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https://www.readbyqxmd.com/read/29235129/association-of-gene-polymorphisms-of-pattern-recognition-receptor-signalling-pathway-with-the-risk-and-severity-of-hand-foot-and-mouth-disease-caused-by-enterovirus-71-in-chinese-han-population
#1
Ya-Ping Li, Mei Li, Xiao-Li Jia, Hui-Ling Deng, Wen-Jun Wang, Feng-Ping Wu, Jun Wang, Shuang-Suo Dang
Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex- and age-matched children was included as a control...
December 12, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29227525/functional-electrical-stimulation-and-ankle-foot-orthoses-provide-equivalent-therapeutic-effects-on-foot-drop-a-meta-analysis-providing-direction-for-future-research
#2
Sarah Prenton, Kristen L Hollands, Laurence P J Kenney, Pornsuree Onmanee
OBJECTIVE: To compare the randomized controlled trial evidence for therapeutic effects on walking of functional electrical stimulation and ankle foot orthoses for foot drop caused by central nervous system conditions. DATA SOURCES: MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, REHABDATA, PEDro, NIHR Centre for Reviews and Dissemination, Scopus and clinicaltrials.gov. STUDY SELECTION: One reviewer screened titles/abstracts...
November 17, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29224059/lower-complication-rate-and-faster-return-to-sports-in-patients-with-acute-syndesmotic-rupture-treated-with-a-new-knotless-suture-button-device
#3
Christian Colcuc, Marc Blank, Thomas Stein, Florian Raimann, Sanjay Weber-Spickschen, Sebastian Fischer, Reinhard Hoffmann
PURPOSE: Suture button devices for tibiofibular syndesmosis injuries provide semirigid dynamic stabilization, but complications including knot irritation have been reported. No randomized trials of the new knotless suture button devices have been performed. We hypothesized that knotless suture button devices eliminate knot irritation and facilitate quicker return to sports. This study was performed to compare the clinical outcomes, complication rates, and time to return to sports between a new knotless suture button device and syndesmotic screw fixation...
December 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29222948/force-coordination-strategies-in-on-water-single-sculling-are-asymmetries-related-to-better-rowing-performance
#4
John Warmenhoven, Richard Smith, Conny Draper, Andrew Harrison, Norma Bargary, Stephen Cobley
Asymmetries of the rowing stroke cycle have been assessed with reference to kinematics and foot-force measures in laboratory testing environments. It remains unclear how asymmetries in propulsive kinetic measures are related to on-water rowing performance. A new approach for the evaluation of both global and local asymmetries across the entire movement was used to assess the continuous role of asymmetries and whether these change according to level of competitive representation. Twenty seven highly skilled female rowers (national and international competition level), rowing at 32 strokes per minute in a single scull boat were evaluated...
December 9, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29216771/survey-of-the-functional-priorities-in-patients-with-disability-due-to-neuromuscular-disorders
#5
Nivedita U Jerath, Kevin Simoens, Dylan Mann, Steph Kollasch, Nicole Grosland, Karim A Malik, Chandan G Reddy
TITLE: Survey of the functional priorities in patients with disability due to neuromuscular disorders. OBJECTIVE: This study attempts to determine the functional priorities for patients with neuromuscular disorders. METHODS: A survey asking about functional priorities with respect to activities of daily living, ankle foot orthotic design, and assistive device design, was distributed to patients with neuromuscular disorders to assess the needs of patients from their perspectives...
December 8, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29215738/electronic-cigarette-a-recent-update-of-its-toxic-effects-on-humans
#6
REVIEW
Shu-Jie Huang, Yan-Ming Xu, Andy T Y Lau
Electronic cigarettes (e-cigarettes), battery-powered and liquid-vaporizing devices, were invented to replace the conventional cigarette (c-cigarette) smoking for the sake of reducing the adverse effects on multiple organ systems that c-cigarettes have induced. Although some of the identified harmful components in e-cigarettes were alleged to be measured in lower quantity than those in c-cigarettes, researchers unveiled that the toxic effects of e-cigarettes should not be understated. This review is sought for an attempt to throw light on several typical types of e-cigarette components (tobacco-specific nitrosamines, carbonyl compounds, and volatile organic compounds) by revealing their possible impacts on human bodies through different action mechanisms characterized by alteration of specific biomarkers on cellular and molecular levels...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215571/application-of-the-superelastic-niti-spring-in-ankle-foot-orthosis-afo-to-create-normal-ankle-joint-behavior
#7
Amirhesam Amerinatanzi, Hashem Zamanian, Narges Shayesteh Moghaddam, Ahmadreza Jahadakbar, Mohammad Elahinia
Hinge-based Ankle Foot Orthosis (HAFO) is one of the most common non-surgical solutions for the foot drop. In conventional HAFOs, the ankle joint is almost locked, and plantar flexion is restricted due to the high stiffness of the hinge mechanism. This often leads to a rigid walking gate cycle, poor muscle activity, and muscle atrophy. Since the ankle torque-angle loop has a non-linear profile, the use of a superelastic NiTi spring within the hinge, due to its nonlinear behavior, could recreate a close-to-normal stiffness of the normal ankle joint, which, in turn, could create a more natural walk...
