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https://www.readbyqxmd.com/read/28523257/comparative-evaluation-of-salivary-neopterin-levels-and-its-effects-to-periodontal-therapy-in-pre-and-post-menopausal-women
#1
Jammula Surya Prasanna, Chinta Sumadhura, Parupalli Karunakar, Naineni Rohini
OBJECTIVES: Neopterin is a valuable diagnostic biomarker, which is elevated in inflammatory conditions like periodontitis, that is characterized by destruction of the supporting structures of the teeth. Among the biomarkers, neopterin occurs in body fluids, and acts as a diagnostic marker for present and future disease activity. METHODS: Thirty female subjects with chronic periodontitis, mean age 50 years (40-60 years) were included in this study. Depending upon their menstrual history, subjects were categorized into two groups of fifteen each...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28522939/identification-of-protein-targets-in-cerebral-endothelial-cells-for-brain-arteriovenous-malformation-avms-molecular-therapies
#2
Margaret Simonian, Rachel R Ogorzalek Loo, Nalaka Rannulu, Joseph A Loo, Mark P Molloy, Marcus A Stoodley
BACKGROUND: To develop a new molecular targeted treatment for brain (AVMs), identification of membrane proteins that are localised on the AVM endothelium is crucial. Current treatment methods are surgery and radiosurgery. However, complete occlusion post radiosurgery are achieved within 3 years, while patient remain at risk of haemorrhage. This study aims to identify potential protein targets in AVM endothelial cells that discriminate these vessels from normal vessels; these proteins targets will be investigated for the molecular therapy of brain AVMs to promote rapid thrombosis after radiosurgery...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28521305/bushen-yizhi-formula-ameliorates-cognitive-dysfunction-through-sirt1-er-stress-pathway-in-samp8-mice
#3
Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wang
The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an aging model, SAMP8 mice, to explore whether BSYZ could protect dementia through SIRT1/endoplasmic reticulum (ER) stress pathway. Morris water maze and the fearing condition test results show that oral administration of BSYZ (1.46 g/kg/d, 2.92 g/kg/d and 5.84 g/kg/d) and donepezil (3 mg/kg/d) shorten the escape latency, increase the crossing times of the original position of the platform and the time spent in the target quadrant, and increase the freezing time...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28516508/near-infrared-photodynamic-inactivation-of-s-pneumoniae-and-its-interaction-with-raw-264-7-macrophages
#4
Ilaiáli S Leite, Mariana C Geralde, Ana C G Salina, Alexandra I Medeiros, Lívia N Dovigo, Vanderlei S Bagnato, Natalia M Inada
Pneumonia is the main cause of children mortality worldwide, and its major treatment obstacle stems from the microorganisms increasing development of resistance to several antibiotics. Photodynamic therapy has been presenting, for the last decades, promising results for some subtypes of cancer and infections. In this work we aimed to develop a safe and efficient in vitro protocol for photodynamic inactivation of Streptococcus pneumoniae, one of the most commonly found bacteria in pneumonia cases, using two near-infrared light sources and indocyanine green, a FDA approved dye...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28514393/-subtraction-ct-angiopulmonographic-assessment-of-the-vascular-bed-and-lung-perfusion-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-a-pilot-study
#5
T N Veselova, A Yu Demchenkova, T V Martynyuk, N M Danilov, S K Ternovoy, I E Chazova
AIM: To evaluate the vascular bed and lung perfusion in patients with chronic thromboembolic pulmonary hypertension (CTEPH) by computed tomography (CT) and to compare the severity of pulmonary arterial (PA) thrombotic lesions concurrent with parenchymal perfusion disorders with angiopulmonographic findings and clinical and hemodynamic characteristics. SUBJECTS AND METHODS: In the period from November 2015 to May 2016, 22 patients (7 men, 15 women) aged 27 to 67 years with a verified diagnosis of CTEPH were examined using an Aquilion ONE VISION Edition 640 (Toshiba Medical Systems, Japan) CT scanner with a 320-row detector...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28513348/measurement-invariance-between-genders-on-two-measures-of-borderline-personality-disorder
#6
Amy Paggeot, Steven Huprich
Gender bias in the diagnosis and assessment of borderline personality disorder (BPD) has been the subject of much controversy in the psychological research literature. Evidence regarding differential prevalence rates and diagnostic rates in clinical settings between genders has been mixed, and measurement bias is one potential explanation for these mixed findings. A total of 340 participants were recruited from a Midwestern university and four outpatient community mental health clinics. They were administered two structured clinical interviews for BPD that were then evaluated for measurement invariance...
