keyword
MENU ▼
Read by QxMD icon Read
search

PDI

keyword
https://www.readbyqxmd.com/read/29165489/perylenediimide-based-glycoclusters-as-high-affinity-ligands-of-bacterial-lectins-synthesis-binding-studies-and-anti-adhesive-properties
#1
Marion Donnier-Maréchal, Nicolas Galanos, Teddy Grandjean, Yoann Pascal, Ding-Kun Ji, Lei Dong, Emilie Gillon, Xiao-Peng He, Anne Imberty, Eric Kipnis, Rodrigue Dessein, Sébastien Vidal
The synthesis of eight perylenediimide-based glycoclusters was readily performed from hexa- and tetra-propargylated cores through azide-alkyne "click" conjugation. Variations in the carbohydrate epitope (Glc, Gal, Man, Fuc) and the linker arm provided molecular diversity. Interactions with LecA and LecB, two proteins involved in the adhesion of Pseudomonas aeruginosa to host tissues, were evaluated by microcalorimetry (ITC). In both cases high affinities were obtained with Kd values in the nanomolar range. Further evaluation of their anti-adhesive properties using cultured epithelial cells demonstrated their potent anti-adhesive activities against Pseudomonas aeruginosa with only 30-40% residual adhesion observed...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29156350/photodynamic-inactivation-of-escherichia-coli-correlation-of-singlet-oxygen-kinetics-and-phototoxicity
#2
Alexander Müller, Annegret Preuß, Beate Röder
Photodynamic inactivation (PDI) of bacteria may play a major role in facing the challenge of the ever expanding antibiotic resistances. Here we report about the direct correlation of singlet oxygen luminescence kinetics and phototoxicity in E. coli cell suspension under PDI using the widely applied cationic photosensitizer TMPyP. Through direct access to the microenvironment, the time resolved investigation of singlet oxygen luminescence plays a key role in understanding the photosensitization mechanism and inactivation pathway...
November 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29154413/isoindigo-3-4-difluorothiophene-polymer-acceptors-yield-all-polymer-bhj-solar-cells-with-7-efficiency
#3
Shengjian Liu, Yuliar Firdaus, Simil Thomas, Zhipeng Kan, Federico Cruciani, Sergei Lopatin, Jean-Luc M Bredas, Pierre M Beaujuge
Poly(isoindigo-alt-3,4-difluorothiophene) (PIID[2F]T) analogues used as "polymer acceptors" in bulk-heterojunction (BHJ) solar cells achieve >7% efficiency when used in conjunction with the polymer donor PBFTAZ (model system). Considering that most efficient polymer acceptor alternatives to fullerenes (e.g. PC61BM or its C71 derivative) are based on perylenediimide (PDI) or naphthalenediimide (NDI) motifs thus far, branched alkyl-substituted PIID[2F]T polymers are remarkably promising nonfullerene candidates for "all-polymer" BHJ solar cells...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29151413/-effects-of-mechanical-ventilation-on-diaphragmatic-contractile-function-in-patients-with-aecopd
#4
Feifei Wang, Xiaoping Zhu, Changjing Zhang, Hui Zhu, Yu Feng, Yang Liu, Shaolin Ma
OBJECTIVE: To study diaphragmatic strength in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) during mechanical ventilation (MV), and to explore the predictive value of maximal transdiaphragm pressure (Pdi max) for successful extubation. METHODS: A prospective study was conducted. Twenty-one patients with AECOPD receiving MV admitted to intensive care unit (ICU) of Shanghai East Hospital of Tongji University of School Medicine from February 2015 to May 2017 were enrolled...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29149563/zein-nanoparticles-uptake-by-hydroponically-grown-soybean-plants
#5
Kurt Ristroph, Carlos E Astete, Ede Bodoki, Cristina M Sabliov
In the interest of developing and characterizing a polymeric nanoparticle pesticide delivery vehicle to soybeans, zein nanoparticle (ZNP) uptake by the roots and biodistribution to the leaves of soybean plants was measured. Zein was tagged with fluorescein isothiocyanate (FITC) and made into nanoparticles (135±3 nm diameter. 0.202±0.034 PDI and 81±4 mV zeta-potential at pH 6) using an emulsion-diffusion method. After ten days of hydroponic exposure, association between particles and roots of plants was found to vary based on bulk nanoparticle concentration...
