keyword
MENU ▼
Read by QxMD icon Read
search

PDI

keyword
https://www.readbyqxmd.com/read/28345873/impact-of-semiconducting-perylene-diimide-nanoparticle-size-on-lymph-node-mapping-and-cancer-imaging
#1
Zhen Yang, Rui Tian, Jinjun Wu, Quli Fan, Bryant C Yung, Gang Niu, Orit Jacobson, Zhantong Wang, Gang Liu, Guocan Yu, Wei Huang, Jibin Song, Xiaoyuan Chen
Semiconducting molecules of perylene diimide (PDI) with strong light absorption property in the near-infrared region and good biocompatibility have received increasing attention in the field of theranostics, especially as photoacoustic (PA) imaging agents. Herein, we report a series of [64Cu]-labeled PDI nanoparticles (NPs) of different sizes (30, 60, 100 and 200 nm) as dual positron emission tomography (PET) and PA imaging probes and photothermal therapy agents. The precise size control of the PDI NPs can be achieved by adjusting the initial concentration of PDI molecules in the self-assembly process, and the photophysical property of different sized PDI NPs was studied in detail...
March 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28344477/development-and-characterization-of-methoxy-poly-ethylene-oxide-block-poly-%C3%AE%C2%B5-caprolactone-peo-b-pcl-micelles-as-vehicles-for-the-solubilization-and-delivery-of-tacrolimus
#2
Raisuddin Ali, Abubakar Farah, Ziyad Binkhathlan
Tacrolimus is a potent immunosuppressant; however, it suffers from several problems such as poor water solubility (4-12 μg/mL), low and variable oral bioavailability in patients, and narrow therapeutic window that could not be solved by the currently available i.v. formulation (Prograf®). Moreover, Prograf® contains HCO-60 (PEGylated castor oil) as a surfactant, which is reported to cause several side effects including hypersensitivity reactions. Therefore, the aim of the present study was to investigate the potential of PEO-b-PCL polymeric micelles as alternative vehicles for the solubilization and delivery of tacrolimus...
February 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28343120/nanoemulgel-using-a-bicephalous-heterolipid-as-a-novel-approach-to-enhance-transdermal-permeation-of-tenofovir
#3
Sanjeev Rambharose, Rahul S Kalhapure, Thirumala Govender
Improvements in permeation enhancement strategies, such as nanoemulsions (NEs) and nanoemulgels (NEGs), have led to a renewed interest in transdermal drug delivery (TDD). This study aimed to investigate the potential of LLA1E, a novel dendritic permeation enhancer, as an oily phase in the development of a NEG for the TDD of tenofovir (TNF). TNF loaded NEs (TNEs) were prepared and analysed for mean globule diameter (MGD), polydispersity index (PDI), zeta potential (ZP) and morphology. NEGs of the TNEs (TNEGs) were prepared and evaluated for ex vivo transdermal permeation efficacy...
March 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28342753/evaluation-of-chitosan-as-a-wall-material-for-microencapsulation-of-squalene-by-spray-drying-characterization-and-oxidative-stability-studies
#4
Lekshmi R G Kumar, N S Chatterjee, C S Tejpal, K V Vishnu, K K Anas, K K Asha, R Anandan, Suseela Mathew
The present study was aimed at investigating the efficacy of chitosan as a wall material for microencapsulation of squalene by spray drying for functional food applications. Based on different core to wall material ratio (1:1, 0.5:1 and 0.3:1 on w/w basis), emulsions were prepared and evaluated in terms of emulsion stability, particle size, zeta potential, polydispersity Index (PDI), rheology and microstructure. The optimized emulsion combination was spray dried and characterized, physically and chemically...
March 22, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28342057/preparation-of-drug-loaded-plga-peg-nanoparticles-by-membrane-assisted-nanoprecipitation
#5
Airama Albisa, Emma Piacentini, Victor Sebastian, Manuel Arruebo, Jesus Santamaria, Lidietta Giorno
PURPOSE: The aim of this work is to develop a scalable continuous system suitable for the formulation of polymeric nanoparticles using membrane-assisted nanoprecipitation. One of the hurdles to overcome in the use of nanostructured materials as drug delivery vectors is their availability at industrial scale. Innovation in process technology is required to translate laboratory production into mass production while preserving their desired nanoscale characteristics. METHODS: Membrane-assisted nanoprecipitation has been used for the production of Poly[(D,L lactide-co-glycolide)-co-poly ethylene glycol] diblock) (PLGA-PEG) nanoparticles using a pulsed back-and-forward flow arrangement...
