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https://www.readbyqxmd.com/read/28531227/different-microrna-profiles-reveal-the-diverse-outcomes-induced-by-ev71-and-ca16-infection-in-human-umbilical-vein-endothelial-cells-using-high-throughput-sequencing
#1
Jie Song, Yajie Hu, Jiaqi Li, Huiwen Zheng, Jingjing Wang, Lei Guo, Ruotong Ning, Hongzhe Li, Zening Yang, Haitao Fan, Longding Liu
Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) remain the predominant pathogens in hand, foot, and mouth disease (HFMD), but the factors underlying the pathogenesis of EV71 and CA16 infections have not been elucidated. Recently, the functions of microRNAs (miRNAs) in pathogen-host interactions have been highlighted. In the present study, we performed comprehensive miRNA profiling in EV71- and CA16-infected human umbilical vein endothelial cells (HUVECs) at multiple time points using high-throughput sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28527835/biomechanical-study-on-surgical-fixation-methods-for-minimally-invasive-treatment-of-hallux-valgus
#2
Rui Mao, Junchao Guo, Chenyu Luo, Yubo Fan, Jianmin Wen, Lizhen Wang
Hallux valgus (HV) was one of the most frequent female foot deformities. The aim of this study was to evaluate mechanical responses and stabilities of the Kirschner, bandage and fiberglass fixations after the distal metatarsal osteotomy in HV treatment. Surface traction of different forefoot regions in bandage fixation and the biomechanical behavior of fiberglass bandage material were measured by a pressure sensor device and a mechanical testing, respectively. A three-dimensional foot finite element (FE) model was developed to simulate the three fixation methods (Kirschner, bandage and fiberglass fixations) in weight bearing...
May 17, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28526612/histomorphological-observation-of-surgical-debridement-combined-with-negative-pressure-therapy-in-treatment-of-diabetic-foot
#3
Jiao-Yun Dong, Fei Song, Chun Qing, Shu-Liang Lu
PURPOSE: To further study the mechanism of epithelization on the fascia side of the flap after surgical incision and the treatment of the negative pressure therapy. METHODS: With the patients' informed consent, parts of tissue samples were obtained from a 51-year-old diabetic patient who was suffering lower extremity ulcers. The samples were processed with hematoxylin and eosin (HE) staining and Masson trichrome staining. The keratin 19, keratin 15 and carcino-embryonic antigen (CEA) were immunohistochemically detected...
April 20, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28525946/ghrelin-attenuates-vascular-calcification-in-diabetic-patients-with-amputation
#4
Suining Xu, Fei Ye, Lihua Li, Jinchuan Yan, Zhengyang Bao, Zhen Sun, Liangjie Xu, Jie Zhu, Zhongqun Wang
Vascular calcification is established to be a critical factor in diabetes mellitus, which causes cardiovascular and amputation complication of diabetic patients. OPG/RANKL/RANK axis serves as a regulatory role in vascular calcification. Ghrelin, an endogenous ligand of growth hormone secretagogue receptor (GHSR), has been reported to exhibit potent cardiovascular protective effects. However, the role of ghrelin in the regulation of diabetic vascular calcification is still elusive. Here, we reported the role of ghrelin and its relationship with OPG/RANKL/RANK system in patients with diabetic foot amputation...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28522185/orofacial-complex-regional-pain-syndrome-pathophysiologic-mechanisms-and-functional-mri
#5
Yeon-Hee Lee, Kyung Mi Lee, Hyug-Gi Kim, Soo-Kyung Kang, Q-Schick Auh, Jyung-Pyo Hong, Yang-Hyun Chun
Complex regional pain syndrome (CRPS) is one of the most challenging chronic pain conditions and is characterized by burning pain, allodynia, hyperalgesia, autonomic changes, trophic changes, edema, and functional loss involving mainly the extremities. Until recently, very few reports have been published concerning CRPS involving the orofacial area. We report on a 50-year-old female patient who presented with unbearable pain in all of her teeth and hypersensitivity of the facial skin. She also reported intractable pain in both extremities accompanied by temperature changes and orofacial pain that increased when the other pains were aggravated...
March 14, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28520756/de-novo-assembly-and-comparative-transcriptome-analysis-of-the-foot-from-chinese-green-mussel-perna-viridis-in-response-to-cadmium-stimulation
#6
Xinhui Zhang, Zhiqiang Ruan, Xinxin You, Jintu Wang, Jieming Chen, Chao Peng, Qiong Shi
The Chinese green mussel, Perna viridis, is a marine bivalve with important economic values as well as biomonitoring roles for aquatic pollution. Byssus, secreted by the foot gland, has been proved to bind heavy metals effectively. In this study, using the RNA sequencing technology, we performed comparative transcriptomic analysis on the mussel feet with or without inducing by cadmium (Cd). Our current work is aiming at providing insights into the molecular mechanisms of byssus binding to heavy metal ions. The transcriptome sequencing generated a total of 26...
