keyword
https://read.qxmd.com/read/38537152/ligand-field-sensitive-spin-acceleration-in-the-iron-catalyzed-2-2-cycloaddition-of-unactivated-alkenes-and-dienes
#1
JOURNAL ARTICLE
Hanna H Cramer, Coralie Duchemin, Carli B Kovel, Junho Kim, Matthew V Pecoraro, Paul J Chirik
Redox-active pyridine(diimine) (PDI) iron catalysts promote the reversible [2 + 2] cycloaddition of alkenes and dienes to cyclobutane derivatives that have applications ranging from fuels to chemically recyclable polymers. Metallacycles were identified as key intermediates, and spin crossover from the singlet to the triplet surface was calculated to facilitate the reductive coupling step responsible for the formation of the four-membered ring. In this work, a series of sterically and electronically differentiated PDI ligands was studied for the [2 + 2] cycloaddition of ethylene and butadiene to vinylcyclobutane...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38534663/polylactic-glycolic-acid-mediated-delivery-of-plectasin-derivative-nz2114-in-staphylococcus-epidermidis-biofilms
#2
JOURNAL ARTICLE
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Yinhua Huang, Jianhua Wang
Antimicrobial peptides (AMPs) are antibiotic candidates; however, their instability and protease susceptibility limit clinical applications. In this study, the polylactic acid-glycolic acid (PLGA)-polyvinyl alcohol (PVA) drug delivery system was screened by orthogonal design using the double emulsion-solvent evaporation method. NZ2114 nanoparticles (NZ2114-NPs) displayed favorable physicochemical properties with a particle size of 178.11 ± 5.23 nm, polydispersity index (PDI) of 0.108 ± 0.10, ζ potential of 4...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534643/evaluation-of-the-potential-of-chitosan-nanoparticles-as-a-delivery-vehicle-for-gentamicin-for-the-treatment-of-osteomyelitis
#3
JOURNAL ARTICLE
Elliot Simpson, Humera Sarwar, Iain Jack, Deborah Lowry
Chitosan nanoparticle delivery systems have the potential for enhancing bone healing and addressing osteomyelitis. The objective was to deliver antimicrobial agents capable of preventing or treating osteomyelitis. Each formulation was optimized to achieve desired characteristics in terms of size (ranging from 100 to 400 nm), PDI (less than 0.5), zeta potential (typically negative), and in vitro release profiles for gentamicin. Entrapment percentages varied with gentamicin ranging from 10% to 65%. The chitosan nanoparticles exhibited substantial antimicrobial efficacy, particularly against P...
February 22, 2024: Antibiotics
https://read.qxmd.com/read/38534573/investigating-the-wound-healing-potential-of-a-nanoemulsion-gel-formulation-of-pituranthos-tortuosus-essential-oil
#4
JOURNAL ARTICLE
Badr Bahloul, Enis Ben Bnina, Assia Hamdi, Luis Castillo Henríquez, Dhaou Baccar, Nesrine Kalboussi, Aïmen Abbassi, Nathalie Mignet, Guido Flamini, José Roberto Vega-Baudrit
This study explores a nanoemulsion (NE)-based gel incorporating Tunisian Pituranthos tortuosus essential oil, with a focus on its wound-healing potential. The essential oil, extracted via hydrodistillation, underwent GC-MS analysis for compositional verification. The physicochemical characterization included dynamic light scattering (DLS), transmission electron microscopy (TEM), zeta potential measurement, pH, and viscosity. The gelification of the NE facilitated topical application. The results revealed an average extraction yield of 0...
February 20, 2024: Gels
https://read.qxmd.com/read/38532607/ultrastable-anion-radicals-in-ligand-dimerized-frameworks-for-self-accumulated-electrochemiluminescence
#5
JOURNAL ARTICLE
Qizhou Chen, Yuming Gu, Haomin Fu, Rengan Luo, Da Zhu, Pengfei Dong, Jing Ma, Huangxian Ju, Jianping Lei
Electrochemiluminescence (ECL) is a light-emitting process that occurs via an annihilation reaction among energetic radical intermediates, whose stabilities determine the ECL efficiency. In this study, a ligand-dimerized metal-organic framework (MOF) with ultrastable anion radical is designed as an efficient nanoemitter for self-accumulated ECL. Due to the nonplanar structure of perylene diimide (PDI) derivate, two PDI ligands in the framework form a J-dimer unit with a vertical distance of ∼5.74 Å...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38532324/-capsicum-annuum-oleoresin-nanoemulgel-design-characterization-and-in-vitro-investigation-of-anticancer-and-antimicrobial-activities
#6
JOURNAL ARTICLE
Ahmad M Eid, Hiba Natsheh, Linda Issa, Majdulin Zoabi, Monia Amer, Effat Mahamid, Ahmed Mousa
BACKGROUND: The use of naturally occurring bioactive materials is getting great attention owing to their safety and environmental properties. Oily compounds, known as oleoresins, are expected to provide an important source for the natural products industry aiming to develop novel treatments for skin conditions. In this work, Capsicum annuum oleoresin nanoemulgel formulations have been prepared and investigated for their antibacterial and anticancer properties. METHODOLOGY: Several C...