December 7, 2017: Bioengineering
https://www.readbyqxmd.com/read/29215039/semantic-discrimination-impacts-tdcs-modulation-of-verb-processing
#8
Valentina Niccolai, Anne Klepp, Peter Indefrey, Alfons Schnitzler, Katja Biermann-Ruben
Motor cortex activation observed during body-related verb processing hints at simulation accompanying linguistic understanding. By exploiting the up- and down-regulation that anodal and cathodal transcranial direct current stimulation (tDCS) exert on motor cortical excitability, we aimed at further characterizing the functional contribution of the motor system to linguistic processing. In a double-blind sham-controlled within-subjects design, online stimulation was applied to the left hemispheric hand-related motor cortex of 20 healthy subjects...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212943/the-cellular-chaperone-heat-shock-protein-90-is-required-for-foot-and-mouth-disease-virus-capsid-precursor-processing-and-assembly-of-capsid-pentamers
#9
Joseph Newman, Amin S Asfor, Stephen Berryman, Terry Jackson, Stephen Curry, Tobias J Tuthill
Productive picornavirus infection requires the hijack of host cell pathways to aid with the different stages of virus entry, synthesis of the viral polyprotein and viral genome replication. Many picornaviruses, including foot-and-mouth disease virus (FMDV), assemble capsids via the multimerisation of several copies of a single capsid precursor protein into a pentameric subunit which further encapsidates the RNA. Pentamer formation is preceded by co- and post-translational modification of the capsid precursor (P1-2A) by viral and cellular enzymes, and the subsequent rearrangement of P1-2A into a structure amenable to pentamer formation...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29207011/astragaloside-iv-prevents-kidney-injury-caused-by-iatrogenic-hyperinsulinemia-in-a-streptozotocin%C3%A2-induced-diabetic-rat-model
#10
Ke-Qiang He, Wei-Zu Li, Xiao-Qing Chai, Yan-Yan Yin, Yan Jiang, Wei-Ping Li
Diabetic patients are able to manage their blood glucose with exogenous insulin but, ultimately, remain at risk of diabetic nephropathy (DN). Long‑term use of insulin may lead to iatrogenic hyperinsulinemia, which has been suggested to cause kidney injury. However, there are no effective interventions for iatrogenic hyperinsulinemia leading to kidney damage. In the present paper, the hypothesis that astragaloside IV (AS‑IV), a novel saponin purified from Astragalus membranaceus (Fisch) Bunge, may prevent DN in iatrogenic hyperinsulinemic diabetic rats through antioxidative and anti‑inflammatory mechanisms was investigated...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205209/foot-mechanics-in-young-women-are-altered-after-walking-in-high-heeled-shoes
#11
Sławomir Winiarski, Alicja Rutkowska-Kucharska, Paweł Zostawa, Natalia Uścinowicz-Zostawa, Sebastian Klich
PURPOSE: Nowadays, fashion has caused that many young women are wearing high-heeled shoes. Therefore, the aim of this study was to examine the effects of long-term walking in high-heeled shoes on the foot mechanics during barefoot gait. METHODS: Forty-three young women (22 ± 2.1 years) divided into two groups participated in this retrospective cohort study. The first group was composed of women who frequently wear high-heeled footwear. The second, infrequent wearers group, consisted of women who preferred flat-heeled shoes...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29204271/genome-sequencing-and-analysis-of-the-first-spontaneous-nanosilver-resistant-bacterium-proteus-mirabilis-strain-scdr1
#12
Amr T M Saeb, Khalid A Al-Rubeaan, Mohamed Abouelhoda, Manojkumar Selvaraju, Hamsa T Tayeb
Background: P. mirabilis is a common uropathogenic bacterium that can cause major complications in patients with long-standing indwelling catheters or patients with urinary tract anomalies. In addition, P. mirabilis is a common cause of chronic osteomyelitis in Diabetic foot ulcer (DFU) patients. We isolated P. mirabilis SCDR1 from a Diabetic ulcer patient. We examined P. mirabilis SCDR1 levels of resistance against Nanosilver colloids, the commercial Nanosilver and silver containing bandages and commonly used antibiotics...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29198471/sympatric-speciation-in-the-genomic-era
#13
REVIEW
Andrew D Foote
Sympatric speciation has been of key interest to biologists investigating how natural and sexual selection drive speciation without the confounding variable of geographic isolation. The advent of the genomic era has provided a more nuanced and quantitative understanding of the different and often complex modes of speciation by which sympatric sister taxa arose, and a reassessment of some of the most compelling empirical case studies of sympatric speciation. However, I argue that genomic studies based on contemporary populations may never be able to provide unequivocal evidence of true primary sympatric speciation, and there is a need to incorporate palaeogenomic studies into this field...