2017: PloS One
https://www.readbyqxmd.com/read/28515727/basics-of-radiation-biology-when-treating-hyperproliferative-benign-diseases
#7
REVIEW
Franz Rödel, Claudia Fournier, Julia Wiedemann, Felicitas Merz, Udo S Gaipl, Benjamin Frey, Ludwig Keilholz, M Heinrich Seegenschmiedt, Claus Rödel, Stephanie Hehlgans
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28505302/the-first-whole-genome-and-transcriptome-of-the-manila-clam-ruditapes-philippinarum-isolated-in-korea
#8
Seyoung Mun, Yun-Ji Kim, Kesavan Markkandan, Wonseok Shin, Sumin Oh, Jiyoung Woo, Jongsu Yoo, Hyesuck An, Kyudong Han
The manila clam, Ruditapes philippinarum, is an important bivalve species in worldwide aquaculture including Korea. The aquaculture production of R. philippinarum is under threat from diverse environmental factors including viruses, microorganisms, parasites, and water conditions with subsequently declining production. In spite of its importance as a marine resource, the reference genome of R. philippinarum for comprehensive genetic studies is largely unexplored. Here, we report the de novo whole-genome and transcriptome assembly of R...
May 13, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28502979/chrysin-ameliorates-podocyte-injury-and-slit-diaphragm-protein-loss-via-inhibition-of-the-perk-eif2%C3%AE-atf-chop-pathway-in-diabetic-mice
#9
Min-Kyung Kang, Sin-Hye Park, Yun-Ho Kim, Eun-Jung Lee, Lucia Dwi Antika, Dong Yeon Kim, Yean-Jung Choi, Young-Hee Kang
Glomerular epithelial podocytes are highly specialized cells that play a crucial role in maintaining normal function of the glomerular filtration barrier via their foot processes. Chrysin (5,7-dihydroxyflavone) is a natural flavonoid found in propolis and mushrooms that has anti-inflammatory, antioxidant and anticancer properties. This study aimed to evaluate the renoprotective effects of chrysin on podocyte apoptotic loss and slit diaphragm protein deficiency in high glucose-exposed podocytes and in db/db mouse kidneys...
May 15, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28501992/personalized-medicine-ethical-aspects
#10
G Terry Sharrer
In our time of genome-based personalized medicine, clinical research and clinical medicine are accelerating at a quick pace. Faster and cheaper DNA sequencing and protein profiling, microfluidic devices for capturing blood biomarkers, nanoparticles for precise drug delivery and enhanced imaging, rapid computational analysis of massive data inputs, and other technological wonders coalesce to create a kind of Moore's Law for medicine. Needs are obvious, knowledge grows, capital becomes available, but these factors are not entirely sufficient to make health more achievable...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28501788/dynamic-femoral-head-translations-in-dysplastic-hips
#11
Tatsuya Sato, Hiromasa Tanino, Yasuhiro Nishida, Hiroshi Ito, Takeo Matsuno, Scott A Banks
BACKGROUND: Developmental dysplasia of the hip is an important disease leading to osteoarthritis. Recently, researchers have focused on hip instability as a potentially important dynamic factor for osteoarthritis, but the detailed kinematics of dysplastic hips during weight-bearing gait have not been reported. The purpose of this research is to contrast femoral translation in contralateral healthy hips and dysplastic hips during weight-bearing stepping. METHODS: Twelve dysplastic hips and eight healthy hips were investigated...
May 5, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28501303/potential-relevance-of-shear-stress-for-slit-diaphragm-and-podocyte-function
#12
Wilhelm Kriz, Kevin V Lemley
Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit.
June 2017: Kidney International
https://www.readbyqxmd.com/read/28499159/sensitivity-of-biomechanical-outcomes-to-independent-variations-of-hindfoot-and-forefoot-stiffness-in-foot-prostheses
#13
Peter Gabriel Adamczyk, Michelle Roland, Michael E Hahn
Many studies have reported the effects of different foot prostheses on gait, but most results cannot be generalized because the prostheses' properties are seldom reported. We varied hindfoot and forefoot stiffness in an experimental foot prosthesis, in increments of 15N/mm, and tested the parametric effects of these variations on treadmill walking in unilateral transtibial amputees, at speeds from 0.7 to 1.5m/s. We computed outcomes such as prosthesis energy return, center of mass (COM) mechanics, ground reaction forces, and joint mechanics, and computed their sensitivity to component stiffness...
May 9, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28495401/transcriptomic-analysis-of-porcine-pbmcs-in-response-to-fmdv-infection
#14
Fu-Rong Zhao, Yin-Li Xie, Ze-Zhong Liu, Jun-Jun Shao, Shi-Fang Li, Peng Zhou, Yong-Guang Zhang, Hui-Yun Chang
Foot-and-mouth disease (FMD) is a significant zoonotic infectious disease. It has an important economic impact throughout the world. As well, it is a considerable threat to food security. At present, the molecular mechanism of FMDV infection is not clear to a large extent. Innate immune response is the first line of defense against infectious diseases. The systematic analysis of the host immune response to infection has an important role in understanding the pathogenesis of infection. However, there are few reports about effect of immune regulation on virus replication in the interaction of virus and host cellular...
