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https://www.readbyqxmd.com/read/28430717/multilateral-functional-alterations-of-human-neutrophils-in-sepsis-from-the-point-of-diagnosis-to-the-seventh-day
#1
Akira Endo, Miko Okamura, Shunsuke Yoshikawa, Yasuhiro Otomo, Tomohiro Morio
Neutrophil functional changes caused by sepsis itself and their time-course variation have not been fully elucidated because previous studies targeted patients who had received therapeutic interventions. We explored the multilateral functions of circulating neutrophils in patients with severe sepsis or septic shock who had not yet undergone interventions, and followed their changes. Patients were treated based on the Surviving Sepsis Campaign Guidelines 2012. Neutrophil functions were evaluated on days 0 (before therapeutic intervention), 3, and 7 in fifty-nine sepsis patients...
April 20, 2017: Shock
https://www.readbyqxmd.com/read/28429626/promising-immunotherapy-against-fungal-diseases
#2
Wilfried Posch, Marion Steger, Doris Wilflingseder, Cornelia Lass-Flörl
Despite the relatively high efficacy of antifungal drugs, invasive fungal infections (IFIs) are still associated with tremendous morbidity and mortality, since late diagnosis makes an antifungal drug therapy inefficient. Therefore, antifungal immunotherapies to specifically strengthen the host´s own immune mechanisms constitute an additional promising strategy in taking action against fungal pathogens. Areas covered: The authors summarize efforts in research and clinical trials to provide safe and efficient immunotherapeutic options against invasive fungal diseases...
April 21, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28425787/defining-the-proteomic-landscape-of-rheumatoid-arthritis-progress-and-prospective-clinical-applications
#3
Lucía Lourido, Francisco J Blanco, Cristina Ruiz-Romero
The heterogeneity of Rheumatoid Arthritis (RA) and the absence of clinical tests accurate enough to identify the early stages of this disease have hampered its management. Therefore, proteomics research is increasingly focused on the discovery of novel biological markers, which would not only be able make an early diagnosis, but also to gain insight into the different pathological mechanisms underlying the heterogeneity of RA and also to stratify patients, which is critical to enabling effective treatments...
April 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28425652/endoscopic-findings-of-esophagogastric-junction-in-children
#4
Yoshiko Nakayama, Shinobu Ida
Esophagogastric landmarks are recognizable in the same way both in children and in adults, and palisade-shaped vessels can be observed at the distal position of esophageal mucosa, even in infants. Few studies have been done in respect to Barrett's esophagus (BE) in children. Incidence of endoscopically suspected BE among all children undergoing esophagogastroduodenoscopy (EGD) is approximately 0.25-1.4%, but can be up to 9.7% in patients with gastroesophageal reflux disease (GERD). Some data suggest that BE is an acquired disorder and point to the possibility of a congenital component in combination with severe mucosal injury...
April 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28423850/a-method-for-estimating-the-risk-associated-with-delaying-initial-treatment-in-breast-cancer
#5
Jonathan Lenchner, Charity Wayua
Over the past twenty-five years the time from diagnosis of breast cancer to the initiation of therapy has steadily grown. In this note we present a mechanism to give a ballpark estimate of the risk associated with delaying therapy given a specific set of presenting patient data.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28421481/cancer-as-a-risk-factor-for-cardiovascular-disease
#6
REVIEW
Dana Elena Giza, Gloria Iliescu, Saamir Hassan, Konstantinos Marmagkiolis, Cezar Iliescu
Improvements in early diagnosis and cancer treatments have contributed to high survival rates for many cancer patients. However, these patients often die of cardiovascular disease rather than recurrence of their cancer. Heart disease manifesting after cancer may be due to several mechanisms: shared cardiovascular risks between cancer and cardiovascular disease, inflammatory states associated with malignancies, and/or cardiotoxic effects of cancer therapy. Cancer treatment increases the risk of cardiovascular diseases directly by damaging critical structures of the heart or indirectly by promoting accelerated atherosclerosis...