May 17, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28511138/neurodevelopment-for-the-first-three-years-following-prenatal-mobile-phone-use-radio-frequency-radiation-and-lead-exposure
#7
Kyung-Hwa Choi, Mina Ha, Eun-Hee Ha, Hyesook Park, Yangho Kim, Yun-Chul Hong, Ae-Kyoung Lee, Jong Hwa Kwon, Hyung-Do Choi, Nam Kim, Suejin Kim, Choonghee Park
BACKGROUND: Studies examining prenatal exposure to mobile phone use and its effect on child neurodevelopment show different results, according to child's developmental stages. OBJECTIVES: To examine neurodevelopment in children up to 36 months of age, following prenatal mobile phone use and radiofrequency radiation (RFR) exposure, in relation to prenatal lead exposure. METHODS: We analyzed 1198 mother-child pairs from a prospective cohort study (the Mothers and Children's Environmental Health Study)...
May 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/28507445/evaluation-of-fatigue-and-its-correlation-with-quality-of-life-index-anxiety-symptoms-depression-and-activity-of-disease-in-patients-with-psoriatic-arthritis
#8
Claudio Carneiro, Mario Chaves, Gustavo Verardino, Ana Paula Frade, Pedro Guimaraes Coscarelli, Washington Alves Bianchi, Marcia Ramos-E-Silva, Sueli Carneiro
BACKGROUND: Psoriatic arthritis is associated with psychosocial morbidity and decrease in quality of life. Psychiatric comorbidity also plays an important role in the impairment of quality of life and onset of fatigue. OBJECTIVES: This study aimed to assess the prevalence of fatigue in psoriatic arthritis patients and to correlate it to quality of life indexes, functional capacity, anxiety, depression and disease activity. PATIENTS AND METHODS: This cross-sectional study was performed on outpatients with psoriatic arthritis...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28506203/optimization-of-microemulsion-based-transdermal-gel-of-triamcinolone
#9
Bhagyashree Chaudhari, Swati Jagdale
BACKGROUND: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which causes inflammation. Triamcinolone has half-life of 88 minutes. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis. Microemulgel offers advantage of better stability, better loading capacity and controlled release especially for drug with short half life. OBJECTIVE: Objective of the present study was to optimize microemulgel based transdermal delivery of triamcinolone...
April 25, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28503995/preparation-and-characterization-of-surface-modified-plga-polymeric-nanoparticles-used-to-target-treatment-of-intestinal-cancer
#10
Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Atta Abbas Naqvi, Farhan Jalees Ahmad
Docetaxel (DTX), a cytotoxic taxane, is a poor water-soluble drug and exhibits less oral bioavailability. Current research investigates the effective transport, for DTX-loaded chitosan (CS)-coated-poly-lactide-co-glycolide (PLGA)-nanoparticles (NPs) (DTX-CS-PLGA-NPs) and DTX-PLGA-NPs as well as a novel third-generation P-gp inhibitor i.e. GF120918 (Elacridar), across intestinal epithelium with its successive uptake by the tumour cells in an in vitro model. The prepared NPs showed a spherical shape particle size i...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28501017/golgi-independent-routes-support-protein-disulfide-isomerase-externalization-in-vascular-smooth-muscle-cells
#11
Thaís L S Araujo, Carolina G Fernandes, Francisco R M Laurindo
Extracellular pools of intracellular molecular chaperones are increasingly evident. The peri/epicellular(pec) pool of the endoplasmic reticulum redox chaperone protein disulfide isomerase-A1(PDI) is involved in thrombosis and vascular remodeling, while PDI externalization routes remain elusive. In endothelial cells, vesicular-type PDI secretion involves classical and unconventional pathways, while in platelets PDI exocytosis involves actin cytoskeleton. However, little is known about pecPDI in vascular smooth muscle cells(VSMC)...