March 24, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28340915/quality-improvement-program-reduces-perioperative-dental-injuries-a-review-of-64-718-anesthetic-patients
#6
Yi-Wei Kuo, I-Cheng Lu, Hui-Ying Yang, Shun-Li Chiu, Hung-Te Hsu, Kuang-I Cheng
BACKGROUND: Perioperative dental injury (PDI) is a common adverse event associated with anesthesia that can easily lead to medicolegal litigation. A quality improvement program was conducted with the electronic, standardized dental chart to document dentition before anesthesia and dentist consultation when necessary. This study aimed to reduce PDIs through execution of a quality improvement program. METHODS: We reviewed the 42-month interval anesthetic records of 64,718 patients who underwent anesthesia...
December 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28340483/improving-the-water-solubility-and-antimicrobial-activity-of-silymarin-by-nanoencapsulation
#7
Ji-Soo Lee, Da Young Hong, Eun Suh Kim, Hyeon Gyu Lee
The aims of this study were to improve the water solubility and antimicrobial activity of milk thistle silymarin by nanoencapsulation and to assess the functions of silymarin nanoparticle-containing film as an antimicrobial food-packaging agent. Silymarin nanoparticles were prepared using water-soluble chitosan (WCS) and poly-γ-glutamic acid (γ-PGA). As the WCS and silymarin concentrations increased, particle size and polydispersity index (PDI) significantly increased. Nanoencapsulation significantly improved the water solubility of silymarin 7...
March 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28337259/intranasal-basic-fibroblast-growth-factor-attenuates-endoplasmic-reticulum-stress-and-brain-injury-in-neonatal-hypoxic-ischaemic-injury
#8
Zhenlang Lin, Yingying Hu, Zhouguang Wang, Shulin Pan, Hao Zhang, Libing Ye, Hongyu Zhang, Mingchu Fang, Huai Jiang, Junming Ye, Jian Xiao, Li Liu
Brain injury secondary to birth asphyxia is the major cause of death and long-term disability in newborns. Intranasal drug administration enables agents to bypass the blood-brain barrier (BBB) and enter the brain directly. In this study, we determined whether intranasal basic fibroblast growth factor (bFGF) could exert neuroprotective effects in neonatal rats after hypoxic-ischaemic (HI) brain injury and assessed whether attenuation of endoplasmic reticulum (ER) stress was associated with these neuroprotective effects...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28334689/design-characterization-and-in-vitro-evaluation-of-linalool-loaded-solid-lipid-nanoparticles-as-potent-tool-in-cancer-therapy
#9
Boris Rodenak-Kladniew, German A Islan, Margarita G de Bravo, Nelson Durán, Guillermo R Castro
Linalool (LN) is a monoterpene found in essential oils of plants and herbs that produces multiple effects on the mevalonate pathway and interesting antiproliferative activity in cancer cells. However, due to its poor aqueous solubility, an efficient vehicle is needed to improve its administration and bioavailability in physiological media. LN encapsulation in solid lipid nanoparticles (SLN) with different compositions was explored and in vitro tested in two cancer cell lines. SLN of myristyl myristate (MM), cetyl esters (SS) and cetyl palmitate (CP) were prepared by sonication in the presence of Pluronic(®)F68 as surfactant...