June 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28420670/confirmed-early-myocardial-rupture-in-a-patient-with-pulseless-electrical-activity-pea-following-late-presentation-of-st-elevation-myocardial-infarction
#7
Baskar Sekar, Joe Martins, Sanjiv Petkar
A 69 year old male, an ex-smoker, was admitted with ongoing chest pain of 11 hours duration. Past medical history included treated hypertension and gastro-oesophageal reflux disease. He delayed seeking medical attention as he assumed the pain to be due to indigestion and kept taking antacids without much symptomatic relief. Clinical examination on arrival was unremarkable. Admission 12 lead electrocardiogram (ECG) was diagnostic of a recent anterolateral myocardial infarction (MI) (Figure 1a). Bedside trans-thoracic echocardiogram (TTE) confirmed an established anterolateral MI (Video 1, Figure 1b)...
April 18, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28418852/structural-homologies-between-phenformin-lipitor-and-gleevec-aim-the-same-metabolic-oncotarget-in-leukemia-and-melanoma
#8
REVIEW
Gábor Somlyai, T Que Collins, Emmanuelle J Meuillet, Patel Hitendra, Dominic P D'Agostino, László G Boros
Phenformin's recently demonstrated efficacy in melanoma and Gleevec's demonstrated anti-proliferative action in chronic myeloid leukemia may lie within these drugs' significant pharmacokinetics, pharmacodynamics and structural homologies, which are reviewed herein. Gleevec's success in turning a fatal leukemia into a manageable chronic disease has been trumpeted in medical, economic, political and social circles because it is considered the first successful targeted therapy. Investments have been immense in omics analyses and while in some cases they greatly helped the management of patients, in others targeted therapies failed to achieve clinically stable recurrence-free disease course or to substantially extend survival...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416776/clinical-value-of-mir-101-3p-and-biological-analysis-of-its-prospective-targets-in-breast-cancer-a-study-based-on-the-cancer-genome-atlas-tcga-and-bioinformatics
#9
Chun-Yao Li, Dan-Dan Xiong, Chun-Qin Huang, Rong-Quan He, Hai-Wei Liang, Deng-Hua Pan, Han-Lin Wang, Yi-Wen Wang, Hua-Wei Zhu, Gang Chen
BACKGROUND MiR-101-3p can promote apoptosis and inhibit proliferation, invasion, and metastasis in breast cancer (BC) cells. However, its mechanisms in BC are not fully understood. Therefore, a comprehensive analysis of the target genes, pathways, and networks of miR-101-3p in BC is necessary. MATERIAL AND METHODS The miR-101 profiles for 781 patients with BC from The Cancer Genome Atlas (TCGA) were analyzed. Gene expression profiling of GSE31397 with miR-101-3p transfected MCF-7 cells and scramble control cells was downloaded from Gene Expression Omnibus (GEO), and the differentially expressed genes (DEGs) were identified...
April 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28414668/autoimmune-diabetes-presented-with-diabetic-ketoacidosis-induced-by-immunotherapy-in-an-adult-with-melanoma
#10
A A Alzenaidi, J Dendy, L Rejjal
INTRODUCTION: Immunotherapy has been approved for treatment of melanoma. Autoimmune endocrinopathies have been reported in trials involving immunotherapy but autoimmune diabetes has not been definitively linked to them. Here we describe a case of autoimmune diabetes presenting with DKA after receiving combined immunotherapy with anti-CTLA4 and anti-PD1 monoclonal antibodies. CASE: A 47year old gentleman with metastatic melanoma presented to our institution with confusion, abdominal pain and decreased oral intake...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414564/tivantinib-for-the-treatment-of-hepatocellular-carcinoma
#11
Jan Best, Clemens Schotten, Gregor Lohmann, Guido Gerken, Alexander Dechêne
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with a poor prognosis due to late diagnosis in the majority of cases. Physicians are frequently confronted with patients who are not eligible for curative or locoregional treatments any more. In this scenario, the multi-tyrosine kinase inhibitor sorafenib remains the only systemic first-line treatment option providing modest survival benefit compared to placebo with significant but for most patients acceptable adverse effects...
