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Anne M Boonstra, Roy E Stewart, Albère J A Köke, René F A Oosterwijk, Jeannette L Swaan, Karlein M G Schreurs, Henrica R Schiphorst Preuper
Objectives: The 0-10 Numeric Rating Scale (NRS) is often used in pain management. The aims of our study were to determine the cut-off points for mild, moderate, and severe pain in terms of pain-related interference with functioning in patients with chronic musculoskeletal pain, to measure the variability of the optimal cut-off points, and to determine the influence of patients' catastrophizing and their sex on these cut-off points. Methods: 2854 patients were included. Pain was assessed by the NRS, functioning by the Pain Disability Index (PDI) and catastrophizing by the Pain Catastrophizing Scale (PCS)...
2016: Frontiers in Psychology
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using Poly Lactic-co-Glycolic Acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However the route of internalisation of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterised glutathione- functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
October 15, 2016: Molecular Pharmaceutics
Nazende Günday Türeli, Akif Emre Türeli, Marc Schneider
Design of Experiments (DoE) is a powerful tool for systematic evaluation of process parameters' effect on nanoparticle (NP) quality with minimum number of experiments. DoE was employed for optimization of ciprofloxacin loaded PLGA NPs for pulmonary delivery against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lungs. Since the biofilm produced by bacteria was shown to be a complicated 3D barrier with heterogeneous meshes ranging from 100nm to 500 nm, nanoformulations small enough to travel through those channels were assigned as target quality...
October 12, 2016: International Journal of Pharmaceutics
Brett T Doherty, Stephanie M Engel, Jessie P Buckley, Manori J Silva, Antonia M Calafat, Mary S Wolff
INTRODUCTION: Evidence suggests prenatal phthalate exposures may have neurodevelopmental consequences. Our objective was to investigate prenatal exposure to phthalates and cognitive development in a cohort of young urban children. MATERIALS AND METHODS: We recruited pregnant women in New York City from 1998 to 2002 and measured concentrations of nine phthalate metabolites in urine collected in late pregnancy. We administered a neurodevelopmental screening instrument, the Bayley Scales of Infant Development II (BSID-II), to children who returned for follow-up at approximately 24 months (n=276)...
October 11, 2016: Environmental Research
Tadao Takada, Misa Ido, Akane Ashida, Mitsunobu Nakamura, Kazushige Yamana
DNA is considered to be a promising biomolecule as a template and scaffold for arranging and organizing functional molecules on the nanoscale. The construction and evaluation of DNAs containing multiple functional molecules that are useful for optoelectronic devices and sensors has been studied. In this paper we report the efficient incorporation of perylenediimide (PDI) units into DNA by using abasic sites both as binding sites and as reactive sites and the construction of PDI stacks within the DNA structure, accomplished through the preorganization of the PDI units in the hydrophobic pocket within the DNA...
October 14, 2016: Chembiochem: a European Journal of Chemical Biology
Chao Wang, François N Miros, Jiri Mareda, Naomi Sakai, Stefan Matile
Anion-π catalysis, that is the stabilization of anionic transition states on π-acidic aromatic surfaces, has so far been developed with naphthalenediimides (NDIs). This report introduces perylenediimides (PDIs) to anion-π catalysis. The quadrupole moment of PDIs (+23.2 B) is found to exceed that of NDIs and reach new records with acceptors in the core (+70.9 B), and their larger surface provides space to better accommodate chemical transformations. Unlike NDIs, the activity of PDI catalysts for enolate and enamine addition is determined by the twist of their π surface rather than their reducibility...
October 14, 2016: Angewandte Chemie
H T Black, N Yee, Y Zems, D F Perepichka
A comprehensive investigation of the complementary H-bonding-mediated self-assembly between dipyrrolo[2,3-b:3',2'-e]pyridine (P2P) electron donors and naphthalenediimide/perylenediimide (NDI/PDI) acceptors is reported. The synthesis of parent P2P and several aryl-substituted derivatives is described, along with their optical, redox, and single-crystal packing characteristics. The dual functionality of heteroatoms in the P2P/NDI(PDI) assembly, which act as proton donors/acceptors and also contribute to π-conjugation, leads to H-bonding-induced perturbation of electronic levels...
October 14, 2016: Chemistry: a European Journal
C Liu, M Hu, B Zhang, X Zeng
BACKGROUND: The use of photodynamic antimicrobial chemotherapy (PACT) to treat localized Candida infections is an emerging and promising therapeutic approach. AIM: To assess the photodynamic inactivation (PDI) efficacy of haematoporphyrin monomethyl ether (HMME) on the biofilms produced by standard (ATCC 10231) and fluconazole-resistant Candida albicans strains. METHODS: The PDI efficacy was evaluated by incubating C. albicans biofilms with 0...
