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https://www.readbyqxmd.com/read/29678443/high-frequency-stimulation-of-the-infralimbic-cortex-following-behavioral-suppression-of-ptsd-like-symptoms-prevents-symptom-relapse-in-mice
#1
Yassine Bentefour, Mohamed Bennis, René Garcia, Saadia Ba-M'hamed
BACKGROUND: We have previously demonstrated, in mice, that antidepressant treatment can prevent relapse of PTSD-like behaviors (avoidance, hyperarousal, and anxiety) through increased activation in the infralimbic cortex (IL) of the medial prefrontal cortex. OBJECTIVE: Here, we examined whether direct high-frequency stimulation (HFS) of the IL, provoking its heightened activation (i.e., long-term potentiation, LTP), would also prevent the return of PTSD-like symptoms...
April 10, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29677125/detrimental-effects-of-helium-ion-irradiation-on-cognitive-performance-and-cortical-levels-of-map-2-in-b6d2f1-mice
#2
Jacob Raber, Eileen Ruth S Torres, Tunde Akinyeke, Joanne Lee, Sydney J Weber Boutros, Mitchell S Turker, Amy Kronenberg
The space radiation environment includes helium (⁴He) ions that may impact brain function. As little is known about the effects of exposures to ⁴He ions on the brain, we assessed the behavioral and cognitive performance of C57BL/6J × DBA2/J F1 (B6D2F1) mice three months following irradiation with ⁴He ions (250 MeV/n; linear energy transfer (LET) = 1.6 keV/μm; 0, 21, 42 or 168 cGy). Sham-irradiated mice and mice irradiated with 21 or 168 cGy showed novel object recognition, but mice irradiated with 42 cGy did not...
April 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29675902/demography-or-selection-on-linked-cultural-traits-or-genes-investigating-the-driver-of-low-mtdna-diversity-in-the-sperm-whale-using-complementary-mitochondrial-and-nuclear-genome-analyses
#3
Phillip A Morin, Andrew D Foote, C Scott Baker, Brittany L Hancock-Hanser, Kristin Kaschner, Bruce R Mate, Sarah L Mesnick, Victoria L Pease, Patricia E Rosel, Alana Alexander
Mitochondrial DNA has been heavily utilized in phylogeography studies for several decades. However, underlying patterns of demography and phylogeography may be misrepresented due to coalescence stochasticity, selection, variation in mutation rates, and cultural hitchhiking (linkage of genetic variation to culturally transmitted traits affecting fitness). Cultural hitchhiking has been suggested as an explanation for low genetic diversity in species with strong social structures, counteracting even high mobility, abundance and limited barriers to dispersal...
April 19, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29673934/foot-structure-and-knee-joint-kinetics-during-walking-with-and-without-wedged-footwear-insoles
#4
Ryan T Lewinson, Ryan Madden, Anthony Killick, John W Wannop, J Preston Wiley, Victor M Y Lun, Chirag Patel, Jeremy M LaMothe, Darren J Stefanyshyn
The relationship between static foot structure characteristics and knee joint biomechanics during walking, or the biomechanical response to wedged insoles are currently unknown. In this study, 3D foot scanning, dual X-ray absorptiometry and gait analysis methods were used to determine structural parameters of the foot and assess their relation to knee joint loading and biomechanical response to wedged insoles in 30 patients with knee osteoarthritis. In multiple linear regression models, foot fat content, height of the medial longitudinal arch and static hind foot angle were not associated with the magnitude of the knee adduction moment (R2  = 0...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29673221/key-processes-of-silicon-on-glass-mems-fabrication-technology-for-gyroscope-application
#5
Zhibo Ma, Yinan Wang, Qiang Shen, Han Zhang, Xuetao Guo
MEMS fabrication that is based on the silicon-on-glass (SOG) process requires many steps, including patterning, anodic bonding, deep reactive ion etching (DRIE), and chemical mechanical polishing (CMP). The effects of the process parameters of CMP and DRIE are investigated in this study. The process parameters of CMP, such as abrasive size, load pressure, and pH value of SF1 solution are examined to optimize the total thickness variation in the structure and the surface quality. The ratio of etching and passivation cycle time and the process pressure are also adjusted to achieve satisfactory performance during DRIE...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29669318/neurod-expression-in-podocytes-and-interrelationships-with-nephrin-at-both-nuclear-and-cytoplasmic-sites
#6
Silvia Armelloni, Masami Ikehata, Deborah Mattinzoli, Min Li, Carlo Maria Alfieri, Mariapia Rastaldi, Piergiorgio Messa
