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Anam Khan, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Yasmin Sultana, Asgar Ali, Khalid Khan
The present study was designed to develop and optimize Temozolomide nano lipid chitosan gel delivery (TMZNLCHG) to target the brain through nasal route. The formulation was developed using chitosan as a gelling agent and Vit E: gelucire 44/14 blend as lipid. The formulations were evaluated for particle size, drug loading, morphology, drug release, nasal diffusion, cell line study, and histopathology study. The average particle size, PDI, %EE, loading, drug release, and % permeation were found to be 134 nm, 0...
May 15, 2018: International Journal of Biological Macromolecules
Sebile Işık Büyükekşi, Ahmet Karatay, Nursel Acar, Betül Küçüköz, Ayhan Elmali, Abdurrahman Şengül
Perylene diimides (PDIs) are among the most versatile and functional dyes for supramolecular structures displaying characteristic high absorptions and photo-luminescence properties as the prerequisite for optoelectronic thin film devices. Despite intense investigations into these semi-conducting and electro-active materials, details of their electronic structure are still under examination. In particular, non-planar twisted PDIs as an electron acceptor is a promising model system for efficient charge generation and transport processes...
May 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Yun-Cheng Li, Geng Zhong, Fan-Bing Meng, Hua Yu, Da-Yu Liu, Lian-Xin Peng
BACKGROUND: Konjac glucomannan octenyl succinate (KGOS) has excellent emulsification properties and can potentially be used in the food industry as an emulsifier, stabilizer and microcapsule wall material. In present study, the in vitro digestion properties and emulsification capability and stability of KGOS were studied to evaluate the transport and encapsulation characteristics of KGOS to insoluble bioactive nutrients. RESULTS: Confocal scanning laser microscopy (CSLM) suggested that oil droplets could be encapsulated by KGOS into regular spheres...
May 15, 2018: Journal of the Science of Food and Agriculture
You Gyoung Yi, In Young Sung, Jin Sook Yuk
Objective: To compare the scores of the Bayley Scales of Infant Development second edition (BSID-II) and the third edition, Bayley-III, in children with suspected developmental delay and to determine the cutoff score for developmental delay in the Bayley-III. Methods: Children younger than 42 months (n=62) with suspected developmental delay who visited our department between 2014 and 2015 were assessed with both the BSID-II and Bayley-III tests. Results: The mean Bayley-III Cognitive Language Composite (CLC) score was 5...
April 2018: Annals of Rehabilitation Medicine
Komail Sadrjavadi, Behzad Shahbazi, Ali Fattahi
The objective of the present study was to prepare and characterized de-esterified tragacanth-chitosan nanoparticles (DET-CS NPs) as a novel carrier for methotrexate, with a view to improve drug efficacy and target ability. The preparation process was optimized using Taguchi design. NPs were characterized for size, zeta potential, morphology, thermal stability, loading efficiency, cytotoxicity and cellular uptake. Taguchi design indicated that the molecular weight of chitosan possessed the most effect on the zeta potential, PDI, and zeta deviation, and the size of nanoparticles was significantly affected by the DET concentration...
May 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Joseph F Welch, Bruno Archiza, Jordan A Guenette, Christopher R West, A William Sheel
KEY POINTS: Diaphragmatic fatigue (DF) elicits a sympathetically mediated metaboreflex resulting in increased heart rate, blood pressure and limb vascular resistance. Women may be more resistant to DF compared to men and therefore, it was hypothesised that women would experience an attenuated inspiratory muscle metaboreflex during inspiratory pressure-threshold loading (PTL) performed to task failure. At the time of PTL task failure, the severity of DF was not different between sexes; however, inspiratory muscle endurance time was significantly longer in women than men...
May 14, 2018: Journal of Physiology
Vijaykumar Sutariya, Jared Tur, Shannon J Kelly, Kathleen Halasz, Kalyan C Chapalamadugu, Rohini Nimbalkar, Yashwant V Pathak, Robert Weigel, Todd Daviau, Janice Cacace, Travis Webb, Marco Brotto, Srinivas Tipparaju
Glucocorticoids are utilized for its anti-inflammatory properties in the skeletal muscle and arthritis. However, the major drawback with use of glucocorticoids is that it leads to senescence and toxicity. Therefore, based on the idea that decreasing particle size allows for increased surface area and bio-availability of the drug, in the present study we hypothesized that nano-delivery of dexamethasone will offer increased efficacy and decreased toxicity. The dexamethasone loaded PLGA (poly lactic-co-glycolic acid) nanoparticles were prepared using nanoprecipitation method...