2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38530318/blindness-of-intentions-and-metacognitive-deficits-during-moral-judgements-in-schizophrenia
#7
JOURNAL ARTICLE
Tomasz Cyrkot, David Ramsey, Monika Wójta-Kempa, Błażej Misiak, Remigiusz Szczepanowski
BACKGROUND: Previous research has shown that moral judgments are affected by social cognitive abilities, such as theory of mind (ToM). This study examines how information about an actor's beliefs and the consequences of their actions affect the moral evaluation of the character's behavior in social events. Our research builds upon previous studies, which have shown that these factors contribute differently to moral judgments made by both adults and young children. OBJECTIVES: This study aimed to explore how participants with schizophrenia and healthy controls read stories about social situations in the context of moral judgments...
March 26, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38529741/tailoring-the-molecular-planarity-of-perylene-diimide-based-third-component-toward-efficient-ternary-organic-solar-cells
#8
JOURNAL ARTICLE
Yuxiang Li, Jiaqi Ren, Shujuan Liu, Baofeng Zhao, Zezhou Liang, Min Hun Jee, Hongmei Qin, Wenyan Su, Han Young Woo, Chao Gao
Incorporating a third component into binary organic solar cells (b-OSCs) has provided a potential platform to boost power conversion efficiency (PCEs). However, gaining control over the non-equilibrium blend morphology via the molecular design of the perylene diimide (PDI)-based third component toward efficient ternary organic solar cells (t-OSCs) still remains challenging. Herein, two novel PDI derivatives are developed with tailored molecular planarity, namely ufBTz-2PDI and fBTz-2PDI, as the third component for t-OSCs...
March 26, 2024: Small
https://read.qxmd.com/read/38529643/fucoidan-coated-liposomes-loaded-with-novel-antituberculosis-agent-preparation-evaluation-and-cytotoxicity-study
#9
JOURNAL ARTICLE
Manar M Obiedallah, Vsevolod V Melekhin, Yaroslava A Menzorova, Emmanuella T Bulya, Artem S Minin, Maxim A Mironov
In this article, we described a novel antituberculosis imidazotetrazine derivative designed in fucoidan coated liposomes to reduce its cytotoxicity and investigate its mucoadhesive properties. Firstly, fucoidan extracted from Ascophyllum nodosum was used for additional stabilization of liposomal suspensions and to give it mucoadhesive properties. PEG-600 and/or Tween-80 were used to increase the shelf life of liposomal suspension. The ratio of the fucoidan: lipids 1:2 was found to be the optimum that produces stable fucoidan coated liposomes...
March 26, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38527915/preparation-of-compound-salvia-miltiorrhiza-blumea-balsamifera-nanoemulsion-gel-and-its-effect-on-hypertrophic-scars-in-the-rabbit-ear-model
#10
JOURNAL ARTICLE
Teng Chen, Zuhua Wang, Xingchu Gong, Jiaojiao Zhang, Ning Zhang, Jing Yang, Yue Zhu, Ying Zhou
Hypertrophic scars (HS) still remain an urgent challenge in the medical community. Traditional Chinese medicine (TCM) has unique advantages in the treatment of HS. However, due to the natural barrier of the skin, it is difficult for the natural active components of TCM to more effectively penetrate the skin and exert therapeutic effects. Therefore, the development of an efficient drug delivery system to facilitate enhanced transdermal absorption of TCM becomes imperative for its clinical application. In this study, we designed a compound Salvia miltiorrhiza - Blumea balsamifera nanoemulsion gel (CSB-NEG) and investigated its therapeutic effects on rabbit HS models...