May 8, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28494322/constituent-lower-extremity-work-clew-approach-a-novel-tool-to-visualize-joint-and-segment-work
#15
Anahid Ebrahimi, Saryn R Goldberg, Jason M Wilken, Steven J Stanhope
Work can reveal the mechanism by which movements occur. However, work is less physically intuitive than more common clinical variables such as joint angles, and are scalar quantities which do not have a direction. Therefore, there is a need for a clearly reported and comprehensively calculated approach to easily visualize and facilitate the interpretation of work variables in a clinical setting. We propose the Constituent Lower Extremity Work (CLEW) approach, a general methodology to visualize and interpret cyclic tasks performed by the lower limbs...
April 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28491036/pharmacological-activity-and-clinical-use-of-pdrn
#16
REVIEW
Francesco Squadrito, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Letteria Minutoli, Domenica Altavilla
PDRN is a proprietary and registered drug that possesses several activities: tissue repairing, anti-ischemic, and anti-inflammatory. These therapeutic properties suggest its use in regenerative medicine and in diabetic foot ulcers. PDRN holds a mixture of deoxyribonucleotides with molecular weights ranging between 50 and 1,500 KDa, it is derived from a controlled purification and sterilization process of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon) sperm DNA. The procedure guarantees the absence of active protein and peptides that may cause immune reactions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28490695/-effect-of-hydrogen-sulfide-on-inducible-nitric-oxide-synthase-in-kidneys-of-type-1-diabetic-rats
#17
Rui Yang, Qiang Jia, Shanfeng Ma, Shujun Cui, Xiaofen Liu, Yuanyuan Wang, Qin Gao
To investigate effects of hydrogen sulfide (H2S) on inducible nitric oxide synthase (iNOS) in kidneys of Type 1 diabetic rats.
 Methods: Thirty-two male SD rats were randomly divided into four groups: A normal control (NC) group, a diabetes mellitus (DM) group, a NaHS (NaHS+DM) group, and a NaHS control (NaHS) group (n=8 per group). Type 1 diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg). After successful establishment of models, the rats in NaHS+DM and NaHS groups were injected with NaHS solution (56 μmol/kg) intraperitoneally...
April 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28489374/theoretical-study-of-the-pair-correlated-f-chd3-v-0-%C3%AE-1-1-reaction-effect-of-ch-stretching-vibrational-excitation
#18
Joaquin Espinosa-Garcia, Laurent Bonnet, Jose Carlos Corchado
The F + CHD3(v) reaction is a benchmark system in polyatomic reactions. Theoretical/experimental comparisons have been reported in recent years which present some controversies, specifically the role of the reactant CH stretching vibrational excitation, CHD3(v1=1), on the reactivity of both isotope channels, DF(v) + CHD2(v´) and HF(v) + CD3(v´). However, in many cases these comparisons are not made on an equal footing. Previous theoretical studies were concerned with overall reactivity of each isotope channel, while fine velocity map imaging experiments provided results in a product pair-correlated manner...
May 10, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28487621/effect-of-drop-foot-on-spatiotemporal-kinematic-and-kinetic-parameters-during-gait
#19
Ida Wiszomirska, Michalina Błażkiewicz, Katarzyna Kaczmarczyk, Grażyna Brzuszkiewicz-Kuźmicka, Andrzej Wit
Background. The complexity of the structure and function of a living body can be affected by disorders and can cause various dysfunctions. Objective. The aim of this study was to determine compensatory mechanisms in subjects with drop foot during gait. Methods. The study evaluated 10 subjects with drop foot (DF) whose results were compared to a group of 10 healthy controls (C). Spatiotemporal, kinematic, and kinetic parameters during the gait cycle were collected using Vicon system synchronized with Kistler platforms...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/28486847/the-effects-of-common-footwear-on-stance-phase-mechanical-properties-of-the-prosthetic-foot-shoe-system
#20
Matthew J Major, Joel Scham, Michael Orendurff
BACKGROUND: Prosthetic feet are prescribed based on their mechanical function and user functional level. Subtle changes to the stiffness and hysteresis of heel, midfoot, and forefoot regions can influence the dynamics and economy of gait in prosthesis users. However, the user's choice of shoes may alter the prosthetic foot-shoe system mechanical characteristics, compromising carefully prescribed and rigorously engineered performance of feet. OBJECTIVES: Observe the effects of footwear on the mechanical properties of the prosthetic foot-shoe system including commonly prescribed prosthetic feet...
May 1, 2017: Prosthetics and Orthotics International
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