May 14, 2018: Canadian Journal of Physiology and Pharmacology
Zahra Hadian, Majedeh Maleki, Khosro Abdi, Fatemeh Atyabi, Abdoreza Mohammadi, Ramin Khaksar
The aim of the present study was to formulate β-cyclodextrin (β-CD) nanoparticles loaded with geraniol (GR) essential oil (EO) with appropriate physicochemical properties. Complexation of GR with β-CD was optimized by evaluation of four formulations, using the co-precipitation method, and the encapsulation efficiency (EE), loading, size, particle size distribution (PDI) and zeta potential were investigated. Further characterization was performed with nuclear magnetic resonance spectroscopy (1 H NMR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and infra-red (IR) spectroscopy analysis...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Krutika K Sawant, Bharat Bhushan Subudhi
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administration further limits its utility. Hence, the aim of this study was to investigate whether ibuprofen loaded mucoadhesive microemulsion (MMEI) could enhance the brain uptake and could also protect the dopaminergic neurons from MPTP-mediated neural inflammation. In this work, ibuprofen loaded polycarbophil based mucoadhesive microemulsion (MMEI) was developed by using response surface methodology (RSM)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
Xiao-Han Wang, Rui-Na Zhong, Bao-de Shen, Cheng-Ying Shen, Xiao Liu, Bo Dai, Hai-Long Yuan
Astilbil nanosuspension (AT-NS) was prepared by an antisolvent precipitation method. The formula and process of AT-NS were optimized by the single factor experiment. AT-NS was prepared under the optimal conditions, and its morphology and crystallinity were characterized. In vitro release of AT-NS was also determined. The particle size of AT-NS stabilized by PVP K30 was (149±3) nm, and the polydispersity index (PDI) and stability index (SI) were 0.137±0.014 and 0.940±0.012, respectively. The results of SEM showed that AT-NS was spherical...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Yeni Kim, Eun-Hee Ha, Hyesook Park, Mina Ha, Yangho Kim, Yun-Chul Hong, Eun Jung Lee, Hyesook Kim, Namsoo Chang, Bung-Nyun Kim
OBJECTIVES: In this prospective cohort study, the effects of prenatal Hg exposure on neurocognitive development during the first 3years of life were investigated. METHODS: The maternal blood levels of Hg were assessed during pregnancy and in cord blood. Maternal fish intake was assessed by interviewing the weekly frequency of fish intake during pregnancy. Maternal n-3 and n-6 fatty acid intake was estimated based on 24h recall food intake interview. The mental (MDI) and psychomotor (PDI) development index scores were assessed using the Bayley Scales of Infant Development at 6, 12, 24, 36months of age...
February 15, 2018: Science of the Total Environment
Jian-Mei Lu, Ming Wang, Qijian Zhang, Zhuang Li, Hua Li
The large polydispersity index of the functional pendant polymers has hindered their application in semiconductor field. Herein, a novel pendant polymer with perylenediimide (PDI) in the side chains was successfully synthesized through the ring-opening metathesis polymerization (ROMP) with a very low polydispersity index. The synthesized poymers were spin-coated to ITO substrate using 1,2-dichlorobenzene (o-DCB) and methanol (MeOH) mixed solvents, the fabricated film's surface morphologies and intermolecular pi-pi stacking could be adjusted through tuning of the ratio of o-DCB and MeOH, thereby, the sandwich structured device ITO/polymer/Al exhibited different electric behaviors, the threshold voltages of the devices were decreasing as MeOH was increased from 0 to 30% by volume, however, the device would change from unrewriteable to rewriteable device when MeOH was improved to 40%, and the probable mechanism was discussed...
May 9, 2018: Chemistry, An Asian Journal
Hong-Yan Lv, Rui-Jiang Zheng, Qiu-Li Wang, Peng-Shun Ren, Lin-Hong Jin, Xiu-Ling Gu, Lian-Xiang Li
BACKGROUND: To study the clinical and genetic features from a Chinese child with SATB2-associated syndrome (SAS) and review of literature. METHODS: The girl, 2 years 3 months old, is admitted to the Department of Pediatric Rehabilitation in our hospital. This patient has mental retardation, language development disorder, cleft palate II0, micrognathia, malocclusion, irritability and bilateral oblique palpebral fissure as a clinical manifestation and is treated for 3 months...
April 1, 2018: Clinical Laboratory
Tufan K Mukhopadhyay, Nicholas L MacLean, Marco Flores, Thomas L Groy, Ryan J Trovitch
We report the preparation and electronic structure determination of chelate-reduced Mn(I) compounds that are relevant to electrocatalytic proton reduction mediated by [(Ph2PPr PDI)Mn(CO)][Br]. Reducing [(Ph2PPr PDI)Mn(CO)][Br] with excess Na-Hg afforded a neutral paramagnetic complex, (Ph2PPr PDI)Mn(CO). This compound was found to feature a low spin Mn(I) center and a PDI radical anion as determined by magnetic susceptibility measurement (1.97 μB ), EPR spectroscopy ( S = 1 /2 ), and density functional theory calculations...