October 13, 2016: Clinical and Experimental Dermatology
Martin Streiter, Stefan Krause, Christian von Borczyskowski, Carsten Deibel
We report on time dependent Stokes shift measurements of single molecules. Broadband excitation and emission spectroscopy were applied to study the temporal Stokes shift evolution of single perylene diimide molecules (PDI) embedded in a polymer matrix on the time scale of seconds. The Stokes shift varied between individual molecules as well as for single molecules undergoing different conformations and geometries. From the distribution and temporal evolution of Stokes shifts, we unravel the interplay of nano-environment and molecular conformation...
October 12, 2016: Journal of Physical Chemistry Letters
John J Kiernicki, Maryline G Ferrier, Juan S Lezama Pacheco, Henry S La Pierre, Benjamin W Stein, Matthias Zeller, Stosh A Kozimor, Suzanne C Bart
Arylazide and diazene activation by highly reduced uranium(IV) complexes bearing trianionic redox-active pyridine(diimine) ligands, [Cp(P)U((Mes)PDI(Me))]2 (1-Cp(P)), Cp*U((Mes)PDI(Me))(THF) (1-Cp*) (Cp(P) = 1-(7,7-dimethylbenzyl)cyclopentadienide; Cp* = η(5)-1,2,3,4,5-pentamethylcyclopentadienide), and Cp*U((t)Bu-(Mes)PDI(Me)) (THF) (1-(t)Bu) (2,6-((Mes)N═CMe)2-p-R-C5H2N, Mes = 2,4,6-trimethylphenyl; R = H, (Mes)PDI(Me); R = C(CH3)3, (t)Bu-(Mes)PDI(Me)), has been investigated. While 1-Cp* and 1-Cp(P) readily reduce N3R (R = Ph, p-tolyl) to form trans-bis(imido) species, Cp(P)U(NAr)2((Mes)PDI(Me)) (Ar = Ph, 2-Cp(P); Ar = p-Tol, 3-Cp(P)) and Cp*U(NPh)2((Mes)PDI(Me)) (2-Cp*), only 1-Cp* can cleave diazene N═N double bonds to form the same product...
October 12, 2016: Journal of the American Chemical Society
Nathaniel J Schuster, Daniel W Paley, Steffen Jockusch, Fay Ng, Michael L Steigerwald, Colin Nuckolls
We report two new helicenes derived from the double fusion of an acene with two perylene diimide (PDI) subunits. These PDI-helicene homologs exhibit very different structural and electronic properties, despite differing by only a single ring in the link between the PDI units. The shorter inter-PDI link brings the two PDI subunits closer together, and this results in the collision of their respective π-electron clouds. This collision facilitates intramolecular through-space electronic delocalization when the PDI-helicene is reduced...
October 17, 2016: Angewandte Chemie
Nathalie Zink-Lorre, Enrique Font-Sanchis, Ángela Sastre-Santos, Fernando Fernández-Lázaro
Herein, we report a simple fluoride-mediated reaction for the direct mono- and dialkylthio-functionalization of unsubstituted perylenediimides (PDIs) under very mild conditions. The aromatic substitution reaction offers the possibility to introduce primary, secondary and, even, tertiary alkanethiols either on the 1- or on the 1,6-bay positions of unsubstituted PDIs. 1,6-DialkylthioPDIs show that absorption and fluorescence spectra shifted to the red when compared with the unsubstituted PDI, with Stokes shifts around 70-80 nm...
October 4, 2016: Organic & Biomolecular Chemistry
Chuanfen Pu, Wenting Tang
Contamination of Listeria monocytogenes in food and their processing environment is a focus of attention in the food industry. To achieve the controlled release of antibacterial agents to a food processing environment contaminated by L. monocytogenes, chitosan-stabilised liposomes encapsulating Apep10 (GLARCLAGTL), an antibacterial peptide derived from boiled-dried anchovies, were prepared by utilising listeria toxins to activate the peptide release. Characteristics including the particle size, polydispersity index (PDI), encapsulation efficiency (EE), and morphology of the chitosan-coated Apep10 liposomes were investigated...
October 12, 2016: Food & Function
Maha A Al-Mohaissen, Ronald G Carere, G B John Mancini, Karin H Humphries, Beth A Whalen, Terry Lee, Frank X Scheuermeyer, Andrew P Ignaszewski
BACKGROUND: Markers of plaque destabilization and disruption may have a role in identifying non-STE- type 1 Myocardial Infarction in patients presenting with troponin elevation. We hypothesized that a plaque disruption index (PDI) derived from multiple biomarkers and measured within 24 hours from the first detectable troponin in patients with acute non-STE- type 1 MI (NSTEMI-A) will confirm the diagnosis and identify these patients with higher specificity when compared to individual markers and coronary angiography...
