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https://www.readbyqxmd.com/read/27909950/hatt-a-phase-iv-single-arm-open-label-study-of-sorafenib-in-taiwanese-patients-with-advanced-hepatocellular-carcinoma
#1
Shi-Ming Lin, Sheng-Nan Lu, Ping-Tsung Chen, Long-Bin Jeng, Shinn-Cherng Chen, Chi-Tan Hu, Sien-Sing Yang, Marie-Aude Le Berre, Xuan Liu, David Y Mitchell, Klaas Prins, Joachim Grevel, Carol A E Peña, Gerold Meinhardt
BACKGROUND: Sorafenib significantly improves survival in patients with advanced hepatocellular carcinoma (HCC). This phase IV study assessed sorafenib efficacy/safety in Taiwanese patients with advanced HCC and Child-Pugh A status. METHODS: All patients received 400 mg sorafenib BID. Safety, efficacy, sorafenib pharmacokinetics, and Child-Pugh progression were evaluated. A hand-foot skin reaction (HFSR) prevention substudy assessed HFSR incidence and grade/severity and time to HFSR in 29 and 34 patients randomized to corticosteroid and noncorticosteroid ointments, respectively, and in 88 nonrandomized patients...
December 1, 2016: Hepatology International
https://www.readbyqxmd.com/read/27909861/surgical-reconstruction-for-fibular-hemimelia
#2
REVIEW
Dror Paley
Fibular hemimelia presents with foot deformity and leg length discrepancy. Previous classifications have focused on the degree of fibular deficiency rather than the type of foot deformity. Published methods of surgical reconstruction have often failed due to residual or recurrent foot deformity. The purpose of this report is to introduce new classification and reconstruction methods. The Paley SHORDT procedure is used to stabilize the ankle when there is a hypoplastic distal fibula with a dynamic valgus deformity...
December 1, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27909032/midterm-outcomes-of-polyvinyl-alcohol-hydrogel-hemiarthroplasty-of-the-first-metatarsophalangeal-joint-in-advanced-hallux-rigidus
#3
Timothy R Daniels, Alastair S E Younger, Murray J Penner, Kevin J Wing, Sara Lyn Miniaci-Coxhead, Ellie Pinsker, Mark Glazebrook
BACKGROUND: Hallux rigidus is the most common arthritic condition of the foot. A randomized clinical trial of first metatarsophalangeal (MTP) joint hemiarthroplasty with a polyvinyl alcohol (PVA) hydrogel implant (Cartiva) demonstrated pain relief and functional outcomes equivalent to first MTP arthrodesis at 2 years postoperation, with no cases of implant fragmentation, wear, or bone loss. We prospectively determined 5-year outcomes of first MTP hemiarthroplasty with the PVA hydrogel implant...
November 30, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27908524/genetic-correlation-between-alcohol-preference-and-conditioned-fear-exploring-a-functional-relationship
#4
Julia A Chester, Marcus M Weera
Post-traumatic stress disorder (PTSD) and alcohol-use disorders have a high rate of co-occurrence, possibly because they are regulated by common genes. In support of this idea, mice selectively bred for high (HAP) alcohol preference show greater fear potentiated startle (FPS), a model for fear-related disorders such as PTSD, compared to mice selectively bred for low (LAP) alcohol preference. This positive genetic correlation between alcohol preference and FPS behavior suggests that the two traits may be functionally related...
November 23, 2016: Alcohol
https://www.readbyqxmd.com/read/27908459/three-single-leg-standing-tests-for-clinical-assessment-of-chronic-plantar-heel-pain-syndrome-static-stance-half-squat-and-heel-rise
#5
B Saban, Y Masharawi
OBJECTIVE: To assess reliability and validity of three single leg standing clinical tests in patients with plantar heel pain syndrome (PHPS). DESIGN: Cross-sectional reliability study. PARTICIPANTS: Forty patients diagnosed with PHPS. MAIN OUTCOME MEASURES: Patients stood on their affected foot in a static stance for up to 30seconds, a half squat for up to 10 repetitions, and a heel rise for up to 10 repetitions. The first sensation of pain (p1) determined the termination of each test, and established a positive test result...