March 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28328836/the-efficacy-of-periarticular-drug-infiltration-for-postoperative-pain-after-total-hip-arthroplasty-a-systematic-review-and-meta-analysis
#10
Yanyang Wang, Fuqiang Gao, Wei Sun, Bailiang Wang, Wanshou Guo, Zirong Li
BACKGROUND: The ability of intraoperative periarticular drug infiltration (PDI) to control pain after total hip arthroplasty (THA) has been studied for many times, but it still remains controversial. Therefore, we undertook a meta-analysis to evaluate the efficacy and safety of PDI on postoperative pain after THA. METHODS: Databases, including Pubmed, Medline, Embase, Web of Science, and Cochrane library, were searched to identify randomized controlled trials concerning PDI for pain management in patients undergoing THA...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328182/coordination-polymerization-of-renewable-3-methylenecyclopentene-with-rare-earth-metal-precursors
#11
Bo Liu, Shihui Li, Meiyan Wang, Dongmei Cui
Coordination polymerization of renewable 3-methylenecyclopentene has been investigated for the first time using rare-earth metal-based precursors bearing various bulky ligands. All the prepared complexes catalyze controllable polymerization of 3-methylenecyclopentene into high molecular weight polymers, of which the NPN- and NSN-tridentate non-Cp ligated lutetium-based catalytic systems exhibited extremely high activities up to 11 520 kg/(molLu ⋅h) in a dilute toluene solution (3.2 g/100 mL) at room temperature...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28319867/phototherapeutic-spectrum-expansion-through-synergistic-effect-of-mesoporous-silica-trio-nanohybrids-against-antibiotic-resistant-gram-negative-bacterium
#12
Yaswanth Kuthati, Ranjith Kumar Kankala, Prabhakar Busa, Shi-Xiang Lin, Jin-Pei Deng, Chung-Yuan Mou, Chia-Hung Lee
The extensive impact of antibiotic resistance has led to the exploration of new anti-bacterial modalities. We designed copper impregnated mesoporous silica nanoparticles (Cu-MSN) with immobilizing silver nanoparticles (SNPs) to apply photodynamic inactivation (PDI) of antibiotic-resistant E. coli. SNPs were decorated over the Cu-MSN surfaces by coordination of silver ions on diamine-functionalized Cu-MSN and further reduced to silver nanoparticles with formalin. We demonstrate that silver is capable of sensitizing the gram-negative bacteria E...
March 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28300659/milk-derived-exosomes-for-oral-delivery-of-paclitaxel
#13
Ashish K Agrawal, Farrukh Aqil, Jeyaprakash Jeyabalan, Wendy A Spencer, Joshua Beck, Beth W Gachuki, Sara S Alhakeem, Karine Oben, Radha Munagala, Subbarao Bondada, Ramesh C Gupta
In this report milk-derived exosomes have been investigated for oral delivery of the chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional i.v. therapy for improved efficacy and reduced toxicity. PAC-loaded exosomes (ExoPAC) were found to have a particle size of ~108nm, a narrow particle size distribution (PDI ~0.190), zeta potential (~ -7mV) and a practical loading efficiency of ~8%. Exosomes and ExoPAC exhibited excellent stability in the presence of simulated-gastrointestinal fluids, and during the storage at -80°C...
March 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28298446/folding-of-a-single-domain-protein-entering-the-endoplasmic-reticulum-precedes-disulfide-formation
#14
Philip J Robinson, Marie Anne Pringle, Cheryl A Woolhead, Neil J Bulleid
The relationship between protein synthesis, folding and disulfide formation within the endoplasmic reticulum (ER) is poorly understood. Previous studies have suggested pre-existing disulfide links are absolutely required to allow protein folding and, conversely, that protein folding occurs prior to disulfide formation. To address the question of what happens first within the ER; that is, protein folding or disulfide formation, we studied folding events at the early stages of polypeptide chain translocation into the mammalian ER using stalled translation intermediates...
March 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28295043/chlorin-e6-mediated-photodynamic-inactivation-for-multidrug-resistant-pseudomonas-aeruginosa-keratitis-in-mice-in-vivo
#15
Ming-Feng Wu, Mona Deichelbohrer, Thomas Tschernig, Matthias W Laschke, Nóra Szentmáry, Dirk Hüttenberger, Hans-Jochen Foth, Berthold Seitz, Markus Bischoff
Following corneal epithelium scratches, mouse corneas were infected with the multidrug resistant (MDR) P. aeruginosa strain PA54. 24 hours later, 0% (for control group), 0.01%, 0.05% or 0.1% Chlorin e6 (Ce6), a second generation photosensitizer derived from chlorophyll, was combined with red light, for photodynamic inactivation (PDI). 1 hour or 2 days later, entire mouse eyes were enucleated and homogenized for counting colony forming units (CFU) of P. aeruginosa. For comparison, 0.1% Ce6 mediated PDI was started at 12 hours post infection, and 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28291801/early-diagnosis-of-mild-cognitive-impairment-and-mild-dementia-through-basic-and-instrumental-activities-of-daily-living-development-of-a-new-evaluation-tool