November 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29148846/preparation-and-evaluation-of-curcumin-loaded-self-assembled-micelles
#6
Lu-Lu Wang, Dan-Dan He, Shu-Xia Wang, Yun-Hao Dai, Jian-Ming Ju, Cheng-Lei Zhao
Objective Curcumin being used to treat various chronic diseases while its poor bioavailability issue limited its wide clinical application as a therapeutic agent. The aim of this work was to prepare curcumin-loaded self-assembled micelles using soluplus and solutol®HS15 (SSCMs) to enhance curcumin's solubility and thus oral bioavailability. Methods Optimum formulation was investigated and the optimized ratio of drugs and excipients was obtained and the SSCMs were prepared via ethanol solvent evaporation method...
November 17, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29148715/ultrafast-long-range-charge-separation-in-nonfullerene-organic-solar-cells
#7
Yasunari Tamai, Yeli Fan, Vincent O Kim, Kostiantyn Ziabrev, Akshay Rao, Stephen Barlow, Seth R Marder, Richard H Friend, S Matthew Menke
Rapid, long-range charge separation in polymer-fullerene organic solar cells (OSCs) enables electrons and holes to move beyond their Coulomb capture radius and overcome geminate recombination. Understanding the nature of charge generation and recombination mechanisms in efficient, nonfullerene-acceptor-based OSCs are critical to further improve device performance. Here we report charge dynamics in an OSC using a perylene diimide (PDI) dimer acceptor. We use transient absorption spectroscopy to track the time evolution of electroabsorption caused by the dipolar electric field generated between electron-hole pairs as they separate after ionization at the donor-acceptor interface...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29145809/genome-wide-characterization-and-expression-profiling-of-pdi-family-gene-reveals-function-as-abiotic-and-biotic-stress-tolerance-in-chinese-cabbage-brassica-rapa-ssp-pekinensis
#8
Md Abdul Kayum, Jong-In Park, Ujjal Kumar Nath, Gopal Saha, Manosh Kumar Biswas, Hoy-Taek Kim, Ill-Sup Nou
BACKGROUND: Protein disulfide isomerase (PDI) and PDI-like proteins contain thioredoxin domains that catalyze protein disulfide bond, inhibit aggregation of misfolded proteins, and function in isomerization during protein folding in endoplasmic reticulum and responses during abiotic stresses.Chinese cabbage is widely recognized as an economically important, nutritious vegetable, but its yield is severely hampered by various biotic and abiotic stresses. Because of, it is prime need to identify those genes whose are responsible for biotic and abiotic stress tolerance...
November 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29143473/recent-advancements-of-rylene-imide-dyes-synthesis-and-application-as-organic-semiconducting-materials
#9
Jiajing Feng, Wei Jiang, Zhaohui Wang
Rylene imide dyes have been among the most promising organic semiconducting materials for several years due to their remarkable optoelectronic properties and high chemical/thermal persistency. In the past decades, various spendid rylene imide dyes have been developed for optoelectronic devices, such as organic solar cells (OSCs) and organic field-effect transistors (OFETs). Recently, tremendous progress of perylene diimides (PDIs) and the analogues used in OSCs has been witnessed attributed to their ease of functionalization...
November 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29143006/cooperative-supramolecular-polymerization-of-a-perylene-diimide-derivative-and-its-impact-on-electron-transporting-properties
#10
Dipankar Basak, Deep Sankar Pal, Tsuneaki Sakurai, Satoru Yoneda, Shu Seki, Suhrit Ghosh
H-bonding-promoted supramolecular polymerization of a perylene diimide (PDI) building block and its impact on charge carrier mobility were studied. PDI-1, containing a carboxylic acid group, exhibits H-aggregation in a non-polar solvent decalin while in THF or chloroform it remains in the monomeric form. In contrast, the control molecule PDI-2, containing an ester group does not show aggregation even in decalin, indicating that H-bonding among the carboxylic acid is primarily responsible for H-aggregation, which is further verified by the FT-IR study...