June 29, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27905343/unilateral-hemorrhagic-maculopathy-an-uncommon-manifestation-of-hand-foot-and-mouth-disease
#6
Manish Tandon, Abhishek Gupta, Priyanka Singh, Gnanavelu N Subathra
Hand, foot, and mouth disease (HFD) is a common systemic infection occurring in childhood or immunocompromised adults caused by enteroviruses, the most common being coxsackievirus A16 and enterovirus 71. It is characterized by maculopapular eruptions over the hands and feet and ulcerative stomatitis. Ocular involvement is a rare complication and commonly manifests as inflammatory macular pathology. We report a case of HFD in an immunocompetent adult male with unilateral ocular involvement presenting as hemorrhagic maculopathy and its management with complete anatomical and functional recovery...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27904801/midfoot-and-forefoot-involvement-in-lateral-ankle-sprains-and-chronic-ankle-instability-part-1-anatomy-and-biomechanics
#7
John J Fraser, Mark A Feger, Jay Hertel
: The modern human foot is the culmination of more than five million years of evolution. The ankle-foot complex absorbs forces during loading, accommodates uneven surfaces, and acts as a lever for efficient propulsion. The ankle-foot complex has six independent functional segments that should be understood for proper assessment and treatment of foot and ankle injuries: the shank, rearfoot, midfoot, lateral forefoot, and the medial forefoot. The compliance of the individual segments of the foot is dependent on velocity, task, and active and passive coupling mechanisms within each of the foot segments...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904796/functional-hop-tests-and-tuck-jump-assessment-scores-between-female-division-i-collegiate-athletes-participating-in-high-versus-low-acl-injury-prone-sports-a-cross-sectional-analysis
#8
Philipp Hoog, Meghan Warren, Craig A Smith, Nicole J Chimera
BACKGROUND: Although functional tests including the single leg hop (SLH), triple hop (TH), cross over hop (COH) for distance, and the tuck jump assessment (TJA) are used for return to play (RTP) criteria for post anterior cruciate ligament (ACL) injury, sport-specific baseline measurements are limited. PURPOSE: The purpose of this study was to examine differences in SLH, TH, and COH distance and limb symmetry index (LSI), as well as total scores, number of jumps, and individual flaws of the TJA in 97 injury-free Division I (DI) collegiate female student athletes participating in ACL injury prone vs...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904791/current-concepts-in-biomechanical-interventions-for-patellofemoral-pain
#9
Richard W Willy, Erik P Meira
: Patellofemoral pain (PFP) has historically been a complex and enigmatic issue. Many of the factors thought to relate to PFP remain after patients' symptoms have resolved making their clinical importance difficult to determine. The tissue homeostasis model proposed by Dye in 2005 can assist with understanding and implementing biomechanical interventions for PFP. Under this model, the goal of interventions for PFP should be to re-establish patellofemoral joint (PFJ) homeostasis through a temporary alteration of load to the offended tissue, followed by incrementally restoring the envelope of function to the baseline level or higher...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27903628/the-role-of-plantigrady-and-heel-strike-in-the-mechanics-and-energetics-of-human-walking-with-implications-for-the-evolution-of-the-human-foot
#10
James T Webber, David A Raichlen
Human bipedal locomotion is characterized by a habitual heel-strike (HS) plantigrade gait, yet the significance of walking foot-posture is not well understood. To date, researchers have not fully investigated the costs of non-heel-strike (NHS) walking. Therefore, we examined walking speed, walk-to-run transition speed, estimated locomotor costs (lower limb muscle volume activated during walking), impact transient (rapid increase in ground force at touchdown) and effective limb length (ELL) in subjects (n=14) who walked at self-selected speeds using HS and NHS gaits...
December 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27900895/diabetes-education-should-cover-foot-self-care
#11
(no author information available yet)
Patients with diabetes provide 99% of their own care but do not always practise foot care, especially if they are older people with functional or cognitive problems. Incidence of diabetes has increased exponentially and it is now the most common chronic condition affecting older people.
November 30, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27900272/return-to-physical-activity-after-gastrocnemius-recession
#12
Camelia Tang Qian Ying, Sean Lai Wei Hong, Bing Howe Lee, Gowreeson Thevendran
AIM: To prospectively investigate the time taken and patients' ability to resume preoperative level of physical activity after gastrocnemius recession. METHODS: Endoscopic gastrocnemius recession (EGR) was performed on 48 feet in 46 consecutive sportspersons, with a minimum follow-up of 24 mo. The Halasi Ankle Activity Score was used to quantify the level of physical activity. Time taken to return to work and physical activity was recorded. Functional outcomes were evaluated using the short form 36 (SF-36), American Orthopedic Foot and Ankle Society (AOFAS) Hindfoot score and modified Olerud and Molander (O and M) scores respectively...
November 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/27896688/design-simulation-and-modelling-of-auxiliary-exoskeleton-to-improve-human-gait-cycle
#13
O Ashkani, A Maleki, N Jamshidi
Exoskeleton is a walking assistance device that improves human gait cycle through providing auxiliary force and transferring physical load to the stronger muscles. This device takes the natural state of organ and follows its natural movement. Exoskeleton functions as an auxiliary device to help those with disabilities in hip and knee such as devotees, elderly farmers and agricultural machinery operators who suffer from knee complications. In this research, an exoskeleton designed with two screw jacks at knee and hip joints...