2016: PloS One
B Etain, M Lajnef, F Bellivier, C Henry, K M'bailara, J P Kahn, M Leboyer, H L Fisher
BACKGROUND: Childhood trauma has been associated with a more severe clinical expression of bipolar disorder (BD). However, the results that specifically associated traumatic events and psychotic features in BD have been inconsistent, possibly due to the low resolution of the phenotypes being used. METHODS: 270 normothymic patients with BD completed the Childhood Trauma Questionnaire (CTQ) and the Peters Delusion Inventory (PDI) that assessed 21 delusional beliefs...
September 27, 2016: Journal of Psychiatric Research
Shingo Kanemura, Masaki Okumura, Katsuhide Yutani, Thomas Ramming, Takaaki Hikima, Christian Appenzeller-Herzog, Shuji Akiyama, Kenji Inaba
In the mammalian endoplasmic reticulum (ER), oxidoreductin-1α (Ero1α) generates protein disulfide bonds and transfers them specifically to canonical protein disulfide isomerase (PDI) to sustain oxidative protein folding. This oxidative process is coupled to the reduction of O2 to H2O2 on the bound flavin adenine dinucleotide (FAD) cofactor. Since excessive thiol oxidation and H2O2 generation cause cell death, Ero1α activity must be properly regulated. In addition to the four catalytic cysteines (Cys94, Cys99, Cys104 and Cys131) that are located in the flexible active site region, the Cys208-Cys241 pair located at the base of another flexible loop is necessary for Ero1α regulation, although the mechanistic basis is not fully understood...
October 4, 2016: Journal of Biological Chemistry
Tiantian Wu, Chunhua Wu, Shalu Fu, Liping Wang, Chunhong Yuan, Shiguo Chen, Yaqin Hu
Lysozyme was integrated into chitosan nanoparticles (CS-NPs) to improve the antibacterial activity. CS-NPs and chitosan-lysozyme nanoparticles (CS-Lys-NPs) were prepared according to the ionic gelation technique and then characterized by average size, zeta potential, polydispersity index (PDI), atomic force microscopy (AFM), fourier transform infrared (FT-IR), small-angle X-ray scattering (SAXS), circular dichroism (CD) and UV-visible spectroscopy. Antibacterial properties were investigated by transmission electron microscopy (TEM) based on observation of the inhibition zone and measurement of the minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) of CS-NPs and CS-Lys-NPs against E...
January 2, 2017: Carbohydrate Polymers
Faranak Dehghani, Nafiseh Farhadian, Shiva Golmohammadzadeh, Amir Biriaee, Mahmoud Ebrahimi, Mohammad Karimi
The aim of this study was to prepare and characterize a new nanocarrier for oral delivery of tamoxifen citrate (TMC) as a lipophilic oral administrated drug. This drug has low oral bioavailability due to its low aqueous solubility. To enhance the solubility of this drug, the microemulsion system was applied in form of oil-in-water. Sesame oil and Tween 80 were used as drug solvent oil and surfactant, respectively. Two different formulations were prepared for this purpose. The first formulation contained edible glycerin as co-surfactant and the second formulation contained Span 80 as a mixed surfactant...
September 27, 2016: European Journal of Pharmaceutical Sciences
Huimin Gao, Zhaoyu Chen, Yongmei Fu, Xiaoyan Yang, Ruihui Weng, Rui Wang, Jianjun Lu, Mengqiu Pan, Kunlin Jin, Chris McElroy, Beisha Tang, Ying Xia, Qing Wang
The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted in the 6-hydroxydopamine (OHDA)-lesioned PC12 cells to investigate the mechanisms underlying Nur77-mediated injury. The 6-OHDA incubation caused Nur77 translocation from the nucleus to cytosol and Endoplasm reticulum (ER) and induced co-localization of Tom20/Nur77 and Protein Disulfide Isomerase (PDI)/Nur77...
September 29, 2016: Scientific Reports
K Karzis, M Kalogeris, D Mandalidis, N Geladas, K Karteroliotis, S Athanasopoulos
The purpose of this study was to investigate Achilles tendon blood flow in individuals with overpronated feet during non-weight- and weight-bearing positions. Achilles tendon blood flow was measured by means of the pulsatility index (PI) and the resistance index (RI) in 15 male individuals with overpronated feet and 15 counterparts with normal feet, using power Doppler ultrasonography (PDI). Achilles tendon ultrasonographic (US) assessment was performed at its musculo-tendinous junction (MTJ), mid-tendon (MT), and osseotendinous junction (OTJ) at a non-weight-bearing relaxed position (RP) and during two-leg stance (TLS) and one-leg upright stance (OLS)...
September 27, 2016: Scandinavian Journal of Medicine & Science in Sports
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