May 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28500978/novel-polyglycerol-dioleate-based-cubosomal-dispersion-with-tailored-physical-characteristics-for-controlled-delivery-of-ondansetron
#12
M Mansour, A O Kamel, S Mansour, N D Mortada
In this study different amphiphilic lipids viz. glycerylmonooleate (GMO), Glycerylmonolinoleate (GML), Plurol(®) (polyglycerol 3-dioleate), Soya phosphatidylcholine (Soya PC), Dipalmitoyl-phosphatidylcholine (DPPC) and Dipalmitoyl- phosphatidylglycerol (DPPG) were screened for their ability to form cubosomes and the formed particles were optimized for controlled delivery using ondansetron as a model drug. Polarized optical microscopy and high resolution transmission electron microscopy were performed to investigate the morphology of the prepared particles...
April 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28497200/effect-of-lipoic-acid-on-the-biochemical-mechanisms-of-resistance-to-bortezomib-in-sh-sy5y-neuroblastoma-cells
#13
Daniele Tibullo, Cesarina Giallongo, Fabrizio Puglisi, Daniele Tomassoni, Giuseppina Camiolo, Martina Cristaldi, Maria Violetta Brundo, Carmelina Daniela Anfuso, Gabriella Lupo, Tomaso Stampone, Giovanni Li Volti, Francesco Amenta, Roberto Avola, Vincenzo Bramanti
Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research was to evaluate the effect of bortezomib (BTZ) (50 nM) on NB cell viability and how lipoic acid (ALA) (100 μM) modifies pharmacological response to this chemotherapeutic agent. Cell viability was assessed by ATP luminescence assay whereas expression of oxidative stress marker (i...
May 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28487189/mucopenetrating-nanoparticles-for-enhancement-of-oral-bioavailability-of-furosemide-in-vitro-and-in-vivo-evaluation-sub-acute-toxicity-study
#14
Salma El-Sayed Radwan, Magda Samir Sokar, Doaa Ali Abdelmonsif, Amal Hassan El-Kamel
The aim of this study was to formulate and evaluate chitosan (CS)/alginate (ALG) nanoparticles (NPs) loaded with furosemide (FSM) in an attempt to enhance its release, permeability and bioavailability. Non-everted gut sac method was used to evaluate the ex vivo permeation of FSM from its suspension and the selected CS/ALG NPs formulation. The pharmacokinetic parameters of FSM subsequent to oral administration of the selected formulation were assessed in rats. In vivo subacute toxicity study of the prepared blank and FSM loaded formulations was evaluated in rats...
May 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28487027/interleukin-11-up-regulates-endoplasmic-reticulum-stress-induced-target-pdia4-in-human-first-trimester-placenta-and-in%C3%A2-vivo-in-mice
#15
A L Winship, K Sorby, J Correia, A Rainczuk, J Yap, E Dimitriadis
Interleukin (IL)11 is a crucial factor for human trophoblast function and placentation. Elevated levels are associated with pregnancy complications including preeclampsia, intrauterine growth restriction (IUGR) and preterm birth. However, the regulation of IL11 in the placenta has not been investigated. We examined the effect of pro-inflammatory cytokines IL1β and TNFα, as well as low oxygen tension (2%) on IL11 levels in first trimester placental villous explants. IL1β upregulated IL11 mRNA and protein, while TNFα and low oxygen had no effect...
May 2017: Placenta
https://www.readbyqxmd.com/read/28484113/psychomotor-ability-in-children-prenatally-exposed-to-methylmercury-the-18-month-follow-up-of-tohoku-study-of-child-development
#16
Nozomi Tatsuta, Katsuyuki Murata, Miyuki Iwai-Shimada, Kozue Yaginuma-Sakurai, Hiroshi Satoh, Kunihiko Nakai
Fish contain nutrients essential to the developing fetal brain, but they are contaminated with methylmercury. The Tohoku Study of Child Development, now underway in the Sanriku coastal area of Miyagi prefecture, Japan, follows mother-child pairs to examine the risks and benefits of fish consumption during pregnancy, especially the effects of prenatal exposures to methylmercury, selenium, and docosahexaenoic acid (DHA) on child neurodevelopment. Children aged 18 months were administered the Bayley Scales of Infant Development second edition (BSID-II) and Kyoto Scale of Psychological Development (KSPD) in 2004-2008...