#16
Elise Cornelis, Ellen Gorus, Ingo Beyer, Ivan Bautmans, Patricia De Vriendt
BACKGROUND: Assessment of activities of daily living (ADL) is paramount to determine impairment in everyday functioning and to ensure accurate early diagnosis of neurocognitive disorders. Unfortunately, most common ADL tools are limited in their use in a diagnostic process. This study developed a new evaluation by adopting the items of the Katz Index (basic [b-] ADL) and Lawton Scale (instrumental [i-] ADL), defining them with the terminology of the International Classification of Human Functioning, Disability and Health (ICF), adding the scoring system of the ICF, and adding the possibility to identify underlying causes of limitations in ADL...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28288440/schizophrenia-spectrum-personality-disorders-in-psychometrically-identified-schizotypes-at-two-year-follow-up
#17
P Kevin Bolinskey, Elizabeth A Smith, Kelly M Schuder, Dianna Cooper-Bolinskey, Kevin R Myers, Daniel V Hudak, Alison V James, Helen K Hunter, Jonathan H Novi, Janice P Guidi, Yelena Gonzalez, Erin F McTiernan, Kaitlin M Arnold, Carina A Iati, Irving I Gottesman
Earlier (Bolinskey et al., 2015), we reported that psychometrically identified schizotypes displayed greater symptom levels and higher incidences of schizophrenia spectrum (schizotypal, schizoid, paranoid, and avoidant) personality disorders (PDs). In this study, 49 schizotypes and 39 matched controls participated in follow-up assessments after two years. Participants were previously identified as schizotypes or controls based on scores on the Chapman Psychosis Proneness Scales (CPPS), and were interviewed at baseline and follow-up with the Personality Disorder Interview for DSM-IV (PDI-IV)...
March 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28288012/influence-of-upper-body-exercise-on-the-fatigability-of-human-respiratory-muscles
#18
Nicholas B Tiller, Ian G Campbell, Lee M Romer
PURPOSE: Diaphragm and abdominal muscles are susceptible to contractile fatigue in response to high-intensity, whole-body exercise. This study assessed whether the ventilatory and mechanical loads imposed by high-intensity, upper-body exercise would be sufficient to elicit respiratory muscle fatigue. METHODS: Seven healthy men (mean±SD: age 24±4 y; peak O2 uptake [V[Combining Dot Above]O2 peak] 31.9±5.3 ml/kg/min) performed asynchronous arm-crank exercise to exhaustion at work rates equivalent to 30% (heavy) and 60% (severe) of the difference between gas-exchange threshold and V[Combining Dot Above]O2 peak...
March 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28287501/evaluation-of-maltose-based-cationic-liposomes-with-different-hydrophobic-tails-for-plasmid-dna-delivery
#19
Bo Li, Liangliang Deng, Meiyan Liu, Youlin Zeng
In this paper, three cationic glycolipids with different hydrophobic chains Malt-DiC12MA (IX a), Malt-DiC14MA (IX b) and Malt-DiC16MA (IX c) were constructed by using maltose as starting material via peracetylation, selective 1-O-deacetylation, trichloroacetimidation, glycosylation, azidation, deacetylation, Staudinger reaction, tertiary amination and quaternization. Target compounds and some intermediates were characterized by ¹H-NMR, (13)C-NMR, ¹H-¹H COSY and ¹H-(13)C HSQC. The results of gel electrophoresis assay, atomic force microscopy images (AFM) and dynamic light scattering (DLS) demonstrate that all the liposomes could efficiently bind and compact DNA (N/P ratio less than 2) into nanoparticles with proper size (88 nm-146 nm, PDI < 0...
March 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28284054/nanostructured-lipid-carriers-of-olmesartan-medoxomil-with-enhanced-oral-bioavailability
#20
Vikram Kaithwas, Chander Parkash Dora, Varun Kushwah, Sanyog Jain
The current study explores the potential of nanostructured lipid carriers (NLCs) for oral bioavailability enhancement of olmesartan medoxomil (OLM) by systemic design approach. OLM-NLC was successfully prepared with optimized process parameters (i.e. amount of liquid lipid, total amount of lipid, drug content and surfactant concentration) using the Box-Behnken design of experiments for different response parameters (i.e. particle size, Polydispersity index and entrapment efficiency). Further, optimized formulation was validated which depicted nano size, homogenous distribution with optimum entrapment efficiency...
March 6, 2017: Colloids and Surfaces. B, Biointerfaces
keyword
keyword
29483
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"