April 17, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28413489/retrospective-review-of-epidemic-viral-pneumonia-cases-in-turkey-a-multicenter-study
#12
Mustafa Çörtük, Murat Acat, Onur Yazici, Zehra Yasar, Kemal Kiraz, Sena Yapicioglu Ataman, Elif Tanriverdi, Burcak Zitouni, Cenk Kirakli, Ozlem Ediboglu, Fevziye Tuksavul, Adem Dirican, Hale Kefeli Celik, Sevket Ozkaya, Erdogan Cetinkaya
Influenza A (H1N1) caused its first pandemic in 2009 in USA and Mexico. Since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. This is due in part to pandemic influenza A infection having greater impact on populations <65 years old than other viral strains, including seasonal influenza. Chest radiographies of those affected displayed a rapid progression of patchy infiltrates, and a large proportion of individuals required admission to intensive care units (ICU)...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28410587/overview-of-cancer-incidence-and-mortality-among-people-living-with-hiv-aids-in-british-columbia-canada-implications-for-haart-use-and-nadm-development
#13
Connie G Chiu, Danielle Smith, Kate A Salters, Wendy Zhang, Steve Kanters, David Milan, Julio S G Montaner, Andy Coldman, Robert S Hogg, Sam M Wiseman
BACKGROUND: The objective of this study is to evaluate the incidence of non-AIDS defining malignancies (NADMs) among people living with HIV/AIDS (PLWHA) in British Columbia, focusing on clinical correlates, highly active antiretroviral therapy (HAART) use, and survival, in order to elucidate mechanisms for NADM development. METHODS: A retrospective population based analysis was carried out for individuals with HIV/AIDS that began their treatment between 1996 and 2008...
April 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28410379/new-insights-into-valve-related-intramural-and-intracellular-bacterial-diversity-in-infective-endocarditis
#14
Andreas Oberbach, Nadine Schlichting, Stefan Feder, Stefanie Lehmann, Yvonne Kullnick, Tilo Buschmann, Conny Blumert, Friedemann Horn, Jochen Neuhaus, Ralph Neujahr, Erik Bagaev, Christian Hagl, Maximilian Pichlmaier, Arne Christian Rodloff, Sandra Gräber, Katharina Kirsch, Marcus Sandri, Vivek Kumbhari, Armirhossein Behzadi, Amirali Behzadi, Joao Carlos Correia, Friedrich Wilhelm Mohr, Maik Friedrich
AIMS: In infective endocarditis (IE), a severe inflammatory disease of the endocardium with an unchanged incidence and mortality rate over the past decades, only 1% of the cases have been described as polymicrobial infections based on microbiological approaches. The aim of this study was to identify potential biodiversity of bacterial species from infected native and prosthetic valves. Furthermore, we compared the ultrastructural micro-environments to detect the localization and distribution patterns of pathogens in IE...