November 30, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/29198401/wounded-to-the-bone-digital-microscopic-analysis-of-traumas-in-a-medieval-mass-grave-assemblage-sandbjerget-denmark-ad-1300-1350
#14
Alexandra Boucherie, Marie Louise S Jørkov, Martin Smith
Battle-related mass burials are considered the most unequivocal evidence of past violence. However, most published studies involve only macroscopic analysis of skeletal remains, commonly arriving only at broad conclusions regarding trauma interpretation. The current study considers a possible avenue for achieving both greater detail and accuracy through digital microscopy. Patterns of injury were investigated among 45 individuals from a Medieval Danish mass grave (Sandbjerget, AD 1300-1350). Injuries were recorded on every anatomical element, except hand and foot bones...
December 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29197918/the-potential-of-ultrasonography-in-the-evaluation-of-foot-orthotics-therapy
#15
REVIEW
Daniel Petcu, Delia Alexandrina Mitrea, Cosmina Ioana Bondor, Elena Rodica Perciun
Foot orthotics prescription is based on the foot functioning paradigms with tissue stress theory being in avant-garde. The main goal of orthotic therapy is to reduce the internal tissue's pathological stresses in the foot structures. Traditionally, ultrasound scanning technique depicts anatomic related data of both common and uncommon pathology encountered in the clinical practice, helping in diagnosing, treating and evaluating, which are equally important for the practitioners. Its accessibility, compared to biomechanical modelling, makes this technique a valuable tool in the field of foot and ankle disorders...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29196741/bayesian-inference-of-epidemiological-parameters-from-transmission-experiments
#16
Ben Hu, Jose L Gonzales, Simon Gubbins
Epidemiological parameters for livestock diseases are often inferred from transmission experiments. However, there are several limitations inherent to the design of such experiments that limits the precision of parameter estimates. In particular, infection times and latent periods cannot be directly observed and infectious periods may also be censored. We present a Bayesian framework accounting for these features directly and employ Markov chain Monte Carlo techniques to provide robust inferences and quantify the uncertainty in our estimates...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192934/predicting-injury-in-professional-baseball-pitchers-from-delivery-mechanics-a-statistical-model-using-quantitative-video-analysis
#17
E Grant Sutter, Justin Orenduff, Will J Fox, Joshua Myers, Grant E Garrigues
Baseball pitching imposes significant stress on the upper extremity and can lead to injury. Many studies have attempted to predict injury through pitching mechanics, most of which have used laboratory setups that are often not practical for population-based analysis. This study sought to predict injury risk in professional baseball pitchers using a statistical model based on video analysis evaluating delivery mechanics in a large population. Career data were collected and video analysis was performed on a random sample of former and current professional pitchers...
November 30, 2017: Orthopedics
https://www.readbyqxmd.com/read/29191634/a-mathematical-analysis-to-address-the-6-degree-of-freedom-segmental-power-imbalance
#18
Anahid Ebrahimi, John D Collins, Thomas M Kepple, Kota Z Takahashi, Jill S Higginson, Steven J Stanhope
Segmental power is used in human movement analyses to indicate the source and net rate of energy transfer between the rigid bodies of biomechanical models. Segmental power calculations are performed using segment endpoint dynamics (kinetic method). A theoretically equivalent method is to measure the rate of change in a segment's mechanical energy state (kinematic method). However, these two methods have not produced experimentally equivalent results for segments proximal to the foot, with the difference in methods deemed the "power imbalance...
November 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29189883/arthroscopic-treatment-combined-with-the-ankle-stabilization-procedure-is-effective-for-sinus-tarsi-syndrome-in-patients-with-chronic-ankle-instability
#19
Sheng-Kun Li, Yu-Jie Song, Hong Li, Baofu Wei, Ying-Hui Hua, Hong-Yun Li
PURPOSE: This study aimed to investigate the results of arthroscopic treatment combined with ankle stabilization procedure for sinus tarsi syndrome (STS) in patients with chronic ankle instability (CAI). METHODS: A total of 57 patients (31 males and 26 females, average age 29.9 ± 8.4 years ranging from 15 to 52 years) with STS and CAI who accepted operation from 2013 to 2015 were included in this retrospective study. Surgical procedures included thorough tarsal sinus debridement and repair or reconstruction of lateral ankle ligaments according to the quality of ligaments...
November 30, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29189156/post-stroke-constraint-induced-movement-therapy-increases-functional-recovery-angiogenesis-and-neurogenesis-with-enhanced-expression-of-hif-1%C3%AE-and-vegf
#20
Ce Li, Bei Zhang, Yulian Zhu, Yingying Li, Peile Liu, Beiyao Gao, Shan Tian, Liang Du, Yu-Long Bai
BACKGROUND: Constraint-Induced Movement Therapy (CIMT) is one efficient approach to improve functional recovery after ischemic stroke. The underlying molecular mechanism remains unclear. In the current study, we investigated the effects of CIMT on angiogenesis and neurogenesis. To start linking our findings to molecular mediators, we further examined the expression of hypoxia-inducible factor-1α (HIF-1α), factor inhibiting HIF-1 (FIH-1) and vascular endothelial growth factor (VEGF)...
November 28, 2017: Current Neurovascular Research
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