Background/Aims The research of genes implicated in kidney glomerular function, eliciting cell fate program, is always at the forefront in nephrological studies. Several neurological molecules have been recently the object of study not only for their involvement in the central nervous system differentiation but also for their importance in the functionality of other organs and for mature phenotype, as in kidney. NeuroD, in CNS, is related to two functional roles, the early survival and the differentiation. The aim of our study was to ascertain the presence of NeuroD transcription factor in glomeruli and to understand which targets and mechanisms NeuroD controls...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29666760/barefoot-running-does-not-affect-simple-reaction-time-an-exploratory-study
#7
Nicholas J Snow, Jason F L Blair, Graham Z MacDonald, Jeannette M Byrne, Fabien A Basset
Background: Converging evidence comparing barefoot (BF) and shod (SH) running highlights differences in foot-strike patterns and somatosensory feedback, among others. Anecdotal evidence from SH runners attempting BF running suggests a greater attentional demand may be experienced during BF running. However, little work to date has examined whether there is an attentional cost of BF versus SH running. Objective: This exploratory study aimed to examine whether an acute bout of BF running would impact simple reaction time (SRT) compared to SH running, in a sample of runners naïve to BF running...
2018: PeerJ
https://www.readbyqxmd.com/read/29661094/an-investigation-of-pik3ca-mutations-in-isolated-macrodactyly
#8
Jingheng Wu, Wei Tian, Guanglei Tian, Kelli Sumner, Douglas T Hutchinson, Yuan Ji
Somatic PIK3CA mutations may relate to pathogenesis of isolated macrodactyly. We set up to test the association between PIK3CA mutations with isolated macrodactyly in order to establish a more accurate and molecular mechanism-based diagnosis and classification. DNA extracted from affected tissues in 12 individuals with isolated macrodactyly was tested for PIK3CA mutation using targeted Sanger DNA sequencing. Ten patients had macrodactyly in the foot and two in the hand. Nine of the 12 patients were found to carry a low-level, mosaic PIK3CA mutation...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29658814/combined-spring-and-deltoid-ligament-repair-in-adult-acquired-flatfoot
#9
Caio Nery, André Vitor Kerber C Lemos, Fernando Raduan, Nacime Salomão B Mansur, Daniel Baumfeld
BACKGROUND: Adult-acquired flatfoot deformity (AAFD) is usually due to a combination of mechanical failure of the osteoligamentous complex that maintains the medial longitudinal arch of the foot and attenuation or complete tear of the posterior tibial tendon. Magnetic resonance imaging studies in patients with flatfoot deformities have reported the posterior tibial tendon to be pathologic in up to 100% of patients, the spring ligament in up to 87%, and the deltoid ligament in 33%. Many studies in the literature describe reconstruction of the spring ligament or the deltoid ligament associated with AAFD, but there is no study in which both (spring and deltoid) ligaments are reconstructed at the same time...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29658528/gait-changes-in-patients-after-reconstruction-of-facial-bones-with-fibula-and-iliac-crest-free-vascularized-flaps
#10
Małgorzata Syczewska, Romuald Krajewski, Monika Kirwil, Ewa Szczerbik, Małgorzata Kalinowska
PURPOSE: Patients with malignant tumours of the oral cavity require its surgical removal and reconstruction of the bone and soft tissues. The grafts are obtained either from leg (fibula) or pelvis (iliac crest). The removal of grafts from the locomotor apparatus can impair the gait. The aim of this study was to find out how the localization of donor site influences the gait pattern. METHODS: Results obtained for 30 patients were analyzed (16 fibula graft, 14 iliac crest graft)...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29657849/talar-process-fractures-an-overview-and-update-of-the-literature
#11
Haroon Majeed, Donald J McBride
Fractures of the lateral and the posterior processes of the talus are uncommon and frequently missed because of a low level of suspicion and difficulty in interpretation on plain radiographs. Missed fractures can lead to persistent pain and reduced function.Lateral process fractures are usually a consequence of forced dorsiflexion and inversion of fixed pronated foot. These are also commonly known as snowboarder's fractures.The posterior process of the talus is composed of medial and lateral tubercles, separated by the groove for the flexor hallucis longus tendon...