2017: PloS One
https://www.readbyqxmd.com/read/28410142/theranostic-biomarkers-in-hypertrophic-cardiomyopathy-insights-in-a-long-road-ahead
#15
Carmem L Sartorio, Davide Lazzeroni, Gloria Bertoli, Paolo G Camici
The study of biomarkers and their related signalling pathways has allowed the development of new therapeutic strategies in a range of disorders. However, in hypertrophic cardiomyopathy (HCM), which is the most common hereditary cardiac disease, there are many potential biomarkers described, but their specificity and applicability for HCM remains an open field. The aim of the present review is to provide an overview of molecules that could give some insight into the pathophysiologic mechanisms underlying HCM, especially to those with "theranostic" - a combination of diagnostics and therapy - potential...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28409700/high-yield-of-biologically-active-recombinant-human-fibroblast-growth-factor-16-in-e-coli-and-its-mechanism-of-proliferation-in-ncl-h460-cells
#16
Jiliang Cheng, Zhaoxiang Fang, Huanhuan Yang, Yong Li, Haishan Tian, Weiyue Gong, Taotao Chen, Min Liu, Xiaokun Li, Chao Jiang
Fibroblast growth factor-16 (FGF16) is a member of FGF9 subfamily, which plays key roles in promoting mitosis and cell survival, and also involved in embryonic development, cell growth, tissue repair, morphogenesis, tumor growth and invasion. However, the successful high-yield purification of recombinant human FGF16 (rhFGF16) protein has not been reported. In addition, lung cancer is a major cause of cancer-related deaths, which threats people's lives and its incidence has continued to rise. Learning pathways or proteins, which involved in lung tumor progression will contribute to the development of early diagnosis and targeted therapy...
April 14, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28409560/identification-of-differentially-expressed-genes-and-their-upstream-regulators-in-colorectal-cancer
#17
H Y Liu, C J Zhang
To identify the differentially expressed genes (DEGs) and their transcription factors (TFs) in colorectal cancer (CRC). We performed an integrated analysis of microarray studies. Functional annotation and CRC-specific transcriptional regulatory network construction were performed. Expression of selected DEGs and TFs was verified with The Cancer Genome Atlas (TCGA) data sets and qRT-PCR. SurvMicro was used to analyze the correlation between the overall survival time of CRC patients and the expression of DEGs and TFs...
April 14, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28408630/current-and-emerging-therapies-in-multiple-sclerosis-implications-for-the-radiologist-part-1-mechanisms-efficacy-and-safety
#18
REVIEW
C McNamara, G Sugrue, B Murray, P J MacMahon
Imaging for the diagnosis and follow-up of patients with suspected or confirmed multiple sclerosis is a common scenario for many general radiologists and subspecialty neuroradiologists. The field of MS therapeutics has rapidly evolved with multiple new agents now being used in routine clinical practice. To provide an informed opinion in discussions concerning newer MS agents, radiologists must have a working understanding of the strengths and limitations of the various novel therapies. The role of imaging in MS has advanced beyond monitoring and surveillance of disease activity to include treatment complications...
April 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28408314/targeting-endothelial-metaflammation-to-counteract-diabesity-cardiovascular-risk-current-and-perspective-therapeutic-options
#19
REVIEW
Maria Assunta Potenza, Carmela Nacci, Maria Antonietta De Salvia, Luca Sgarra, Massimo Collino, Monica Montagnani
The association of obesity and diabetes, termed "diabesity", defines a combination of primarily metabolic disorders with insulin resistance as the underlying common pathophysiology. Cardiovascular disorders associated with diabesity represent the leading cause of morbidity and mortality in the Western world. This makes diabesity, with its rising impacts on both health and economics, one of the most challenging biomedical and social threats of present century. The emerging comprehension of the genes whose alteration confers inter-individual differences on risk factors for diabetes or obesity, together with the potential role of genetically determined variants on mechanisms controlling responsiveness, effectiveness and safety of anti-diabetic therapy underlines the need of additional knowledge on molecular mechanisms involved in the pathophysiology of diabesity...
April 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28407464/practical-management-of-peripartum-cardiomyopathy
#20
Mi-Jeong Kim, Mi-Seung Shin
Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy that causes systolic heart failure (HF) in previously healthy young women. Despite latest remarkable achievement, unifying pathophysiologic mechanism is not well established. Considering close temporal relationship to pregnancy, the recent prolactin theory is promising. Abnormal short form of 16-kDa prolactin may be produced in the oxidative stress milieu, show anti-angiogenic effect and damage cardiovascular structure in late pregnancy. Future study is needed to determine whether abnormal prolactin system is useful as a biomarker for diagnosis and therapy of PPCM...
April 14, 2017: Korean Journal of Internal Medicine
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