March 25, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38527566/development-of-a-hydrogel-containing-bisabolol-loaded-nanocapsules-for-the-treatment-of-atopic-dermatitis-in-a-balb-c-mice-model
#11
JOURNAL ARTICLE
Homa Karami, Mohammad Reza Niavand, Rasool Haddadi, Alireza Noriyan, Seyed Yaser Vafaei
α-Bisabolol (αBIS), a plant-derived compound with anti-inflammatory properties, is potentially a therapeutic agent for Atopic dermatitis. However, its poor water solubility and photoinstability limit its topical application. Therefore, the present study, aimed to develop cationic polymeric nanocapsules of αBIS to improve its skin delivery, photostability, and therapeutic efficacy. The αBIS- loaded nanocapsules were prepared using the solvent displacement technique. A Box-Behnken (BB) design was employed to statistically optimize formulation variables and αBIS- loaded nanocapsules characterized by particle size, surface charge and encapsulation efficiency...
March 23, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38527253/perylene-diimide-based-dimeric-electron-acceptors-with-molecular-conformations-for-perovskite-solar-cells
#12
JOURNAL ARTICLE
Gözde Murat Saltan, Tamer Yeşil, Aysun Albayrak Ötken, Ceylan Zafer, Haluk Dinçalp
This paper reports five novel PDI dimer type electron transport materials (ETMs) employing o-indoloquinoxaline (o-Iq), m-indoloquinoxaline (m-Iq), and cibalackrot (Ci) groups as the core building blocks and presents the twisted structures of PDI dimers coded as PDI-NHR-o-Iq, PDI-o-Iq, PDI-NHR-m-Iq, PDI-m-Iq and PDI-NHR-Ci dyes (see Scheme 1 and 2). We have systematically compared their photophysical, electrochemical, and optoelectronic properties with respect to the reference dye (2PDI-NHR), which is directly connected of two PDI planes...
March 25, 2024: ChemPlusChem
https://read.qxmd.com/read/38525678/surfactant-induced-alterations-in-optoelectronic-properties-of-perylene-diimide-dyes-modulating-sensing-responses-in-the-aqueous-environment
#13
JOURNAL ARTICLE
Animesh Pal, Nilanjan Dey
The compartmentalization effect of microheterogeneous systems, like surfactant aggregates, showcases altered optoelectronic properties of a perylene diimide-based chromogenic dye (PDI-Ala) compared to bulk water. The relatively hydrophobic microenvironment, poor hydration, and exceptionally large local concentration of dye molecules in the confined environment affect their interaction with target analytes. This realization intrigued us to investigate if micellization can modify the sensing properties (selectivity, sensitivity, response kinetics, output signal, etc...
March 25, 2024: Soft Matter
https://read.qxmd.com/read/38525014/influence-of-different-ratios-of-dspe-peg2k-on-ester-prodrug-self-assembly-nanoparticles-for-cell-migration-and-proliferation-suppression
#14
JOURNAL ARTICLE
Huiyun Zhang, Shunru Wei, Yunfei Hu, Yu Zhang, Hao Yao, Gang Qi, Michael Adu-Frimpong, Congyong Sun
BACKGROUND: Bufalin (BFL, an active anti-tumor compound derived from toad venom ) is limited in its application due to high toxicity and rapid metabolism of the cardiotonic steroid. Ester prodrug self-assembly nanoparticles have shown significant improved effects in addressing the above-mentioned issues. METHODS: An ester bond was formed between linoleic acid and bufalin to synthesize linoleic acid-bufalin prodrug (LeB). The self-assembly nanoparticles (LeB-PSNs) containing different mass ratios of DSPE-PEG2k and prodrug (6:4, 7:3, 8:2, 9:1 and 10:0) were prepared via co-precipitation method and defined as 6:4-PSNs, 7:3-PSNs, 8:2-PSNs, 9:1-PSNs and LeB-PSNs, respectively...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38524461/antimicrobial-activities-of-pistacia-lentiscus-essential-oils-nanoencapsulated-into-hydroxypropyl-beta-cyclodextrins
#15
JOURNAL ARTICLE
Obaydah Abd Alkader Alabrahim, Hassan Mohamed El-Said Azzazy
The rising risks of food microbial contamination and foodborne pathogens resistance have prompted an increasing interest in natural antimicrobials as promising alternatives to synthetic antimicrobials. Essential oils (EOs) obtained from natural sources have shown promising anticancer, antimicrobial, and antioxidant activities. EOs extracted from the resins of Pistacia lentiscus var. Chia are widely utilized for the treatment of skin inflammations, gastrointestinal disorders, respiratory infections, wound healing, and cancers...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38524420/encapsulation-of-black-rice-bran-extract-in-a-stable-nanoemulsion-effects-of-thermal-treatment-storage-conditions-and-in-vitro-digestion