November 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29142430/topical-delivery-of-withania-somnifera-crude-extracts-in-niosomes-and-solid-lipid-nanoparticles
#11
Tawona N Chinembiri, Minja Gerber, Lissinda H du Plessis, Jan L du Preez, Josias H Hamman, Jeanetta du Plessis
Background: Withania somnifera is a medicinal plant native to India and is known to have anticancer properties. It has been investigated for its anti-melanoma properties, and since melanoma presents on the skin, it is prudent to probe the use of W. somnifera in topical formulations. To enhance topical drug delivery and to allow for controlled release, the use of niosomes and solid lipid nanoparticles (SLNs) as delivery vesicles were explored. Objective: The objective of this study is to determine the stability and topical delivery of W...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142419/antipsoriatic-and-anti-inflammatory-studies-of-berberis-aristata-extract-loaded-nanovesicular-gels
#12
Nimisha, Dilshad Ali Rizvi, Zeeshan Fatima, Neema, Chanchal Deep Kaur
Objective: Novel nanovesicular gel of Berberis aristata extract was developed and evaluated for its anti-inflammatory and antipsoriatic activity. Materials and Methods: Transferosomes were prepared using soya phosphatidylcholine and edge activators (Tween 80, Span 80, and sodium deoxycholate) by a modified lipid film hydration technique using rotary evaporator and evaluated for various parameters. The quantification and standardization of extract have been carried out using its alkaloid content as berberine as biomarker...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29139323/jaboticaba-plinia-peruviana-extract-nanoemulsions-development-stability-and-in-vitro-antioxidant-activity
#13
Letícia Mazzarino, Heloísa da Silva Pitz, Ana Paula Lorenzen Voytena, Adriana Carla Dias Trevisan, Rosa Maria Ribeiro-Do-Valle, Marcelo Maraschin
OBJECTIVE: The aim of this work is to develop and characterize nanoemulsions containing jaboticaba extract (Plinia peruviana) aiming pharmaceutical and cosmetic applications. METHODS: Nanoemulsions were prepared by high-pressure homogenization method using different concentrations of components (oil, surfactant, and extract) and homogenization pressures, in order to optimize the preparation conditions. Both unloaded and extract-loaded nanoemulsions were characterized according their size, polydispersity, zeta potential, pH, morphology, and physical stability...
November 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29138806/effect-of-bis-hydroxymethyl-alkanoate-curcuminoid-derivative-mth-3-on-cell-cycle-arrest-apoptotic-and-autophagic-pathway-in-triple-negative-breast-adenocarcinoma-mda-mb-231-cells-an-in-vitro-study
#14
Ling-Chu Chang, Min-Tsang Hsieh, Jai-Sing Yang, Chi-Cheng Lu, Fuu-Jen Tsai, Je-Wei Tsao, Yu-Jen Chiu, Sheng-Chu Kuo, Kuo-Hsiung Lee
Curcumin has been shown to exert potential antitumor activity in vitro and in vivo involved in multiple signaling pathways. However, the application of curcumin is still limited because of its poor hydrophilicity and low bio-availability. In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells. This study investigated the effect of MTH-3 on cell viability, cell cycle and induction of autophagy and apoptosis in MDA-MB-231 cells...