May 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28482586/biodegradable-poly-d-l-lactide-co-glycolide-poly-l-%C3%AE-glutamic-acid-nanoparticles-conjugated-to-folic-acid-for-targeted-delivery-of-doxorubicin
#17
Laura Jaimes-Aguirre, Enrique Morales-Avila, Blanca E Ocampo-García, Luis Alberto Medina, Gustavo López-Téllez, Brenda V Gibbens-Bandala, Vanessa Izquierdo-Sánchez
A novel targeted drug delivery nanoparticle system based on poly(D,L-lactide-co-glycolide) acid (PLGA) for delivery of doxorubicin (DOX) was developed. DOX-PLGA NPs were obtained by the emulsification-solvent evaporation technique. Then, their surface was modified with poly(L-γ-glutamic acid) (γ-PGA) and finally conjugated to modified folic acid (FA) as a targeting ligand. The surface modification and FA conjugation were followed by UV-Vis and FT-IR spectroscopies. Morphology was observed by TEM/SEM. Particle size, PDI and zeta potential were measured using DLS studies...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481661/in-vitro-and-in-vivo-evaluation-of-folate-mediated-pegylated-nanostructured-lipid-carriers-for-the-efficient-delivery-of-furanodiene
#18
Jianmei Zhang, Yunpeng He, Jianqi Jiang, Meng Li, Chenhao Jin, Lin Wang, Dongkai Wang
Furanodiene (FN) loaded FA-PEG2000-DSPE modified nanostructured lipid carriers (FA-FN-NLCs) were developed to increase the solubility and bioavailability of FN, prolong the circulation time in blood and improve the targeting ability. FA-FN-NLCs were prepared using emulsification-ultrasonic and low temperature-solidification method and optimized by central composition design (CCD). In vitro and in vivo characteristics of FA-FN-NLCs were investigated in detail. The optimized formulations exhibited a spherical shape with particle size of 127...
May 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28480807/tri-block-co-polymer-nanocarriers-for-enhancement-of-oral-delivery-of-felodipine-preparation-in-vitro-characterization-and-ex-vivo-permeation
#19
Sinar Sayed Fouad, Basant A Habib, Ghada M Elsayed
This study aimed to prepare, optimize and characterize a novel felodipine- loaded polymeric nanomicelles, using a pluronic mixture of F127 and P123. Thin-film hydration method was adopted for the preparation of different polymeric nanomicelles (T1-T12) according to a 4(1).3(1) full factorial design. Factors studied were: Pluronic ®: drug ratio (P:D ratio) (10, 20, 30 and 40 w/w) and percent of hydrophilic polymer (F127%) (33.33%, 50% and 66.67% w/w). Optimization criteria were to maximize transmittance percent (T%) and entrapment efficiency percent (EE%) and to minimize particle size (PS) and polydispersity index (PDI)...
May 7, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28476970/synthesis-and-characterisation-of-peg-modified-chitosan-nanocapsules-loaded-with-thymoquinone
#20
Suresh Kumar Vignesh Kumar, Ponnuswamy Renuka Devi, Saru Harish, Eswaran Hemananthan
Thymoquinone (TQ), a major bioactive compound of Nigella sativa seeds has several therapeutic properties. The main drawback in bringing TQ to therapeutic application is that it has poor stability and bioavailability. Hence a suitable carrier is essential for TQ delivery. Recent studies indicate biodegradable polymers are potentially good carriers of bioactive compounds. In this study, polyethylene glycol (PEG) modified chitosan (Cs) nanocapsules were developed as a carrier for TQ. Aqueous soluble low molecular weight Cs and PEG was selected among different biodegradable polymers based on their biocompatibility and efficacy as a carrier...
February 2017: IET Nanobiotechnology
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