#16
JOURNAL ARTICLE
Mohamed N Saleh, Mohamed Abdelbaset Salam, Esra Capanoglu
This study aimed to improve the dispersibility of phenolic compounds from black rice bran through the encapsulation process within nanoemulsion. The study focused on assessing the stability of the nanoemulsions, which were prepared using a combination of surfactants with distinct hydrophilic-lipophilic balance (HLB) values and sunflower oil under different thermal treatments and storage conditions. The study revealed a significant correlation between the mixed surfactant HLB value and the nanoemulsions properties, including average particle size, polydispersity index (PDI), and ζ-potential...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38519178/enhancing-acid-stability-of-citral-through-internal-structure-modulation-in-nanostructured-lipid-carriers-with-solid-lipids-and-phospholipids
#17
JOURNAL ARTICLE
Simin Feng, Jialu Sheng, Jiahao Yu, Yang Lin, Ping Shao
In this current study, the internal structure of nanostructured lipid carriers was modulated by phospholipids (lecithin PC, hydrogenated soybean phospholipid HPC) and solid lipids to achieve stable encapsulation of citral. The presence of high melting point HPC could construct α-crystalline type with more lattice defects and effectively inhibit β-ization. The HPC group could maintain the particle size at 155.9-186.9 nm, the polydispersity index (PDI) at 0.182-0.321, the Zeta potential at -57...
April 2024: Food Research International
https://read.qxmd.com/read/38518897/recent-advances-in-vascular-thiol-isomerases-and-redox-systems-in-platelet-function-and-thrombosis
#18
REVIEW
David W Essex, Lu Wang
There have been substantial advances in vascular protein disulfide isomerases (PDIs) in platelet function and thrombosis in recent years. There are four known prothrombotic thiol isomerases, PDI, ERp57, ERp72, ERp46 and one antithrombotic PDI, transmembrane protein 1 (TMX1). A sixth PDI, ERp5, may exhibit either pro- or anti-thrombotic properties in platelets. Studies on ERp46 in platelet function and thrombosis provide insight into the mechanisms by which these enzymes function. ERp46-catalyzed disulfide cleavage in the αIIbβ3 platelet integrin occurs prior to PDI-catalyzed events to maximally support platelet aggregation...
March 20, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38518872/harnessing-the-potential-of-fatty-acid-surfactant-based-micellar-gel-for-enhanced-topical-delivery-of-apremilast-in-psoriasis-treatment
#19
JOURNAL ARTICLE
Arun Sontakke, Sayali Dighe, Reena Sharma, Vivek Yadav, Sanyog Jain
Apremilast (APR) is a potent anti-psoriatic agent that inhibits the phosphodiesterase 4 enzyme. Due to the poor oral bioavailability and associated systemic side effects the clinical applicability of APR has been constrained. Nanotechnology-based carrier system presents a novel option to increase the efficacy of the topical treatment of APR. The current investigation deals with the development of fatty acid-surfactant conjugate-based hybrid mixed micellar gel (HMMG) for the topical delivery of APR. The developed micelles exhibited an average size of 83...
March 20, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38517314/simultaneous-spin-coating-and-ring-opening-metathesis-polymerization-for-the-rapid-synthesis-of-polymer-films
#20
JOURNAL ARTICLE
Zane J Parkerson, Liudmyla Prozorovska, Matthew P Vasuta, Tyler D Oddo, G Kane Jennings
We report a highly controlled technique for the synthesis of polymer films atop a substrate by combining spin coating with ring-opening metathesis polymerization (ROMP), herein termed spin coating ROMP (scROMP). The scROMP approach combines polymer synthesis and deposition into one process, fabricating films of up to 36 cm2 in under 3 min with orders-of-magnitude reduction in solvent usage. This method can convert numerous norbornene-type molecules into homopolymers and random copolymers as uniform films on both porous and nonporous substrates...
March 22, 2024: ACS Applied Materials & Interfaces
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