Stephanie Dijk, Megan Jarman, Zhengxiao Zhang, Morgan Lawley, Muzammil Ahmad, Ricardo Suarez, Laura Rossi, Min Chen, Jessica Wu, Matthew W Carroll, Anthony Otley, Mary Sherlock, David R Mack, Kevan Jacobson, Jennifer C deBruyn, Wael El-Matary, Colette Deslandres, Mohsin Rashid, Peter C Church, Thomas D Walters, Hien Q Huynh, Michael G Surette, Anne M Griffiths, Eytan Wine
Exclusive enteral nutrition (EEN) is effective in inducing remission in pediatric Crohn disease (CD). EEN alters the intestinal microbiome, but precise mechanisms are unknown. We hypothesized that pre-diagnosis diet establishes a baseline gut microbiome, which then mediates response to EEN. We analyzed prospectively recorded food frequency questionnaires (FFQs) for pre-diagnosis dietary patterns. Fecal microbiota were sequenced (16SrRNA) at baseline and through an 18-month follow-up period. Dietary patterns, Mediterranean diet adherence, and stool microbiota were associated with EEN treatment outcomes, disease flare, need for anti-tumor necrosis factor (TNF)-α therapy, and long-term clinical outcomes...
April 2, 2024: Nutrients