March 2018: EFORT Open Reviews
https://www.readbyqxmd.com/read/29657819/substrate-texture-affects-female-cricket-walking-response-to-male-calling-song
#12
E J Sarmiento-Ponce, M P F Sutcliffe, B Hedwig
Field crickets are extensively used as a model organism to study female phonotactic walking behaviour, i.e. their attraction to the male calling song. Laboratory-based phonotaxis experiments generally rely on arena or trackball-based settings; however, no attention has been paid to the effect of substrate texture on the response. Here, we tested phonotaxis in female Gryllus bimaculatus , walking on trackballs machined from methyl-methacrylate foam with different cell sizes. Surface height variations of the trackballs, due to the cellular composition of the material, were measured with profilometry and characterized as smooth, medium or rough, with roughness amplitudes of 7...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29649932/optimal-tube-length-of-orotracheal-intubation-for-mice
#13
Nobuyuki Nosaka, Timothy R Crother, Shuang Chen, Moshe Arditi, Kenichi Shimada
Endotracheal tube (ETT) management is an essential technique in handling mice with mechanical ventilators. Malposition into bronchi causes not only lethal complications for them but also less efficient mechanical ventilation. However, in general, it is difficult to know whether the ETT is placed with appropriate depth into the trachea of mice. We measured the distance from incisors to the bifurcation of trachea of multiple mice, and created a new estimation formula to obtain the suitable ETT length for mice with a body weight range from 17 g to 25 g: length (mm) = 0...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29645277/insights-to-plant-microbe-interactions-provide-opportunities-to-improve-resistance-breeding-against-root-diseases-in-grain-legumes
#14
Lukas Wille, Monika M Messmer, Bruno Studer, Pierre Hohmann
Root and foot diseases severely impede grain legume cultivation worldwide. Breeding lines with resistance against individual pathogens exist, but these resistances are often overcome by the interaction of multiple pathogens in field situations. Novel tools allow to decipher plant-microbiome interactions in unprecedented detail and provide insights into resistance mechanisms that consider both simultaneous attacks of various pathogens and the interplay with beneficial microbes. Although it has become clear that plant-associated microbes play a key role in plant health, a systematic picture of how and to what extend plants can shape their own detrimental or beneficial microbiome remains to be drawn...
April 12, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29626210/the-life-cycle-of-non-polio-enteroviruses-and-how-to-target-it
#15
REVIEW
Jim Baggen, Hendrik Jan Thibaut, Jeroen R P M Strating, Frank J M van Kuppeveld
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus, coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse viruses cause a variety of diseases, including non-specific febrile illness, hand-foot-and-mouth disease, neonatal sepsis-like disease, encephalitis, paralysis and respiratory diseases. In recent years, several non-polio enteroviruses (NPEVs) have emerged as serious public health concerns. These include EV-A71, which has caused epidemics of hand-foot-and-mouth disease in Southeast Asia, and EV-D68, which recently caused a large outbreak of severe lower respiratory tract disease in North America...