November 28, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27895574/robot-assisted-rehabilitation-of-ankle-plantar-flexors-spasticity-a-3-month-study-with-proprioceptive-neuromuscular-facilitation
#14
Zhihao Zhou, Yao Sun, Ninghua Wang, Fan Gao, Kunlin Wei, Qining Wang
In this paper, we aim to investigate the effect of proprioceptive neuromuscular facilitation (PNF)-based rehabilitation for ankle plantar flexors spasticity by using a Robotic Ankle-foot Rehabilitation System (RARS). A modified robot-assisted system was proposed, and seven poststroke patients with hemiplegic spastic ankles participated in a 3-month robotic PNF training. Their impaired sides were used as the experimental group, while their unimpaired sides as the control group. A robotic intervention for the experimental group started from a 2-min passive stretching to warming-up or relaxing the soleus and gastrocnemius muscles and also ended with the same one...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27894024/foot-placement-during-error-and-pedal-applications-in-naturalistic-driving
#15
Yuqing Wu, Linda Ng Boyle, Daniel McGehee, Cheryl A Roe, Kazutoshi Ebe, James Foley
Data from a naturalistic driving study was used to examine foot placement during routine foot pedal movements and possible pedal misapplications. The study included four weeks of observations from 30 drivers, where pedal responses were recorded and categorized. The foot movements associated with pedal misapplications and errors were the focus of the analyses. A random forest algorithm was used to predict the pedal application types based the video observations, foot placements, drivers' characteristics, drivers' cognitive function levels and anthropometric measurements...
November 25, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27891612/neurovascular-mechanisms-underlying-augmented-cold-induced-reflex-cutaneous-vasoconstriction-in-human-hypertension
#16
Jody L Greaney, W Larry Kenney, Lacy M Alexander
Despite ample evidence of dysregulated sympathetic control of the peripheral vasculature in hypertension, no studies have examined integrated neurovascular function during cold stress in hypertensive adults (HTN). We hypothesized that (1) whole-body cooling would elicit greater cutaneous vasoconstriction and greater increases in skin sympathetic nervous system activity (SSNA) in HTN (n = 14; 56 ± 2 yrs) compared to age-matched normotensive adults (NTN; n = 14; 55 ± 2 yrs) and (2) augmented reflex vasoconstriction in HTN would be mediated by an increase in cutaneous vascular adrenergic sensitivity and a greater contribution of non-adrenergic sympathetic co-transmitters...
November 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27890830/time-course-of-glial-changes-in-the-hyperhomocysteinemia-model-of-vascular-cognitive-impairment-and-dementia-vcid
#17
Tiffany L Sudduth, Erica M Weekman, Brittani R Price, Jennifer L Gooch, Abigail Woolums, Christopher M Norris, Donna M Wilcock
Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia behind Alzheimer's disease (AD) and is a frequent co-morbidity with AD. Despite its prevalence, little is known about the molecular mechanisms underlying the cognitive dysfunction resulting from cerebrovascular disease. Astrocytic end-feet almost completely surround intraparenchymal blood vessels in the brain and express a variety of channels and markers indicative of their specialized functions in the maintenance of ionic and osmotic homeostasis and gliovascular signaling...
November 25, 2016: Neuroscience
https://www.readbyqxmd.com/read/27890633/comparison-analysis-of-micrornas-in-response-to-ev71-and-ca16-infection-in-human-bronchial-epithelial-cells-by-high-throughput-sequencing-to-reveal-differential-infective-mechanisms
#18
Yajie Hu, Jie Song, Longding Liu, Jing Li, Beibei Tang, Ying Zhang, Jingjing Wang, Lichun Wang, Shengtao Fan, Ming Feng, Qihan Li
Hand, foot, and mouth disease (HFMD) mainly caused by Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) infections which presented significantly different clinical manifestations. Nevertheless, the factors underlying these differences remain unclear. Recently, the functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. Here, we performed comprehensive miRNA profiling in EV71- and CA16-infected human bronchial epithelial (16HBE) cells at multiple time points using high-throughput sequencing...
November 24, 2016: Virus Research
https://www.readbyqxmd.com/read/27890134/the-relationship-between-arch-height-and-foot-length-implications-for-size-grading
#19
Matthew Hill, Roozbeh Naemi, Helen Branthwaite, Nachiappan Chockalingam
OBJECTIVE: Medial longitudinal Arch Height is synonymous with classifying foot type and conversely foot function. Detailed knowledge of foot anthropometry is essential in the development of ergonomically sound footwear. Current Footwear design incorporates a direct proportionate scaling of instep dimensions with those of foot length. The objective of this paper is to investigate if a direct proportional relationship exists between human arch height parameters and foot length in subjects with normal foot posture...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27888788/alternate-hot-and-cold-application-in-the-management-of-heel-pain-a-pilot-study
#20
Dhananjay Arankalle, Jon Wardle, Pradeep M K Nair
BACKGROUND: Despite a long-standing tradition of naturopathic physical therapy and hydrotherapy use in the treatment of musculoskeletal conditions, neither naturopathy, nor specific aspects of hydrotherapy have been tested for efficacy in the treatment of heel pain. METHODS: Patients (n=20) were assigned to standard naturopathic physiotherapy care (NPC) with two adjuvant therapy groups: a control group (therapeutic ultrasound, n=10), or alternating compresses (n=10)...
September 19, 2016: Foot
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