan Wang, Binrui Yang, InLeng Choi, Yuqiang Wang, Rong Yuan, Keji Chen, Weihong Cong, Simon MingYuen Lee
We previously reported a novel danshensu derivative (R)-(3,5,6-Trimethylpyrazinyl) methyl-2-acetoxy-3-(3,4-diacetoxyphenyl) propanoate (ADTM) that exhibited promising cardiovascular protective activities, such as antioxidant and antiplatelet activities, as well as arterial relaxation. Particularly, ADTM treatment for 24 h exhibited anti-oxidative activity and effectively protected against acute myocardial infarction (MI) in a rat model. Here, we further investigated the pharmacological actions of 14 days of treatment with ADTM in alleviating and restoring the MI size by stimulating revascularization...
June 8, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29890157/ginkgolide-k-promotes-angiogenesis-in-a-middle-cerebral-artery-occlusion-mouse-model-via-activating-jak2-stat3-pathway
#14
Meng Chen, Wenyan Zou, Miaomiao Chen, Liang Cao, Jianhua Ding, Wei Xiao, Gang Hu
Ginkgolide K (GK) is a new compound extracted from the leaves of Ginkgo biloba, which has been recognized to exert anti-oxidative stress and neuroprotective effect on ischemic stroke. While whether it plays an enhanced effect on angiogenesis during ischemic stroke remains unknown. The aim of this study was to investigate the effect of ginkgolide K on promoting angiogenesis as well as the protective mechanism after cerebral ischemia-reperfusion. Using the transient middle cerebral artery occlusion (tMCAO) mouse model, we found that GK (3...
June 8, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29888658/-blinding-spontaneous-suprachoroidal-haemorrhage-in-anticoagulant-taking-wet-amd-patients
#15
Mónika Ecsedy, Béla Csákány, Illés Kovács, Miklós Resch, Zoltán Nagy, Zsuzsa Récsán
We present cases of blinding spontaneous suprachoroidal haemorrhage in anticoagulant taking wet-AMD patients. A retrospective study has been performed to present the clinical course, management and final outcome of spontaneous suprachoroidal haemorrhage in 7 eyes of six age-related macular degeneration patients seen in our clinic from January 2016 to April 2017. All patients were on chronic oral anticoagulant therapy because of cardiovascular disorder. In one patient, haematological disorder was also present modifying significantly the haemostasis...
June 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29888133/shift-in-vegfa-isoform-balance-towards-more-angiogenic-variants-is-associated-with-tumor-stage-and-differentiation-of-human-hepatocellular-carcinoma
#16
Mikhail S Chesnokov, Polina A Khesina, Darya A Shavochkina, Inna F Kustova, Leonid M Dyakov, Olga V Morozova, Nikolai S Mugue, Nikolay E Kudashkin, Ekaterina A Moroz, Yuri I Patyutko, Natalia L Lazarevich
Background: Hepatocellular carcinoma (HCC) is the most common and aggressive type of malignant liver tumor. HCC progression depends significantly on its vascularization and formation of new blood vessels. Vascular endothelial growth factor A (VEGFA) is a crucial regulator of tumor vascularization and components of VEGF-induced cell signaling pathways are important targets of therapeutical drugs that demonstrated the highest efficiency in case of advanced HCC (sorafenib and regorafenib)...
2018: PeerJ
https://www.readbyqxmd.com/read/29886834/verbascoside-attenuates-rac-1-and-hif-1%C3%AE-signaling-cascade-in-colorectal-cancer-cells
#17
Mohammad Nabiuni, Danial Seyfi, Seyed Bahram Behzad, Kazem Parivar, Mohammad Tahmaseb, Elaheh Amini
OBJECTIVE: Metastasis phenotype is considered as a main challenge in colon cancer therapeutic methods. Furthermore, the side effects of conventional colorectal cancer treatment methods, has attracted a lot of attention into natural ingredients. The aim of the study was to assess the molecular mechanism of verbascoside as natural bio-compound in human HT29 colon cancer cells. METHODS: HT29 cells were cultured in RPMI-1640 medium containing 10% FBS and 1% penicillin/streptomycin at 37˚C and 5% CO2...
June 10, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29886729/mechanistic-study-of-the-in-vitro-and-in-vivo-inhibitory-effects-of-protocatechuic-acid-and-syringic-acid-on-vegf-induced-angiogenesis
#18
Jiamiao Hu, Shaoling Lin, Jim Junhui Huang, Peter C K Cheung
The anti-angiogenic activities of two structurally similar phenolics protocatechuic acid (PA) and syringic acid (SA) were investigated. In vitro study using HUVECs demonstrated that both PA and SA (at 25 μM) significantly (p < 0.05) inhibited VEGF-induced cell proliferation by 22.68 ± 5.6% and 21.93 ± 2.0%, respectively; cell migration by 50.04 ± 3.3% and 39.72 ± 4.7%, respectively; cell invasion by 44.16 ± 4.23% and 51.90 ± 2.73%, respectively; and cellular ROS generation by 11.48 ± 6.32% and 21...
June 10, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29885517/does-metronomic-chemotherapy-induce-tumor-angiogenic-dormancy-a-review-of-available-preclinical-and-clinical-data
#19
Gianfranco Natale, Guido Bocci
Tumor dormancy is the ability of cancer cells to survive in a non-proliferating state. This condition can depend on three main mechanisms: cell cycle arrest (quiescence or cell dormancy), immunosurveillance (immunologic dormancy), or lack of functional blood vessels (angiogenic dormancy). In particular, under angiogenic dormancy, cancer cell proliferation is counterbalanced by apoptosis owing to poor vascularization, impeding tumor mass expansion beyond a microscopic size, with an asymptomatic and non-metastatic state...
June 6, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29883374/anti-inflammatory-effects-of-angelica-sinensis-oliv-diels-water-extract-on-raw-264-7-induced-with-lipopolysaccharide
#20
Young-Jin Kim, Ji Young Lee, Hyun-Ju Kim, Do-Hoon Kim, Tae Hee Lee, Mi Suk Kang, Wansu Park
The dry root of Angelica sinensis (Oliv.) Diels, also known as &ldquo;female ginseng&rdquo;, is a popular herbal drug amongst women, used to treat a variety of health issues and cardiovascular diseases. The aim of this study is to evaluate the detailed molecular mechanism for anti-inflammatory effects of Angelica sinensis root water extract (ASW). The anti-inflammatory effect of ASW on lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages was evaluated by the tetrazolium-based colorimetric assay (MTT), Griess reagent assay, multiplex cytokine assay, real time reverse transcription polymerase chain reaction (RT-PCR), and Fluo-4 calcium assay...
May 21, 2018: Nutrients
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