April 6, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29623811/assessment-of-the-compressive-and-tensile-mechanical-properties-of-materials-used-in-the-jaipur-foot-prosthesis
#16
Rachel H Teater, Kristine M Fischenich, Benjamin B Wheatley, Lisa Abrams, Sheryl A Sorby, Harlal Singh Mali, Anil Jain, Tammy L Haut Donahue
BACKGROUND: Designed by Dr. Sethi, the Jaipur Foot prosthesis is ideally suited for amputees in developing countries as it utilizes locally sourced, biodegradable, inexpensive materials and is focused on affordability and functionality. To date, however, no data have been reported on the material properties of the foot components. OBJECTIVES: The goal of this work was to evaluate mechanical properties of the Jaipur Foot components to guide foot design and manufacturing and reduce weight...
April 1, 2018: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/29617149/effect-of-surgical-weight-loss-on-plantar-fasciitis-and-healthcare-utilization
#17
Mena Boules, Esam Batayyah, Dvir Froylich, Andrea Zelisko, Colin O'Rourke, Stacy Brethauer, Kevin El-Hayek, Allan Boike, Andrew Strong, Matthew Kroh
BACKGROUND: Plantar fasciitis (PF) is known to be one of the most common causes of heel pain. Obesity is recognized as a significant factor in PF development, possibly due to increased mechanical loading of the foot as a result of excess weight. The benefit of bariatric surgery is documented for other comorbidities but not for PF. METHODS: Retrospective chart review of patients with a diagnosis of PF identified from a prospectively maintained database of the Cleveland Clinic Bariatric and Metabolic Institute...
April 4, 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29609157/acute-and-mid-term-six-week-effects-of-an-ankle-foot-orthosis-on-biomechanical-parameters-clinical-outcomes-and-physical-activity-in-knee-osteoarthritis-patients-with-varus-malalignment
#18
Maik Sliepen, Elsa Mauricio, Dieter Rosenbaum
BACKGROUND: Knee osteoarthritis (KOA) is a painful disease commonly caused by high loads on the articular cartilage. Orthotic interventions aim to reduce mechanical loading, thereby alleviating pain. Traditional orthotics appear effective, but high drop-out rates have been reported over prolonged periods. RESEARCH QUESTION: The aim of this study was to examine the effect of a novel ankle-foot orthosis (AFO) on gait parameters, physical function and activity of KOA patients...
March 26, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29603282/sequence-analysis-based-characterization-and-identification-of-neurovirulence-associated-variants-of-36-ev71-strains-from-china
#19
Jun Xu, Fang Wang, Desheng Zhao, Jiang Liu, Hong Su, Baolong Wang
Enterovirus 71 (EV71) is the main pathogen of hand-foot-mouth disease (HFMD) and causes several neurological complications. As new strains of EV71 are constantly discovered, it is important to understand the genomic characteristics of the viruses and the mechanism of virulence. Herein, we isolated five strains of EV71 from HFMD patients with or without neurovirulence and sequenced their whole genomes. We then performed whole genome sequence analysis of totally 36 EV71 strains. The phylogenetic analysis of the VP1 region revealed all five isolated strains are clustered into C4a of C4 subgenotype...
March 30, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29599517/increasing-prosthetic-foot-energy-return-affects-whole-body-mechanics-during-walking-on-level-ground-and-slopes
#20
W Lee Childers, Kota Z Takahashi
Prosthetic feet are designed to store energy during early stance and then release a portion of that energy during late stance. The usefulness of providing more energy return depends on whether or not that energy transfers up the lower limb to aid in whole body propulsion. This research examined how increasing prosthetic foot energy return affected walking mechanics across various slopes. Five people with a uni-lateral transtibial amputation walked on an instrumented treadmill at 1.1 m/s for three conditions (level ground, +7...
March 29, 2018: Scientific Reports
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