May 8, 2018: Inorganic Chemistry
Shalini Singh, Alka Lohani, Arun Kumar Mishra, Anurag Verma
The present study deals with the evaluation of antiaging potential of carrot seed oil-based cosmetic emulsions. Briefly, cosmetic emulsions composed of carrot seed oil in varying proportions (2, 4, and 6% w/v) were prepared using the hydrophile-lipophile balance (HLB) technique. Coconut oil, nonionic surfactants (Tween 80 and Span 80), and xanthan gum were used as the oil phase, emulgent, and emulsion stabilizer, respectively. The formed emulsions were evaluated for various physical, chemical, and biochemical parameters such as the zeta potential, globule size measurement, antioxidant activity, sun protection factor (SPF), skin irritation, and biochemical studies...
May 8, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Aleksandra Kawczyk-Krupka, Barbara Pucelik, Anna Międzybrodzka, Aleksander Sieroń, Janusz M Dąbrowski
Infected leg ulcers are painful, debilitating and immensely reducing patient's quality of life, therefore they are becoming a more and more significant clinical and socioeconomic problems nowadays. Increasing resistance to antibiotics, drugs and therapies is one of the most urgent challenge in medicine worldwide and requires searching for a new, innovative and more efficient medical strategies. One of the opportunities for the cure of leg ulcers is photodynamic inactivation (PDI), that has been widely used in the treatment of various bacterial, fungal and viral infections...
May 3, 2018: Photodiagnosis and Photodynamic Therapy
Gilberto García-Salazar, María de la Luz Zambrano-Zaragoza, David Quintanar-Guerrero
The Venturi tube (VT) is an apparatus that produces turbulence which is taken advantage of to produce nanoparticles (NP) by solvent displacement. The objective of this study was to evaluate the potential of this device for preparing NP of poly-ε-caprolactone. Response Surface Methodology was used to determine the effect of the operating conditions and optimization. The NP produced by VT were characterized by Dynamic Light-Scattering to determine their particle size distribution (PS) and polydispersity index (PDI)...
May 2, 2018: International Journal of Pharmaceutics
Wenqi Yang, Fang Wu, Ting Luo, Yuelan Zhang
Diabetic patients are more sensitive to ischemic injury than non-diabetics. Endoplasmic reticulum (ER) stress has been reported to be closely associated with the pathophysiology of ischemic injury in diabetes. The aim of the present study was to investigate the mechanisms involved in the progression of diabetes complicated by myocardial infarction (MI) and further verify the role of CCAAT/enhancer binding protein (C/EBP)-homologous protein (CHOP) using an in vitro model of diabetes/MI. The rats were exposed to 65 mg/kg streptozotocin (STZ) and left anterior descending (LAD) coronary artery ligation...
May 2018: Experimental and Therapeutic Medicine
Shabnam Peyvandi, Vann Chau, Ting Guo, Duan Xu, Hannah C Glass, Anne Synnes, Kenneth Poskitt, A James Barkovich, Steven P Miller, Patrick S McQuillen
BACKGROUND: Brain injury (BI) is reported in 60% of newborns with critical congenital heart disease as white matter injury (WMI) or stroke. Neurodevelopmental (ND) impairments are reported in these patients. The relationship between neonatal BI and ND outcome has not been established. OBJECTIVES: This study sought to determine the association between peri-operative BI and ND outcomes in infants with single ventricle physiology (SVP) and d-transposition of the great arteries (d-TGA)...
May 8, 2018: Journal of the American College of Cardiology
Kang-Kyun Wang, Eon Pil Shin, Hye-Jin Lee, Seung-Jin Jung, Jeong-Wook Hwang, Il Heo, Jong-Ho Kim, Min-Kyu Oh, Yong-Rok Kim
To inactivate methicillin-resistant Staphylococcus aureus (MRSA) with minimum damage to host cells and tissue, target-oriented photofunctional nanoparticles (TOPFNs) were fabricated and characterized. MRSA is a predominant infective pathogen even in hospital and non-hospital environments due to its ability to develop high levels of resistance to several classes of antibiotics through various pathways. To solve this major problem, photodynamic inactivation (PDI) method applies to treat antibiotic-resistant bacteria...
April 24, 2018: Journal of Photochemistry and Photobiology. B, Biology
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