November 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29137746/ultrasonically-tailored-chemically-engineered-and-qbd-enabled-fabrication-of-agomelatine-nanoemulsion-optimization-characterization-ex-vivo-permeation-and-stability-study
#15
Shakeeb Ahmed, Azka Gull, Mahtab Alam, Mohd Aqil, Yasmin Sultana
The objective of present study was to develop a nanoemulsion formulation of agomelatine (BCS class II drug) for the solubility enhancement. Capmul MCM, Tween 80 and PEG-400 were selected as oil, surfactant and co-surfactant respectively. The high energy ultrasonication method was used for the preparation of nanoemulsion. Three-factor three-level central composite design was employed to get the best formulation. The independent variables selected for the optimization were % oil, %Smix and sonication time (second)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29131542/the-three-dimensional-structure-of-twisted-benzo-ghi-perylene-triimide-dimer-as-a-non-fullerene-acceptor-for-inverted-perovskite-solar-cells
#16
Priyadharsini Karuppuswamy, Hung-Cheng Chen, Pen-Cheng Wang, Chao-Ping Hsu, Ken-Tsung Wong, Chih Wei Chu
In this work, we introduced benzo[ghi]perylenetriimide (BPTI) derivatives including monomer and twisted dimer (t-BPTI) as an alternative electron transport layer (ETL) material to replace the commonly used PC61BM in inverted planar heterojunction perovskite solar cells. Moreover, the double ETL layer was applied in our perovskite solar cells with structure of glass/ITO/PEDOT:PSS/perovskite/BPTI/C60 or PDI-C4/BCP/Al. Use of a double ETL layer structure can effectively eliminate the leakage current. The devices with the t-BPTI/C60 double ETL layer yield an average power conversion efficiency of 10...
November 12, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29131488/dorsal-root-ganglion-stimulation-used-for-the-treatment-of-chronic-neuropathic-pain-in-the-groin-a-single-center-study-with-long-term-prospective-results-in-34-cases
#17
Matthias Hubert Morgalla, Anil Bolat, Marcos Fortunato, Guilherme Lepski, Bankim Subhash Chander
OBJECTIVE: Chronic neuropathic pain in the groin is a severe condition and difficult to treat. Dorsal root ganglion stimulation (DRGS) covers discrete painful areas precisely with its stimulation power in comparison to spinal cord stimulation (SCS). It was our hypothesis that DRGS provides a long-term relief of chronic groin pain over a period of more than three years. MATERIALS AND METHODS: Patients (age >18 years) with chronic neuropathic groin pain were prospectively examined...
November 13, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29128432/czech-version-of-the-patient-dignity-inventory-translation-and-validation-in-incurable-patients
#18
Helena Kisvetrová, David Školoudík, Libuše Danielová, Kateřina Langová, Renáta Váverková, Milena Bretšnajdrová, Yukari Yamada
CONTEXT: The Patient Dignity Inventory (PDI) is a valid, reliable screening tool to assess a range of issues that have been reported to affect the sense of dignity in patients with life-limiting conditions. OBJECTIVES: We investigated the item characteristics, factor structure, and reliability of the Czech version of the PDI (PDI-CZ) among cancer and non-cancer patients. METHODS: The PDI was translated into the Czech language following state-of-the-art criteria (a five-stage proceeding method for the translation)...
November 8, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29128202/multi-hazard-risk-assessment-of-coastal-vulnerability-from-tropical-cyclones-a-gis-based-approach-for-the-odisha-coast
#19
Bishnupriya Sahoo, Prasad K Bhaskaran
The coastal region bordering the East coast of India is a thickly populated belt exposed to high risk and vulnerability from natural hazards such as tropical cyclones. Tropical cyclone frequencies that develop over the Bay of Bengal (average of 5-6 per year) region are much higher as compared to the Arabian Sea thereby posing a high risk factor associated with storm surge, inland inundation, wind gust, intense rainfall, etc. The Odisha State in the East coast of India experiences the highest number of cyclone strikes as compared to West Bengal, Andhra Pradesh, and Tamil Nadu...
November 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29124836/living-ab-initio-emulsion-polymerization-of-methyl-methacrylate-in-water-using-a-water-soluble-organotellurium-chain-transfer-agent-under-thermal-and-photochemical-conditions
#20
Weijia Fan, Masatoshi Tosaka, Shigeru Yamago, Michael F Cunningham
Ab initio emulsion polymerization of methyl methacrylate (MMA) using a water-soluble organotellurium chain transfer agent in the presence of the surfactant Brij 98 in water is reported. Polymerization proceeded under both thermal and visible light-irradiation conditions giving poly(methyl methacrylate) (PMMA) with controlled molecular weight and low dispersity (Đ<1.5). Despite the formation of an opaque latex, the photo-activation of the organotellurium dormant species took place efficiently as demonstrated by the quantitative monomer conversion and temporal control...
November 10, 2017: Angewandte Chemie
keyword
keyword
29483
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"